EVOLVED CAS9 PROTEINS FOR GENE EDITING

REFERENCE TO A SEQUENCE LISTING SUBMITTED AS A TEXT FILE VIA EFS-WEB

The present application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2022, is named H082470224US02-SUBSEQ-EPG and is 3,977,840 bytes in size.

BACKGROUND OF THE INVENTION

Targeted editing of nucleic acid sequences, for example, the targeted cleavage or the targeted introduction of a specific modification into genomic DNA, is a highly promising approach for the study of gene function and also has the potential to provide new therapies for human genetic diseases.¹An ideal nucleic acid editing technology possesses three characteristics: (1) high efficiency of installing the desired modification; (2) minimal off-target activity; and (3) the ability to be programmed to edit precisely any site in a given nucleic acid, e.g., any site within the human genome.²Current genome engineering tools, including engineered zinc finger nucleases (ZFNs),³transcription activator like effector nucleases (TALENs),⁴and most recently, the RNA-guided DNA endonuclease Cas9,5 effect sequence-specific DNA cleavage in a genome. This programmable cleavage can result in mutation of the DNA at the cleavage site via non-homologous end joining (NHEJ) or replacement of the DNA surrounding the cleavage site via homology-directed repair (HDR).^6,7

One drawback of the current technologies is that both NHEJ and HDR are stochastic processes that typically result in modest gene editing efficiencies as well as unwanted gene alterations that can compete with the desired alteration.⁸Since many genetic diseases in principle can be treated by effecting a specific nucleotide change at a specific location in the genome (for example, a C to T change in a specific codon of a gene associated with a disease),⁹the development of a programmable way to achieve such precise gene editing would represent both a powerful new research tool, as well as a potential new approach to gene editing-based human therapeutics.

Another drawback of current genome engineering tools is that they are limited with respect to the DNA sequences that can be targeted. When using ZNFs or TALENS, a new protein must be generated for each individual target sequence. While Cas9 can be targeted to virtually any target sequence by providing a suitable guide RNA, Cas9 technology is still limited with respect to the sequences that can be targeted by a strict requirement for a protospacer-adjacent motif (PAM), typically of the nucleotide sequence 5′-NGG-3′, that must be present immediately adjacent to the 3′-end of the targeted DNA sequence in order for the Cas9 protein to bind and act upon the target sequence. The PAM requirement thus limits the sequences that can be efficiently targeted by Cas9 proteins.

SUMMARY OF THE INVENTION

Significantly, 80-90% of protein mutations responsible for human disease arise from the substitution, deletion, or insertion of only a single nucleotide.⁶Most current strategies for single-base gene correction include engineered nucleases (which rely on the creation of double-strand breaks, DSBs, followed by stochastic, inefficient homology-directed repair, HDR), and DNA-RNA chimeric oligonucleotides.²²The latter strategy involves the design of a RNA/DNA sequence to base pair with a specific sequence in genomic DNA except at the nucleotide to be edited. The resulting mismatch is recognized by the cell's endogenous repair system and fixed, leading to a change in the sequence of either the chimera or the genome. Both of these strategies suffer from low gene editing efficiencies and unwanted gene alterations, as they are subject to both the stochasticity of HDR and the competition between HDR and non-homologous end-joining, NHEJ.^23-25HDR efficiencies vary according to the location of the target gene within the genome,²⁶the state of the cell cycle,²⁷and the type of cell/tissue.²⁸The development of a direct, programmable way to install a specific type of base modification at a precise location in genomic DNA with enzyme-like efficiency and no stochasticity therefore represents a powerful new approach to gene editing-based research tools and human therapeutics.

The clustered regularly interspaced short palindromic repeat (CRISPR) system is a recently discovered prokaryotic adaptive immune system¹⁰that has been modified to enable robust and general genome engineering in a variety of organisms and cell lines.¹¹CRISPR-Cas (CRISPR-associated) systems are protein-RNA complexes that use an RNA molecule (sgRNA) as a guide to localize the complex to a target DNA sequence via base-pairing.¹²In the natural systems, a Cas protein then acts as an endonuclease to cleave the targeted DNA sequence.¹³The target DNA sequence must be both complementary to the sgRNA and also contain a “protospacer-adjacent motif” (PAM) at the 3′-end of the complementary region in order for the system to function.¹⁴The requirement for a PAM sequence limits the use of Cas9 technology, since not all desired targeted sequences include a PAM sequence at the 3′-end and thus cannot efficiently be targeted by wild-type Cas9 proteins.

Provided herein are novel Cas9 variants that exhibit activity on target sequences that do not include the canonical PAM sequence (5′-NGG-3′, where N is any nucleotide) at the 3′-end. Such Cas9 variants are not restricted to target sequences that include the canonical PAM sequence at the 3′-end.

Among the known Cas proteins, Streptococcus pyogenes Cas9 has been mostly widely used as a tool for genome engineering.¹⁵This Cas9 protein is a large, multi-domain protein containing two distinct nuclease domains. Point mutations can be introduced into Cas9 to abolish nuclease activity, resulting in a dead Cas9 (dCas9) that still retains its ability to bind DNA in a sgRNA-programmed manner.¹⁶In principle, such Cas9 variants, when fused to another protein or domain, can target that protein to virtually any DNA sequence simply by co-expression with an appropriate sgRNA. Thus, this disclosure also contemplates fusion proteins comprising such Cas9 variants and a DNA modifying domain (e.g., a deaminase, a nuclease, a nickase, a recombinase, a methyltransferase, a methylase, an acetylase, an acetyltransferase, a transcriptional activator, or a transcriptional repressor domain), as well as the use of such fusion proteins in correcting mutations in a genome (e.g., the genome of a human subject) that are associated with disease, or generating mutations in a genome (e.g., the human genome) to decrease or prevent expression of a gene.

In some embodiments, any of the Cas9 proteins provided herein may be fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a target DNA. In some embodiments, the enzymatic activity is nuclease activity, methyltransferase activity, demethylase activity, DNA repair activity, DNA damage activity, deamination activity, dismutase activity, alkylation activity, depurination activity, oxidation activity, pyrimidine dimer forming activity, integrase activity, transposase activity, recombinase activity, polymerase activity, ligase activity, helicase activity, photolyase activity or glycosylase activity. In some cases, the enzymatic activity is nuclease activity. In some cases, the nuclease activity introduces a double strand break in the target DNA. In some cases, the enzymatic activity modifies a target polypeptide associated with the target DNA. In some cases, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity, deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity or demyristoylation activity. In some cases, the target polypeptide is a histone and the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity or deubiquitinating activity.

In some embodiments, any of the Cas9 proteins provided herein may be fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a polypeptide associated with DNA (e.g. a histone). In some embodiments, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity (i.e., ubiquitination activity), deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity, demyristoylation activity glycosylation activity (e.g., from O-GlcNAc transferase) or deglycosylation activity. The enzymatic activities listed herein catalyze covalent modifications to proteins. Such modifications are known in the art to alter the stability or activity of the target protein (e.g., phosphorylation due to kinase activity can stimulate or silence protein activity depending on the target protein). Of particular interest as protein targets are histones. Histone proteins are known in the art to bind DNA and form complexes known as nucleosomes. Histones can be modified (e.g., by methylation, acetylation, ubuitination, phosphorylation) to elicit structural changes in the surrounding DNA, thus controlling the accessibility of potentially large portions of DNA to interacting factors such as transcription factors, polymerases and the like. A single histone can be modified in many different ways and in many different combinations (e.g., trimethylation of lysine 27 of histone 3, H3K27, is associated with DNA regions of repressed transcription while trimethylation of lysine 4 of histone 3, H3K4, is associated with DNA regions of active transcription). Thus, a site-directed modifying polypeptide with histone-modifying activity finds use in the site specific control of DNA structure and can be used to alter the histone modification pattern in a selected region of target DNA. Such methods find use in both research and clinical applications.

In some embodiments, the deaminase domain catalyzes the removal of an amine group from a molecule. In further embodiments, cytidine deaminase domains deaminate cytosine to yield uracil. In other embodiments, the nuclease domain has enzymatic activity and may cleave phosphodiester bonds between the nucleotide subunits of nucleic acids. In some embodiments, recombinase domains, which recombine specific sequences of DNA, may be used to manipulate the structure of genomes and to control gene expression. In further embodiments, methylase domains may be utilized to methylate their respective substrates, while acetylase domains may be used to acetylate their respective substrates. In other embodiments, acetyltransferase domains may be used to transfer an acetyl group. Examples of acetyltransferase molecules include, but are not limited to, histone acetyltransferases (e.g., CBP histone acetyltransferase), choline acetyltransferase, chloramphenicol acetytransferase, serotonic N-acetyltransferase, NatA acetyltransferase, and NatB acetyltransferase. The disclosure also contemplates transcriptional activator and transcriptional repressor domains. Transcriptional activator domains are regions of a transcription factor which may activate transcription from a promoter through an interaction or multiple interactions with a DNA binding domain, general transcription factors, and RNA polymerase. Transcriptional repressor domains are regions of a transcription factor which may repress transcription from a protomer through an interaction or multiple interactions with a DNA binding domain, general transcription factors, and RNA polymerase.

The potential of the Cas9 system for genome engineering is immense. Its unique ability to bring proteins to specific sites in a genome programmed by the sgRNA can be developed into a variety of site-specific genome engineering tools beyond nucleases, including transcriptional activators, transcriptional repressors, histone-modifying proteins, integrases, deaminases, and recombinases.¹¹Some of these potential applications have recently been implemented through dCas9 fusions with transcriptional activators to afford RNA-guided transcriptional activators,^17,18transcriptional repressors,^16,19,20and chromatin modification enzymes.²¹Simple co-expression of these fusions with a variety of sgRNAs results in specific expression of the target genes. These seminal studies have paved the way for the design and construction of readily programmable sequence-specific effectors for the precise manipulation of genomes.

Some aspects of this disclosure provide strategies, systems, proteins, nucleic acids, compositions, cells, reagents, methods, and kits that are useful for the targeted binding, editing, and/or cleaving of nucleic acids, including editing a single site within a subject's genome, e.g., a human subject's genome. In some embodiments, recombinant Cas9 proteins are provided that comprise at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, or at least ten mutations as compared to a naturally occurring Cas9 protein, and that exhibit activity on target sequences that do not include the canonical PAM (5′-NGG-3′, where N is any nucleotide) at the 3′-end. Examples of such Cas9 protein mutations are given in Tables 3, 5, 8, and 9. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzymatic domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid binding, editing, and/or cleaving are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid binding, editing, and/or cleaving proteins, e.g., fusion proteins of Cas9 variants and nucleic acid editing enzymes or domains, are provided.

Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences set forth in SEQ ID NOs: 9-262, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of S. pyogenes Cas9 having the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the recombinant Cas9 protein comprises a RuvC and an HNH domain. In some embodiments, the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

Other aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences set forth in SEQ ID NOs: 10-262, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOS: 10-262; and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises a RuvC and an HNH domain. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in in SEQ ID NOs: 10-262.

It should be appreciated that any of the amino acid mutations described herein, (e.g., A262T) from a first amino acid residue (e.g., A) to a second amino acid residue (e.g., T) may also include mutations from the first amino acid residue to an amino acid residue that is similar to (e.g., conserved) the second amino acid residue. For example, a mutation of an alanine to a threonine (e.g., a A262T mutation) may also be a mutation from an alanine to an amino acid that is similar in size and chemical properties to a threonine, for example, serine. Additional similar amino acid pairs include, but are not limited to, the following: phenylalanine and tyrosine; asparagine and glutamine; methionine and cysteine; aspartic acid and glutamic acid; and arginine and lysine. The skilled artisan would recognize that such conservative amino acid substitutions will likely have minor effects on protein structure and are likely to be well tolerated without compromising function. In some embodiments, any of the amino acid mutations provided herein from one amino acid to a threonine may be an amino acid mutation to a serine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to an arginine may be an amino acid mutation to a lysine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to an isoleucine may be an amino acid mutation to an alanine, valine, methionine, or leucine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to a lysine may be an amino acid mutation to an arginine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to an aspartic acid may be an amino acid mutation to a glutamic acid or asparagine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to a valine may be an amino acid mutation to an alanine, isoleucine, methionine, or leucine. In some embodiments, any of the amino acid mutations provided herein from one amino acid to a glycine may be an amino acid mutation to an alanine. It should be appreciated, however, that additional conserved amino acid residues would be recognized by the skilled artisan and any of the amino acid mutations to other conserved amino acid residues are also within the scope of this disclosure.

In some embodiments, the Cas9 protein is a Cas9 domain of a fusion protein. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In some embodiments, the mutation is X1219A, X1219I, X1219M, or X1219L.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the mutation is E1219A, E1219I, E1219M or E1219L.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the mutation is E480R.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the mutation is E543N.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X480K, X543D, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543D, E1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

The HNH nuclease domain of Cas9 functions to cleave the DNA strand complementary to the guide RNA (gRNA). Its active site consists of a ββα-metal fold, and its histidine 840 activates a water molecule to attack the scissile phosphate, which is more electrophilic due to coordination with a magnesium ion, resulting in cleavage of the 3′-5′ phosphate bond. In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

The RuvC domain of Cas9 cleaves the non-target DNA strand. It is encoded by sequentially disparate sites which interact in the tertiary structure to form the RuvC cleavage domain and consists of an RNase H fold structure. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

In some embodiments, the Cas9 protein comprises one or more mutations that affects (e.g., inhibits) the ability of Cas9 to cleave one or both strands of a DNA duplex. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10X₁and/or a H840X₂mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X1 is any amino acid except for D, and X₂is any amino acid except for H. In some embodiments, the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the Cas9 protein of the present disclosure exhibits activity, for example, increased binding, on a target sequence that does not include the canonical PAM sequence (5′-NGG-3′) at its 3′-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not comprise the canonical PAM sequence (5′-NGG-3′) at its 3′ end as compared to Streptococcus pyogenes Cas9 as provided in SEQ ID NO: 9. In some embodiments, the Streptococcus pyogenes Cas9 comprises a RuvC and an HNH domain. In other embodiments, the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9

As one example, the Cas9 protein may exhibit increased binding to the target sequence, may exhibit increased nuclease activity at the target sequence, or may exhibit an increase in other activities, depending on whether the Cas 9 protein is fused to an additional domain, such as an enzyme that has enzymatic activity. In some embodiments, the enzymatic activity modifies a target DNA. In some embodiments, the enzymatic activity is nuclease activity, methyltransferase activity, demethylase activity, DNA repair activity, DNA damage activity, deamination activity, dismutase activity, alkylation activity, depurination activity, oxidation activity, pyrimidine dimer forming activity, integrase activity, transposase activity, recombinase activity, polymerase activity, ligase activity, helicase activity, photolyase activity or glycosylase activity. In some cases, the enzymatic activity is nuclease activity. In some cases, the nuclease activity introduces a double strand break in the target DNA. In some cases, the enzymatic activity modifies a target polypeptide associated with the target DNA. In some cases, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity, deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity or demyristoylation activity. In some cases, the target polypeptide is a histone and the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity or deubiquitinating activity.

In some embodiments, any of the Cas9 protein is fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a polypeptide associated with DNA (e.g. a histone). In some embodiments, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity (i.e., ubiquitination activity), deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity, demyristoylation activity glycosylation activity (e.g., from O-GlcNAc transferase) or deglycosylation activity. The enzymatic activities listed herein catalyze covalent modifications to proteins. Such modifications are known in the art to alter the stability or activity of the target protein (e.g., phosphorylation due to kinase activity can stimulate or silence protein activity depending on the target protein). Of particular interest as protein targets are histones. Histone proteins are known in the art to bind DNA and form complexes known as nucleosomes. Histones can be modified (e.g., by methylation, acetylation, ubuitination, phosphorylation) to elicit structural changes in the surrounding DNA, thus controlling the accessibility of potentially large portions of DNA to interacting factors such as transcription factors, polymerases and the like. A single histone can be modified in many different ways and in many different combinations (e.g., trimethylation of lysine 27 of histone 3, H3K27, is associated with DNA regions of repressed transcription while trimethylation of lysine 4 of histone 3, H3K4, is associated with DNA regions of active transcription). Thus, a site-directed modifying polypeptide with histone-modifying activity finds use in the site specific control of DNA structure and can be used to alter the histone modification pattern in a selected region of target DNA. Such methods find use in both research and clinical applications.

In some embodiments, the Cas9 protein exhibits activity on a target sequence having a 3′ end that is not directly adjacent to, or does not have the canonical PAM sequence (5′-NGG-3′), that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

In some embodiments, the 3′-end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, CAA CAC, GAT, TAA, ACG, CGA, or CGT sequence.

In some embodiments, the Cas9 protein activity is measured by a nuclease assay or a nucleic acid binding assay, which are known in the art and would be apparent to the skilled artisan. As provided herein, the Cas9 protein may be fused to one or more domains that confer an activity to the protein, such as a nucleic acid editing activity (e.g., deaminase activity or transcriptional activation activity), which may be measured (e.g., by a deaminase assay or transcriptional activation assay). In some embodiments, the Cas9 protein is fused to a deaminase domain and its activity may be measured using a deaminase assay. In some embodiments, the Cas9 protein is fused to a transcriptional activation domain and its activity may be measured using a transcriptional activation assay, for example, reporter activation assay where the reporter, e.g., GFP or luciferase, among others, is expressed in response to Cas9 binding to a target sequence.

In some embodiments, the amino acid sequence of the Cas9 protein comprises any of the mutations provided herein. For example, in some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In other embodiments, the mutations may be A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises any of the mutations provided herein. For example, in some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In other embodiments, the mutations may be A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation or an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X480K mutation or an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X543D mutation or a E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 comprises the mutations X480K, X543D, and X1219V; or the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V; or the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P; or the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K, or mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K; or the mutations S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V; or the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the RuvC domain is identical to the amino acid sequence of any of the RuvC domains of SEQ ID NOs: 9-262.

In some embodiments, the Cas9 protein comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10X₁and/or a H840X₂mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X₁is any amino acid except for D, and wherein X₂is any amino acid except for H. In some embodiments, the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOS: 10-262.

Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein as provided herein that is fused to a second protein, thus forming a fusion protein. In some embodiments, the second protein is fused to the N-terminus of the Cas9 protein. In some embodiments, the second protein is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 domain and the effector domain are fused via a linker. The linker may be as simple as a covalent bond, or it may be a polymeric linker many atoms in length. In certain embodiments, the linker is a polypeptide or based on amino acids. In other embodiments, the linker is not peptide-like. In certain embodiments, the linker is a covalent bond (e.g., a carbon-carbon bond, disulfide bond, carbon-heteroatom bond, etc.). In certain embodiments, the linker is a carbon-nitrogen bond of an amide linkage. In certain embodiments, the linker is a cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic or heteroaliphatic linker. In certain embodiments, the linker is polymeric (e.g., polyethylene, polyethylene glycol, polyamide, polyester, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminoalkanoic acid. In certain embodiments, the linker comprises an aminoalkanoic acid (e.g., glycine, ethanoic acid, alanine, beta-alanine, 3-aminopropanoic acid, 4-aminobutanoic acid, 5-pentanoic acid, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminohexanoic acid (Ahx). In certain embodiments, the linker is based on a carbocyclic moiety (e.g., cyclopentane, cyclohexane). In other embodiments, the linker comprises a polyethylene glycol moiety (PEG). In other embodiments, the linker comprises amino acids. In certain embodiments, the linker comprises a peptide. In certain embodiments, the linker comprises an aryl or heteroaryl moiety. In certain embodiments, the linker is based on a phenyl ring. The linker may included functionalized moieties to facilitate attachment of a nucleophile (e.g., thiol, amino) from the peptide to the linker. Any electrophile may be used as part of the linker. Exemplary electrophiles include, but are not limited to, activated esters, activated amides, Michael acceptors, alkyl halides, aryl halides, acyl halides, and isothiocyanates.

In some embodiments, the linker comprises a chemical group or molecule linking two molecules or moieties, e.g., two domains of a fusion protein, such as, for example, a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain). In some embodiments, the linker comprises one or more amino acid residues. For example, the linker may comprise at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 25, 30, 35, 40, 45, 50, or more amino acid residues. In some embodiments, the linker is 3, 9, 16, or 21 amino acids in length. In some embodiments, the linker comprises a (GGGGS)_n(SEQ ID NO: 5), a (G)_n(SEQ ID NO: 5087), an (EAAAK)_n(SEQ ID NO: 6), a (GGS)_n(SEQ ID NO: 5088), an SGSETPGTSESATPES (SEQ ID NO: 7) (also referred to as XTEN), or an (XP)_n(SEQ ID NO: 5089) motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, wherein the linker comprises a (GGS)₃(SEQ ID NO: 5088) motif or a SGSETPGTSESATPES (SEQ ID NO: 7) (XTEN) motif.

In some embodiments, the effector domain comprises an enzymatic domain. In some embodiments, the effector domain comprises a nuclease, a nickase, a recombinase, a deaminase, a methyltransferase, a methylase, an acetylase, an acetyltransferase, a transcriptional activator, or a transcriptional repressor domain, which may have nuclease activity, nickase activity, recombinase activity, deaminase activity, methyltransferase activity, methylase activity, acetylase activity, acetyltransferase activity transcriptional activation activity or transcriptional repression activity, respectively. In some embodiments, the effector domain is a effector domain. In some embodiments, the effector domain is a deaminase domain. In some embodiments, the deaminase is a cytosine deaminase or a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC1 deaminase. In some embodiments, the deaminase is an APOBEC2 deaminase. In some embodiments, the deaminase is an APOBEC3 deaminase. In some embodiments, the deaminase is an APOBEC3A deaminase. In some embodiments, the deaminase is an APOBEC3D deaminase. In some embodiments, the deaminase is an APOBEC3E deaminase. In some embodiments, the deaminase is an APOBEC3F deaminase. In some embodiments, the deaminase is an APOBEC3G deaminase. In some embodiments, the deaminase is an APOBEC3H deaminase. In some embodiments, the deaminase is an APOBEC4 deaminase. In some embodiments, the deaminase is an activation-induced deaminase (AID). In some embodiments, the effector domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the deaminase domain of any one of SEQ ID NOs: 263-281. In some embodiments, the deaminase is a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC1 family deaminase. In some embodiments, the deaminase is an activation-induced cytidine deaminase (AID). In some embodiments, the deaminase is an ACF1/ASE deaminase. In some embodiments, the deaminase is an adenosine deaminase. In some embodiments, the deaminase is an ADAT family deaminase.

Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein fused to a effector domain, e.g., a deaminase, and a uracil glycosylase inhibitor (UGI). Some aspects of this disclosure are based on the recognition that such fusion proteins may exhibit an increased nucleic acid editing efficiency as compared to fusion proteins not comprising an UGI domain. Domains such as the deaminase domains and UGI domains have been described and are within the scope of this disclosure. For example domains such as deaminase domains and UGI domains have been described in Provisional Application Nos. 62/245,828, filed Oct. 23, 2015, 62/279,346 filed Jan. 15, 2016, 62/311,763 filed Mar. 22, 2016, 62/322,178 filed Apr. 13, 2016, 62/357,352 filed Jun. 30, 2016, 62/370,700 filed Aug. 3, 2016, 62/398,490 filed Sep. 22, 2016, and 62/408,686 filed Oct. 14, 2016; the entire contents of each is incorporated by reference herein. It should be appreciated that the deaminase domains and UGI domains described in the foregoing references are within the scope of this disclosure and may be fused with any of the Cas9 proteins provided herein.

In some embodiments, the effector domain of the fusion protein is a nuclease domain. In some embodiments, the nuclease domain is a FokI DNA cleavage domain. In some embodiments, the fusion protein dimerizes. In certain embodiments, the dimer of the fusion protein is active. For example, two Fok1 DNA cleavage domains may dimerize to cleave a nucleic acid.

In some embodiments, the Cas9 protein is fused to a second Cas9 protein. In some embodiments, the second Cas9 protein is the Cas9 protein of any one of claims 1-345. In some embodiments, the second Cas9 protein is fused to the N-terminus of the fusion protein. In some embodiments, the second Cas9 protein is fused to the C-terminus of the fusion protein. In some embodiments, the Cas9 protein and the second Cas9 protein are fused via a second linker. In some embodiments, the second linker comprises a (GGGGS), (SEQ ID NO: 5), a (G), (SEQ ID NO: 5087), an (EAAAK), (SEQ ID NO: 6), a (GGS), (SEQ ID NO: 5088), an SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP), (SEQ ID NO: 5089) motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, the second linker comprises a (GGS) 3 (SEQ ID NO: 5088) motif.

Some aspects of this disclosure provide complexes comprising a Cas9 protein, or a Cas9 fusion protein as provided herein, and a guide RNA bound to the Cas9 protein, or the Cas9 fusion protein.

In some embodiments, the target sequence is a DNA sequence. In some embodiments, the target sequence is a sequence in the genome of a mammal. In some embodiments, the target sequence is a sequence in the genome of a human. In some embodiments, the 3′-end of the target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′).

Some aspects of this disclosure provide methods of using the Cas9 proteins, fusion proteins, or complexes provided herein. For example, some aspects of this disclosure provide methods comprising contacting a DNA molecule (a) with a Cas9 protein or a fusion protein as provided herein and a guide RNA, wherein the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence; or (b) with a Cas9 protein, a Cas9 fusion protein, or a Cas9 protein or fusion protein complex with a gRNA as provided herein. In some embodiments, the 3′-end of the target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′). In some embodiments, the 3′-end of the target sequence is immediately adjacent to an AGC, GAG, TTT, GTG, or CAA sequence. In some embodiments, the target DNA sequence comprises a sequence associated with a disease or disorder. In some embodiments, the target DNA sequence comprises a point mutation associated with a disease or disorder. In some embodiments, the activity of the Cas9 protein, the Cas9 fusion protein, or the complex results in correction of the point mutation. In some embodiments, the step of contacting is performed in vivo in a subject.

Some aspects of this disclosure provide kits comprising a nucleic acid construct, comprising (a) a nucleotide sequence encoding a Cas9 protein or a Cas9 fusion protein as provided herein; and (b) a heterologous promoter that drives expression of the sequence of (a). In some embodiments, the kit further comprises an expression construct encoding a guide RNA backbone, wherein the construct comprises a cloning site positioned to allow the cloning of a nucleic acid sequence identical or complementary to a target sequence into the guide RNA backbone.

Some aspects of this disclosure provide polynucleotides encoding any of the Cas9 proteins, Cas9 fusion proteins, or guide RNA bound to the Cas9 protein or Cas9 fusion protein provided herein. Some aspects of this disclosure provide vectors comprising such polynucleotides. In some embodiments, the vector comprises a heterologous promoter driving expression of the polynucleotide.

Some aspects of this disclosure provide cells comprising any of the Cas9 proteins, fusion proteins, nucleic acid molecules, and/or a vectors as provided herein.

The summary above is meant to illustrate, in a non-limiting manner, some of the embodiments, advantages, features, and uses of the technology disclosed herein. Other embodiments, advantages, features, and uses of the technology disclosed herein will be apparent from the Detailed Description, the Drawings, the Examples, and the Claims.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the activity of wild-type Streptococcus pyogenes Cas9 on canonical PAM libraries and non-canonical PAM libraries.

FIG. 2 shows the activity of exemplary evolved Cas9 clones on a PAM library after directed evolution.

FIG. 3 shows a comparison of wild-type and evolved Cas9 in a mammalian GFP activation assay.

FIGS. 4A to 4B show the binding activity of Cas9 (pJH306) and evolved Cas9 proteins with an 5′-NGG-3′ PAM sequence using GFP as a readout. On 5′-NGG-3′ PAMs, many of the evolved Cas9 proteins showed increased Cas9 binding activity relative to wild-type Cas9 based on an increase in GFP fluorescence signal. FIG. 4A is a graph representing Cas9 binding activity as a function of % cells above the background fluorescence. FIG. 4B is a graph showing Cas9 binding activity as a function of mean fluorescence. Cas9 proteins used in these experiments were dCas9 proteins fused to a VPR transcriptional activator.

FIGS. 5A to 5B show the binding activity of wild type dCas9-VPR (pJH306) and evolved dCas9-VPR proteins with an NNN PAM sequence using GFP as a readout. On a library of NNN PAMs, many of the evolved Cas9 proteins showed increased Cas9 binding activity relative to wild-type Cas9 based on an increase in GFP fluorescence signal. FIG. 5A is a graph representing Cas9 binding activity as a function of % cells above background fluorescence. FIG. 5B is a graph showing Cas9 binding activity as a function of mean fluorescence. Cas9 proteins used in these experiments were dCas9 proteins fused to VPR.

FIG. 6 shows dCas9-VPR on all 64 PAM sequences as demonstrated by mean fluorescence on transfected cells gated by iRFP fluorescence. WT dCas9-VPR is pJH306.

FIG. 7 shows in vitro cutting assay. On the gel, WT is wild-type Cas9 (SEQ ID NO: 9), and 1 is Cas9 (SEQ ID NO: 9) with the E1219V mutation.

FIG. 8 shows a Cas9 fusion protein that can be used to modulate PAM specificity. One possible configuration for a linked Cas9-dCas9 system that could be used for increasing Cas9 targeting to non-canonical PAMs is shown. dCas9 binding to 5′-NGG-3′ or another PAM could localize Cas9 to an area close to target 2. This localization could help Cas9 cut a previously inaccessible PAM.

FIGS. 9A to 9B show dCas9-VPR binding activity on the NNNNN PAM Library. FIG. 9A is a graph representing dCas9-VPR binding activity on the NNNNN PAM library as a function of the % cells above background fluorescence. FIG. 9B is a graph representing dCas9-VPR binding activity on the NNNNN PAM library as a function of mean fluorescence.

FIG. 10 shows Cas9 cutting activity using % of cells with GFP loss as a readout. Cas9 proteins were tested with two sgRNAs, which either targeted the canonical 5′-NGG-3′ PAM or a GAT PAM within a GFP gene.

FIG. 11 illustrates double-stranded DNA substrate bound by Cas9:DNA editing enzyme:sgRNA complexes. The DNA editing enzyme may be, without limitation, a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, or acetyltransferase.

FIG. 12 shows the results of the PAM depletion assay. pJH760 was tested in the PAM depletion assay on four new targets: re2, VEGF, CLTA, and CCR5D.

FIG. 13 shows GFP cutting in mammalian cells.

FIG. 14 shows the results of a PAM depletion assay to test pJH760 (xCas9 v1.0) on the re2 target.

FIG. 15 shows the results of a PAM depletion assay to test pJH760 (xCas9 v1.0) on the VEGF target.

FIG. 16 shows the results of a PAM depletion assay to test pJH760 (xCas9 v1.0) on the CLTA target.

FIG. 17 shows the results of a PAM depletion assay to test pJH760 (xCas9 v1.0) on the CCR5D target.

FIG. 18 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the re2 target.

FIG. 19 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the VEGF target.

FIG. 20 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the CLTA target.

DEFINITIONS

As used herein and in the claims, the singular forms “a,” “an,” and “the” include the singular and the plural reference unless the context clearly indicates otherwise. Thus, for example, a reference to “an agent” includes a single agent and a plurality of such agents.

The term “Cas9” or “Cas9 nuclease” refers to an RNA-guided nuclease comprising a Cas9 protein, or a fragment thereof (e.g., a protein comprising an active or inactive DNA cleavage domain of Cas9, and/or the gRNA binding domain of Cas9). A Cas9 nuclease is also referred to sometimes as a casn1 nuclease or a CRISPR (clustered regularly interspaced short palindromic repeat)-associated nuclease. CRISPR is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and a Cas9 protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently, Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed 3′-5′ exonucleolytically. In nature, DNA-binding and cleavage typically requires protein and both RNAs. However, single guide RNAs (“sgRNA”, or simply “gNRA”) can be engineered so as to incorporate aspects of both the crRNA and tracrRNA into a single RNA species. See, e.g., Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J. A., Charpentier E. Science 337:816-821 (2012), the entire contents of which are hereby incorporated by reference. Cas9 recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus non-self. Cas9 nuclease sequences and structures are well known to those of skill in the art (see, e.g., “Complete genome sequence of an MI strain of Streptococcus pyogenes.” Ferretti et al., J. J., McShan W. M., Ajdic D. J., Savic D. J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A. N., Kenton S., Lai H. S., Lin S. P., Qian Y., Jia H. G., Najar F. Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S. W., Roc B. A., McLaughlin R. E., Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663 (2001); “CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.” Deltcheva E., Chylinski K., Sharma C. M., Gonzales K., Chao Y., Pirzada Z. A., Eckert M. R., Vogel J., Charpentier E., Nature 471:602-607 (2011); and “A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.” Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J. A., Charpentier E. Science 337:816-821 (2012), the entire contents of each of which are incorporated herein by reference). Cas9 orthologs have been described in various species, including, but not limited to, S. pyogenes and S. thermophilus. Additional suitable Cas9 nucleases and sequences will be apparent to those of skill in the art based on this disclosure, and such Cas9 nucleases and sequences include Cas9 sequences from the organisms and loci disclosed in Chylinski, Rhun, and Charpentier, “The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems” (2013) RNA Biology 10:5, 726-737; the entire contents of which are incorporated herein by reference. In some embodiments, a Cas9 nuclease has an inactive (e.g., an inactivated) DNA cleavage domain.

A nuclease-inactivated Cas9 protein may interchangeably be referred to as a “dCas9” protein (for nuclease-“dead” Cas9). Methods for generating a Cas9 having an inactive DNA cleavage domain are known (See, e.g., Jinek et al., Science. 337:816-821 (2012); Qi et al., “Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression” (2013) Cell. 28; 152 (5): 1173-83, the entire contents of each of which are incorporated herein by reference). For example, the DNA cleavage domain of Cas9 is known to include two subdomains, the HNH nuclease subdomain and the RuvC1 subdomain. The HNH subdomain cleaves the strand complementary to the gRNA, whereas the RuvC1 subdomain cleaves the non-complementary strand. Mutations within these subdomains can silence the nuclease activity of Cas9. For example, the mutations D10A and H840A completely inactivate the nuclease activity of S. pyogenes Cas9 (Jinek et al., Science. 337:816-821 (2012); Qi et al., Cell. 28; 152 (5): 1173-83 (2013).

In some embodiments, proteins comprising fragments of Cas9 are provided. For example, in some embodiments, a protein comprises one of two Cas9 domains: (1) the gRNA binding domain of Cas9; or (2) the DNA cleavage domain of Cas9. In some embodiments, proteins comprising Cas9 or fragments thereof are referred to as “Cas9 variants.” A Cas9 variant shares homology to Cas9. For example a Cas9 variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to wild type Cas9. In some embodiments, the Cas9 variant comprises a fragment of Cas9 (e.g., a gRNA binding domain or a DNA-cleavage domain), such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type Cas9. In some embodiments, wild type Cas9 corresponds to Cas9 from Streptococcus pyogenes (NCBI Reference Sequence: NC_017053.1, SEQ ID NO:1 (nucleotide); SEQ ID NO:2 (amino acid)).

(SEQ ID NO: 1)

ATGGATAAGAAATACTCAATAGGCTTAGATATCGGCACAAATAGCGTCGGATGGGCGGTGATCACTGATGATTATAA

GGTTCCGTCTAAAAAGTTCAAGGTTCTGGGAAATACAGACCGCCACAGTATCAAAAAAAATCTTATAGGGGCTCTTT

TATTTGGCAGTGGAGAGACAGCGGAAGCGACTCGTCTCAAACGGACAGCTCGTAGAAGGTATACACGTCGGAAGAAT

CGTATTTGTTATCTACAGGAGATTTTTTCAAATGAGATGGCGAAAGTAGATGATAGTTTCTTTCATCGACTTGAAGA

GTCTTTTTTGGTGGAAGAAGACAAGAAGCATGAACGTCATCCTATTTTTGGAAATATAGTAGATGAAGTTGCTTATC

ATGAGAAATATCCAACTATCTATCATCTGCGAAAAAAATTGGCAGATTCTACTGATAAAGCGGATTTGCGCTTAATC

TATTTGGCCTTAGCGCATATGATTAAGTTTCGTGGTCATTTTTTGATTGAGGGAGATTTAAATCCTGATAATAGTGA

TGTGGACAAACTATTTATCCAGTTGGTACAAATCTACAATCAATTATTTGAAGAAAACCCTATTAACGCAAGTAGAG

TAGATGCTAAAGCGATTCTTTCTGCACGATTGAGTAAATCAAGACGATTAGAAAATCTCATTGCTCAGCTCCCCGGT

GAGAAGAGAAATGGCTTGTTTGGGAATCTCATTGCTTTGTCATTGGGATTGACCCCTAATTTTAAATCAAATTTTGA

TTTGGCAGAAGATGCTAAATTACAGCTTTCAAAAGATACTTACGATGATGATTTAGATAATTTATTGGCGCAAATTG

GAGATCAATATGCTGATTTGTTTTTGGCAGCTAAGAATTTATCAGATGCTATTTTACTTTCAGATATCCTAAGAGTA

AATAGTGAAATAACTAAGGCTCCCCTATCAGCTTCAATGATTAAGCGCTACGATGAACATCATCAAGACTTGACTCT

TTTAAAAGCTTTAGTTCGACAACAACTTCCAGAAAAGTATAAAGAAATCTTTTTTGATCAATCAAAAAACGGATATG

CAGGTTATATTGATGGGGGAGCTAGCCAAGAAGAATTTTATAAATTTATCAAACCAATTTTAGAAAAAATGGATGGT

ACTGAGGAATTATTGGTGAAACTAAATCGTGAAGATTTGCTGCGCAAGCAACGGACCTTTGACAACGGCTCTATTCC

CCATCAAATTCACTTGGGTGAGCTGCATGCTATTTTGAGAAGACAAGAAGACTTTTATCCATTTTTAAAAGACAATC

GTGAGAAGATTGAAAAAATCTTGACTTTTCGAATTCCTTATTATGTTGGTCCATTGGCGCGTGGCAATAGTCGTTTT

GCATGGATGACTCGGAAGTCTGAAGAAACAATTACCCCATGGAATTTTGAAGAAGTTGTCGATAAAGGTGCTTCAGC

TCAATCATTTATTGAACGCATGACAAACTTTGATAAAAATCTTCCAAATGAAAAAGTACTACCAAAACATAGTTTGC

TTTATGAGTATTTTACGGTTTATAACGAATTGACAAAGGTCAAATATGTTACTGAGGGAATGCGAAAACCAGCATTT

CTTTCAGGTGAACAGAAGAAAGCCATTGTTGATTTACTCTTCAAAACAAATCGAAAAGTAACCGTTAAGCAATTAAA

AGAAGATTATTTCAAAAAAATAGAATGTTTTGATAGTGTTGAAATTTCAGGAGTTGAAGATAGATTTAATGCTTCAT

TAGGCGCCTACCATGATTTGCTAAAAATTATTAAAGATAAAGATTTTTTGGATAATGAAGAAAATGAAGATATCTTA

GAGGATATTGTTTTAACATTGACCTTATTTGAAGATAGGGGGATGATTGAGGAAAGACTTAAAACATATGCTCACCT

CTTTGATGATAAGGTGATGAAACAGCTTAAACGTCGCCGTTATACTGGTTGGGGACGTTTGTCTCGAAAATTGATTA

ATGGTATTAGGGATAAGCAATCTGGCAAAACAATATTAGATTTTTTGAAATCAGATGGTTTTGCCAATCGCAATTTT

ATGCAGCTGATCCATGATGATAGTTTGACATTTAAAGAAGATATTCAAAAAGCACAGGTGTCTGGACAAGGCCATAG

TTTACATGAACAGATTGCTAACTTAGCTGGCAGTCCTGCTATTAAAAAAGGTATTTTACAGACTGTAAAAATTGTTG

ATGAACTGGTCAAAGTAATGGGGCATAAGCCAGAAAATATCGTTATTGAAATGGCACGTGAAAATCAGACAACTCAA

AAGGGCCAGAAAAATTCGCGAGAGCGTATGAAACGAATCGAAGAAGGTATCAAAGAATTAGGAAGTCAGATTCTTAA

AGAGCATCCTGTTGAAAATACTCAATTGCAAAATGAAAAGCTCTATCTCTATTATCTACAAAATGGAAGAGACATGT

ATGTGGACCAAGAATTAGATATTAATCGTTTAAGTGATTATGATGTCGATCACATTGTTCCACAAAGTTTCATTAAA

GACGATTCAATAGACAATAAGGTACTAACGCGTTCTGATAAAAATCGTGGTAAATCGGATAACGTTCCAAGTGAAGA

AGTAGTCAAAAAGATGAAAAACTATTGGAGACAACTTCTAAACGCCAAGTTAATCACTCAACGTAAGTTTGATAATT

TAACGAAAGCTGAACGTGGAGGTTTGAGTGAACTTGATAAAGCTGGTTTTATCAAACGCCAATTGGTTGAAACTCGC

CAAATCACTAAGCATGTGGCACAAATTTTGGATAGTCGCATGAATACTAAATACGATGAAAATGATAAACTTATTCG

AGAGGTTAAAGTGATTACCTTAAAATCTAAATTAGTTTCTGACTTCCGAAAAGATTTCCAATTCTATAAAGTACGTG

AGATTAACAATTACCATCATGCCCATGATGCGTATCTAAATGCCGTCGTTGGAACTGCTTTGATTAAGAAATATCCA

AAACTTGAATCGGAGTTTGTCTATGGTGATTATAAAGTTTATGATGTTCGTAAAATGATTGCTAAGTCTGAGCAAGA

AATAGGCAAAGCAACCGCAAAATATTTCTTTTACTCTAATATCATGAACTTCTTCAAAACAGAAATTACACTTGCAA

ATGGAGAGATTCGCAAACGCCCTCTAATCGAAACTAATGGGGAAACTGGAGAAATTGTCTGGGATAAAGGGCGAGAT

TTTGCCACAGTGCGCAAAGTATTGTCCATGCCCCAAGTCAATATTGTCAAGAAAACAGAAGTACAGACAGGCGGATT

CTCCAAGGAGTCAATTTTACCAAAAAGAAATTCGGACAAGCTTATTGCTCGTAAAAAAGACTGGGATCCAAAAAAAT

ATGGTGGTTTTGATAGTCCAACGGTAGCTTATTCAGTCCTAGTGGTTGCTAAGGTGGAAAAAGGGAAATCGAAGAAG

TTAAAATCCGTTAAAGAGTTACTAGGGATCACAATTATGGAAAGAAGTTCCTTTGAAAAAAATCCGATTGACTTTTT

AGAAGCTAAAGGATATAAGGAAGTTAAAAAAGACTTAATCATTAAACTACCTAAATATAGTCTTTTTGAGTTAGAAA

ACGGTCGTAAACGGATGCTGGCTAGTGCCGGAGAATTACAAAAAGGAAATGAGCTGGCTCTGCCAAGCAAATATGTG

AATTTTTTATATTTAGCTAGTCATTATGAAAAGTTGAAGGGTAGTCCAGAAGATAACGAACAAAAACAATTGTTTGT

GGAGCAGCATAAGCATTATTTAGATGAGATTATTGAGCAAATCAGTGAATTTTCTAAGCGTGTTATTTTAGCAGATG

CCAATTTAGATAAAGTTCTTAGTGCATATAACAAACATAGAGACAAACCAATACGTGAACAAGCAGAAAATATTATT

CATTTATTTACGTTGACGAATCTTGGAGCTCCCGCTGCTTTTAAATATTTTGATACAACAATTGATCGTAAACGATA

TACGTCTACAAAAGAAGTTTTAGATGCCACTCTTATCCATCAATCCATCACTGGTCTTTATGAAACACGCATTGATT

TGAGTCAGCTAGGAGGTGACTGA

(SEQ ID NO: 2)

MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFGSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLADSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQIYNQLFEENPINASRVDAKAILSARLSKSRRLENLIAQLPG

EKRNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGAYHDLLKIIKDKDFLDNEENEDIL

EDIVLTLTLFEDRGMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNF

MQLIHDDSLTFKEDIQKAQVSGQGHSLHEQIANLAGSPAIKKGILOTVKIVDELVKVMGHKPENIVIEMARENQTTQ

KGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFIK

DDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKROLVETR

QITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYP

KLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRD

FATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGEDSPTVAYSVLVVAKVEKGKSKK

LKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYV

NFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENII

HLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

In some embodiments, wild type Cas9 corresponds to, or comprises SEQ ID NO:3 (nucleotide) and/or SEQ ID NO: 4 (amino acid):

(SEQ ID NO: 3)

ATGGATAAAAAGTATTCTATTGGTTTAGACATCGGCACTAATTCCGTTGGATGGGCTGTCATAACCGATGAATACAA

AGTACCTTCAAAGAAATTTAAGGTGTTGGGGAACACAGACCGTCATTCGATTAAAAAGAATCTTATCGGTGCCCTCC

TATTCGATAGTGGCGAAACGGCAGAGGCGACTCGCCTGAAACGAACCGCTCGGAGAAGGTATACACGTCGCAAGAAC

CGAATATGTTACTTACAAGAAATTTTTAGCAATGAGATGGCCAAAGTTGACGATTCTTTCTTTCACCGTTTGGAAGA

GTCCTTCCTTGTCGAAGAGGACAAGAAACATGAACGGCACCCCATCTTTGGAAACATAGTAGATGAGGTGGCATATC

ATGAAAAGTACCCAACGATTTATCACCTCAGAAAAAAGCTAGTTGACTCAACTGATAAAGCGGACCTGAGGTTAATC

TACTTGGCTCTTGCCCATATGATAAAGTTCCGTGGGCACTTTCTCATTGAGGGTGATCTAAATCCGGACAACTCGGA

TGTCGACAAACTGTTCATCCAGTTAGTACAAACCTATAATCAGTTGTTTGAAGAGAACCCTATAAATGCAAGTGGCG

TGGATGCGAAGGCTATTCTTAGCGCCCGCCTCTCTAAATCCCGACGGCTAGAAAACCTGATCGCACAATTACCCGGA

GAGAAGAAAAATGGGTTGTTCGGTAACCTTATAGCGCTCTCACTAGGCCTGACACCAAATTTTAAGTCGAACTTCGA

CTTAGCTGAAGATGCCAAATTGCAGCTTAGTAAGGACACGTACGATGACGATCTCGACAATCTACTGGCACAAATTG

GAGATCAGTATGCGGACTTATTTTTGGCTGCCAAAAACCTTAGCGATGCAATCCTCCTATCTGACATACTGAGAGTT

AATACTGAGATTACCAAGGCGCCGTTATCCGCTTCAATGATCAAAAGGTACGATGAACATCACCAAGACTTGACACT

TCTCAAGGCCCTAGTCCGTCAGCAACTGCCTGAGAAATATAAGGAAATATTCTTTGATCAGTCGAAAAACGGGTACG

CAGGTTATATTGACGGCGGAGCGAGTCAAGAGGAATTCTACAAGTTTATCAAACCCATATTAGAGAAGATGGATGGG

ACGGAAGAGTTGCTTGTAAAACTCAATCGCGAAGATCTACTGCGAAAGCAGCGGACTTTCGACAACGGTAGCATTCC

ACATCAAATCCACTTAGGCGAATTGCATGCTATACTTAGAAGGCAGGAGGATTTTTATCCGTTCCTCAAAGACAATC

GTGAAAAGATTGAGAAAATCCTAACCTTTCGCATACCTTACTATGTGGGACCCCTGGCCCGAGGGAACTCTCGGTTC

GCATGGATGACAAGAAAGTCCGAAGAAACGATTACTCCATGGAATTTTGAGGAAGTTGTCGATAAAGGTGCGTCAGC

TCAATCGTTCATCGAGAGGATGACCAACTTTGACAAGAATTTACCGAACGAAAAAGTATTGCCTAAGCACAGTTTAC

TTTACGAGTATTTCACAGTGTACAATGAACTCACGAAAGTTAAGTATGTCACTGAGGGCATGCGTAAACCCGCCTTT

CTAAGCGGAGAACAGAAGAAAGCAATAGTAGATCTGTTATTCAAGACCAACCGCAAAGTGACAGTTAAGCAATTGAA

AGAGGACTACTTTAAGAAAATTGAATGCTTCGATTCTGTCGAGATCTCCGGGGTAGAAGATCGATTTAATGCGTCAC

TTGGTACGTATCATGACCTCCTAAAGATAATTAAAGATAAGGACTTCCTGGATAACGAAGAGAATGAAGATATCTTA

GAAGATATAGTGTTGACTCTTACCCTCTTTGAAGATCGGGAAATGATTGAGGAAAGACTAAAAACATACGCTCACCT

GTTCGACGATAAGGTTATGAAACAGTTAAAGAGGCGTCGCTATACGGGCTGGGGACGATTGTCGCGGAAACTTATCA

ACGGGATAAGAGACAAGCAAAGTGGTAAAACTATTCTCGATTTTCTAAAGAGCGACGGCTTCGCCAATAGGAACTTT

ATGCAGCTGATCCATGATGACTCTTTAACCTTCAAAGAGGATATACAAAAGGCACAGGTTTCCGGACAAGGGGACTC

ATTGCACGAACATATTGCGAATCTTGCTGGTTCGCCAGCCATCAAAAAGGGCATACTCCAGACAGTCAAAGTAGTGG

ATGAGCTAGTTAAGGTCATGGGACGTCACAAACCGGAAAACATTGTAATCGAGATGGCACGCGAAAATCAAACGACT

CAGAAGGGGCAAAAAAACAGTCGAGAGCGGATGAAGAGAATAGAAGAGGGTATTAAAGAACTGGGCAGCCAGATCTT

AAAGGAGCATCCTGTGGAAAATACCCAATTGCAGAACGAGAAACTTTACCTCTATTACCTACAAAATGGAAGGGACA

TGTATGTTGATCAGGAACTGGACATAAACCGTTTATCTGATTACGACGTCGATCACATTGTACCCCAATCCTTTTTG

AAGGACGATTCAATCGACAATAAAGTGCTTACACGCTCGGATAAGAACCGAGGGAAAAGTGACAATGTTCCAAGCGA

GGAAGTCGTAAAGAAAATGAAGAACTATTGGCGGCAGCTCCTAAATGCGAAACTGATAACGCAAAGAAAGTTCGATA

ACTTAACTAAAGCTGAGAGGGGTGGCTTGTCTGAACTTGACAAGGCCGGATTTATTAAACGTCAGCTCGTGGAAACC

CGCCAAATCACAAAGCATGTTGCACAGATACTAGATTCCCGAATGAATACGAAATACGACGAGAACGATAAGCTGAT

TCGGGAAGTCAAAGTAATCACTTTAAAGTCAAAATTGGTGTCGGACTTCAGAAAGGATTTTCAATTCTATAAAGTTA

GGGAGATAAATAACTACCACCATGCGCACGACGCTTATCITAATGCCGTCGTAGGGACCGCACTCATTAAGAAATAC

CCGAAGCTAGAAAGTGAGTTTGTGTATGGTGATTACAAAGTTTATGACGTCCGTAAGATGATCGCGAAAAGCGAACA

GGAGATAGGCAAGGCTACAGCCAAATACTTCTTTTATTCTAACATTATGAATTTCTTTAAGACGGAAATCACTCTGG

CAAACGGAGAGATACGCAAACGACCTTTAATTGAAACCAATGGGGAGACAGGTGAAATCGTATGGGATAAGGGCCGG

GACTTCGCGACGGTGAGAAAAGTTTTGTCCATGCCCCAAGTCAACATAGTAAAGAAAACTGAGGTGCAGACCGGAGG

GTTTTCAAAGGAATCGATTCTTCCAAAAAGGAATAGTGATAAGCTCATCGCTCGTAAAAAGGACTGGGACCCGAAAA

AGTACGGTGGCTTCGATAGCCCTACAGTTGCCTATTCTGTCCTAGTAGTGGCAAAAGTTGAGAAGGGAAAATCCAAG

AAACTGAAGTCAGTCAAAGAATTATTGGGGATAACGATTATGGAGCGCTCGTCTTTTGAAAAGAACCCCATCGACTT

CCTTGAGGCGAAAGGTTACAAGGAAGTAAAAAAGGATCTCATAATTAAACTACCAAAGTATAGTCTGTTTGAGTTAG

AAAATGGCCGAAAACGGATGTTGGCTAGCGCCGGAGAGCTTCAAAAGGGGAACGAACTCGCACTACCGTCTAAATAC

GTGAATTTCCTGTATTTAGCGTCCCATTACGAGAAGTTGAAAGGTTCACCTGAAGATAACGAACAGAAGCAACTTTT

TGTTGAGCAGCACAAACATTATCTCGACGAAATCATAGAGCAAATTTCGGAATTCAGTAAGAGAGTCATCCTAGCTG

ATGCCAATCTGGACAAAGTATTAAGCGCATACAACAAGCACAGGGATAAACCCATACGTGAGCAGGCGGAAAATATT

ATCCATTTGTTTACTCTTACCAACCTCGGCGCTCCAGCCGCATTCAAGTATTTTGACACAACGATAGATCGCAAACG

ATACACTTCTACCAAGGAGGTGCTAGACGCGACACTGATTCACCAATCCATCACGGGATTATATGAAACTCGGATAG

ATTTGTCACAGCTTGGGGGTGACGGATCCCCCAAGAAGAAGAGGAAAGTCTCGAGCGACTACAAAGACCATGACGGT

GATTATAAAGATCATGACATCGATTACAAGGATGACGATGACAAGGCTGCAGGA

(SEQ ID NO: 4)

MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPG

EKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDELDNEENEDIL

EDIVLTLTLFEDREMIEERLKTYAHLEDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDELKSDGFANRNE

MQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILOTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFL

KDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVET

RQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDERKDFOFYKVREINNYHHAHDAYLNAVVGTALIKKY

PKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGR

DFATVRKVLSMPOVNIVKKTEVOTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY

VNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

In some embodiments, wild type Cas9 corresponds to Cas9 from Streptococcus pyogenes (NCBI Reference Sequence: NC_002737.2. SEQ ID NO: 282 (nucleotide); and Uniport Reference Sequence: Q99ZW2. SEQ ID NO: 9 (amino acid).

