The present invention relates to a technical idea for manufacturing a transient sensor. More particularly, the present invention relates to a transient sensor using a two-dimensional material such as molybdenum disulfide (MoS2), wherein the transient sensor is dissolved in a biological fluid such as blood, and a method of manufacturing the transient sensor.
Recently, biological signal monitoring using biosensors has been actively studied worldwide.
Currently, the biosensor industry has a large market of about $5 billion globally. Among biosensors, biochips have high potential for development and can be applied to various fields, so the biochip industry is attracting attention as a future-oriented industry.
In addition, the market scale of biosensors is increasing by 10 to 15% every year. Therefore, economic value created by biosensor research can be very large.
Recently, development of a water-soluble silicon-based transient sensor and application thereof are expected.
The silicon-based transient sensor is manufactured to have a thin thickness and is attached to human body organs to measure biological signals. However, since the silicon-based transient sensor does not dissolve in the body, the sensor must be extracted after use.
To use biosensors in organs such as the heart and brain which are difficult to re-operate, new techniques are needed to overcome the above-described problems.
Unlike conventional materials such as silicon, when a two-dimensional material is used to manufacture a biosensor, the characteristics of the biosensor as a device can be obtained even when a single layer of the two-dimensional material is used. Therefore, two-dimensional materials can be used for manufacturing various sensors, e.g., ultra-thin film sensors.
Therefore, methods such as use of a two-dimensional material are required to solve the problems of a thin sensor manufactured according to conventional technology.
Therefore, the present invention has been made in view of the above problems, and it is one object of the present invention to provide a transient sensor using molybdenum disulfide.
It is another object of the present invention to provide a transient sensor using a water-soluble electronic element insertable into the body, wherein the transient sensor is spontaneously dissolved after serving as a sensor.
According to the present invention, since the transient sensor using the electronic element is spontaneously dissolved in vivo, a process of re-incising the site where the transient sensor is inserted may be omitted, thereby reducing inconvenience of procedures and improving convenience of a subject.
In addition, procedural costs may be reduced by reducing procedural inconvenience.
It is another object of the present invention to provide a transient sensor that has excellent chemical stability and that can be manufactured to have a very thin thickness. According to the present invention, due to the chemical stability of the transient sensor, the transient sensor may not be easily transformed into other substances, and thus in vivo stability thereof may also be excellent. In addition, due to the thin thickness of the transient sensor, the dissolving time of the transient sensor in vivo may be remarkably reduced.
It is yet another object of the present invention to provide a method of manufacturing a transient sensor. According to the present invention, the method may improve economic efficiency in lab-on-a-chip and wearable electronic device fields and may contribute to leading research on bio-nanomaterials.
In accordance with one aspect of the present invention, provided is a transient sensor using molybdenum disulfide including a water-soluble substrate; a water-soluble insulating layer deposited on the water-soluble substrate; an electrode layer formed of any one of molybdenum (Mo) and magnesium (Mg) and formed on the water-soluble insulating layer; and a channel layer including molybdenum disulfide in particle form formed on the water-soluble insulating layer to be connected to the electrode layer, wherein, when the transient sensor is inserted into living matter, the transient sensor is dissolved within a critical time in the living matter.
According to one embodiment of the present invention, the channel layer may be deposited as a single layer on the water-soluble insulating layer using metal-organic chemical vapor deposition (MOCVD) or may be deposited by performing electron beam deposition on the electrode layer. A channel may be deposited in a square wave form in the channel layer. The channel may be connected to the electrode layer.
According to one embodiment of the present invention, the channel layer may measure at least one of bioabsorbability, pressure, temperature, strain, and acceleration of the living matter.
According to one embodiment of the present invention, the critical time may be determined based on the particle size of the channel layer deposited using metal-organic chemical vapor deposition (MOCVD).
According to one embodiment of the present invention, the water-soluble substrate may be formed of any one of poly(lactic-co-glycolic acid) (PLGA) and polyvinyl alcohol (PVA).
According to one embodiment of the present invention, the water-soluble insulating layer may be formed of any one of an oxide layer and a water-soluble polymer complex by depositing any one of silicon oxide (SiO2), silicon nitride (Si3N4), hafnium oxide (HfO2), and magnesium oxide (MgO) and may be deposited on the water-soluble substrate using atmospheric pressure chemical vapor deposition (APCVD).
According to one embodiment of the present invention, at least one of the water-soluble substrate, the water-soluble insulating layer, the electrode layer, and the channel layer may be dissolved in bodily fluid contained in living matter.
According to one embodiment of the present invention, the channel layer may have a polycrystalline structure and may be deposited as a single-layer film on the water-soluble insulating layer.
