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Stable introduction of foreign DNA into chromosome
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C12N15/90
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C12
Biochemistry
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MICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA
C12N15/00
Mutation or genetic engineering DNA or RNA concerning genetic engineering, vectors
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C12N15/90
Stable introduction of foreign DNA into chromosome
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Patents Grants
last 30 patents
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Patent Grant
CFTR-modulating compositions and methods
Patent number
12,270,029
Issue date
Apr 8, 2025
FLAGSHIP PIONEERING INNOVATIONS VI, LLC
Robert Charles Altshuler
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Engineered multi-component system for identification and characteri...
Patent number
12,270,047
Issue date
Apr 8, 2025
GENOVIE AB
Reagan Micheal Jarvis
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Quinoxalinone compounds, compositions, methods, and kits for increa...
Patent number
12,269,804
Issue date
Apr 8, 2025
Vertex Pharmaceuticals Incorporated
Sudipta Mahajan
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Compositions and methods for targeting, editing, or modifying genes
Patent number
12,270,043
Issue date
Apr 8, 2025
Celyntra Therapeutics SA
Andrea Barghetti
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Engineered microorganisms expressing acetoacetyl-COA reductase vari...
Patent number
12,270,024
Issue date
Apr 8, 2025
SHENZHEN BLUEPHA BIOSCIENCES CO., LTD.
Jin Yin
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Methods and kits for identifying cancer treatment targets
Patent number
12,270,027
Issue date
Apr 8, 2025
The Regents of the University of California
Jennifer A. Doudna
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
CRISPR systems with engineered dual guide nucleic acids
Patent number
12,270,044
Issue date
Apr 8, 2025
Celyntra Therapeutics SA
Ryan T. Gill
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Compositions and methods for treating non-age-associated hearing im...
Patent number
12,264,317
Issue date
Apr 1, 2025
Akouos, Inc.
Emmanuel John Simons
A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
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Patent Grant
Recombinant type I CRISPR-Cas system and uses thereof for killing t...
Patent number
12,264,330
Issue date
Apr 1, 2025
North Carolina State University
Rodolphe Barrangou
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Methods of in vivo evaluation of gene function
Patent number
12,264,367
Issue date
Apr 1, 2025
The Broad Institute, Inc.
Xin Jin
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Nucleic acid binding domains and methods of use thereof
Patent number
12,264,181
Issue date
Apr 1, 2025
Altius Institute for Biomedical Sciences
John A. Stamatoyannopoulos
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Systems and methods for one-shot guide RNA (ogRNA) targeting of end...
Patent number
12,264,331
Issue date
Apr 1, 2025
Editas Medicine, Inc.
Ari E. Friedland
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
CRISPR-Cas enzymes with enhanced on-target activity
Patent number
12,264,341
Issue date
Apr 1, 2025
The General Hospital Corporation
Benjamin Kleinstiver
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Cas proteins with reduced immunogenicity and methods of screening t...
Patent number
12,258,594
Issue date
Mar 25, 2025
The Broad Institute, Inc.
Feng Zhang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Systems, methods and compositions for sequence manipulation with op...
Patent number
12,258,595
Issue date
Mar 25, 2025
The Broad Institute, Inc.
Silvana Konermann
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
RNA-guided nucleic acid modifying enzymes and methods of use thereof
Patent number
12,258,575
Issue date
Mar 25, 2025
The Regents of the University of California
Jennifer A. Doudna
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Systems targeting PSMA and CA9
Patent number
12,257,304
Issue date
Mar 25, 2025
ARSENAL BIOSCIENCES, INC.
Angela Boroughs
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Method for generating t-cells compatible for allogenic transplantation
Patent number
12,252,699
Issue date
Mar 18, 2025
Cellectis
Laurent Poirot
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
RNA-guided nucleases and active fragments and variants thereof and...
Patent number
12,252,706
Issue date
Mar 18, 2025
Life Edit Therapeutics, Inc.
Tyson D. Bowen
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Delivery, Engineering and optimization of systems, methods and comp...
Patent number
12,252,707
Issue date
Mar 18, 2025
The Broad Institute, Inc.
Feng Zhang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Small type II-D Cas proteins and methods of use thereof
Patent number
12,252,705
Issue date
Mar 18, 2025
The Broad Institute, Inc.