(SEQ ID NO: 282)

ATGGATAAGAAATACTCAATAGGCTTAGATATCGGCACAAATAGCGTCGGATGGGCGGTGATCACTGATGAATATAA

GGTTCCGTCTAAAAAGTTCAAGGTTCTGGGAAATACAGACCGCCACAGTATCAAAAAAAATCTTATAGGGGCTCTTT

TATTTGACAGTGGAGAGACAGCGGAAGCGACTCGTCTCAAACGGACAGCTCGTAGAAGGTATACACGTCGGAAGAAT

CGTATTTGTTATCTACAGGAGATTTTTTCAAATGAGATGGCGAAAGTAGATGATAGTTTCTTTCATCGACTTGAAGA

GTCTTTTTTGGTGGAAGAAGACAAGAAGCATGAACGTCATCCTATTTTTGGAAATATAGTAGATGAAGTTGCTTATC

ATGAGAAATATCCAACTATCTATCATCTGCGAAAAAAATTGGTAGATTCTACTGATAAAGCGGATTTGCGCTTAATC

TATTTGGCCTTAGCGCATATGATTAAGTTTCGTGGTCATTTTTTGATTGAGGGAGATTTAAATCCTGATAATAGTGA

TGTGGACAAACTATTTATCCAGTTGGTACAAACCTACAATCAATTATTTGAAGAAAACCCTATTAACGCAAGTGGAG

TAGATGCTAAAGCGATTCTTTCTGCACGATTGAGTAAATCAAGACGATTAGAAAATCTCATTGCTCAGCTCCCCGGT

GAGAAGAAAAATGGCTTATTTGGGAATCTCATTGCTTTGTCATTGGGTTTGACCCCTAATTTTAAATCAAATTTTGA

TTTGGCAGAAGATGCTAAATTACAGCTTTCAAAAGATACTTACGATGATGATTTAGATAATTTATTGGCGCAAATTG

GAGATCAATATGCTGATTTGTTTTTGGCAGCTAAGAATTTATCAGATGCTATTTTACTTTCAGATATCCTAAGAGTA

AATACTGAAATAACTAAGGCTCCCCTATCAGCTTCAATGATTAAACGCTACGATGAACATCATCAAGACTTGACTCT

TTTAAAAGCTTTAGTTCGACAACAACTTCCAGAAAAGTATAAAGAAATCTTTTTTGATCAATCAAAAAACGGATATG

CAGGTTATATTGATGGGGGAGCTAGCCAAGAAGAATTTTATAAATTTATCAAACCAATTTTAGAAAAAATGGATGGT

ACTGAGGAATTATTGGTGAAACTAAATCGTGAAGATTTGCTGCGCAAGCAACGGACCTTTGACAACGGCTCTATTCC

CCATCAAATTCACTTGGGTGAGCTGCATGCTATTTTGAGAAGACAAGAAGACTTTTATCCATTTTTAAAAGACAATC

GTGAGAAGATTGAAAAAATCTTGACTTTTCGAATTCCTTATTATGTTGGTCCATTGGCGCGTGGCAATAGTCGTTTT

GCATGGATGACTCGGAAGTCTGAAGAAACAATTACCCCATGGAATTTTGAAGAAGTTGTCGATAAAGGTGCTTCAGC

TCAATCATTTATTGAACGCATGACAAACTTTGATAAAAATCTTCCAAATGAAAAAGTACTACCAAAACATAGTTTGC

TTTATGAGTATTTTACGGTTTATAACGAATTGACAAAGGTCAAATATGTTACTGAAGGAATGCGAAAACCAGCATTT

CTTTCAGGTGAACAGAAGAAAGCCATTGTTGATTTACTCTTCAAAACAAATCGAAAAGTAACCGTTAAGCAATTAAA

AGAAGATTATTTCAAAAAAATAGAATGTTTTGATAGTGTTGAAATTTCAGGAGTTGAAGATAGATTTAATGCTTCAT

TAGGTACCTACCATGATTTGCTAAAAATTATTAAAGATAAAGATTTTTTGGATAATGAAGAAAATGAAGATATCTTA

GAGGATATTGTTTTAACATTGACCTTATTTGAAGATAGGGAGATGATTGAGGAAAGACTTAAAACATATGCTCACCT

CTTTGATGATAAGGTGATGAAACAGCTTAAACGTCGCCGTTATACTGGTTGGGGACGTTTGTCTCGAAAATTGATTA

ATGGTATTAGGGATAAGCAATCTGGCAAAACAATATTAGATTTTTTGAAATCAGATGGTTTTGCCAATCGCAATTTT

ATGCAGCTGATCCATGATGATAGTTTGACATTTAAAGAAGACATTCAAAAAGCACAAGTGTCTGGACAAGGCGATAG

TTTACATGAACATATTGCAAATTTAGCTGGTAGCCCTGCTATTAAAAAAGGTATTTTACAGACTGTAAAAGTTGTTG

ATGAATTGGTCAAAGTAATGGGGCGGCATAAGCCAGAAAATATCGTTATTGAAATGGCACGTGAAAATCAGACAACT

CAAAAGGGCCAGAAAAATTCGCGAGAGCGTATGAAACGAATCGAAGAAGGTATCAAAGAATTAGGAAGTCAGATTCT

TAAAGAGCATCCTGTTGAAAATACTCAATTGCAAAATGAAAAGCTCTATCTCTATTATCTCCAAAATGGAAGAGACA

TGTATGTGGACCAAGAATTAGATATTAATCGTTTAAGTGATTATGATGTCGATCACATTGTTCCACAAAGTTTCCTT

AAAGACGATTCAATAGACAATAAGGTCTTAACGCGTTCTGATAAAAATCGTGGTAAATCGGATAACGTTCCAAGTGA

AGAAGTAGTCAAAAAGATGAAAAACTATTGGAGACAACTTCTAAACGCCAAGTTAATCACTCAACGTAAGTTTGATA

ATTTAACGAAAGCTGAACGTGGAGGTTTGAGTGAACTTGATAAAGCTGGTTTTATCAAACGCCAATTGGTTGAAACT

CGCCAAATCACTAAGCATGTGGCACAAATTTTGGATAGTCGCATGAATACTAAATACGATGAAAATGATAAACTTAT

TCGAGAGGTTAAAGTGATTACCTTAAAATCTAAATTAGTTTCTGACTTCCGAAAAGATTTCCAATTCTATAAAGTAC

GTGAGATTAACAATTACCATCATGCCCATGATGCGTATCTAAATGCCGTCGTTGGAACTGCTTTGATTAAGAAATAT

CCAAAACTTGAATCGGAGTTTGTCTATGGTGATTATAAAGTTTATGATGTTCGTAAAATGATTGCTAAGTCTGAGCA

AGAAATAGGCAAAGCAACCGCAAAATATTTCTTTTACTCTAATATCATGAACTTCTTCAAAACAGAAATTACACTTG

CAAATGGAGAGATTCGCAAACGCCCTCTAATCGAAACTAATGGGGAAACTGGAGAAATTGTCTGGGATAAAGGGCGA

GATTTTGCCACAGTGCGCAAAGTATTGTCCATGCCCCAAGTCAATATTGTCAAGAAAACAGAAGTACAGACAGGCGG

ATTCTCCAAGGAGTCAATTTTACCAAAAAGAAATTCGGACAAGCTTATTGCTCGTAAAAAAGACTGGGATCCAAAAA

AATATGGTGGTTTTGATAGTCCAACGGTAGCTTATTCAGTCCTAGTGGTTGCTAAGGTGGAAAAAGGGAAATCGAAG

AAGTTAAAATCCGTTAAAGAGTTACTAGGGATCACAATTATGGAAAGAAGTTCCTTTGAAAAAAATCCGATTGACTT

TTTAGAAGCTAAAGGATATAAGGAAGTTAAAAAAGACTTAATCATTAAACTACCTAAATATAGTCTTTTTGAGTTAG

AAAACGGTCGTAAACGGATGCTGGCTAGTGCCGGAGAATTACAAAAAGGAAATGAGCTGGCTCTGCCAAGCAAATAT

GTGAATTTTTTATATTTAGCTAGTCATTATGAAAAGTTGAAGGGTAGTCCAGAAGATAACGAACAAAAACAATTGTT

TGTGGAGCAGCATAAGCATTATTTAGATGAGATTATTGAGCAAATCAGTGAATTTTCTAAGCGTGTTATTTTAGCAG

ATGCCAATTTAGATAAAGTTCTTAGTGCATATAACAAACATAGAGACAAACCAATACGTGAACAAGCAGAAAATATT

ATTCATTTATTTACGTTGACGAATCTTGGAGCTCCCGCTGCTTTTAAATATTTTGATACAACAATTGATCGTAAACG

ATATACGTCTACAAAAGAAGTTTTAGATGCCACTCTTATCCATCAATCCATCACTGGTCTTTATGAAACACGCATTG

ATTTGAGTCAGCTAGGAGGTGACTGA

(SEQ ID NO: 9)

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLEDSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPG

EKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDELDNEENEDIL

EDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNF

MQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFL

KDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVET

ROITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDERKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKY

PKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGR

DFATVRKVLSMPOVNIVKKTEVOTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY

VNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

In some embodiments, Cas9 refers to Cas9 from: Corynebacterium ulcerans (NCBI Refs: NC_015683.1, NC_017317.1); Corynebacterium diphtheria (NCBI Refs: NC_016782.1, NC_016786.1); Spiroplasma syrphidicola (NCBI Ref: NC_021284.1); Prevotella intermedia (NCBI Ref: NC_017861.1); Spiroplasma taiwanense (NCBI Ref: NC_021846.1); Streptococcus iniae (NCBI Ref: NC_021314.1); Belliella baltica (NCBI Ref: NC_018010.1); Psychroflexus torquisI (NCBI Ref: NC_018721.1); Streptococcus thermophilus (NCBI Ref: YP_820832.1); Listeria innocua (NCBI Ref: NP_472073.1); Campylobacter jejuni (NCBI Ref: YP_002344900.1); or Neisseria. meningitidis (NCBI Ref: YP_002342100.1) or to a Cas9 from any of the organisms listed in Example 3.

In some embodiments, dCas9 corresponds to, or comprises in part or in whole, a Cas9 amino acid sequence having one or more mutations that inactivate the Cas9 nuclease activity. For example, in some embodiments, a dCas9 domain comprises D10A and/or H840A mutation.

dCas9 (D10A and H840A):

(SEQ ID NO: 8)

MDKKYSIGLA*IGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRK

NRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTDKADL

RLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIA

QLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILL

SDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPI

LEKMDGTEELLVKLNREDLLRKORTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPL

ARGNSRFAWMTRKSEETITPWNFEE*VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT

EGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKOLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDEL

DNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG*RLSRKLINGIRDKQSGKTILDEL

embedded image

VAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQK

GNELALPSKYVNFLYLASHYEKLKGSPEDNEQKOLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRD

KPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

In some embodiments, Cas9 corresponds to, or comprises in part or in whole, a Cas9 amino acid sequence having one or more mutations that alter Cas9's nuclease activity. In some embodiments, Cas9 may be a Cas9 nickase, which is a version of Cas9 that generates a single-stranded DNA break at a specific location based on a co-expressed gRNA-defined target sequence, rather than a double-strand DNA break. For example, in some embodiments, a Cas9 domain comprises D10A mutation (e.g., SEQ ID NO: 301) and/or an H840A mutation (e.g., SEQ ID NO: 302). Exemplary Cas9 nickases are shown below. However, it should be appreciated that additional Cas9 nickases that generate a single-stranded DNA break of a DNA duplex would be apparent to the skilled artisan and are within the scope of this disclosure.

Cas9 D10A nickase:

(SEQ ID NO: 301)

MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPG

EKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDELDNEENEDIL

EDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNF

MQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILOTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFL

KDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKROLVET

RQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKY

PKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGR

DFATVRKVLSMPOVNIVKKTEVOTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY

VNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

Cas9 H840A nickase:

(SEQ ID NO: 302)

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLEDSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPG

EKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDELDNEENEDIL

EDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNE

MQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILOTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFL

KDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVET

RQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDERKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKY

PKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGR

DFATVRKVLSMPOVNIVKKTEVOTGGFSKESILPKRNSDKLIARKKDWDPKKYGGEDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY

VNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(single underline: HNH domain; double underline: RuvC domain)

In other embodiments, dCas9 variants having mutations other than D10A and H840A are provided, which, e.g., result in nuclease-inactivated Cas9 (dCas9). Such mutations, by way of example, include other amino acid substitutions at D10 and H820, or other substitutions within the nuclease domains of Cas9 (e.g., substitutions in the HNH nuclease subdomain and/or the RuvC1 subdomain). In some embodiments, variants or homologues of dCas9 (e.g., variants of SEQ ID NO: 9) are provided which are at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% identical to SEQ ID NO: 9. In some embodiments, variants of dCas9 (e.g., variants of SEQ ID NO: 9) are provided having amino acid sequences which are shorter, or longer than SEQ ID NO: 9, by about 5 amino acids, by about 10 amino acids, by about 15 amino acids, by about 20 amino acids, by about 25 amino acids, by about 30 amino acids, by about 40 amino acids, by about 50 amino acids, by about 75 amino acids, by about 100 amino acids, or more.

In some embodiments, Cas9 fusion proteins as provided herein comprise the full-length amino acid sequence of a Cas9 protein, e.g., one of the sequences provided above. In other embodiments, however, fusion proteins as provided herein do not comprise a full-length Cas9 sequence, but only a fragment thereof. For example, in some embodiments, a Cas9 fusion protein provided herein comprises a Cas9 fragment, wherein the fragment binds crRNA and tracrRNA or a sgRNA, but does not comprise a functional nuclease domain, e.g., it comprises only a truncated version of a nuclease domain or no nuclease domain at all. Exemplary amino acid sequences of suitable Cas9 domains and Cas9 fragments are provided herein, and additional suitable sequences of Cas9 domains and Cas9 fragments will be apparent to those of skill in the art. In some embodiments, a Cas9 fragment is at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% identical, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% of the amino acid length of a corresponding wild type Cas9 protein. In some embodiments, a Cas9 fragment comprises at least at least 100 amino acids in length. In some embodiments, the Cas9 fragment is at least 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1100, 1150, 1200, 1250, 1300, 1350, 1400, 1450, 1500, 1550, or at least 1600 amino acids of a corresponding wild type Cas9 protein. In some embodiments, the Cas9 fragment comprises an amino acid sequence that has at least 10, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, at least 100, at least 150, at least 200, at least 250, at least 300, at least 350, at least 400, at least 500, at least 600, at least 700, at least 800, at least 900, at least 1000, at least 1100, or at least 1200 identical contiguous amino acid residues of a corresponding wild type Cas9 protein.

Cas9. In some embodiments, Cas9 refers to Cas9 from: Corynebacterium ulcerans (NCBI Refs: NC_015683.1, NC_017317.1); Corynebacterium diphtheria (NCBI Refs: NC_016782.1, NC_016786.1); Spiroplasma syrphidicola (NCBI Ref: NC_021284.1); Prevotella intermedia (NCBI Ref: NC_017861.1); Spiroplasma taiwanense (NCBI Ref: NC_021846.1); Streptococcus iniae (NCBI Ref: NC_021314.1); Belliella baltica (NCBI Ref: NC_018010.1); Psychroflexus torquisI (NCBI Ref: NC_018721.1); Streptococcus thermophilus (NCBI Ref: YP_820832.1); Listeria innocua (NCBI Ref: NP_472073.1); Campylobacter jejuni (NCBI Ref: YP_002344900.1); or Neisseria. meningitidis (NCBI Ref: YP_002342100.1).

The term “deaminase” or “deaminase domain,” as used herein, refers to a protein or enzyme that catalyzes a deamination reaction. In some embodiments, the deaminase or deaminase domain is a cytidine deaminase, catalyzing the hydrolytic deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively. In some embodiments, the deaminase or deaminase domain is a cytosine deaminase, catalyzing the hydrolytic deamination of cytosine to uracil. In some embodiments, the deaminase or deaminase domain is a naturally-occurring deaminase from an organism, such as a human, chimpanzee, gorilla, monkey, cow, dog, rat, or mouse. In some embodiments, the deaminase or deaminase domain is a variant of a naturally-occurring deaminase from an organism, that does not occur in nature. For example, in some embodiments, the deaminase or deaminase domain is at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75% at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to a naturally-occurring deaminase from an organism.

The term “effective amount,” as used herein, refers to an amount of a biologically active agent that is sufficient to elicit a desired biological response. For example, in some embodiments, an effective amount of a nuclease may refer to the amount of the nuclease that is sufficient to induce cleavage of a target site specifically bound and cleaved by the nuclease. In some embodiments, an effective amount of a fusion protein provided herein, e.g., of a fusion protein comprising a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain) may refer to the amount of the fusion protein that is sufficient to induce editing of a target site specifically bound and edited by the fusion protein. As will be appreciated by the skilled artisan, the effective amount of an agent, e.g., a fusion protein, a nuclease, a deaminase, a recombinase, a hybrid protein, a protein dimer, a complex of a protein (or protein dimer) and a polynucleotide, or a polynucleotide, may vary depending on various factors such as, for example, on the desired biological response, e.g., on the specific allele, genome, or target site to be edited; on the cell or tissue being targeted; and on the agent being used.

The term “immediately adjacent” as used in the context of two nucleic acid sequences refers to two sequences that directly abut each other as part of the same nucleic acid molecule and are not separated by one or more nucleotides. Accordingly, sequences are immediately adjacent, when the nucleotide at the 3′-end of one of the sequences is directly connected to nucleotide at the 5′-end of the other sequence via a phosphodiester bond.

The term “linker,” as used herein, refers to a chemical group or a molecule linking two molecules or moieties, e.g., two domains of a fusion protein, such as, for example, a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain). In some embodiments, a linker joins a gRNA binding domain of an RNA-programmable nuclease, including a Cas9 nuclease domain, and the catalytic domain of a nucleic-acid editing protein. In some embodiments, a linker joins a dCas9 and a nucleic-acid editing protein. Typically, the linker is positioned between, or flanked by, two groups, molecules, or other moieties and connected to each one via a covalent bond, thus connecting the two. In some embodiments, the linker is an amino acid or a plurality of amino acids (e.g., a peptide or protein). In some embodiments, the linker is an organic molecule, group, polymer, or chemical moiety. In some embodiments, the linker is 5-100 amino acids in length, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-150, or 150-200 amino acids in length. Longer or shorter linkers are also contemplated.

The term “mutation,” as used herein, refers to a substitution of a residue within a sequence, e.g., a nucleic acid or amino acid sequence, with another residue, or a deletion or insertion of one or more residues within a sequence. Mutations are typically described herein by identifying the original residue followed by the position of the residue within the sequence and by the identity of the newly substituted residue. Various methods for making the amino acid substitutions (mutations) provided herein are well known in the art, and are provided by, for example, Green and Sambrook, Molecular Cloning: A Laboratory Manual (4^thed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)).

The terms “nucleic acid” and “nucleic acid molecule,” as used herein, refer to a compound comprising a nucleobase and an acidic moiety, e.g., a nucleoside, a nucleotide, or a polymer of nucleotides. Typically, polymeric nucleic acids, e.g., nucleic acid molecules comprising three or more nucleotides are linear molecules, in which adjacent nucleotides are linked to each other via a phosphodiester linkage. In some embodiments, “nucleic acid” refers to individual nucleic acid residues (e.g. nucleotides and/or nucleosides). In some embodiments, “nucleic acid” refers to an oligonucleotide chain comprising three or more individual nucleotide residues. As used herein, the terms “oligonucleotide” and “polynucleotide” can be used interchangeably to refer to a polymer of nucleotides (e.g., a string of at least three nucleotides). In some embodiments, “nucleic acid” encompasses RNA as well as single and/or double-stranded DNA. Nucleic acids may be naturally occurring, for example, in the context of a genome, a transcript, mRNA, tRNA, rRNA, siRNA, snRNA, a plasmid, cosmid, chromosome, chromatid, or other naturally occurring nucleic acid molecule. On the other hand, a nucleic acid molecule may be a non-naturally occurring molecule, e.g., a recombinant DNA or RNA, an artificial chromosome, an engineered genome, or fragment thereof, or a synthetic DNA, RNA, DNA/RNA hybrid, or including non-naturally occurring nucleotides or nucleosides. Furthermore, the terms “nucleic acid,” “DNA,” “RNA,” and/or similar terms include nucleic acid analogs, e.g., analogs having other than a phosphodiester backbone. Nucleic acids can be purified from natural sources, produced using recombinant expression systems and optionally purified, chemically synthesized, etc. Where appropriate, e.g., in the case of chemically synthesized molecules, nucleic acids can comprise nucleoside analogs such as analogs having chemically modified bases or sugars, and backbone modifications. A nucleic acid sequence is presented in the 5′ to 3′ direction unless otherwise indicated. In some embodiments, a nucleic acid is or comprises natural nucleosides (e.g. adenosine, thymidine, guanosine, cytidine, uridine, deoxyadenosine, deoxythymidine, deoxyguanosine, and deoxycytidine); nucleoside analogs (e.g., 2-aminoadenosine, 2-thiothymidine, inosine, pyrrolo-pyrimidine, 3-methyl adenosine, 5-methylcytidine, 2-aminoadenosine, C5-bromouridine, C5-fluorouridine, C5-iodouridine, C5-propynyl-uridine, C5-propynyl-cytidine, C5-methylcytidine, 2-aminoadenosine, 7-deazaadenosine, 7-deazaguanosine, 8-oxoadenosine, 8-oxoguanosine, O (6)-methylguanine, and 2-thiocytidine); chemically modified bases; biologically modified bases (e.g., methylated bases); intercalated bases; modified sugars (e.g., 2′-fluororibose, ribose, 2′-deoxyribose, arabinose, and hexose); and/or modified phosphate groups (e.g., phosphorothioates and 5′-N-phosphoramidite linkages). In some embodiments, an RNA is an RNA associated with the Cas9 system. For example, the RNA may be a CRISPR RNA (crRNA), a trans-encoded small RNA (tracrRNA), a single guide RNA (sgRNA), or a guide RNA (gRNA).

The term “proliferative disease,” as used herein, refers to any disease in which cell or tissue homeostasis is disturbed in that a cell or cell population exhibits an abnormally elevated proliferation rate. Proliferative diseases include hyperproliferative diseases, such as pre-neoplastic hyperplastic conditions and neoplastic diseases. Neoplastic diseases are characterized by an abnormal proliferation of cells and include both benign and malignant neoplasias. Malignant neoplasia is also referred to as cancer.

The terms “protein,” “peptide,” and “polypeptide” are used interchangeably herein, and refer to a polymer of amino acid residues linked together by peptide (amide) bonds. The terms refer to a protein, peptide, or polypeptide of any size, structure, or function. Typically, a protein, peptide, or polypeptide will be at least three amino acids long. A protein, peptide, or polypeptide may refer to an individual protein or a collection of proteins. One or more of the amino acids in a protein, peptide, or polypeptide may be modified, for example, by the addition of a chemical entity such as a carbohydrate group, a hydroxyl group, a phosphate group, a farnesyl group, an isofarnesyl group, a fatty acid group, a linker for conjugation, functionalization, or other modification, etc. A protein, peptide, or polypeptide may also be a single molecule or may be a multi-molecular complex. A protein, peptide, or polypeptide may be just a fragment of a naturally occurring protein or peptide. A protein, peptide, or polypeptide may be naturally occurring, recombinant, or synthetic, or any combination thereof. The term “fusion protein” as used herein refers to a hybrid polypeptide which comprises protein domains from at least two different proteins. One protein may be located at the amino-terminal (N-terminal) portion of the fusion protein or at the carboxy-terminal (C-terminal) protein thus forming an “amino-terminal fusion protein” or a “carboxy-terminal fusion protein,” respectively. A protein may comprise different domains, for example, a nucleic acid binding domain (e.g., the gRNA binding domain of Cas9 that directs the binding of the protein to a target site) and a nucleic acid cleavage domain or a catalytic domain of a nucleic-acid editing protein. In some embodiments, a protein comprises a proteinaceous part, e.g., an amino acid sequence constituting a nucleic acid binding domain, and an organic compound, e.g., a compound that can act as a nucleic acid cleavage agent. In some embodiments, a protein is in a complex with, or is in association with, a nucleic acid, e.g., RNA. Any of the proteins provided herein may be produced by any method known in the art. For example, the proteins provided herein may be produced via recombinant protein expression and purification, which is especially suited for fusion proteins comprising a peptide linker. Methods for recombinant protein expression and purification are well known, and include those described by Green and Sambrook, Molecular Cloning: A Laboratory Manual (4^thed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)), the entire contents of which are incorporated herein by reference.

The term “RNA-programmable nuclease,” and “RNA-guided nuclease” are used interchangeably herein and refer to a nuclease that forms a complex with (e.g., binds or associates with) one or more RNA that is not a target for cleavage. In some embodiments, an RNA-programmable nuclease, when in a complex with an RNA, may be referred to as a nuclease: RNA complex. Typically, the bound RNA(s) is referred to as a guide RNA (gRNA). gRNAs can exist as a complex of two or more RNAs, or as a single RNA molecule. gRNAs that exist as a single RNA molecule may be referred to as single-guide RNAs (sgRNAs), though “gRNA” is used interchangeably to refer to guide RNAs that exist as either single molecules or as a complex of two or more molecules. Typically, gRNAs that exist as single RNA species comprise two domains: (1) a domain that shares homology to a target nucleic acid (e.g., and directs binding of a Cas9 complex to the target); and (2) a domain that binds a Cas9 protein. In some embodiments, domain (2) corresponds to a sequence known as a tracrRNA, and comprises a stem-loop structure. For example, in some embodiments, domain (2) is identical or homologous to a tracrRNA as provided in Jinek et al., Science 337:816-821 (2012), the entire contents of which is incorporated herein by reference. Other examples of gRNAs (e.g., those including domain 2) can be found in U.S. Provisional Patent Application, U.S. Ser. No. 61/874,682, filed Sep. 6, 2013, entitled “Switchable Cas9 Nucleases and Uses Thereof,” and U.S. Provisional Patent Application, U.S. Ser. No. 61/874,746, filed Sep. 6, 2013, entitled “Delivery System For Functional Nucleases,” the entire contents of each are hereby incorporated by reference in their entirety. In some embodiments, a gRNA comprises two or more of domains (1) and (2), and may be referred to as an “extended gRNA.” For example, an extended gRNA will, e.g., bind two or more Cas9 proteins and bind a target nucleic acid at two or more distinct regions, as described herein. The gRNA comprises a nucleotide sequence that complements a target site, which mediates binding of the nuclease/RNA complex to said target site, providing the sequence specificity of the nuclease: RNA complex. In some embodiments, the RNA-programmable nuclease is the (CRISPR-associated system) Cas9 endonuclease, for example Cas9 (Csn1) from Streptococcus pyogenes (see, e.g., “Complete genome sequence of an MI strain of Streptococcus pyogenes.” Ferretti J. J., McShan W. M., Ajdic D. J., Savic D. J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A. N., Kenton S., Lai H. S., Lin S. P., Qian Y., Jia H. G., Najar F. Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S. W., Roc B. A., Mclaughlin R. E., Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663 (2001); “CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.” Deltcheva E., Chylinski K., Sharma C. M., Gonzales K., Chao Y., Pirzada Z. A., Eckert M. R., Vogel J., Charpentier E., Nature 471:602-607 (2011); and “A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.” Jinek M., Chylinski K., Fonfara I., Hauer M., Doudna J. A., Charpentier E. Science 337:816-821 (2012), the entire contents of each of which are incorporated herein by reference.

Because RNA-programmable nucleases (e.g., Cas9) use RNA:DNA hybridization to target DNA cleavage sites, these proteins are able to be targeted, in principle, to any sequence specified by the guide RNA. Methods of using RNA-programmable nucleases, such as Cas9, for site-specific cleavage (e.g., to modify a genome) are known in the art (see e.g., Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013); Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013); Hwang, W. Y. et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nature biotechnology 31, 227-229 (2013); Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, c00471 (2013); Dicarlo, J. E. et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic acids research (2013); Jiang, W. et al. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nature biotechnology 31, 233-239 (2013); the entire contents of each of which are incorporated herein by reference).

The term “subject,” as used herein, refers to an individual organism, for example, an individual mammal. In some embodiments, the subject is a human. In some embodiments, the subject is a non-human mammal. In some embodiments, the subject is a non-human primate. In some embodiments, the subject is a rodent. In some embodiments, the subject is a sheep, a goat, a cattle, a cat, or a dog. In some embodiments, the subject is a vertebrate, an amphibian, a reptile, a fish, an insect, a fly, or a nematode. In some embodiments, the subject is a research animal. In some embodiments, the subject is genetically engineered, e.g., a genetically engineered non-human subject. The subject may be of either sex, of any age, and at any stage of development.

The term “target site” refers to a sequence within a nucleic acid molecule that is deaminated by a deaminase or a fusion protein comprising a deaminase (e.g., a dCas9-deaminase fusion protein provided herein).

The terms “treatment,” “treat,” and “treating,” refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. As used herein, the terms “treatment,” “treat,” and “treating” refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. In some embodiments, treatment may be administered after one or more symptoms have developed and/or after a disease has been diagnosed. In other embodiments, treatment may be administered in the absence of symptoms, e.g., to prevent or delay onset of a symptom or inhibit onset or progression of a disease. For example, treatment may be administered to a susceptible individual prior to the onset of symptoms (e.g., in light of a history of symptoms and/or in light of genetic or other susceptibility factors). Treatment may also be continued after symptoms have resolved, for example, to prevent or delay their recurrence.

The term “recombinant” as used herein in the context of proteins or nucleic acids refers to proteins or nucleic acids that do not occur in nature, but are the product of human engineering. For example, in some embodiments, a recombinant protein or nucleic acid molecule comprises an amino acid or nucleotide sequence that comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations as compared to any naturally occurring sequence.

The term “nucleic acid editing enzyme” as used herein refers to proteins that are able to modify a nucleic acids or one or more nucleotide bases of a nucleic acid. For example, in some embodiments, a nucleic acid editing enzyme is a deaminase, which can catalyze C to T or G to A changes. Other suitable nucleic acid editing enzyme that may be used in accordance with this disclosure include, without limitation, a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, or acetyltransferase.

DETAILED DESCRIPTION OF CERTAIN EMBODIMENTS OF THE INVENTION

Some aspects of this disclosure provide recombinant Cas9 proteins that efficiently target DNA sequences that do not comprise the canonical PAM sequence (5′-NGG-3′, where N is any nucleotide, for example A, T, G, or C) at their 3′-ends. In some embodiments, the Cas9 proteins provided herein comprise one or more mutations identified in directed evolution experiments using a target sequence library comprising randomized PAM sequences. The recombinant non-PAM restricted Cas9 proteins provided herein are useful for targeting DNA sequences that do not comprise the canonical PAM sequence at their 3′-end and thus greatly extend the usefulness of Cas9 technology for gene editing.

Some aspects of this disclosure provide fusion proteins that comprise a Cas9 protein and an effector domain, for example, a DNA-editing domain, such as, e.g., a deaminase domain. The deamination of a nucleobase by a deaminase can lead to a point mutation at the specific residue, which is referred to herein as nucleic acid editing. Fusion proteins comprising a Cas9 protein or variant thereof and a DNA-editing domain can thus be used for the targeted editing of nucleic acid sequences. Such fusion proteins are useful for targeted editing of DNA in vitro, e.g., for the generation of mutant cells or animals; for the introduction of targeted mutations, e.g., for the correction of genetic defects in cells ex vivo, e.g., in cells obtained from a subject that are subsequently re-introduced into the same or another subject; and for the introduction of targeted mutations, e.g., the correction of genetic defects or the introduction of deactivating mutations in disease-associated genes in a subject in vivo. Typically, the Cas9 protein of the fusion proteins described herein does not have any nuclease activity but instead is a Cas9 fragment or a dCas9 protein. Methods for the use of Cas9 fusion proteins as described herein are also provided.

Non-limiting, exemplary nuclease-inactive Cas9 proteins are provided herein. One exemplary suitable nuclease-inactive Cas9 protein is the D10A/H840A Cas9 protein mutant:

MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKN

RICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLI

YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPG

EKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRV

NTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDG

TEELLVKLNREDLLRKQRTEDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRF

AWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAF

LSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDELDNEENEDIL

EDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNE

MQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTT

QKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFL

KDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKEDNLTKAERGGLSELDKAGFIKRQLVET

RQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKY

PKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIEINGETGEIVWDKGR

DFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSK

KLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY

VNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(SEQ ID NO: 262; see, e.g., Qi et al., Repurposing CRISPR as an RNA-guided

platform for sequence-specific control of gene expression.

Cell. 2013; 152(5): 1173-83, the entire contents of which are incorporated

herein by reference).

Additional suitable nuclease-inactive Cas9 proteins will be apparent to those of skill in the art based on this disclosure. Such additional exemplary suitable nuclease-inactive Cas9 proteins include, but are not limited to, D10A, D839A, H840A, N863A, D10A/D839A, D10A/H840A, D10A/N863A, D839A/H840A, D839A/N863A, D10A/D839A/H840A, and D10A/D839A/H840A/N863A mutant proteins (See, e.g., Prashant et al., CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. 2013; 31 (9): 833-838, the entire contents of which are incorporated herein by reference).

Recombinant Cas9 Proteins

In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid at the corresponding position.

In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

Recombinant Cas9 Proteins with Activity on Non-Canonical PAMs

In some embodiments, the Cas9 protein exhibits activity on a target sequence having a 3′-end that is not directly adjacent to the canonical PAM sequence (5′-NGG-3′) that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence. In some embodiments, the 3′-end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence. In some embodiments, the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay. In some embodiments, the transcriptional activation assay is a reporter activation assay, such as a GFP activation assay. Exemplary methods for measuring binding activity (e.g., of Cas9) using transcriptional activation assays are known in the art and would be apparent to the skilled artisan. For example, methods for measuring Cas9 activity using the tripartite activator VPR have been described in Chavez A., et al., “Highly efficient Cas9-mediated transcriptional programming.” Nature Methods 12, 326-328 (2015); the entire contents of which are incorporated by reference herein.

In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid at the corresponding position.

In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5′-NGG-3′) at its 3′-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 further comprises a histidine residue at position 840 as provided in SEQ ID NO: 9, or a corresponding histidine residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. Without wishing to be bound by any particular theory, the presence of the catalytic residue H840 allows Cas9 to cleave the non-targeted strand, i.e., the strand bound by the sgRNA. In some embodiments, a Cas9 having an amino acid residue other than histidine at position 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 may be changed or reverted such that amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 is histidine.

In some embodiments, the Cas9 protein exhibits an activity on a target sequence having a 3′-end that is not directly adjacent to the canonical PAM sequence (5′-NGG-3′) that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence. In some embodiments, the 3′-end of the target sequence is directly adjacent to an AAA, AAC, AAG, AAT, CAA, CAC, CAG, CAT, GAA, GAC, GAG, GAT, TAA, TAC, TAG, TAT, ACA, ACC, ACG, ACT, CCA, CCC, CCG, CCT, GCA, GCC, GCG, GCT, TCA, TCC, TCG, TCT, AGA, AGC, AGT, CGA, CGC, CGT, GGA, GGC, GGT, TGA, TGC, TGT, ATA, ATC, ATG, ATT, CTA, CTC, CTG, CTT, GTA, GTC, GTG, GTT, TTA, TTC, TTG, or TTT PAM sequence.

In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the Cas9 protein comprises the combination of mutations selected from the group consisting of (X480K, X543D, and X1219V); (X262T, X409I, X480K, X543D, X694I, and X1219V); (X294R, X480K, X543D, X1219V, X1256K, and X1362P); (X294R, X480K, X543D, X1219V, and X1256K); (X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K); and (X262T, X405I, X409I, X480K, X543D, X694I, and X1219V) of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises the combination of mutations selected from the group consisting of (E480K, E543D, and E1219V); (A262T, S409I, E480K, E543D, M694I, and E1219V); (K294R, E480K, E543D, E1219V, Q1256K, and L1362P); (K294R, E480K, E543D, E1219V, and Q1256K); (S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K); and (A262T, F405I, S409I, E480K, E543D, M694I, and E1219V) of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A and an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations at an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not comprise the canonical PAM (5′-NGG-3′) at its 3′-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 further comprises a histidine residue at position 840 as provided in SEQ ID NO: 9, or a corresponding histidine residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. Without wishing to be bound by any particular theory, the presence of the catalytic residue H840 allows Cas9 to cleave the non-targeted strand, i.e., the strand bound by the sgRNA. In some embodiments, a Cas9 having an amino acid residue other than histidine at position 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 may be changed or reverted such that amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 is histidine.

Cas9 Fusion Proteins

Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein as provided herein that is fused to a second protein, or a “fusion partner”, such as an effector domain, thus forming a fusion protein. In some embodiments, the effector domain is fused to the N-terminus of the Cas9 protein. In some embodiments, the effector domain is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 protein and the effector domain are fused to each other via a linker. Suitable strategies for generating fusion proteins according to aspects of this disclosure using linkers or without the use of linkers will also be apparent to those of skill in the art in view of the instant disclosure and the knowledge in the art. For example, Gilbert et al., CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013; 154 (2): 442-51, showed that C-terminal fusions of Cas9 with VP64 using 2 NLS's as a linker (SPKKKRKVEAS, SEQ ID NO: 284), can be employed for transcriptional activation. Mali et al., CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol. 2013; 31 (9): 833-8, reported that C-terminal fusions with VP64 without linker can be employed for transcriptional activation. And Maeder et al., CRISPR RNA-guided activation of endogenous human genes. Nat Methods. 2013; 10:977-979, reported that C-terminal fusions with VP64 using a Gly Ser (SEQ ID NO: 5) linker can be used as transcriptional activators. Recently, dCas9-FokI nuclease fusions have successfully been generated and exhibit improved enzymatic specificity as compared to the parental Cas9 enzyme (In Guilinger J P, Thompson D B, Liu D R. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014; 32 (6): 577-82, and in Tsai S Q, Wyvekens N, Khayter C, Foden J A, Thapar V, Reyon D, Goodwin M J, Aryec M J, Joung J K. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol. 2014; 32 (6): 569-76. PMID: 24770325 a SGSETPGTSESATPES (SEQ ID NO: 7) or a GGGGS_n(SEQ ID NO: 5) linker was used in FokI-dCas9 fusion proteins, respectively). In some embodiments, the linker comprises a (GGGGS), (SEQ ID NO: 5), a (G)_n(SEQ ID NO: 5087), an (EAAAK)_n(SEQ ID NO: 6), a (GGS)_n(SEQ ID NO: 5088), an SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n(SEQ ID NO: 5089) motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, the effector domain comprises an enzymatic domain. Suitable effector domains include, without limitation a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, acetyltransferase, transcriptional activator, and transcriptional repressor.

The linker may be as simple as a covalent bond, or it may be a polymeric linker many atoms in length. In certain embodiments, the linker is a polypeptide or based on amino acids. In other embodiments, the linker is not peptide-like. In certain embodiments, the linker is a covalent bond (e.g., a carbon-carbon bond, disulfide bond, carbon-heteroatom bond, etc.). In certain embodiments, the linker is a carbon-nitrogen bond of an amide linkage. In certain embodiments, the linker is a cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic or heteroaliphatic linker. In certain embodiments, the linker is polymeric (e.g., polyethylene, polyethylene glycol, polyamide, polyester, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminoalkanoic acid. In certain embodiments, the linker comprises an aminoalkanoic acid (e.g., glycine, ethanoic acid, alanine, beta-alanine, 3-aminopropanoic acid, 4-aminobutanoic acid, 5-pentanoic acid, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminohexanoic acid (Ahx). In certain embodiments, the linker is based on a carbocyclic moiety (e.g., cyclopentane, cyclohexane). In other embodiments, the linker comprises a polyethylene glycol moiety (PEG). In other embodiments, the linker comprises amino acids. In certain embodiments, the linker comprises a peptide. In certain embodiments, the linker comprises an aryl or heteroaryl moiety. In certain embodiments, the linker is based on a phenyl ring. The linker may included functionalized moieties to facilitate attachment of a nucleophile (e.g., thiol, amino) from the peptide to the linker. Any electrophile may be used as part of the linker. Exemplary electrophiles include, but are not limited to, activated esters, activated amides, Michael acceptors, alkyl halides, aryl halides, acyl halides, and isothiocyanates.

In some embodiments, the effector domain comprises a effector enzyme. Suitable effector enzymes that may be used in accordance with this disclosure include nucleases, nickases, recombinases, and deaminases. However additional effector enzymes would be apparent to the skilled artisan and are within the scope of this disclosure. In other embodiments, the effector domain comprises a domain that modulates transcriptional activity. Such transcriptional modulating domains may be, without limitation, a transcriptional activator or transcriptional repressor domain.

In some embodiments, the effector domain is a effector domain. In some embodiments, the effector domain is a deaminase domain. In some embodiments, the deaminase is a cytosine deaminase or a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC1 deaminase. In some embodiments, the deaminase is an APOBEC2 deaminase. In some embodiments, the deaminase is an APOBEC3 deaminase. In some embodiments, the deaminase is an APOBEC3A deaminase. In some embodiments, the deaminase is an APOBEC3D deaminase. In some embodiments, the deaminase is an APOBEC3E deaminase. In some embodiments, the deaminase is an APOBEC3F deaminase. In some embodiments, the deaminase is an APOBEC3G deaminase. In some embodiments, the deaminase is an APOBEC3H deaminase. In some embodiments, the deaminase is an APOBEC4 deaminase. In some embodiments, the deaminase is an activation-induced deaminase (AID).

In some embodiments, the effector domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the deaminase domain of any one of SEQ ID NOs: 263-281.

In some embodiments, the effector domain is a nuclease domain. In some embodiments, the nuclease domain is a FokI DNA cleavage domain. In some embodiments, this disclosure provides dimers of the fusion proteins provided herein, e.g., dimers of fusion proteins may include a dimerizing nuclease domain.

In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences provided in SEQ ID NOs: 10-262, wherein the Cas9 protein comprises a RuvC and an HNH domain, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits activity on a target sequence that does not comprise the canonical PAM (5′-NGG-3′) at its 3′-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences provided in SEQ ID NOs: 10-262, wherein the Cas9 protein comprises a RuvC and an HNH domain, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, and 1256 of the amino acid sequence provided in SEQ ID NO: 9; wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein; and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not include the canonical PAM (5′-NGG-3′) at its 3′-end, as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

Some aspects of this disclosure provide fusion proteins comprising (i) a nuclease-inactive Cas9 protein; and (ii) a effector domain. In some embodiments, the effector domain is a DNA-editing domain. In some embodiments, the effector domain possesses deaminase activity. In some embodiments, the effector domain comprises or is a deaminase domain. In some embodiments, the deaminase is a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC1 family deaminase. In some embodiments, the deaminase is an activation-induced cytidine deaminase (AID). Some nucleic-acid editing domains as well as Cas9 fusion proteins including such domains are described in detail herein. Additional suitable effector domains will be apparent to the skilled artisan based on this disclosure. In some embodiments, the nucleic-acid editing domain is a FokI nuclease domain.

The instant disclosure provides Cas9:effector domain fusion proteins of various configurations. In some embodiments, the effector domain is fused to the N-terminus of the Cas9 protein. In some embodiments, the effector domain is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 protein and the effector domain are fused via a linker. In some embodiments, the linker comprises (GGGGS)_n(SEQ ID NO: 5), (G)_n(SEQ ID NO: 5087), (EAAAK)_n(SEQ ID NO: 6), (GGS)_n(SEQ ID NO: 5088), or SGSETPGTSESATPES (SEQ ID NO: 7) motif (see, e.g., Guilinger J P, Thompson D B, Liu D R. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014; 32 (6): 577-82; the entire contents are incorporated herein by reference), or an (XP), (SEQ ID NO: 5089) motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30, or, if more than one linker or more than one linker motif is present, any combination thereof. Additional suitable linker motifs and linker configurations will be apparent to those of skill in the art. In some embodiments, suitable linker motifs and configurations include those described in Chen et al., Fusion protein linkers: property, design and functionality. Adv Drug Deliv Rev. 2013; 65 (10): 1357-69, the entire contents of which are incorporated herein by reference. Additional suitable linker sequences will be apparent to those of skill in the art based on the instant disclosure and knowledge in the art.

In some embodiments, the general architecture of exemplary Cas9 fusion proteins provided herein comprises the structure:

- [NH₂]-[effector domain]-[Cas9]-[COOH] or
  - [NH₂]-[Cas9]-[effector domain]-[COOH],
    
    wherein NH₂is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. FIG. 11 provides a schematic representation of a Cas9 protein fused to an effector domain (e.g., rAPOBEC1) in complex with sgRNA and bound to the target nucleic acid sequence.

In some embodiments, any of the fusion proteins provided herein may comprise one or more nuclear localization sequence (NLS). As used herein, a nuclear localization sequence refers to an amino acid sequence that promotes importation of a protein, for example any of the fusion proteins provided herein having an NLS, into the cell nucleus (e.g., via nuclear transport). Typically, an NLS comprises one or more short amino acid sequences of positively charged lysines or arginines exposed on the protein surface. Nuclear localization sequences are known in the art and would be apparent to the skilled artisan. For example nuclear localization sequences have been described in Kalderon D., et al., “A short amino acid sequence able to specify nuclear location”. Cell (1984) 39 (3 Pt 2): 499-509; Dingwall C., et al., “The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen”. J Cell Biol. (1988) 107 (3): 841-9; Makkerh J. P., et al., “Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids”. Curr Biol. (1996) 6 (8): 1025-7; and Ray M., et al., “Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules”. Bioconjug. Chem. (2015) 26 (6): 1004-7; the entire contents of each are incorporated by reference herein. Additional nuclear localization sequences are described, for example, in Plank et al., PCT/EP2000/011690, the entire contents are incorporated by reference herein. In some embodiments, a NLS comprises the amino acid sequence PKKKRKV (SEQ ID NO: 299) or MDSLLMNRRKFLYQFKNVRWAKGRRETYLC (SEQ ID NO: 300).

Exemplary features that may be present are localization sequences, such as nuclear localization sequences, cytoplasmic localization sequences, export sequences, such as nuclear export sequences, or other localization sequences, as well as sequence tags that are useful for solubilization, purification, or detection of the fusion proteins. Suitable localization signal sequences and sequences of protein tags are provided herein, and include, but are not limited to, biotin carboxylase carrier protein (BCCP) tags, myc-tags, calmodulin-tags, FLAG-tags, hemagglutinin (HA)-tags, polyhistidine tags, also referred to as histidine tags or His-tags, maltose binding protein (MBP)-tags, nus-tags, glutathione-S-transferase (GST)-tags, green fluorescent protein (GFP)-tags, thioredoxin-tags, S-tags, Softags (e.g., Softag 1, Softag 3), strep-tags, biotin ligase tags, FLASH tags, V5 tags, and SBP-tags. Additional suitable sequences will be apparent to those of skill in the art and are within the scope of this disclosure.

Any of the nuclear localization sequences provided herein may be fused to the fusion protein in any suitable localization. For example, to promote translocation of the fusion protein into a cell nucleus without compromising function of the fusion protein. In some embodiments, the NLS is fused N-terminal to the Cas9 protein of the fusion protein. In some embodiments, the NLS is fused C-terminal to the Cas9 protein of the fusion protein. In some embodiments, the NLS is fused N-terminal to the effector domain of the fusion protein. In some embodiments, the NLS is fused C-terminal to the effector domain of the fusion protein.

In some embodiments, the effector domain is a deaminase. For example, in some embodiments, the general architecture of exemplary Cas9 fusion proteins with a deaminase domain comprises the structure:

- [NH₂]-[NLS]-[Cas9]-[deaminase]-[COOH],
- [NH₂]-[NLS]-[deaminase]-[Cas9]-[COOH],
- [NH₂]-[Cas9]-[NLS]-[deaminase]-[COOH],
- [NH₂]-[deaminase]-[NLS]-[Cas9]-[COOH],
- [NH₂]-[deaminase]-[Cas9]-[NLS]-[COOH], or
- [NH₂]-[Cas9]-[deaminase]-[NLS]-[COOH],
  
  wherein NLS is a nuclear localization signal, NH₂is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, a linker is inserted between the Cas9 protein and the deaminase domain. In some embodiments, any of the “]-[” may be one or more linkers. In some embodiments, the NLS is located C-terminal of the deaminase and/or the Cas9 domain. In some embodiments, the NLS is located between the deaminase and the Cas9 domain. Additional features, such as sequence tags, may also be present.

One exemplary suitable type of effector domain includes cytosine deaminases, for example, of the APOBEC family. The apolipoprotein B mRNA-editing complex (APOBEC) family of cytosine deaminase enzymes encompasses eleven proteins that serve to initiate mutagenesis in a controlled and beneficial manner.²⁹One family member, activation-induced cytidine deaminase (AID), is responsible for the maturation of antibodies by converting cytosines in ssDNA to uracils in a transcription-dependent, strand-biased fashion.³⁰The apolipoprotein B editing complex 3 (APOBEC3) enzyme provides protection to human cells against a certain HIV-1 strain via the deamination of cytosines in reverse-transcribed viral SSDNA.³¹These proteins all require a Zn²⁺-coordinating motif (His-X-Glu-X_23-26-Pro-Cys-X_2-4-Cys; SEQ ID NO: 283) and bound water molecule for catalytic activity. The Glu residue acts to activate the water molecule to a zinc hydroxide for nucleophilic attack in the deamination reaction. Each family member preferentially deaminates at its own particular “hotspot,” ranging from WRC (W is A or T, R is A or G) for hAID, to TTC for hAPOBEC3F.³²A recent crystal structure of the catalytic domain of APOBEC3G revealed a secondary structure comprised of a five-stranded β-sheet core flanked by six α-helices, which is believed to be conserved across the entire family.³³The active center loops have been shown to be responsible for both ssDNA binding and in determining “hotspot” identity.³⁴Overexpression of these enzymes has been linked to genomic instability and cancer, thus highlighting the importance of sequence-specific targeting.³⁵

Some aspects of this disclosure provide a systematic series of fusions between Cas9 and deaminase domains, e.g., cytosine deaminase enzymes such as APOBEC enzymes, or adenosine deaminase enzymes such as ADAT enzymes, that has been generated in order to direct the enzymatic activities of these deaminases to a specific site in genomic DNA. The advantages of using Cas9 as the recognition agent are two-fold: (1) the sequence specificity of Cas9 can be easily altered by simply changing the sgRNA sequence; and (2) Cas9 binds to its target sequence by denaturing the dsDNA, resulting in a stretch of DNA that is single-stranded and therefore a viable substrate for the deaminase. It will be understood that other catalytic domains, or catalytic domains from other deaminases, can also be used to generate fusion proteins with Cas9, and that the disclosure is not limited in this regard.

Some aspects of this disclosure are based on the recognition that cas9: deaminase fusion proteins can efficiently deaminate nucleotides at positions 3-11 according to the numbering scheme in FIG. 11. It should be appreciated that a person of skill in the art will be able to design suitable guide RNAs to target the fusion proteins to a target sequence that comprises a nucleotide to be deaminated. Both PAM-dependent Cas9 proteins or Cas9 proteins that can target PAM-less target sequences as provided herein, can be employed for deamination of a target nucleotide.

Some exemplary suitable nucleic-acid editing domains, e.g., deaminases and deaminase domains, that can be fused to Cas9 domains according to aspects of this disclosure are provided below. Typically, deaminase require a Zn²⁺-coordinating motif (His-X-Glu-X_23-26-Pro-Cys-X_2-4-Cys; SEQ ID NO: 283) and bound water molecule for catalytic activity. The Glu residue acts to activate the water molecule to a zinc hydroxide for nucleophilic attack in the deamination reaction. It will be understood that, in some embodiments, the active domain of the respective sequence can be used, e.g., the domain without a localizing signal (nuclear localizing signal, without nuclear export signal, cytoplasmic localizing signal).

Human AID:

(SEQ ID NO: 263)

MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHV

ELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFC

EDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSR

QLRRILLPLYEVDDLRDAFRTLGL

(underline: nuclear localization signal; double underline:

nuclear export signal)

Mouse AID:

(SEQ ID NO: 264)

MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSCSLDFGHLRNKSGCHV

ELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTARLYFC

EDRKAEPEGLRRLHRAGVQIGIMTFKDYFYCWNTFVENRERTFKAWEGLHENSVRLTR

QLRRILLPLYEVDDLRDAFRMLGE

(underline: nuclear localization signal; double underline:

nuclear export signal)

Dog AID:

(SEQ ID NO: 265)

MDSLLMKQRKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSFSLDFGHLRNKSGCHV

ELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGYPNLSLRIFAARLYFC

EDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENREKTFKAWEGLHENSVRLSR

QLRRILLPLYEVDDLRDAFRTLGL

(underline: nuclear localization signal; double underline:

nuclear export signal)

Bovine AID:

(SEQ ID NO: 266)

MDSLLKKQRQFLYQFKNVRWAKGRHETYLCYVVKRRDSPTSFSLDFGHLRNKAGCHV

ELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGYPNLSLRIFTARLYFC

DKERKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLS

RQLRRILLPLYEVDDLRDAFRTLGL

(underline: nuclear localization signal; double underline:

nuclear export signal)

Mouse APOBEC-3:

(SEQ ID NO: 267)

MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPVSLH

HGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQIVRFLATHHN

LSLDIFSSRLYNVQDPETQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRP

WKRLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVEGRRMDPLSEE

EFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIR

SMELSQVTITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLW

QSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLRRIKESWGLQDLVN

DFGNLQLGPPMS

(italic: nucleic acid editing domain)

Rat APOBEC-3:

(SEQ ID NO: 268)

MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVSLH

HGVFKNKDNIHAEICFLYWFHDKVLKVLSPREEFKITWYMSWSPCFECAEQVLRFLATHHN

LSLDIFSSRLYNIRDPENQQNLCRLVQEGAQVAAMDLYEFKKCWKKFVDNGGRRFRPW

KKLLTNFRYQDSKLQEILRPCYIPVPSSSSSTLSNICLTKGLPETRFCVERRRVHLLSEEEF

YSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQHAEILFLDKIRSM

ELSQVIITCYLTWSPCPNCAWQLAAFKRDRPDLILHIYTSRLYFHWKRPFQKGLCSLWQSG

ILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLHRIKESWGLQDLVNDFG

NLQLGPPMS

(italic: nucleic acid editing domain)

Rhesus macaque APOBEC-3G:

(SEQ ID NO: 269)

MVEPMDPRTFVSNFNNRPILSGLNTVWLCCEVKTKDPSGPPLDAKIFQGKVYSKAKYHP

EM

RFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATFLAKDPKVTLTIFVARLYY

FWKPDYQQALRILCQKRGGPHATMKIMNYNEFQDCWNKFVDGRGKPFKPRNNLPKHY

TLLQATLGELLRHLMDPGTFTSNFNNKPWVSGQHETYLCYKVERLHNDTWVPLNQHR

GFLRNQAPNIHGFPKGRHAELCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISN

NEHVSLCIFAARIYDDQGRYQEGLRALHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQ

PWDGLDEHSQALSGRLRAI

(italic: nucleic acid editing domain; underline: cytoplasmic

localization signal)

Chimpanzee APOBEC-3G:

(SEQ ID NO: 270)

MKPHFRNPVERMYQDTESDNFYNRPILSHRNTVWLCYEVKTKGPSRPPLDAKIFRGQVY

SKLKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDVATFLAEDPKVTLTIF

VARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWN

NLPKYYILLHIMLGEILRHSMDPPTFTSNFNNELWVRGRHETYLCYEVERLHNDTWVLL

NQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLHQDYRVTCFTSWSPCFSCAQEM

AKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLAKAGAKISIMTYSEFKHCWDTFVDHQ

GCPFQPWDGLEEHSQALSGRLRAILQNQGN

(italic: nucleic acid editing domain; underline: cytoplasmic

localization signal)

Green monkey APOBEC-3G:

(SEQ ID NO: 271)

MNPQIRNMVEQMEPDIFVYYFNNRPILSGRNTVWLCYEVKTKDPSGPPLDANIFQGKLY

PEAKDHPEMKFLHWFRKWRQLHRDQEYEVTWYVSWSPCTRCANSVATFLAEDPKVTLTIF

VARLYYFWKPDYQQALRILCQERGGPHATMKIMNYNEFQHCWNEFVDGQGKPFKPRK

NLPKHYTLLHATLGELLRHVMDPGTFTSNFNNKPWVSGQRETYLCYKVERSHNDTWV

LLNQHRGFLRNQAPDRHGFPKGRHAELCFLDLIPFWKLDDQQYRVTCFTSWSPCFSCAQK

MAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLHRDGAKIAVMNYSEFEYCWDTFVD

RQGRPFQPWDGLDEHSQALSGRLRAI

(italic: nucleic acid editing domain; underline: cytoplasmic

localization signal)

Human APOBEC-3G:

(SEQ ID NO: 272)

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVY

SELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIF

VARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWN

NLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLL

NQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEM

AKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQ

GCPFQPWDGLDEHSQDLSGRLRAILQNQEN

(italic: nucleic acid editing domain; underline: cytoplasmic

localization signal)

Human APOBEC-3F:

(SEQ ID NO: 273)

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQV

YSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTIS

AARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFD

DNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVS

WKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLA

RHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEP

FKPWKGLKYNFLFLDSKLQEILE

(italic: nucleic acid editing domain)

Human APOBEC-3B:

(SEQ ID NO: 274)

MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQ

VYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTI

SAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKF

DENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMD

QHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGE

VRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVY

RQGCPFQPWDGLEEHSQALSGRLRAILQNQGN

(italic: nucleic acid editing domain)

Human APOBEC-3C:

(SEQ ID NO: 275)

MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRN

QVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTI

FTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKT

NFRLLKRRLRESLQ

(italic: nucleic acid editing domain)

Human APOBEC-3A:

(SEQ ID NO: 276)

MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQ

AKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTH

VRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWD

GLDEHSQALSGRLRAILQNQGN

(italic: nucleic acid editing domain)

Human APOBEC-3H:

(SEQ ID NO: 277)

MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFI

NEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQ

KGLRLLCGSQVPVEVMGFPKFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLE

RIKIPGVRAQGRYMDILCDAEV

(italic: nucleic acid editing domain)

Human APOBEC-3D:

(SEQ ID NO: 278)

MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGP

VLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVT

KFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVC

NEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLC

FTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSP

CPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVS

CWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ

(italic: nucleic acid editing domain)

Human APOBEC-1:

(SEQ ID NO: 279)

MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTT

NHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLF

WHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMM

LYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR

Mouse APOBEC-1:

(SEQ ID NO: 280)

MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSVWRHTSQNTSN

HVEVNFLEKFTTERYFRPNTRCSITWFLSWSPCGECSRAITEFLSRHPYVTLFIYIARLYH

HTDQRNRQGLRDLISSGVTIQIMTEQEYCYCWRNFVNYPPSNEAYWPRYPHLWVKLYV

LELYCIILGLPPCLKILRRKQPQLTFFTITLQTCHYQRIPPHLLWATGLK

Rat APOBEC-1:

(SEQ ID NO: 281)

MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNK

HVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHH

ADPRNRQGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVL

ELYCIILGLPPCLNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK

In some embodiments, fusion proteins as provided herein comprise the full-length amino acid of a effector domain, e.g., one of the sequences provided above. In other embodiments, however, fusion proteins as provided herein do not comprise a full-length sequence of a effector domain, but only a fragment thereof. For example, in some embodiments, a fusion protein provided herein comprises a Cas9 protein and a fragment of a effector domain, e.g., wherein the fragment comprises a effector domain. Exemplary amino acid sequences of effector domains are shown in the sequences above as italicized letters, and additional suitable sequences of such domains will be apparent to those of skill in the art.

Additional suitable nucleic-acid editing domain, e.g., deaminase domain sequences, that can be used according to aspects of this disclosure, e.g., that can be fused to a nuclease-inactive Cas9 protein, will be apparent to those of skill in the art based on this disclosure. In some embodiments, such additional domain sequences include deaminase domain sequences that are at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% similar to the sequences provided herein. Additional suitable Cas9 proteins, variants, and sequences will also be apparent to those of skill in the art. Examples of such additional suitable Cas9 proteins include, but are not limited to Cas9 proteins with the following mutations: D10A, D10A/D839A/H840A, and D10A/D839A/H840A/N863A (See, e.g., Prashant et al., CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. 2013; 31 (9): 833-838 the entire contents of which are incorporated herein by reference).

