This application relates to medical devices. Specifically, but not by way of limitation, this application relates to inserting medical devices into a patient where the trajectory of the medical device is adjustable from a remote location.
The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.
When introducing a primary medical device to the inside of a patient, one type of procedure utilizes two additional devices that interact with the primary medical device to aid in precision introduction of the primary medical device. The primary medical device includes an active portion attached to a distal end that may include, but is not limited to: drug delivery capability; a tissue removal instrument such as a laser; an instrument for attaching an electrode; etc. An introducer is a secondary medical device that may be used in a surgical procedure to move a primary medical device along an introduction axis, into or out of the patient. The introducer may be attached to another secondary medical device called a trajectory guide that positions the introducer in the direction of the area to be explored in the patient.
It is important in precision surgical procedures such as neurosurgery that the exact position of the primary medical device is known in precise relation to the position of interest within the body of the patient. For this reason, the relative position of the primary medical device is carefully controlled by secondary medical devices such as introducers and trajectory guides. The trajectory guide fixes the introduction axis to be used by the introducer in three-dimensional space relative to the patient, and the introducer controls the position (depth inside the patient) of the primary medical device along the introduction axis.
To ensure that the secondary medical devices are accurately adjusted relative to the location of interest inside the patient, the trajectory guide must be fixed relative to a patient reference frame. The patient reference frame includes the actual patient, and other objects or devices relative to which the patient is fixed. The trajectory guide may therefore be fixed directly to the patient in one embodiment. Alternatively, the trajectory guide may be fixed to an intermediate object such as a stereotactic headframe or similar object attached to an operating table, with the patient being fixed to the operating table. For real time imaging, various locating devices may then be attached to the patient reference frame and to the primary medical device reference frame to determine their locations with respect to each other. If retrospective images are being used instead of real time imaging, then the secondary medical devices may be aligned with respect to reference points called fiducials that are located on the patient and that are also visible on the retrospective images.
In real time imaging, the alignment procedure frequently involves the use of a magnetic resonance imaging (MRI) station such as a long bore MR scanner. The MR scanner allows the surgeon to locate the area of interest inside the patient, and to plot a trajectory towards the area of interest. Other types of tissue imaging such as CT and PET are also available.
Although cables or hydraulics could be used to remotely control a secondary medical device, the distance of remote operation is limited. Connecting lines such as cables or hydraulic lines experience friction effects when the connecting lines become sufficiently long. Material compression/tension may also occur over long distances in the cables, housings, hydraulic fluid, etc. Forces such as friction and material compression/tension lead to less accurate adjustment of the secondary device. This effect increases as the remote distance between the patient and the surgeon increases.
Cable communication devices are typically also designed to be adjusted manually, which requires a human operator. In a situation where the surgeon viewing the MR image is several rooms away from the patient, or even miles away from the patient, a second local operator is required to adjust the secondary medical device. As discussed above, this operator must be relatively near the patient due to less accurate adjustments as the operator becomes more remote and the connecting lines become increasingly long.
Another approach that can be used in conjunction with an MR scanner uses a single unit actuator to control the primary medical device. A drawback with this device is that when used inside an MR scanner environment, the entire device must be manufactured to be MR compatible. Devices that are used inside the magnet of an MR imaging scanner cannot be manufactured using magnetic materials due to their interaction with the scanner magnet during operation. Certain non-magnetic metallic materials also interfere with the image being taken, and cannot be used. Even if used outside an MR scanner, the single unit nature of this approach requires the entire device to be sterilized between procedures, or disposed of after each use.
The present inventors have recognized a need for a trajectory guide that can be adjusted without removing the patient from an MR scanner between adjustments. What is also needed is a trajectory guide that can be operated in such a way as to eliminate the need for a second surgical operator in addition to the surgeon viewing the MR scanner image. What is also needed is a trajectory guide that minimizes the negative effects of friction and material compression associated with excessively long cable driven devices. What is also needed is a trajectory guide that is manufactured to be disposable or convenient to sterilize between procedures.
