Oligo-1,6-glucosidase (3.2.1.10)

Industry

CPC
C12Y302/0101

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Parent Industries

CCHEMISTRY METALLURGY C12Biochemistry C12YENZYMES C12Y302/00Hydrolases acting on glycosyl compounds

Current Industry

C12Y302/0101Oligo-1,6-glucosidase (3.2.1.10)

Industries

Patents Grantslast 30 patents

Information Patent Grant
Use of lysin to restore/augment antibacterial activity in the prese...
- Patent number 12,144,845
- Issue date Nov 19, 2024
- AUROBAC THERAPEUTICS SAS
- Michael Wittekind
- Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMA...
Information Patent Grant
Animal feed compositions and uses thereof
- Patent number 12,133,542
- Issue date Nov 5, 2024
- Novozymes A/S
- Rual Lopez-Ulibarri
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Engineered influenza polynucleotides, viruses, vaccines and methods...
- Patent number 12,133,888
- Issue date Nov 5, 2024
- Duke University
- Nicholas Scott Heaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Identification of lysins and derivatives thereof with bactericidal...
- Patent number 12,121,568
- Issue date Oct 22, 2024
- AUROBAC THERAPEUTICS SAS
- Raymond Schuch
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polypeptide variants
- Patent number 12,116,553
- Issue date Oct 15, 2024
- The Procter & Gamble Company
- Lars Beier
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Spherical agglomeration of proteins
- Patent number 12,110,519
- Issue date Oct 8, 2024
- Purdue Research Foundation
- Zoltan K. Nagy
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polypeptides and antibiotics against gram-negative bacterium compri...
- Patent number 12,102,667
- Issue date Oct 1, 2024
- LYSENTECH CO., LTD.
- Heejoon Myung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Composition of complex enzyme-probiotic and its applications into a...
- Patent number 12,102,099
- Issue date Oct 1, 2024
- Khai Minh Viet Enzyme Technology JSC
- Anh Quynh Nguyen
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Chimeric endolysin polypeptide
- Patent number 12,091,691
- Issue date Sep 17, 2024
- Micreos Pharmaceuticals AG
- Mathias Schmelcher
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Site-specific crosslinking of antibodies
- Patent number 12,071,487
- Issue date Aug 27, 2024
- Life Technologies Corporation
- Brian Agnew
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of protecting a plant from a fungal pest
- Patent number 12,070,038
- Issue date Aug 27, 2024
- Novozymes BioAg A/S
- Brian R. Scott
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Microbial lysozyme for use in the treatment of irritable bowel synd...
- Patent number 12,053,509
- Issue date Aug 6, 2024
- Novozymes A/S
- Soeren Kjaerulff
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Amino-reactive positively charged ATRP initiators that maintain the...
- Patent number 12,053,529
- Issue date Aug 6, 2024
- Carnegie Mellon University
- Alan J. Russell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chitinase proteins in neurologic disease
- Patent number 12,050,217
- Issue date Jul 30, 2024
- Dignity Health
- Robert Bowser
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Engineered influenza antigenic polypeptides and immunogenic composi...
- Patent number 12,037,364
- Issue date Jul 16, 2024
- Sanofi Pasteur Inc.
- Tod Strugnell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vectors, genetically modified bacteria, and methods of making and u...
- Patent number 11,965,190
- Issue date Apr 23, 2024
- Regents of The University of Minnesota
- Yiannis John Kaznessis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Antimicrobial proteins
- Patent number 11,958,890
- Issue date Apr 16, 2024
- Lysando AG
- Manfred Biebl
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Control of coleopteran pests using RNA molecules
- Patent number 11,945,843
- Issue date Apr 2, 2024
- Syngenta Participations AG
- Kevin L. Donohue
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for treating mucosal tissue disorders
- Patent number 11,938,166
- Issue date Mar 26, 2024
- The University of North Carolina at Chapel Hill
- Roland R. Arnold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Hay preservative and methods for preservation of hay
- Patent number 11,903,397