Additional suitable strategies for generating fusion proteins comprising a Cas9 protein and an effector domain, such as a DNA-editing domain, will be apparent to those of skill in the art based on this disclosure in combination with the general knowledge in the art. Suitable strategies for generating fusion proteins according to aspects of this disclosure using linkers or without the use of linkers will also be apparent to those of skill in the art in view of the instant disclosure and the knowledge in the art. For example, Gilbert et al., CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013; 154 (2): 442-51, showed that C-terminal fusions of Cas9 with VP64 using 2 NLS's as a linker (SPKKKRKVEAS, SEQ ID NO: 284), can be employed for transcriptional activation. Mali et al., Cas9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol. 2013; 31 (9): 833-8, reported that C-terminal fusions with VP64 without linker can be employed for transcriptional activation. And Maeder et al., CRISPR RNA-guided activation of endogenous human genes. Nat Methods. 2013; 10:977-979, reported that C-terminal fusions with VP64 using a Gly4Ser (SEQ ID NO: 5) linker can be used as transcriptional activators. Recently, dCas9-FokI nuclease fusions have successfully been generated and exhibit improved enzymatic specificity as compared to the parental Cas9 enzyme (In Guilinger J P, Thompson D B, Liu D R. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014; 32 (6): 577-82, and in Tsai S Q, Wyvekens N, Khayter C, Foden J A, Thapar V, Reyon D, Goodwin M J, Aryee M J, Joung J K. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat. Biotechnol. 2014; 32 (6): 569-76. PMID: 24770325 a SGSETPGTSESATPES (SEQ ID NO: 7) or a GGGGS (SEQ ID NO: 5) linker was used in FokI-dCas9 fusion proteins, respectively).

In some embodiments, the Cas9 fusion protein comprises: (i) Cas9 protein; and (ii) a transcriptional activator domain. In some embodiments, the transcriptional activator domain comprises a VPR. VPR is a VP64-SV40-P65-RTA tripartite activator. In some embodiments, VPR comprises a VP64 amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO: 292:

(SEQ ID NO: 292)

GAGGCCAGCGGTTCCGGACGGGCTGACGCATTGGACGATTTTGATCTGG

ATATGCTGGGAAGTGACGCCCTCGATGATTTTGACCTTGACATGCTTGG

TTCGGATGCCCTTGATGACTTTGACCTCGACATGCTCGGCAGTGACGCC

CTTGATGATTTCGACCTGGACATGCTGATTAACTCTAGATAG

In some embodiments. VPR comprises a VP64 amino acid sequence as set forth in SEQ ID NO: 293:

(SEQ ID NO: 293)

EASGSGRADALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDAL

DDFDLDMLINSR

In some embodiments. VPR comprises a VP64-SV40-P65-RTA amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO: 294:

(SEQ ID NO: 294)

TCGCCAGGGATCCGTCGACTTGACGCGTTGATATCAACAAGTTTGTACAAAAAAGCA

GGCTACAAAGAGGCCAGCGGTTCCGGACGGGCTGACGCATTGGACGATTTTGATCT

GGATATGCTGGGAAGTGACGCCCTCGATGATTTTGACCTTGACATGCTTGGTTCGGA

TGCCCTTGATGACTTTGACCTCGACATGCTCGGCAGTGACGCCCTTGATGATTTCGA

CCTGGACATGCTGATTAACTCTAGAAGTTCCGGATCTCCGAAAAAGAAACGCAAAG

TTGGTAGCCAGTACCTGCCCGACACCGACGACCGGCACCGGATCGAGGAAAAGCGG

AAGCGGACCTACGAGACATTCAAGAGCATCATGAAGAAGTCCCCCTTCAGCGGCCC

CACCGACCCTAGACCTCCACCTAGAAGAATCGCCGTGCCCAGCAGATCCAGCGCCA

GCGTGCCAAAACCTGCCCCCCAGCCTTACCCCTTCACCAGCAGCCTGAGCACCATCA

ACTACGACGAGTTCCCTACCATGGTGTTCCCCAGCGGCCAGATCTCTCAGGCCTCTG

CTCTGGCTCCAGCCCCTCCTCAGGTGCTGCCTCAGGCTCCTGCTCCTGCACCAGCTCC

AGCCATGGTGTCTGCACTGGCTCAGGCACCAGCACCCGTGCCTGTGCTGGCTCCTGG

ACCTCCACAGGCTGTGGCTCCACCAGCCCCTAAACCTACACAGGCCGGCGAGGGCA

CACTGTCTGAAGCTCTGCTGCAGCTGCAGTTCGACGACGAGGATCTGGGAGCCCTGC

TGGGAAACAGCACCGATCCTGCCGTGTTCACCGACCTGGCCAGCGTGGACAACAGC

GAGTTCCAGCAGCTGCTGAACCAGGGCATCCCTGTGGCCCCTCACACCACCGAGCCC

ATGCTGATGGAATACCCCGAGGCCATCACCCGGCTCGTGACAGGCGCTCAGAGGCC

TCCTGATCCAGCTCCTGCCCCTCTGGGAGCACCAGGCCTGCCTAATGGACTGCTGTC

TGGCGACGAGGACTTCAGCTCTATCGCCGATATGGATTTCTCAGCCTTGCTGGGCTC

TGGCAGCGGCAGCCGGGATTCCAGGGAAGGGATGTTTTTGCCGAAGCCTGAGGCCG

GCTCCGCTATTAGTGACGTGTTTGAGGGCCGCGAGGTGTGCCAGCCAAAACGAATCC

GGCCATTTCATCCTCCAGGAAGTCCATGGGCCAACCGCCCACTCCCCGCCAGCCTCG

CACCAACACCAACCGGTCCAGTACATGAGCCAGTCGGGTCACTGACCCCGGCACCA

GTCCCTCAGCCACTGGATCCAGCGCCCGCAGTGACTCCCGAGGCCAGTCACCTGTTG

GAGGATCCCGATGAAGAGACGAGCCAGGCTGTCAAAGCCCTTCGGGAGATGGCCGA

TACTGTGATTCCCCAGAAGGAAGAGGCTGCAATCTGTGGCCAAATGGACCTTTCCCA

TCCGCCCCCAAGGGGCCATCTGGATGAGCTGACAACCACACTTGAGTCCATGACCG

AGGATCTGAACCTGGACTCACCCCTGACCCCGGAATTGAACGAGATTCTGGATACCT

TCCTGAACGACGAGTGCCTCTTGCATGCCATGCATATCAGCACAGGACTGTCCATCT

TCGACACATCTCTGTTTTGA

In some embodiments, VPR comprises a VP64-SV40-P65-RTA amino acid sequence as set forth in SEQ ID NO: 295:

(SEQ ID NO: 295)

SPGIRRLDALISTSLYKKAGYKEASGSGRADALDDFDLDMLGSDALDDFD

LDMLGSDALDDFDLDMLGSDALDDFDLDMLINSRSSGSPKKKRKVGSQYL

PDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSA

SVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQ

APAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEA

LLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTT

EPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIAD

MDFSALLGSGSGSRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFH

PPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEAS

HLLEDPDEETSQAVKALREMADTVIPQKEEAAICGQMDLSHPPPRGHLDE

LTTTLESMTEDLNLDSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDT

SLF

Some aspects of this disclosure provide fusion proteins comprising a transcription activator. In some embodiments, the transcriptional activator is VPR. In some embodiments, the VPR comprises a wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR proteins provided herein include fragments of VPR and proteins homologous to a VPR or a VPR fragment. For example, in some embodiments, a VPR comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, a VPR comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 293 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, proteins comprising VPR or fragments of VPR or homologs of VPR or VPR fragments are referred to as “VPR variants.” A VPR variant shares homology to VPR, or a fragment thereof. For example a VPR variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR variant comprises a fragment of VPR, such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR comprises the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, the VPR comprises an amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO: 292.

In some embodiments, a VPR is a VP64-SV40-P65-RTA triple activator. In some embodiments, the VP64-SV40-P65-RTA comprises a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA proteins provided herein include fragments of VP64-SV40-P65-RTA and proteins homologous to a VP64-SV40-P65-RTA or a VP64-SV40-P65-RTA fragment. For example, in some embodiments, a VP64-SV40-P65-RTA comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, a VP64-SV40-P65-RTA comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 295 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, proteins comprising VP64-SV40-P65-RTA or fragments of VP64-SV40-P65-RTA or homologs of VP64-SV40-P65-RTA or VP64-SV40-P65-RTA fragments are referred to as “VP64-SV40-P65-RTA variants.” A VP64-SV40-P65-RTA variant shares homology to VP64-SV40-P65-RTA, or a fragment thereof. For example a VP64-SV40-P65-RTA variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA variant comprises a fragment of VP64-SV40-P65-RTA, such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA comprises the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA comprises an amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO: 294.

Some aspects of this disclosure provide fusion proteins comprising (i) a Cas9 protein; and (ii) a effector domain. In some aspects, the fusion proteins provided herein further include (iii) a DNA-binding protein, for example, a zinc-finger domain, a TALE, or a second Cas9 protein. Without wishing to be bound by any particular theory, fusing a DNA-binding protein (e.g., a second Cas9 protein) to a fusion protein comprising (i) a protein; and (ii) a effector domain may be useful for improving specificity of the fusion protein to a target nucleic acid sequence, or for improving specificity or binding affinity of the fusion protein to bind a target nucleic acid sequence that does not contain the canonical PAM (5′-NGG-3′) sequence. In some embodiments, the second Cas9 protein is any of the Cas9 proteins provided herein. In some embodiments, the second Cas9 protein is fused to the fusion protein N-terminal to the Cas9 protein. In some embodiments, the second Cas9 protein is fused to the fusion protein C-terminal to the Cas9 protein. In some embodiments, the Cas9 protein and the second Cas9 protein are fused via a linker.

Further provided herein are complexes comprising any of the fusion proteins provided herein, a first guide RNA bound to the Cas9 protein of the fusion protein, and a second guide RNA bound to the second Cas9 protein of the fusion protein. In some embodiments, the first guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a first target sequence and the second guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first guide RNA and/or the second guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the first guide RNA and the second guide RNA are different. In some embodiments, the first guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a first target sequence, and wherein the second guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first target sequence and the second target sequence are different. In some embodiments, the first target sequence and the second target sequence are DNA sequences. In some embodiments, the first target sequence and the second target sequence are in the genome of a mammal. In some embodiments, the first target sequence and the second target sequence are in the genome of a human. In some embodiments, the first target sequence is within 30 nucleotides of the second target sequence. In some embodiments, the 3′ end of the first target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′). In some embodiments, the 3′ end of the second target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′).

In some embodiments, the general architecture of exemplary Cas9 fusion proteins provided herein is of the structure:

- [NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];
- [NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];
- [NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];
- [NH₂]-[second Cas9 protein]-[effector or domain]-[Cas9]-[COOH];
- [NH₂]-[UGI]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];
- [NH₂]-[UGI]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];
- [NH₂]-[UGI]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];
- [NH₂]-[UGI]-[second Cas9 protein]-[effector domain]-[Cas9]-[COOH];
- [NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[UGI]-[COOH];
- [NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[UGI]-[COOH];
- [NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[UGI]-[COOH]; or
- [NH₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[UGI]-[COOH];
  
  wherein NH₂is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, the “]-[” used in the general architecture above indicates the presence of an optional linker sequence. In other examples, the general architecture of exemplary Cas9 fusion proteins provided herein is of the structure:
- [NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];
- [NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];
- [NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];
- [NH₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[COOH];
- [NH₂]-[UGI]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH],
- [NH₂]-[UGI]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];
- [NH₂]-[UGI]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];
- [NH₂]-[UGI]-[second Cas9 protein]-[effector domain]-[Cas9]-[COOH];
- [NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[UGI]-[COOH];
- [NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[UGI]-[COOH];
- [NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[UGI]-[COOH]; or
- [NH₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[UGI]-[COOH];
  
  wherein NH₂is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, the “-” used in the general architecture above indicates the presence of an optional linker sequence. In some embodiments, the second Cas9 is a dCas9 protein. In some examples, the general architecture of exemplary Cas9 fusion proteins provided herein comprises a structure as shown in FIG. 8. It should be appreciated that any of the proteins provided in any of the general architectures of exemplary Cas9 fusion proteins may be connected by one or more of the linkers provided herein. In some embodiments, the linkers are the same. In some embodiments, the linkers are different. In some embodiments, one or more of the proteins provided in any of the general architectures of exemplary Cas9 fusion proteins are not fused via a linker. In some embodiments, the fusion proteins further comprise a nuclear targeting sequence, for example a nuclear localization sequence. In some embodiments, fusion proteins provided herein further comprise a nuclear localization sequence (NLS). In some embodiments, the NLS is fused to the N-terminus of the fusion protein. In some embodiments, the NLS is fused to the C-terminus of the fusion protein. In some embodiments, the NLS is fused to the N-terminus of the second Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the second Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the effector domain. In some embodiments, the NLS is fused to the C-terminus of the effector domain. In some embodiments, the NLS is fused to the N-terminus of the UGI protein. In some embodiments, the NLS is fused to the C-terminus of the UGI protein. In some embodiments, the NLS is fused to the fusion protein via one or more linkers. In some embodiments, the NLS is fused to the fusion protein without a linker.

Uracil Glycosylase Inhibitor Fusion Proteins

Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein fused to a effector domain, e.g., a deaminase, and a uracil glycosylase inhibitor (UGI). In some embodiments, the fusion protein comprises the structure:

- [deaminase]-[optional linker sequence]-[Cas9]-[optional linker sequence]-[UGI];
- [deaminase]-[optional linker sequence]-[UGI]-[optional linker sequence]-[Cas9];
- [UGI]-[optional linker sequence]-[deaminase]-[optional linker sequence]-[Cas9];
- [UGI]-[optional linker sequence]-[Cas9]-[optional linker sequence]-[deaminase];
- [Cas9]-[optional linker sequence]-[deaminase]-[optional linker sequence]-[UGI]; or
- [Cas9]-[optional linker sequence]-[UGI]-[optional linker sequence]-[deaminase].
  
  In some embodiments, the fusion proteins do not comprise a linker sequence. In some embodiments, one or both of the optional linker sequences are present.

In some embodiments, the fusion protein further comprises a second Cas9 protein. For example, the second Cas9 protein may be any of the Cas9 proteins provided herein. In some embodiments, fusion protein comprises the structure:

- [deaminase]-[Cas9]-[UGI]; [deaminase]-[UGI]-[Cas9];
- [UGI]-[deaminase]-[Cas9];
- [UGI]-[Cas9]-[deaminase];
- [Cas9]-[deaminase]-[UGI];
- [Cas9]-[UGI]-[deaminase];
- [second Cas9]-[deaminase]-[Cas9]-[UGI];
- [second Cas9]-[deaminase]-[UGI]-[Cas9];
- [second Cas9]-[UGI]-[deaminase]-[Cas9];
- [second Cas9]-[UGI]-[Cas9]-[deaminase];
- [second Cas9]-[Cas9]-[deaminase]-[UGI];
- [second Cas9]-[Cas9]-[UGI]-[deaminase];
- [deaminase]-[second Cas9]-[Cas9]-[UGI];
- [deaminase]-[second Cas9]-[UGI]-[Cas9];
- [UGI]-[second Cas9]-[deaminase]-[Cas9];
- [UGI]-[second Cas9]-[Cas9]-[deaminase];
- [Cas9]-[second Cas9]-[deaminase]-[UGI];
- [Cas9]-[second Cas9]-[UGI]-[deaminase];
- [deaminase]-[Cas9]-[second Cas9]-[UGI];
- [deaminase]-[UGI]-[second Cas9]-[Cas9];
- [UGI]-[deaminase]-[second Cas9]-[Cas9];
- [UGI]-[Cas9]-[second Cas9]-[deaminase];
- [Cas9]-[deaminase]-[second Cas9]-[UGI];
- [Cas9]-[UGI]-[second Cas9]-[deaminase];
- [deaminase]-[Cas9]-[UGI]-[second Cas9];
- [deaminase]-[UGI]-[Cas9]-[second Cas9];
- [UGI]-[deaminase]-[Cas9]-[second Cas9];
- [UGI]-[Cas9]-[deaminase]-[second Cas9];
- [Cas9]-[deaminase]-[UGI]-[second Cas9]; or
- [Cas9]-[UGI]-[deaminase]-[second Cas9].
  
  In some embodiments, the “-” used in the general architecture above indicates the presence of an optional linker sequence. In some embodiments, the fusion proteins comprising a UGI further comprise a nuclear targeting sequence, for example a nuclear localization sequence. In some embodiments, fusion proteins provided herein further comprise a nuclear localization sequence (NLS). In some embodiments, the NLS is fused to the N-terminus of the fusion protein. In some embodiments, the NLS is fused to the C-terminus of the fusion protein. In some embodiments, the NLS is fused to the N-terminus of the UGI protein. In some embodiments, the NLS is fused to the C-terminus of the UGI protein. In some embodiments, the NLS is fused to the N-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the deaminase. In some embodiments, the NLS is fused to the C-terminus of the deaminase. In some embodiments, the NLS is fused to the N-terminus of the second Cas9. In some embodiments, the NLS is fused to the C-terminus of the second Cas9. In some embodiments, the NLS is fused to the fusion protein via one or more linkers. In some embodiments, the NLS is fused to the fusion protein without a linker.

In some embodiments, the UGI comprises a wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI proteins provided herein include fragments of UGI and proteins homologous to a UGI or a UGI fragment. For example, in some embodiments, a UGI comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 553. In some embodiments, a UGI comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 553 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 553. In some embodiments, proteins comprising UGI or fragments of UGI or homologs of UGI or UGI fragments are referred to as “UGI variants.” A UGI variant shares homology to UGI, or a fragment thereof. For example a UGI variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI variant comprises a fragment of UGI, such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI comprises the following amino acid sequence:

>sp|P14739|UNGI_BPPB2 Uracil-DNA glycosylase

inhibitor

(SEQ ID NO: 553)

MTNLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDILVHTAYDES

TDENVMLLTSDAPEYKPWALVIQDSNGENKIKML

Suitable UGI protein and nucleotide sequences are provided herein and additional suitable UGI sequences are known to those in the art, and include, for example, those published in Wang et al., Uracil-DNA glycosylase inhibitor gene of bacteriophage PBS2 encodes a binding protein specific for uracil-DNA glycosylase. J. Biol. Chem. 264:1163-1171 (1989); Lundquist et al., Site-directed mutagenesis and characterization of uracil-DNA glycosylase inhibitor protein. Role of specific carboxylic amino acids in complex formation with Escherichia coli uracil-DNA glycosylase. J. Biol. Chem. 272:21408-21419 (1997); Ravishankar et al., X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG. Nucleic Acids Res. 26:4880-4887 (1998); and Putnam et al., Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J. Mol. Biol. 287:331-346 (1999), the entire contents of each are incorporated herein by reference.

It should be appreciated that additional proteins may be uracil glycosylase inhibitors. For example, other proteins that are capable of inhibiting (e.g., sterically blocking) a uracil-DNA glycosylase base-excision repair enzyme are within the scope of this disclosure. In some embodiments, a uracil glycosylase inhibitor is a protein that binds DNA. In some embodiments, a uracil glycosylase inhibitor is a protein that binds single-stranded DNA. For example, a uracil glycosylase inhibitor may be a Erwinia tasmaniensis single-stranded binding protein. In some embodiments, the single-stranded binding protein comprises the amino acid sequence (SEQ ID NO: 303). In some embodiments, a uracil glycosylase inhibitor is a protein that binds uracil. In some embodiments, a uracil glycosylase inhibitor is a protein that binds uracil in DNA. In some embodiments, a uracil glycosylase inhibitor is a catalytically inactive uracil DNA-glycosylase protein. In some embodiments, a uracil glycosylase inhibitor is a catalytically inactive uracil DNA-glycosylase protein that does not excise uracil from the DNA. For example, a uracil glycosylase inhibitor is a UdgX. In some embodiments, the UdgX comprises the amino acid sequence (SEQ ID NO: 304). As another example, a uracil glycosylase inhibitor is a catalytically inactive UDG. In some embodiments, a catalytically inactive UDG comprises the amino acid sequence (SEQ ID NO: 305). It should be appreciated that other uracil glycosylase inhibitors would be apparent to the skilled artisan and are within the scope of this disclosure.

Erwinia tasmaniensis SSB (themostable single-stranded DNA binding protein)

(SEQ ID NO: 303)

MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKQTGETKEKTEWHR

VVLFGKLAEVAGEYLRKGSQVYIEGALQTRKWTDQAGVEKYTTEVVVNVGGTMQML

GGRSQGGGASAGGQNGGSNNGWGQPQQPQGGNQFSGGAQQQARPQQQPQQNNAPAN

NEPPIDFDDDIP

UdgX (binds to Uracil in DNA but does not excise)

(SEQ ID NO: 304)

MAGAQDFVPHTADLAELAAAAGECRGCGLYRDATQAVFGAGGRSARIMMIGEQPGDK

EDLAGLPFVGPAGRLLDRALEAADIDRDALYVTNAVKHFKFTRAAGGKRRIHKTPSRTE

VVACRPWLIAEMTSVEPDVVVLLGATAAKALLGNDFRVTQHRGEVLHVDDVPGDPAL

VATVHPSSLLRGPKEERESAFAGLVDDLRVAADVRP

UDG (catalytically inactive human UDG, binds to Uracil in DNA but does not excise)

(SEQ ID NO: 305)

MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGT

PPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVA

EERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQEPYHGPNQAHGLCFSVQRPVPPPPS

LENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTD

AVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFS

KTNELLQKSGKKPIDWKEL

High Fidelity Cas9

Some aspects of the disclosure provide high fidelity Cas9 proteins. In some embodiments, high fidelity Cas9 proteins have decreased electrostatic interactions between the Cas9 protein and a sugar-phosphate backbone of a DNA, as compared to a wild-type Cas9 domain. In some embodiments, any of the Cas9 proteins provided herein comprise one or more mutations that decrease the association between the Cas9 protein and a sugar-phosphate backbone of a DNA. In some embodiments, any of the Cas9 proteins provided herein comprise one or more mutations that decrease the association between the Cas9 protein and a sugar-phosphate backbone of a DNA by at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95%. In some embodiments, any of the Cas9 proteins provided herein comprise one or more of a N497X, a R661X, a Q695X, and/or a Q926X mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, any of the Cas9 proteins provided herein comprise one or more of a N497A, a R661A, a Q695A, and/or a Q926A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises the amino acid sequence as set forth in SEQ ID NO: 306. High fidelity Cas9 proteins have been described in the art and would be apparent to the skilled artisan. For example, high fidelity Cas9 proteins have been described in Kleinstiver, B. P., et al. “High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.” Nature 529, 490-495 (2016); and Slaymaker, I. M., et al. “Rationally engineered Cas9 nucleases with improved specificity.” Science 351, 84-88 (2015); the entire contents of each are incorporated herein by reference. It should be appreciated that, based on the present disclosure and knowledge in the art, that mutations in any Cas9 protein may be generated to make high fidelity Cas9 proteins that have decreased electrostatic interactions between the Cas9 protein and a sugar-phosphate backbone of a DNA, as compared to a wild-type Cas9 domain.

Cas9 domain where mutations relative to Cas9 of SEQ ID NO: 9 are shown in bold and underlines.

(SEQ ID NO: 306)

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA

EATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIF

GNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNS

DVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFG

NLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSD

AILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGY

AGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGEL

HAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEE

VVDKGASAQSFIERMTAFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPA

FLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLL

KIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTG

WGALSRKLINGIRDKQSGKTILDFLKSDGFANRNFMALIHDDSLTFKEDIQKAQVSGQG

DSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKN

SRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD

YDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLIT

QRKFDNLTKAERGGLSELDKAGFIKRQLVETRAITKHVAQILDSRMNTKYDENDKLIRE

VKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYG

DYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEI

VWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKK

YGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKE

VKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGS

PEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Cas9 Proteins with Reduced PAM Exclusivity

Some aspects of the disclosure provide Cas9 proteins that have different PAM specificities. Typically, Cas9 proteins, such as Cas9 from S. pyogenes (spCas9), require a canonical NGG PAM sequence to bind a particular nucleic acid region. This may limit the ability to of the Cas9 protein to bind to a particular nucleotide sequence within a genome. Accordingly, in some embodiments, any of the Cas proteins provided herein may be capable of binding a nucleotide sequence that does not contain a canonical (e.g., NGG) PAM sequence. For example, Cas9 proteins that bind non-canonical PAM sequences have been described in Kleinstiver, B. P., et al., “Engineered CRISPR-Cas9 nucleases with altered PAM specificities” Nature 523, 481-485 (2015); and Kleinstiver, B. P., et al., “Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition” Nature Biotechnology 33, 1293-1298 (2015); the entire contents of each are hereby incorporated by reference.

In some embodiments, the Cas9 protein is a Cas9 protein from Staphylococcus aureus (SaCas9). In some embodiments, the SaCas9 protein is a nuclease active SaCas9, a nuclease inactive SaCas9 (SaCas9d), or a SaCas9 nickase (SaCas9n). In some embodiments, the SaCas9 comprises the amino acid sequence SEQ ID NO: 307. In some embodiments, the SaCas9 comprises a N579X mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 9-262, wherein X is any amino acid except for N. In some embodiments, the SaCas9 comprises a N579A mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SaCas9 protein, the SaCas9d protein, or the SaCas9n protein can bind to a nucleic acid sequence having a non-canonical PAM. In some embodiments, the SaCas9 protein, the SaCas9d protein, or the SaCas9n protein can bind to a nucleic acid sequence having a NNGRRT PAM sequence. In some embodiments, the SaCas9 protein comprises one or more of a E781X, N967X, or R1014X mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SaCas9 protein comprises one or more of a E781K, N967K, or R1014H mutation of SEQ ID NO: 307, or one or more corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SaCas9 protein comprises a E781K, a N967K, and a R1014H mutation of SEQ ID NO: 307, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. It should be appreciated that these mutations may be combined with any of the other mutations provided herein

In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises an amino acid sequence that is at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to any one of SEQ ID NOs: 307-309. In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises the amino acid sequence of any one of SEQ ID NOs: 307-309. In some embodiments, the Cas9 protein of any of the fusion proteins provided herein consists of the amino acid sequence of any one of SEQ ID NOs: 307-309.

Exemplary SaCas9 Sequence

(SEQ ID NO: 307)

KRNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRRRR

HRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRGVHN

VNEVEEDTGNELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSINRFKTSDYVKE

AKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWYEMLMGHC

TYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYYEKFQIIENVFKQKKKPTL

KQIAKEILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIY

QSSEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINLILDELWHTNDNQIAIFNR

LKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKKYGLPNDIIIELAREKN

SKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKLHDMQEGKCLYSLEAIPL

EDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEENSKKGNRTPFQYLSSSDSKISYETF

KKHILNLAKGKGRISKTKKEYLLEERDINRFSVQKDFINRNLVDTRYATRGLMNLLRSYF

RVNNLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHAEDALIIANADFIFKEWKKLD

KAKKVMENQMFEEKQAESMPEIETEQEYKEIFITPHQIKHIKDFKDYKYSHRVDKKPNR

ELINDTLYSTRKDDKGNTLIVNNLNGLYDKDNDKLKKLINKSPEKLLMYHHDPQTYQK

LKLIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDY

PNSRNKVVKLSLKPYRFDVYLDNGVYKFVTVKNLDVIKKENYYEVNSKCYEEAKKLK

KISNQAEFIASFYNNDLIKINGELYRVIGVNNDLLNRIEVNMIDITYREYLENMNDKRPPR

IIKTIASKTQSIKKYSTDILGNLYEVKSKKHPQIIKKG

Residue N579 of SEQ ID NO: 307, which is underlined and in bold, may be mutated (e.g., to a A579) to yield a SaCas9 nickase.

Exemplary SaCas9n sequence

(SEQ ID NO: 308)

KRNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRRRR

HRIQR VKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRGVHN

VNEVEEDTGNELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSINRFKTSDYVKE

AKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWYEMLMGHC

TYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYYEKFQIIENVFKQKKKPTL

KQIAKEILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIY

QSSEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINLILDELWHTNDNQIAIFNR

LKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKKYGLPNDIIIELAREKN

SKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKLHDMQEGKCLYSLEAIPL

EDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEEASKKGNRTPFQYLSSSDSKISYETF

KKHILNLAKGKGRISKTKKEYLLEERDINRFSVQKDFINRNLVDTRYATRGLMNLLRSYF

RVNNLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHAEDALIIANADFIFKEWKKLD

KAKKVMENQMFEEKQAESMPEIETEQEYKEIFITPHQIKHIKDFKDYKYSHRVDKKPNR

ELINDTLYSTRKDDKGNTLIVNNLNGLYDKDNDKLKKLINKSPEKLLMYHHDPQTYQK

LKLIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDY

PNSRNKVVKLSLKPYRFDVYLDNGVYKFVTVKNLDVIKKENYYEVNSKCYEEAKKLK

KISNQAEFIASFYNNDLIKINGELYRVIGVNNDLLNRIEVNMIDITYREYLENMNDKRPPR

IIKTIASKTQSIKKYSTDILGNLYEVKSKKHPQIIKKG

Residue A579 of SEQ ID NO: 308, which can be mutated from N579 of SEQ ID NO: 307 to yield a SaCas9 nickase, is underlined and in bold.

Exemplary SaKKH Cas9

(SEQ ID NO: 309)

KRNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRRRR

HRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRGVHN

VNEVEEDTGNELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSINRFKTSDYVKE

AKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWYEMLMGHC

TYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYYEKFQIIENVFKQKKKPTL

KQIAKEILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIY

QSSEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINLILDELWHTNDNQIAIFNR

LKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKKYGLPNDIIIELAREKN

SKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKLHDMQEGKCLYSLEAIPL

EDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEEASKKGNRTPFQYLSSSDSKISYETF

KKHILNLAKGKGRISKTKKEYLLEERDINRFSVQKDFINRNLVDTRYATRGLMNLLRSYF

RVNNLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHAEDALIIANADFIFKEWKKLD

KAKKVMENQMFEEKQAESMPEIETEQEYKEIFITPHQIKHIKDFKDYKYSHRVDKKPNR

K
LINDTLYSTRKDDKGNTLIVNNLNGLYDKDNDKLKKLINKSPEKLLMYHHDPQTYQK

LKLIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDY

PNSRNKVVKLSLKPYRFDVYLDNGVYKFVTVKNLDVIKKENYYEVNSKCYEEAKKLK

KISNQAEFIASFYKNDLIKINGELYRVIGVNNDLLNRIEVNMIDITYREYLENMNDKRPPH

IIKTIASKTQSIKKYSTDILGNLYEVKSKKHPQIIKKG

Residue A579 of SEQ ID NO: 309, which can be mutated from N579 of SEQ ID NO: 307 to yield a SaCas9 nickase, is underlined and in bold. Residues K781, K967, and H1014 of SEQ ID NO: 309, which can be mutated from E781, N967, and R1014 of SEQ ID NO: 307 to yield a SaKKH Cas9 are underlined and in italics.

In some embodiments, the Cas9 protein is a Cas9 protein from Streptococcus pyogenes (SpCas9). In some embodiments, the SpCas9 protein is a nuclease active SpCas9, a nuclease inactive SpCas9 (SpCas9d), or a SpCas9 nickase (SpCas9n). In some embodiments, the SpCas9 comprises the amino acid sequence SEQ ID NO: 9. In some embodiments, the SpCas9 comprises a D10X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid except for D. In some embodiments, the SpCas9 comprises a D10A mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein, the SpCas9d protein, or the SpCas9n protein can bind to a nucleic acid sequence having a non-canonical PAM. In some embodiments, the SpCas9 protein, the SpCas9d protein, or the SpCas9n protein can bind to a nucleic acid sequence having a NGG, a NGA, or a NGCG PAM sequence. In some embodiments, the SpCas9 protein comprises one or more of a D1135X, R1335X, and T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a D1135E, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a D1135E, a R1335Q, and a T1335R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises one or more of a D1135X, R1335X, and T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a D1135V, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a D1135V, a R1335Q, and a T1337R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises one or more of a D1135X, G1218X, R1335X, and T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a D1135V, G1218R, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a D1135V, a G1218R, a R1335Q, and a T1337R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. It should be appreciated that these mutations may be combined with any of the other mutations provided herein

In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises an amino acid sequence that is at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to any one of SEQ ID NOs: 9, 310-313. In some embodiments, the Cas9 domain of any of the fusion proteins provided herein comprises the amino acid sequence of any one of SEQ ID NOs: 9, 310-313. In some embodiments, the Cas9 domain of any of the fusion proteins provided herein consists of the amino acid sequence of any one of SEQ ID NOs: 9, 310-313.

Exemplary SpCas9

(SEQ ID NO: 9)

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA

EATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIF

GNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNS

DVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFG

NLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSD

AILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGY

AGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGEL

HAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEE

VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPA

FLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLL

KIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTG

WGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQG

DSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKN

SRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD

YDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLIT

QRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIRE

VKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYG

DYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEI

VWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKK

YGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKE

VKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGS

PEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENI

IHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Exemplary SpCas9n

(SEQ ID NO: 310)

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEA

TRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGN

IVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDV

DKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI

ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL

LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAG

YIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAI

LRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVV

DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLS

GEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII

KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG

RLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL

HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRE

RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDV

DHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRK

FDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVI

TLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYK

VYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWD

KGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGG

FDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKK

DLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPED

NEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHL

FTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Exemplary SpEQR Cas9

(SEQ ID NO: 311)

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEA

TRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGN

IVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDV

DKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI

ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL

LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAG

YIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAI

LRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVV

DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLS

GEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII

KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG

RLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL

HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRE

RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDV

DHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRK

FDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVI

TLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYK

VYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWD

KGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGG

FESPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKD

LIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNE

QKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFT

LTNLGAPAAFKYFDTTIDRKQYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Residues E1134, Q1334, and R1336 of SEQ ID NO: 311, which can be mutated from D1134. R1334, and T1336 of SEQ ID NO: 9 to yield a SpEQR Cas9, are underlined and in bold.

Exemplary SpVQR Cas9

(SEQ ID NO: 312)

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEA

TRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGN

IVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDV

DKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI

ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL

LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAG

YIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAI

LRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVV

DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLS

GEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII

KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG

RLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL

HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRE

RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDV

DHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRK

FDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVI

TLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYK

VYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWD

KGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGG

FVSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKK

DLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPED

NEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHL

FTLTNLGAPAAFKYFDTTIDRKQYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Residues V1134, Q1334, and R1336 of SEQ ID NO: 312, which can be mutated from D1134. R1334, and T1336 of SEQ ID NO: 9 to yield a SpVQR Cas9, are underlined and in bold.

Exemplary SpVRER Cas9

(SEQ ID NO: 313)

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEA

TRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGN

IVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDV

DKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI

ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL

LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAG

YIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAI

LRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVV

DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLS

GEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII

KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG

RLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL

HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRE

RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDV

DHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRK

FDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVI

TLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYK

VYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWD

KGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGG

FVSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKK

DLIIKLPKYSLFELENGRKRMLASARELQKGNELALPSKYVNFLYLASHYEKLKGSPED

NEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHL

FTLTNLGAPAAFKYFDTTIDRKEYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD

Residues V1134, R1217, Q1334, and R1336 of SEQ ID NO: 313, which can be mutated from D1134, G1217, R1334, and T1336 of SEQ ID NO: 9 to yield a SpVRER Cas9, are underlined and in bold.

Cas9 Complexes with Guide RNAs

Some aspects of this disclosure provide complexes comprising a Cas9 protein or a Cas9 fusion protein as provided herein, and a guide RNA bound to the Cas9 protein or the Cas9 fusion protein. In some embodiments, the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence. In some embodiments, the guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a target sequence. In some embodiments, the target sequence is a DNA sequence. In some embodiments, the target sequence is a sequence in the genome of a mammal. In some embodiments, the target sequence is a sequence in the genome of a human. In some embodiments, the 3′ end of the target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′).

Some aspects of the disclosure provide complexes comprising a first guide RNA bound to a Cas9 protein of a fusion protein, and a second guide RNA bound to a second Cas9 protein of the fusion protein. In some embodiments, the first guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a first target sequence and the second guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first guide RNA and/or the second guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the first guide RNA and the second guide RNA are different. In some embodiments, the first guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a first target sequence and wherein the second guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a second target sequence.

In some embodiments, first target sequence and the second target sequence are different. In some embodiments, the first target sequence and the second target sequence are DNA sequences. In some embodiments, the first target sequence and the second target sequence are in the genome of a mammal. In some embodiments, the first target sequence and the second target sequence are in the genome of a human. In some embodiments, the first target sequence is within at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 150, or 200 nucleotides of the second target sequence. In some embodiments, the 3′-end of the first target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′). In some embodiments, the 3′-end of the second target sequence is not immediately adjacent to the canonical PAM sequence (5′-NGG-3′).

Methods of Using Cas9 Fusion Proteins

In some embodiments, the target DNA sequence comprises a sequence associated with a disease or disorder. In some embodiments, the target DNA sequence comprises a point mutation associated with a disease or disorder. In some embodiments, the activity of the Cas9 protein, the Cas9 fusion protein, or the complex results in a correction of the point mutation. In some embodiments, the target DNA sequence comprises a T→C point mutation associated with a disease or disorder, and wherein the deamination of the mutant C base results in a sequence that is not associated with a disease or disorder. In some embodiments, the target DNA sequence encodes a protein and wherein the point mutation is in a codon and results in a change in the amino acid encoded by the mutant codon as compared to the wild-type codon. In some embodiments, the deamination of the mutant C results in a change of the amino acid encoded by the mutant codon. In some embodiments, the deamination of the mutant C results in the codon encoding the wild-type amino acid. In some embodiments, the contacting is in vivo in a subject. In some embodiments, the subject has or has been diagnosed with a disease or disorder. In some embodiments, the disease or disorder is cystic fibrosis, phenylketonuria, epidermolytic hyperkeratosis (EHK), Charcot-Marie-Toot disease type 4J, neuroblastoma (NB), von Willebrand disease (vWD), myotonia congenital, hereditary renal amyloidosis, dilated cardiomyopathy (DCM), hereditary lymphedema, familial Alzheimer's disease, HIV, Prion disease, chronic infantile neurologic cutaneous articular syndrome (CINCA), desmin-related myopathy (DRM), a neoplastic disease associated with a mutant PI3KCA protein, a mutant CTNNB1 protein, a mutant HRAS protein, or a mutant p53 protein.

Some embodiments provide methods for using the Cas9 DNA editing fusion proteins provided herein. In some embodiments, the fusion protein is used to introduce a point mutation into a nucleic acid by deaminating a target nucleobase, e.g., a C residue. In some embodiments, the deamination of the target nucleobase results in the correction of a genetic defect, e.g., in the correction of a point mutation that leads to a loss of function in a gene product. In some embodiments, the genetic defect is associated with a disease or disorder, e.g., a lysosomal storage disorder or a metabolic disease, such as, for example, type I diabetes. In some embodiments, the methods provided herein are used to introduce a deactivating point mutation into a gene or allele that encodes a gene product that is associated with a disease or disorder. For example, in some embodiments, methods are provided herein that employ a Cas9 DNA editing fusion protein to introduce a deactivating point mutation into an oncogene (e.g., in the treatment of a proliferative disease). A deactivating mutation may, in some embodiments, generate a premature stop codon in a coding sequence, which results in the expression of a truncated gene product, e.g., a truncated protein lacking the function of the full-length protein.

In some embodiments, the purpose of the methods provide herein is to restore the function of a dysfunctional gene via genome editing. The Cas9 deaminase fusion proteins provided herein can be validated for gene editing-based human therapeutics in vitro, e.g., by correcting a disease-associated mutation in human cell culture. It will be understood by the skilled artisan that the fusion proteins provided herein, e.g., the fusion proteins comprising a Cas9 domain and a nucleic acid deaminase domain can be used to correct any single point T->C or A->G mutation. In the first case, deamination of the mutant C back to U corrects the mutation, and in the latter case, deamination of the C that is base-paired with the mutant G, followed by a round of replication, corrects the mutation.

An exemplary disease-relevant mutation that can be corrected by the provided fusion proteins in vitro or in vivo is the H1047R (A3140G) polymorphism in the PI3KCA protein. The phosphoinositide-3-kinase, catalytic alpha subunit (PI3KCA) protein acts to phosphorylate the 3-OH group of the inositol ring of phosphatidylinositol. The PI3KCA gene has been found to be mutated in many different carcinomas, and thus it is considered to be a potent oncogene.⁵⁰In fact, the A3140G mutation is present in several NCI-60 cancer cell lines, such as, for example, the HCT116, SKOV3, and T47D cell lines, which are readily available from the American Type Culture Collection (ATCC).⁵¹

In some embodiments, a cell carrying a mutation to be corrected, e.g., a cell carrying a point mutation, e.g., an A3140G point mutation in exon 20 of the PI3KCA gene, resulting in a H1047R substitution in the PI3KCA protein, is contacted with an expression construct encoding a Cas9 deaminase fusion protein and an appropriately designed sgRNA targeting the fusion protein to the respective mutation site in the encoding PI3KCA gene. Control experiments can be performed where the sgRNAs are designed to target the fusion enzymes to non-C residues that are within the PI3KCA gene. Genomic DNA of the treated cells can be extracted, and the relevant sequence of the PI3KCA genes PCR amplified and sequenced to assess the activities of the fusion proteins in human cell culture.

It will be understood that the example of correcting point mutations in PI3KCA is provided for illustration purposes and is not meant to limit the instant disclosure. The skilled artisan will understand that the instantly disclosed DNA-editing fusion proteins can be used to correct other point mutations and mutations associated with other cancers and with diseases other than cancer including other proliferative diseases.

The successful correction of point mutations in disease-associated genes and alleles opens up new strategies for gene correction with applications in therapeutics and basic research. Site-specific single-base modification systems like the disclosed fusions of Cas9 and deaminase enzymes or domains also have applications in “reverse” gene therapy, where certain gene functions are purposely suppressed or abolished. In these cases, site-specifically mutating Trp (TGG), Gln (CAA and CAG), or Arg (CGA) residues to premature stop codons (TAA, TAG, TGA) can be used to abolish protein function in vitro, ex vivo, or in vivo.

The instant disclosure provides methods for the treatment of a subject diagnosed with a disease associated with or caused by a point mutation that can be corrected by a Cas9 DNA editing fusion protein provided herein. For example, in some embodiments, a method is provided that comprises administering to a subject having such a disease, e.g., a cancer associated with a PI3KCA point mutation as described above, an effective amount of a Cas9 deaminase fusion protein that corrects the point mutation or introduces a deactivating mutation into the disease-associated gene. In some embodiments, the disease is a proliferative disease. In some embodiments, the disease is a genetic disease. In some embodiments, the disease is a neoplastic disease. In some embodiments, the disease is a metabolic disease. In some embodiments, the disease is a lysosomal storage disease. Other diseases that can be treated by correcting a point mutation or introducing a deactivating mutation into a disease-associated gene will be known to those of skill in the art, and the disclosure is not limited in this respect.

The instant disclosure provides methods for the treatment of additional diseases or disorders, e.g., diseases or disorders that are associated or caused by a point mutation that can be corrected by deaminase-mediated gene editing. Some such diseases are described herein, and additional suitable diseases that can be treated with the strategies and fusion proteins provided herein will be apparent to those of skill in the art based on the instant disclosure. Exemplary suitable diseases and disorders are listed below. It will be understood that the numbering of the specific positions or residues in the respective sequences depends on the particular protein and numbering scheme used. Numbering might be different, e.g., in precursors of a mature protein and the mature protein itself, and differences in sequences from species to species may affect numbering. One of skill in the art will be able to identify the respective residue in any homologous protein and in the respective encoding nucleic acid by methods well known in the art, e.g., by sequence alignment and determination of homologous residues. Exemplary suitable diseases and disorders include, without limitation, cystic fibrosis (see, e.g., Schwank et al., Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell. 2013; 13:653-658; and Wu et. al., Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell stem cell. 2013; 13:659-662, neither of which uses a deaminase fusion protein to correct the genetic defect); phenylketonuria—e.g., phenylalanine to serine mutation at position 835 (mouse) or 240 (human) or a homologous residue in phenylalanine hydroxylase gene (T>C mutation)—see, e.g., McDonald et al., Genomics. 1997; 39:402-405; Bernard-Soulier syndrome (BSS)—e.g., phenylalanine to serine mutation at position 55 or a homologous residue, or cysteine to arginine at residue 24 or a homologous residue in the platelet membrane glycoprotein IX (T>C mutation)—see, e.g., Noris et al., British Journal of Haematology. 1997; 97:312-320, and Ali et al., Hematol. 2014; 93:381-384; epidermolytic hyperkeratosis (EHK)—e.g., leucine to proline mutation at position 160 or 161 (if counting the initiator methionine) or a homologous residue in keratin 1 (T>C mutation)—see, e.g., Chipev et al., Cell. 1992; 70:821-828, see also accession number P04264 in the UNIPROT database at www[dot]uniprot [dot]org; chronic obstructive pulmonary disease (COPD)—e.g., leucine to proline mutation at position 54 or 55 (if counting the initiator methionine) or a homologous residue in the processed form of a1-antitrypsin or residue 78 in the unprocessed form or a homologous residue (T>C mutation)—see, e.g., Poller et al., Genomics. 1993; 17:740-743, see also accession number P01011 in the UNIPROT database; Charcot-Marie-Toot disease type 4J—e.g., isoleucine to threonine mutation at position 41 or a homologous residue in FIG. 4 (T>C mutation)—see, e.g., Lenk et al., PLOS Genetics. 2011; 7: e1002104; neuroblastoma (NB)—e.g., leucine to proline mutation at position 197 or a homologous residue in Caspase-9 (T>C mutation)—see, e.g., Kundu et al., 3 Biotech. 2013, 3:225-234; von Willebrand disease (vWD)—e.g., cysteine to arginine mutation at position 509 or a homologous residue in the processed form of von Willebrand factor, or at position 1272 or a homologous residue in the unprocessed form of von Willebrand factor (T>C mutation)—see, e.g., Lavergne et al., Br. J. Haematol. 1992, see also accession number P04275 in the UNIPROT database; 82:66-72; myotonia congenital—e.g., cysteine to arginine mutation at position 277 or a homologous residue in the muscle chloride channel gene CLCN1 (T>C mutation)—see, e.g., Weinberger et al., The J. of Physiology. 2012; 590:3449-3464; hereditary renal amyloidosis—e.g., stop codon to arginine mutation at position 78 or a homologous residue in the processed form of apolipoprotein AII or at position 101 or a homologous residue in the unprocessed form (T>C mutation)—see, e.g., Yazaki et al., Kidney Int. 2003; 64:11-16; dilated cardiomyopathy (DCM)—e.g., tryptophan to Arginine mutation at position 148 or a homologous residue in the FOXD4 gene (T>C mutation), see, e.g., Minoretti et. al., Int. J. of Mol. Med. 2007; 19:369-372; hereditary lymphedema—e.g., histidine to arginine mutation at position 1035 or a homologous residue in VEGFR3 tyrosine kinase (A>G mutation), scc, e.g., Irrthum et al., Am. J. Hum. Genet. 2000; 67:295-301; familial Alzheimer's disease—e.g., isoleucine to valine mutation at position 143 or a homologous residue in presenilin1 (A>G mutation), see, e.g., Gallo et. al., J. Alzheimer's disease. 2011; 25:425-431; Prion disease—e.g., methionine to valine mutation at position 129 or a homologous residue in prion protein (A>G mutation)—see, e.g., Lewis et. al., J. of General Virology. 2006; 87:2443-2449; chronic infantile neurologic cutaneous articular syndrome (CINCA)—e.g., Tyrosine to Cysteine mutation at position 570 or a homologous residue in cryopyrin (A>G mutation)—see, e.g., Fujisawa et. al. Blood. 2007; 109:2903-2911; and desmin-related myopathy (DRM)—e.g., arginine to glycine mutation at position 120 or a homologous residue in &B crystallin (A>G mutation)—see, e.g., Kumar et al., J. Biol. Chem. 1999; 274:24137-24141. The entire contents of all references and database entries is incorporated herein by reference.

The instant disclosure provides lists of genes comprising pathogenic T>C or A>G mutations, which may be corrected using any of the Cas9 fusion proteins provided herein. Provided herein, are the names of these genes, their respective SEQ ID NOs, their gene IDs, and sequences flanking the mutation site. See Tables 4 and 5. Without wishing to be bound by any particular theory, the mutations provided in Tables 4 and 5 may be corrected using the Cas9 fusions provided herein, which are able to bind to target sequences lacking the canonical PAM sequence. In some embodiments, a Cas9-deaminase fusion protein demonstrates activity on non-canonical PAMs and therefore can correct all the pathogenic T>C or A>G mutations listed in Tables 4 and 5 (SEQ ID NOs: 674-2539 and 3144-5083), respectively. In some embodiments, a Cas9-deaminase fusion protein recognizes canonical PAMs and therefore can correct the pathogenic T>C or A>G mutations with canonical PAMs, e.g., 5′-NGG-3′. It should be appreciated that a skilled artisan would understand how to design an RNA (e.g., a gRNA) to target any of the Cas9 proteins or fusion proteins provided herein to any target sequence in order to correct any of the mutations provided herein, for example, the mutations provided in Tables 4 and 5. It will be apparent to those of skill in the art that in order to target a Cas9:effector domain fusion protein as disclosed herein to a target site, e.g., a site comprising a point mutation to be edited, it is typically necessary to co-express the Cas9:effector domain fusion protein together with a guide RNA, e.g., an sgRNA. As explained in more detail elsewhere herein, a guide RNA typically comprises a tracrRNA framework allowing for Cas9 binding, and a guide sequence, which confers sequence specificity to the Cas9:effector domain fusion protein. In some embodiments, the guide RNA comprises a structure 5′-[guide sequence]-guuuuagagcuagaaauagcaaguuaaaauaaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuuuuu-3′ (SEQ ID NO: 285), wherein the guide sequence comprises a sequence that is complementary to the target sequence. The guide sequence is typically 20 nucleotides long. The sequences of suitable guide RNAs for targeting Cas9:effector domain fusion proteins to specific genomic target sites will be apparent to those of skill in the art based on the instant disclosure. Such suitable guide RNA sequences typically comprise guide sequences that are complementary to a nucleic sequence within 50 nucleotides upstream or downstream of the target nucleotide to be edited.

Kits, Vectors, Cells

Some aspects of this disclosure provide polynucleotides encoding a Cas9 protein of a fusion protein as provided herein. Some aspects of this disclosure provide vectors comprising such polynucleotides. In some embodiments, the vector comprises a heterologous promoter driving expression of polynucleotide.

Some aspects of this disclosure provide cells comprising a Cas9 protein, a fusion protein, a nucleic acid molecule, and/or a vector as provided herein.

The description of exemplary embodiments of the reporter systems herein is provided for illustration purposes only and not meant to be limiting. Additional reporter systems, e.g., variations of the exemplary systems described in detail above, are also embraced by this disclosure.

EXAMPLES
Example 1: PACE Evolution of a Cas9 without PAM Sequence Restriction

Building PAM Libraries. Four different protospacer target sequences were synthesized: Doench 1-5′-AAGAGAGACAGTACATGCCC-3′ (SEQ ID NO: 286);

Doench 2-5′-GGAGCCCACCGAGTACCTGG-3′ (SEQ ID NO: 287); G7′-5′-AGTCTCCTCAGCAAAACGAA-3′ (SEQ ID NO: 288); and VEGF Target 2-5′-GACCCCCTCCACCCCGCCTC-3′ (SEQ ID NO: 289). For each protospacer target sequence, a 3′-NNN PAM library was built. While the canonical PAM sequence is 5′-NGG-3′, (e.g., an exemplary [Doench 1]-[canonical PAM] target sequence could be 5′-[AAGAGAGACAGTACATGCCC]-[NGG]-3′ (SEQ ID NO: 291)), the 3′NNN PAM libraries for each protospacer target sequence contained a fully random PAM sequence, e.g., for Doench1 5′-AAGAGAGACAGTACATGCCCNNN-3′ (SEQ ID NO: 290), wherein N represents any nucleotide. The NNN PAM libraries thus included every possible combination of PAM sequences at the 3′ end of the respective protospacer target sequence.

Testing the Activity of Cas9 on PAM Libraries in a ω-dCas9 luciferase assay. Cas9 activity was tested using a bacterial luciferase activation assay in which a fusion protein of the ω subunit of Escherichia coli RNA polymerase (rpoZ) to dCas9 (see, e.g., Bikard et al., Nucleic Acids Res. 2013 August; 41 (15): 7429-7437) drives the production of luciferase encoded by a nucleic acid under the control of a weak promoter comprising a sequence targeted by an sgRNA. Each PAM library was cloned into a plasmid comprising such a weak promoter, where the [target sequence]-[PAM library] nucleic acid sequences served as the sequence targeted by an sgRNA. A PAM library was cloned into the promoter for The ω-dCas9 assay was run on all four protospacer targets for both the canonical PAM and the random PAM library. FIG. 1 shows the activity of wild-type S. pyogenes Cas9 on PAM Libraries.

Evolution of Cas9 on PAM Libraries. S. pyogenes dCas9 was fused to the @ unit of RNA polymerase. The resulting ω-dCas9 fusion protein was cloned into an M13 phage-based selection phagemid (SP), comprising the entire M13 phage genome except for a functional version of the gene encoding pIII, a gene essential for the generation of infectious phage particles. The phage gene encoding pIII was provided on a separate plasmid (accessory plasmid, AP), under the control of a promoter that is transcriptionally activated by ω-dCas9. The PAM library was cloned into the promoter region of the accessory plasmid. Host cells used for the directed evolution of Cas9 proteins without PAM restriction were provided that harbored the accessory plasmid. Upon infection with a selection phage, the amount of infectious phage particles produced by a given host cell thus depends on the activity of the ω-dCas9 fusion protein encoded by the selection phage on the promoter of the accessory plasmid, which is required for the production of pIII protein. The accessory plasmid thus confers a selective advantage to those selection phages encoding ω-dCas9 fusion protein variants with an increased activity on different non-canonical PAM sequences.

A lagoon was provided and a flow of host cells comprising the accessory plasmid was generated through the lagoon. The host cells were contacted with the selection phagemid, resulting in a population of selection phage propagating in the flow of host cells in the lagoon. Phage-infected host cells were removed from the lagoon and fresh, uninfected host cells were fed into the lagoon at a rate resulting in the average time a host cell remained in the lagoon being shorter than the average time between cell division of the host cells, but longer than the average M13 phage life cycle time.

In order to generate Cas9 variants during a directed evolution experiment, the host cells in the lagoon were incubated under conditions resulting in an increased mutation rate. The host cells were harboring a mutagenesis plasmid (MP), which increased the mutagenesis rate, thus introducing mutations in the ω-dCas9 fusion protein encoded by the selection phagemid during the phage life cycle. Because the flow rate of host cells through the lagoon results in the average time a host cell remains in the lagoon being shorter than the average time between host cell divisions, the host cells in the lagoon cannot accumulate mutations resulting from the increased mutation rate conferred by the mutagenesis plasmid in their genome or on the accessory plasmid. The selection phage, however, replicate in the lagoon in the flow of host cells and thus accumulate mutations over time, resulting in the generation of new, evolved ω-dCas9 fusion protein variants.

If any of these evolved ω-dCas9 fusion protein variants includes a mutation that confers an increased activity on the accessory plasmid comprising the PAM library, this will directly translate into the generation of more pIII by a host cell infected with a selection phage encoding the respective ω-dCas9 fusion protein variant. The production of more pIII will, in turn, result in the generation of more infectious selection phage particles, which, over time, results in a competitive advantage of the mutant selection phage harboring such beneficial mutations over selection phage not harboring such mutations. After a period of time, the selective pressure exerted by the accessory plasmid will, therefore, result in selection phage having acquired beneficial mutations being the predominant species replicating in the flow of host cells, while selection phage with no mutations or with detrimental mutations will be washed out of the lagoon.

Because the ω-dCas9 fusion protein activity on the PAM library was very low at the beginning of the experiment, multiple rounds of overnight propagation of the selection phagemid in host cells harboring an accessory plasmid containing the PAM library were carried out to evolve Cas9 variants that show increased activity on noncanonical PAM sequences. At the end of a directed evolution experiment, the evolved population of selection phage was isolated from the lagoon, and a representative number of clones was analyzed to detect Cas9 variants having beneficial mutations. While all mutations observed confer a beneficial phenotype, mutations shared by more than one clone, or by all clones, are of particular interest.

Mutations from Cas9 PACE. A number of selection phage clones was isolated from a directed evolution experiment using a PAM library accessory plasmid as described above. The mutations identified in the Cas9 amino acid sequence of some exemplary clones is provided below in Table 1 (residue numbering according to SEQ ID NO: 9):

TABLE 1

Cas9 mutations identified in PACE (residue

numbering according to SEQ ID NO: 9.

Clone
Mutations

1

D182

E1219V

2

H137
D182

E1219V

3

D182
G660
E1219V

4
I122

D182

E1219V

Clones 1-4 were tested in the ω-dCas9 luciferase activation assay described above. When tested on the PAM library as a whole, the different clones showed an improvement in luciferase expression (FIG. 2—Cas9 activity of exemplary evolved clones on PAM library after directed evolution).

Improvement of Cas9 Activity on Non-Canonical PAM Sequences.

The activity of evolved Cas9 proteins on target sequences with noncanonical PAMs was evaluated in more detail. The relative activity of Clone 4, harboring 1122, D182, and E1219V mutations, for various [Doench 2 (5′-GGAGCCCACCGAGTACCTGG-3′ (SEQ ID NO: 287))]-[PAM] target sequences was tested in the ω-dCas9 luciferase activation assay and compared to the activity of wild-type dCas9.