According to one embodiment of the present invention, the biocompatibility of the channel layer may be determined based on the ratio of immune cells present in peripheral blood contained in the living matter into which the transient sensor is inserted and weight change of the living matter into which the transient sensor is inserted.
In accordance with another aspect of the present invention, provided is a method of manufacturing a transient sensor using molybdenum disulfide, the method including a step of depositing a water-soluble insulating layer on a water-soluble substrate; a step of forming an electrode layer using any one of molybdenum (Mo) and magnesium (Mg) on the water-soluble insulating layer; and a step of forming a channel layer including molybdenum disulfide in particle form on the water-soluble insulating layer to be connected to the electrode layer, wherein the transient sensor includes the water-soluble substrate, the water-soluble insulating layer, the electrode layer, and the channel layer, and, when the transient sensor is inserted into living matter, the transient sensor is dissolved within a critical time in the living matter.
According to one embodiment of the present invention, the step of forming a channel layer may include a step of determining the critical time by controlling the particle size of the channel layer deposited using metal-organic chemical vapor deposition (MOCVD).
According to one embodiment of the present invention, the method of manufacturing a transient sensor using molybdenum disulfide may further include a step of measuring at least one of bioabsorbability, pressure, temperature, strain, and acceleration of the living matter through the channel layer.
According to one embodiment of the present invention, the method of manufacturing a transient sensor using molybdenum disulfide may further include a step of determining the biocompatibility of the channel layer based on the ratio of immune cells present in peripheral blood contained in the living matter into which the transient sensor is inserted and weight change of the living matter into which the transient sensor is inserted.
According to the present invention, a transient sensor using molybdenum disulfide can be manufactured.
In addition, according to the present invention, a transient sensor that includes a water-soluble electronic element insertable into the body and that is spontaneously dissolved after serving as a sensor can be manufactured.
According to the present invention, since the transient sensor using the electronic element is spontaneously dissolved in vivo, a process of re-incising the site where the transient sensor is inserted can be omitted, thereby reducing inconvenience of procedures and improving convenience of a subject.
In addition, procedural costs can be reduced by reducing procedural inconvenience.
In addition, according to the present invention, a transient sensor that has excellent chemical stability and that can be manufactured to have a very thin thickness can be manufactured. According to the present invention, due to the chemical stability of the transient sensor, the transient sensor cannot be easily transformed into other substances, and thus in vivo stability thereof can also be excellent. In addition, due to the thin thickness of the transient sensor, the dissolving time of the transient sensor in vivo can be remarkably reduced
In addition, the present invention can provide a method of manufacturing a transient sensor. According to the present invention, the method can improve economic efficiency in lab-on-a-chip and wearable electronic device fields and can contribute to leading research on bio-nanomaterials.
Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings.
It should be understood that the embodiments and terminology used herein are not intended to limit the techniques described herein to specific embodiments, but that various changes, equivalents, and/or alternatives of the embodiments may be included in the invention.
In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention unclear.
The terms used in the specification are defined in consideration of functions used in the present invention, and can be changed according to the intent or conventionally used methods of clients, operators, and users. Accordingly, definitions of the terms should be understood on the basis of the entire description of the present specification.
In the description of the drawings, like reference numerals may be used for similar elements.
The expression of singularity in the present specification includes the expression of plurality unless clearly specified otherwise in context.
As used herein, the expression “A or B”, “A and/or B or at least one of A and B” and the like may include all possible combinations of listed items.
Terms such as “first” and “second” are used herein merely to describe a variety of constituent elements, but the constituent elements are not limited by the terms. The terms are used only for the purpose of distinguishing one constituent element from another constituent element.
It will be understood that when an element (e.g., first) is referred to as being “on”, “connected to” or “coupled to” another element (e.g., second), it may be directly on, connected or coupled to the other element or an intervening element (e.g., third) may be present.
In this specification, the term “configured to” may be used interchangeably with the term “suitable for”, “having ability to”, “modified to”, “made to”, “capable of”, or “designed to” depending on the situation.
In some circumstances, the expression “a device configured to” may mean that the device “can do” with other devices or components.
For example, in the phrase “process configured to perform A, B, and C”, the processor may be a dedicated processor (e.g., embedded processor) for performing the operation, or a general-purpose processor (e.g., CPU or application processor) capable of performing corresponding operations by executing one or more software programs stored in the memory device.
In addition, the expression “or” means “inclusive or” rather than “exclusive or”.
That is, unless otherwise mentioned or clearly inferred from context, the expression “x uses a or b” means any one of natural inclusive permutations.
Specifically, in
Referring to
According to one embodiment of the present invention, the water-soluble substrate 100 may be formed of any one of poly(lactic-co-glycolic acid) (PLGA) and polyvinyl alcohol (PVA).