An alignment device is shown that includes a base. The base is mounted to a patient reference frame, and may be attached directly to the patient. An insertion guide is attached to the base by an adjustable joint. A local adjustment mechanism is attached to the adjustable joint such that when actuated, the orientation of the insertion guide is adjusted. An actuator is remotely coupled to the local adjustment mechanism, and the actuator can be controlled from a remote location.
In some embodiments, the actuator may be located adjacent to the adjustment devices, in other embodiments, the actuator may be located remote from the adjustment devices. The actuator may be detachable from the adjustment devices and the trajectory guide. The actuator may include electrically powered devices such as an electric motor or a stepper motor.
The alignment device may be part of an alignment system. The system may include an imaging device such as a MRI. The alignment device may be attached to a control module such as a microcomputer. The control module may obtain some of the input information from a first reference device, the reference device being mounted to a primary medical device reference frame. The first reference device may include a number of light emitting diodes (LEDs), or it may include a number of light reflecting point objects. It may also include one or more electrical coils that are influenced by the magnetic field in a MRI. It may also include a linear encoder or a potentiometer.
A second reference device may be included to establish a patient reference frame. The patient reference frame may be compared to the primary device reference frame to establish the location of the primary medical device relative to the patient.
Although specific embodiments have been illustrated and described herein, it will be appreciated by those skilled in the art that any arrangement which is calculated to achieve the same purpose may be substituted for the specific embodiment shown. This application is intended to cover any adaptations of variations of the present disclosure. It is to be understood that the provided description is intended to be illustrative, and not restrictive. The scope of the disclosure includes any other applications in which the disclosed structures and fabrication methods are used. The scope of the disclosure should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
a is a perspective view of a first trajectory guide.
b is a perspective view of one embodiment of a trajectory.
a is a schematic diagram of one embodiment of an introduction system.
b is a schematic diagram of another embodiment of an introduction system.
a is a schematic diagram of another embodiment of an introduction system.
b is a schematic diagram of another embodiment of an introduction system.
The introducer 220 shown includes a device holder 222 that moves along a range of motion on a slide 224. The position of the device holder 222 along the range of motion is controlled by a first communication line 226 and a second communication line 228. In this embodiment, the first and second communication lines 226 and 228 are each push-pull cables that may be used to operate the introducer 220 remotely.
The trajectory guide 230 shown includes an insertion guide 232. The position of the insertion guide 232 is controlled by a first interface 234 and a second interface 236. In this embodiment, the first and second interface 234 and 236 are rotating shafts that mechanically adjust an angle of the insertion guide in three dimensional space. The trajectory guides will be discussed in more detail below.
Although the introduction system described could be used to introduce a primary medical device into several areas of a patient, the example discussed involves neurosurgery. The primary medical device in this example is a catheter that is used to probe an internal area of the human brain. The trajectory guide 230 is attached to a patient reference frame. The patient reference frame may include a stereotactic headframe that the trajectory guide is secured to. In this embodiment, the trajectory guide 230 is secured directly to the skull using a number of screws. The introducer 220 is then secured to a proximal end of the insertion guide 232. The primary medical device 210 is inserted through the device holder 222, through the insertion guide 232 and into an opening in the skull. The angle of the insertion guide, relative to the patient reference frame determines an insertion axis. The orientation of this insertion axis is controlled by the trajectory guide, and the position of the active portion 216 of the primary medical device along the insertion axis is controlled by the introducer 220.
a and 3b show a first embodiment of the trajectory guide. The trajectory guide 230 includes an insertion guide 32 attached to a base 380 by a ball and socket joint 382. The insertion guide has an insertion axis 33 along which the primary medical device is guided. Orientation of the insertion guide, and hence the insertion axis, is accomplished with a pair of adjustment devices. It should be noted that although in this embodiment, a ball and socket joint is used with a pair of adjustment devices, that any of a number of joints could be used and any number of adjustment devices could be used without departing from the scope of the disclosure. Additionally, while this embodiment describes rotational adjustments in angle of the insertion axis, other embodiments include adjustments such as translational motion of the insertion axis within three dimensional space.