Improvement of Cas9 Activity on Non-Canonical PAM Sequences.

TABLE 2

Relative activity of clone 4 on various PAM sequences.

Clone 4 dCas9
Wild-type dCas9

PAM
Luciferase Activity
Luciferase Activity

GTC
44.84
4.07

AGC
25.01
4.42

GAG
186.22
73.60

TTT
36.49
3.96

GTG
119.53
6.86

AGG
238.29
244.27

CAA
13.90
5.28

Example 2: PACE Evolution of a Cas9 without any PAM Sequence Restriction

Because the activity of the ω-dCas9 fusion protein on the NNN-PAM libraries was very low, a second round of PACE experiments was performed, in which an initial phase of diversification of the ω-dCas9 fusion protein population was carried out in the absence of selective pressure by providing a source of pIII that did not depend on ω-dCas9 fusion protein activity. The initial diversification stage allows mutations to develop that may not be accessible in a PACE experiment where selective pressure is applied throughout the experiment.

Selection phage harboring a ω-dCas9 fusion protein with a dCas9 sequence provided as SEQ ID NO: 8 with D10A and H840A mutations was propagated overnight in 1030 host cells together with MP6 mutagenesis plasmid in the presence of arabinose in order to create a library of mutated selection phage encoding a library of ω-dCas9 fusion protein variants. PIII was expressed from a separate plasmid in the host cells during this initial diversification stage. After overnight (12 h) diversification, 1030 host cells harboring an accessory plasmid comprising an NNN PAM library cloned into a weak promoter as the guide RNA target sequence and a mutagenesis plasmid were grown to log phase, and used as the source of host cells to create a flow of host cells through a lagoon. The cells in the lagoon were infected with the diversified selection phage from the overnight incubation. The host cells in the lagoon were contacted with arabinose in order to maintain a high level of expression of the mutagenic genes from the mutagenesis plasmid.

The initial phage titers were about 10⁸pfu/mL. A PACE experiment was performed for each of the four NNN-PAM libraries ([Doench 1]-[NNN-PAM], [Doench 2]-[NNN-PAM], [G7]-[NNN-PAM], and [VEGF target]-[NNN-PAM] cloned into an accessory plasmid driving pIII expression from a weak promoter as described above. The phage titers were monitored during the PACE experiments. A slow drop in phage titers to 10⁴pfu/mL was observed. The phage population was isolated from the lagoon at that point, and grown on 2208 host cells containing a separate source of pIII (psp-driven pIII). After this low-stringency propagation period, a 1:100 dilution of the supernatant was added to fresh host cells harboring the accessory plasmid as the only source of pIII in a new lagoon, and the PACE experiments were continued. No drop in phage titers was observed after this low-stringency incubation in 2208 cells.

One exemplary PACE experiment that was run for 72 hours. After that period of time, 24 surviving clones were isolated from the lagoon, sequenced, and characterized. The mutations identified included A262T, K294R, S409I, M694I, E480K, E543D, and E1219V (amino acid numbering according to SEQ ID NO: 9). In another exemplary experiment, surviving clones were isolated after 15 days of incubation. Activity of the identified dVas9 mutants was characterized in a ω-dCas9 luciferase assay. Clones with the best ω-dCas9 fusion protein activity on noncanonical PAM target sequences had the following mutations: E480K, E543D, E1219V, and T1329.

Cas9 Mammalian GFP Activation. Both wild-type dCas9 (SEQ ID NO: 9) and the evolved Cas9 clones were tested in a dCas9-GFP assay in Hek293T cells. The cells were contacted with a reporter construct in which a GFP-encoding sequence was driven from a weak promoter that includes a [gRNA target sequence]-[PAM] sequence. Fusion proteins of dCas9 (wild-type and PACE variants) attached to the transcriptional activator VP64-p65-Rta (VPR) were generated, and the various dCas9-VPR variants were tested for their capacity to activate the GFP reporter in HEK293 cells.

Hek293T were transfected with four separate plasmids: a dCas9-VPR expression plasmid; a plasmid expressing the sgRNA targeting the gRNA target sequence of the GFP reporter plasmid; the GFP reporter plasmid; and an iRFP transfection control. In one experiment, the HEK293 cells were contacted with a GFP reporter included a TAA PAM, and in another experiment, the HEK293 cells were contacted with a population of reporter plasmids containing an NNN PAM library. Cells were harvested 48 hours after transfection and GFP expressing cells were quantified using a BD LSR-FORTESSA cell analyzer.

FIG. 3—Cas9 Mammalian GFP Activation. Compared with WT Cas9, the evolved Cas9s showed much higher activity on both the TAA PAM (21.08% vs. 0.60% of cells above negative control) and a library of NNN PAM (22.76% vs. 3.38% of cells above negative control).

Evolved Cas9 Cutting Activity on Target Sequences with Noncanonical PAM.

In order to demonstrate that the PACE mutations universally confer Cas9 activity without PAM restriction, nuclease-active Cas9 proteins were generated based on the sequence provided in, i.e., without the D10A and H840A mutations, but harboring the various PACE mutations. The evolved Cas9 variants were tested in a Cas9 GFP assay, assessing the capacity of the evolved Cas9 protein variants to target and inactivate an emGFP gene integrated into the genome of HEK293 cells using a guide RNA targeting a sequence with a noncanonical PAM. It was observed that 6.45% of cells showed loss of GFP expression when contacted with a wild-type nuclease-active Cas9 (SEQ ID NO: 9), while 54.55% of cells contacted with the evolved Cas9 (E480K, E543D, E1219V, and T1329) showed a loss of GFP expression.

Example 3: Cas9 Variants without PAM Restrictions

The beneficial mutations conferring Cas9 activity on noncanonical PAM sequences were mapped to a S. pyogenes wild-type sequence. Below is an exemplary Cas9 sequence (S. pyogenes Cas9 with D10 and H840 residues marked with an asterisk following the respective amino acid residues, SEQ ID NO: 9). The D10 and H840 residues of SEQ ID NO: 9 may be mutated to generate a nuclease inactive Cas9 (e.g., to D10A and H840A) or to generate a nickase Cas9 (e.g., to D10A with H840; or to D10 with H840A). The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified. The residues found mutated in the clones isolated from the various PACE experiments, amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 are identified with an asterisk following the respective amino acid residue.

(SEQ ID NO: 9)

MDKKYSIGLD*IGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRK

NRICYLQEIFSNEMAKVDDSFFHRLEESELVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTDKADL

RLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIA

QLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILL

SDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPI

LEKMDGTEELLVKLNREDLLRKORTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPL

ARGNSRFAWMTRKSEETITPWNFEE*VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT

EGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKOLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDEL

DNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG*RLSRKLINGIRDKQSGKTILDEL

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The beneficial mutations conferring Cas9 activity on noncanonical PAM sequences were mapped to additional exemplary wild-type Cas9 sequences. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified. The residues homologous to the residues found mutated in SEQ ID NO: 9, amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 are identified with an asterisk following the respective amino acid residue. In addition, amino acid residues 10 and 840, which are mutated in dCas9 protein variants, are also identified by an asterisk.

(SEQ ID NO: 297)

MDKKYSIGLD*IGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFGSGETAEATRLKRTARRRYTRRK

NRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLADSTDKADL

RLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQIYNQLFEENPINASRVDAKAILSARLSKSRRLENLIA

QLPGEKRNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILL

SDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPI

LEKMDGTEELLVKLNREDLLRKORTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPL

ARGNSRFAWMTRKSEETITPWNFEE*VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT

EGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKOLKEDYFKKIECFDSVEISGVEDRFNASLGAYHDLLKIIKDKDEL

DNEENEDILEDIVLTLTLFEDRGMIEERLKTYAHLFDDKVMKQLKRRRYTGWG*RLSRKLINGIRDKQSGKTILDEL

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VVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGE*L

QKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKH

RDKPIREQAENIIHLFTLTNLGAPAAFKYFDT* IDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(SEQ ID NO: 298)

MDKKYSIGLA*IGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRK

NRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTDKADL

RLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIA

QLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILL

SDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPI

LEKMDGTEELLVKLNREDLLRKORTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPL

ARGNSRFAWMTRKSEETITPWNFEE*VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT

EGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRENASLGTYHDLLKIIKDKDEL

DNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKOLKRRRYTGWG*RLSRKLINGIRDKQSGKTILDEL

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LVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGE*

LQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNK

HRDKPIREQAENIIHLFTLTNLGAPAAFKYFDT*TIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD

(SEQ ID NO: 260)

>gi|504540549|ref WP_014727651.1|type II CRISPR RNA-guided endonuclease Cas9

[Streptococcus thermophilus]

MTKPYSIGLD*IGTNSVGWAVITDNYKVPSKKMKVLGNTSKKYIKKNLLGVLLFDSGITAEGRRLKRTARRRYTRRR

NRILYLQEIFSTEMATLDDAFFQRLDDSFLVPDDKRDSKYPIFGNL*VEEKAYHDEFPTIYH*LRKYLADSTKKADL

RLVYLALAHMIKYRGHFLIEGEFNSKNNDIQ*KNFQDFLDTYNAIFESDLSLENSKQLEEIVKDKISKLEKKDRILK

LFPGEKNSGIFSEFLKLIVGNQADFRKCFNLDEKA*SLHFSKESYDEDLETLLGYIGDDYSDVFLKAK*KLYDAILL

SGFLTVTDNETEAPLSSAMIKRYNEHKEDLALLKEYIRNISLKTYNEVFKDDTKNGYAGYIDGKTNQEDFYVYLKNL

LAEFEGADYFLEKIDREDFLRKORTFDNGS*IPYQIHLQEMRAILDKQAKFYPFLAKNKERIEKILTFRIPYYVGPL

ARGNSDFAWSIRKRNEKITPWNFED*VIDKESSAEAFINRMTSFDLYLPEEKVLPKHSLLYETENVYNELTKVRFIA

ESMRDYQFLDSK*QKKDIVRLYFKDKRKVTDKDIIEYLHAIYGYDGIELKGIEKQFNSSLSTYHDLLNIINDKEFLD

DSSNEAIIEEIIHTLTIFEDREMIKQRLSKFENIFDKSVLKKLSRRHYTGWG*KLSAKLINGIRDEKSGNTILDYLI

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IDRLSNYDIDH*IIPQAFLKDNSIDNKVLVSSASNRGKSDDFPSLEVVKKRKTFWYQLLKSKLISQRFDNTLK
AER

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GYAGISNSFAVLVKGTIEKGAKKKITNVLEFQGISILDRINYRKDKLNFLLEKGYKDIELIIELPKYSLFELSDGSR

RMLASILSTNNKRGE*IHKGNQIFLSQKFVKLLYHAKRISNTINENHRKYVENHKKEFEELFYYILEFNENYVGAKK

NGKLLNSAFQSWQNHSIDELCSSFIGPTGSERKGLFELTSRGSAADFEFLGV*KIPRYRDYTPSSLLKDATLIHQSV

TGLYETRIDLAKLGEG|Staphylococcus Aureus Cas9

(SEQ ID NO: 261)

GSHMKRNYILGLD*IGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRRRRHRIQRVKKLLFD

YNLLTDHSELSGINP*YEARVKGLSQKLSEEEFSAALLHLAKRRGVHNVNEVEEDTGNELST*KEQISRNSKALEEK

YVAELQLERLKKDGEVRGSINRFKTSDYVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKD

IKEWYEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYY*EKFQIIENVFKQKKKPTLKQIAK

EILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIYQSSEDIQEELTNLNSELTQE

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EGKCLYSLEAIPLEDLLNNPFNYEVDH*IIPRSVSFDNSFNNKVLVKQEEASKKGNRTPFQYLSSSDSKISYETFKK

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QKLKLIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDYPNS*RNKVVKLSLKPYR

FDVYLDNGVYKFVTVKNLDVIKKENYYEVNSKAYEEAKKLKKISNQAEFIASFYNNDLIKINGELYRVIGVNNDLLN

RIEVNMIDITYREYLEN*MNDKRPPRIIKTIASKTQSIKKYSTDILGNLYEVKSKKHPQIIKKG

This disclosure provides Cas9 variants in which one or more of the amino acid residues identified by an asterisk are mutated as described herein. In some embodiments, the D10 and H840 residues are mutated, e.g., to an alanine residue, and the Cas9 variants provided include one or more additional mutations of the amino acid residues identified by an asterisk as provided herein. In some embodiments, the D10 residue is mutated, e.g., to an alanine residue, and the Cas9 variants provided include one or more additional mutations of the amino acid residues identified by an asterisk as provided herein.

A number of Cas9 sequences from various species were aligned to determine whether corresponding homologous amino acid residues can be identified in other Cas9 proteins, allowing the generation of Cas9 variants with corresponding mutations of the homologous amino acid residues. The alignment was carried out using the NCBI Constraint-based Multiple Alignment Tool (COBALT (accessible at st-va.ncbi.nlm.nih.gov/tools/cobalt), with the following parameters. Alignment parameters: Gap penalties-11,-1; End-Gap penalties-5,-1. CDD Parameters: Use RPS BLAST on; Blast E-value 0.003; Find Conserved columns and Recompute on. Query Clustering Parameters: Use query clusters on; Word Size 4; Max cluster distance 0.8; Alphabet Regular.

An exemplary alignment of four Cas9 sequences is provided below. The Cas9 sequences in the alignment are: Sequence 1 (S1): SEQ ID NO: 10|WP_010922251| gi 499224711|type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes]; Sequence 2 (S2): SEQ ID NO: 11|WP_039695303|gi 746743737|type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus gallolyticus]; Sequence 3 (S3): SEQ ID NO: 12| WP_045635197|gi 782887988|type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mitis]; Sequence 4 (S4): SEQ ID NO: 13|5AXW_A|gi 924443546|Staphylococcus Aureus Cas9. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified for each of the four sequences. Amino acid residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in S1 and the homologous amino acids in the aligned sequences are identified with an asterisk following the respective amino acid residue.

S1 1 --MDKK-YSIGLD*IGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLI--GALLFDSG--ETAEATRLKRTARRRYT 73

S2 1 --MTKKNYSIGLD*IGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLL--GALLFDSG--ETAEATRLKRTARRRYT 74

S3 1 --M-KKGYSIGLD*IGTNSVGFAVITDDYKVPSKKMKVLGNTDKRFIKKNLI--GALLFDEG--TTAEARRLKRTARRRYT 73

S4 1 GSHMKRNYILGLD*IGITSVGYGII--DYET-----------------RDVIDAGVRLFKEANVENNEGRRSKRGARRLKR 61

S1 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTDKADLRL 153

S2 75 RRKNRLRYLQEIFANEIAKVDESFFQRLDESFLTDDDKTFDSHPIFGNK*AEEDAYHQKFPTIYH*LRKHLADSSEKADIRL 154

S3 74 RRKNRLRYLQEIFSEEMSKVDSSFFHRLDDSFLIPEDKRESKYPIFATL*TEEKEYHKQFPTIYH*LRKQLADSKEKTDLRL 153

S4 62 RRRHRIQRVKKLL--------------------------FDYNLLTD-------- HSELSGINP*YEARVKGLSQKLSEEE 107

S1 154 IYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEK 233

S2 155 VYLALAHMIKFRGHFLIEGELNAENTDVQ*KIFADFVGVYNRTFDDSHLSEITVDVASILTEKISKSRRLENLIKYYPTEK 234

S3 154 IYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEK 233

S4 108 FSAALLHLAKRRG------------------------------------------VHNVNEVEEDT----------------131

S1 234 KNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQISKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILLSDILRVNTEIT 313

S2 235 KNTLFGNLIALALGLQPNFKTNFKLSEDA*KLQFSKDTYEEDLEELLGKIGDDYADLFTSAK*NLYDAILLSGILTVDDNST 314

S3 234 STGLFSEFLKLIVGNQADFKKHFDLEDKA*PLQFSKDTYDEDLENLLGQIGDDFTDLFVSAK*KLYDAILLSGILTVTDPST 313

S4 132 ---------GNELS-----------------------------------T*KEQISRN------------------------ 144

S1 314 KAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILERM---DGTEELLV 391

S2 315 KAPLSASMIKRYVEHHEDLEKLKEFIKANKSELYHDIFKDKNKNGYAGYIENGVKQDEFYKYLKNILLSKIKIDGSDYFLD 394

S3 314 KAPLSASMIERYENHQNDLAALKQFIKNNLPEKYDEVFSDQSKDGYAGYIDGTTQETFYKYIKNLLISKF---EGTDYFLD 391

S4 145 -------SKALEEKYVAELQ---------------------------------------- -------LERLKKDG----- 165

S1 392 KLNREDLLRKQRTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEE 471

S2 395 KIEREDFLRKQRTFDNGS*IPHQIHLQEMHAILRRQGDYYPFLKEKQDRIEKILTFRIPYYVGPLVRKDSRFAWAEYRSDE 474

S3 392 KIEREDFLRKQRTFDNGS*IPHQIHLQEMNAILRRQEYYPFLYKDNKEKIEKILTFRIPYYVGPLARGNRDFAWLTRNSDE 471

S4 166 --EVRGSINRFKTSD-------------YVKEAKQLLKVQKAYHQLQSFIDTYIDLLETRRTYYEGP--GEGSPFGW---K 227

S1 472 TITPWNFEE*VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGE*QKKAIVDL 551

S2 475 KITPWNFDK*VIDKEKSAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVNEQGKE-SFFDSN*MKQEIFDH 553

S3 472 AIRPWNFEE*IVDKASSAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIAEGLRDYQFLDSG*QKKQIVNQ 551

S4 228 DIKEW-----------------YEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEK--LEYY*EKFQIIEN 289

S1 552 LFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDR---FNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFED 628

S2 554 VFKENRKVTKEKLLNYLNKEPPEYRIKDLIGLDKENKSFNASLGTYHDLKKIL-DKAFLDDKVNEEVIEDIIKTLTLFED 632

S3 552 LFKENRKVTEKDIIHYLHN-VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDKEFMDDAKNEAILENIVHTLTIFED 627

S4 290 VFKQKKKPTLKQIAKEILVNEEDIKGYRVTSTGKPEF---TNLKVYHDIKDITARKEII---ENAELLDQIAKILTIYQS 363

S1 629 REMIEERLKTYAHLFDDKVMKQLKR-RRYTGWG*RLSRRLINGIRDKQSGKTILDFLKSDGFANRNFM*QLIHDDSLTFRED 707

S2 633 KDMIHERLQKYSDIFTANQLKKLER-RHYTGWG*RLSYKLINGIRNKENNKTILDYLIDDGSANRNFM*QLINDDTLPFKQI 711

S3 628 REMIKQRLAQYDSLFDERVIKALTR-RHYTGWG*KLSAKLINGICDKQTGNTILDYLIDDGKINRNFM*QLINDDGLSFKEI 706

S4 364 SEDIQEELTNLNSELTQEEIEQISNLKGYGTH*NLSLKAINLILDE--------LWTNDNQIAIFNRL*KLVP--------- 428

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S1 782 KRIEEGIKELGSQIL-----KEIHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD-----YDVDH*IVPQSFLKDD 850

S2 785 KKLQNSLKELGSNILNEEKPSYIEDKVENSHLQNDQLFLYYIQNGKDMYTGDELDIDHLSD----YDIDH*IIPQAFIKDD 860

S3 780 KRIEDSLKILASGL---DSNILKENPTDNNQLQNDRLFLYYLQNGKDMYTGEALDINGLSS----YDIDH*IIPQAFIKDD 852

S4 506 ERIEKIIRTTGK---------------ENAKYLIEKIKLHDMQEGKCLYSLEAIPLEDLLNNPFNYEVDH*IIPRSVSFDN 570

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S1 1150 EKGKSKKLKSVKELLGITIMERSSFEKNPI-DFLEAKG----YKEVKKDLIIKLPKYSLFELENGRKRMLASAGE*LQKG 1223

S2 1159 EKGKAKKLKTVKELVGISIMERSFFEENPV-EFLENKG----YHNIREDKLIKLPKYSLFEFEGGRRRLLASASE*LQKG 1232

S3 1157 EKGKAKKLKTVKTLVGITIMEKAAFEENPI-TFLENKG----YHNVRKENILCLPKYSLFELENGRRRLLASAKE*LQKG 1230

S4 836 DPQTYQKLK--------LIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPIKKIKYYGNKLNAHLDITDDYPNS*RNKV 907

S1 1224 NELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKH------ 1297

S2 1233 NEMVLPGYLVELLYHAHRADNF----NSTEYLNYVSEHKKEFEKVLSCVEDFANLYVDVEKNLSKIRAVADSM------- 1301

S3 1231 NEIVLPVYLTTLLYHSKNVHKL----DEPGHLEYIQKHRNEFKDLLNLVSEFSQKYVLADANLEKIKSLYADN------- 1299

S4 908 VKLSLKPYRFD-VYLDNGVYKFV----TVKNLDVIK--KENYYEVNSKAYEEAKKLKKISNQAEFIASFYNNDLIKING 979

S1 1298 RDKPIREQAENIIHLFTLTNLGAPAAFKYFDT*TIDRKRYTSTKEVLDATLIHQSIT---------GLYETRI---DLSQL 1365

S2 1302 DNFSIEEISNSFINLLTLTALGAPADFNFLGE*KIPRKRYTSTKECINATLIHQSIT--------GLYETRI----DLSKL 1369

S3 1300 EQADIEILANSFINLLTFTALGAPAAFKFFGK*DIDRKRYTTVSEILNATLIHQSIT-------GLYTETWI----DLSKL 1367

S4 980 ELYRVIGVNNDLLNRIEVNMIDITYR-EYLEN*MNDKRPPRIIKTIASKT---QSIKKYSTDILGNLYEVKSKKHPQIIKK 1055

S1 1366 GGD 1368

S2 1370 GEE 1372

S3 1368 GED 1370

S4 1056 G00 1056

The alignment demonstrates that amino acid sequences and amino acid residues that are homologous to a reference Cas9 amino acid sequence or amino acid residue can be identified across Cas9 sequence variants, including, but not limited to Cas9 sequences from different species, by identifying the amino acid sequence or residue that aligns with the reference sequence or the reference residue using alignment programs and algorithms known in the art. This disclosure provides Cas9 variants in which one or more of the amino acid residues identified by an asterisk in SEQ ID NO: 9 are mutated as described herein. The residues in Cas9 sequences other than SEQ ID NO: 9 that correspond to the residues identified in SEQ ID NO: 9 by an asterisk are referred to herein as “homologous” or “corresponding” residues. Such homologous residues can be identified by sequence alignment, e.g., as described above, and by identifying the sequence or residue that aligns with the reference sequence or residue. Similarly, mutations in Cas9 sequences other than SEQ ID NO: 9 that correspond to mutations identified in SEQ ID NO: 9 herein, e.g., mutations of residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in SEQ ID NO: 9, are referred to herein as “homologous” or “corresponding” mutations. For example, the mutations corresponding to the D10A mutation in S1 for the four aligned sequences above are D10A for S2, D9A for S3, and D13A for S4; the corresponding mutations for H840A in S1 are H850A for S2, H842A for S3, and H560 for S4; the corresponding mutation for X1219V in S1 are X1228V for S2, X1226 for S3, and X903V for S4, and so on.

A total of 250 Cas9 sequences (SEQ ID NOs: 10-262) from different species were aligned using the same algorithm and alignment parameters outlined above. Amino acid residues homologous to residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 were identified in the same manner as outlined above. The alignments are provided below. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified for each of the four sequences. Residues corresponding to amino acid residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in SEQ ID NO: 9 are boxed in SEQ ID NO: 10 in the alignments, allowing for the identification of the corresponding amino acid residues in the aligned sequences.

Cas9 variants with one or more mutations in amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9 are provided herein. In some embodiments, the Cas9 variants provided herein comprise mutations corresponding to the D10A and the H840A mutations in SEQ ID NO: 9, resulting in a nuclease-inactive dCas9, and at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations of amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9.

Cas9 variants with one or more mutations in amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9 are provided herein. In some embodiments, the Cas9 variants provided herein comprise mutations corresponding to the D10A mutations in SEQ ID NO: 9, resulting in a partially nuclease-inactive dCas9, wherein the Cas9 can nick the non-target strand but not the targeted strand, and at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations of amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9.

WP_010922251.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 10

WP_039695303.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus gallolyticus] SEQ ID NO: 11

WP_045635197.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mitis] SEQ ID NO: 12

5AXW_A
Cas9, Chain A, Crystal Structure [Staphylococcus Aureus] SEQ ID NO: 13

WP_009880683.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 14

WP_010922251.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 15

WP_011054416.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 16

WP_011284745.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 17

WP_011285506.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 18

WP_011527619.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 19

WP_012560673.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 20

WP_014407541.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 21

WP_020905136.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 22

WP_023080005.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 23

WP_023610282.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 24

WP_030125963.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 25

WP_030126706.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 26

WP_031488318.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 27

WP_032460140.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 28

WP_032461047.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 29

WP_032462016.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 30

WP_032462936.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 31

WP_032464890.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 32

WP_033888930.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 33

WP_038431314.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 34

WP_038432938.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 35

WP_038434062.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes] SEQ ID NO: 36

BAQ51233.1
CRISPR-associated protein, Csn1 family [Streptococcus pyogenes] SEQ ID NO: 37

KGE60162.1
hypothetical protein MGAS2111_0903 [Streptococcus pyogenes MGAS2111] SEQ ID NO: 38

KGE60856.1
CRISPR-associated endonuclease protein [Streptococcus pyogenes SS1447] SEQ ID NO: 39

WP_002989955.1
MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO: 40

WP_003030002.1
MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO: 41

WP_003065552.1
MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO: 42

WP_001040076.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 43

WP_001040078.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 44

WP_001040080.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 45

WP_001040081.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 46

WP_001040083.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 47

WP_001040085.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 48

WP_001040087.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 49

WP_001040088.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 50

WP_001040089.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 51

WP_001040090.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 52

WP_001040091.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 53

WP_001040092.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 54

WP_001040094.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 55

WP_001040095.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 56

WP_001040096.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 57

WP_001040097.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 58

WP_001040098.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 59

WP_001040099.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 60

WP_001040100.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 61

WP_001040104.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 62

WP_001040105.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 63

WP_001040106.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 64

WP_001040107.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 65

WP_001040108.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 66

WP_001040109.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 67

WP_001040110.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 68

WP_015058523.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 69

WP_017643650.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 70

WP_017647151.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 71

WP_017648376.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 72

WP_017649527.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 73

WP_017771611.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 74

WP_017771984.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 75

CFQ25032.1
CRISPR-associated protein [Streptococcus agalactiae] SEQ ID NO: 76

CFV16040.1
CRISPR-associated protein [Streptococcus agalactiae] SEQ ID NO: 77

KLJ37842.1
CRISPR-associated protein Csn1 [Streptococcus agalactiae] SEQ ID NO: 78

KLJ72361.1
CRISPR-associated protein Csn1 [Streptococcus agalactiae] SEQ ID NO: 79

KLL20707.1
CRISPR-associated protein Csn1 [Streptococcus agalactiae] SEQ ID NO: 80

KLL42645.1
CRISPR-associated protein Csn1 [Streptococcus agalactiae] SEQ ID NO: 81

WP_047207273.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 82

WP_047209694.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 83

WP_050198062.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 84

WP_050201642.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 85

WP_050204027.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 86

WP_050881965.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 87

WP_050886065.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 88

AHN30376.1
CRISPR-associated protein Csn1 [Streptococcus agalactiae 138P] SEQ ID NO: 89

EAO78426.1
reticulocyte binding protein [Streptococcus agalactiae H36B] SEQ ID NO: 90

CCW42055.1
CRISPR-associated protein, SAG0894 family [Streptococcus agalactiae ILRI112] SEQ ID NO: 91

WP_003041502.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus anginosus] SEQ ID NO: 92

WP_037593752.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus anginosus] SEQ ID NO: 93

WP_049516684.1
CRISPR-associated protein Csn1 [Streptococcus anginosus] SEQ ID NO: 94

GAD46167.1
hypothetical protein ANG6_0662 [Streptococcus anginosus T5] SEQ ID NO: 95

WP_018363470.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus caballi] SEQ ID NO: 96

WP_003043819.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus canis] SEQ ID NO: 97

WP_006269658.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus constellatus] SEQ ID NO: 98

WP_048800889.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus constellatus] SEQ ID NO: 99

WP_012767106.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus dysgalactiae] SEQ ID NO: 100

WP_014612333.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus dysgalactiae] SEQ ID NO: 101

WP_015017095.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus dysgalactiae] SEQ ID NO: 102

WP_015057649.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus dysgalactiae] SEQ ID NO: 103

WP_048327215.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus dysgalactiae] SEQ ID NO: 104

WP_049519324.1
CRISPR-associated protein Csn1 [Streptococcus dysgalactiae] SEQ ID NO: 105

WP_012515931.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus equi] SEQ ID NO: 106

WP_021320964.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus equi] SEQ ID NO: 107

WP_037581760.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus equi] SEQ ID NO: 108

WP_004232481.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus equinus] SEQ ID NO: 109

WP_009854540.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus gallolyticus] SEQ ID NO: 110

WP_012962174.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus gallolyticus] SEQ ID NO: 111

WP_039695303.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus gallolyticus] SEQ ID NO: 112

WP_014334983.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus infantarius] SEQ ID NO: 113

WP_003099269.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus iniae] SEQ ID NO: 114

AHY15608.1
CRISPR-associated protein Csn1 [Streptococcus iniae] SEQ ID NO: 115

AHY17476.1
CRISPR-associated protein Csn1 [Streptococcus iniae] SEQ ID NO: 116

ESR09100.1
hypothetical protein IUSA1_08595 [Streptococcus iniae IUSA1] SEQ ID NO: 117

AGM98575.1
CRISPR-associated protein Cas9/Csnl, subtype II/NMEMI [Streptococcus iniae SF1] SEQ ID NO: 118

ALF27331.1
CRISPR-associated protein Csn1 [Streptococcus intermedius] SEQ ID NO: 119

WP_018372492.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus massiliensis] SEQ ID NO: 120

WP_045618028.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mitis] SEQ ID NO: 121

WP_045635197.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mitis] SEQ ID NO: 122

WP_002263549.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 123

WP_002263887.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 124

WP_002264920.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 125

WP_002269043.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 126

WP_002269448.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 127

WP_002271977.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 128

WP_002272766.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 129

WP_002273241.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 130

WP_002275430.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 131

WP_002276448.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 132

WP_002277050.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 133

WP_002277364.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 134

WP_002279025.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 135

WP_002279859.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 136

WP_002280230.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 137

WP_002281696.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 138

WP_002282247.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 139

WP_002282906.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 140

WP_002283846.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 141

WP_002287255.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 142

WP_002288990.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 143

WP_002289641.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 144

WP_002290427.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 145

WP_002295753.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 146

WP_002296423.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 147

WP_002304487.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 148

WP_002305844.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 149

WP_002307203.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 150

WP_002310390.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 151

WP_002352408.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 152

WP_012997688.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 153

WP_014677909.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 154

WP_019312892.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 155

WP_019313659.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 156

WP_019314093.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 157

WP_019315370.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 158

WP_019803776.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 159

WP_019805234.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 160

WP_024783594.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 161

WP_024784288.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 162

WP_024784666.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 163

WP_024784894.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 164

WP_024786433.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus mutans] SEQ ID NO: 165

WP_049473442.1
CRISPR-associated protein Csn1 [Streptococcus mutans] SEQ ID NO: 166

WP_049474547.1
CRISPR-associated protein Csn1 [Streptococcus mutans] SEQ ID NO: 167

EMC03581.1
hypothetical protein SMU69_09359 [Streptococcus mutans NLML4] SEQ ID NO: 168

WP_000428612.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus oralis] SEQ ID NO: 169

WP_000428613.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus oralis] SEQ ID NO: 170

WP_049523028.1
CRISPR-associated protein Csn1 [Streptococcus parasanguinis] SEQ ID NO: 171

WP_003107102.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus parauberis] SEQ ID NO: 172

WP_054279288.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus phocae] SEQ ID NO: 173

WP_049531101.1
CRISPR-associated protein Csn1 [Streptococcus pseudopneumoniae] SEQ ID NO: 174

WP_049538452.1
CRISPR-associated protein Csn1 [Streptococcus pseudopneumoniae] SEQ ID NO: 175

WP_049549711.1
CRISPR-associated protein Csn1 [Streptococcus pseudopneumoniae] SEQ ID NO: 176

WP_007896501.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pseudoporcinus] SEQ ID NO: 177

EFR44625.1
CRISPR-associated protein, Csn1 family [Streptococcus pseudoporcinus SPIN 20026] SEQ ID NO: 178

WP_002897477.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sanguinis] SEQ ID NO: 179

WP_002906454.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sanguinis] SEQ ID NO: 180

WP_009729476.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp. F0441] SEQ ID NO: 181

CQR24647.1
CRISPR-associated protein [Streptococcus sp. FF10] SEQ ID NO: 182

WP_000066813.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp. M334] SEQ ID NO: 183

WP_009754323.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp. taxon 056] SEQ ID NO: 184

WP_044674937.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO: 185

WP_044676715.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO: 186

WP_044680361.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO: 187

WP_044681799.1
type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO: 188

WP_049533112.1
CRISPR-associated protein Csn1 [Streptococcus suis] SEQ ID NO: 189

WP_029090905.1
type II CRISPR RNA-guided endonuclease Cas9 [Brochothrix thermosphacta] SEQ ID NO: 190

WP_006506696.1
type II CRISPR RNA-guided endonuclease Cas9 [Catenibacterium mitsuokai] SEQ ID NO: 191

AIT42264.1
Cas9hc : NLS : HA [Cloning vector pYB196] SEQ ID NO: 192

WP_034440723.1
type II CRISPR endonuclease Cas9 [Clostridiales bacterium S5-A11] SEQ ID NO: 193

AKQ21048.1
Cas9 [CRISPR-mediated gene targeting vector p (bhsp68-Cas9) ] SEQ ID NO: 194

WP_004636532.1
type II CRISPR RNA-guided endonuclease Cas9 [Dolosigranulum pigrum] SEQ ID NO: 195

WP_002364836.1
MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus] SEQ ID NO: 196

WP_016631044.1
MULTISPECIES: type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus] SEQ ID NO: 197

EMS75795.1
hypothetical protein H318_06676 [Enterococcus durans IPLA 655] SEQ ID NO: 198

WP_002373311.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 199

WP_002378009.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 200

WP_002407324.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 201

WP_002413717.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 202

WP_010775580.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 203

WP_010818269.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 204

WP_010824395.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 205

WP_016622645.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 206

WP_033624816.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 207

WP_033625576.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 208

WP_033789179.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecalis] SEQ ID NO: 209

WP_002310644.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 210

WP_002312694.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 211

WP_002314015.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 212

WP_002320716.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 213

WP_002330729.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 214

WP_002335161.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 215

WP_002345439.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 216

WP_034867970.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 217

WP_047937432.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus faecium] SEQ ID NO: 218

WP_010720994.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus hirae] SEQ ID NO: 219

WP_010737004.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus hirae] SEQ ID NO: 220

WP_034700478.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus hirae] SEQ ID NO: 221

WP_007209003.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus italicus] SEQ ID NO: 222

WP_023519017.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus mundtii] SEQ ID NO: 223

WP_010770040.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus phoeniculicola] SEQ ID NO: 224

WP_048604708.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus sp. AM1] SEQ ID NO: 225

WP_010750235.1
type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus villorum] SEQ ID NO: 226

AII16583.1
Cas9 endonuclease [Expression vector pCas9] SEQ ID NO: 227

WP_029073316.1
type II CRISPR RNA-guided endonuclease Cas9 [Kandleria vitulina] SEQ ID NO: 228

WP_031589969.1
type II CRISPR RNA-guided endonuclease Cas9 [Kandleria vitulina] SEQ ID NO: 229

KDA45870.1
CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI [Lactobacillus animalis] SEQ ID NO: 230

WP_039099354.1
type II CRISPR RNA-guided endonuclease Cas9 [Lactobacillus curvatus] SEQ ID NO: 231

AKP02966.1
hypothetical protein ABB45_04605 [Lactobacillus farciminis] SEQ ID NO: 232

WP_010991369.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria innocua] SEQ ID NO: 233

WP_033838504.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria innocua] SEQ ID NO: 234

EHN60060.1
CRISPR-associated protein, Csn1 family [Listeria innocua ATCC 33091] SEQ ID NO: 235

EFR89594.1
crispr-associated protein, Csn1 family [Listeria innocua FSL S4-378] SEQ ID NO: 236

WP_038409211.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria ivanovii] SEQ ID NO: 237

EFR95520.1
crispr-associated protein Csn1 [Listeria ivanovii FSL F6-596] SEQ ID NO: 238

WP_003723650.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 239

WP_003727705.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 240

WP_003730785.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 241

WP_003733029.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 242

WP_003739838.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 243

WP_014601172.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 244

WP_023548323.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 245

WP_031665337.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 246

WP_031669209.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 247

WP_033920898.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO: 248

AKI42028.1
CRISPR-associated protein [Listeria monocytogenes] SEQ ID NO: 249

AKI50529.1
CRISPR-associated protein [Listeria monocytogenes] SEQ ID NO: 250

EFR83390.1
crispr-associated protein Csn1 [Listeria monocytogenes FSL F2-208] SEQ ID NO: 251

WP_046323366.1
type II CRISPR RNA-guided endonuclease Cas9 [Listeria seeligeri] SEQ ID NO: 252

AKE81011.1
Cas9 [Plant multiplex genome editing vector pYLCRISPR/Cas9Pubi-H] SEQ ID NO: 253

CUO82355.1
Uncharacterized protein conserved in bacteria [Roseburia hominis] SEQ ID NO: 254

WP_033162887.1
type II CRISPR RNA-guided endonuclease Cas9 [Sharpea azabuensis] SEQ ID NO: 255

AGZ01981.1
Cas9 endonuclease [synthetic construct] SEQ ID NO: 256

AKA60242.1
nuclease deficient Cas9 [synthetic construct] SEQ ID NO: 257

AKS40380.1
Cas9 [Synthetic plasmid pFC330] SEQ ID NO: 258

4UN5_B
Cas9, Chain B, Crystal Structure SEQ ID NO: 259

WP_010922251
1

embedded image

73

WP_039695303
1
MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_045635197
1
K-KG-YSIGLDIGTNSVGFAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA--EARRLKRTARRRYT
73

5AXW_A
1
MKRN-YILGLDIGITSVGYGII--DYET------------RDVIDA---GVRLFKEANVEnnEGRRSKRGARRLKR
61

WP_009880683

---------------------------------------------------------------------------

WP_010922251
1
MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_011054416
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKGLGNTDRHGIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_011284745
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_011285506
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_011527619
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGEIA--EATRLKRTARRRYT
73

WP_012560673
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_014407541
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFGSGETA--EATRLKRTARRRYT
73

WP_020905136
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_023080005
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKVLGNTDRHGIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_023610282
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKVLGNTDRHGIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_030125963
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_030126706
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHGIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_031488318
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_032460140
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_032461047
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_032462016
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_032462936
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_032464890
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGEIA--EATRLKRTARRRYT
73

WP_033888930

---------------------------------------------------------------------------

WP_038431314
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_038432938
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_038434062
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

BAQ51233

---------------------------------------------------------------------------

KGE60162

---------------------------------------------------------------------------

KGE60856

---------------------------------------------------------------------------

WP_002989955
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGEIA--EATRLKRTARRRYT
73

WP_003030002
1
MDQK-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
73

WP_003065552
1
MTKKNYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_001040076
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKIRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040078
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040080
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040081
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040083
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040085
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040087
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040088
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040089
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040090
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040091
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040092
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040094
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040095
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040096
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040097
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040098
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040099
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040100
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040104
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_001040105
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTSRRRYT
73

WP_001040106
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_001040107
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_001040108
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_001040109
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_001040110
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_015058523
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_017643650
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_017647151
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_017648376
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_017649527
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_017771611
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_017771984
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

CFQ25032
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

CFV16040
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

KLJ37842
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

KLJ72361
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

KLL20707
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

KLL42645
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_047207273
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGRNTA--ADRRLKRTARRRYT
73

WP_047209694
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_050198062
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_050201642
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_050204027
1
MNKP-YSIGLDIGTNSVGYSVVTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT
73

WP_050881965
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

WP_050886065
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

AHN30376
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

EAO78426
1
MNKP-YSIGXDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRTARRRYT
73

CCW42055
1
MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--ADRRLKRIARRRYT
73

WP_003041502
1
MNQK-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
73

WP_037593752
1
MKKE-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_049516684
1
MKKE-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

GAD46167
1
MKKE-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
73

WP_018363470
1
MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_003043819
1
MEKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTNRKSIKKNLMGALLFDSGETA--EATRLKRTARRRYT
73

WP_006269658
1
MGKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
73

WP_048800889
1
MTQK-YSIGLDIGTNSVGWAIVIDDYKVPAKKMKILGNTNKQYIKKNLLGALLFDSGETA--KATRLKRTARRRYT
73

WP_012767106
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_014612333
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_015017095
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_015057649
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_048327215
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_049519324
1
MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_012515931
1
MKKP-YTIALDIGTNSVGWVVVTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA--EGTRLKRTARRRYT
73

WP_021320964
1
MKKP-YTIALDIGTNSVGWVVVTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA--EGTRLKRTARRRYT
73

WP_037581760
1
MKKP-YTIALDIGTNSVGWVVVTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA--EGTRLKRTARPRYT
73

WP_004232481
1
M-EKtYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRAARRRYT
73

WP_009854540
1
MTKKNYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_012962174
1
MTEKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDNGETA--EATRLKRTARRRYT
74

WP_039695303
1
MTKKNYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EATRLKRTARRRYT
74

WP_014334983
1
M-EKSYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA--EVTRLKRTARRRYT
73

WP_003099269
1
MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA--EATRLKRITRRRYT
73

AHY15608
1
MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA--EATRLKRTTRRRYT
73

AHY17476
1
MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA--EATRLKRTTRRRYT
73

ESR09100

---------------------------------------------------------------------------

AGM98575
1
MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA--EATRLKRTTRRRYT
73

ALF27331
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_018372492
1
MKKP-YSIGLDIGTNSVGWAVVMEDYKVPSKKMKVLGNTDKQSIKKNLIGALLFDSGETAV--ERRLNRTTSRRYD
73

WP_045618028
1
NNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLLGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_045635197
1
K-KG-YSIGLDIGTNSVGFAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA--EARRLKRTARRRYT
73

WP_002263549
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002263887
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002264920
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002269043
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002269448
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002271977
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002272766
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002273241
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002275430
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_002276448
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002277050
1
MKKS-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002277364
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_002279025
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002279859
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002280230
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_002281696
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_002282247
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002282906
1
MKKP-YSIGLDIGTNSVGWSVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002283846
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002287255
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVSAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002288990
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002289641
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTTRRRYT
73

WP_002290427
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002295753
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002296423
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002304487
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002305844
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002307203
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002310390
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_002352408
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_012997688
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_014677909
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPDKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_019312892
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_019313659
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_019314093
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_019315370
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_019803776
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_019805234
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_024783594
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_024784288
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTARRRYT
73

WP_024784666
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_024784894
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTTRRRYT
73

WP_024786433
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_049473442
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
73

WP_049474547
1
MKKP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--EDRRLKRTTRRRYT
73

EMC03581
1
MDL--------IGTNSVGWAVVIDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA--ADRRLKRTARRRYT
66

WP_000428612
1
ENKN-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA--EARRLKRTARRRYT
74

WP_000428613
1
ENKN-YSIGLDIGTNSVGWSVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA--EARRLKRTARRRYT
74

WP_049523028
1
K-KP-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNINKESIKKNLIGALLFDAGNTA--ADRRLKRTARRRYT
73

WP_003107102
1
--------------------------------MKVLGNTDRQTVKKNMIGTLLFDSGETA--EARRLKRTARRRYT
42

WP_054279288
1
-KKS-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTSRQSIKKNMIGALLFDEGGPA--ASTRVKRTTRRRYT
75

WP_049531101
1
SNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_049538452
1
SNKP-YSIGLDIGTNSVGWVIITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_049549711
1
SNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMTVLGNTDKHFIKKNLIGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_007896501
1
--YS-YSIGLDIGTNSVGWAVINEDYKVPAKKMTVFGNTDRKTIKKNLLGTVLFDSGETA--QARRLKRINRRRYT
75

EFR44625
1
-----------------------------------------------MLGTVLFDSGETA--QARRLKRTNRRRYT
27

WP_002897477
1
K-KP-YSIGLDIGTNSVGWAVVTDDYKVPAKKMRVFGDTDRSHIKKNLLGTLLFDDGNTA--ESRRLKRTARRRYT
73

WP_002906454
1
K-KP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA--EDRRLKRTSRRRYT
73

WP_009729476
1
ENKN-YSIGLDIGTNSVGWSVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA--EARRLKRTARRRYT
74

CQR24647
1
MKKP-YSIGLDIGTNSVGWSVVTDDYKVPAKKMKVLGNTDKEYIKKNLIGALLFDSGETA--EATRMKRTARRRYT
73

WP_000066813
1
SNKS-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_009754323
1
NNNN-YSIGLDIGTNSVGWAVITDDYKVPSKKMRVLGNTDKRFIKKNLIGALLFDEGTTA--EDRRLKRTARRRYT
74

WP_044674937
1
MKKK-YAIGIDIGTNSVGWSVVIDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA--ENRRLKRTARRRYT
73

WP_044676715
1
MKKK-YAIGIDIGTNSVGWSVVTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA--ENRRLKRTARRRYT
73

WP_044680361
1
MKKK-YAIGIDIGTNSVGWSVVTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA--ENRRLKRTARRRYT
73

WP_044681799
1
MKKK-YAIGIDIGTNSVGWSVVTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA--ENRRLKRTARRRYT
73

WP_049533112
1
MDQK-YSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA--EATRLKRTARRRYT
73

WP_029090905
1
-----------------------------------------------MWGVSLFEAGKTA--AERRGYRSTRRRLN
27

WP_006506696
1
I-VD-YCIGLDLGTGSVGWAVVDMNHRLMKRN------------GKHLWGSRLFSNAETA--ANRRASRSIRRRYN
60

AIT42264
1
MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_034440723
1
-MKN-YTIGLDIGTNSVGWAVIKDDLTLVRKKIKISGNTDKKEVKKNLWGSFLFEQGDTA--QDTRVKRIARRRYE
72

AKQ21048
1
MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

WP_004636532
1
MQKN-YTIGLDIGTNSVGWAVMKDDYTLIRKRMKVLGNTDIKKIKKNFWGVRLFDEGETA--KETRLKRGTRRRYQ
73

WP_002364836
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_016631044
1
--------------------------------------------------MRLFEEGHTA--EDRRLKRTARRRIS
24

EMS75795

----------------------------------------------------------------------------

WP_002373311
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_002378009
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_002407324
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_002413717
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_010775580
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_010818269
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_010824395
1
MKKD-YVIGLDIGSNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_016622645
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_033624816
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_033625576
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_033789179
1
MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA--EDRRLKRTARRRIS
73

WP_002310644
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002312694
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002314015
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002320716
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002330729
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002335161
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_002345439
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_034867970
1
MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNEWGARLFDEGQTA--EFRRTKRINRRRLA
73

WP_047937432
1
MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA--EARRSKRTARRRLA
73

WP_010720994
1
MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA--EFRRTKRINRRRLA
73

WP_010737004
1
MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA--EFRRTKRINRRRLA
73

WP_034700478
1
MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA--EFRRTKRINRRRLA
73

WP_007209003
1
MKND-YTIGLDIGTNSVGYSVVTDDYKVISKKMNVFGNTEKKSIKKNFWGVRLFESGOTA--QEARMKRTSRRRIA
73

WP_023519017
1
MEKE-YTIGLDIGTNSVGWAVLTDDYRLVARKMSIQGDSNRKKIKKNFWGARLFEEGKTA--QFRRIKRTNRRRIA
73

WP_010770040
1
MKKE-YTIGLDIGTNSVGWAVLTENYDLVKKKMKVYGNTETKYLKKNLWGVRLFDEGETA--ADRRLKRTTRRRYS
73

WP_048604708
1
MGKE-YTIGLDIGTNSVGWAVLQEDLDLVRRKMKVYGNTEKNYLKKNFWGVDLFDEGMTA--KDTRLKRTTRRRYF
73

WP_010750235
1
MNKA-YTLGLDIGTNSVGWAVVTDDYRLMAKKMPVHSKMEKKKIKKNEWGARLFDEGQTA--EERRNKRATRRRLR
73

AII16583
1
ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
112

WP_029073316
1
NNKI-YNIGLDIGDASVGWAVVDEHYNLLKRH------------GKHMWGSRLFTQANTA--VERRSSRSTRRRYN
65

WP_031589969
1
NNKI-YNIGLDIGDASVGWAVVDEHYNLLKRH------------GKHMWGSRLFTQANTA--VERRSSRSTRRRYN
65

KDA45870
1
LKKD-YSIGLDIGTNSVGHAVVIDDYKVPTKKMKVFGDISKKTIKKNMLGVLLFNEGQTA--ADTRLKRGARRRYT
74

WP_039099354
1
MSRP-YNIGLDIGTSSIGWSVVDDQSKLVSVR------------GKYGYGVRLYDEGQTA--AERRSFRTTRRRLK
61

AKP02966
1
KEQP-YNIGLDIGTGSVGWAVINDNYDLLNIK------------KKNLWGVRLFEGAQTA--KETRLNRSTRRRYR
64

WP_010991369
1
MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA--ADRRMARTARRRIE
73

WP_033838504
1
MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA--ADRRMARTARRRIE
73

EHN60060
1
MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA--ADRRMARTARRRIE
76

EFR89594

----------------------------------------------------------------------------

WP_038409211
1
MRKP-YTIGLDIGTNSVGWAVLTDQYNLVKRKMKVAGSAEKKQIKKNFWGVRLFDEGEVA--AGRRMNRTTRRRIE
73

EFR95520

----------------------------------------------------------------------------

WP_003723650
1
MKNP-YTIGLDIGTNSVGWAVLINQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_003727705
1
MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_003730785
1
MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_003733029
1
MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKISGDSEKKQIKKNFWGVRLFEKGETA--AKRRMSRTARRRIE
73

WP_003739838
1
MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDEGETA--ADRRMNRTARRRIE
73

WP_014601172
1
MKNP-YTIGLDIGTNSVGWAVLINQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_023548323
1
MKNP-YTIGLDIGTNSVGWAVLINQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_031665337
1
MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

WP_031669209
1
MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKISGDSEKKQIKKNFWGVRLFEKGETA--AKRRMSRTARRRIE
73

WP_033920898
1
MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
73

AKI42028
1
MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
76

AKI50529
1
MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA--VDRRMNRTARRRIE
76

EFR83390

----------------------------------------------------------------------------

WP_046323366
1
MKKP-YTIGLDIGTNSVGWAALTDQYDLVKRKMKVAGNSEKKQIKKNLWGVRLVDEGKTA--AHRRVNRTTRRRIE
73

AKE81011
1
ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
89

CUO82355
1
I-VD-YCIGLDLGTGSVGWAVVDMNHRLMKRN------------GKHLWGSRLFSNAETA--ATRRSSRSIRRRYN
64

WP_033162887
1
KDIR-YSIGLDIGTNSVGWAVMDEHYELLKKG------------NHHMWGSRLFDAAEPA--ATRRASRSIRRRYN
65

AGZ01981
1
ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
106

AKA60242
1
MDKK-YSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

AKS40380
1
MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
73

4UN5_B
1
MDKK-YSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA--EATRLKRTARRRYT
77

WP_010922251
74

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143

WP_039695303
75
RRKNRLRYLQEIFANEIAKVDESFFQRLDE-SFLT--DDDKT---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
144

WP_045635197
74
RRKNRLRYLQEIFSEEMSKVDSSFFHRLDD-SFLI--PEDKR---E SKYPIFATLT-EEKEYHKQFPTIYHLRKQLA
143

5AXW_A
62
RRRHRIQRVKKLLFD---------YNLLTDhSELS----------G --NPYEARVK--------------GLSQKLS
104

WP_009880683

---------------------------------------------- -------------------------------

WP_010922251
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_011054416
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_011284745
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_011285506
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_011527619
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_012560673
74
RRKNRICYLQEIFSNEIAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_014407541
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_020905136
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_023080005
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_023610282
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_030125963
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_030126706
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_031488318
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_032460140
74
RRKNRICYLQEIFSNEIAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_032461047
74
RRKNRICYLQEIFSNEIAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_032462016
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_032462936
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_032464890
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_033888930

---------------------------------------------- -------------------------------

WP_038431314
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_038432938
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_038434062
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

BAQ51233
1
----------------MAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
54

KGE60162

---------------------------------------------- -------------------------------

KGE60856

---------------------------------------------- -------------------------------

WP_002989955
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_003030002
74
RRRNRLRYLQEIFAEEMNKVDENFFQRLDD-SELV--DEDKR---G ERHPIFGNIA-AEVKYHDDFPTIYHLRKHLA
143

WP_003065552
75
RRKNRLRYLQEIFAEEMTKVDESFFQRLDE-SFLRwdDDNKK---L GRYPIFGNIA-DVVKYHQEFPTIYHLRKHLA
146

WP_001040076
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040078
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFPTIYHLRKELA

WP_001040080
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040081
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040083
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040085
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040087
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040088
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040089
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040090
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040091
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040092
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_001040094
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040095
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040096
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040097
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040098
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040099
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040100
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_001040104
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYXIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040105
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_001040106
74
CRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_001040107
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_001040108
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_001040109
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_001040110
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_015058523
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_017643650
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_017647151
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_017648376
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_017649527
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFPTIYHLRKELA
143

WP_017771611
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_017771984
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

CFQ25032
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

CFV16040
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

KLJ37842
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

KLJ72361
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

KLL20707
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

KLL42645
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_047207273
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_047209694
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKYYHEKFPTIYHLRKELA
143

WP_050198062
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_050201642
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

WP_050204027
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EDDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_050881965
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATlQ-EEKDYHEKFPTIYHLRKELA
143

WP_050886065
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

AHN30376
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

EAO78426
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--EEDKR---G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA
143

CCW42055
74
RRRNRILYLQEIFAEKMSKVDDSFFHRLED-SFLV--EEDKR---G SKYPIFATLQ-EEKDYHEKFPTIYHLRKELA
143

WP_003041502
74
RRRNRLRYLQEIFAEEMMQVDESFFQRLDD-SFLV--DEDKR---G ERHPIFGNIA-AEVKYHDEFPTIYHLRKHLA
143

WP_037593752
75
RRKNRLRYLQEIFTEEMNKVDENFFQRLDD-SFLV--EEDKQ---G SKYPIFGTLK-EEKEYHKKFKTIYHLREELA
144

WP_049516684
75
RRRNRLRYLQEIFAEEMMQVDESFFQRLDD-SELV--EEDKR---G SRYPIFGNIA-AEVKYHDDFPTIYHLRKHLV
144

GAD46167
74
RRKNRLRYLQEIFTEEMNKVDENFFQRLDD-SFLV--EEDKQ---G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA
143

WP_018363470
75
RRKNRLRYLQDIFTEEMAKVDDSFFQRLDE-SFLT--DNDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
144

WP_003043819
74
RRKNRIRYLQEIFANEMAKLDDSFFQRLEE-SFLV--EEDKK---N ERHPIFGNLA-DEVAYHRNYPTIYHLRKKLA
143

WP_006269658
74
RRKNRLRYLQEIFTGEMNKVDENFFORLDD-SFLV--DEDKR---G EHHPIFGNIA-AEVKYHDDFPTIYHLRRHLA
143

WP_048800889
74
RRKNRLRYLQEIFIEEMNKVDENFFQRLDD-SFLV--TEDKR---G SKYPIFGTLK-EEKEYYKEFETIYHLRKRLA
143

WP_012767106
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_014612333
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_015017095
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_015057649
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_048327215
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_049519324
74
RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA
143

WP_012515931
74
RRKNRLRYLKEIFTEEMAKVDDGFFQRLED-SFYV--LEDKE---G NKHPIFANLA-DEVAYHEKYPTIYHLRKKLV
143

WP_021320964
74
RRKNRLRYLKEIFTEEMAKVDDGFFQRLED-SFYV--LEDKE---G NKHPIFANLA-DEVAYHKKYPTIYHLRKELV
143

WP_037581760
74
RRKNRLRFLKEIFTEEMAKVDDGFFQRLED-SFYV--LEDKE---G NKHPIFANLA-DEVAYHKKYPTIYHLRKELV
143

WP_004232481
74
RRKNRLRYLQEIFAKEMAKVDESFFQRLEE-SFLT--DDDKT---F DSHPIFGNKA-EEDTYHQEFPTIYHLRKHLA
143

WP_009854540
75
RRKNRLRYLQEIFAEEMTKVDESFFYRLDE-SFLT--TDEKD---F ERHPIFGNKA-EEDAYHQKFPTIYHLRNYLA
144

WP_012962174
75
RRKNRLRYLQEIFAEEMAKVDESFFYRLDE-SFLT--TDDKD---F ERHPIFGNKA-DEIKYHQEFPTIYHLRKHLA
144

WP_039695303
75
RRKNRLRYLQEIFANEIAKVDESFFQRLDE-SFLT--DDDKT---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
144

WP_014334983
74
RRKNRLRYLQEIFAKEMTKVDESFFQRLEE-SFLT--DDDKT---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKYLA
143