- Issue date Feb 20, 2024
- Danstar Ferment AG
- Julien Sindou
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Polypeptides having lysozyme activity, polynucleotides encoding sam...
- Patent number 11,896,033
- Issue date Feb 13, 2024
- Novozymes A/S
- Mikkel Klausen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Polypeptides having lysozyme activity, polynucleotides encoding sam...
- Patent number 11,896,034
- Issue date Feb 13, 2024
- Novozymes A/S
- Mikkel Klausen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Endolysins active against Bacillus bacteria, pharmaceutical composi...
- Patent number 11,890,330
- Issue date Feb 6, 2024
- University of Maryland, College Park
- Daniel C. Nelson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for treating age-related diseases
- Patent number 11,891,442
- Issue date Feb 6, 2024
- The Board of Trustees of the Leland Stanford Junior University
- Anton Wyss-Coray
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chromatography membranes, devices containing them, and methods of u...
- Patent number 11,884,701
- Issue date Jan 30, 2024
- Merck Millipore Ltd.
- Damian Brellisford
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Polypeptides having lysozyme activity, polynucleotides encoding sam...
- Patent number 11,859,170
- Issue date Jan 2, 2024
- Novozymes A/S
- Ye Liu
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Methods and compositions for biopreservation
- Patent number 11,849,722
- Issue date Dec 26, 2023
- THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE NC
- Susan Trammell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chimeric endolysin LYS109 with antimicrobial activity against staph...
- Patent number 11,827,912
- Issue date Nov 28, 2023
- Seoul National University R&DB Foundation
- Sangryeol Ryu
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Polypeptide, fusion polypeptide, and antibiotic against gram-negati...
- Patent number 11,807,881
- Issue date Nov 7, 2023
- LYSENTECH CO., LTD.
- Heejoon Myung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant extracellular chitinase from Brevibacillus laterosporus...
- Patent number 11,807,880
- Issue date Nov 7, 2023
- Council of Scientific and Industrial Research
- Lakshmi Prasanna Gangavaramu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
Site-Specific Crosslinking of Antibodies
- Publication number 20240392041
- Publication date Nov 28, 2024
- Life Technologies Corporation
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LAUNDRY COMPOSITIONS FOR CLEANING
- Publication number 20240384205
- Publication date Nov 21, 2024
- Danisco US Inc.
- Jonathan Lassila
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Application
METHODS OF PROTECTING A PLANT FROM A FUNGAL PEST
- Publication number 20240365791
- Publication date Nov 7, 2024
- Novozymes BioAg A/S
- Brian R. Scott
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Engineered Expression of Cell Surface and Secreted Sialidase by CAR...
- Publication number 20240368546
- Publication date Nov 7, 2024
- The Trustees of the University of Pennsylvania
- Avery D. Posey
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RAPID EXPRESSION AND PURIFICATION OF THERMOSTABLE PROTEINS INCLUDIN...
- Publication number 20240352432
- Publication date Oct 24, 2024
- DUKE UNIVERSITY
- Michael Lynch
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EDIBLE PLANT-BASED PROTEIN COMPOSITION
- Publication number 20240349755
- Publication date Oct 24, 2024
- MEALA FOODTECH LTD
- Liran GARUDA
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
TRUNCATED INFLUENZA NEURAMINIDASE AND METHODS OF USING THE SAME
- Publication number 20240335525
- Publication date Oct 10, 2024
- SANOFI PASTEUR INC.
- Mario BARRO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Microbial Lysozyme for use in the Treatment of Irritable Bowel Synd...
- Publication number 20240325508
- Publication date Oct 3, 2024
- NOVOZYMES A/S
- Soeren Kjaerulff
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VIRAL DELIVERY OF A SIALIDASE TO TREAT CANCER
- Publication number 20240299582
- Publication date Sep 12, 2024
- UNIVERSITAT BASEL
- Heinz LÄUBLI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHITINASE PROTEINS IN NEUROLOGIC DISEASE
- Publication number 20240302372