A first adjustment device includes a first slide 310. The first slide 310 includes a block 312 that rides along a pair of rails 314. The block is attached to a first threaded member 316. When the first threaded member 316 is actuated, the block 312 is moved along the rails 314 in a first degree of freedom shown by arrows 317. Block 312, includes a collar 318 that encompasses the insertion guide 32. The collar 318 is designed as a ball and socket joint with the block 312 so that various angles of the insertion guide 32 can be accommodated.
A second adjustment device includes a second slide 350. The second slide 350 includes a pair of rails 352 upon which the entire first slide 310 moves. The first slide 310 has a second threaded member 354 attached to it, such that when rotated, the first slide 310 moves along the rails 352 in a second degree of freedom shown by arrows 355. The collar 318 of the first slide 310 also serves to accommodate angles of adjustment made with the second slide 350.
Further attached to the first threaded member 316 is a first beveled gear 320 that meshes with a second bevel gear 322. The second bevel gear 322 is attached to a shaft 324 that in turn is attached to the first interface 234. The second interface 236 is connected to the second threaded member 354.
In operation, rotation of the first interface 234 drives the shaft 324 and rotates the second bevel gear 322. The second bevel gear 322 engages the first bevel gear 320 causing the first threaded member 316 to thread through the first bevel gear 320. Motion of the first threaded member 316 through the first bevel gear 320 in turn moves the block 312 and changes the angle of the insertion axis 33 in the direction of arrows 317. Rotation of the second interface 236 directly drives the second threaded member 354 which moves the first slide 310. Rotation of the second interface 236 therefore adjusts the angle of the insertion axis 33 in the direction of arrows 355. By adjusting a combination of the first and second slides 310 and 350, any of a number of orientations of the insertion axis 33 can be obtained in three dimensional space.
Because of the local positioning of adjustment, devices such as the first and second slide 310 and 350, precise adjustments to the angle of the insertion axis 33 can be made with negligible effects from friction, material compression/tension, or hysteresis. In contrast, adjustment devices that are remotely coupled to the insertion guide are subject to less alignment accuracy due to friction in cables, stretching of cables, or hysteresis of the cable once it has been stretched for example.
A second embodiment of a trajectory guide is shown in
A worm drive 450 is also shown in
In operation, rotation of the first interface 430 drives rotation of the second gear 428 which in turn engages the first gear 426. The first gear is fixed spatially, but is free to rotate. In rotation, the first gear 426 threads the threaded member 420 back and forth in the directions according to arrows 422. In turn, this adjusts the orientation of the insertion guide 412 in the range of motion indicated by arrows 422. Rotation of the second interface 456 drives rotation of the worm gear 452, which in turn engages the drive gear 451. Because the drive gear 451 is attached to the slide 414, which is attached to the insertion guide 412, rotation of the drive gear 451 adjusts the orientation of the insertion guide 412 according to arrows 454. By adjusting a combination of the slide 414 and the worm drive 450, any of a number of orientations of the insertion guide 412 can be obtained in three dimensional space.
Similar to the first embodiment of the trajectory guide, the local positioning of adjustment devices, such as the slide 414 and the worm drive 450, allows precise adjustments to the angle of the insertion guide 412 that can be made with negligible effects from friction, material compression/tension, or hysteresis.
