Yaish et al., "Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors", Science, vol. 242(4880), pp. 933-935, Nov. 1988. |
Ohmichi et al., "The Tyrosine Kinase Inhibitor Tyrphostin Blocks the Cellr Actions of Nerve Growth Factor", Biochemistry, vol. 32(17), pp. 4650-4658, Apr. 1993. |
Mazumder et al., Biochemistry (1995) 34(46), 15111-15122, 1995. |
Posner et al., Molecular Pharmacology (1994), 45(4), 673-83, 1994. |
Gazit, Aviv et al., "Tyrphostins. 2. Heterocyclic and .alpha.-Substituted Benzylidenemalononitrile Tyrphostins as Potent Inhibitors of EGF Receptor and ErbB2/neu Tyrosine Kinases", Journ. Med. Chem., 34:1896-1907 (1991). |
Gazit, Aviv et al., "Tyrphostins. 3. Structure-Activity relationship Studies of .alpha.-Substituted Benzylidenemalononitrile 5-S-Aryltyrphostins", J. Med. Chem., 36:3556-3564 (1993). |
Kokosi, Jozsef et al., "Process for producing imidazo[5,1-b]quinazolin-9-one derivatives and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising such as active ingredient", Chemical Abstracts, vol. 117, abstract No. 212519, (1990). |
Merlin, Jean Claude et al., "Resonance Raman study of phenylhydrazonopropanedinitriles", Can. J. Chem., 63:1840-1844 (1985). |
Miyoshi, Hideto et al., "Quantitative analyses of the uncoupling activity of substituted phenols with mitochondria from flight muscles of house flies", Biochimica et Biophysica Acta, 935:312-321 (1988). |
Ohmichi, Masahide et al., "The Tyrokinase Kinase Inhibitor Tyrphostin Blocks the Cellular Actions of Nerve Growth Factor", Biochemistry, 32:4650-4658 (1993). |
Stout, David M. et al., "Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 1. Heteroarylamine Derivatives", J. Med. Chem., 26:808-813 (1983). |
Vogel, M. et al., "Synthese von-4-substituierten 1,2,3-Triazolo[1,5-a]-chinoxalinen.sup.2)", Journal f. prakt. Chemie: Band 329, Heft 1:101-107 (1987). |
Anafi, M. et al., 1992, "Selective Interactions of Transforming and Normal abl Proteins with ATP, Tyrosine-Coploymer Substrates, and Tyrphostins", J. Biol. Chem. 267(7):4518-4523. |
Arvidsson, A. et al., 1994, "Tyr-716 in the Platelet-Derived Growth Factor .beta.-Receptor Kinase Insert Is Involved in GRB2 Binding and Ras Activation", Molec. and Cell. Biol. 14(10):6715-6726. |
Bolen, J.B., 1993, "Nonreceptor tyrosine protein kinases", Oncogene 8:2025-2031. |
Breier, G. et al., 1992, "Expression of vascular endothelial growth factor during embryonic angiogenesis and andothelial cell differentiation", Development 114:521-532. |
Brunton, V.G. et al., 1994, "Alterations in EGF-dependent proliferative and phosphorylation events in squamous cell carcinoma cell lines by a tyrosine kinase inhibitor", Anti-Cancer Drug Design 9:311-329. |
De Vries C. et al., 1992, "The fms-Like Tyrosine Kinase, a Recpetor for Vascular Endothelial Growth Factor", Reports 21:989-991. |
Fantil, W.J. et al., 1992, "Distinct Phosphotyrosines on a Growth Factor Receptor Bind to Specific Molecules That Mediate Different Signaling Pathways", Cell 69:413-423. |
Folkman, M.J., "Antiangiogenesis", Lippincott, Alternative Strategies for Biol. Therapy, pp. 743-753, 1991. |
Houck, K.A. et al., 1992, "Dual Regulation of Vascular Endothelial Growth Factor Bioavailability by Genetic and Proteolytic Mechanisms", J. Biol. Chem. 267(36):26031-26037. |
Hu, P. et al., 1992, "Interaction of Phosphatidylinositol 3-Kinase-Associated p85 with Epidermal Growth Factor and Platelet-Derived Growth Factor Receptors", Molec. and Cell. Biol. 12(3):981-990. |
Jellinek, D. et al., 1994, "Inhibition of Receptor Binding by High-Affinity RNA Ligands to Vascular Endothelial Growth Factor", Biochemistry 33:10450-10456. |
Kashishian, A. & Cooper, J.A., 1993, "Phosphorylation Sites at the C-terminus of the Platelet-Derived Growth Factor Receptor Bind Phospholipase C.tau.1", Molec. Biol. 4:49-57. |
Kashishian, A. et al., 1992, "Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and Pl3 kinase in vivo", EMBO J. 11(4):1373-1382. |
Kaur, G. et al., 1994, "Tyrphostin induced growth inhibition: correlation with effect on p210.sup.bcr-abl autokinase activity in K562 chronic myelogenous leukemia", Anti-Cancer Drugs 5:213-222. |
Kendall, R.L., 1993, "Inhibition of vascular endothelial cell grwoth factor activity by an endogenously encoded soluble receptor", PNAS USA 90:10705-10709. |
Kim, K.J. et al., 1993, "Inhibition of vascular endothelial grwoth factor-induced angiogenesis suppresses tumor growth in vivo", Nature 362(29):841-844. |