- Publication date Sep 12, 2024
- DIGNITY HEALTH
- Robert Bowser
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Chimeric endolysin polypeptide, cluster 3b
- Publication number 20240293517
- Publication date Sep 5, 2024
- Micreos Pharmaceuticals AG
- Fritz EICHENSEHER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES
- Publication number 20240287175
- Publication date Aug 29, 2024
- The Board of Trustees of the Leland Stanford Junior University
- Anton Wyss-Coray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CHITINOLYTIC ENZYME-BASED PLANT PROTECTION AGENTS
- Publication number 20240287489
- Publication date Aug 29, 2024
- GLOBACHEM NV
- Guy VAN DAELE
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
COMPOSITIONS AND METHODS FOR ENHANCING CAR T CELL EFFICACY THROUGH...
- Publication number 20240285757
- Publication date Aug 29, 2024
- The Trustees of the University of Pennsylvania
- Joseph Durgin
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ACHOLETIN BIOPOLYMERS AND METHODS FOR ENZYMATIC SYNTHESIS
- Publication number 20240287564
- Publication date Aug 29, 2024
- The University of British Columbia
- Stephen G. Withers
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL SIALIDASES AND USES THEREOF
- Publication number 20240287488
- Publication date Aug 29, 2024
- The Regents of the University of California
- Karsten Zengler
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NUCLEIC ACID MOLECULES
- Publication number 20240277834
- Publication date Aug 22, 2024
- AstraZeneca AB
- Albert George THOM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Chimeric endolysin polypeptide
- Publication number 20240279631
- Publication date Aug 22, 2024
- Micreos Pharmaceuticals AG
- Mathias Schmelcher
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS TO GLYCOENGINEER PROTEINS
- Publication number 20240279328
- Publication date Aug 22, 2024
- The Johns Hopkins University
- Kevin J. Yarema
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DEVICE AND METHODS FOR ACNE THERAPEUTICS: ANTIBACTERIAL BACTERIOPHA...
- Publication number 20240277791
- Publication date Aug 22, 2024
- Integrated Pharma Services, LLC
- Mina Izadjoo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED POLYPEPTIDE HAVING LYSOZYME ACTIVITY
- Publication number 20240218413
- Publication date Jul 4, 2024
- CJ CHEILJEDANG CORPORATION
- Kyung-Chang LEE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENGINEERED INFLUENZA VIRUSES EXPRESSING SARS-COV-2 ANTIGENS, VACCIN...
- Publication number 20240207391
- Publication date Jun 27, 2024
- DUKE UNIVERSITY
- Nicholas Heaton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
THERMOPLASTIC BIODEGRADABLE ELASTOMERS AND METHODS OF USE
- Publication number 20240199793
- Publication date Jun 20, 2024
- Regents of the University of Minnesota
- Wei Shen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SIGNAL PEPTIDES
- Publication number 20240197921
- Publication date Jun 20, 2024
- Imperial College Innovations Limited
- Jack HICKMOTT
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INFANT FORMULA
- Publication number 20240196949
- Publication date Jun 20, 2024
- John KAPELERIS
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
SIALYDASE LINKED HIV ANTIBODIES AND METHODS OF USE
- Publication number 20240181051
- Publication date Jun 6, 2024
- The Wistar Institute of Anatomy and Biology
- Mohamed Abdel-Mohsen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Protein Deposition Method For Detecting Protein Removal Effect, Pro...
- Publication number 20240176133
- Publication date May 30, 2024
- SUZHOU 3N BIOLOGICAL TECHNOLOGY CO., LTD
- Ruichun SUN
- B08 - CLEANING
Information Patent Application
METHODS FOR SEPARATING PLANT MATTER INTO ANATOMICAL STRUCTURES
- Publication number 20240158817
- Publication date May 16, 2024
- Battelle Energy Alliance, LLC
- Bradley D. Wahlen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANIMAL FEED COMPOSITION AND USE THEREOF
- Publication number 20240156921
- Publication date May 16, 2024
- DSM IP Assets B. V.
- Wolfgang Schliffka
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DIAGNOSTIC ALGORITHMS FOR DETERMINING AND TREATING CLINICALLY SIGNI...
- Publication number 20240151727
- Publication date May 9, 2024
- HIGH DEVELOPMENT LIMITED
- John Klassen
- G01 - MEASURING TESTING