Feng Zhang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Methods and compositions for RNA-guided treatment of HIV infection
Patent number
12,251,429
Issue date
Mar 18, 2025
Temple University - of the Commonwealth System of Higher Education
Kamel Khalili
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Genetically engineered hematopoietic stem cells and uses thereof
Patent number
12,251,403
Issue date
Mar 18, 2025
VOR BIOPHARMA INC.
Joseph Bolen
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Materials and methods for treatment of autosomal dominant retinitis...
Patent number
12,247,201
Issue date
Mar 11, 2025
CRISPR THERAPEUTICS AG
Albena Kantardzhieva
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Efficient TCR gene editing in T lymphocytes
Patent number
12,239,664
Issue date
Mar 4, 2025
Genentech, Inc.
Sascha Rutz
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Humanized IL-6 and IL-6 receptor
Patent number
12,239,111
Issue date
Mar 4, 2025
REGENERON PHARMACEUTICALS, INC.
Li-Hsien Wang
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
Patent number
12,241,096
Issue date
Mar 4, 2025
The General Hospital Corporation
J. Keith Joung
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
B cell receptor modification in B cells
Patent number
12,241,081
Issue date
Mar 4, 2025
The Scripps Research Institute
James Even Voss
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Regulation of transcription through CTCF loop anchors
Patent number
12,234,453
Issue date
Feb 25, 2025
Whitehead Institute for Biomedical Research
Jurian Schuijers
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Targeted non-viral DNA insertions
Patent number
12,234,461
Issue date
Feb 25, 2025
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION
Theodore Lee Roth
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Patents Applications
last 30 patents
Information
Patent Application
COMPOSITIONS AND METHODS FOR CELL ENGINEERING FOR MEAT PRODUCTION
Publication number
20250115875
Publication date
Apr 10, 2025
Fork & Goode, Inc.
Bryan J. Gonzalez
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
THERAPEUTIC APPLICATIONS OF CPF1-BASED GENOME EDITING
Publication number
20250114482
Publication date
Apr 10, 2025
DUKE UNIVERSITY
Charles A. Gersbach
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
ENGINEERED MULTIPARTITE TRANSCRIPTIONAL EFFECTORS SOURCED FROM HUMA...
Publication number
20250115935
Publication date
Apr 10, 2025
William Marsh Rice University
Isaac HILTON
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
MODIFIED VERO CELLS AND METHODS OF USING THE SAME FOR VIRUS PRODUCTION
Publication number
20250115881
Publication date
Apr 10, 2025
Sanofi Pasteur
MARIE-ANGÉLIQUE ND¿YE, YANDÉ S¿NE
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
HAPLOTYPE-BASED TREATMENT OF RP1 ASSOCIATED RETINAL DEGENERATIONS
Publication number
20250115887
Publication date
Apr 10, 2025
Massachusetts Eye and Ear Infirmary
Qin Liu
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES
Publication number
20250115901
Publication date
Apr 10, 2025
THE BROAD INSTITUTE, INC.
David R. Liu
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SYSTEM AND METHOD FOR EDITING GENOMIC DNA TO MODULATE SPLICING
Publication number
20250115934
Publication date
Apr 10, 2025
Eberhard Karls Universität Tübingen Medizinische Fakultät
Pietro DE ANGELI
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENETICALLY MODIFIED MOUSE MODELS AND METHODS OF USE THEREOF
Publication number
20250113809
Publication date
Apr 10, 2025
University of South Florida
Lianchun Wang
A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
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Patent Application
GENERATION OF INDUCED PLURIPOTENT CELLS BY CRISPR ACTIVATION
Publication number
20250115877
Publication date
Apr 10, 2025
The J. David Gladstone Institutes, a Testamentary Trust Established Under the...
Peng Liu
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENOME EDITING WITH CRISPR/CAS NUCLEASES COMPRISING COLLATERAL ACTI...