Although specific mechanical adjustment devices have been shown in these embodiments, one skilled in the art will recognize that other adjustment devices can be used as locally mounted adjustment devices without departing from the scope of the invention.
a and 6b show configurations of an introduction system according to the invention. Two separate rooms are shown, a control room 600 from where a tissue imaging device such as an MRI is controlled, and an operating room 650 where a patient is located and where the active tissue imaging device such as an MRI magnet (scanner) is located. Other types of tissue imaging such as CT and PET are also possible. The MRI control system 614 is shown coupled to a first data transmitter/receiver 610. A control module such as a microcomputer 616 is also located in the control room 600. The control module 616 in one embodiment is integrated within the control system 614. The devices in the rooms shown in
In
In operation, the surgeon is located in the control room 600, and is viewing the scanned image of the patient in the operating room 650. The surgeon is also able to access the actuator control circuit 616. In real time, the surgeon is able to remotely view the patient, and remotely make adjustments to the insertion axis of the trajectory guide. A signal for an adjustment is sent from the first data transmitter/receiver 610 to the second data transmitter/receiver 652. The received signal is sent to the actuator 654 that in turn actuates the adjustment device 658.
The actuator 654 in this embodiment might include a electrical motor or another electrical actuator. The actuator 654 provides the force necessary to actuate the adjustment device, which as shown in this embodiment, mainly translates the force provided by the actuator into the desired motion of the insertion guide. An advantage of this configuration is that because the actuator is not located within the MRI scanner, it does not need to be manufactured to be MR compatible. Actuators such as electric motors are difficult and expensive to design is such a way as to be MR compatible. Additionally, the trajectory guide, with its associated adjustment device 658 can be designed to be easily detachable. In this way, the more expensive actuator 654 can be reused, potentially without intensive sterilization, and the trajectory device can be more easily sterilized, or alternatively, disposed of after each procedure.
b shows a similar arrangement to
The configurations shown in
a and 7b show the use of the introduction system without the aid of real time tissue imaging. Using previously obtained images, the trajectory guide can be registered with fiducials located on the patient, the fiducials also being visible in the previously obtained images.
The operating room 700 in
Alternatively in
Both user inputs 900 and electronic inputs 910 are used as data inputs 920 to calculate the insertion axis 830 and the line TB from
In one embodiment described above, the configuration is a closed loop system. In the closed loop system, once a target location has been input into the control module, the control circuit calculates and adjusts the trajectory without further input from the user. The closed loop system is constantly evaluating the condition of the system through a feedback loop. Feedback inputs include the orientation/position of the primary and secondary medical devices and, in real time imaging, the target location. A closed loop system as such, eliminates the need for several manual operator iterative adjustments to the trajectory guide or other secondary devices. A closed loop system is also capable of compensating for any remaining frictional or compression/tension loss effects in the system. One closed loop configuration makes the necessary adjustments to align the trajectory guide all at one speed. Another closed loop configuration adjusts the speed of the adjustments by slowing down the adjustment speed as the exact alignment/position is near. Another configuration calculates the moves necessary for alignment, and actuates the adjustment devices incrementally, waiting for operator input between moves.
Although the closed loop system described focuses on alignment of a trajectory guide, other secondary medical devices may be controlled using the closed loop system, such as an introducer. In this manner, all orientations and positions of a primary medical device in a procedure are controlled through the control module.
One skilled in the art will recognize that although a microcomputer is described, any of a number of varieties of control modules could be used. Additionally, the software or algorithm used could be configured in many different embodiments to achieve the same goal of aligning the insertion axis 830 with the line TB.
Electronic inputs 910 from
Another embodiment includes a first reference device located on the reference frame of the primary medical device. The reference device includes a number of light emitting diodes (LEDs) that are detectable with the imaging device. If three LEDs are used, the three points would determine the orientation of the primary medical device in three dimensions. Alternatively, the three points could be light reflecting points, where a light source is directed towards the light reflecting points and the reflected light is detected to determine an orientation of the primary medical device in three dimensional space.
Another example attaches one or more electrical coils to the primary medical device reference frame. In an MRI environment, an electrical coil has a varying electrical response depending on its orientation inside the MR scanner. The variations in electrical response can be used to indicate an orientation and/or location of the primary medical device in three dimensional space.