WP_003099269
74
RRKYRIKELQKIFSSEMNELDIAFFPRLSE-SFLV--SDDKE---F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA
143

AHY15608
74
RRKYRIKELQKIFSSEMNELDIAFFPRLSE-SFLV--SDDKE---F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA
143

AHY17476
74
RRKYRIKELQKIFSSEMNELDIAFFPRLSE-SELV--SDDKE---F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA
143

ESR09100

---------------------------------------------- -------------------------------

AGM98575
74
RRKYRIKELQKIFSSEMNELDIAFFPRLSE-SFLV--SDDKE---F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA
143

ALF27331
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_018372492
74
RRRNRIRYLQHIFAEEMNRADENFFHRLKE-SFFV--EEDKT---Y SKYPIFGTLE-EEKNYHKNYPTIYHLRKTLA
143

WP_045618028
75
RRKNRLRYLQEIFTEEMSKVDISFFHRLDD-SFLV--PEDKR---G SKYPIFATLE-EEKEYHKNGPTIYHLRKHLA
144

WP_045635197
74
RRKNRLRYLQEIFSEEMSKVDSSFFHRLDD-SFLI--PEDKR---E SKYPIFATLT-EEKEYHKQFPTIYHLRKQLA
143

WP_002263549
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002263887
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002264920
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLDE-SFLT--DDDKN---F DSYPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_002269043
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002269448
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002271977
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002272766
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002273241
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002275430
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002276448
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002277050
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLDE-SFLT--DDDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_002277364
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002279025
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-FFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002279859
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLDE-SFLT--DDDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_002280230
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002281696
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002282247
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLDE-SFLT--DDDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_002282906
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002283846
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002287255
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002288990
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002289641
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002290427
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002295753
74
RRRNRILYLQEIFSEEMGKVNDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002296423
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002304487
74
RRRNRILYLQEIFAEEMMQVDESFFQRLDD-SFLV--EEDKR---G SRYPIFGTLK-EEKKYHKEFKTIYHLREKLA
143

WP_002305844
74
RRRNRILYLQEIFSEEMDKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002307203
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002310390
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_002352408
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_012997688
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_014677909
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019312892
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019313659
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019314093
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019315370
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019803776
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SELV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_019805234
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_024783594
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_024784288
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLDE-SFLT--DDDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_024784666
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_024784894
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

WP_024786433
74
RRRNRILYLQEIFAEEMNKVDDSFFHRLDE-SFLT--DDDKN---F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA
143

WP_049473442
74
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYYENFPTIYHLRQYLA
143

WP_049474547
74
RRRNRILYLQEIFSEEMGKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
143

EMC03581
67
RRRNRILYLQEIFAEEMSKVDDSFFHRLED-SFLV--TEDKR---G ERHPIFGNLE-EEVKYHENFPTIYHLRQYLA
136

WP_000428612
75
RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD-SFLI--PEDKK---G SKYPIFATLI-EEKEYHKQFPTIYHLRKQLA
144

WP_000428613
75
RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD-SFLI--PEDKR---G SKYPIFATLI-EEKEYHKQFPTIYHLRKQLA
144

WP_049523028
74
RRRNRILYLQEIFAAEMNKVDESFFHRLDD-SFLV--PEDKR---G SKYPIFGTLR-EEKEYHKQFPTIYYLRKILA
143

WP_003107102
43
RRINRIKYLOSIFDDEMSKIDSAFFQRIKD-SFLV--PDDKN---D DRHPIFGNIK-DEVDYHKNYPTIYHLRKKLA
112

WP_054279288
76
RRKNRLCYLRDIFESEMHTIDKHFFLRLED-SFLH--KSDKR---Y EAHPIFGTLQ-EEKAYHDNYPTIYHLRKALA
145

WP_049531101
75
RRKNRLRYLQEIFSEEISKVDNSFFHRLDD-SFLV--PEDKR---G SKYPIFATLT-EEKEYYKQFPTIYHLRKQLA
144

WP_049538452
75
RRKNRLRYLQEIFAEEMNKVDSSFFHRLDD-SFLV--PEDKR---G SKYPIFATLA-EEKEYHKQFPTIYHLRKQLA
144

WP_049549711
75
RRKNRLRYLQEIFSGEMSKVDSSFFHRLDD-SFLV--PEDKR---G SKYPIFATLV-EEKEYHKQFPTIYHLRKQLA
144

WP_007896501
76
RRRYRLCQLQNIFATEMVKVDDTFFQRLSE-SFFY--YQDKA---F DKHPIFGNSK-EERAYHKTYPTIYHLRKDLA
145

EFR44625
28
RRRYRLCQLQNIFATEMVKVDDTFFQRLSE-SFFY--YQDKA---F DKHPIFGNSK-EERAYHKTYPTIYHLRKDLA
97

WP_002897477
74
RRRNRILYLQEIFTESMNEIDESFFHRLDD-SFLV--PEDKR---G SKYPIFATLQ-EEKEYHKQFPTIYHLRKQLA
143

WP_002906454
74
RRKNRLRYLQEIFSEEISKLDSSFFHRLDD-SFLV--PEDKR---G SKYIFATLE-EEKEYHKKFPTIYHLRKHLA
143

WP_009729476
75
RRKNRLRYLQEIFSEEIGKVDSSFFHRLDD-SFLI--PEDKR---G SKYPIFATLA-EEKKYHKQFPTIYHLRKQLA
144

CQR24647
74
RRRNRILYLQDIFSPELNQVDESFLHRLDD-SFLVa--EDKR---G ERHVIFGNIA-DEVKYHKEFPTIYHLRKHLA
143

WP_000066813
75
RRKNRLRYLQEIFSQEISKVDSSFFHRLDD-FFLV--PEDKR---G SKYPIFATLV-EEKEYHKKFPTIYHLRKHLA
144

WP_009754323
75
RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD-SFLV--PEDKS---G SKYPIFATLA-EEKEYHKKFPTIYHLRKHLA
144

WP_044674937
74
RRRNRILYLQEIFAEEINKIDDSFFQRLDD-SFLIv--EDKQ---G SKHPIFGTLQ-EEKKYHKQFPTIYHLRKQLA
143

WP_044676715
74
RRRNRILYLQEIFAEEINKIDDSFFQRLDD-SFLIv--EDKQ---G SKHPIFGTLQ-EEKEYHKQFPTIYHLRKQLA
143

WP_044680361
74
RRRNRILYLQEIFAEEINKIDDSFFQRLDD-SFLIv--EDKQ---G SKHPIFGTLQ-EEKEYHKQFPTIYHLRKQLA
143

WP_044681799
74
RRRNRILYLQEIFAEEINKIDDSFFQRLDD-SFLIv--EDKQ---G SKHPIFGTLQ-EEKEYHKQFPTIYHLRKQLA
143

WP_049533112
74
RRRNRLRYLQEIFAEEMNKVDENFFQRLDD-SFLV--DEDKR---G ERHPIFGNIA-AEVKYHDDFPTIYHLRKHLA
143

WP_029090905
28
HRKFRLRLLEDMFEKEILSKDPSFFIRLKE-AFLSpkDEQKQ---F ----LFNDKDyTDADYYEQYKTIYHLRYDLI
100

WP_006506696
61
KRRERIRLLRAILQDMVLEKDPTFFIRLEHtSFLD--EEDKAky1G DNYNLFIDEDfNDYTYYHKYPTIYHLRKALC
139

AIT42264
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_034440723
73
RRRFRIRELQKIFDKSMGEVDSNFFHRLDE-SFLV--EEDKE---Y SKYPIFSNEK-EDKNYYDKYPTIYHLRKDLA
142

AKQ21048
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

WP_004636532
74
RRRNRLIYLQDIFQQPMLAIDENFFHRLDD-SFFV--PDDKS---Y DRHPIFGSLE-EEVAYHNTYPTIYHLRKHLA
143

WP_002364836
74
RRRNRLRYLQAFFEEAMTDLDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_016631044
25
RRRNRLRYLQAFFEEAMTDLDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
94

EMS75795

---------------------------------------------- -------------------------------

WP_002373311
74
RRRNRLRYLQAFFEEAMTDLDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_002378009
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_002407324
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_002413717
74
RRRNRLRYLQAFFEEAMTDLDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_010775580
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_010818269
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_010824395
74
RRRNRLRYLQAFFEEAMTDLDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_016622645
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_033624816
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_033625576
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_033789179
74
RRRNRLRYLQAFFEEAMTALDENFFARLQE-SFLV--PEDKK---W HRHPIFAKLE-DEVAYHETYPTIYHLRKKLA
143

WP_002310644
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SFLV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002312694
74
RRRQRILELOKIFAPEILKIDEHFFARLNE-SELV--PDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002314015
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SELV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002320716
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SFLV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002330729
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SELV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002335161
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SFLV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_002345439
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SFLV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_034867970
74
RRKYRLSKLQDLFAEELCKQDDCFFVRLEE-SFLV--PEEKQ---Y KPASIFPTLE-EEKEYYQKYPTIYHLRQKLV
143

WP_047937432
74
RRRQRILELQKIFAPEILKIDEHFFARLNE-SFLV--LDEKK---Q SRHPVFATIK-QWKSYHQTYPTIYHLRQALA
143

WP_010720994
74
RRKYRLSKLQDLFAEELCKQDDCFFVRLEE-SFLV--PEEKQ---Y KPASIFPTLE-EEKEYYQKYPTIYHLRQKLV
143

WP_010737004
74
RRKYRLSKLQDLFAEELCKQDDCFFVRLEE-SFLV--PEEKQ---Y KPASIFPTLE-EEKEYYQKYPTIYHLRQKLV
143

WP_034700478
74
RRKYRLSKLQDLFAEELCKQDDCFFVRLEE-SFLV--PEEKQ---Y KPASIFPTLE-EEKEYYQKYPTIYHLRQKLV
143

WP_007209003
74
RRKNRICYLQEIFQPEMNHLDNNFFYRLNE-SFLVa--DDAK---Y DKHPIFGTLD-EEIHGHEQFPTIYHLRKYLA
143

WP_023519017
74
RRRQRVLALQDIFAEEIHKKDPNFFARLEE-GDRV--EADKR---F AKFPVFATLS-EEKNYHRQYPTIYHLRHDLA
143

WP_010770040
74
RRRNRICRLQDLFTEEMNQVDANFFHRLQE-SFLV--PDEKE---F ERHAIFGKME-EEVSYYREFPTIYHLRKHLA
143

WP_048604708
74
RRRQRISYLQTFFQEEMNRIDPNFFNRLDE-SFLI--EEDKL---S ERHPIFGTIE-EEVAYHKNYATIYHLRKELA
143

WP_010750235
74
RRKYRILELQKIFSEEILKKDSHFFARLDE-SFLI--PEDKQ---Y ARFPIFPTLL-EEKAYYQNYPTIYHLRQKLA
143

AII16583
113
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
182

WP_029073316
66
KRRERIRLLRGIMEDMVLDVDPTFFIRLANVSFLD--QEDKKdylK SNYNLFIDKDfNDKTYYDKYPTIYHLRKHLC
144

WP_031589969
66
KRRERIRLLREIMEDMVLDVDPTFFIRLANVSFLD--QEDKKdylK DVYPIFGKRE-EELLYHDTHKTIYHLRSELA
144

KDA45870
75
RRKNRLRYLQEIFAPALAKVDPNFFYRLEE-SSLVa--EDKK---Y DVYPIFGKRE-EELLYHDTHKTIYHLRSELA
144

WP_039099354
62
RRKWRLGLLREIFEPYITPVDDTFFLRKKQ-SNLS--PKDQR---K -QTSLFNDRT--DRAFYDDYPTIYHLRYKLM
132

AKP02966
65
RRKNRINWLNEIFSEELANTDPSFLIRLON-SWVSkkDPDRK---R DKYNLFIDNPyTDKEYYREFPTIFHLRKELI
137

WP_010991369
74
RRRNRISYLQGIFAEEMSKTDANFFCRLSD-SFYV--DNEKR---N SRHPFFATIE-EEVEYHKNYPTIYHLREELV
143

WP_033838504
74
RRRNRISYLQGIFAEEMSKTDANFFCRLSD-SFYV--DNEKR---N SRHPFFATIE-EEVEYHKNYPTIYHLREELV
143

EHN60060
77
RRRNRISYLQGIFAEEMSKTDANFFCRLSD-SFYV--DNEKR---N SRHPFFATIE-EEVEYHKNYPTIYHLREELV
146

EFR89594

---------------------------------------------- -------------------------------

WP_038409211
74
RRRNRIAYLQEIFAAEMAEVDANFFYRLED-SFYI--ESEKR---H SRHPFFATIE-EEVAYHEEYKTIYHLREKLV
143

EFR95520

---------------------------------------------- -------------------------------

WP_003723650
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHDNYRTIYHLREKLV
143

WP_003727705
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_003730785
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_003733029
74
RRRNRISYLQEIFAIQMNEVDDNFFNRLKE-SFYA--ESDKK---Y NRHPFFGTVE-EEVAYYKDFPTIYHLRKELI
143

WP_003739838
74
RRRNRISYLQEIFALEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_014601172
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_023548323
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_031665337
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

WP_031669209
74
RRRNRISYLQEIFAIQMNEVDDNFFNRLKE-SFYA--ESDKK---Y NRHPFFGTVE-EEVAYYKDFPTIYHLRKELI
143

WP_033920898
74
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
143

AKI42028
77
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
146

AKI50529
77
RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV--DSEKR---N SRHPFFATIE-EEVAYHKNYRTIYHLREELV
146

EFR83390

---------------------------------------------- -------------------------------

WP_046323366
74
RRRNRISYLQEIFTAEMFEVDANFFYRLED-SFYI--ESEKR---Q SRHPFFATIE-EEVAYHENYRTIYHLREKLV
143

AKE81011
90
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
159

CUO82355
65
KRRERIRLLRAILQDMVLEKDPTFFIRLEHtSFLD--EEDKAky1G DNYNLFIDEDANDYTYYHKYPTIYHLRKALC
143

WP_033162887
66
KRRERIRLLRDLLGDMVMEVDPTFFIRLLNVSFLD--EEDKQkn1G DNYNLFIEKDfNDKTYYDKYPTIYHLRKELC
144

AGZ01981
107
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
176

AKA60242
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

AKS40380
74
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
143

4UN5_B
78
RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV--EEDKK---H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV
147

WP_010922251
144

embedded image

211

WP_039695303
145
DSSEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKI--FADFVGVYNRT--FDDS-H LSEITVDVA---SI
212

WP_045635197
144
DSKEKTDLRLIYLALAHMIKYRGHFLYEEA-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LSGQNAQVE---AI
211

5AXW_A
105
EEEFSA-------ALLHLAKRRG---VHNV------NEVE------------EDT----GN-- --------E-----
134

WP_009880683

--------------------------------------------------------------- --------------

WP_010922251
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_011054416
144
DSTDKVDLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_011284745
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_011285506
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_011527619
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_012560673
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_014407541
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQIYNQL--FEEN-- INASRVDAK---AI
211

WP_020905136
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_023080005
144
DSTDKVDLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_023610282
144
DSTDKVDLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_030125963
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_030126706
144
DSTDKVDLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_031488318
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_032460140
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_032461047
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGG-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_032462016
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INANGVDAK---AI
211

WP_032462936
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_032464890
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_033888930
1
---------------------------------PDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
36

WP_038431314
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_038432938
144
DSTDKVDLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_038434062
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

BAQ51233
55
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
122

KGE60162

--------------------------------------------------------------- --------------

KGE60856

--------------------------------------------------------------- --------------

WP_002989955
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_003030002
144
DISQKADLRLVYLALAHMIKFRGHFLIEGQ-LKAENTNVQAL--FKDFVEVYDKT--VEES-H LSEMTVDAL---SI
211

WP_003065552
147
DSSEKADLRLVYLALAHMIKERGHFLIEGE-LNAENTDVQKI--FADFVGVYDRT--FDDS-H LSEITVDAA---SI
214

WP_001040076
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQDVDVE---AI
212

WP_001040078
144
DKQEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-H LLSQNVDVE---AI
212

WP_001040080
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNIT--FENN-D LLSQNVDVE---AI
212

WP_001040081
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTI--FENN-D LLSQNVDVE---AI
212

WP_001040083
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040085
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040087
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040088
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040089
144
DKKEKADLRLIYIALAHIIKERGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040090
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040091
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040092
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTS--FENN-H LLSQNVDVE---AI
212

WP_001040094
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040095
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040096
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040097
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040098
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040099
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040100
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_001040104
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040105
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_001040106
144
DKKEKANLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_001040107
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDIT--FENN-H LLSQNIDVE---GI
212

WP_001040108
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_001040109
144
DKKEKANLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_001040110
144
DKKEKANLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDIT--FENN-H LLSQNIDVE---GI
212

WP_015058523
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTS--FENN-H LLSQNVDVE---AI
212

WP_017643650
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_017647151
144
DKKEKADLRLFYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDIE---GI
212

WP_017648376
144
DKKEKADLRLFYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_017649527
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_017771611
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_017771984
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

CFQ25032
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

CFV16040
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

KLJ37842
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

KLJ72361
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

KLL20707
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

KLL42645
144
DKKEKANLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_047207273
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_047209694
144
DKKEKADLRLIYLALAHIIKFRGHFLIEDDsFDVRNTDIQKQ--YQAFLEIFDTT--FENN-D LLSQNVDVE---AI
212

WP_050198062
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_050201642
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_050204027
144
DKKEKANLRLVYLALAHIIKFRGHFLIEDDsFDVRNTDIQRQ--YQAFLEIFDTT--FENN-H LLSQNIDVE---GI
212

WP_050881965
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

WP_050886065
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

AHN30376
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTS--FENN-H LLSQNVDVE---AI
212

EAO78426
144
DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ--YQDFLEIFNTT--FENN-D LLSQNVDVE---AI
212

CCW42055
144
DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ--YQAFLEIFDTT--FENN-H LLSQNVDVE---AI
212

WP_003041502
144
DISQKADLRLVYLALAHMIKFRGHFLIEGQ-LKAENTNVQAL--FKDFVEVYDKT--VEES-H LSEITVDAL---SI
211

WP_037593752
145
NSKEKADLRLVYLALAHMIKFRGHFLYEGD-LKAENTDVQAL--FKDFVEEYDKT--IEES-H LSEITVDAL---SI
212

WP_049516684
145
DISQKADLRLVYLALAHMIKFRGHFLIEGQ-LKAENTNVQAL--FKDFVEVYDKT--VEES-H LSEMTVDAL---SI
212

GAD46167
144
NSKEKADLRLVYLALAHMIKFRGHFLYEGD-LKAENTDVQAL--FKDFVEEYDKT--IEES-H LSEITVDAL---SI
211

WP_018363470
145
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FTDFVGVYDRT--FDDS-H LSEITVDAA---SI
212

WP_003043819
144
DSPEKADLRLIYLALAHIIKFRGHFLIEGK-LNAENSDVAKL--FYQLIQTYNQL--FEES-- LDEIEVDAK---GI
211

WP_006269658
144
DTSKKADLRLVYLALAHMIKFRGHFLYEGD-LKAENTDVQAL--FKDFVEEYDKT--IEES-H LSEITVDAL---SI
211

WP_048800889
144
DSTGKVDLRLVYLALAHMIKFRGHFLIEGQ-LKAENTDVQTL--FNDFVEVYDKT--IEES-H LAEITVDAL---SI
211

WP_012767106
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDMDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_014612333
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEK-- INASGVDAK---AI
211

WP_015017095
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDMDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_015057649
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDMDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_048327215
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDMDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_049519324
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASRVDAK---AI
211

WP_012515931
144
DNPQKADLRLIYLAVAHIIKFRGHFLIEGT-LSSKNNNLQKS--FDHLVDTYNLL--FEEQ-- LLTEGINAK---EL
211

WP_021320964
144
DNPQKADLRLIYLAVAHIIKFRGHFLIEGT-LSSKNNNLQKS--FDHLVDTYNLL--FEEQ-- LLTEGINAK---EL
211

WP_037581760
144
DNPQKADLRLIYLAVAHIIKFRGHFLIEGT-LSSKNNNLQKS--FDHLVDTYNLL--FEEQ-- LLTEGINAK---EL
211

WP_004232481
144
DSPEKVDLRLVYLALAHMIKFRGHFLIEGQ-LNAENTDVQKI--FADFVGVYDRT--FDDS-H LSEITVDAA---SI
211

WP_009854540
145
DSSEKADLRLVYLALAHMIKYRGHFLIEGK-LNAENTDVOKL--FTDFVGVYDRT--FDDS-H LSEITVDVA---ST
212

WP_012962174
145
DSHEKADLRLIYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FEAFVEVYDRT--FDDS-N LSEITVDAS---SI
212

WP_039695303
145
DSSEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVOKI--FADFVGVYNRT--FDDS-H LSEITVDVA---SI
212

WP_014334983
144
DSQEKADLRLVYLALAHMIKYRGHFLIEGE-LNAENTDVQKL--FNVFVETYDKI--VDES-H LSEIEVDAS---SI
211

WP_003099269
144
DSDQKADLRLIYLALAHIIKFRGHFLIEGN-LDSENTDVHVL--FLNLVNIYNNL--FEED-- VETASIDAE---KI
211

AHY15608
144
DSDQKADLRLIYLALAHIIKFRGHFLIEGN-LDSENTDVHVL--FLNLVNIYNNL--FEED-- VETASIDAE---KI
211

AHY17476
144
DSDQKADLRLIYLALAHIIKFRGHFLIEGN-LDSENTDVHVL--FLNLVNIYNNL--FEED-- VETASIDAE---KI
211

ESR09100

--------------------------------------------------------------- --------------

AGM98575
144
DSDQKADLRLIYLALAHIIKFRGHFLIEGN-LDSENTDVHVL--FLNLVNIYNNL--FEED-- VETASIDAE---KI
211

ALF27331
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_018372492
144
DTPDKMDIRLIYLALAHIIKYRGHFLIEGD-LDIENIGIQDS--FKSFIEEYNTQ--FGTK-- -LDSTTKVE---AI
209

WP_045618028
145
DSKEKADFRLIYLALAHIIKYRGHFLYEES-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LNGQNAQVE---AI
212

WP_045635197
144
DSKEKTDLRLIYLALAHMIKYRGHFLYEEA-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LSGQNAQVE---AI
211

WP_002263549
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002263887
144
DNPEKVDLRLVYLALAHIIKERGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002264920
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_002269043
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002269448
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002271977
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002272766
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002273241
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002275430
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002276448
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002277050
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_002277364
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002279025
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002279859
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_002280230
144
DNPEKVDLRLVYLALAHIIKERGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---E1
211

WP_002281696
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002282247
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_002282906
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002283846
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002287255
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002288990
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002289641
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002290427
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002295753
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002296423
144
DNPEKTDLRLVYLALAHIIKFGGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002304487
144
NSTEKADLRLVYLSLAHMIKFRGHFLIEGQ-LKAENTNVQAL--FKDFVEVYDKT--VEES-H LSEMTVDAL---SI
211

WP_002305844
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002307203
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQKL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002310390
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_002352408
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_012997688
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_014677909
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019312892
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019313659
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019314093
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQKL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019315370
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019803776
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_019805234
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_024783594
144
DNPEKVDLRLVYLALAHIIKERGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_024784288
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_024784666
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_024784894
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_024786433
144
DSTEKADLRLVYLALAHMIKFRGHFLIEGE-LNAENTDVQKL--FADFVGVYDRT--FDDS-H LSEITVDAS---SI
211

WP_049473442
144
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVORL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

WP_049474547
144
DNPEKTDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
211

EMC03581
137
DNPEKVDLRLVYLALAHIIKFRGHFLIEGK-FDTRNNDVQRL--FQEFLAVYDNT--FENS-S LQEQNVQVE---EI
204

WP_000428612
145
DSKEKTDLRLIYLALAHMIKYRGHFLYEDT-FDIKNNDIQKI--FNEFISIYNNT--FEGN-S LSGQNVQVE---AI
212

WP_000428613
145
DSKEKTDLRLIYLALAHMIKYRGHFLYEDT-FDIKNNDIQKI--FSEFISIYDNT--FEGS-S LSGQNAQVE---AI
212

WP_049523028
144
DSKEKVDLRLIYLALAHIIKYRGHFLYEDS-FDIKNNDIQKI--FNEFTILYDNT--FEES-S LSKGNAQVE---EI
211

WP_003107102
113
DSDEKADLRLIYLALAHIIKFRGHFLIEGD-LDSQNTDVNAL--FLKLVDTYNLM--FEDD-- IDTQTIDAT---VI
180

WP_054279288
146
DNTEKADLRLIYLALAHIIKFRGHFLIEGA-LSANNTDVQQL--VHALVDAYNIM--FEED-- LDIEAIDVK---AI
213

WP_049531101
145
DSKEKADLRLIYLTLAHMIKYRGHFLYEES-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LSGQNAQVE---AI
212

WP_049538452
145
DSKEKADLRLIYLALAHMIKYRGHFLYEEA-FDIKNNDIQKI--FNEFINIYDNT--FEGS-S LSGONEQVE---AI
212

WP_049549711
145
DSKEKADLRLIYLVLAHMIKYRGHFLYEEA-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LSGQNAQVE---TI
212

WP_007896501
146
DRDQKADLRLIYLALSHIIKFRGHFLIEGK-LNSENTDVQKL--FIALVTVYNLL--FEEE-- IAGETCDAK---AL
213

ERF44625
98
DRDQKADLRLIYLALSHIIKFRGHFLIEGK-LNSENTDVQKL--FIALVTVYNLL--FEEE-- IAGETCDAK---AL
165

WP_002897477
144
DSKEKSDVRLIYLALAHMIKYRGHFLYEET-FDIKNNDIQKI--FNEFINIYDNT--FEGS-S LSGQNAQVE---AI
211

WP_002906454
144
DSKEKTDLRLIYLALAHMIKYRGHFLYEES-FDIKNNDIQKI--FNEFISIYDNT--FEGS-S LSGQNAQVE---AI
211

WP_009729476
145
DSKEKTDLRLIYLALAHMIKYRGHFLYEEA-FDIKNNDIQKI--FNEFISIYNNT--FEGN-S LSGQNVQVE---AI
212

CQR24647
144
DSSEKADLRLVYLALAHIIKYRGHFLIDEP-IDIRNMNSQNL--FKEFLLAFDGI--QVDC-Y LASKHTDIS---GI
211

WP_000066813
145
DSKEKTDLRLIYLALAHMIKYRGHFLYEES-FDIKNNDIQKI--FSEFISIYDNT--FEGK-S LSGQNAQVE---AI
212

WP_009754323
145
DSKEKADLRLIYLALAHITKYRGHFLYEEA-FDIKNNDIQKI--FNEFINIYDNT--FEGS-S LSGONAQVE---AI
212

WP_044674937
144
DSSQKADIRLIYLALAHIIKYRGHFLFEGD-LKSENKDVQHL--FNDFVEMFDKY--VEGS-Y LSENLPNVA---DV
211

WP_044676715
144
DSSQKADIRLIYLALAHIIKYRGHFLFEGD-LKSENKDVQHL--FNDFVEMFDKT--VEGS-Y LSENLPNVA---DV
211

WP_44680361
144
DSSQKADIRLIYLALAHIIKYRGHFLFEGD-LKSENKDVQHL--FNDFVEMFDKT--VEGS-Y LSENLPNVA---DV
211

WP_044681799
144
DSSQKADIRLIYLALAHIIKYRGHFLFEGD-LKSENKDVQHL--FNDFVEMFDKT--VEGS-Y LSENLPNVA---DV
211

WP_049533112
144
DISQKADLRLVYLALAHMIKFRGHFLIEGQ-LKAENTNVQAL--FKDFVEVYDKT--VEES-H LSEMTVDAL---SI
211

WP_029090905
101
SQHRQFDIREVYLAIHHLIKYRGHFIYEDQtFTTDGNQLQHH--IKAIITMINSTl---NR-- IIPETIDINvfeKI
171

WP_006506696
140
ESTEKADPRLIYLALHHIVKYRGNFLYEGQkFNMDASNIEDK--LSDIFTQFTSFnnIPYEdD --KKNLEIL---EI
210

AIT42264
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_034440723
143
DSNQKADLRLIYLALAHMIKYRGHFLIEGD-LKMDFISISES--FQEFIDSYNEVcaLEDE-N NDELLTQIE---NI
217

AKQ21048
144
DSTDKADLRLIYLALAHMIKFRGHLFIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

WP_004636532
144
DNPEKADLRLVYTALAHIVKYRGHFLIEGE-LNTENTSISET--FEQFLDTYDSI--FKEQ-- LVGDISKVE---EI
210

WP_002364836
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_016631044
95
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENTSVKDQ--FQQFMVIYNQT--FVNGeS PLPESVLIE---EE
168

EMS75795

--------------------------------------------------------------- --------------

WP_002737311
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENTSVKDQ--FQQFMVIYNQT--FVNGeS PLPESVLIE---EE
217

WP_002378009
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_002407324
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_002413717
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_010775580
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_010818269
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_010824395
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENTSVKDQ--FQQFMVIYNQT--FVNGeS PLPESVLIE---EE
217

WP_016622645
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEK--FQOFMIIYNQT--FVNGeG PLPESVLIE---EE
217

WP_033624816
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKDQ--FQQFMVIYNQT--FVNGeS PLPESVLIE---EE
217

WP_033625576
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQOFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_033789179
144
DSSEQADLRLIYLALAHIVKYRGHFLIEGK-LSTENISVKEQ--FQQFMIIYNQT--FVNGeS PLPESVLIE---EE
217

WP_002310644
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_002312694
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-G KLDEAVDCS---FV
216

WP_002314015
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_002320716
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FROFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_002330729
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_002335161
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_002345439
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_034867970
144
DSTEKEDLRLVYLALAHLLKYRGHELFEGD-LDTENTSIEES--FRVFLEQYSKQ--SDOP-- -LIVHQPVL---TI
209

WP_047937432
144
DSSEKADIRLVYLAMAHLLKYRGHFLIEGE-LNTENSSVTET--FRQFLSTYNQQ--FSEA-D KLDEAVDCS---FV
216

WP_010720994
144
DSTEKGDLRLVYLALAHLLKYRGHELFEGD-LDTENTSIEES--FRVFLEQYGKQ--SDQP-- -LIVHQPVL---TI
209

WP_010737004
144
DSTEKEDLRLVYLALAHLLKYRGHFLFEGD-LDTENTSIEES--FRVFLEQYSKQ--SDQP-- -LIVHQPVL---TI
209

WP_034700478
144
DSTEKEDLRLVYLALAHLLKYRGHELFEGD-LDTENTSIEES--FRVFLEQYGKQ--SDQP-- -LIVHQPVL---TI
209

WP_007209003
144
DGDEKADLRLVYLAIAHIIKFRGNFLIEGE-LNTENNSVIELs--KVFVQLYNQT1-SELE-- FIDESIDES---EV
214

WP_023519017
144
NSKEQADIRLVYLAIAHCLKYRGHFLFEGE-LDTENTSVTEN--YQQFLQAYQQF--FPEP-- -IGDLDDAV---PI
209

WP_010770040
144
DTSEQADLRLVYLALAHIVKYRGHFLIEGE-LNTENSSVSET--FRTFIQVYNQI--FRENe- PLAVPDNIE---EL
212

WP_048604708
144
DAEEKADLRLVYLALAHIIKYRGHFLIEGR-LSTENTSTEET--FKTFLQKYNQT--FN---- PVDETISIG---SI
208

WP_010750235
144
DSTEKADIRLVYLALAHMIKYRGHFLFEGE-LDTENTSVEET--FKEFIDIYNEQ--FEEG-- -IIFYKDIP---LI
209

AII16583
183
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
250

WP_029073316
145
ESKEKEDPRLIYLALHHIVKYRGNFLYEGQKFSMDVSNIEDK--MIDVLRQFNEIn1FEYVeD --KKIDEVL---NV
215

WP_031589969
145
ESKEKEDPRLIYLALHHIVKYRGNFLYEGQKFSMDVSNIEDK--MIDVLRQFNEIn1FEYVeD --KKIDEVL---NV
215

KDA45870
145
NNDRPADLRLVYLALAHIIKYRGNFLLEGE-IDLRTTDINKV--FAEFSETLNEN--SDENIG ----KLDVA---DI
209

WP_039099354
133
TEKRQFDIREIYLAMHHIVKYRGHFLNEAPvSSFKSSEINLVahFDRLNTIFADL--FSESgF -TDKLAEVK---AL
206

AKP02966
138
INKNKADIRLVYLALHNILKYRGNFTYEHQkFNISTLNSNLS---KELIELNQQLikYDIS-- -FPDNCDWNhisDI
208

WP_010991369
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTQNTSVDGI--YKQFIQTYNQV--FASGIE KLEDNKDVA---KI
217

WP_033838504
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTQNTSVDGI--YKQFIQTYNQV--FASGIE KLEDNKDVA---KI
217

EHN60060
147
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTQNTSVDGI--YKQFIQTYNQV--FASGIE KLEDNKDVA---KI
220

EFR89594

--------------------------------------------------------------- --------------

WP_038409211
144
NSSDKADLRLVYLALAHIIKYRGNFLIEGM-LDTKNTSVDEV--FKQFIQTYNQI--FASDIE RLEENKEVA---EI
217

EFR95520

--------------------------------------------------------------- --------------

WP_003723650
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDEV--YKQFIETYNQV--FMSNIE KVEENIEVA---NI
217

WP_003727705
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDEV--YKQFIQTYNQV--FMSNIE KVEENTEVA---SI
217

WP_003730785
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDEV--YKQFIQTYNQV--FMSNIE KVEENTEVA---SI
217

WP_003733029
144
DSQKKADLRLVYLALAHIIKYRGHFLIEGA-LDTKNTSIDEM--FKQFLQIYNQV--FANDIE KTEKNQEVA---QI
217

WP_003739838
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YKQFIQTYNQV--FISNIE KMEENTTVA---DI
217

WP_014601172
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFIQTYNQV--FMSNIE KVEENIEVA---NI
217

WP_023548323
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFILTYNQV--FMSNIE KVEENIEVA---NI
217

WP_031665337
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFIQTYNQV--FMSNIE KVEENIEVA---NI
217

WP_031669209
144
DSQKKADLRLVYLALAHIIKYRGHFLIEGA-LDTKNTSIDEM--FKQFLQIYNQV--FANDIE KTEKNQEVA---QI
217

WP_033920898
144
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFIQTYNQV--FMSNIE KVEENIEVA---NI
217

AKI42028
147
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFIQTYNQV--FMSNIE KVEENIEVA---NI
220

AKI50529
147
NSSEKADLRLVYLALAHIIKYRGNFLIEGA-LDTKNTSVDGV--YEQFIQTYNQV--FMSNIE KVEENIEVA---NI
220

EFR83390

--------------------------------------------------------------- --------------

WP_046323366
144
NSSDKADLRLVYLALAHIIKYRGNFLIEGK-LDTKNTSVDEV--FKQFIKTYNQV--FASDIE RIEENNEVA---KI
217

AKE81011
160
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
227

CUO82355
144
ESTEKADPRLIYLALHHIVKYRGNFLYEGQKFNMDASNIEDK--LSDVFTQFADFnnIPYEdD --KKNLEIL---EI
214

WP_033162887
145
ENKEKADPRLIYLALHHIVKYRGNFLYEGQSFTMDNSDIEER--LNSAIEKFMSIneFDNRiV --SDINSMI---AV
215

AGZ01981
177
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
244

AKA60242
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

AKS40380
144
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
211

4UN5_B
148
DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL--FIQLVQTYNQL--FEEN-- INASGVDAK---AI
215

WP_010922251
212

embedded image

277

WP_039695303
213
LTEK-ISKSRRLENLIKY-Y-PT EKKNTLFGNLIALALGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
278

WP_045635197
212
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEDK-A---PLQ--FSKDTYDEDLEN
277

5AXW_A
135
LSTK--------EQISRN-S--K ----------------------------LEEKyVa--ELQ--------------
157

WP_009880683

--------------------------------------------------------------- --------------

WP_010922251
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_011054416
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_011284745
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_011285506
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_011527619
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_012560673
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_014407541
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_020905136
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_023080005
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_023610282
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_030125963
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_030126706
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_031488318
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_032460140
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_032461047
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_032462016
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALLLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_032462936
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_032464890
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_033888930
37
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
102

WP_038431314
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-T---KLQ--LSKDTYDDDLDN
277

WP_038432938
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_038434062
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

BAQ51233
123
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
188

KGE60162

--------------------------------------------------------------- --------------

KGE60856

--------------------------------------------------------------- --------------

WP_002989955
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNTLFGNLIALALGLOPNFKMNF--KLSED-A---KLQ--FSKDSYEEDLGE
277

WP_003030002
212
LTEK-VSKSRRLENLIAH-Y-PA QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
277

WP_003065552
215
LTEK-ISKSRRLENLIKY-Y-PT QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
280

WP_001040076
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040078
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040080
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040081
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040083
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040085
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040087
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040088
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040089
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040090
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040091
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040092
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040094
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040095
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040096
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040097
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040098
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040099
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040100
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040104
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040105
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040106
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040107
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040108
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040109
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_001040110
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_015058523
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017643650
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017647151
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017648376
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017649527
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017771611
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_017771984
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

CFQ25032
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

CFV16040
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

KLJ37842
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

KLJ72361
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

KLL20707
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

KLL42645
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_047207273
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_047209694
213
LTDK-ISKSAKKDRILAR-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_050198062
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_050201642
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_050204027
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_050881965
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_050886065
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

AHN30376
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

EAO78426
213
LTDK-ISKSAKKDRILAQ-Y-PN QKSTGIFAEFLKLIVGNQADFKKYF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

CCW42055
213
LTDK-ISKSAKKDRILAQ-Y-PD QKSTGIFAEFLKLIVGNQADFKKHF--NLEDK-T---PLQ--FAKDSYDEDLEN
278

WP_003041502
212
LTEK-VSKSRRLENLIAH-Y-PA EKKNTLFGNLIALFLGLQPNFKTNF--QLSED-A---KLQ--FSKDTYEEDLEG
277

WP_037593752
213
LTEK-VSKSSRLENLIAH-Y-PT EKKNTLFGNLIALSLGLQPNFKINF--QLSED-A---KLQ--FSKDTYEEDLEE
278

WP_049516684
213
LTEK-VSKSRRLENLVEC-Y-PT EKKNTLFGNLIALSLGLQPNFKINF--QLSED-A---KLQ--FSKDTYEEDLEG
278

GAD46167
212
LTEK-VSKSSRLENLIAH-Y-PT EKKNTLFGNLIALSLGLQPNFKTNF--QLSED-A---KLQ--FSKDTYEEDLEE
277

WP_018363470
213
LTEK-ISKSRRLENLINN-Y-PK EKKNTLFGNLIALALGLOPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
278

WP_003043819
212
LSAR-LSKSKRLEKLIAV-F-PN EKKNGLFGNIIALALGLTPNFKSNF--DLTED-A---KLQ--LSKDTYDDDLDE
277

WP_006269658
212
LTEK-VSKSSRLENLIAH-Y-PT EKKNTLFGNLIALSLDLHPNFKINF--QLSED-A---KLQ--FSKDTYEEDLEG
277

WP_048800889
212
LTEK-VSKSRRLENLVKC-Y-PT EKKNTLFGNLIALSLGLOPNFKTNF--QLSED-A---KLQ--FSKDTYEEDLEE
277

WP_012767106
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_014612333
212
LSAR-LSKSKRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_015017095
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_015057649
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_048327215
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLIPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_049519324
212
LSAR-LSKSRRLENLIAQ-L-PG EKRNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_012515931
212
LSAA-LSKSKRLENLISL-I-PG QKKTGIFGNIIALSLGLTPNFKANF--GLSKD-V---KLQ--LAKDTYADDLDS
277

WP_021320964
212
LSAA-LSKSKRLENLISL-I-PG QKKTGIFGNIIALSLGLTPNFKANF--GLSKD-V---KLQ--LAKDTYADDLDS
277

WP_037581760
212
LSAA-LSKSKRLENLISL-I-PG QKKTGIFGNIIALSLGLTPNFKANF--GLSKD-V---KLQ--LAKDTYADDLDS
277

WP_004232481
212
LTEK-ISKSRRLENLIKQ-Y-PT EKKNTLFGNLVALALGLQPNFKTNF--KLSED-A---KLQ--FSKDTYDEDLEE
277

WP_009854540
213
LTEK-ISKSRRLENLIKY-Y-PT EKKNTLFGNLIALALGLQPNFKMNF--KLSED-A---KLQ--FSKDTYEEDLEE
278

WP_012962174
213
LTEK-FSKSRRLENLIKH-Y-PT EKKNTLFGNLVALALGLQPNFKTSF--KLSED-A---KLQ--FSKDTYEEDLEE
278

WP_039695303
213
LTEK-ISKSRRLENLIKY-Y-PT EKKNTLFGNLIALALGLOPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
278

WP_014334983
212
LTEK-VSKSRRLENLIKQ-Y-PT EKKNTLFGNLIALALGLQPNFKINF--KLSED-A---KLQ--FSKDIYEEDLEE
277

WP_003099269
212
LTSK-TSKSRRLENLIAE-I-PN QKRNMLFGNLVSLALGLTPNFKTNF--ELLED-A---KLQ--ISKDSYEEDLDN
277

AHY15608
212
LTSK-TSKSRRLENLIAE-I-PN QKRNMLFGNLVSLALGLTPNFKTNF--ELLED-A---KLQ--ISKDSYEEDLDN
277

AHY17476
212
LTSK-TSKSRRLENLIAE-I-PN QKRNMLFGNLVSLALGLTPNFKTNF--ELLED-A---KLQ--ISKDSYEEDLDN
277

ESR09100

----------------------- ------------------------------------------------------

AGM98575
212
LTSK-TSKSRRLENLIAE-I-PN QKRNMLFGNLVSLALGLTPNFKTNF--ELLED-A---KLQ--ISKDSYEEDLDN
277

ALF27331
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_018372492
210
FTEN-SSKAKRVETILGL-F-PD ETAAGNLDKFLKLMLGNQADFKKVF--DLEEK----iTLQ--FSKDSYEEDLEL
275

WP_045618028
213
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEDLEN
278

WP_045635197
212
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEDK-A---PLQ--FSKDTYDEDLEN
277

WP_002263549
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002263887
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002264920
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFRNLVALSLGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
277

WP_002269043
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002269448
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002271977
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEDLEE
277

WP_002272766
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEDLEE
277

WP_002273241
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002275430
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002276448
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002277050
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFGNLIALSLGLQPNFKINF--KLSED-A---KLQ--FSKDTYEEDLEE
277

WP_002277364
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002279025
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002279859
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFGNLIALSLGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEELEV
277

WP_002280230
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002281696
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002282247
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFGNLIALSLGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
277

WP_002282906
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002283846
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002287255
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002288990
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002289641
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGCFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002290427
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002295753
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002296423
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002304487
212
LTEK-VSKSRRLENLVEC-Y-PT EKKNTLFGNLIALSLGLQPNFKTNF--QLSED-A---KLQ--FSKDTYEEDLEG
277

WP_002305844
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_002307203
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--LSKDTYEEELEV
277

WP_002310390
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_002352408
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_012997688
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_014677909
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_019312892
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_019313659
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIIGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_019314093
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--LSKDTYEEELEV
277

WP_019315370
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_019803776
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-V---PLQ--FSKDTYEEELEV
277

WP_019805234
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDIYEEELEV
277

WP_024783594
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_024784288
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFGNLIALSLGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
277

WP_024784666
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_024784894
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

WP_024786433
212
LTEK-ISKSRRLEKLINN-Y-PK EKKNTLFGNLIALSLGLQPNFKTNF--KLSED-A---KLQ--FSKDTYEEDLEE
277

WP_049473442
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEDLEE
277

WP_049474547
212
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
277

EMC03581
205
LTDK-ISKSAKKDRVLKL-F-PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK-A---PLQ--FSKDTYEEELEV
270

WP_000428612
213
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSRDTYDEDLEN
278

WP_000428613
213
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLGEK-A---PLQ--FSKDTYDEDLEN
278

WP_049523028
212
FTDK-ISKSAKRDRVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYEEDLES
277

WP_003107102
181
LTEK-MSKSRRLENLIAK-I-PN QKKNTLFGNLISLSLGLTPNFKANF--ELSED-A---KLQ--ISKESFEEDLDN
246

WP_054279288
214
LTEK-ISKTRRLENLISN-I-PG QKKNGLFGNLIALSLGLTPNFKSHF--NLPED-A---KLQ--LAKDTYDEELNN
279

WP_049531101
213
FTDK-ISKSTKRERVLKL-F-PD QKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEDLEN
278

WP_049538452
213
FSDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEDLEN
278

WP_049549711
213
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLGEK-A---PLQ--FSKDTYDEDLEN
278

WP_007896501
214
LTAK-TSKSKRLESLISE-F-PG QKKNGLFGNLLALALGLRPNFKSNF--GLSED-A---KLQ--ITKDTYEEELDN
279

EFR44625
166
LTAK-TSKSKRLESLISE-F-PG QKKNGLFGNLLALALGLRPNFKSNF--GLSED-A---KLQ--ITKDTYEEELDN
231

WP_002897477
212
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEELEN
277

WP_002906454
212
FTDK-ISKSTKRERVLKL-F-SD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEDLEN
277

WP_009729476
213
FTDK-ISKSAKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSRDTYDEDLEN
278

CQR24647
212
ITAK-ISKSRKVEAVLEQ-F-PD QKKNSFFGNMVSLVFGLMPNFKSNF--ELDED-A---KLQ--FSRDSYDEDLEN
277

WP_000066813
213
FTDK-ISKSTKRERVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---PLQ--FSKDTYDEDLEN
278

WP_009754323
213
FTGK-ISKSVKREHVLKL-F-PD EKSTGLFSEFLKLIVGNQADFKKHF--DLEEK-A---SLQ--FSKDTYDEDLEN
278

WP_044674937
212
LVEK-VSKSRRLENILHY-F-PN EKKNGLFGNFLALALGLQPNFKTNF--ELAED-A---KIQ--FSKETYEEDLEE
277

WP_044676715
212
LVEK-VSKSRRLENILHY-F-PN EKKNGLFGNFLTLALGLQPNFKTNF--ELAED-A---KIQ--FSKETYEEDLEE
277

WP_044680361
212
LVEK-VSKSRRLENILHY-F-PN EKKNGLFGNFLALALGLQPNFKINF--ELAED-A---KIQ--FSKETYEEDLEE
277

WP_044681799
212
LVEK-VSKSRRLENILHY-F-PN EKKNGLFGNFLALALGLQPNFKTNF--ELAED-A---KIQ--FSKETYEEDLEE
277

WP_049533112
212
LTEK-VSKSRRLENLIAH-Y-PA EKKNTLFGNLIALSLGLQPNFKINF--QLSED-A---KLQ--FSKDTYEEDLEG
277

WP_029090905
172
LLDRmMNRSSKVKFLIEL---TG KQDKPLLKELFNLIVGLKAKPASIFe---QEN1AtivETM-nMSTEQVOLDLLT
243

WP_006506696
211
LKKP-LSKKAKVDEVMTL-IaPE KDYKSAFKELVTGIAGNKMNVTKMIIcEPIKQ-Gds-EIK1kFSDSNYDDQFSE
283

AIT42264
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_034440723
218
FKQD-ISRSKKLDQAIAL-F-QG -KRQSLFGIFLTLIVGNKANFQKIF--NLEDD----IKLD--LKEEDYDENLEE
283

AKQ21048
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

WP_004636532
211
LSSK-QSRSRKHEQIMAL-F-PN ENKLGNFGRFMMLIVGNTSNFKPVF--DLDDE-Y---KLK--LSDETYEEDLDT
276

WP_002364836
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_016631044
169
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
234

EMS75795
1
----------------------- ----------------------------MDEE-A---KIQ--LSKESYEEELES
20

WP_002373311
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_002378009
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_002407324
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_002413717
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_010775580
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KIKitYASESYEEDLEG
285

WP_010818269
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_010824395
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_016622645
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_033624816
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_033625576
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_033789179
218
LTEK-ASRTKKSEKVLQQ-F-PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE-A---KI--tYASESYEEDLEG
283

WP_002310644
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EE-A---KLQ--FSKETYEEDLEE
281

WP_002312694
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_002314015
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_002320716
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_002330729
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EE-A---KLQ--FSKETYEEDLEE
281

WP_002335161
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_002345439
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_034867970
210
LTDK-LSKTKKVEEILKY-Y-PT EKINSFFAQCLKLIVGNQANFKRIF--DLEAE-V---KLQ--FSKETYEEDLES
275

WP_047937432
217
FTEK-MSKTKKAETLLKY-F-PH EKSNGYLSQFIKLMVGNQGNFKNVF--GL-EEeA---KLQ--FSKETYEEDLEE
282

WP_010720994
210
LTDK-LSKTKKVEEILKY-Y-PT EKINSFFAQCLKLIVGNQANFKRIF--DLEAE-V---KLQ--FSKETYEEDLES
275

WP_010737004
210
LTDK-LSKTKKVEEILKY-Y-PT EKINSFFAQCLKLIVGNQANFKRIF--DLEAE-V---KLQ--FSKETYEEDLES
275

WP_034700478
210
LTDK-LSKTKKVEEILKY-Y-PT EKINSFFAQCLKLIVGNQANFKRIF--DLEAE-V---KLQ--FSKETYEEDLES
275

WP_007209003
215
LTQQ-LSKSERADNVLKL-F-PD EKGTGIFAQFIKLIVGNQGNFKKVF--QLEED----qKLQ--LSTDDYEENIEN
280

WP_023519017
210
LTER-LSKAKRVEKVLAY-Y-PS EKSTGNFAQFLKLMVGNQANFKKTF--DLEEE-M---KLN--FTRDCYEEDLNE
275

WP_010770040
213
FSEK-VSRARKVEAILSV-Y-SE EKSTGTLAQFLKLMVGNQGRFKKTF--DLEED-G---IIQ--IPKEEYEEELET
278

WP_048604708
209
FADK-VSRAKKAEGVLAL-F-PD EKRNGTFDQFLKMIVGNQGNFKKTF--ELEED-A---KLQ--FSKEEYDESLEA
274

WP_010750235
210
LTDK-LSKSKKVEKILQY-Y-PK EKTTGCLAQFLKLIVGNQGNFKQAF--HLDEE-V---KIQ--ISKETYEEDLEK
275

AII16583
251
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
316

WP_029073316
216
LKEP-LSKKHKADKAFAL-FdTT KDNKAAYKELCAALAGNKFNVTKMLkeAELHD-EdekDISfkFSDATEDDAFVE
289

WP_031589969
216
LKEP-LSKKHKAEKAFAL-FdTT KDNKAAYKELCAALAGNKFNVTKMLkeAELHD-EdekDISfkFSDATFDDAFVE
289

KDA45870
210
FKDNtFSKTKKSEELLKL---SG -KKNQLAHQLFKMMVGNMGSFKKVL--GTDEE----hKLS--FGKDTYEDDLND
275

WP_039099354
207
LLDNhQSASNRORQALLLiYtPS KONKAIATELLKAILGLKAKFNVLT--GIEAEdVktwTLT--FNAENFDEEMVK
285

AKP02966
209
LIGR-GNATQKSSNILNN-F--T KETKKLLKEVINLILGNVAHLNTIFktSLTKDeE---KLS--FSGKDIESKLDD
278

WP_010991369
218
LVEK-VTRKEKLERILKL-Y-PG EKSAGMFAQFISLIVGSKGNFQKPF--DLIEK-S---DIE--CAKDSYEEDLES
283

WP_033838504
218
LVEK-VTRKEKLERILKL-Y-PG EKSAGMFAQFISLIVGSKGNFQKPF--DLIEK-S---DIE--CAKDSYEEDLES
283

EHN60060
221
LVEK-VTRKEKLERILKL-Y-PG EKSAGMFAQFISLIVGSKGNFQKPF--DLIEK-S---DIE--CAKDSYEEDLES
286

EFR89594
1
---------------LKL-Y-PG EKSTGMFAQFISLIVGSKGNFQKPF--DLIEK-S---DIE--CAKDSYEEDLES
52

WP_038409211
218
LSEK-LTRREKLDKILKL-Y-TG EKSTGMFARFINLIIGSKGDFKKVF--DLDEK-A---EIE--CAKDTYEEDLEA
283

EFR95520

----------------------- ------------------------------------------------------

WP_003723650
218
LAGK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLET
283

WP_003727705
218
LAGK-FTRREKFERILRL-Y-PG EKSTGMFAQFISLIVGNKGNFQKVF--NLVEK-T---DIE--CAKDSYEEDLEA
283

WP_003730785
218
LAGK-FTRREKFERILRL-Y-PG EKSTGMFAQFISLIVGNKGNFQKVF--NLVEK-T---DIE--CAKDSYEEDLEA
283

WP_003733029
218
LAEK-FTRKDKLDKILSL-Y-PG EKTTGVFAQFVNIIVGSTGKFKKHF--NLHEK-K---DIN--CAEDTYDTDLES
283

WP_003739838
218
LAGK-FTRKEKLERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLVEK-T---DIE--CAKDSYEEDLEA
283

WP_014601172
218
LAGK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLEA
283

WP_023548323
218
LAGK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLET
283

WP_031665337
218
LAGK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLET
283

WP_031669209
218
LAEK-FTRKDKLDKILSL-Y-PG EKTTGVFAQFVNIIVGSTGKFKKHF--NLHEK-K---DIN--CAEDTYDTDLES
283

WP_033920898
218
LARK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLET
283

AKI42028
221
LAGK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLEA
286

AKI50529
221
LARK-FTRREKFERILQL-Y-PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK-T---DIE--CAKDSYEEDLET
286

EFR83390

----------------------- ------------------------------------------------------

WP_046323366
218
FSEK-LTKREKLDKILNL-Y-PN EKSTDLFAQFISLIIGSKGNFKKFF--NLTEK-T---DIE--CAKDSYEEDLEV
283

AKE81011
228
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
293

CUO82355
215
LKKP-LSKKAKVDEVMAL-IsPE KEFKSAYKELVIGIAGNKMNVTKMIICESIKQ-Gds-EIK1kFSDSNYDDQFSE
287

WP_033162887
216
LSKI-YQRSKKADDLLKI-MnPT KEEKAAYKEFTKALVGLKFNISKMIlaQEVKK-Gdt-DIVleFSNANYDSTIDE
288

AGZ01981
245
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
310

AKA60242
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

AKS40380
212
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
277

4UN5_B
216
LSAR-LSKSRRLENLIAQ-L-PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-A---KLQ--LSKDTYDDDLDN
281

WP_010922251
278

embedded image

356

WP_039695303
279
LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKNK
357

WP_045635197
278
LLGQIGDDFTDLFVSAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHONDLAALKOFIKNN-LPEKYDEVESDQSK
356

5AXW_A
158
---------------------------------------------------------LERLKKDG-------EVR-----
168

WP_009880683
1
---------------------------------------LSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
40

WP_010922251
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHODLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_011054416
278
LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_011284745
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHODLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_011285506
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_011527619
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_012560673
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_014407541
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_020905136
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_023080005
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_023610282
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_030125963
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKASLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_030126706
278
LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_031488318
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_032460140
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_032461047
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_032462016
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_032462936
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_032464890
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_033888930
103
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLILLKALVRQQ-LPEKYKEIFFDQSK
181

WP_038431314
278
LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHODLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_038432938
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLILLKALVRQQ-LPEKYKEIFFDQSK
356

WP_038434062
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

BAQ51233
189
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
267

KGE60162

--------------------------------------------------------------------------------

KGE60856

--------------------------------------------------------------------------------

WP_002989955
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_003030002
278
LLGEIGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK
356

WP_003065552
281
LLGKIGDDYADLFTSAKNLYDAILLSGILIVDDNSTKAPLSASMIKRYVEHQEDLEKLKEFIKAN-KSELYHDIFKDKNK
359

WP_001040076
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIVADSSK
357

WP_001040078
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

WP_001040080
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040081
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

WP_001040083
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

WP_001040085
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040087
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

WP_001040088
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040089
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040090
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040091
279
LLRQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040092
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSAYMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040094
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQHYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040095
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040096
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040097
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040098
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

WP_001040099
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040100
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040104
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040105
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_001040106
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_001040107
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_001040108
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_001040109
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_001040110
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_015058523
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_017643650
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_017647151
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_017648376
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_017649527
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_017771611
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTALSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_017771984
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

CFQ25032
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKASLSDSMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFADSSK
357

CFV16040
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

KLJ37842
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

KLJ72361
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

KLL20707
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

KLL42645
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFTDSSK
357

WP_047207273
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_047209694
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_050198062
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_050201642
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_050204027
279
LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFTDSSK
357

WP_050881965
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_050886065
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKOFVKAS-LPEKYQEIFADSSK
357

AHN30376
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

EAO78426
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

CCW42055
279
LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKOLKQFVKAS-LPEKYQEIFADSSK
357

WP_003041502
278
LLGEVGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKFEDFIKVN-ALDQYNAIFKDKNK
356

WP_037593752
279
LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK
357

WP_049516684
279
LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APAQYDDIFKDETK
357

GAD46167
278
LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK
356

WP_018363470
279
LLGKIGDDYADLFTSSKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKTQ
357