Publication number
20250115933
Publication date
Apr 10, 2025
Sartorius Stedim Cellca GmbH
Paul Scholz
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPOSITIONS AND METHODS FOR EDITING GENOMES
Publication number
20250115903
Publication date
Apr 10, 2025
DANMARKS TEKNISKE UNIVERSITET
Ryan T. Gill
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
Method for Producing Genetically Modified Cells
Publication number
20250109413
Publication date
Apr 3, 2025
Rutgers, The State University of New Jersey
Shengkan Jin
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
METHODS OF SUBSTITUTING PATHOGENIC AMINO ACIDS USING PROGRAMMABLE B...
Publication number
20250108098
Publication date
Apr 3, 2025
Beam Therapeutics Inc.
David Bryson
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
Improved Probiotic Potency of the Yeast Saccharomyces Boulardii
Publication number
20250108081
Publication date
Apr 3, 2025
VIB VZW
Johan Thevelein
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
S. PYOGENES CAS9 MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME
Publication number
20250109395
Publication date
Apr 3, 2025
Integrated DNA Technologies, Inc.
Christopher Anthony Vakulskas
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPOSITIONS AND METHODS FOR TREATMENT OF ANEUPLOID CANCERS
Publication number
20250102493
Publication date
Mar 27, 2025
Yale University
Jason Sheltzer
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
METHODS OF AND COMPOSITIONS FOR REDUCING GENE EXPRESSION AND/OR ACT...
Publication number
20250099556
Publication date
Mar 27, 2025
Christiana Care Gene Editing Institute, Inc.
Eric B. Kmiec
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENETICALLY MODIFIED CELLS AND COMPOSITIONS AND USES THEREOF
Publication number
20250101382
Publication date
Mar 27, 2025
Sana Biotechnology, Inc.
Charles E. MURRY
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
INTEGRASES
Publication number
20250101403
Publication date
Mar 27, 2025
Seamless Therapeutics GmbH
Aksana SCHNEIDER
C40 - COMBINATORIAL CHEMISTRY
Information
Patent Application
PREPARATION TECHNIQUE FOR UNIVERSAL CAR-T CELL, AND USE OF UNIVERSA...
Publication number
20250101467
Publication date
Mar 27, 2025
CHONGQING PRECISION BIOTECH CO., LTD.
Wuling LI
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITION...
Publication number
20250101468
Publication date
Mar 27, 2025
THE BROAD INSTITUTE, INC.
Feng ZHANG
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
Nuclease-Independent Targeted Gene Editing Platform and Uses Thereof
Publication number
20250101464
Publication date
Mar 27, 2025
Rutgers, The State University of New Jersey
Shengkan Jin
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
METHOD OF EDITING NUCLEIC ACID
Publication number
20250101466
Publication date
Mar 27, 2025
Academisch Ziekenhuis Leiden a/u Leiden University Medical Center
Zhihan ZHAO
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
BASE EDITOR AND THE USE THEREOF
Publication number
20250101469
Publication date
Mar 27, 2025
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Caixia GAO
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
USE OF TCR-DEFICIENT CAR-TREGS IN COMBINATION WITH ANTI-TCR COMPLEX...
Publication number
20250099584
Publication date
Mar 27, 2025
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Julien ZUBER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
EVOLVED CAS14A1 VARIANTS, COMPOSITIONS, AND METHODS OF MAKING AND U...
Publication number
20250101395
Publication date
Mar 27, 2025
THE BROAD INSTITUTE, INC.
David R. Liu
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
ADENO-ASSOCIATED VIRUS COMPOSITIONS AND METHODS OF USE THEREOF
Publication number
20250101465
Publication date
Mar 27, 2025
CITY OF HOPE
Saswati Chatterjee
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Application
CAS ENDONUCLEASES AND RELATED METHODS
Publication number
20250092375
Publication date
Mar 20, 2025
Flagship Pioneering Innovations VII, LLC
Molly Krisann GIBSON
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
SYSTEMS, METHODS, AND COMPOSITIONS FOR SITE-SPECIFIC GENETIC ENGINE...
Publication number
20250092390
Publication date
Mar 20, 2025
Massachusetts Institute of Technology
Omar Abudayyeh
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Application
METHOD FOR SYNTHESIS, ASSEMBLY AND FUNCTION TEST OF ARTIFICIAL CHLO...
Publication number
20250092407
Publication date
Mar 20, 2025
Shenzhen University
Zhangli HU
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...