Oligo-1,6-glucosidase (3.2.1.10)

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Use of lysin to restore/augment antibacterial activity in the prese...

Animal feed compositions and uses thereof

Engineered influenza polynucleotides, viruses, vaccines and methods...

Identification of lysins and derivatives thereof with bactericidal...

Polypeptide variants

Spherical agglomeration of proteins

Polypeptides and antibiotics against gram-negative bacterium compri...

Composition of complex enzyme-probiotic and its applications into a...

Chimeric endolysin polypeptide

Site-specific crosslinking of antibodies

Methods of protecting a plant from a fungal pest

Microbial lysozyme for use in the treatment of irritable bowel synd...

Amino-reactive positively charged ATRP initiators that maintain the...

Chitinase proteins in neurologic disease

Engineered influenza antigenic polypeptides and immunogenic composi...

Vectors, genetically modified bacteria, and methods of making and u...

Antimicrobial proteins

Control of coleopteran pests using RNA molecules

Methods and compositions for treating mucosal tissue disorders

Hay preservative and methods for preservation of hay

Polypeptides having lysozyme activity, polynucleotides encoding sam...

Polypeptides having lysozyme activity, polynucleotides encoding sam...

Endolysins active against Bacillus bacteria, pharmaceutical composi...

Compositions and methods for treating age-related diseases

Chromatography membranes, devices containing them, and methods of u...

Polypeptides having lysozyme activity, polynucleotides encoding sam...

Methods and compositions for biopreservation

Chimeric endolysin LYS109 with antimicrobial activity against staph...

Polypeptide, fusion polypeptide, and antibiotic against gram-negati...

Recombinant extracellular chitinase from Brevibacillus laterosporus...

Patents Applicationslast 30 patents

Site-Specific Crosslinking of Antibodies

LAUNDRY COMPOSITIONS FOR CLEANING

METHODS OF PROTECTING A PLANT FROM A FUNGAL PEST

Engineered Expression of Cell Surface and Secreted Sialidase by CAR...

RAPID EXPRESSION AND PURIFICATION OF THERMOSTABLE PROTEINS INCLUDIN...

EDIBLE PLANT-BASED PROTEIN COMPOSITION

TRUNCATED INFLUENZA NEURAMINIDASE AND METHODS OF USING THE SAME

Microbial Lysozyme for use in the Treatment of Irritable Bowel Synd...

VIRAL DELIVERY OF A SIALIDASE TO TREAT CANCER

CHITINASE PROTEINS IN NEUROLOGIC DISEASE

Chimeric endolysin polypeptide, cluster 3b

COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES

CHITINOLYTIC ENZYME-BASED PLANT PROTECTION AGENTS

COMPOSITIONS AND METHODS FOR ENHANCING CAR T CELL EFFICACY THROUGH...

ACHOLETIN BIOPOLYMERS AND METHODS FOR ENZYMATIC SYNTHESIS

NOVEL SIALIDASES AND USES THEREOF

NUCLEIC ACID MOLECULES

Chimeric endolysin polypeptide

METHODS TO GLYCOENGINEER PROTEINS

DEVICE AND METHODS FOR ACNE THERAPEUTICS: ANTIBACTERIAL BACTERIOPHA...

MODIFIED POLYPEPTIDE HAVING LYSOZYME ACTIVITY

ENGINEERED INFLUENZA VIRUSES EXPRESSING SARS-COV-2 ANTIGENS, VACCIN...

THERMOPLASTIC BIODEGRADABLE ELASTOMERS AND METHODS OF USE

SIGNAL PEPTIDES

INFANT FORMULA

SIALYDASE LINKED HIV ANTIBODIES AND METHODS OF USE

Protein Deposition Method For Detecting Protein Removal Effect, Pro...

METHODS FOR SEPARATING PLANT MATTER INTO ANATOMICAL STRUCTURES

ANIMAL FEED COMPOSITION AND USE THEREOF

DIAGNOSTIC ALGORITHMS FOR DETERMINING AND TREATING CLINICALLY SIGNI...