WP_003043819
278
LLGQIGDQYADLFSAAKNLSDAILLSDILRSNSEVTKAPLSASMVKRYDEHHQDLALLKTLVRQQ-FPEKYAEIFKDDTK
356

WP_006269658
278
FLGEVGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK
356

WP_048800889
278
LLGKIGDDYADLFTSAKNLYDTILLSGILAVDDNSTKALLSASMIKRYEEHQKDLKKLKDFIKVN-APAQYDDIFKDETK
356

WP_012767106
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHODLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_014612333
278
LLAQIGNQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_015017095
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHODLTLLKALVROQ-LPEKYKEIFFDQSK
356

WP_015057649
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHODLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_048327215
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_049519324
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHODLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_012515931
278
LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK
356

WP_021320964
278
LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK
356

WP_037581760
278
LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK
356

WP_004232481
278
LLGKIGDDYADLFTAAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYEEHHEDLEKLKTFIKVN-NFDKYHEIFKDKSK
356

WP_009854540
279
LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKNK
357

WP_012962174
279
LIGKIGDEYADLFTSAKNLYDAILLSGILTVADNTTKAPLSASMIKRYNEHQVDLKKLKEFIKNN-ASDKYDEIFNDKDK
357

WP_039695303
279
LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKNK
357

WP_014334983
278
LLGKVGDDYADLFISAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKIN-KLKLYHDIFKDKTK
356

WP_003099269
278
LLAQIGDQYADLFIAAKKLSDAILLSDIITVKGASTKAPLSASMVORYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK
356

AHY15608
278
LLAQIGDQYADLFIAAKKLSDAILLSDIITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK
356

AHY17476
278
LLAQIGDQYADLFIAAKKLSDAILLSDIITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK
356

ESR09100

--------------------------------------------------------------------------------

AGM98575
278
LLAQIGDQYADLFIAAKKLSDAILLSDIITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK
356

ALF27331
278
LLAQIEDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_018372492
276
LLSKIDEEYAALFDLAKKVYDAVLLSNILTVKEKNTKAPLSASMIKRYEEHKDDLKAFKRFFRER-LPEKYETMFKDLTK
354

WP_045618028
279
LLVQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIDRYENHQKDLAALKOFIKTN-LPEKYDEVFSDQSK
357

WP_045635197
278
LLGQIGDDFTDLFVSAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHONDLAALKQFIKNN-LPEKYDEVFSDQSK
356

WP_002263549
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002263887
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002264920
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN-KPELYHDIFKDETK
356

WP_002269043
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002269448
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVFSDVSK
356

WP_002271977
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVFSDVSK
356

WP_002272766
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002273241
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002275430
278
LLTQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002276448
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002277050
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN-KPELYHDIFKDETK
356

WP_002277364
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002279025
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTADDSSTKAPLSASMIQRYNEHOMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002279859
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002280230
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIROK-LSDKYNEVFSDVSK
356

WP_002281696
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002282247
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN-KPELYHDIFKDETK
356

WP_002282906
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIROK-LSDKYNEVESDVSK
356

WP_002283846
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002287255
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002288990
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002289641
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTOLKQFIROK-LSDKYNEVESDVSK
356

WP_002290427
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002295753
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002296423
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKQFIRQK-LSDKYNEVFSDVSK
356

WP_002304487
278
LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYKEHKEELAAFKRFIKEK-LPKKYEEIFKDDTK
356

WP_002305844
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_002307203
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002310390
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_002352408
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVFSDVSK
356

WP_012997688
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVFSDVSK
356

WP_014677909
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIROK-LSDKYNEVFSDVSK
356

WP_019312892
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVFSDVSK
356

WP_019313659
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTQAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_019314093
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_019315370
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLTOLKQFIRQK-LSDKYNEVESDVSK
356

WP_019803776
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_019805234
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKOFIRQK-LSDKYNEVESDVSK
356

WP_024783594
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVFSDVSK
356

WP_024784288
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN-KPELYHDIFKDETK
356

WP_024784666
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHOMDLVOLKOFIRQK-LSDKYNEVFSDVSK
356

WP_024784894
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTOLKQFIRQK-LSDKYNEVESDVSK
356

WP_024786433
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN-KPELYHDIFKDETK
356

WP_049473442
278
LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-LSDKYNEVESDVSK
356

WP_049474547
278
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTQLKOFIRQK-LSDKYNEVFSDVSK
356

EMC03581
271
LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIROK-LSDKYNEVESDVSK
349

WP_000428612
279
LLGQIGDDFADLFVAAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLATLKQFIKTN-LPEKYDEVFSDQSK
357

WP_000428613
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAVLKQFIKNN-LPEKYDEVFSDQSK
357

WP_049523028
278
LLGQIGDVYADLFVVAKKLYDAILLAGILSVKDPGTKAPLSASMIERYDNHONDLSALKQFVRRN-LPEKYAEVFSDDSK
356

WP_003107102
247
LLAQIGDQYADLFIAAKNLSDAILLSDILTVKGVNTKAPLSASMVQRFNEHQDDLKLLKKLVKVQ-LPEKYKEIFDIKDK
325

WP_054279288
280
LLTQIGDEYADLFLSAKNLSDAILLSDILTVNGDGTQAPLSASLIKRYEEHRQDLALLKOMFKEQ-LPDLYRDVFTDENK
358

WP_049531101
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAALKQFIKNN-LPEKYDEVFSDQSK
357

WP_049538452
279
LLGQIGDGFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYQNHONDLASLKQFIKNN-LPEKYDEVFSDQSK
357

WP_049549711
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLTTLKQFIKNN-LPEKYDEVFSDQSK
357

WP_007896501
280
LLAEIGDHYADLFLAAKNLSDAILLSDILTLSDENTRAPLSASMIKRYEEHQEDLALLKKLVKEQ-MPEKYWEIFSNAKK
358

EFR44625
232
LLAEIGDHYADLFLAAKNLSDAILLSDILILSDENTRAPLSASMIKRYEEHQEDLALLKKLVKEQ-MPEKYWEIFSNAKK
310

WP_002897477
278
LLGQIGDDFADLFLIAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAALKQFIKNN-LPEKYVEVFSDQSK
356

WP_002906454
278
LLGQIGDGFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQEDLAALKQFIKNN-LSEKYAEVFSDQSK
356

WP_009729476
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVINPSTKAPLSASMIERYENHQKDLASLKQFIKNN-LPEKYDEVFSDQSE
357

COR24647
278
LLGIIGDEYADVFVAAKKVYDSILLSGILTTNNHSTKAPLSASMIDRYDEHNSDKKLLRDFIRTNIGKEVFKEVFYDTSK
357

WP_000066813
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVKDLSTKAPLSASMIERYENHOKDLAALKOFIQNN-LQEKYDEVESDQSK
357

WP_009754323
279
LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQEDLAALKQFIKNN-LPEKYAEVFSDQSK
357

WP_044674937
278
LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHKKDLALLKNFIHQN-LSDSYKEVENDKLK
356

WP_044676715
278
LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHQKDLALLKNFIHQN-LSDSYKEVENDKLK
356

WP_044680361
278
LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHQKDLALLKNFIHON-LSDSYKEVENDKLK
356

WP_044681799
278
LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHKKDLALLKNFIHQN-LSDSYKEVENDKLK
356

WP_049533112
278
LLGEIGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK
356

WP_029090905
244
LADVLADEEYDLLLTAQKIYSAIILDESMDGYEYFA-----EAKKESYRKHQEELVLVKKMLKSNaITNDERAKF---EY
315

WP_006506696
284
VEKDLGE-YVEFVDALHNVYSWVELQTIMGATHTD-NASISEAMVSRYNKIHDDLKLLKDCIKNN-VPNKYFDMERNDSE
360

AIT42264
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_034440723
284
LLSNIDEGYRDVFLQAKNVYNAIELSKILKTDGKETKAPLSAQMVELYNQHREDLKKYKDYIKAY-LPEKYGETFKDATK
362

AKQ21048
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

WP_004636532
277
LLGMTDDVFLDVEMAAKNVYDAVEMSAIISTDTGNSKAVLSNQMINFYDEHKVDLAQLKOFFKTH-LPDKYYECFSDPSK
355

WP_002364836
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK
362

WP_016631044
235
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKEKRFIREN-CPDEYDNLFKNEQK
313

EMS75795
21
LLEKSGEEFRDVFLQAKKVYDAILLSDILSTKKONSKAKLSLGMIERYDSHKKDLEELKQFVKAN-LPEKTAIFFKDSSK
99

WP_002373311
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK
362

WP_002378009
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
362

WP_002407324
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
362

WP_002413717
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK
362

WP_010775580
286
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
364

WP_010818269
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK
362

WP_010824395
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
362

WP_016622645
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSYAKLSSSMIVRFTEHQEDLKKEKRFIREN-CPDEYDNLFKNEQK
362

WP_033624816
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
362

WP_033625576
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK
362

WP_033789179
284
ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK
362

WP_002310644
282
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
360

WP_002312694
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_002314015
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_002320716
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_002330729
282
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
360

WP_002335161
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_002345439
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_034867970
276
LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTKAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK
354

WP_047937432
283
LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV
361

WP_010720994
276
LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTQAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK
354

WP_010737004
276
LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTKAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK
354

WP_034700478
276
LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTQAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK
354

WP_007209003
281
LLAIIGDEYGDIFVAAONLYQAILLAGILTSTEK-TRAKLSASMIQRYEEHAKDLKLLKRFVKEH-IPDKYAEIFNDATK
358

WP_023519017
276
LLEKTSDDYAELFLKAKGVYDAILLSQILSKSDDETKAKLSANMKLRFEEHQRDLKOLKELVRRD-LPKKYDDFFKNRSK
354

WP_010770040
279
LLAIIGDEYAEIFSATKSVYDAVALSGILSVTDGDTKAKLSASMVERYEAHQKDLVOFKQFIRKE-LPEMYAPIFRDNSV
357

WP_048604708
275
LLGEIGDEYADVFEAAKNVYNAVELSGILTVTDNSTKAKLSASMIKRYEDHKTDLKLFKEFIRKN-LPEKYHEIFNDKNT
353

WP_010750235
276
LLRKSNEEMIDVFLQVKKVYDAILLSDILSTKMKDTKAKLSAGMIERYQNHKKDLEELKOFVRAH-LHEKVTVFFKDSSK
354

AII16583
317
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHODLTLLKALVROQ-LPEKYKEIFFDQSK
395

WP_029073316
290
KOPLLGD-CVEFIDLLHDIYSWVELQNILGSAHTS-EPSISAAMIQRYEDHKNDLKLLKDVIRKY-LPKKYFEVERDEKS
366

WP_031589969
290
KQPLLGD-CVEFIDLLHDIYSWVELQNILGSAHTS-EPSISAAMIQRYEDHKNDLKLLKDVIRKY-LPKKYFEVERDEKS
366

KDA45870
276
LLAEAGDQYLDIFVAAKKVYDAAILASILDVKDTQTKTVESQAMIERYEEHQKDLIELKRVFKKY-LPEKCHDFFSE-PK
353

WP_039099354
286
LESSLDDNAHQIIESLQELYSGVLLAGIVPENQSLS-----QAMITKYDDHQKHLKMLKAVREAL-APEDRORLKQAYDQ
359

AKP02966
279
LDSILDDDQFTVLDTANRIYSTITLNEIL-----NGESYFSMAKVNQYENHAIDLCKLRDMWHTT----KNEKAV-GLSR
348

WP_010991369
284
LLALIGDEYAELFVAAKNAYSAVVLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK
362

WP_033838504
284
LLALIGDEYAELFVAAKNAYSAVVLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK
362

EHN60060
287
LLALIGDEYAELFVAAKNAYSAVVLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK
365

EFR89594
53
LLALIGDEYAELFVAAKNAYSAVVLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK
131

WP_038409211
284
LLAKIGDEYAEIFVAAKSTYNAVVLSNIITVTDTETKAKLSASMIERFDKHAKDLKRLKAFFKMQ-LPEKFNEVENDIEK
362

EFR95520

--------------------------------------------------------------------------------

WP_003723650
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI
362

WP_003727705
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTATETNAKLSASMIERFDAHEKELGELKAFIKLH-LPKQYQEIFNNAEI
362

WP_003730785
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTATETNAKLSASMIERFDAHEKELGELKAFIKLH-LPKQYQEIFNNAEI
362

WP_003733029
284
LLAIIGDEFAEVFVAAKNAYNAVVLSNIITVIDSTTRAKLSASLIERFENHKEDLKKMKRFVRTY-LPEKYDEIFDDTEK
362

WP_003739838
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTDTETNAKLSASMIERFDAHEKDLSELKAFIKLH-LPKQYEEIFSNVAI
362

WP_014601172
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTATETNAKLSASMIERFDAHEKDLGELKAFIKLH-LPKQYQEIFNNAAI
362

WP_023548323
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI
362

WP_031665337
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVNDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI
362

WP_031669209
284
LLAIIGDEFAEVFVAAKNAYNAVVLSNIITVTDSTTRAKLSASLIERFENHKEDLKKMKRFVRTY-LPEKYDEIFDDTEK
362

WP_033920898
284
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI
362

AKI42028
287
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTATETNAKLSASMIERFDAHEKDLGELKAFIKLH-LPKQYQEIFNNAAI
365

AKI50529
287
LLAIIGDEYAELFVAAKNTYNAVVLSSIITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI
365

EFR83390

--------------------------------------------------------------------------------

WP_046323366
284
LLARVGDEYAEIFVAAKNAYNAVVLSSIITVSNTETKAKLSASMIERFDKHDKDLKRMKAFFKVR-LPENFNEVENDVEK
362

AKE81011
294
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
372

CUO82355
288
VENDLGE-YVEFIDSLHNIYSWVELQTIMGATHTD-NASISEAMVSRYNKIHEDLOLLKKCIKDN-VPKKYFDMFRNDSE
364

WP_033162887
289
LQSELGE-YIEFIEMLHNIYSWVELQAILGATHTD-NPSISAAMVERYEEHKKDLRVLKKVIREE-LPDKYNEVERKDNR
365

AGZ01981
311
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
389

AKA60242
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLILLKALVRQQ-LPEKYKEIFFDQSK
356

AKS40380
278
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK
356

4UN5_B
282
LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVROQ-LPEKYKEIFFDQSK
360

WP_010922251
357

embedded image

419

WP_039695303
358
--NGYAG YIEN G VKQDEFYKYLKNILSK-IkiDGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
422

WP_045635197
357
--DGYAG YIDG K TTQETFYKYIKNLLSK-F--EGTDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

5AXW_A
169
------G SINR - ---------------K------TSDYVk----------------------------EA
183

WP_009880683
41
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
103

WP_010922251
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_011054416
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPYQIHLGEL
419

WP_011284745
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_011285506
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_011527619
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_012560673
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_014407541
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTEDNGSIPHQIHLGEL
419

WP_020905136
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_023080005
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPYQIHLGEL
419

WP_023610282
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPYQIHLGEL
419

WP_030125963
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTEDNGSIPHOIHLGEL
419

WP_030126706
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTEDNGSIPYQIHLGEL
419

WP_031488318
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_032460140
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_032461047
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_032462016
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_032462936
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_032464890
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNRKDLLRKORTFDNGSIPHQIHLGEL
419

WP_033888930
182
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
244

WP_038431314
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_038432938
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPYQIHLGEL
419

WP_038434062
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKQRTFDNGSIPHQIHLGEL
419

BAQ51233
268
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
330

KGE60162

------- ---- - ----------------------------------------------------------

KGE60856

------- ---- - ----------------------------------------------------------

WP_002989955
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_003030002
357
--KGYAG YIEN G VKQDEFYKYLKGILLQ-I--NGSGDFL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_003065552
360
--NGYAG YIEN G VKQDEFYKYLKNTLSK-Ia--GSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
422

WP_001040076
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040078
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040080
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040081
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040083
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040085
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040087
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040088
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040089
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040090
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040091
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040092
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040094
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040095
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040096
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040097
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040098
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040099
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040100
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040104
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040105
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040106
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040107
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040108
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTEDNGSIPHQVHLTEL
420

WP_001040109
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_001040110
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_015058523
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017643650
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017647151
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017648376
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017649527
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017771611
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_017771984
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

CFQ25032
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

CFV16040
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

KLJ37842
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

KLJ72361
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

KLL20707
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

KLL42645
358
--DGYAG YIEG K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_047207273
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTEDNGSIPHQVHLTEL
420

WP_047209694
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_050198062
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_050201642
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_050204027
358
--DGYAG YIES K TNQGAFYKYLSKLLTK-Q--EGSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_050881965
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

WP_050886065
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

AHN30376
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSEYFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

EA078426
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EDSENFL--EKIKNEDFLRKORTFDNGSIPHQVHLTEL
420

CCW42055
358
--DGYAG YIEG K TNQEAFYKYLSKLLTK-Q--EGSEYLL--EKIKNEDFLRKORTEDNGSIPHQVHLTEL
420

WP_003041502
357
--KGYAG YIES G VKQDEFYKYLKGILLQ-I--NGSGDFL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_037593752
358
--KGYAG YIES G VEQDEFYKYLKGILLK-I--NGSGDFL--DKIDCEDFLRKORTFDNGSIPHQIHLQEM
420

WP_049516684
358
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--DGSDYFL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
420

GAD46167
357
--KGYAG YIES G VEQDEFYKYLKGILLK-I--NGSGDFL--DKIDCEDFLRKORTFDNGSIPHQIHLQEM
419

WP_018363470
358
--NGYAG YIEN G VKQDEFYKYLKGILTK-I--NGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_003043819
357
--NGYAG YVGI G ATQEEFYKFIKPILEK-M--DGAEELLa--KLNRDDLLRKORTFDNGSIPHQIHLKEL
429

WP_006269658
357
--KGYAS YIES G VKQDEFYKYLKGILLK-I--NGSGDFL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_048800889
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--DGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_012767106
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_014612333
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_015017095
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_015057649
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_048327215
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_049519324
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLa--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_012515931
357
--NGYAG YIEG Q VSQEEFYKYLKPILAR-L--DGSEPLL1--KIDREDFLRKORTFDNGSIPHQIHLEEL
419

WP_021320964
357
--NGYAG YIEG 2 VSQEEFYKYLKPILAR-L--DGSEPLL1--KIDREDFLRKORTEDNGSIPHQIHLEEL
419

WP_037581760
357
--NGYAG YIEG Q VSQEEFYKYLKPILAR-L--DGSEPLL1--KIDREDFLRKORTEDNGSIPHQIHLEEL
419

WP_004232481
357
--NGYAG YIEN G VKQDIFYKHLKSIISE-K--NGGQYFL--DKIEREDFLRKORTFDNGSIPYQIHLQEM
419

WP_009854540
358
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--DGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_012962174
358
--NGYAG YIEN G VKQDEFYKYLKTTLSK-I--DGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_039695303
358
--NGYAG YIEN G VKQDEFYKYLKNILSK-IkiDGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
422

WP_014334983
357
--NGYAG YIDN G VKQDEFYKYLKTILTK-I--DDSDYFL--DKIERDDFLRKORTFDNGSIPHQIHLQEM
419

WP_003099269
357
--NGYAG YIDG K TSQEEFYKYIKPILLK-L--DGTEKLIS--KLEREDFLRKORTEDNGSIPHQIHLNEL
419

AHY15608
357
--NGYAG YIDG K TSQEEFYKYIKPILLK-L--DGTEKLIS--KLEREDFLRKORTFDNGSIPHQIHLNEL
419

AHY17476
357
--NGYAG YIDG K TSQEEFYKYIKPILLK-L--DGTEKLIS--KLEREDFLRKORTFDNGSIPHQIHLNEL
419

ESR09100

------- ---- - ---------------------------------------------------------

AGM98575
357
--NGYAG YIDG K TSQEEFYKYIKPILLK-L--DGTEKLIs--KLEREDFLRKORTFDNGSIPHQIHLNEL
419

ALF27331
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_018372492
355
--PSYAA YVSG A VTEDDFYKFSKGLLID-V--EGAEYFL--EKIEREDFLRKORTFDNGAIPNQVHVKEL
432

WP_045618028
358
--DGYAG YIDG K TTQEAFYKYIKNLLSK-L--EGADYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_045635197
357
--DGYAG YIDG K TTQETFYKYIKNLLSK-F--EGTDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002263549
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002263887
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002264920
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--AGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002269043
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002269448
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002271977
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKQRTFDNGSIPHQIHLQEM
419

WP_002272766
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002273241
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002275430
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002276448
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002277050
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--AGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002277364
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002279025
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002279859
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002280230
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002281696
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002282247
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--TGSDYFL--DQIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002282906
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002283846
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002287255
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002288990
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002289641
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002290427
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002295753
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002296423
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002304487
357
--NGYAG YVGA D ATEEEFYKYVKGILNK-V--EGADVWL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
429

WP_002305844
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002307203
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002310390
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002352408
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_012997688
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTEDNGSIPHOIHLQEM
419

WP_014677909
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019312892
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019313659
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019314093
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019315370
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGNGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019803776
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_019805234
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_024783594
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_024784288
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--TGSDYFL--DQIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_024784666
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_024784894
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_024786433
357
--NGYAG YIEN G VKQDEFYKYLKNTLSK-I--AGSDYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_049473442
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHOIHLQEM
419

WP_049474547
357
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

EMC03581
350
--DGYAG YIDG K TNQEAFYKYLKGLLNK-I--EGSGYFL--DKIEREDFLRKORTFDNGSIPHOIHLQEM
412

WP_000428612
358
--DGYAG YIDG K TTQESFYKYIKNLLSK-F--EGADYFL--EKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_000428613
358
--DGYAG YIDG K TTQEAFYKYIKNLLSK-F--EGTDYFL--EKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_049523028
357
--DGYAG YIDG K TTQEGFYKYIKNLISK-I--EGAEYFL--EKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_003107102
326
--NGYAG YING K TSQEDFYKYIKPILSK-L--KGAESLIs--KLEREDFLRKQRTFDNGSIPHQIHLNEL
388

WP_054279288
359
--DGYAG YISG K TSQEAFYKYIKPILET-L--DGAEDFLt--KINREDFLRKORTFDNGSIPHQIHLGEL
421

WP_049531101
358
--EGYAG YIDS K TTQEAFYKYIKNLLSK-I--DGADYLL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_049538452
358
--DGYAG YVDG K TTQEAFYKYIKNLLSK-F--EGADYFL--EKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_049549711
358
--DGYAG YIDG K TTQEAFYKYIKNLLSK-F--EGTDYFL--EKIEREDFLRKORTFDNGSIPHQIHLQEM
420

WP_007896501
359
--NGYAG YIEG K VSQEDFYRYIKPILSR-L--KGGDEFLa--KIDRDDFLRKORTFDNGSIPHQIHLKEL
421

EFR44625
311
--NGYAG YIEG K VSQEDFYRYIKPILSR-L--KGGDEFLa--KIDRDDFLRKORTFDNGSIPHQIHLKEL
373

WP_002897477
357
--DGYAG YIDG K TTQEAFYKYIKNLLSK-F--EGADYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_002906454
357
--DGYAG FIDG K TTQEAFYKYIKNLLSK-L--EGADYFL--NKIEREDFLRKORTFDNGSIPHQIHLQEM
419

WP_009729476
358
--DGYAG YIDG K TTQETFYKYIKNLLSK-F--EGADYFL--DKIEREDFLRKORTFDNGSIPHQIHLQEM
420

CQR24647
358
--NGYAG YIDG K TNQEDFYKYLKNLLQK-V--DGGDYFI--EKIEREDFLRKORTFDNGSIPHQVHLDEM
420

WP_000066813
358
--DGYAG YIDG K TTQEAFYKYIKNLLSK-F--EGADYFL--DKIEREDFLKKORTFDNGSIPHQIHLQEM
420

WP_009754323
358
--DGYAG YIDG K TTQEAFYKYIKNLLSK-F--EGADYFL--DKIEREDFLRKORTEDNGSIPHQIHLQEM
420

WP_044674937
357
--DGYAG YIEG K TTQENFYRFIKKAIEK-I--EGSDYFI--DKIDREDFLRKORTFDNGSIPHOIHLQEM
419

WP_044676715
357
--DGYAG YIEG K TTQENFYRFIKKAIEK-I--EGSNYFI--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_044680361
357
--DGYAG YIEG K TTQENFYRFIKKAIEK-I--EGSNYFI--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_044681799
357
--DGYAG YIEG K TTQENFYRFIKKAIEK-I--EGSDYFI--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_049533112
357
--KGYAG YIEN G VKQDEFYKYLKGILLQ-I--NGSGDFL--DKIDREDFLRKORTFDNGSIPHQIHLQEM
419

WP_029090905
316
fyTDYIG YEES K SKEERLFKHIELLLAKENVITTVEHALleKNITFASLLPLORSSRNAVIPYQVHEKEL
403

WP_006506696
361
ksKGYYN YINR K APVDEFYKYVKKCIEK-VdtPEAKQILn--DIELENFLLKONSRINGSVPYQMQLDEM
429

AIT42264
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_034440723
363
--NGYAG YIDG K TSQEDFYKFVKAQLKG---eENGEYFL--EAIENENFLRKORSFYNGVIPYQIHLQEL
425

AKQ21048
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

WP_004636532
356
--NGYAG YIDG K TNQEDFYKYIEKVMKT-IksDKKDYFL--DKIDREVFLRKORSFYNSVIPHQIHLQEM
420

WP_002364836
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_016631044
314
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
378

EMS75795
100
--NGYAG YIDG K TTQEDFYKFLKKELNG-I--AGSERFM--EKVDQENFLLKORTTANGVIPHQVHLTEL
162

WP_002373311
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_002378009
363
--DGYAG YITH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_002407324
363
--DGYAG YITH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_002413717
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_010775580
365
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
429

WP_010818269
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_010824395
363
--DGYAG YITH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_016622645
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_033624816
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_033625576
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_033789179
363
--DGYAG YIAH A VSQLKFYQYVKKIIQD-I--AGAEYFL--EKIAQENFLRKORTFDNGVIPHQIHLAEL
427

WP_002310644
361
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
423

WP_002312694
362
--NGYAG YIEG H ATQEAFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLSEL
424

WP_002314015
362
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
424

WP_002320716
362
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
424

WP_002330729
361
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
423

WP_002335161
362
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKQRTFDNGVIPHQIHLTEL
424

WP_002345439
362
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
424

WP_034867970
355
--NGYAG YIKG K TTQEEFYKFVKKELSG-V--VGSEPFL--EKIDQETFLLKORTYTNGVIPHQVHLIEL
417

WP_047937432
362
--NGYAG YIEG H ATQEDFYKFVKKELTG-I--RGSEVFL--TKIEQENFLRKORTFDNGVIPHQIHLTEL
424

WP_010720994
355
--NGYAG YIKG K TTQEEFYKFVKKELSG-V--VGSEPFL--EKIDQETFLLKORTYTNGVIPHQVHLIEL
417

WP_010737004
355
--NGYAG YIKG K TTQEEFYKFVKKELSG-V--VGSEPFL--EKIDQETFLLKORTYTNGVIPHQVHLIEL
417

WP_034700478
355
--NGYAG YIKG K TTQEEFYKFVKKELSG-V--VGSEPFL--EKIDQETFLLKORTYTNGVIPHQVHLIEL
417

WP_007209003
359
--NGYAG YIDG K TKEEEFYKYLKTTLVQ---kSGYQYFI--EKIEQENFLRKORIYDNGVIPHQVHAEEL
421

WP_023519017
355
--NGYAG YVKG K ATQEDFYKFLRTELAG-L--EESQSIM--EKIDLEIYLLKORTFANGVIPHQIHLVEM
417

WP_010770040
358
--SGYAG YVEN S VTQAEFYKYIKKAIEK-V--PGAEYFL--EKIEQETFLDKORTENNGVIPHQIHLEEL
422

WP_048604708
354
--DGYAG YIDN S TSQEKFYKYITNLIEK-I--DGAEYFL--KKIENEDFLRKORTFDNGIIPHQIHLEEL
418

WP_010750235
355
--DGYAG YIDG K TTQADFYKFLKKELTG-V--PGSEPML--AKIDQENFLLKORTPINGVIPHQVHLTEF
417

AII16583
396
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTEDNGSIPHQIHLGEL
458

WP_029073316
367
kkNNYCN YINH K TPVDEFYKYIKKLIEK-IddPDVKTILn--KIELESFMLKONSRINGAVPYQMQLDEL
435

WP_031589969
367
kkNNYCN YINH K TPVDEFYKYIKKLIEK-IddPDVKTILn--KIELESFMLKONSRINGAVPYQMQLDEL
435

KDA45870
354
-iSGYAG YIDG K VSEEDFYKYTKKTLKG-I--PETEEILq--KIDANNYLRKORTFDNGAIPHQVHLKEL
417

WP_039099354
360
------- YVDG K -SKEDFYGDITKALKNnPdhPIVSEIKk--LIELDQFMPKORTKDNGAIPHQLHQQEL
425

AKP02966
349
--QAYDD YINK K ---KELYTSLKKFLKVaLp-TNLAKEAe-EKISKGTYLVKPRNSENGVVPYQLNKIEM
415

WP_010991369
363
--HGYAG YIDG - TKQADFYKYMKMTLEN-I--EGADYFI--AKIEKENFLRKORTFDNGAIPHOLHLEEL
425

WP_033838504
363
--HGYAG YIDG - TKQADFYKYMKMTLEN-I--EGADYFI--AKIEKENFLRKORTFDNGAIPHOLHLEEL
425

EHN60060
366
--HGYAG YIDG - TKQADFYKYMKMTLEN-I--EGADYFI--AKIEKENFLRKORTFDNGAIPHOLHLEEL
428

EFR89594
132
--HGYAG YIDG - TKQADFYKYMKTTLEN-I--EGADYFI--AKIEKENFLRKORTFDNGAIPHOLHLEEL
194

WP_038409211
363
--DGYAG YIDG - TTQEKFYKYMKKMLAN-I--DGADYFI--DQIEEENFLRKQRTFDNGTIPHQLHLEEL
425

EFR95520
1
------- ---- - ---------MKKMLAN-I--DGADYFI--DQIEEENFLRKORTFDNGTIPHQLHLEEL
44

WP_003723650
363
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGSDYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
425

WP_003727705
363
--DGYAG YIDG - TKQVDFYKYLKTTLEN-V--EGADYFI--TKIEEENFLRKORTFDNGVIPHQLHLEEL
425

WP_003730785
363
--DGYAG YIDG - TKQVDFYKYLKTTLEN-V--EGADYFI--TKIEEENFLRKORTFDNGVIPHQLHLEEL
425

WP_003733029
363
--HGYAG YISG - TKQADFYKYMKATLEK-I--EGADYFI--AKIEEENFLRKORTFDNGVIPHQLHLEEL
425

WP_003739838
363
--DGYAG YIDG - TKQVDFYKYLKTLLEN-I--EGADYFI--AKIEEENFLRKORTEDNGAIPHOLHLEEL
425

WP_014601172
363
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGADYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
425

WP_023548323
363
--DGYAG YIDG - TKQVDFYKYLKTTLEN-V--EGADYFI--TKIEEENFLRKORTFDNGVIPHQLHLEEL
425

WP_031665337
363
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGSDYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
425

WP_031669209
363
--HGYAG YISG - TKQADFYKYMKATLEK-I--EGADYFI--AKIEEENFLRKORTFDNGVIPHOLHLEEL
425

WP_033920898
363
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGADYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
425

AKI42028
366
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGADYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
428

AKI50529
366
--DGYAG YIDG - TKQVDFYKYLKTILEN-I--EGADYFI--AKIEEENFLRKORTFDNGAIPHOLHLEEL
428

EFR83390

------- ---- - ----------------------------------------------------------

WP_046323366
363
--DGYAG YIEG - TKQEAFYKYMKKMLEH-V--EGADYFI--NQIEEENFLRKORTEDNGAIPHOLHLEEL
425

AKE81011
373
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
435

CUO82355
365
kvKGYYN YINR K APVDEFYKFVKKCIEK-VdtPEAKQILh--DIELENFLLKONSRINGSVPYQMQLDEM
433

WP_033162887
366
k1HNYLG YIKY D TPVEEFYKYIKGLLAK-VdtDEAREILe--RIDLEKFMLKONSRINGSIPYQMQKDEM
434

AGZ01981
390
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
452

AKA60242
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

AKS40380
357
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
419

4UN5_B
361
--NGYAG YIDG G ASQEEFYKFIKPILEK-M--DGTEELLv--KLNREDLLRKORTFDNGSIPHQIHLGEL
423

WP_010922251
420

embedded image

WP_039695303
423
HAILRRQGDYYPFLKE--KQD RIEKILTFRIPYYVGPL VRKD--SRFAWAEY---RSDEKITPWNEDKVIDKEK
489

WP_045635197
420
NAILRRQGEYYPFLKD--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDEAIRPWNFEEIVDKAS
486

5AXW_A
184
KQLLKVOKAYHOLDQSfi--D TYIDLLETRRTYYEGPG ---Eg-SPFGWKDI----------------------
229

WP_009880683
104
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
170

WP_010922251
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_011054416
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_011284745
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_011285506
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_011527619
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_012560673
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_014407541
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_020905136
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_023080005
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_023610282
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_030125963
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_030126706
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_031488318
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_032460140
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_032461047
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_032462016
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_032462936
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_032464890
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_033888930
245
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
311

WP_038431314
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_038432938
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_038434062
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

BAQ51233
331
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
397

KGE60162

--------------------- ----------------- ------------------------------------

KGE60856

--------------------- ----------------- ------------------------------------

WP_002989955
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_003030002
420
HAILRRQEEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_003065552
423
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARKD--SRFSWAEY---HSDEKITPWNEDKVIDKEK
489

WP_001040076
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040078
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040080
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040081
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040083
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040085
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040087
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040088
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040089
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040090
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040091
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040092
421
KAIIRRQSEYYPFLKE--NQD KIEKILTFRIPYYVGPL ARGN--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040094
421
RAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040095
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040096
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040097
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040098
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040099
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040100
421
RAIIRRQSEYYPLLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040104
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040105
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_001040106
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_001040107
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_001040108
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_001040109
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_001040110
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_015058523
421
KAIIRROSEYYPFLKE--NQD KIEKILTFRIPYYVGPL ARGN--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_017643650
421
RAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_017647151
421
KAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_017648376
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_017649527
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_017771611
421
KAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_017771984
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

CFQ25032
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

CFV16040
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

KLJ37842
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

KLJ72361
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

KLL20707
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

KLL42645
421
KAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_047207273
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KIDDSIRPWNFEDLVDKEK
487

WP_047209694
421
RAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KIDDSIRPWNFEDLVDKEK
487

WP_050198062
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KIDDSIRPWNFEDLVDKEK
487

WP_050201642
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_050204027
421
KAIIRRQSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KIDDSIRPWNFEELVDKEA
487

WP_050881965
421
KAIIRROSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

WP_050886065
421
KDIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

AHN30376
421
KAIIRRQSEYYPFLKE--NQD KIEKILTFRIPYYVGPL ARGN--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

EAO78426
421
KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK
487

CCW42055
421
RAIIRROSEYYPFLKE--NLD RIEKILTFRIPYYVGPL AREK--SDFAWMTR---KTDDSIRPWNFEELVDKEA
487

WP_003041502
420
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_037593752
421
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
487

WP_049516684
421
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
487

GAD46167
420
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_018363470
421
HAILRRQGDYYPFLKE--NQE EIEKILTFRIPYYVGPL ARKD--SRFAWAEY---RSDEKITPWNEDKVIDKEK
487

WP_003043819
430
HAILRRQEEFYPFLKE--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWLTR---KSEEAITPWNFEEVVDKGA
496

WP_006269658
420
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_048800889
420
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL VRKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_012767106
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_014612333
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_015017095
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_015057649
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_048327215
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_049519324
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_012515931
420
HAILRRQEVFYPFLKD--NRK KIESLLTFRIPYYVGPL ARG-h-SRFAWVKR---KFDGAIRPWNFEEIVDEEA
486

WP_021320964
420
HAILRRQEVFYPFLKD--NRK KIESLLTFRIPYYVGPL ARG-h-SRFAWVKR---KFDGAIRPWNFEEIVDEEA
486

WP_037581760
420
HAILRRQEVFYPFLKD--NRK KIESLLTFRIPYYVGPL ARG-h-SRFAWVKR---KFDGAIRPWNFEEIVDEEA
486

WP_004232481
420
RTILRRQGEYYPFLKE--NQA KIEKILTFRIPYYVGPL ARKN--SRFAWAKY---HSDEPITPWNFDEVVDKEK
486

WP_009854540
421
HAILRRQGDYYPFLKE--KQD RIEKILTFRIPYYVGPL VRKD--SRFAWAEY---RSDEKITPWNFDKVIDKEK
487

WP_012962174
421
HAILRRQGEHYAFLKE--NQA KIEKILTFRIPYYVGPL ARKN--SRFAWAEY---HSDEKITPWNFDEIIDKEK
487

WP_039695303
423
HAILRRQGDYYPFLKE--KOD RIEKILTFRIPYYVGPL VRKD--SRFAWAEY---RSDEKITPWNEDKVIDKEK
489

WP_014334983
420
HSILRRQGDYYPFLKE--NQA KIEKILTFRIPYYVGPL ARKD--SRFAWANY---HSDEPITPWNFDEVVDKEK
486

WP_003099269
420
KAIIRRQEKFYPFLKE--NQK KIEKLFTFKIPYYVGPL ANG-q-SSFAWLKR---QSNESITPWNFEEVVDQEA
486

AHY15608
420
KAIIRRQEKFYPFLKE--NQK KIEKLFTFKIPYYVGPL ANG-q-SSFAWLKR---QSNESITPWNFEEVVDQEA
486

AHY17476
420
KAIIRRQEKFYPFLKE--NQK KIEKLFTFKIPYYVGPL ANG-q-SSFAWLKR---QSNESITPWNFEEVVDQEA
486

ESR09100

--------------------- ----------------- ------------------------------------

AGM98575
420
KAIIRRQEKFYPFLKE--NQK KIEKLFTFKIPYYVGPL ANG-q-SSFAWLKR---QSNESITPWNFEEVVDQEA
486

ALF27331
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYIGPL ARGK--SDFSWLSR---KSADKITPWNFDEIVDKES
486

WP_018372492
433
QAIILNQSKYYPFLAE--NKE KIEKILTFRIPYYVGPL ARGN--SSFAWLQR---KSDEAIRPWNFEQVVDMET
499

WP_045618028
421
NAIIRRQGEHYPFLQE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAR
487

WP_045635197
420
NAILRRQGEYYPFLKD--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDEAIRPWNFEEIVDKAS
486

WP_002263549
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002263887
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002264920
420
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002269043
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002269448
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002271977
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002272766
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002273241
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002275430
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002276448
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002277050
420
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARKN--SRFAWAEY---HSDEAVMPWNEDQVIDKES
486

WP_002277364
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002279025
420
RAIIRRQSEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002279859
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002280230
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002281696
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002282247
420
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARKN--SRFAWAEY---HSDEAVTPWNFDQVIDKES
486

WP_002282906
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002283846
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002287255
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002288990
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002289641
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ASGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002290427
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002295753
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002296423
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002304487
430
HAILRRQGEHYPFLKE--NQD KIEKILTFRIPYYVGPL VRKG--SRFAWAEY---KADEKITPWNEDDILDKEK
496

WP_002305844
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002307203
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002310390
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_002352408
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_012997688
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_014677909
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019312892
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019313659
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019314093
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019315370
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019803776
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_019805234
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_024783594
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_024784288
420
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARKN--SRFAWAEY---HSDEAVTPWNEDQVIDKES
486

WP_024784666
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_024784894
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ASGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_024786433
420
HAILRRQGDYYPFLKE--NQD RIEKILTFRIPYYVGPL ARKN--SRFAWAEY---HSDEAVTPWNFDQVIDKES
486

WP_049473442
420
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

WP_049474547
420
RAIIRRQAEFYPFLAD--NQD RIEKLLTFRIPYYVGPL ASGK--SDFAWLSR---KSADKITPWNFDEIVDKES
486

EMC03581
413
RAIIRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR---KSADKITPWNFDEIVDKES
479

WP_000428612
421
NAILRRQGEHYPFLKE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

WP_000428613
421
NAILRRQGEHYPFLKD--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDEAIRPWNFEEIVDKAS
487

WP_049523028
420
NAILRHQGEYYPFLKE--NKD KIEQILTFRIPYYVGPL ARGN--SDFAWLSR---NSDEAIRPWNFEEMVDKSS
486

WP_003107102
389
KSIIRRQEKYYPFLKD--KQV RIEKIFTFRIPYFVGPL ANG-n-SSFAWVKR---RSNESITPWNFEEVVEQEA
455

WP_054279288
422
QAILERQQAYYPFLKD--NQE KIEKILTFRIPYYIGPL ARG-n-SRFAWLTR---TSDQKITPWNFDEMVDQEA
488

WP_049531101
421
NAILRRQGEHYPFLKE--NRE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

WP_049538452
421
NAILRRQGEHYPFLKE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

WP_049549711
421
NAILRRQGEHYPFLKE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

WP_007896501
422
HAILRRQEKYYPFLAE--QKE KIEQLLCFRIPYYVGPL AKGGn-SSFAWLKR---RSDEPITPWNFKDVVDEEA
489

EFR44625
374
HAILRRQEKYYPFLAE--QKE KIEQLLCFRIPYYVGPL AKGGn-SSFAWLKR---RSDEPITPWNFKDVVDEEA
441

WP_002897477
420
NAILRRQGEHYPFLKE--NRE KIEKILTFRIPYYVGPL ARDN--RDFSWLTR---NSDEPIRPWNFEEVVDKAR
486

WP_002906454
420
NAILRRQGEHYLFLKE--NRE KIEKILAFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEVVDKAS
486

WP_009729476
421
NAILRRQGEHYPFLKE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

CQR24647
421
KAILRRQGEFYPFLKE--NAE KIQQILTFKIPYYVGPL ARGN--SRFAWASY---NSNEKMTPWNEDNVIDKTS
487

WP_000066813
421
NAIIRRQGEHYPFLQE--NKE KIEKILTFRIPYYVGPL ARGN--GDFAWLTR---NSDQAIRPWNFEEIVDQAS
487

WP_009754323
421
NAILRRQGEHYPLLKE--NKE KIEKILTFRIPYYVGPL ARGN--RDFAWLTR---NSDQAIRPWNFEEIVDKAS
487

WP_044674937
420
HAIIRRQAEFYPFLVE--NQD KIEKILTFRIPYYVGPL ARGK--SEFAWLNR---KSDEKIRPWNFDEMVDKET
486

WP_044676715
420
HAIIRRQAEFYPFLVE--NQD KIEKILTFRIPYYVGPL ARGK--SEFAWLNR---KSDEKIRPWNFDEMVDKET
486

WP_044680361
420
HAIIRRQAEFYPFLVE--NQD KIEKILTFRIPYYVGPL ARGK--SEFAWLNR---KSDEKIRPWNFDEMVDKET
486

WP_044681799
420
HAIIRRQAEFYPFLVE--NQD KIEKILTFRIPYYVGPL ARGK--SEFAWLNR---KSDEKIRPWNFDEMVDKET
486

WP_049533112
420
HAILRRQEEHYPFLKE--NQD KIEKILTFRIPYYVGPL ARKG--SRFAWAEY---KADEKITPWNEDDILDKEK
486

WP_029090905
404
VAILENQATYYPFLLE--QKD NIHKLLTFRIPYYVGPL ADQKd-SEFAWMVR---KQAGKITPFNFEEMVDIDA
471

WP_006506696
430
IKIIDNQAEYYPILKE--KRE QLLSILTFRIPYYFGPL ETSEh----AWIKRlegKENQRILPWNYQDIVDVDA
498

AIT42264
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_034440723
426
TAVLDQQEKHYSFLKE--NRD KIISLLTFRIPYYVGPL AKGE--SRFAWLER--sNSEEKIKPWNEDKIVDIDK
493

AKQ21048
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

WP_004636532
421
QAILDRQSQYYPFLAE--NRD KIESLVTFRIPYYVGPL TVSDq-SEFAWMER---QSDEPIRPWNEDEIVNKER
488

WP_002364836
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_016631044
379
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
446

EMS75795
163
KAIIERQKPYYPSLEE--ARD KMIRLLTFRIPYYVGPL AQGEetSSFAWLER---KTPEKVTPWNATEVIDYSA
231

WP_002373311
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_002378009
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-NTFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_002407324
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_002413717
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_010775580
430
QAIIHRQAAYYPFLKE--NOK KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDO
497

WP_010818269
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_010824395
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_016622645
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_033624816
428
QAIIHRQAAYYPFLKE--NQK KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_033625576
428
QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QNEKPIRPWNLQETVDLDO
495

WP_033789179
428
QAIIHRQAAYYPFLKE--NQK KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR---QSEEPIRPWNLQETVDLDQ
495

WP_002310644
424
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
492

WP_002312694
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_002314015
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_002320716
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_002330729
424
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
492

WP_002335161
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_002345439
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_034867970
418
KAIIDQQKQHYPFLEE--AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER---KTAEKINPWNFSEVVDIEK
486

WP_047937432
425
RAIIANQKKHYPFLKE--EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR---KSEEKIKPWNLPEIVDMEG
493

WP_010720994
418
KAIIDQQKQHYPFLEE--AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER---KTAEKINPWNFSEVVDIEK
486

WP_010737004
418
KAIIDQQKQHYPFLEE--AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER---KTAEKINPWNFSEVVDIEK
486

WP_034700478
418
KAIIDQQKQHYPFLEE--AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER---KTAEKINPWNFSEVVDIEK
486

WP_007209003
422
RAILRKQEKYYSFLKE--NHE KIEQIFKVRIPYYVGPL AKHNeqSRFAWNIR---KSDEPIRPWNMNDVVDENA
490

WP_023519017
418
REIMDRQKRFYPFLKG--AQG KIEKLLTFRIPYYVGPL AQEGq-SPFAWIKR---KSPSQITPWNFAEVVDKEN
485

WP_010770040
423
EAIIQKQATYYPFLAD--NKE EMKQLVTFRIPYYVGPL ADGN--SPFAWLER---ISSEPIRPGNLAEVVDIKK
489

WP_048604708
419
KAILHHQAMYYPFLQE--KFS NFVDLLTFRIPYYVGPL ANGN--SRFSWLSR---KSDEPIRPWNLAEVVDLSK
485

WP_010750235
418
KAIIDQQKQYYPFLEK--SKE KMIQLLTFRIPYYVGPL AQDKetSSFAWLER---KTTEKIKPWNAKDVIDYGA
486

AII16583
459
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
525

WP_029073316
436
NKILENQSVYYSDLKD--NED KIRSILTFRIPYYFGPL ITKDr--QFDWIIKkegKENERILPWNANEIVDVDK
506

WP_031589969
436
NKILENQSVYYSDLKD--NED KIRSILTFRIPYYFGPL ITKDr--QFDWIIKkegKENERILPWNANEIVDVDK
506

KDA45870
418
VAIVENQGKYYPFLRE--NKD KFEKILNFRIPYYVGPL ARGN--SKFAWLTR--a-GEGKITPYNFDEMIDKET
484

WP_039099354
426
DRIIENQQQYYPWLAE-1NPN KLDELVAFRVPYYVGPL QQQSsdAKFAWMIR---KAEGQITPWNEDDKVDRQA
509

AKP02966
416
EKIIDNQSQYYPFLKE--NKE KLLSILSFRIPYYVGPL -QSSekNPFAWMER---KSNGHARPWNFDEIVDREK
483

WP_010991369
426
EAILHQQAKYYPFLKE--NYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_033838504
426
EAILHQQAKYYPFLKE--NYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

EHN60060
429
EAILHQQAKYYPFLKE--NYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
495

EFR89594
195
EAILHQQAKYYPFLKE--NYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
261

WP_038409211
426
EAILHQQAKYYPFLRK--DYE KIRSLVTFRIPYFIGPL ANGQ--SDFAWLTR---KADGEIRPWNIEEKVDFGK
492

EFR95520
45
EAILHQQAKYYPFLRK--DYE KIRSLVTFRIPYFIGPL ANGQ--SDFAWLTR---KADGEIRPWNIEEKVDFGK
111

WP_003723650
426
EAIIHQQAKYYPFLKE--DYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_003727705
426
EAILHQQAKYYPFLRE--GYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KDDGEIRPWNIEEKVDFGK
492

WP_003730785
426
EAILHQQAKYYPFLRE--GYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KDDGEIRPWNIEEKVDFGK
492

WP_003733029
426
EAILHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_003739838
426
EAILHQQAKYYPFLKE--AYD KIKSLVTFRIPYFVGPL ANGQ--SDFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_014601172
426
EAIIHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_023548323
426
EAILHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_031665337
426
EAIIHQQAKYYTFLKE--DYD KIKSLVTFRIPYFVGPL ANGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_031669209
426
EAILHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
492

WP_033920898
426
EAIIHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDEGK
492

AKI42028
429
EAIIHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
495

AKI50529
429
EAIIHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ--SEFAWLTR---KADGEIRPWNIEEKVDFGK
495

EFR83390

--------------------- ----------------- ------------------------------------

WP_046323366
426
EAILHQQAKYYPFLKV--DYE KIKSLVTFRIPYFVGPL ANGQ--SEFSWLTR---KADGEIRPWNIEEKVDFGK
492

AKE81011
436
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
502

CUO82355
434
IKIIDNQAKYYPVLKE--KRE QLLSILTFRIPYYFGPL ETSEh----AWIKRlegKENQRILPWNYQDTVDVDA
502

WP_033162887
435
IQIIDNQSVYYPQLKE--NRD KLISILEFRIPYYFGPL AHSE----FAWIKKfedKQKERILPWNYDQIVDIDA
503

AGZ01981
453
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
519

AKA60242
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

AKS40380
420
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
486

4UN5_B
424
HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR---KSEETITPWNFEEVVDKGA
490

WP_010922251
487

embedded image

561

WP_039695303
490
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN--EQGKES-FFDSNMKQEIFDHVFK--ENR-KVTK
563

WP_045635197
487
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNOLFK--ENR-KVTE
561

5AXW_A
230
--KEWYEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITR--DENEKLeYYE---KFQIIENVFK--QKK-KPTL
299

WP_009880683
171
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
245

WP_010922251
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_011054416
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_011284745
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_011285506
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_011527619
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_012560673
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_014407541
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_020905136
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_023080005
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_023610282
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_030125963
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_030126706
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_031488318
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_032460140
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_032461047
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_032462016
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_032462936
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_032464890
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_033888930
312
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
386

WP_038431314
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_038432938
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_038434062
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

BAQ51233
398
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
472

KGE60162

--------------------------------------------------------------------------------

KGE60856

--------------------------------------------------------------------------------

WP_002989955
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_003030002
487
SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN--EQGEAK-FFDANMKQEIFDHVFK--ENR-KVTK
560

WP_003065552
490
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN--EQGKDS-FFDSNMKQEIFDHVFK--ENR-KVTK
563

WP_001040076
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040078
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040080
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040081
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040083
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040085
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040087
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040088
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040089
488
SAEAFHIRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040090
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040091
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040092
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNVKQEIFDGVFK--EHR-KVSK
561

WP_001040094
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040095
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040096
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040097
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040098
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040099
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040100
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_001040104
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040105
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040106
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040107
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040108
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040109
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_001040110
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_015058523
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNVKQEIFDGVFK--EHR-KVSK
561

WP_017643650
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_017647151
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_017648376
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_017649527
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_017771611
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_017771984
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

CFQ25032
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

CFV16040
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

KLJ37842
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

KLJ72361
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

KLL20707
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

KLL42645
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_047207273
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_047209694
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA--EGFKDFqFLNRKQKETIFNSLFK--EKR-KVTE
562

WP_050198062
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_050201642
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_050204027
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_050881965
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

WP_050886065
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

AHN30376
488
SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNVKQEIFDGVFK--EHR-KVSK
561

EAO78426
488
SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-KVSK
561

CCW42055
488
SAEAFIHCMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EYR-KVSK
561

WP_003041502
487
SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN--EQGEAK-FFDANMKQEIFDHVFK--ENR-KVTK
560

WP_037593752
488
SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN--EQGEAK-FFDTNMKQEIFDHVFK--ENR-KVTK
561

WP_049516684
488
SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN--EQGEAK-FFDTNMKQEIFDHVFK--ENR-KVTK
561

GAD46167
487
SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN--EQGEAK-FFDTNMKQEIFDHVFK--ENR-KVTK
560

WP_018363470
488
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETFAVYNELTKVKYVN--EQGKDS-FFDSNMKQEIFDHVFK--ENR-KVTK
561

WP_003043819
497
SAQSFIERMTNFDEQLPNKKVLPKHSLLYEYFTVYNELTKVKYVT--ERMRKPeFLSGEQKKAIVDLLFK--TNR-KVTV
571

WP_006269658
487
SAEKFITRMTLNDLYLPEEKVLPKHSPLYEAFTVYNELTKVKYVN--EQGEAK-FFDTNMKQEIFDHVFK--ENR-KVTK
560

WP_048800889
487
SAEKFITRMTLNDLYLPEEKVLPKHSLLYEIFTVYNELTKVKYVN--EQGEAK-FFDANMKQEIFDHVFK--ENP-KVTK
560

WP_012767106
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGKQKEAIVDLLFK--TNR-KVTV
561

WP_014612333
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGKQKEAIVDLLFK--TNR-KVTV
561

WP_015017095
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGKQKEAIVDLLFK--TNR-KVTV
561

WP_015057649
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGKQKEAIVDLLFK--TNR-KVTV
561

WP_048327215
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPeFLSGKQKEAIVDLLFK--TNR-KVTV
561

WP_049519324
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_012515931
487
SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT--EGMTRPqFLSADQKQAIVDLLFK--TNR-KVTV
561

WP_021320964
487
SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT--EGMTRPqFLSADQKQAIVDLLFK--TNR-KVTV
561

WP_037581760
487
SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT--EGMTRPqFLSADQKQAIVDLLFK--TNR-KVTV
561

WP_004232481
487
SAEKFITRMTLNDLYLPEEKVLPKHSYVYETFAVYNELTKIKYVN--EQGKSF-FFDANMKQEIFDHVFK--ENR-KVTK
560

WP_009854540
488
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN--EQGKES-FFDSNMKQEIFDHVFK--ENR-KVTK
561

WP_012962174
488
SAEKFITRMTLNDLYLPEEKVLPKHSLVYETYTVYNELTKVKYVN--EQGKSN-FFDANMKQEIFEHVFK--ENR-KVTK
561

WP_039695303
490
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN--EQGKES-FFDSNMKQEIFDHVFK--NR-KVTK
563

WP_014334983
487
SAEKFITRMTLNDLYLPEEKVLPKHSHVYETFTVYNELTKIKYVN--EQGESF-FFDANMKQEIFDHVFK--ENR-KVTK
560

WP_003099269
487
SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT--EGMKRPVFLSSEDKEEIVNLLFK--KER-KVTV
561

AHY15608
487
SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT--EGMKRPVFLSSEDKEEIVNLLFK--KER-KVTV
561

AHY17476
487
SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT--EGMKRPVFLSSEDKEEIVNLLFK--KER-KVTV
561

ESR09100

--------------------------------------------------------------------------------

AGM98575
487
SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT--EGMKRPVFLSSEDKEEIVNLLFK--KER-KVTV
561

ALF27331
487
SAEAFINRMTNYDLYLPNQKVLPRHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_018372492
500
SASRFIERMTLHDLYLPDEKVLPRHSLIYEKYTVFNELTKVRFTP--EGGKEV-YFSKIDKENIFDSLFK--RYR-KVTK
573

WP_045618028
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKQQIVTQLFK--EKR-KVTE
562

WP_045635197
487
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNQLFK--ENR-KVTE
561

WP_002263549
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002263887
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELIKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002264920
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002269043
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002269448
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002271977
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002272766
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002273241
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002275430
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002276448
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002277050
487
SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT--EIGEAK-FFDANLKQEIFDGLFK--HER-KVTK
560

WP_002277364
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002279025
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGETA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002279859
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002280230
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002281696
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002282247
487
SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT--EIGEAK-FFDANLKQEIFDGLFK--HER-KVTK
560

WP_002282906
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002283846
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002287255
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002288990
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002289641
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002290427
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002295753
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002296423
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002304487
497
SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN--EQGEAK-FFDANMKQEIFDHVFK--ENR-KVTK
570

WP_002305844
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002307203
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002310390
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_002352408
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_012997688
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_014677909
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019312892
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019313659
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019314093
487
SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019315370
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019803776
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_019805234
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_024783594
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_024784288
487
SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT--EIGEAK-FFDANLKQEIFDGLFK--HER-KVTK
560

WP_024784666
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_024784894
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_024786433
487
SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT--EIGEAK-FFDANLKQEIFDGLFK--HER-KVTK
560

WP_049473442
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_049474547
487
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
560

EMC03581
480
SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA-FFDANMKQEIFDGVFK--VYR-KVTK
553

WP_000428612
488
SAESFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSROKKDIFYTLFKaeDKR-KVTE
564

WP_000428613
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVTQLFK--EKR-KVTE
562

WP_049523028
487
SAEDFIHRMTNYDLYLPEEKVLPKHSLLYETFTVYNELTKVKYIA--EGMKDYqFLDSGOKKQIVNOLFK--EKR-KVTE
561

WP_003107102
456
SAKVFIERMTNFDTYLPEEKVLPKHSLLYEMFTVYNELTKVKYQA--EGMRKPeFLSSEEKIEIVSNLFK--TER-KVTV
530

WP_054279288
489
SAQAFIERMTNFDEYLPQEKVLPKHSLTYEYFTVYNELTKVKYVT--EGMTKPeFLSAGQKEQIVELLFK--KYR-KVTV
563

WP_049531101
488
SAEAFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKKIINQLFK--EKR-KVTE
562