Kinsella, J.L. et al., 1992, "Protein Kinase C Regulates Endothelial Cell Tube Formation on Basement Membrane Matrix, Matrigel", Exper. Cell Res. 199:56-62. |
Klagsbrun, M. & Soker, S., 1993, "VEGF/VPF: the angiogenesis factor found?", Current Biol. 3(10):699-702. |
Koch, A.C. et al., 1991, "SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins", Science 252:668-674. |
Kondo, S. et al., 1993, "Significance of Vascular Endothelial Grwoth Factor/Vascular Permeability Factor for Solid Tumor Growth, and its Inhibition by the Antibody", Biochem. Biophys. Res. Comm. 194(3):1234-1241. |
Liotta, L. et al., 1991, "Cancer Metastasis and Angiogenesis: An Imbalance of Positive and Negative Regulation", Cell 64:327-336. |
Maglione, D. et al., 1991, "Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor", PNAS USA 88:9267-9271. |
Maglione, D. et al., 1993, "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PIGF), are transcribed from a single gene of chromosome 14", Oncogene 8:925-931. |
Mariani, M. et al., 1994, "Inhibition of Angiogenesis by FCE 26806, A Potent Tyronase Kinase Inhibitor", Proc. of the Am. Assoc. for Cancer Res. 35:381 #2268. |
Matthews, W. et al., 1991, "A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit", PNAS USA 88:9026-9030. |
Millauer, B. et al., 1993, "High Affinity VEGF Binding and Developmental Expression Suggest Flk-1 as a Major Regulator of Vasculogenesis and Angiogenesis", Cell 72:835-846. |
Millauer, B. et al., 1994, "Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant", Nature 367:576-579. |
Nishimura, R. et al., 1993, "Two Signaling Molecules Share a Phosphotyrosine-Containing Binding Site in the Platelet-Derived Growth Factor Receptor", Molec. Cell Biol. 13(11):6889-6896. |
Oelrichs, R.B. et al., 1993, "NYK/FLK-1: A putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo", Oncogene 8:11-18. |
Plate, K.H. et al., 1993, "Up-Regulation of Vascular Endothelial Growth Factor and its Cognate Receptors in a Rat Glioma Model of Tumor Angiogenesis", Cancer Res. 53:5822-5827. |
Plowman, G.D. et al., 1994, "Receptor Tyrosine Kinases as Targets for Drug Intervention", DN&P 7(6):334-339. |
Quinn, T.P. et al., 1993, "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium", PNAS USA 90:7533-7537. |
Rozakis-Adcock, M. et al., 1992, "Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases", Nature 360:689-692. |
Sarzani, R. et al., 1992, "A Novel Endothelial Tyrosine Kinase cDNA Homologous to Platelet-Derived Growth Factor Receptor cDNA", Biochem. Biophys. Res. Comm. 186(2):706-714. |
Schlessinger, J. et al., 1992, "Growth Factor Signaling by Receptor Tyrosine Kinases", Neuron 9:383-391. |
Schucter, L.M. et al., 1991, "Succesful Treatment of Murine Melanoma with Bryostatin 1", Cancer Res. 51:682-687. |
Sherwood, L.M. et al., 1971, "Tumor Angiogenesis: Therapeutic Implications", New Engl. J. Med. 285(21):1182-1186. |
Shibuya, M. et al., 1990, "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family", Oncogene 5:519-524. |
Songyang, Z. et al., 1994, "Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav", Molec. Cell. Biol. 14(4):2777-2785. |
Songyang, Z. et al., 1993, "SH2 Domains Recognizes Specific Phosphopeptide Sequences", Cell 72:767-778. |
Takano, S. et al., 1993, "Inhibition of Angiogenesis by a Novel Diaminoanthraquinone that Inhibits Protein Kinase C.", Mol. Biol. of the Cell 4:385A (abstract). |
Terman, B.I. et al., 1992, "Identification of the KDR Tyrosine Kinase as a Receptor for Vascular Endothelial Cell Growth Factor", Biochem. Biophys. Res. Comm. 187(3):1579-1586. |
Twamley-Stein, G.M. et al., 1993, "The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells", PNAS USA 90:7696-7700. |
Ullrich, A. & Schlessinger, J., 1990, "Signal Transduction by Receptors with Tyrosine Kinase Activity", Cell 61:203-212. |
Vaisman, N. et al., 1990, "Characterization of the Receptors for Vascular Endothelial Growth Factor", J. Biol. Chem. 265:19461-19566. |
Weidner, N. et al., 1991, "Tumor Angiogenesis and Metastasis--Correlation in Invasive Breast Carcinoma", New Engl. J. Med. 324(1):1-7. |
Wright, P.S. et al., 1992, "Inhibition of Angiogenesis In Vitro and In Ovo With an Inhibitor of Cellular Protein Kinases, MDL 27032", J. Cell. Physiol. 152:448-457. |
Yamaguchi, T.P. et al., 1993, "flk-1, an flt-related receptor tyrosine is an early marker for endothelial cell precursors", Development 118:489-498. |