Another example attaches an encoder or a potentiometer to the primary medical device reference frame. The use of an encoder or potentiometer locates the primary medical device along an axis, the orientation of which may have been determined by the number of LEDs, reflecting points, or electrical coils described above.
Additionally, a second reference device could be located in the patient reference frame. If two reference devices are used (one attached to the primary medical device reference frame, the other attached to the patient reference frame) then the first and second reference devices can be used to determine a location of the primary medical device relative to the patient.
Although specific embodiments have been illustrated and described herein, it will be appreciated by those skilled in the art that any arrangement which is calculated to achieve the same purpose may be substituted for the specific embodiment shown. This application is intended to cover any adaptations of variations of the present invention. It is to be understood that the above description is intended to be illustrative, and not restrictive. The scope of the invention includes any other applications in which the above structures and fabrication methods are used. The scope of the invention should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
This application is a divisional of U.S. patent application Ser. No. 09/825,786 filed on Apr. 4, 2001, now U.S. Pat. No. 7,366,561, issued on Apr. 29, 2008, which claims the benefit of U.S. Provisional Application No. 60/195,662, filed on Apr. 7, 2000. The disclosures of the above applications are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
1129333 | Clarke | Feb 1915 | A |
1664210 | Hall | Mar 1928 | A |
2119649 | Roosen | Jun 1938 | A |
2135160 | Beekhuis | Nov 1938 | A |
2697433 | Zehnder | Dec 1954 | A |
3055370 | McKinney et al. | Sep 1962 | A |
3135263 | Connelley, Jr. | Jun 1964 | A |
3223087 | Vladyka et al. | Dec 1965 | A |
3273559 | Evans | Sep 1966 | A |
3282152 | Myer | Nov 1966 | A |
3402710 | Paleschuck | Sep 1968 | A |
3444861 | Schulte | May 1969 | A |
3508552 | Hainault | Apr 1970 | A |
3672352 | Summers | Jun 1972 | A |
3760811 | Andrew et al. | Sep 1973 | A |
3893449 | Lee et al. | Jul 1975 | A |
4040427 | Winnie | Aug 1977 | A |
4230117 | Anichkov et al. | Oct 1980 | A |
4341220 | Perry | Jul 1982 | A |
4345606 | Littleford | Aug 1982 | A |
4355645 | Mitani et al. | Oct 1982 | A |
4386602 | Sheldon et al. | Jun 1983 | A |
4448195 | LeVeen et al. | May 1984 | A |
4463758 | Patil et al. | Aug 1984 | A |
4475550 | Bremer et al. | Oct 1984 | A |
4483344 | Atkov et al. | Nov 1984 | A |
4571750 | Barry | Feb 1986 | A |
4572198 | Codrington | Feb 1986 | A |
4579120 | MacGregor | Apr 1986 | A |
4598708 | Beranek | Jul 1986 | A |
4608977 | Brown | Sep 1986 | A |
4617925 | Laitinen et al. | Oct 1986 | A |
