Immunoglobulins specific feautures

CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES

C07K2317/00Immunoglobulins specific feautures

C07K2317/10characterized by their source of isolation or production C07K2317/11isolated from eggs C07K2317/12isolated from milk C07K2317/13isolated from plants C07K2317/14Specific host cells or culture conditions C07K2317/20characterized by taxonomic origin C07K2317/21from primates C07K2317/22from camelids C07K2317/23from birds C07K2317/24containing regions, domains or residues from different species C07K2317/30characterized by aspects of specificity or valency C07K2317/31multispecific C07K2317/32specific for a neo-epitope on a complex C07K2317/33Crossreactivity C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues C07K2317/35Valency C07K2317/40characterized by post-translational modification C07K2317/41Glycosylation, sialylation, or fucosylation C07K2317/50characterized by immunoglobulin fragments C07K2317/51Complete heavy chain or Fd fragment C07K2317/515Complete light chain C07K2317/52Constant or Fc region Isotype C07K2317/522CH1 domain C07K2317/524CH2 domain C07K2317/526CH3 domain C07K2317/528CH4 domain C07K2317/53Hinge C07K2317/54F(ab')2 C07K2317/55Fab or Fab' C07K2317/56variable (Fv) region C07K2317/565Complementarity determining region [CDR] C07K2317/567Framework region [FR] C07K2317/569Single domain C07K2317/60characterized by non-natural combinations of immunoglobulin fragments C07K2317/62comprising only variable region components C07K2317/622Single chain antibody (scFv) C07K2317/624Disulfide-stabilized antibody (dsFv) C07K2317/626Diabody or triabody C07K2317/64comprising a combination of variable region and constant region components C07K2317/66comprising a swap of domains C07K2317/70characterized by effect upon binding to a cell or to an antigen C07K2317/71Decreased effector function due to an Fc-modification C07K2317/72Increased effector function due to an Fc-modification C07K2317/73Inducing cell death C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC] C07K2317/734Complement-dependent cytotoxicity [CDC] C07K2317/74Inducing cell proliferation C07K2317/75Agonist effect on antigen C07K2317/76Antagonist effect on antigen C07K2317/77Internalization into the cell C07K2317/80remaining in the (producing) cell C07K2317/81functional in the endoplasmatic reticulum [ER] or the Golgi apparatus C07K2317/82functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria C07K2317/90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value C07K2317/94Stability