WP_049538452
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNOLFK--EKR-KVTE
562

WP_049549711
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNQLFK--EKR-KVTE
562

WP_007896501
490
SAQAFIEGMTNYDTYLPEEKVLPKHSPLYEMFTVYNELTKVKYIA--ENMTKPIYLSAEQKEAIIDHLFK--QTR-KVTV
564

EFR44625
442
SAQAFIEGMTNYDTYLPEEKVLPKHSPLYEMFTVYNELTKVKYIA--ENMTKP1YLSAEQKEAIIDHLFK--QTR-KVTV
516

WP_002897477
487
SAEDFIHRMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNQLFK--EKR-KVTE
561

WP_002906454
487
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVNQLFK--DKR-KVTE
561

WP_009729476
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFLDSGQKKQIVTQLFK--EKR-KVTE
562

COR24647
488
SAQAFIERMINNDLYLPDQKVLPKHSLLYQKFAVYNELTKIKYVT--ETGEAR-LFDVELKKEIFDGLFK--KER-KVTK
561

WP_000066813
488
SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLTRYqFLDKKQKKDIFDTFFKaeNKR-KVTE
564

WP_009754323
488
SAESFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA--EGLRDYqFFDSGQKKQIVNOLFK--EKR-KVTE
562

WP_044674937
487
SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVKFIA--EGMRDYqFLDSGQKKDIVKTLFK--TKR-KVTA
561

WP_044676715
487
SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVRYVT--EQGKSF-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_044680361
487
SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVRYVT--EQGKSF-FFDANMKQEIFDGVFK--VYR-KVTK
560

WP_044681799
487
SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVKFIA--EGMRDYqFLDSGQKKDIVKTLFK--TKR-KVTA
561

WP_049533112
487
SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN--EQGEAK-FFDANMKQEIFDHVFK--ENR-KVTK
560

WP_029090905
472
SSEAFIKRMINKCTYLIHEDVIPKHSFSYAKFEVLNELNKIRLDG------KP--IDIPLKKRIFEGLFL---EKtKVTQ
540

WP_006506696
499
TAEGFIKRMRSYCTYFPDEEVLPKNSLIVSKYEVYNELNKIRVDD--------kLLEVDVKNDIYNELFM--KNK-TVTE
567

AIT42264
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_034440723
494
SAELFIENLTSRDTYLPDEPVLPKRSLIYQKFTIFNELTKISYID--ERGILQ-NFSSREKIAIFNDLFK---NKsKVTK
567

AKQ21048
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

WP_004636532
489
SAEKFIERMTNMDTYLLEEKVLPKRSLLYQTFEVYNELTKVRYTN--EQGKTE-KLNRQQKAEIIETLFK-qKNR--VRE
562

WP_002364836
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVENELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_016631044
447
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
520

EMS75795
232
SAMKFIQRMINYDTYLPTEKVLPKHSILYQKYTIFNELTKVAYKD--ERGIKH-QFSSKEKREIFKELFQ--KQR-KVTV
305

WP_002373311
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_002378009
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_002407324
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIEDYLFK--TRR-KVKK
569

WP_002413717
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_010775580
498
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
571

WP_010818269
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_010824395
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVENELTKISYTD--DRGIKA-NFSGKEKEKIEDYLFK--TRR-KVKK
569

WP_016622645
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIEDYLFK--TRR-KVKK
569

WP_033624816
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_033625576
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_033789179
496
SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD--DRGIKA-NFSGKEKEKIFDYLFK--TRR-KVKK
569

WP_002310644
493
SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGQMN-YFSSIEKKEIFHELFE--KNR-KVTK
566

WP_002312694
494
SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_002314015
494
SAVRFIERMNNTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_002320716
494
SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_002330729
493
SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
566

WP_002335161
494
SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_002345439
494
SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_034867970
487
SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD--ERGVKQ-YFSGDEKQQIFKOLFQ--KERgKITV
561

WP_047937432
494
SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD--ERGOMN-YFSSIEKKEIFHELFE--KNR-KVTK
567

WP_010720994
487
SAMRFIQRMTKQDTYLPTEKVLPKNSLFYQKYMIFNELTKVSYKD--ERGVKQ-YFSGDEKQQIFKOLFQ--KERgKITV
561

WP_010737004
487
SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD--ERGVKQ-YFSGDEKQQIFKOLFQ--KERgKITV
561

WP_034700478
487
SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD--ERGVKQ-YFSGDEKQQIFKOLFQ--KERgKITV
561

WP_007209003
491
SAVAFIERMTIKDIYL-NENVLPRHSLIYEKFTVFNELTKVLYAD--DRGVFQ-RFSAEEKEDIFEKLFK--SER-KVTK
563

WP_023519017
486
SAIEFIERMTNQDTYLPKEKVLPKQSLIYORFMIFNELTKVSYTD--ERGKSH-YFSSEQKRKIFNELFK--QHP-RVTE
559

WP_010770040
490
SATKFIERMTNFDTYLPTEKVLPKHSMIYEKYMVYNELTKVSYVD--ERGMNQ-RFSGEEKKQIVEELFK--QSR-KVTK
563

WP_048604708
486
SAELFIERMTNFDLYLPSEKVLPKHSMLYEKYTVYNELTKVTYKD--EQGKVQ-NFSSEEKERIFIDLFK--QHR-KVTK
559

WP_010750235
487
SATKFIQRMINYDTYLPTEKVLPKYSMLYQKYTIFNELTKVAYKD--DRGIKH-QFSSEEKLRIFQELFK--KQR-RVTK
560

AII16583
526
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
600

WP_029073316
507
TADEFIKRMRNFCTYFPDEPVLAKNSLTVSKYEVLNEINKLRIND--------hLIKRDIKDKMLHTLFM--DHK-SISA
575

WP_031589969
507
TADEFIKRMRNFCTYFPDEPVMAKNSLTVSKYEVLNEINKLRIND--------hLIKRDMKDKMLHTLFM--DHK-SISA
575

KDA45870
485
SAEDFIKRMTINDLYLPTEPVLPKHSLLYERYTIFNELAGVRYVT--ENGEAK-YFDAQTKRSIFE-LFK1--DR-KVSE
557

WP_039099354
510
SANEFIKRMTTTDTYLLAEDVLPKQSLIYQRFEVLNELNGLKIDD--QPITTE------LKQAIFTDLFM---QKtSVTV
578

AKP02966
484
SSNKFIRRMTVTDSYLVGEPVLPKNSLIYQRYEVLNELNNIRITEn1KTNPTGSRLTVETKQHIYNELFK--NYK-KITV
560

WP_010991369
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN--DOGKTS-YFSGQEKEQIFNDLFK--QKR-KVKK
566

WP_033838504
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN--DQGKTS-YFSGQEKEQIFNDLFK--QKR-KVKK
566

EHN60060
496
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN--DOGKTS-YFSGQEKEQIFNDLFK--QKR-KVKK
569

EFR89594
262
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN--DOGKTS-YFSGQEKEQIFNDLFK--QKR-KVKK
335

WP_038409211
493
SAIDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DQGKTH-HFSGQEKQQIFNGLFK--QQR-KVKK
566

EFR95520
112
SAIDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DOGKTH-HFSGQEKQQIFNGLFK--QQR-KVKK
185

WP_003723650
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DQGKTN-YFSGREKQQVENDLFK--QKR-KVKK
566

WP_003727705
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DOGKIN-YFSGREKQQIFNDLFK--QKR-KVKK
566

WP_003730785
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DOGKTN-YFSGREKQQIFNDLFK--QKR-KVKK
566

WP_003733029
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

WP_003739838
493
SAVDFIEKMTNKDTYLPKENVLPKHSLYYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDYFK--QKR-KVSK
566

WP_014601172
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

WP_023548323
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DQGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

WP_031665337
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

WP_031669209
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

WP_033920898
493
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
566

AKI42028
496
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
569

AKI50529
496
SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID--DOGKTN-YFSGQEKQQIFNDLFK--QKR-KVKK
569

EFR83390
1
---------------------------------------------------------------IFNDLFK--QKR-KVKK
14

WP_046323366
493
SAIDFIEKMTNKDTYLPKENVLPKHSMCYQKYMVYNELTKIRYTD--DQGKTH-YFSGQEKQQIFNDLFK--QKR-KVKK
566

AKE81011
503
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
577

CUO82355
503
TAEGFIKRMRSYCTYFPDEEVLPKNSLIVSKYEVYNELNKIRVDD--------kLLEVDVKNDIYNELFM--KNK-TVTE
571

WP_033162887
504
TAEGFIERMKNTGTYFPDEPVMAKNSLTVSKFEVLNELNKIRING--------kLIAVETKKELLSDLFM--KNK-TITD
572

AGZ01981
520
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
594

AKA60242
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

AKS40380
487
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
561

4UN5_B
491
SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSGEQKKAIVDLLFK--TNR-KVTV
565

WP_010922251
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_039695303
564
EKLLNYLNKE--FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH
637

WP_045635197
562
KDIIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDAKNEAILENIVHTLTIFEDREMIK
632

5AXW_A
300
KQIAKEILVNe--EDIKGYRVTSTGKPe---FTNLKVYHDIKDITARK ------ENAELLDQIAKILTIYQSSEDIQ
368

WP_009880683
246
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
317

WP_010922251
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_011054416
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_011284745
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_011285506
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_011527619
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_012560673
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_014407541
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGAYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDRGMIE
633

WP_020905136
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_023080005
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNTSLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_023610282
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNTSLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_030125963
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_030126706
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_031488318
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_032460140
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_032461047
562
KQLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_032462016
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_032462936
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_032464890
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_033888930
387
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
458

WP_038431314
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_038432938
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNTSLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_038434062
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

BAQ51233
473
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
544

KGE60162

------------------------------------------------ -----------------------------

KGE60856

------------------------------------------------ -----------------------------

WP_002989955
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_003030002
561
DKLLNYLNKE--FEEFRIVNLTGLDKEnkAFNSSLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR
634

WP_003065552
564
EKLLNYLNKE--FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH
637

WP_001040076
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIK
632

WP_001040078
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_001040080
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040081
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DELDNPDNESILEDIVOTLTLFEDREMIK
635

WP_001040083
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DELDNPDNESILEDIIQTLTLFEDREMIK
635

WP_001040085
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040087
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DELDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040088
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040089
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_001040090
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040091
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040092
562
KQLLDFLAKE--FEEFRIVDVTGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVQTITLFEDREMIK
635

WP_001040094
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIR
632

WP_001040095
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVOTLTLFEDREMIR
632

WP_001040096
563
KDIISELNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVOTLTLFEDREMIR
632

WP_001040097
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIR
632

WP_001040098
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVOTLTLFEDREMIR
632

WP_001040099
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIR
632

WP_001040100
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIR
632

WP_001040104
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040105
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_001040106
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040107
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DELDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040108
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DELDNPDNESILEDIVOTLTLFEDREMIK
635

WP_001040109
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DELDNPDNESILEDIVQTLTLFEDREMIK
635

WP_001040110
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_015058523
562
KOLLDFLAKE--FEEFRIVDVTGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVQTITLFEDREMIK
635

WP_017643650
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DELDNTDNELILEDIVOTLTLFEDREMIR
632

WP_017647151
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DELDNPDNESILEDIVOTLTLFEDREMIK
635

WP_017648376
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DELDNPDNESILEDIVOTLTLFEDREMIK
635

WP_017649527
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_017771611
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_017771984
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

CFQ25032
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

CFV16040
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

KLJ37842
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

KLJ72361
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

KLL20707
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

KLL42645
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_047207273
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_047209694
563
KDIISFLNK---VDGYEGIAIKGIEKQ---FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIR
632

WP_050198062
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_050201642
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_050204027
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVOTLTLFEDREMIK
635

WP_050881965
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_050886065
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

AHN30376
562
KOLLDFLAKE--FEEFRIVDVTGLDKEnkAFNASLGTYHDLKKIL-DK DFLDNPDNESILEDIVQTITLFEDREMIK
635

EAO78426
562
KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

CCW42055
562
KQLLDFLAKE--FEEFRIVDVTGLDKEnkAFNASLGTYHDLEKIL-GK DFLDNPDNESILEDIVQTLTLFEDREMIK
635

WP_003041502
561
DKLLNYLNKE--FEEFRIVNLTGLDKEnkVFNSSLGTYHDLRKIL-NK SFLDNKENAQIIEDIIQTLTLFEDREMIR
634

WP_037593752
562
DKLLNYLNKE--FEEFRIVNLTGLDKEnkAFNSSLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR
635

WP_049516684
562
DKLLNYLNKE--FEEFRIVNLTGLDKEnkAFNASLGTYHDLRKIL-DK SFLDDKVNEKIIEDIIQTLTLFEDREMIR
635

GAD46167
561
DKLLNYLNKE--FEEFRIVNLTGLDKEnkAFNSSLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR
634

WP_018363470
562
EKLLNYLDKE--FPEYRIQDLVGLDKEnkSFNASLGTYHDLKKIL-DK SFLDDKVNEEVIEDIIKTLTLFEDREMIQ
635

WP_003043819
572
KOLKEDYFKK--IECFDSVEIIGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
643

WP_006269658
561
DKLLNYLNKE--FEEFRIVNLTGLDKEnkAFNSSLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR
634

WP_048800889
561
DKLLNYLDKE--FDEFRIVDLTGLDKEnkAFNASLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR
634

WP_012767106
562
KQLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_014612333
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_015017095
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_015057649
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_048327215
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_049519324
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDKEMIE
633

WP_012515931
562
KQLKENYFKK--IECWDSVEITGVEDS---FNASLGTYHDLLKIIQDK DFLDNPDNQKIIEDIILTLTLFEDKKMIS
633

WP_021320964
562
KOLKENYFKK--IECWDSVEITGVEDS---FNASLGTYHDLLKIIQDK DFLDNPDNOKIIEDIILTLTLFEDKKMIS
633

WP_037581760
562
KOLKENYFKK--IECWDSVEITGVEDS---FNASLGTYHDLLKIIQDK DFLDNPDNOKIIEDIILTLTLFEDKKMIS
633

WP_004232481
561
AKLLSYLNNE--FEEFRINDLIGLDKDskSFNASLGTYHDLKKIL-DK SFLDDKTNEQIIEDIVLTLTLFEDRDMIH
634

WP_009854540
562
EKLLNYLNKE--FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH
635

WP_012962174
562
DKFLNYLNKE--FPEYRIQDLIGLDKEnkSFNASLGTYHDLKKIL-DK SFLDDKTNETIIEDIIQTLTLFEDRDMIR
635

WP_039695303
564
EKLLNYLNKE--FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH
637

WP_014334983
561
AKLLSYLNNE--FEEFRINDLIGLDKDskSFNASLGTYHDLKKIL-DK SFLDDKINGQIIEDIVLTLTLFEDRDMIH
634

WP_003099269
562
KOLKEEYFSK--MKCFHTVTILGVEDR---FNASLGTYHDLLKIFKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE
633

AHY15608
562
KQLKEEYFSK--MKCFHTVTILGVEDR---FNASLGTYHDLLKIFKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE
633

AHY17476
562
KQLKEEYFSK--MKCFHTVTILGVEDR---FNASLGTYHDLLKIFKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE
633

ESR09100

------------------------------------------------ -----------------------------

AGM98575
562
KOLKEEYFSK--MKCFHTVTILGVEDR---FNASLGTYHDLLKIFKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE
633

ALF27331
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DELDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_018372492
574
RKLKDFIEKElgYGYIDIDNIKGVEEQ---FNASYTTYQDLLKIIGDK EFLDNEENKDLLEEIIYILTVFEDRKMIE
647

WP_045618028
563
KDIIQYLHN---VDSYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDSKNEAILENIVHTLTIFEDREMIK
633

WP_045635197
562
KDIIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDAKNEAILENIVHTLTIFEDREMIK
632

WP_002263549
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002263887
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002264920
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002269043
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002269448
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002271977
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002272766
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DELDNSKNEKILEDIVLTLILFEDREMIR
634

WP_002273241
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVENASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002275430
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002276448
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002277050
561
KKLRTFLDKN--FDEFRIVDIQGLDKEteTFNASYATYQDLLKVIKDK VEMDNPENAEILENIVLTLTLFEDREMIK
635

WP_002277364
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DELDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002279025
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002279859
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002280230
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002281696
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002282247
561
KKLRTFLDKN--FDEFRIVDIQGLDKEteTFNASYATYQDLLKVIKDK VEMDNPENAEILENIVLTLTLFEDREMIK
635

WP_002282906
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002283846
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002287255
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002288990
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002289641
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002290427
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002295753
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002296423
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002304487
571
DKLLNYLNKE--FEEFRIVNLTGLDKEnkVFNSSLGTYHDLRKIL-NK SFLDNKENEQIIEDIIQTLTLFEDREMIR
644

WP_002305844
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002307203
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002310390
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_002352408
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_012997688
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_014677909
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLILTLFEDREMIR
634

WP_019312892
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_019313659
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_019314093
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_019315370
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_019803776
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_019805234
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_024783594
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_024784288
561
KKLRTFLDKN--FDEFRIVDIQGLDKEteTFNASYATYQDLLKVIKDK VFMDNPENAEILENIVLTLTLFEDREMIK
635

WP_024784666
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_024784894
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_024786433
561
KKLRTFLDKN--FDEFRIVDIQGLDKEteTFNASYATYQDLLKVIKDK VFMDNPENAEILENIVLTLTLFEDREMIK
635

WP_049473442
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DELDNSKNEKILEDIVLTLTLFEDREMIR
634

WP_049474547
561
DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
634

EMC03581
554
DKLMDFLEKE--FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR
627

WP_000428612
565
KDIIQYLHT---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDPNNEEILENIVHTLTIFEDREMIK
635

WP_000428613
563
KDIIQFLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDSKNEEILENIVHTLTIFEDREMIK
633

WP_049523028
562
KDIIHYLHN---VDGYDGIELKGIEKH---FNSSLSTYHDLLKIIKDK EFMDDPKNEEIFENIVHTLTIFEDRVMIK
632

WP_003107102
531
KOLKENYFNK--IRCLDSITISGVEDK---FNASLGTYHDLLNIIKNQ KILDDEQNQDSLEDIVLTLTLFEDEKMIA
602

WP_054279288
564
KOLKEDFFSK--IECFDTVDISGVEDK---FNASLGTYHDLLKIIKDK AFLDNSENENIIEDIILTLTLFEDKEMIA
635

WP_049531101
563
KDLIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK RFMDEPKNQEILENIVHTLTIFEDREMIK
633

WP_049538452
563
KDIIQYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDSKNEEILENIVHTLTIFEDREMIK
633

WP_049549711
563
KDIIHYLHT---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDDSKNEAILENIVHTLTIFEDREMIK
633

WP_007896501
565
KDLKEKYFSQ--IEGLENVDVTGVEGA---FNASLGTYNDLLKIIKDK AFLDDEANAEILEEIVLILTLFQDEKLIE
636

EFR44625
517
KDLKEKYFSQ--IEGLENVDVTGVEGA---FNASLGTYNDLLKIIKDK AFLDDEANAEILEEIVLILTLFQDEKLIE
588

WP_002897477
562
KDIIHYLHN---VDGYDGIELKGIEKQ---FNANLSTYHDLLKITKDK EFMDDPKNEEILENIVHTLTIFEDREMIK
632

WP_002906454
562
KDIIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDNPKNGEILENIIHTLTIFEDREMIK
632

WP_009729476
563
KDIIQFLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK AFMDDAKNEAILENIVHTLTIFEDREMIK
633

CQR24647
562
KKILNFLDKN--FDEFRITDIQGLDNEtgNFNASYGTYHDLLKIIGDK EFMDSSDNVDVLEDIVLSLTLFEDREMIK
636

WP_000066813
565
KDIIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK AFMDDSKNEEILENIIHTLTIFEDREMIK
635

WP_009754323
563
KDIIHYLHN---VDGYDGIELKGIEKQ---FNASLSTYHDLLKIIKDK EFMDNHKNQEILENIVHTLTIFEDREMIK
633

WP_044674937
562
KDIKAYL-EN--SNGYAGVELKGLEEQ---FNASLPTYHDLLKILRDK AFIDAEENQEILEDIVLTLTLFEDREMIR
632

WP_044676715
561
EKLMDFLGKE--FDEFRIVDLLGLDKDnkSFNASLGTYHDLKKIV-SK DLLDNPENEDILENVVLTLTLFEDREMIR
634

WP_044680361
561
EKLMDFLGKE--FDEFRIVDLLGLDKDnkSFNASLGTYHDLKKIV-SK DLLDNPENEDILENVVLTLTLFEDREMIR
634

WP_044681799
562
KDIKAYL-EN--SNGYAGVELKGLEEQ---FNASLPTYHDLLKILRDK AFIDAEENQEILEDIVLTLTLFEDREMIR
632

WP_049533112
561
DKLLNYLGKE--FDEFRIVDLTGLDKEnkVFNSSLGTYHDLRKIL-DK SFLDNKENEQIIEDIIQTLTLFEDREMIR
634

WP_029090905
541
TSLKKWLAEH---EHMTVSVVQGTQKEt-EFATSLQAFHRFVKIF-DR ETVSNPANEEMFEKIIYWSTVFEDKKIMR
612

WP_006506696
568
KKLKNWLVNNqcCS--KDAEIKGFQKEn-QFSTSLTPWIDFTNIFGKI --DQSNFDLIENIIYDLTVFEDKKIMK
637

AIT42264
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

WP_034440723
568
NOLVKYIENK---EQIIAPEIKGIEDS---FNSNYSTYIDLSKIPDMK --LLEKDEDEILEEIIKILTIFEDRKMRK
637

AKQ21048
562
KQLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

WP_004636532
563
KDIANYLEQ---YGYVDGTDIKGVEDK---FNASLSTYNDLAKIDGAK AYLDDPEYADVWEDIIKILTIFEDKAMRK
633

WP_002364836
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_016631044
521
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
592

EMS75795
306
KKLQQFLSAN--YN-IEDAEILGVDKA---FNSSYATYHDELDLAKPN ELLEQPEMNAMFEDIVKILTIFEDREMIR
381

WP_002373311
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_002378009
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_002407324
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_002413717
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR
641

WP_010775580
572
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
643

WP_010818269
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR
641

WP_010824395
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_016622645
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR
641

WP_033624816
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR
641

WP_033625576
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_033789179
570
KDIIQFYRNE--YN-TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRORIR
641

WP_002310644
567
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
641

WP_002312694
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_002314015
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_002320716
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_002330729
567
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
641

WP_002335161
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_002345439
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_034867970
562
KKLONFLYTH--YH-IENAQIFGIEKA---FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK
637

WP_047937432
568
KDLQEFLYLK--YD-IKHAELSGIEKA---FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK
642

WP_010720994
562
KKLONFLYTH--YH-IENAQIFGIEKA---FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK
637

WP_010737004
562
KKLONFLYTH--YH-IENAQIFGIEKA---FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK
637

WP_034700478
562
KKLONFLYTH--YH-IENAQIFGIEKA---FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDROMIK
637

WP_007209003
564
KKLENYLRIE1---SISSPSVKGIEEQ---FNANFGTYLDLKKEDELH PYLDDEKYQDTLEEVIKVLTVFEDRSMIQ
634

WP_023519017
560
KOLRKFLELN--EQ-IDSTEIKGIETS---FNASYSTYHDLLKLS--- TLLDDPDMTTMFEEIIKILTIFEDREMIR
631

WP_010770040
564
KLLEKFLSNE--FG-LVDVAIKGIE-T--SFNAGYGTYHDELKIGITR EQLDKEENSETLEEIVKILTVFEDRKMIR
634

WP_048604708
560
KDLSNFLRNE--YN-LDDVIIDGIE-N--KFNASENTYHDFLKLKIDP KVLDDPANEPMFEEIVKILTIFEDRKMLR
630

WP_010750235
561
KKLQHFLSAN--YN-IEDAEILGVDKV---FNSSYATYHDFLELAKPY ELLEQPEMEEMFEDIVKIITIFEDREMVR
636

AII16583
601
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
672

WP_029073316
576
NAMKKWLVKNqyFSNTDDIKIEGFQKEn-ACSTSLTPWIDFTKIFGEI ----NNSNYELIEKIIYDVTVFEDKKILR
647

WP_031589969
576
NAMKKWLVKNqyFSNTDDIKIEGFQKEn-ACSTSLTPWIDFTKIFGKI ----NESNYDFIEKIIYDVTVFEDKKILR
647

KDA45870
558
KMVIKHLKVV--MPAIRIQALKGLDNGk--FNASYGTYKDLVDMGVAP ELLNDEVNSEKWEDIIKTLTIFEGRKLIK
630

WP_039099354
579
KNIQDYLVSEK--RYASRPAITGLSDEnk-FNSRLSTYHDLKTIVGDA --VDDVDKQADLEKCIEWSTIFEDGKIYS
650

AKP02966
561
KKLTKWLIAQg---YYKNPILIGLSQKd-EFNSTLTTYLDMKKIFGSS -FMENNKNYNQIEELIEWLTIFEDKQILN
632

WP_010991369
567
KDLELFLRNM--SH-VESPTIEGLE-D--SENSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK
637

WP_033838504
567
KDLELFLRNM--SH-VESPTIEGLE-D--SENSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK
637

EHN60060
570
KDLELFLRNM--SH-VESPTIEGLE-D--SENSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK
640

EFR89594
336
KDLELFLRNM--SH-VESPTIEGLE-D--SFNSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK
406

WP_038409211
567
KDLERFLYTI--NH-IESPTIEGVE-D--AFNSSFATYHDLQKGGVTQ EILDNPLNADMLEEIVKILTVFEDKRMIK
637

EFR95520
186
KDLERFLYTI--NH-IESPTIEGVE-D--AFNSSFATYHDLQKGGVTQ EILDNPLNADMLEEIVKILTVFEDKRMIK
256

WP_003723650
567
KDLELFLRNI--NH-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK
637

WP_003727705
567
KDLELFLRNI--NH-IESPTIEGLE-D--SFNASYATYHDLLKVGLKQ EILDNPLNTEILEDIVKILTVFEDKRMIK
637

WP_003730785
567
KDLELFLRNI--NH-IESPTIEGLE-D--SFNASYATYHDLLKVGLKQ EILDNPLNTEILEDIVKILTVFEDKRMIK
637

WP_003733029
567
KDLELFLRNI--NQ-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
637

WP_003739838
567
KDLEQFLRNM--SH-IESPTIEGLE-D--SENSSYATYHDLLKVGIKQ EVLENPLNTEMLEDIVKILTVFEDKRMIK
637

WP_014601172
567
KDLELFLRNI--NH-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK
637

WP_023548323
567
KDLELFLRNI--NH-VESPTIEGLE-D--SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
637

WP_031665337
567
KDLELFLRNI--NQ-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
637

WP_031669209
567
KDLELFLRNI--NQ-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
637

WP_033920898
567
KDLELFLRNI--NH-VESPTIEGLE-D--SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
637

AKI42028
570
KDLELFLRNI--NH-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK
640

AKI50529
570
KDLELFLRNI--NH-VESPTIEGLE-D--SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
640

EFR83390
15
KDLELFLRNI--NQ-IESPTIEGLE-D--SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK
85

WP_046323366
567
KDLELFLYNM--NH-VESPTVEGVE-D--AFNSSFTTYHDLQKVGVPQ EILDDPLNTEMLEEIIKILTVFEDKRMIN
637

AKE81011
578
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
649

CUO82355
572
KKLKNWLVNNqcCR--KDAEIKGFQKEn-QFSTSLTPWIDFTNIFGKI ----DQSNEDLIEKIIYDLTVFEDKKIMK
641

WP_033162887
573
KKLKDWLVTHqyYDINEELKIEGYQKD1-QFSTSLAPWIDFTKIFGEI ----NASNYQLIEKIIYDISIFEDKKILK
644

AGZ01981
595
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
666

AKA60242
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
633

AKS40380
562
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DELDNEENEDILEDIVLTLTLFEDREMIE
633

4UN5_B
566
KOLKEDYFKK--IECFDSVEISGVEDR---FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE
637

WP_010922251
634

embedded image

702

WP_039695303
638
ERLOKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG---SANRNFMQLINDDTL
706

WP_045635197
633
QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG---KINRNFMQLINDDGL
701

5AXW_A
369
EELTNLNSELTQEEIEQISN1KGYTGTHNLSLKAINLILDE ---------LW -------TNDNQIAIFNRLKL
426

WP_009880683
318
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
386

WP_010922251
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_011054416
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_011284745
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_011285506
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_011527619
634
ERLKTYAHLFDDKVMKOLKR-RRYTVWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_012560673
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDELK -DGf---ANRNFMQLIHDDSL
702

WP_014407541
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_020905136
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_023080005
634
ERLKKYANLFDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_023610282
634
ERLKKYANLFDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_030125963
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_030126706
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_031488318
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_032460140
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_032461047
634
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_032462016
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_032462936
634
ERLKKYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_032464890
634
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_033888930
459
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
527

WP_038431314
634
ERLKTYAHLEDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_038432938
634
ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_038434062
634
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

BAQ51233
545
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
613

KGE60162

----------------------------------------- ----------- ---------------------

KGE60856

----------------------------------------- ----------- ---------------------

WP_002989955
634
ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_003030002
635
QRLOKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
703

WP_003065552
638
ERLOKYSDIFTADQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG---SANRNFMQLINDDTL
706

WP_001040076
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040078
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040080
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040081
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040083
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040085
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040087
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040088
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040089
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040090
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040091
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040092
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDR ESQKTILDYLI SDG---RANRNFMQLINDDGL
704

WP_001040094
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040095
633
KRLDIYKDFFTESQLKKLYR-RHYTGWERLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040096
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040097
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040098
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040099
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040100
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_001040104
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040105
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_001040106
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_001040107
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_001040108
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_001040109
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_001040110
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_015058523
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDR ESQKTILDYLI SDG---RANRNFMQLINDDGL
704

WP_017643650
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_017647151
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---KSNRNFMQLIHDDGL
704

WP_017648376
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---KSNRNFMQLIHDDGL
704

WP_017649527
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNEMQLINDDGL
704

WP_017771611
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMOLIHDDGL
704

WP_017771984
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

CFQ25032
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

CFV16040
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

KLJ37842
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

KLJ72361
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

KLL20707
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
718

KLL42645
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_047207273
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_047209694
633
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
701

WP_050198062
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_050201642
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_050204027
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG---RANRNFMQLIHDDGL
704

WP_050881965
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

WP_050886065
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

AHN30376
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDR ESQKIILDYLI SDG---RANRNFMQLINDDGL
704

EAO78426
636
KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG---RSNRNFMQLINDDGL
704

CCW42055
636
KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG---SANRNFMQLIKDAGL
704

WP_003041502
635
QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
703

WP_037593752
636
QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
704

WP_049516684
636
QRLOKYSDIFTTQQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
704

GAD46167
635
QRLOKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
703

WP_018363470
636
QRLOKYSDIFTKQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG---SANRNFMQLINDDAL
704

WP_003043819
644
ERLKTYAHLFDDKVMKOLKR-RHYTGWGRLSRKMINGIRDK QSGKTILDELK -DGf---SNRNFMQLIHDDSL
712

WP_006269658
635
QRLOKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
703

WP_048800889
635
QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILEYLV DDG---YANRNFMQLINDDTL
703

WP_012767106
634
ERLKKYANLFDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_014612333
634
ERLKKYANLEDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_015017095
634
ERLKTYAHLEDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFIQLIHDDSL
702

WP_015057649
634
ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLINDDSL
702

WP_048327215
634
ERLKTYAHLFDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFIQLIHDDSL
702

WP_049519324
634
ERLKTYAHLEDDKVMKOLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFIQLIHDDSL
702

WP_012515931
634
KRLDQYAHLFDKVVINKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDSEL
702

WP_021320964
634
KRLDQYAHLFDKVVINKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDSEL
702

WP_037581760
634
KRLDQYAHLFDKVVLNKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDSEL
702

WP_004232481
635
ERLOKYSDIFTSQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDFLI DDG---DANRNFMQLINDDSL
703

WP_009854540
636
ERLOKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG---SANRNFMQLINDDTL
704

WP_012962174
636
QRLQKYSDIFTPQQLKKLER-RHYTGWGRLSYKLINGIRNK ENGKSILDYLI DDG---YANRNFMQLISDDTL
704

WP_039695303
638
ERLOKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG---SANRNFMQLINDDTL
706

WP_014334983
635
ERLQKYSDFFTSQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDFLI DDG---HANRNEMQLINDESL
703

WP_003099269
634
RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv---ANRNFMQLINDSSL
702

AHY15608
634
RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv---ANRNFMQLINDSSL
702

AHY17476
634
RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv---ANRNFMQLINDSSL
702

ESR09100

----------------------------------------- ----------- ---------------------

AGM98575
634
RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv---ANRNFMQLINDSSL
702

ALF27331
635
KRLENYSDLLTKEQVKNLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_018372492
648
KRLSELNIPFENKIIKKLAR-KKYTGWGNLSRKLIDGIRNR ETNRTILGHLI DDGf---SNRNLMQLINDDGL
716

WP_045618028
634
QRLAHYASIFDEKVIKALTR-RHYTGWGKLSAKLINGIYDK QSKKTILDYLI DDG---EINRNFMQLINDDGL
702

WP_045635197
633
QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG---KINRNFMQLINDDGL
701

WP_002263549
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002263887
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002264920
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002269043
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002269448
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002271977
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002272766
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002273241
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002275430
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG---NSNRNFMQLINDDAL
703

WP_002276448
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002277050
636
QRLAKYADVEDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA---QSNRNLMQLITDDNL
704

WP_002277364
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002279025
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002279859
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002280230
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002281696
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002282247
636
QRLAKYADVEDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA---QSNRNLMQLITDDNL
704

WP_002282906
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002283846
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002287255
635
KRLENYSDLLIKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002288990
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002289641
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002290427
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002295753
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002296423
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002304487
645
QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRDK QSNKTILGYLI DDG---YSNRNFMQLINDDAL
713

WP_002305844
635
KRLENYSDLLIKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002307203
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG---NSNRNFMQLINDDAL
703

WP_002310390
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_002352408
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG---NSNRNFMQLINDDAL
703

WP_012997688
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_014677909
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_019312892
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_019313659
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_019314093
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG---NSNRNFMQLINDDAL
703

WP_019315370
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG---NSNRNFMQLINDDAL
703

WP_019803776
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_019805234
635
KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_024783594
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_024784288
636
QRLAKYADVEDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA---QSNRNLMQLITDDNL
704

WP_024784666
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_024784894
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_024786433
636
QRLAKYADVFDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA---QSNRNLMQLITDDNL
704

WP_049473442
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

WP_049474547
635
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
703

EMC03581
628
KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG---NSNRNFMQLINDDAL
696

WP_000428612
636
QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSSKLINGIRDK QTGKTILDYLM DDG---YNNRNFMQLINDDEL
704

WP_000428613
634
QRLAQYDSLFDEKVIKALIR-RHYTGWGKLSAKLIDGICDK QTGNTILDYLI DDG---KNNRNFMQLINDDGL
702

WP_049523028
633
QRLNQYDSIFDEKVIKALTR-RHYTGWGKLSAKLINGIRDK KTSKTILDYLI DDG---YSNRNFMQLINDDGL
701

WP_003107102
603
KRLSKYESIFDPSILKKLKK-RHYTGWGRLSQKLINGIRDK QTGKTILDFLI -DGq---ANRNFMQLINDPSL
671

WP_054279288
636
NRLAVYEDLFDQNVLKOLKR-RHYTGWGRLSKOLINGMRDK HTGKTILDFLK -DGf---INRNFMQLINDDNL
704

WP_049531101
634
QRLAQYASIFDEKVIKTLTR-RHYTGWGKLSAKLINCIRDR KTGKTILDYLI DDG---YNNRNFMQLINDDGL
702

WP_049538452
634
QRLAQYDSIFDEKVIKALTR-RHYTGWGKLSAKLINGIRDK QTGKTILDYLI DDG---YSNRNEMQLINDDGL
702

WP_049549711
634
QRLAQYDSLFDKKVIKALTR-RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG---EINRNFMQLINDDGL
702

WP_007896501
637
KRLAKYANLFEKSVLKKLRK-RHYRGWGRLSRQLIDGMKDK ASGKTILDFLK -DDf---ANRNFIQLINDSSL
705

EFR44625
589
KRLAKYANLFEKSVLKKLRK-RHYRGWGRLSRQLIDGMKDK ASGKTILDFLK -DDf---ANRNFIQLINDSSL
657

WP_002897477
633
QRLAQYDTLFDEKVIKALTR-RHYTGWGKLSAKLINGIRDK QSGKTILDYLI DDD---KINRNFMQLINDDGL
701

WP_002906454
633
QRLAQYDTLFDEKVIKALTR-RHYTGWGKLSAKLINGIRDK QTGKTILEYLI DDG---DCNRNFMQLINDDGL
701

WP_009729476
634
QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGISDK QTGNTILDYLI DDG---EINRNFMQLINDDGL
702

COR24647
637
QRLLKYEDIFSKKVIANLTR-RHYTGWGRLSAKLINGIKDK HSRKTILDYLI DDG---HSNRNFMQLINDDNL
705

WP_000066813
636
QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGIRDK KSGKTILDYLI DDG---EINRNFMQLIHDDGL
704

WP_009754323
634
QRLAQYDSIFDEKVIKALTR-RHYTGWGKLSAKLINGICDK KTGKTILDYLI DDG---YNNRNFMQLINDDGL
702

WP_044674937
633
KRLEKYKDILTEEQRKKLER-RHYTGWGRLSAKLINGILDK VTRKTILGYLI DDG---TSNRNFMQLINDDTL
701

WP_044676715
635
KRLEKYKDVLTEEQRKKLER-RHYTGWGRLSAKLINGIRDK VTRKTILDYLI DDG---TSNRNFMQLINDDTL
703

WP_044680361
635
KRLEKYKDVLTEEQRKKLER-RHYTGWGRLSAKLINGIRDK VTRKTILDYLI DDG---TSNRNFMQLINDDTL
703

WP_044681799
633
KRLEKYKDILTEEQRKKLER-RHYTGWGRLSAKLINGILDK VTRKTILGYLI DDG---TSNRNFMQLINDDTL
701

WP_049533112
635
QRLOKYSDIFTKAQLKKLER-CHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG---YANRNFMQLINDDAL
703

WP_029090905
613
RKLSEYPQLTEQQQVOLAQV--RFRGWGRLSQRLINRIKTP EDHKLSINEIL ------QTNENFMQIIRNKDY
682

WP_006506696
638
RRLKKKYALPDDKVKQILKL--KYKDWSRLSKKLLDGIVAD SV--TVLDVLE -------SRLNLMEIINDKDL
705

AIT42264
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_034440723
638
RQLMKFKDKLSEKAINQLSK-KHYTGWGQLSEKLINGIRDE QSNKTILDYLI DNGcpkNMNRNFMQLINDDTL
710

AKQ21048
634
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

WP_004636532
634
KQLQTYSDTLSPEILKKLER-KHYTGWGRFSKKLINGLRDE GSNKTILDYLK DEGssgPTNRNFMQLIRDNTL
706

WP_002364836
642
TQLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILGYLI DDGvskHYNRNFMQLINDSQL
714

WP_016631044
593
TQLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvskHYNRNFMQLINDSQL
665

EMS75795
382
TQLKKYQSVLGDGFFKKLVK-KHYTGWGRLSERLINGIRDK KTNKTILDYLI DDDfpyNRNRNFMQLINDDSL
454

WP_002373311
642
TOLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvskHYNRNFMQLINDSQL
714

WP_002378009
642
TOLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvskHYNRNFMQLINDSQL
714

WP_002407324
642
TOLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvskHYNRNFMQLINDSQL
714

WP_002413717
642
TOLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvSkHYNRNFMQLINDSQL
714

WP_010775580
644
TOLSTFKGOFSEEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGVSKHYNRNFMQLINDSQL
716

WP_010818269
642
TOLSTFKGOFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILGYLI DDGvskHYNRNFMQLINDSQL
714

WP_010824395
642
TOLSTFKGOFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvskHYNRNFMQLINDSQL
714

WP_016622645
642
TOLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvSkHYNRNFMQLINDSQL
714

WP_033624816
642
TQLSTFKGQFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvskHYNRNFMQLINDSQL
714

WP_033625576
642
TQLSTFKGOFSAEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvskHYNRNFMQLINDSQL
714

WP_033789179
642
TOLSTFKGQFSEEVLKKLER-KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvskHYNRNFMQLINDSQL
714

WP_002310644
642
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
714

WP_002312694
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
715

WP_002314015
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
715

WP_002320716
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
715

WP_002330729
642
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
714

WP_002335161
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
715

WP_002345439
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNCMQLINDDSL
715

WP_034867970
638
HQLSKYQEVFGEKLLKEFAR-KHYTGWGRFSAKLIHGIRDR KINKTILDYLI DDDvpaNRNRNLMQLINDEHL
710

WP_047937432
643
TRLSHHEATLGKHIIKKLTK-KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL
715

WP_010720994
638
HQLSKYQEVFGEKLLKEFAR-KHYTGWGRFSAKLIHGIRDR KINKTILDYLI DDDvpaNRNRNLMQLINDEHL
710

WP_010737004
638
HQLSKYQEVFGEKLLKEFAR-KHYTGWGRFSAKLIHGIRDR KINKTILDYLI DDDvpaNRNRNLMQLINDEHL
710

WP_034700478
638
HQLSKYQEVFGEKLLKEFAR-KHYTGWGRFSAKLIHGIRDR KTNKTILDYLI DDDvpaNRNRNLMQLINDEHL
710

WP_007209003
635
NQLEQLPLNLSTKTIKALSR-RKYTGWGRLSARLIDGIHDK NSGKTILDYLI DESdsyIVNRNFMQLINDDHL
707

WP_023519017
632
EQLKPYETVLGLPAIKKLAK-KHYTGWGRLSEKMIQGMREK QSRKTILDYLI DDDfpcNRNRNFMQLINDDHL
704

WP_010770040
635
EQLKKYTYLFDEEVLKKLER-RHYTGWGRLSAKLLIGIKEK RTHKTILDYLI DDGgkqPINRNLMQLINDSDL
707

WP_048604708
631
EQLSKFSDRLSEKTIKDLER-RHYTGWGRLSAKLINGIHDK QSNKTILDYLI DDApkkNINRNFMQLINDNRL
703

WP_010750235
637
TQLKKYQRILGEEIFKKLVK-KKYTGWGRLSKRLINGIRDQ KINKTILDYLI DDDfpyNRNRNFMQLINDDHL
709

AII16583
673
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
741

WP_029073316
648
RRLKKEYDLDEEKIKKILKL--KYSGWSRLSKKLLSGIKTK RTPETVLEVME -------TNMNLMQVINDEKL
717

WP_031589969
648
RRLKKEYDLDEEKIKKILKL--KYSGWSRLSKKLLSGIKTK RTPETVLEVME -------TNMNLMQVINDEKL
717

KDA45870
631
RRLENYRDFLGEDILRKLSR-KKYTGWGRLSAKLLDGIYDK KTHKTILDCLM EDYS-----QNFMQLINDDTY
698

WP_039099354
651
AKLNEIDWLTDQQRVOLAAK--RYRGWGRLSAKLLTQIVN- ANGQRIMDLLW -------TTDNFMRIVHSE--
712

AKP02966
633
EKLHSSNYSYTSDQIKKISN-MRYKGWGRLSKKILTCITTE TNTPKSLQLSN -DLm-wTTNNNFISIISNDKY
706

WP_010991369
638
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_033838504
638
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

EHN60060
641
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
709

EFR89594
407
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
475

WP_038409211
638
EQLQSFSDVLDGTILKKLER-RHYTGWGRLSAKLLTGIRDK HSHLTILDYLM DDG----LNRNLMQLINDSNL
706

EFR95520
257
EQLQSFSDVLDGTILKKLER-RHYTGWGRLSAKLLTGIRDK HSHLTILDYLM DDG----LNRNLMQLINDSNL
325

WP_003723650
638
EQLQQFSDVLDGGVLKKLER-RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_003727705
638
EQLEQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_003730785
638
EQLEQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_003733029
638
EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_003739838
638
EQLQQFSDVLDGAVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_014601172
638
EQLQQFSDVLDGGVLKKLER-RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_023548323
638
EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_031665337
638
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILEYLM DDG----LNRNLMQLINDSNL
706

WP_031669209
638
EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

WP_033920898
638
EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
706

AKI42028
641
EQLQQFSDVLDGGVLKKLER-RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG----LNRNLMQLINDSNL
709

AKI50529
641
EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG----LNRNLMQLINDSNL
709

EFR83390
86
EQLQQFSDVLDGVVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILEYLM DDG----LNRNLMQLINDSNL
154

WP_046323366
638
ERLQEFSNVLDEAVLKKLER-RHYTGWGRLSAKLLIGIRDK ESHLTILDYLM DDK----HNRNLMQLINDSNL
706

AKE81011
650
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMOLIHDDSL
718

CUO82355
642
RRLKKKYALPDDKIKQILKL--KYKDWSRLSKKLLDGIVAD SV--TVLDVLE -------SRLNLMEIINDKEL
709

WP_033162887
645
RRLKKVYQLDDLLVDKILKL--NYTGWSRLSEKLLTGMTAD KA--TVLFVLE -------SNKNLMEIINDEKI
712

AGZ01981
667
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
735

AKA60242
634
ERLKTYAHLFDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

AKS40380
634
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
702

4UN5_B
638
ERLKTYAHLEDDKVMKOLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNFMQLIHDDSL
706

WP_010922251
703

embedded image

777

WP_039695303
707
PFKQIIQKSQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-GNPDNIVIEMARENQ TTNRGRSQS
780

WP_045635197
702
SFKEIIQKAQVIG-KTDD-VKQVVQELSGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS
775

5AXW_A
427
VPKKVDLSQQKEI---PT---TLVDDFILSPVVKRSFIQSIKVINAIIKKYG--LPNDIIIELAREKN --------S
487

WP_009880683
387
TFKEDLQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
461

WP_010922251
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_011054416
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_011284745
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_011285506
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_011527619
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_012560673
703
TFKEDLQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_014407541
703
TFKEDIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS
776

WP_020905136
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_023080005
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTOKGQKNS
776

WP_023610282
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS
776

WP_030125963
703
TFKEDLQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_030126706
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_031488318
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_032460140
703
TFKEDLQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_032461047
703
TFKEDLQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_032462016
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_032462936
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_032464890
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_033888930
528
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
602

WP_038431314
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_038432938
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS
776

WP_038434062
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKIVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

BAQ51233
614
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
688

KGE60162

-------------------------------------------------------------------- ---------

KGE60856

-------------------------------------------------------------------- ---------

WP_002989955
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

WP_003030002
704
SFKEEIARAQIIG-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ MTDKGRRNS
777

WP_003065552
707
PFKQIIQKSQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-DNPDNIVIEMARENQ TTNRGRSQS
780

WP_001040076
702
SFKPIIDKARTGS-HSDN-LKEVIGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040078
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040080
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040081
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040083
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040085
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040087
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040088
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040089
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040090
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVVG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040091
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040092
705
SFKSIISKAQSGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040094
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040095
702
SFKPIIDKARTGS-HLDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040096
702
SFKPIIDKARTGS-HLDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040097
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRL
775

WP_001040098
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040099
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040100
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_001040104
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040105
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_001040106
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_001040107
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_001040108
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_001040109
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_001040110
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_015058523
705
SFKSIISKAQSGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_017643650
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRL
775

WP_017647151
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_017648376
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_017649527
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TINQGRRNS
778

WP_017771611
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_017771984
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

CFQ25032
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

CFV16040
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

KLJ37842
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

KLJ72361
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

KLL20707
719
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
792

KLL42645
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNKGRRNT
778

WP_047207273
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_047209694
702
SFKPIIDKARTGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTAKGLSRS
775

WP_050198062
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_050201642
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_050204027
705
SFKPIIDKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQVVVEMARENQ TTNQGRRNT
778

WP_050881965
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

WP_050886065
705
SEKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

AHN30376
705
SFKSIISKAQSGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

EAO78426
705
SFKSIISKAQAGS-HSDN-LKEVVGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIVVEMARENQ TTNQGRRNS
778

CCW42055
705
SFKSIISKAQSGS-HSDN-LKEVVSELAGSPAIKKGILQSLKIVDELVKVMG-YKPEQIVVEMARENQ TTNQGRRNS
778

WP_003041502
704
SFKEEIAKAQIIG-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ TTDRGRRNS
777

WP_037593752
705
SFKEEIARAQIIG-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ TTDKGRRNS
778

WP_049516684
705
SFKEEIARAQIIG-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ TTDKGRRNS
778

GAD46167
704
SFKEEIARAQIIG-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ TTDKGRRNS
777

WP_018363470
705
SFKQIIQEAQVVG-DVDD-IETVVHDLPGSPAIKKGILQSVKIVDELIKVMG-DNPDNIVIEMARENQ TTNRGRSQS
778

WP_003043819
713
TFKEEIEKAQVSG-QGDS-LHEQIADLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTTKGLQQS
786

WP_006269658
704
SFKEEIARAQIID-DVDD-IANVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANIIIEMARENQ TTDKGRRNS
777

WP_048800889
704
PFKQIIKDAQAID-DVDD-IELIVHDLPGSPAIKKGILQSIKIVDELVKVMG-YNPDNIVIEMARENQ TTTKGRRNS
777

WP_012767106
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS
776

WP_014612333
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTOKGQKNS
776

WP_015017095
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTOKGQKNS
776

WP_015057649
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTOKGQKNS
776

WP_048327215
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS
776

WP_049519324
703
TFKEAIQKAQVSG-QGHS-LHEQIANLAGSPAIKKGILQSVKVVDELVKVMG-HKPENIVIEMARENQ TTOKGQKNS
776

WP_012515931
703
SFIDEIAKAQVIG-KTEY-SKDLVGNLAGSPAIKKGISQTIKIVDELVKIMG-YLPQQIVIEMARENQ TTAQGIKNA
776

WP_021320964
703
SFIDEIAKAQVIG-KTEY-SKDLVGNLASSPAIKKGISQTIKIVDELVKIMG-YLPQQIVIEMARENQ TTAQGIKNA
776

WP_037581760
703
SFIDEIAKAQVIG-KTEY-SKDLVGNLAGSPAIKKGISQTIKIVDELVKIMG-YLPQQIVIEMARENQ TTAQGIKNA
776

WP_004232481
704
SFKTTIQEAQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPQNIVIEMARENQ ITGYGRNRS
777

WP_009854540
705
PFKQIIQKSQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-DNPDNIVIEMARENQ TTNRGRSQS
778

WP_012962174
705
PFKQIIKDAQIIG-DIDD-VTSVVRELPGSPAIKKGILQSVKIVDELVKVMG-HNPDNIVIEMARENQ TTNRGRNOS
778

WP_039695303
707
PFKQIIQKSQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-GNPDNIVIEMARENQ TTNRGRSQS
780

WP_014334983
704
SFKTIIQEAQVVG-DVDD-IEAVVHDLPGSPAIKKGILQSVKIVDELVKVMG-DNPDNIVIEMARENQ TTGYGRNKS
777

WP_003099269
703
DFAKIIKNEQEKTiKNES-LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG-QNPDNIVIEMARENQ STMQGIKNS
777

AHY15608
703
DFAKIIKNEQEKTiKNES-LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG-QNPDNIVIEMARENQ STMQGIKNS
777

AHY17476
703
DFAKIIKNEQEKTiKNES-LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG-QNPDNIVIEMARENQ STMQGIKNS
777

ESR09100

-------------------------------------------------------------------- ---------

AGM98575
703
DFAKIIKNEQEKTiKNES-LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG-QNPDNIVIEMARENQ STMQGIKNS
777

ALF27331
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_018372492
717
DFKEIIRKAQTIE-NIDT-NQALVSSLPGSPAIKKGILQSLNIVDEIIAIMG-YAPTNIVIEMARENQ TTQKGRDNS
790

WP_045618028
703
SFKEIIQKAQVVG-KIND-VKQVVQELPGSPAIKKGILQSIKLVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS
776

WP_045635197
702
SFKEIIQKAQVIG-KTDD-VKQVVQELSGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS
775

WP_002263549
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002263887
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002264920
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002269043
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002269448
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRONS
777

WP_002271977
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002272766
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002273241
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTKQGRRNS
777

WP_002275430
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002276448
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTKQGRRNS
777

WP_002277050
705
TFKDDIVKAQYVD-NSDD-LHQVVQSLAGSPAIKKGILQSLKIVDELVKVMG-KEPEQIVVEMARENQ TTAKGRRNS
778

WP_002277364
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002279025
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002279859
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002280230
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTKQGRRNS
777

WP_002281696
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002282247
705
TFKDDIVKAQYVD-NSDD-LHQVVQSLAGSPAIKKGILQSLKIVDELVKVMG-KEPEQIVVEMARENQ TTAKGRRNS
778

WP_002282906
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002283846
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002287255
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002288990
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002289641
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002290427
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSLAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002295753
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTKQGRRNS
777

WP_002296423
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002304487
714
SFKEEIAKAQVIG-EMDG-LNQVVSDIAGSPAIKKGILQSLKIVDELVKVMG-HNPANIVIEMARENQ TTAKGRRSS
787

WP_002305844
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTKQGRRNS
777

WP_002307203
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002310390
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSLAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_002352408
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNOGORNS
777

WP_012997688
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_014677909
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019312892
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019313659
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019314093
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019315370
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019803776
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_019805234
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSLAIKKGILQNLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_024783594
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_024784288
705
TFKDDIVKAQYVD-NSDD-LHQVVQSLAGSPAIKKGILQSLKIVDELVKVMG-KEPEQIVVEMARENQ TTAKGRRNS
778

WP_024784666
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_024784894
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_024786433
705
TFKDDIVKAQYVD-NSDD-LHQVVQSLAGSPAIKKGILQSLKIVDELVKVMG-KEPEQIVVEMARENQ TTAKGRRNS
778

WP_049473442
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

WP_049474547
704
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
777

EMC03581
697
SFKEEIAKAQVIG-ETDN-LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIVVEMARENQ FTNQGRRNS
770

WP_000428612
705
SFKEIIKKAQVVG-KTDD-VKQVVQELPGSPAIKKGILQSIKLVDELVKVMG-HEPESIVIEMARENQ TTARGKKNS
778

WP_000428613
703
SFKEITQKAQVVG-KTDD-VKQVVQELPGSPAIKKGILQSIKIVDELVKVMG-HTPESIVIEMARENQ TTARGKKNS
776

WP_049523028
702
SFKETIQKAQVVG-ETND-VKQVVQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESVVIEMARENO TTNKGKSKS
775

WP_003107102
672
DFASIIKEAQEKTIKSEK-LEETIANLAGSPAIKKGILQSVKIVDEVVKVMG-YEPSNIVIEMARENQ STORGINNS
746

WP_054279288
705
SFKEEIKKAQEGG-LKDS-INDQIRDLAGSPAIKKGILQTINIVDEIVKIMG-KAPQHIVVEMARDVQ KTDIGVKQS
778

WP_049531101
703
SFKEIIQESQVVG-KPDD-VKQIVQELPGSSAIKKGILQSIKLVDELVKVMG-HDPESIVIEMARENQ TTARGKKNS
776

WP_049538452
703
SFKEIIQKAQVFG-KIND-VKQVVQELPGSPAIKKGILQSIKIVEELVKVMG-HEPESIVIEMARENQ TTTRGKKNS
776

WP_049549711
703
SFKKIIQKSQVVG-ETDD-VKQVVRELPGSPAIKKGILQSIKIVDELVKVMD-HAPESIVIEMARENQ TTARGKKNS
776

WP_007896501
706
DFEKLIDDAQKKAIKRES-LTEAVANLAGSPAIKKGILQSLKVVDEIVKVMG-HNPDNIVIEMSRENQ TTAQGLKNA
780

EFR44625
658
DFEKLIDDAQKKAiKRES-LTEAVANLAGSPAIKKGILQSLKVVDEIVKVMG-HNPDNIVIEMSRENQ TTAQGLKNA
732

WP_002897477
702
SFKEIIQKAQVVG-KTDD-VKQVVQELPGSPAIKKGILQSIKIVDELVKVMG-YALESIVIEMARENQ TTARGKKNS
775

WP_002906454
702
SFKEIIQKAQVVG-KTDD-VKQVVQEIPGSPAIKKGILQSIKIVDELVKVMG-HNPESIVIEMARENQ TTAKGKKNS
775

WP_009729476
703
SFKEIIQKAQVVG-KIND-VKQVVQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS
776

COR24647
706
SFKDEIANSQVIG-DGDD-LHQVVQELAGSPAIKKGILQSLKIVDELVKVMG-YNPEQIVVEMARENQ TTARGRNNS
779

WP_000066813
705
SFKEIIQKAQVFG-KTND-VKQVVQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS
778

WP_009754323
703
SFKEIIQKAQVVG-KTDD-LTQVVRELSGSPAIKKGILQSIKIVDELVKIMG-YAPESIVIEMARENQ TTAKGKKNS
776

WP_044674937
702
SFVDEIRLAQGSG-EAED-YRAEVONLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIVVEMARENQ FTNQGRRNS
775

