Claims
- 1. A method of treating an LFA-1 or a TNF-α mediated disorder, comprising administering to a mammal in need thereof effective amounts of an LFA-1 antagonist and a TNF-α antagonist.
- 2. A method of treating cartilage damage from injury or preventing initial or continued damage by a degenerative cartilagenous disorder or injury, comprising contacting the cartilage with effective amounts of an LFA-1 antagonist and a TNF-α antagonist.
- 3. The method of claim 1 or 2, wherein the disorder is a degenerative cartilagenous disorder.
- 4. The method of claim 3, wherein the degenerative cartilagenous disorder is selected from the group consisting of rheumatoid arthritis and osteoarthritis.
- 5. The method of one of claims 1-4, wherein the LFA-1 antagonist is an anti-LFA-1 antibody, preferably an anti-CD11a antibody.
- 6. The method of one of claims 1-5, wherein the LFA-1 antagonist is a non T-cell depleting anti-CD11a antibody.
- 7. The method of one of claims 1-6, wherein the TNF-α antagonist is an immunoadhesin.
- 8. The method of one of claim 7 wherein the immunoadhesin is a fusion of at least a portion of a TNF-α binding protein and a portion of an immunoglobulin.
- 9. The method of one of claim 8, wherein the TNF-α binding protein is a TNF-α receptor—IgG Fc fusion protein.
- 10. A composition, comprising an LFA-1 antagonist and a TNF-α antagonist.
- 11. The composition of claim 10, wherein the LFA-1 antagonist is an anti-LFA-1 antibody
- 12. The composition of claim 11, wherein the anti-LFA-1 antibody is an anti-CD11a antibody.
- 13. The composition of claim 12, wherein the an anti-CD11a antibody is a non T-cell depleting antibody.
- 14. The composition of claim 10, wherein the TNF-α antagonist is an immunoadhesin.
- 15. The composition of claim 14, wherein the immunoadhesin is a fusion of at least a portion of a TNF-α binding protein and a portion of an immunoglobulin.
- 16. The composition of claim 15, wherein the TNF-α binding protein is a TNF-α receptor—IgG Fc fusion protein.
Parent Case Info
[0001] This application claims the benefit under 1.19(e) to provisional application 60/170,696 filed Dec. 14, 1999.
Provisional Applications (1)
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Number |
Date |
Country |
|
60170696 |
Dec 1999 |
US |