4618978 | Cosman | Oct 1986 | A |
4629451 | Winters et al. | Dec 1986 | A |
4638798 | Shelden et al. | Jan 1987 | A |
4660563 | Lees | Apr 1987 | A |
4665928 | Linial et al. | May 1987 | A |
4699616 | Nowak et al. | Oct 1987 | A |
4706665 | Gouda | Nov 1987 | A |
4733661 | Palestrant | Mar 1988 | A |
4755642 | Parks | Jul 1988 | A |
4791934 | Brunnett | Dec 1988 | A |
4793355 | Crum et al. | Dec 1988 | A |
4807620 | Strul et al. | Feb 1989 | A |
4809694 | Ferrara | Mar 1989 | A |
4824436 | Wolinsky | Apr 1989 | A |
4826487 | Winter | May 1989 | A |
4869247 | Howard, III et al. | Sep 1989 | A |
4883053 | Simon | Nov 1989 | A |
4896673 | Rose et al. | Jan 1990 | A |
4902129 | Siegmund et al. | Feb 1990 | A |
4922924 | Gambale et al. | May 1990 | A |
4955891 | Carol | Sep 1990 | A |
4957481 | Gatenby | Sep 1990 | A |
4986280 | Marcus et al. | Jan 1991 | A |
4986281 | Preves et al. | Jan 1991 | A |
4989608 | Ratner | Feb 1991 | A |
4991579 | Allen | Feb 1991 | A |
5006122 | Wyatt et al. | Apr 1991 | A |
5024236 | Shapiro | Jun 1991 | A |
5027818 | Bova et al. | Jul 1991 | A |
5050608 | Watanabe et al. | Sep 1991 | A |
5052329 | Bennett | Oct 1991 | A |
5057106 | Kasevich et al. | Oct 1991 | A |
5065761 | Pell | Nov 1991 | A |
5078140 | Kwoh | Jan 1992 | A |
5078142 | Siczek et al. | Jan 1992 | A |
5080662 | Paul | Jan 1992 | A |
5087256 | Taylor et al. | Feb 1992 | A |
5099846 | Hardy | Mar 1992 | A |
5102402 | Dror et al. | Apr 1992 | A |
5116345 | Jewell et al. | May 1992 | A |
5120322 | Davis et al. | Jun 1992 | A |
5125888 | Howard et al. | Jun 1992 | A |
5142930 | Allen et al. | Sep 1992 | A |
5143086 | Duret et al. | Sep 1992 | A |
5154179 | Ratner | Oct 1992 | A |
5154723 | Kubota et al. | Oct 1992 | A |
5163430 | Carol | Nov 1992 | A |
5166875 | Machida et al. | Nov 1992 | A |
5171217 | March et al. | Dec 1992 | A |
5174297 | Daikuzono et al. | Dec 1992 | A |
5186174 | Schlondorff et al. | Feb 1993 | A |
5201742 | Hasson | Apr 1993 | A |
5207223 | Adler | May 1993 | A |
5207688 | Carol | May 1993 | A |
5211165 | Dumoulin et al. | May 1993 | A |
5222499 | Allen et al. | Jun 1993 | A |
5230338 | Allen et al. | Jul 1993 | A |
5230623 | Guthrie et al. | Jul 1993 | A |
5246448 | Chang | Sep 1993 | A |
5257998 | Ota et al. | Nov 1993 | A |
5263956 | Nobles | Nov 1993 | A |
5269305 | Corol | Dec 1993 | A |
5279309 | Taylor et al. | Jan 1994 | A |
5279575 | Sugarbaker | Jan 1994 | A |
5290266 | Rohling et al. | Mar 1994 | A |
5291890 | Cline et al. | Mar 1994 | A |
5300080 | Clayman et al. | Apr 1994 | A |
5305203 | Raab et al. | Apr 1994 | A |
5309913 | Kormos et al. | May 1994 | A |
5330485 | Clayman et al. | Jul 1994 | A |
5361763 | Kao et al. | Nov 1994 | A |
5366446 | Tal et al. | Nov 1994 | A |
5375596 | Twiss et al. | Dec 1994 | A |
5380302 | Orth | Jan 1995 | A |
5383454 | Bucholz | Jan 1995 | A |
5387220 | Pisharodi | Feb 1995 | A |