For example, the water-soluble insulating layer 110 may be deposited on the water-soluble substrate 100 using chemical vapor deposition.
According to one embodiment of the present invention, the water-soluble insulating layer 110 may be formed of an oxide-based layer or a water-soluble polymer complex and may include a water-soluble protective layer.
In addition, the dissolving timing of the water-soluble insulating layer 110 may be controlled depending on the component content of any one of the oxide layer and the water-soluble polymer complex.
For example, the water-soluble insulating layer 110 may be formed of any one of an oxide layer and a water-soluble polymer complex by depositing any one of silicon oxide (SiO2), silicon nitride (Si3N4), hafnium oxide (HfO2), and magnesium oxide (MgO).
In addition, the water-soluble insulating layer 110 may be deposited on the water-soluble substrate 100 using atmospheric pressure chemical vapor deposition (APCVD).
According to one embodiment of the present invention, the electrode layer 120 may be formed of any one of molybdenum (Mo) and magnesium (Mg) and may be formed on the water-soluble insulating layer 110.
For example, the electrode layer 120 may receive biometric data through the channel layer 130.
According to one embodiment of the present invention, the channel layer 130 may be formed on the water-soluble insulating layer 110 to be connected to the electrode layer 120 and may include molybdenum disulfide in particle form.
For example, the channel layer 130 may be deposited as a single layer on the water-soluble insulating layer 110 using metal-organic chemical vapor deposition (MOCVD).
In addition, the channel layer 130 may be deposited by performing electron beam deposition on the electrode layer 120.
According to one embodiment of the present invention, the channel layer 130 may measure at least one of bioabsorbability, pressure, temperature, strain, and acceleration of the living matter.
For example, the channel layer 130 may have a polycrystalline structure and may be deposited as a single-layer film on the water-soluble insulating layer 110.
In addition, the water-soluble insulating layer 110 may be additionally formed on the electrode layer 120 and the channel layer 130 in the same pattern. Here, a structure in which the water-soluble insulating layer 110 is additionally laminated on the electrode layer 120 and the channel layer 130 will be described with reference to
According to one embodiment of the present invention, when the transient sensor is inserted into the living matter, the transient sensor may be dissolved in the living matter within the critical time.
According to the present invention, since the transient sensor using the electronic element is spontaneously dissolved in vivo, a process of re-incising the site where the transient sensor is inserted may be omitted, thereby reducing inconvenience of procedures and improving convenience of a subject.
In addition, procedural costs may be reduced by reducing procedural inconvenience.
For example, the critical time may be determined based on the particle size of the channel layer deposited using metal-organic chemical vapor deposition.
According to one embodiment of the present invention, the transient sensor may include a two-dimensional material.
For example, in addition to molybdenum disulfide (MoS2), the two-dimensional material may include tungsten sulfide (WS2), molybdenum diselenide (MoSe2), tungsten diselenide (WSe2), molybdenum ditelluride (MoTe2), and the like.
For example, to increase the lifespan of the transient sensor using a water-soluble electronic element, after completing manufacture of the sensor, the top layer of the transient sensor may be encapsulated using a polymer material.
According to the present invention, a transient sensor using a water-soluble electronic element insertable into the body may be manufactured. In this case, the transient sensor may be spontaneously dissolved after serving as a sensor.
Referring to
According to one embodiment of the present invention, the channel layer 140 may be deposited by performing electron beam deposition on the electrode layer 150, and may include a channel.
For example, in the channel layer 140, a channel may be deposited in a square wave form, and the channel may be connected to the electrode layer 150. In this case, the channel may be deposited in a square wave form by being patterned in a square wave form.
According to one embodiment of the present invention, the channel layer 140 may collect data such as pressure, temperature, and strain of living matter through the channel.
For example, the channel of the channel layer 140 may be changed based on the particle size of the channel layer 140.
In addition, the channel layer 140 may be present as a face on the electrode layer 150.
Referring to
According to one embodiment of the present invention, the water-soluble insulating layers 210 may be laminated on the water-soluble substrate 200.
For example, the water-soluble insulating layers 210 may be formed by laminating silicon dioxide (SiO2) and may serve as a protective layer between the water-soluble substrate 200 and the electrode layer 220.
In addition, the water-soluble insulating layers 210 may be formed on the water-soluble substrate 200 by depositing an oxide such as silicon dioxide (SiO2) using atmospheric pressure chemical vapor deposition.
For example, the electrode layer 220 may be laminated on the water-soluble insulating layers 210.
For example, the electrode layer 220 may be formed by depositing an oxide such as magnesium oxide (MgO).