5397323 | Taylor et al. | Mar 1995 | A |
5445166 | Taylor | Aug 1995 | A |
5452720 | Smith et al. | Sep 1995 | A |
5464446 | Dreessen et al. | Nov 1995 | A |
5470307 | Lindall | Nov 1995 | A |
5474564 | Clayman et al. | Dec 1995 | A |
5483961 | Kelly et al. | Jan 1996 | A |
5494655 | Rocklage et al. | Feb 1996 | A |
5515160 | Schulz et al. | May 1996 | A |
5517990 | Kalfas et al. | May 1996 | A |
5528652 | Smith et al. | Jun 1996 | A |
5572999 | Funda et al. | Nov 1996 | A |
5575798 | Koutrouvelis | Nov 1996 | A |
5618288 | Calvo et al. | Apr 1997 | A |
5622170 | Schulz | Apr 1997 | A |
5638819 | Manwaring et al. | Jun 1997 | A |
5647361 | Damadian | Jul 1997 | A |
5658272 | Hasson | Aug 1997 | A |
5667514 | Heller | Sep 1997 | A |
5695501 | Carol et al. | Dec 1997 | A |
5713858 | Heruth et al. | Feb 1998 | A |
5776064 | Kalfas et al. | Jul 1998 | A |
5810712 | Dunn | Sep 1998 | A |
5833627 | Shmulewitz et al. | Nov 1998 | A |
5843150 | Dreessen et al. | Dec 1998 | A |
5851183 | Bucholz | Dec 1998 | A |
5865842 | Knuth et al. | Feb 1999 | A |
5871445 | Bucholz | Feb 1999 | A |
5873822 | Ferre et al. | Feb 1999 | A |
5891034 | Bucholz | Apr 1999 | A |
5891157 | Day et al. | Apr 1999 | A |
5927277 | Baudino et al. | Jul 1999 | A |
5954687 | Baudino | Sep 1999 | A |
5957934 | Rapoport et al. | Sep 1999 | A |
5980535 | Barnett et al. | Nov 1999 | A |
5984930 | Maciunas et al. | Nov 1999 | A |
5993463 | Truwit | Nov 1999 | A |
6044304 | Baudino | Mar 2000 | A |
6058323 | Lemelson | May 2000 | A |
6071288 | Carol et al. | Jun 2000 | A |
6076008 | Bucholz | Jun 2000 | A |
6110182 | Mowlai-Ashtiani | Aug 2000 | A |
6117143 | Hynes et al. | Sep 2000 | A |
6120465 | Guthrie et al. | Sep 2000 | A |
6206890 | Truwit | Mar 2001 | B1 |
6236875 | Bucholz et al. | May 2001 | B1 |
6254532 | Paolitto et al. | Jul 2001 | B1 |
6261300 | Carol et al. | Jul 2001 | B1 |
6282437 | Franck et al. | Aug 2001 | B1 |
6290644 | Green, II et al. | Sep 2001 | B1 |
6298262 | Franck et al. | Oct 2001 | B1 |
6529765 | Franck et al. | Mar 2003 | B1 |
6546279 | Bova et al. | Apr 2003 | B1 |
7204840 | Skakoon et al. | Apr 2007 | B2 |
Number | Date | Country |
---|---|---|
19726141 | Jan 1999 | DE |
29612100 | Aug 1999 | DE |
19820808 | Sep 1999 | DE |
19826078 | Nov 1999 | DE |
0427358 | May 1991 | EP |
0724865 | May 1991 | EP |
0609085 | Aug 1994 | EP |
0904741 | Mar 1999 | EP |
WO-8809151 | Dec 1988 | WO |
WO-9721380 | Dec 1988 | WO |
WO-9703609 | Feb 1997 | WO |
WO-9742870 | Nov 1997 | WO |
WO-9817191 | Apr 1998 | WO |
WO-9825535 | Jun 1998 | WO |
WO-0001316 | Jan 2000 | WO |
WO-0149197 | Jul 2001 | WO |
Number | Date | Country | |
---|---|---|---|
20080039869 A1 | Feb 2008 | US |
Number | Date | Country | |
---|---|---|---|
60195662 | Apr 2000 | US |
Number | Date | Country | |
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Parent | 09825786 | Apr 2001 | US |
Child | 11873154 | US |