According to one embodiment of the present invention, the channel layer 230 may be laminated on the water-soluble insulating layers 210 to be connected to the electrode layer 220.
According to one embodiment of the present invention, the channel layer 230 may be formed in a monolayer film structure.
For example, in the channel layer 230, a channel patterned in a square wave form may be formed.
According to one embodiment of the present invention, the water-soluble insulating layers 210 may be additionally laminated on the electrode layer 220 and the channel layer 230.
That is, the water-soluble insulating layers 210 may be present both above and below the electrode layer 220 and the channel layer 230.
Referring to image 300 of
Referring to image 301 of
Referring to image 302 of
Referring to images 320 to 323 of
That is, when the transient sensor is immersed in bodily fluid corresponding to a weakly basic liquid and incubated at a temperature of 40° C., the shape of the transient sensor is preserved for a certain period of time.
In addition, when culture temperature is increased, the transient sensor is more quickly dissolved.
In
When dissolving time at a first pH 330 is compared with dissolving time at a second pH 340, dissolving time is shortened at a low pH (i.e., the second pH 340), and the dissolving time is shortened as the temperature of an aqueous solution increases.
Image 400 of
Image 401 of
In
Therefore, according to the method of manufacturing a transient sensor using molybdenum disulfide, biocompatibility of the transient sensor may be determined based on the ratio of immune cells present in the peripheral blood.
Specifically,
Referring to
Specifically,
To analyze cytotoxicity by insertion of the transient sensor, a sample sensor having a size of about 3 mm×10 mm is inserted into the muscle tissues of a rat and then cytotoxicity is analyzed.
Therefore, according to the present invention, a transient sensor that has excellent chemical stability and that can be manufactured to have a very thin thickness may be manufactured. According to the present invention, due to the chemical stability of the transient sensor, the transient sensor may not be easily transformed into other substances, and thus in vivo stability thereof may also be excellent. In addition, due to the thin thickness of the transient sensor, the dissolving time of the transient sensor in vivo may be remarkably reduced.
Referring to
Referring to
In the graph, the horizontal axis corresponds to time, and the vertical axis corresponds to temperature. According to the graph, the first and second sensors collect similar data.
That is, the transient sensor according to an embodiment of the present invention has the same data collection capabilities as a commonly used biosensor.
Referring to
That is, according to the method of manufacturing a transient sensor, a water-soluble insulating layer may be formed on a water-soluble substrate formed of any one of poly(lactic-co-glycolic acid) (PLGA) and polyvinyl alcohol (PVA) by depositing any one of silicon oxide (SiO2), silicon nitride (Si3N4), hafnium oxide (HfO2), and magnesium oxide (MgO) based on atmospheric pressure chemical vapor deposition (APCVD).
In step 902, an electrode layer may be formed on a water-soluble insulating layer.
That is, according to the method of manufacturing a transient sensor, the electrode layer may be formed by depositing any one of molybdenum and magnesium (Mg) on the water-soluble insulating layer using chemical vapor deposition.
In step 903, a channel layer may be formed on the water-soluble insulating layer to be connected to the electrode layer.
That is, according to the method of manufacturing a transient sensor, the channel layer may be formed on the water-soluble insulating layer using molybdenum disulfide.
In step 904, the transient sensor that is dissolved within a critical time in living matter may be manufactured.
That is, according to the method of manufacturing a transient sensor, the transient sensor may include the water-soluble substrate, the water-soluble insulating layer, the electrode layer, and the channel layer. When the transient sensor is inserted into living matter, the transient sensor may be dissolved within a critical time in the living matter.
In addition, the method of manufacturing a transient sensor may further include a step of measuring at least one of bioabsorbability, pressure, temperature, strain, and acceleration of living matter through the channel layer.
In addition, the method of manufacturing a transient sensor may further include a step of determining biocompatibility of the channel layer based on the ratio of immune cells present in the peripheral blood of living matter into which the transient sensor is inserted and based on change in weight of the living matter.
Therefore, the present invention may provide a method of manufacturing a transient sensor. According to the present invention, the method may improve economic efficiency in lab-on-a-chip and wearable electronic device fields and may contribute to leading research on bio-nanomaterials
In the above-described specific embodiments, elements included in the invention have been expressed singular or plural in accordance with the specific embodiments shown.
However, for ease of explanation, the singular or plural expressions are appropriately selected in accordance with the situation. The above-described embodiments are not limited to the singular or plural representations. Components expressed in plural forms may be in singular form, and vice versa.
In addition, although the present invention has been described with reference to specific embodiments, various modifications are possible without departing from the scope of the technical idea contained in the various embodiments.
Therefore, it should be understood that there is no intent to limit the invention to the embodiments disclosed, rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the claims.
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Number | Date | Country | |
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