WP_044676715
704
SFVDEIRLAQGSG-EAED-YRAEVONLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIVVEMARENQ FTNQGRRNS
777

WP_044680361
704
SFVDEIRLAQGSG-EAED-YRAEVONLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIVVEMARENQ FTNQGRRNS
777

WP_044681799
702
SFVDEIRLAQGSG-EAED-YRAEVONLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIVVEMARENQ FTNQGRRNS
775

WP_049533112
704
SFKEEIAKAQVIG-ETDD-LNQVVSDIAGSPAIKKGILQSLKIVDELVKVMG-YNPANIVIEMARENQ TTDKGRRNS
777

WP_029090905
683
LFKKIIEEQFENEtALLN--KORIDELAASPANKKGIWQAIKIVKELEKVLQ-QPAENIFIEFARSDE ES----KRS
752

WP_006506696
706
GYAQMIEEATSCPeDGKF-TYEEVERLAGSPALKRGIWQSLQIVEEITKVMK-CRPKYIYIEFERSEE -----KERT
776

AIT42264
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_034440723
711
SFKEKIRKAQDIN-QVND-IKEIVKDLPGSPAIKKGIYQSIRIVDEIIRKMK-DRPKNIVIEMARENQ TTQEGKNKS
784

AKQ21048
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

WP_004636532
707
SFKKKIEDAQTIE-DTTH-IYDTVAELPGSPAIKKGIRQALKIVEEIIDIIG-YEPENIVVEMARESQ TTKKGKDLS
780

WP_002364836
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_016631044
666
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
739

EMS75795
455
SFKEELANELALA-GNOS-LLEVVEALLGSPAIKKGIWOTLKIVEELIEIIG-YNPKNIVVEMARENQ RT----NRS
524

WP_002373311
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_002378009
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_002407324
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_002413717
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_010775580
717
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
790

WP_010818269
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_010824395
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_016622645
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_033624816
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_033625576
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_033789179
715
SFKNAIQKAQSSE-HEET-LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIVVEMARENQ TTSTGKRRS
788

WP_002310644
715
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
788

WP_002312694
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_002314015
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_002320716
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_002330729
715
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
788

WP_002335161
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_002345439
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_034867970
711
SFKEEIAKATVFS-KHKS-LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG-YKPKNIVIEMARENQ KT----HRT
780

WP_047937432
716
SFKKEIKKAQMIT-DTEN-LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG-YEPANIVVEMARENQ TTGRGLKSS
789

WP_010720994
711
SFKEEIAKATVFS-KHKS-LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG-YKPKNIVIEMARENQ KT----HRT
780

WP_010737004
711
SFKEEIAKATVFS-KHKS-LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG-YKPKNIVIEMARENQ KT----HRT
780

WP_034700478
711
SFKEEIAKATVFS-KHKS-LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG-YKPKNIVIEMARENQ KT----HRT
780

WP_007209003
708
SFKKIIEDSQPYK-EQQS-AEEIVSELSGSPAIKKGILQSLKIVDELVAIMG-YKPKNIVVEMARENQ TTGRGKONS
781

WP_023519017
705
SFKETIANELIMS-DSNV-LLDQVKAIPGSPAVKKGIWQSIKIVEEIIGIIG-KAPKNIVIEMARENQ RTSR----S
774

WP_010770040
708
SFKSEIAEAQSDM-NTED-LHEVVONLAGSPAIKKGILQSLKIVDELVDIMG-SLPKNIVVEMARENQ TTSRGRINS
781

WP_048604708
704
TFKEEIEKEQLKA-NSEESLIEIVONLAGSPAIKKGIFQSLKIVDELVEIMG-YAPTNIVVEMARENQ TTANGRRNS
778

WP_010750235
710
SFKEEIAKELTLS-DKQS-LLEVVEAIPGSPAIKKGIWQTLKIVEELIAIIG-YKPKNIVIEMARENQ TTTGGKNRS
783

AII16583
742
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGOKNS
816

WP_029073316
718
GFKKTIDDANSTSVSGKF-SYAEVQELAGSPAIKRGIWQALLIVDEIKKIMK-HEPAHVYIEFARNED -----KERK
788

WP_031589969
718
GFKKTIDDANSTSVSGKF-SYAEVQELAGSPAIKRGIWQALLIVDEIKKIMK-HEPAHVYIEFARNED -----KERK
788

KDA45870
699
SFKETIKNAQVIE-KEET-LAKTVQELPGSPAIKKGILQSLEIVDEIIKVMG-YKPKSIVVEMARETQ --THGTRKR
771

WP_039099354
713
DFDKLITEANQMM-LAENdVQDVINDLYTSPONKKALRQILLVVNDIQKAMKgQAPERILIEFAREDE VNPRLSVQR
788

AKP02966
707
DFKNYIENHNLNKNEDQN-ISNLVNDIHVSPALKRGITQSIKIVQEIVKFMG-HAPKYIFIEVTRETK TTSRGKRIQ
785

WP_010991369
707
SFKSIIEKEQVTT-ADKD-IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_033838504
707
SFKSIIEKEQVTT-ADKD-IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTGKGKNNS
780

EHN60060
710
SFKSIIEKEQVTT-ADKD-IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTGKGKNNS
783

EFR89594
476
SFKSIIEKEQVTT-ADKD-IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTGKGKNNS
549

WP_038409211
707
SFKSIIEKEQVST-ADKG-IQSIVAELAGSPAIKKGILQSLKIVDELVGIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

EFR95520
326
SFKSIIEKEQVST-ADKG-IQSIVAELAGSPAIKKGILQSLKIVDELVGIMG-YPPQTIVVEMARENQ TTGKGKNNS
399

WP_003723650
707
SFKSIIEKEQVST-TDKD-LQSIVAELAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_003727705
707
SFKSIIEKEQVST-TDKD-LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_003730785
707
SFKSIIEKEQVST-TDKD-LOSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_003733029
707
SFKSIIEKEQVST-TDKD-LOSIVAELAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTNKGKNNS
780

WP_003739838
707
SFKSIIEKEQVST-TDKD-LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTVKGKNNS
780

WP_014601172
707
SFKSIIEKEQVST-TDKD-LOSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_023548323
707
SFKSIIEKEQVST-ADKD-LOSIVADLAGSPAIKKGILQSLKVVEELVSVMG-YPPQTIVVEMARENQ TTNKGKNNS
780

WP_031665337
707
SFKSIIEKEQVST-TDKD-LQSIVAELAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

WP_031669209
707
SFKSIIEKEQVST-ADKD-LOSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIVVEMARENQ TTNKGKNNS
780

WP_033920898
707
SFKSIIEKEQVST-ADKD-LQSIVADLAGSPAIKKGILQSLKVVEELVSVMG-YPPQTIVVEMARENQ TTNKGKNNS
780

AKI42028
710
SFKSIIEKEQVST-TDKD-LOSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTGKGKNNS
783

AKI50529
710
SFKSIIEKEQVST-ADKD-LOSIVADLAGSPAIKKGILQSLKVVEELVSVMG-YPPQTIVVEMARENQ TTNKGKNNS
783

EFR83390
155
SFKSIIEKEQVST-TDKD-LOSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIVVEMARENQ TTVKGKNNS
228

WP_046323366
707
SFKSIIEKEQVST-ADKD-IQSIVADLAGSPAIKKGILQSLKIVDELVGIMG-YPPQTIVVEMARENQ TTGKGKNNS
780

AKE81011
719
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
793

CUO82355
710
GYAQMIEEASSCPKDGKF-TYEEVAKLAGSPALKRGIWQSLQIVEEITKVMK-CRPKYIYIEFERSEE -----KERT
780

WP_033162887
713
GYKQIIEESNMQDIEGPF-KYDEVKKLAGSPAIKRGIWQALLVVREITKFMK-HEPSHIYIEFAREEQ -----KVRK
783

AGZ01981
736
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
810

AKA60242
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTOKGQKNS
777

AKS40380
703
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
777

4UN5_B
707
TFKEDIQKAQVSG-QGDS-LHEHIANLAGSPAIKKGILQTVKVVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS
781

WP_010922251
778

embedded image

841

WP_039695303
781
QQRLKKLONSLK PSYI E----DK--VE---NSHLONDQLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
851

WP_045635197
776
QQRYKRIEDSLK ILAS NILKENP--TD---NNQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSYDIDHI
843

5AXW_A
488
KDAQKMINEMQK QTNE EIIRTTGk--E---NAKYLIEKIKLHDMQEGKCLYSLEAIplEd1LNNPFNYEVDHI
561

WP_009880683
462
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
525

WP_010922251
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLQNGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_011054416
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_011284745
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_011285506
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_011527619
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_012560673
778
RERMKRIEEGIK ELGS DILKEYP--VE---TTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_014407541
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_020905136
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_023080005
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_023610282
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLQNGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_030125963
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_030126706
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_031488318
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_032460140
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLQNGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_032461047
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_032462016
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_032462936
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLQNGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_032464890
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_033888930
603
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
666

WP_038431314
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_038432938
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_038434062
778
RERMKRIEEGIK ELGS DILKEYP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

BAQ51233
689
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
752

KGE60162
1
------------ ---- -------------------------------------QEL--D--INRLSGYDVDHI
16

KGE60856

------------ ---- ---------------------------------------------------------

WP_002989955
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_003030002
778
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
840

WP_003065552
781
QQRLKKLONSLK PSYI E----DK--VE---NSHLONDQLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
851

WP_001040076
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040078
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040080
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLQNGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040081
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040083
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040085
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALONERLFLYYLONGRDMYTGEAL--D--IDDLSQYDIDHI
846

WP_001040087
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040088
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040089
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040090
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040091
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040092
779
RQRYKLLEDGVK NLAS DILKEYP--TD---NQALONERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040094
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040095
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040096
776
RORLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040097
776
RORLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040098
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040099
776
RORLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040100
776
RORLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_001040104
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALONERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040105
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040106
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040107
779
RQRYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040108
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGETL--D--IDNLSQYDIDHI
846

WP_001040109
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_001040110
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_015058523
779
RQRYKLLEDGVK NLAS DILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_017643650
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLONGKDMYTDDEL--D--IDNLSQYDIDLI
846

WP_017647151
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALONERLFLYYLONGRDMYTGKAL--D--IDNLSQYDIDHI
846

WP_017648376
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLQNGRDMYTGKAL--D--IDNLSQYDIDHI
846

WP_017649527
779
RORYKLLDDGVK NLAS NILKEYP--TD---NQALONERLFLYYLQNGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_017771611
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALONERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_017771984
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

CFQ25032
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

CFV16040
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

KLJ37842
779
RORYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

KLJ72361
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

KLL20707
793
RORYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
860

KLL42645
779
RORYKLLEEGVK NLAS NILKEYP--TD---NQALONERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_047207273
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_047209694
776
RQRLTTLRESLA NLKS EKKPKYV--KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL--D--IDNLSQYDIDHI
846

WP_050198062
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_050201642
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_050204027
779
RQRYKLLEEGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_050881965
779
RORYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

WP_050886065
779
RORYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

AHN30376
779
RQRYKLLEDGVK NLAS DILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDSLSQYDIDHI
846

EAO78426
779
RQRYKLLDDGVK NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTGEAL--D--IDNLSQYDIDHI
846

CCW42055
779
RQRYKLLDDGVR NLAS NILKEYP--TD---NQALQNERLFLYYLONGRDMYTEKAL--D--IDNLSQYDIDHI
846

WP_003041502
778
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
840

WP_037593752
779
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
841

WP_049516684
779
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
841

GAD46167
778
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
840

WP_018363470
779
QQRLKKLQNSLK PSYI E----DK--VE---NSHLONDQLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
849

WP_003043819
787
RERKKRIEEGIK ELES QILKENP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
850

WP_006269658
778
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
840

WP_048800889
778
QQRLKLLQDSLT PVSI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGEEL--D--IHHLSDYDIDHI
840

WP_012767106
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_014612333
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_015017095
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_015057649
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_048327215
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_049519324
777
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
840

WP_012515931
777
RORMRKLEETAK KLGS NILKEHP--VD---NSQLQNDKRYLYYLONGKDMYTGDDL--D--IDYLSSYDIDHI
840

WP_021320964
777
RORMRKLEETAK KLGS NILKEHP--VD---NSQLQNDKRYLYYLONGKDMYTGDDL--D--IDYLSSYDIDHI
840

WP_037581760
777
RQRMRKLEETAK KLGS NILKEHP--VD---NSQLQNDKRYLYYLONGKDMYTGDDL--D--IDYLSSYDIDHI
840

WP_004232481
778
NORLKRLQDSLK PSYV D----SK--VE---NSHLONDRLFLYYIQNGKDMYTGEEL--D--IDHLSDYDIDHI
848

WP_009854540
779
QQRLKKLQSSLK PSYI E----DK--VE---NSHLONDQLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
849

WP_012962174
779
QQRLKKLQDSLK PSYI E----GK--VE---NNHLQDDRLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
849

WP_039695303
781
QQRLKKLQNSLK PSYI E----DK--VE---NSHLQNDQLFLYYIQNGKDMYTGDEL--D--IDHLSDYDIDHI
851

WP_014334983
778
NQRLKRLQDSLK PSYV D----SK--VE---NSHLQNDRLFLYYIQNGKDMYTGEEL--D--IDRLSDYDIDHI
848

WP_003099269
778
RQRLRKLEEVHK NTGS KILKEYN--VS---NTQLQSDRLYLYLLQDGKDMYTGKEL--D--YDNLSQYDIDHI
841

AHY15608
778
RQRLRKLEEVHK NTGS KILKEYN--VS---NTQLQSDRLYLYLLQDGKDMYTGKEL--D--YDNLSQYDIDHI
841

AHY17476
778
RQRLRKLEEVHK NTGS KILKEYN--VS---NTQLQSDRLYLYLLQDGKDMYTGKEL--D--YDNLSQYDIDHI
841

ESR09100

------------ ---- ---------------------------------------------------------

AGM98575
778
RORLRKLEEVHK NTGS KILKEYN--VS---NTQLQSDRLYLYLLQDGKDMYTGKEL--D--YDNLSQYDIDHI
841

ALF27331
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_018372492
791
AQRLKKIEDGIK -LGS DLLKONP--IQd--NKDLQKEKLFLYYMONGIDLYTGQPLncD--PDSLAFYDVDHI
857

WP_045618028
777
QQRYKRIEDALK NLAH NILKEHP--TD---NIQLQNDRLFLYYLONGKDMYTGKSL--D--INQLSSCDIDHI
844

WP_045635197
776
QQRYKRIEDSLK ILAS NILKENP--TD---NNQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSYDIDHI
843

WP_002263549
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002263887
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002264920
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002269043
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002269448
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002271977
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002272766
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002273241
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002275430
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002276448
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002277050
779
QQRYKRLKEAIK DLNH KILKEHP--TD---NQALONNRLFLYYLONGRDMYTGESL--D--INRLSDYDIDHV
846

WP_002277364
778
QQRLKGLTDSIK EFGS QILKEHP--VE---HSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002279025
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002279859
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002280230
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002281696
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002282247
779
QQRYKRLKEAIK DLNH KILKEHP--TD---NQALONNRLFLYYLONGRDMYTGESL--D--INRLSDYDIDHV
846

WP_002282906
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLQNGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002283846
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002287255
778
QQRLKGLTDSIK EFGS QILKEHP--VE---HSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002288990
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002289641
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLONDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002290427
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLONDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002295753
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002296423
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002304487
788
QKRYKRLEEAIK DINH KILKEHP--TD---NQALQNDRLFLYYLONGRDMYTEDPL--D--INRLSDYDIDHI
855

WP_002305844
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002307203
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002310390
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_002352408
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_012997688
778
QQRLKGLTDSIK EFGS QILKEHP--VK---HSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_014677909
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019312892
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019313659
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLQNGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019314093
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019315370
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019803776
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_019805234
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_024783594
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLONDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_024784288
779
QQRYKRLKEAIK DLNH KILKEHP--TD---NQALONNRLFLYYLONGRDMYTGESL--D--INRLSDYDIDHV
846

WP_024784666
778
QQRLKGLTDSIK EFGS QILKEHP--VE---HSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_024784894
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_024786433
779
QQRYKRLKEAIK DLNH KILKEHP--TD---NQALONNRLFLYYLONGRDMYTGESL--D--INRLSDYDIDHV
846

WP_049473442
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

WP_049474547
778
QQRLKGLTDSIK EFGS QILKEHP--VE---NSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
841

EMC03581
771
QQRLKGLTDSIK EFGS QILKEHP--VE---HSQLQNDRLFLYYLONGRDMYTGEEL--D--IDYLSQYDIDHI
834

WP_000428612
779
QQRYKRIEDSLK ILAS KILKEHP--TD---NIQLQNDRLFLYYLONGRDMYTGKPL--D--INQLSSYDIDHI
846

WP_000428613
777
QQRYKRIEDALK NLAS NILKEHP--TN---NIQLQNDRLFLYYLONGRDMYTGKPL--D--INQLSSYDIDHI
844

WP_049523028
776
QQRLKTLSDAIS ELG- NILKEHP--TD---NIQLQNDRLFLYYLQNGKDMYTGEAL--D--INQLSNYDIDHI
839

WP_003107102
747
RERLRKLEEVHK NIGS KILKEHE--IS---NAQLQSDRVYLYLLQDGKDMYTGKDL--D--FDRLSQYDIDHI
810

WP_054279288
779
RERMKRVQEVLK KLGS QLLKEHP--VE---NFQLQNERLYLYYLONGKDMYTGEEL--S--ISNLSHYDIDHI
842

WP_049531101
777
QQRYKRIEDSLK ILAS NILKEHP--TD---NIQLQNDRLFLYYLONGKDMYTGNPL--D--INHLSSYDIDHI
844

WP_049538452
777
QQRYKRIENSLK ILAS KILKEHP--TD---NNQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSCDIDHI
844

WP_049549711
777
QQRYKRIEDSLK ILAS NILKENP--TD---NNQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSYDIDHI
844

WP_007896501
781
RQRLKKIKEVHK KTGS RILEDNSerIT---NLTLQDNRLYLYLLQDGKDMYTGQDL--D--INNLSQYDIDHI
846

EFR44625
733
RQRLKKIKEVHK KTGS RILEDNSerIT---NLTLQDNRLYLYLLQDGKDMYTGQDL--D--INNLSQYDIDHI
798

WP_002897477
776
QQRYKRIEDALK NLAP NILKENP--TD---NIQLKNDRLFLYYLONGKDMYTGKPL--D--INQLSSYDIDHI
843

WP_002906454
776
QQRYKRIEDALK NLAP NILKENP--TD---NIQLQNDRLFLYYLONGKDMYTGKAI--D--INQLSNYDIDHI
843

WP_009729476
777
QQRYKRIEDSLK ILAS KILKEHP--TD---NIQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSCDIDHI
844

COR24647
780
QQRLGSLTKAIQ DFGS DILKRYP--VE---NNQLQNDQLYLYYLONGKDMYTGDTL--D--IHNLSQYDIDHI
843

WP_000066813
779
QQRYKRIEDSLK NLAS NILKENP--TD---NIQLQNDRLFLYYLONGRDMYTGKPL--E--INQLSNYDIDHI
846

WP_009754323
777
QQRYKRIEDALK NLAP TISKENP--TD---NIQLQNDRLFLYYLONGKDMYTGEAL--D--INQLSSYDIDHI
844

WP_044674937
776
QQRYKKIENAIK NLNS KILKEYP--TN---NQALQNDRLFLYYLONGKDMYTDEEL--D--IDQLSQYDIDHI
843

WP_044676715
778
QQRYKKIENAIK NLNS KILKEYP--TN---NQALQNDRLFLYYLONGKDMYTDEEL--D--IDQLSQYDIDHI
845

WP_044680361
778
QQRYKKIENAIK NLNS KILKEYP--TN---NQALQNDRLFLYYLONGKDMYTDEEL--D--IDOLSQYDIDHI
845

WP_044681799
776
QQRYKKIENAIK NLNS KILKEYP--TN---NQALQNDRLFLYYLONGKDMYTDEEL--D--IDOLSQYDIDHI
843

WP_049533112
778
QQRLKLLQDSLK PVNI K-----N--VE---NQQLQNDRLFLYYIQNGKDMYTGETL--D--INNLSQYDIDHI
840

WP_029090905
753
TPRDKFIEKAYA ETDT EHLKELK---Qr--SKQLSSQRLFLYFIQNGKCMYSGEHL--D--IERLDSYEVDHI
823

WP_006506696
777
ESKIKKLENVYK DEQT SVLEELKg-FDn--TKKISSDSLFLYFTQLGKCMYSGKKL--D--IDSLDKYQIDHI
849

AIT42264
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_034440723
785
KARLKKIQEGLE NLDS HVEKQAL---D---EEMLKSPKYYLYCLONGKDIYTGKDL--D--IGQLQTYDIDHI
848

AKQ21048
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

WP_004636532
781
KERLEKLTEAIK EFDG --VKVKD--LK---NENLRNDRLYLYYLONGRDMYTNEPL--D--INNLSKYDIDHI
845

WP_002364836
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_016631044
740
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
803

EMS75795
525
KPRLKALEEALK SFDS PLLKEQP--VD---NQALOKDRLYLYYLONGKDMYTGEAL--D--IDRLSEYDIDHI
588

WP_002373311
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_002378009
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_002407324
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMQNGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_002413717
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_010775580
791
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
854

WP_010818269
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_010824395
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_016622645
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_033624816
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_033625576
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_033789179
789
IQRLKIVEKAMA EIGS NLLKEQP--TT---NEQLRDTRLFLYYMONGKDMYTGDEL--S--LHRLSHYDIDHI
852

WP_002310644
789
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
852

WP_002312694
790
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_002314015
790
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_002320716
790
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_002330729
789
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
852

WP_002335161
790
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_002345439
790
RPRLKALEESLK DFGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_034867970
781
SPRLKALENGLK QIGS TLLKEQP--TD---NKALQKERLYLYYLONGRDMYTGEPL--E--IENLHQYEVDHI
844

WP_047937432
790
RPRLKALEESLK DEGS QLLKEYP--TD---NSSLOKDRLYLYYLONGRDMYTGAPL--D--IHRLSDYDIDHI
853

WP_010720994
781
KPRLKALENGLK QIGS TLLKEQP--TD---NKALQKERLYLYYLONGRDMYTGEPL--E--IENLHQYEVDHI
844

WP_010737004
781
SPRLKALENGLK QIGS TLLKEQP--TD---NKALQKERLYLYYLONGRDMYTGEPL--E--IENLHQYEVDHI
844

WP_034700478
781
KPRLKALENGLK QIGS TLLKEQP--TD---NKALQKERLYLYYLONGRDMYTGEPL--E--IENLHQYEVDHI
844

WP_007209003
782
KPRLKGIENGLK EFSD SVLKGSS--ID---NKQLQNDRLYLYYLQNGKDMYTGHEL--D--IDHLSTYDIDHI
845

WP_023519017
775
RPRLKALEEALK NIDS PLLKDYP--TD---NQALQKDRLYLYYLONGKDMYTGEPL--E--IHRLSEYDIDHI
838

WP_010770040
782
NPRMKALEEAMR NLRS NLLKEYP--TD---NQALQNDRLYLYYLONGKDMYTGLDL--S--LHNLSSYDIDHI
845

WP_048604708
779
RPRLKNLEKAID DLDS EILKKHP--VD---NKALQKDRLYLYYLONGKDMYTNEEL--D--IHKLSTYDIDHI
842

WP_010750235
784
KPRLKSLEEALK NEDS QLLKERP--VD---NQSLOKDRLYLYYLONGKDMYTGESL--D--IDRLSEYDIDHI
847

AII16583
817
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
880

WP_029073316
789
DSFVNQMLKLYK DFED EANKHLKg-EDa--KSKIRSERLKLYYTQMGKCMYTGKSL--D--IDRLDTYQVDHI
860

WP_031589969
789
DSFVNQMLKLYK DFED EANKHLKg-EDa--KSKIRSERLKLYYTQMGKCMYTGKSL--D--IDRLDTYQVDHI
860

KDA45870
772
EDRVQQIVKNLK ELPK ------P---S---NAELSDERKYLYCLONGRDMYTGAPL--D--YDHLQFYDVDHI
833

WP_039099354
789
KRQVEQVYQNIS EL-- EIRNELK---D1-SNSALSNTRLFLYFMQGGRDMYTGDSL--N--IDRLSTYDIDHI
856

AKP02966
786
RLQSKLLNKANG -LVP EELKKHKn--D------LSSERIMLYFLONGKSLYSEESL--N--INKLSDYQVDHI
858

WP_010991369
781
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELRNNRLYLYYLONGKDMYTGQDL--D--IHNLSNYDIDHI
844

WP_033838504
781
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELRNNRLYLYYLQNGKDMYTGQDL--D--IHNLSNYDIDHI
844

EHN60060
784
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELRNNRLYLYYLONGKDMYTGQDL--D--IHNLSNYDIDHI
847

EFR89594
550
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQDL--D--IHNLSNYDIDHI
613

WP_038409211
781
KPRFISLEKAIK EFGS QILKEHP--TD---NQCLKNDRLYLYYLONGKDMYTGKEL--D--IHNLSNYDIDHI
844

EFR95520
400
KPRFISLEKAIK EFGS QILKEHP--TD---NQCLKNDRLYLYYLONGKDMYTGKEL--D--IHNLSNYDIDHI
463

WP_003723650
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_003727705
781
KPRYKSLEKAIK DFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDIYTGQEL--D--IHNLSNYDIDHI
844

WP_003730785
781
KPRYKSLEKAIK DFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDIYTGQEL--D--IHNLSNYDIDHI
844

WP_003733029
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLQNGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_003739838
781
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELRNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_014601172
781
KPRYKSLEKAIK EFGS KILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_023548323
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_031665337
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_031669209
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

WP_033920898
781
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
844

AKI42028
784
KPRYKSLEKAIK EFGS KILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
847

AKI50529
784
KPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHI
847

EFR83390
229
RPRYKSLEKAIK EFGS QILKEHP--TD---NQELKNNRLYLYYLONGKDIYTGQEL--D--IHNLSNYDIDHI
292

WP_046323366
781
KPRFTSLEKAIK ELGS QILKEHP--TD---NQGLKNDRLYLYYLONGKDMYTGQEL--D--IHNLSNYDIDHV
844

AKE81011
794
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
857

CUO82355
781
ESKIKKLENVYK DEQT SVLEELKg-FDn--TKKISSDSLFLYFTQLGKCMYSGKKL--D--IDSLDKYQIDHI
853

WP_033162887
784
ESKIAKLQKIYE NLQT QVYESLKK-EDa--KKRMETDALYLYYLQMGKSMYSGKPL--D--IDKLSTYQIDHI
855

AGZ01981
811
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
874

AKA60242
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDAI
841

AKS40380
778
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDHI
841

4UN5_B
782
RERMKRIEEGIK ELGS QILKEHP--VE---NTQLQNEKLYLYYLONGRDMYVDQEL--D--INRLSDYDVDAI
845

WP_010922251
842

embedded image

910

WP_039695303
852
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LDIVRARKA-EWVRLYKSGLISKRKFDNLTKA--ERGGLTE
920

WP_045635197
844
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--IEVVQKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
912

5AXW_A
562
IPRSVSFDNSFNNKVLVKQEEASK-KGNR--TP Fqy-LSSSDSKI-SYETFKKHILNLAKGKGRISKTk-KEYLLEE
632

WP_009880683
526
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKQLLNAKLITORKFDNLTKA--ERGGLSE
594

WP_010922251
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_011054416
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_011284745
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSNN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_011285506
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_011527619
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_012560673
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKOLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_014407541
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
909

WP_020905136
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_023080005
841
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_023610282
841
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
909

WP_030125963
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_030126706
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_031488318
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKOLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_032460140
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKOLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_032461047
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKQLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_032462016
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_032462936
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKOLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_032464890
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_033888930
667
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITORKFDNLTKA--ERGGLSE
735

WP_038431314
842
VPQSFLKDDSIDNKVLIRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_038432938
841
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_038434062
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWKOLLNAKLITORKFDNLTKA--ERGGLSE
910

BAQ51233
753
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
821

KGE60162
17
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
85

KGE60856

--------------------------------- --------------------------------------------

WP_002989955
842
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_003030002
841
IPQAFIKDNSLDNRVLTRSDKNRG-KSDD--VP S--IEVVHEMKS-FWSKLLSVKLITQRKFDNLTKA--ERGGLTE
909

WP_003065552
852
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LDIVRARKA-EWVRLYKSGLISKRKFDNLTKA--ERGGLTE
920

WP_001040076
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040078
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040080
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040081
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040083
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040085
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040087
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040088
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040089
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040090
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040091
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040092
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--IDIVKARKA-FWKKLLDAKLISQRKYDNLTKA--ERGGLTP
915

WP_001040094
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040095
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040096
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040097
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040098
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040099
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSORKYDNLTKA--ERGGLTS
915

WP_001040100
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040104
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040105
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040106
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040107
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSORKYDNLTKA--ERGGLTS
915

WP_001040108
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_001040109
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSORKYDNLTKA--ERGGLTS
915

WP_001040110
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_015058523
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--IDIVKARKA-FWKKLLDAKLISQRKYDNLTKA--ERGGLTP
915

WP_017643650
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_017647151
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_017648376
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_017649527
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_017771611
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_017771984
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSORKYDNLTKA--ERGGLTS
915

CFQ25032
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

CFV16040
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

KLJ37842
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

KLJ72361
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

KLL20707
861
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
929

KLL42645
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_047207273
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_047209694
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--VEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_050198062
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_050201642
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_050204027
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDN--VP S--IDIVKARKA-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_050881965
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_050886065
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

AHN30376
847
VPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--IDIVKARKA-FWKKLLDAKLISQRKYDNLTKA--ERGGLTP
915

EAO78426
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

CCW42055
847
IPQAFIKDDSIDNRVLVSSAKNRG-KSDD--VP S--LEIVKDCKV-FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS
915

WP_003041502
841
IPQAYIKDDSFDNRVLTSSSENRG-KSDN--VP S--IEVVCARKA-DWMRLRKAGLISQRKFDNLTKA--ERGGLTE
909

WP_037593752
842
IPQAFIKDNSLDNRVLTRSDKNRG-KSDD--VP S--IEVVHEMKS-FWSKLLSVKLITQRKFDNLTKA--ERGGLTE
910

WP_049516684
842
IPQAFIKDNSLDNRVLTRSDKNRG-KSDD--VP S--IEVVHEMKS-FWSKLLSVKLITQRKFDNLTKA--ERGGLTE
910

GAD46167
841
IPQAFIKDNSLDNRVLTRSDKNRG-KSDD--VP S--IEVVHEMKS-FWSKLLSVKLITQRKFDNLTKA--ERGGLTE
909

WP_018363470
850
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LGIVRARKA-EWVRLYKSGLISKRKFDNLTKA--ERGGLTE
918

WP_003043819
851
VPQSFIKDDSIDNKVLTRSVENRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
919

WP_006269658
841
IPQAFIKDNSLDNRVLTRSDKNRG-KSDD--VP S--IEVVHEMKS-FWSKLLSVKLITORKFDNLTKA--ERGGLTE
909

WP_048800889
841
IPQAFIKDDSIDNRVLTSSAKNRG-KSDN--VP N--LEVVCDRKA-DWIRLREAGLISQRKFDNLTKA--ERGGLTE
909

WP_012767106
841
VPQSFIKDDSIDNKILTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_014612333
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
909

WP_015017095
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDD--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
909

WP_015057649
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_048327215
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDD--VP S--EEVVKKMKN-YWRQLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_049519324
841
VPQSFIKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
909

WP_012515931
841
IPQSFIKNNSIDNKVLTSQGANRG-KLDN--VP S--EAIVRKMKG-YWQSLLRAGAISKQKFDNLTKA--ERGGLTQ
909

WP_021320964
841
IPQSFIKNNSIDNKVLTSQGANRG-KLDN--VP S--EAIVRKMKG-YWQSLLRAGAISKQKFDNLTKA--ERGGLTQ
909

WP_037581760
841
IPQSFIKNNSIDNKVLTSQGANRG-KLDN--VP S--EAIVRKMKG-YWQSLLRAGAISKQKFDNLTKA--ERGGLTQ
909

WP_004232481
849
IPQAFIKDNSIDNRVLTSSAKNRG-KSDD--VP S--IEIVRNRKS-YWYKLYKSGLISKRKFDNLTKA--ERGGLTE
917

WP_009854540
850
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LDIVRARKA-EWVRLYKSGLISKRKFDNLTKA--ERGGLTE
918

WP_012962174
850
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LDIVHDRKA-DWIRLYKSGLISKRKFDNLTKA--ERGGLTE
918

WP_039695303
852
IPQAFIKDDSIDNRVLTSSAKNRG-KSDD--VP S--LDIVRARKA-EWVRLYKSGLISKRKFDNLTKA--ERGGLTE
920

WP_014334983
849
IPQAFIKDNSIDNKVLTSSAKNRG-KSDD--VP S--IEIVRNRRS-YWYKLYKSGLISKRKFDNLTKA--ERGGLTE
917

WP_003099269
842
IPQSFIKDNSIDNTVLTTQASNRG-KSDN--VP N--IETVNKMKS-FWYKQLKSGAISQRKFDHLTKA--ERGALSD
910

AHY15608
842
IPQSFIKDNSIDNTVLTTQASNRG-KSDN--VP N--IETVNKMKS-FWYKQLKSGAISQRKFDHLTKA--ERGALSD
910

AHY17476
842
IPQSFIKDNSIDNTVLTTQASNRG-KSDN--VP N--IETVNKMKS-FWYKQLKSGAISQRKFDHLTKA--ERGALSD
910

ESR09100

--------------------------------- --------------------------------------------

AGM98575
842
IPQSFIKDNSIDNTVLTTQASNRG-KSDN--VP N--IETVNKMKS-FWYKQLKSGAISQRKFDHLTKA--ERGALSD
910

ALF27331
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_018372492
858
VPRSYIKNDSFDNKVLTTSKGNRK-KLDD--VP A--KEVVEKMEN-TWRRLHAAGLISDIKLSYLMKGe-----LTE
923

WP_045618028
845
IPQAFIKDDSLDNRVLISSKDNRG-KSDN--VP S--LEIVOKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
913

WP_045635197
844
IPQAFIKDDSLDNRVLISSKDNRG-KSDN--VP S--IEVVQKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
912

WP_002263549
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002263887
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002264920
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKG--ERGGLTD
910

WP_002269043
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002269448
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--EDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002271977
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002272766
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKP-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002273241
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002275430
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKP-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002276448
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002277050
847
IPQAFIKDNSIDNRVLTSSKANRG-KSDD--VP S--EDVVNRMRP-FWNKLLSSGLISQRKYNNLTKK--E---LTP
912

WP_002277364
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002279025
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKP-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002279859
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKG--ERGGLTD
910

WP_002280230
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002281696
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002282247
847
IPQAFIKDNSIDNRVLTSSKANRG-KSDD--VP S--EDVVNRMRP-FWNKLLSSGLISQRKYNNLTKK--E---LTL
912

WP_002282906
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002283846
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002287255
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002288990
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002289641
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002290427
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKG--ERGGLTD
910

WP_002295753
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002296423
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_002304487
856
IPQAFIKDNSIDNRVLTRSDKNRG-KSDD--VP S--EEVVHKMKP-FWSKLLSAKLITORKFDNLTKA--ERGGLTD
924

WP_002305844
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002307203
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_002310390
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKG--ERGGLTD
910

WP_002352408
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_012997688
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_014677909
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_019312892
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_019313659
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_019314093
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_019315370
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKP-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_019803776
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_019805234
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKG--RGGLTD
910

WP_024783594
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_024784288
847
IPQAFIKDNSIDNRVLTSSKANRG-KSDD--VP S--EDVVNRMRP-FWNKLLSSGLISQRKYNNLIKK--E---LTL
912

WP_024784666
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_024784894
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITQRKFDNLTKA--ERGGLTD
910

WP_024786433
847
IPQAFIKDNSIDNRVLTSSKANRG-KSDD--VP S--EDVVNRMRP-FWNKLLSSGLISQRKYNNLTKK--E---LTL
912

WP_049473442
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKP-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

WP_049474547
842
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KDVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
910

EMC03581
835
IPQAFIKDNSIDNRVLTSSKENRG-KSDD--VP S--KNVVRKMKS-YWSKLLSAKLITORKFDNLTKA--ERGGLTD
903

WP_000428612
847
VPQAFIKDDSLDNRVLTSLKDNRG-KSDN--VP S--LEVVEKMKT-FWQQLLDSKLISYRKENNLTKA--ERGGLDE
915

WP_000428613
845
VPQAFIKDDSLDNRVLTSLKDNRG-KSDN--VP S--IEVVQKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
913

WP_049523028
840
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEIVEKMKG-FWQQLLDSKLISERKENNLTKA--ERGGLDE
908

WP_003107102
811
IPQSFIKDNSIDNIVLTSQESNRG-KSDN--VP Y--IAIVNKMKS-YWQHQLKSGAISQRKFDNLTKA--ERGGLSE
879

WP_054279288
843
IPRSFIKDDSIDNKVLTRSEHNRG-KTDN--VP S--IEVVKRMKP-YWQKLLDTKVISQRKFDNLTKA--ERGGLQE
911

WP_049531101
845
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEVVQKRKA-FWQQLLESKLISERKENNLTKA--ERGGLNE
913

WP_049538452
845
IPQAFIKDDSLDNRVLTSSKENRG-KSDN--VP C--LEVVDKMKV-FWQQLLDFKLISYRKENNLTKA--ERGGLDE
913

WP_049549711
845
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEVVOKRKA-FWQQLLDSKLISERKENNLTKAerERDGLNE
915

WP_007896501
847
IPQSFIKDNSIDNLVLTTQKANRG-KSDN--VP S--IEVVRDMKDrVWRRQLANGAISROKFDHLTKA--ERGGLAD
916

EFR44625
799
IPQSFIKDNSIDNLVLTTQKANRG-KSDN--VP S--IEVVRDMKDrVWRRQLANGAISRQKFDHLTKA--ERGGLAD
868

WP_002897477
844
IPQAFIKDDSIDNRVLTSSKDNRG-KSDN--VP S--LEVVOKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
912

WP_002906454
844
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--IEVVQKRKA-FWQQLLDSKLISERKENNLTKA--KRGGLDE
912

WP_009729476
845
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEVVDKMKV-FWQQLLDSKLISYRKENNLTKA--ERGGLNE
913

CQR24647
844
IPQSFIKDNSLDNRVLINSKSNRG-KSDN--VP S--NEVVKRMKG-FWLKOLDAKLISQRKFDNLTKA--ERGGLSA
912

WP_000066813
847
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEVVEKMKA-FWQQLLDSKLISERKENNLTKAerERGGLNE
917

WP_009754323
845
IPQAFIKDDSLDNRVLTSSKDNRG-KSDN--VP S--LEVVKKRKA-FWQQLLDSKLISERKENNLTKA--ERGGLDE
913

WP_044674937
844
IPQAFIKDDSLDNKVLTKSAKNRG-KSDD--VP S--LEIVHKKKN-FWKOLLDSQLISQRKFDNLTKA--ERGGLTN
912

WP_044676715
846
IPQAFIKDDSLDNKVLTKSAKNRG-KSDD--VP S--LEIVHKKKN-FWKOLLDSQLISQRKFDNLTKA--ERGGLIN
914

WP_044680361
846
IPQAFIKDDSLDNKVLTKSAKNRG-KSDD--VP S--LEIVHKKKN-FWKQLLDSQLISQRKFDNLTKA--ERGGLIN
914

WP_044681799
844
IPQAFIKDDSLDNKVLTKSAKNRG-KSDD--VP S--LEIVHKKKN-FWKQLLDSQLISQRKFDNLTKA--ERGGLIN
912

WP_049533112
841
IPQAFIKDDSFDNRVLTSSSENRG-KSDN--VP S--IEVVRARKA-DWMRLRKAGLISQRKFDNLTKA--ERGGLTE
909

WP_029090905
824
LPQSYIKDNSIENLALVKKVENQR-KKDS11LN S---SIINQNYS-RWEQLKNAGLIGEKKERNLTRTK-----ITD
890

WP_006506696
850
VPQSLVKDDSFDNRVLVVPSENQR-KLDD1vVP ---FDIRDKMYR-FWKLLFDHELISPKKFYSLIKTe-----YTE
916

AIT42264
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITQRKFDNLTKA--ERGGLSE
910

WP_034440723
849
IPRSFITDNSFDNLVLTSSTVNRG-KLDN--VP Sp--DIVRQQKG-FWKOLLRAGLMSQRKENNLTKGK-----LTD
914

AKQ21048
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
910

WP_004636532
846
IPQSFTTDNSIDNKVLVSRTKNQGnKSDD--VP S--INIVHKMKP-FWRQLHKAGLISDRKFKNLTKA--EHGGLTE
915

WP_002364836
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_016631044
804
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
872

EMS75795
589
IPRSFIVDNSIDNKVLVSSKENRL-KMDD--VP D--QKVVIRMRR-YWEKLLRANLISERKFAYLTKLe-----LTP
654

WP_002373311
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KKVVKKMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_002378009
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_002407324
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_002413717
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_010775580
855
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKKMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
923

WP_010818269
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFQRLTKG--EQGGLTL
921

WP_010824395
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_016622645
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKDMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_033624816
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKKMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_033625576
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKKMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_033789179
853
IPQSFMKDDSLDNLVLVGSTENRG-KSDD--VP S--KEVVKKMKA-YWEKLYAAGLISQRKFORLTKG--EQGGLTL
921

WP_002310644
853
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
918

WP_002310644
853
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
918

WP_002312694
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_002314015
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_002320716
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_002330729
853
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
918

WP_002335161
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_002345439
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_034867970
845
IPRSFIVDNSIDNKVLVASKQNQK-KRDD--VP K--KQIVNEQRI-FWNOLKEAKLISTKKYAYLTKIe-----LTP
910

WP_047937432
854
IPRSFTTDNSIDNKVLVSSKENRL-KKDD--VP S--EKVVKKMRS-FWYDLYSSKLISKRKLDNLTKIk-----LTE
919

WP_010720994
845
IPRSFIVDNSIDNKVLVASKQNQK-KKDD--VP K--KQIVNEQRI-FWNOLKEAKLISPKKYAYLTKIe-----LTP
910

WP_010737004
845
IPRSFIVDNSIDNKVLVSSKENRL-KKDD--VP K--KQIVNEQRI-FWNQLKEAKLISPKKYAYLTKIe-----LTP
910

WP_034700478
845
IPRSFIVDNSIDNKVLVSSKENRL-KKDD--VP N--KQIVNEQRI-FWNQLKEAKLISPKKYAYLTKIe-----LTP
910

WP_007209003
846
IPQSFLTDNSIDNRVLTTSKSNRG-KSDN--VP S--EEVVRKMDR-FWRKLLNAKLISERKYTNLTKKe-----LTE
911

WP_023519017
839
IPRSFIVDNSLDNKVLVSSKVNRG-KLDN--AP D--PLVVKRMRS-HWEKLHQAKLISDKKLANLTKQn-----LTE
904

WP_010770040
846
VPQSFTTDNSLDNRVLVSSKENRG-KKDD--VP S--KEVVQKNIT-LWETLKNSNLISQKKYDNLTKG--LRGGLTE
914

WP_048604708
843
IPQSFIVDNSLDNRVLVSSSKNRG-KLDD--VP S--KEVVKKMRA-FWESLYRSGLISKKKFDNLVKA--ESGGLSE
911

WP_010750235
848
IPRSFIVDHSLDNKVLVSSKENRL-KKDD--VP D--SKVVKRMKA-YWEKLLRANLISERKFSYLTKLe-----LTD
913

AII16583
881
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITQRKEDNLTKA--ERGGLSE
949

WP_029073316
861
VPQSLLKDDSIDNKVLVLSSENQR-KLDDlvlP ---EMIRNKMFG-FWNKLYENKIISPKKFYSLIKSe-----YSD
927

WP_031589969
861
VPQSLLKDDSIDNKVLVLSSENQR-KLDDlvlP ---SSIRNKMYG-FWEKLENNKIISPKKFYSLIKTe-----FNE
927

KDA45870
834
IPQSFLKDDSIENKVLTIKKENVR-KTNG--LP S--EAVIQKMGS-FWKKLLDAGAMTNKKYDNLRRN1--HGGLNE
902

WP_039099354
857
LPQSFIKDNSLDNRVLVSQRMNRS-KADQ--VP S--VELGQKMQI-QWEQMLRAGLITKKKYDNLTLNp--------
923

AKP02966
859
LPRTYIPDDSLENKALVLAKENQR-KADDllLN S---NVIDKNLE-RWTYMLNNNMMGLKKFKNLTRRv-----ITD
925

WP_010991369
845
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_033838504
845
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

EHN60060
848
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
916

EFR89594
614
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVQKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
682

WP_038409211
845
IPQSFITDNSIDNRVLTSSTANRE-KGDN--VP L--LEVVRKRKA-FWEKLYQAKLMSKRKFDYLTKA--ERGGLTE
913

EFR95520
464
IPQSFITDNSIDNRVLTSSTANRE-KGDN--VP L--LEVVRKRKA-FWEKLYQAKLMSKRKEDYLTKA--ERGGLTE
532

WP_003723650
845
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_003727705
845
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_003730785
845
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_003733029
845
VPQSFITDNSVDNLVLTSSAGNRE-KGGN--VP P--LEIVQKRKI-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_003739838
845
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVRKRKV-FWEKLFQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_014601172
845
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTD
913

WP_023548323
845
VPQSFITDNSIDNLVLTSSAGNRE-KGDN--VP P--LEIVQKRKI-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_031665337
845
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_031669209
845
VPQSFITDNSVDNLVLTSSAGNRE-KGDN--VP P--LEIVOKRKI-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
913

WP_033920898
845
VPQSFITDNSIDNLVLTSSAGNRE-KGDN--VP P--LEIVOKRKI-FWEKLYQGNLMSKRKEDYLTKA--ERGGLTE
913

AKI42028
848
VPQSFITDNSIDNLVLTSSAGNRE-KGGD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTD
916

AKI50529
848
VPQSFITDNSIDNLVLTSSAGNRE-KGDN--VP P--LEIVQKRKI-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
916

EFR83390
293
VPQSFITDNSIDNLVLTSSAGNRE-KGDD--VP P--LEIVRKRKV-FWEKLYQGNLMSKRKFDYLTKA--ERGGLTE
361

WP_046323366
845
VPQSFITDNSIDNRVLASSAANRE-KGDN--VP S--LEVVRKRKV-YWEKLYQAKLMSKRKEDYLTKA--ERGGLTE
913

AKE81011
858
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
926

CUO82355
854
VPQSLVKDDSFDNRVLVLPSENQR-KLDD1vVP ---FDIRDKMYR-FWKLLFDHELISPKKFYSLIKTe-----YTE
920

WP_033162887
856
LPQSLIKDDSFDNRVLVLPEENQW-KLDSetVP ---FEIRNKMIG-FWQMLHENGLMSNKKFFSLIRTd-----FSD
922

AGZ01981
875
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
943

AKA60242
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITORKFDNLTKA--ERGGLSE
910

AKS40380
842
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWRQLLNAKLITQRKFDNLTKA--ERGGLSE
910

4UN5_B
846
VPQSFLKDDSIDNKVLTRSDKNRG-KSDN--VP S--EEVVKKMKN-YWROLLNAKLITORKFDNLTKA--ERGGLSE
914

WP_010922251
911

embedded image

981

WP_039695303
921
AD KAGFIKRQLVETROITKHVAQILDARFNTEHDENDKVIR--DVKVITLKSNLVSQFRKDF EFYKVREINDY
991

WP_045635197
913
RD KVGFIKRQLVETRQITKHVAQILDARYNTEVNEKDKKNR--TVKIITLKSNLVSNFRKEF RLYKVREINDY
983

5AXW_A
633
RD QKDFINRNLVDTRYATRGLMNLLRSYFR---------VNn1DVKVKSINGGFTSFLRRKW KFKKERNKGYK
702

WP_009880683
595
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
665

WP_010922251
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_011054416
911
LD KVGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_011284745
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_011285506
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_011527619
911
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_012560673
911
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_014407541
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_020905136
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_023080005
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_023610282
910
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_030125963
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_030126706
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_031488318
911
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

WP_032460140
911
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_032461047
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_032462016
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

WP_032462936
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDERKDE QFYKVREINNY
981

WP_032464890
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_033888930
736
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
806

WP_038431314
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

WP_038432938
910
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_038434062
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

BAQ51233
822
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
892

KGE60162
86
LD KVGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVRVITLKSKLVSDFRKDF QFYKVREINNY
156

KGE60856

-- ------------------------------------------------------------ -----------

WP_002989955
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

WP_003030002
910
ED KAGFIKRQLVETRQITKHVAQILDERENTEFDGNKRRIR--NVKIITLKSNLVSNERKEF ELYKVREINDY
980

WP_003065552
921
AD KAGFIKRQLVETROITKHVAQILDARFNTESDENDKVIR--DVKVITLKSNLVSQFRKDF EFYKVREINDY
991

WP_001040076
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF VFYKIREVNNY
986

WP_001040078
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_001040080
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040081
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040083
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040085
916
DD KARFIQROLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040087
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040088
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_001040089
916
DD KARFIQROLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040090
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_001040091
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040092
916
DD KAGFIQRQLVETROITKHVARILDERFNNKVDDNNKPIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_001040094
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040095
916
DD KARFIQROLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040096
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040097
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040098
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040099
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040100
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040104
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_001040105
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_001040106
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNDY
986

WP_001040107
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNDY
986

WP_001040108
916
DD KARFIQROLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_001040109
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_001040110
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_015058523
916
DD KAGFIQRQLVETROITKHVARILDERFNNKVDDNNKPIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_017643650
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_017647151
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_017648376
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_017649527
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_017771611
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_017771984
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

CFQ25032
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

CFV16040
916
DD KARFIQRQLVEIRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

KLJ37842
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTVKSNLVSNERKEF GFYKIREVNNY
986

KLJ72361
916
DD KARFIQRQLVETRQITKHVARILDELFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

KLL20707
930
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
1000

KLL42645
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_047207273
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_047209694
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_050198062
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

WP_050201642
916
DD KARFIQROLVETROITKHVASILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

WP_050204027
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNDY
986

WP_050881965
916
DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVILKSNLVSNERKEF GFYKIREVNNY
986

WP_050886065
916
DD KARFIQROLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

AHN30376
916
DD KAGFIQRQLVETROITKHVARILDERFNNKVDDNNKPIR--KVKIVTLKSNLVSNERKEF GFYKIREVNNY
986

EAO78426
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY
986

CCW42055
916
DD KARFIQRQLVETROITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNDY
986

WP_003041502
910
ND KAGFIKRQLVETROITKHVAQVLDARFNAKHDENKKVIR--DVKIITLKSNLVSQFRKDF KFYKVREINDY
980

WP_037593752
911
ED KAGFIKRQLVETRQITKHVAQILDERENTEFDGAQRRIR--NVKIITLKSNLVSNERKEF ELYKVREINDY
981

WP_049516684
911
ED KAGFIKRQLVETRQITKHVAQILDERENTEFDGAQRRIR--NVKIITLKSNLVSNERKEF ELYKVREINDY
981

GAD46167
910
ED KAGFIKRQLVETRQITKHVAQILDERENTEFDGAQRRIR--NVKIITLKSNLVSNFRKEF ELYKVREINDY
980

WP_018363470
919
AD KAGFIKRQLVETROITKHVAQILDARFNTERDENDKVIR--DVKVITLKSNLVSQFRKEF KFYKVREINDY
989

WP_003043819
920
AD KAGFIKRQLVETROITKHVARILDSRMNTKRDKNDKPIR--EVKVITLKSKLVSDFRKDF QLYKVRDINNY
990

WP_006269658
910
ED KAGFIKRQLVETROITKHVAQILDERFNTEFDGNKRRIR--NVKIITLKSNLVSNFRKEF ELYKVREINDY
980

WP_048800889
910
ND KAGFIHRQLVETROITKHVAQILDARFNPKRDDNKKVIR--DVKIITLKSNLVSQFRRDF KLYKVREINDY
980

WP_012767106
910
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_014612333
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
980

WP_015017095
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDE QFYKVREINNY
980

WP_015057649
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_048327215
910
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_049519324
910
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
980

WP_012515931
910
VD KAGFIQROLVETROITKHVAQILDSRENTEFDDHNKRIR--KVHIITLKSKLVSDFRKEF GLYKIRDINHY
980

WP_021320964
910
VD KAGFIQROLVETROITKHVAQILDSRENTEFDDHNKRIR--KVHIITLKSKLVSDFRKEF GLYKIRDINHY
980

WP_037581760
910
VD KAGFIQLOLVETROITKHVAQILDSRENTEFDDHNKRIR--KVHIITLKSKLVSDFRKEF GLYKIRDINHY
980

WP_004232481
918
TD KAGFIKRQLVETROITKHVAQILDARFNTKCDENDKVIR--DVKVITLKSSLVSQFRKEF KFYKVREINDY
988

WP_009854540
919
AD KAGFIKRQLVETROITKHVAQILDARFNTEHDENDKVIR--DVKVITLKSNLVSQFRKDF EFYKVREINDY
989

WP_012962174
919
ND KAGFIKRQLVETROITKHVAQILDSRENTERDENDKVIR--NVKVITLKSNLVSQFRKDF KFYKVREINDY
989

WP_039695303
921
AD KAGFIKRQLVETROITKHVAQILDARFNTEHDENDKVIR--DVKVITLKSNLVSQFRKDF EFYKVREINDY
991

WP_014334983
918
AD KAGFIKRQLVETROITKHVAQILDARFNTKRDENDKVIR--DVKVITLKSNLVSQFRKEF KFYKVREINDY
988

WP_003099269
911
FD KAGFIKRQLVETROITKHVAQILDSRFNSNLTEDSKSNR--NVKIITLKSKMVSDERKDF GFYKLREVNDY
981

AHY15608
911
FD KAGFIKRQLVETROITKHVAQILDSRENSNLTEDSKSNR--NVKIITLKSKMVSDERKDF GFYKLREVNDY
981

AHY17476
911
FD KAGFIKRQLVETROITKHVAQILDSRENSNLTEDSKSNR--NVKIITLKSKMVSDERKDF GFYKLREVNDY
981

ESR09100

-- ------------------------------------------------------------ -----------

AGM98575
911
FD KAGFIKRQLVETROITKHVAQILDSRENSNLTEDSKSNR--NVKIITLKSKMVSDERKDF GFYKLREVNDY
981

ALF27331
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_018372492
924
ED KAGFIRRQLVETROITKHVARLLDEKLNRKKNENGEKLR--TTKIITLKSVFASRFRANF DLYKLRELNHY
994

WP_045618028
914
RD KVGFIKRQLVETRQITKHVAQILDARFNTEVTEKDKKDR--SVKIITLKSNLVSNFRKEF RLYKVREINDY
984

WP_045635197
913
RD KVGFIKRQLVETROITKHVAQILDARYNTEVNEKDKKNR--TVKIITLKSNLVSNERKEF RLYKVREINDY
983

WP_002263549
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002263887
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002264920
911
DD KAGFIKRQLVETRQITKHVARILDERENTETDENNKKIR--QVKIVILKSNLVSNERKEF ELYKVREINDY
981

WP_002269043
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVILKSNLVSNFRKEF ELYKVREINDY
981

WP_002269448
911
DD KAGFIKRQLVETROITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002271977
911
DD KAGFIKRQLVETROITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002272766
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002273241
911
DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVILKSNLVSNERKEF ELYKVREINDY
981

WP_002275430
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002276448
911
DD KAGFIKROLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002277050
913
DD KAGFIKRQLVETROITKHVARMLDERENKEFDDNNKRIR--RVKIVTLKSNLVSSFRKEF ELYKVREINDY
983

WP_002277364
911
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002279025
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002279859
911
DD KAGFIKRQLVETRQITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002280230
911
DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002281696
911
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002282247
913
DD KAGFIKRQLVETROITKHVARMLDERENKEFDDNNKRIR--RVKIVTLKSNLVSSFRKEF ELYKVREINDY
983

WP_002282906
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVILKSNLVSNERKEF ELYKVREINDY
981

WP_002283846
911
DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002287255
911
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002288990
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVILKSNLVSNFRKEF ELYKVREINDY
981

WP_002289641
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002290427
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002295753
911
DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002296423
911
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002304487
925
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
995

WP_002305844
911
DD KAGFIKRQLVETROITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002307203
911
DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_002310390
911
DD KAGFIKHQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_002352408
911
DD KAGFIKRQLVETROITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_012997688
911
DD KAGFIKROLVETRQITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_014677909
911
DD KAGFIKROLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_019312892
911
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_019313659
911
DD KAGFIKROLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_019314093
911
DD KAGFIKRQLVETRQITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_019315370
911
DD KAGFIKRQLVETROITKHVARILDERFNTETDENNKKIR--QVKIVILKSNLVSNFRKEF ELYKVREINDY
981

WP_019803776
911
DD KAGFIKRQLVETROITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_019805234
911
DD KAGFIKROLVETRQITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_024783594
911
DD KAGFIKRQLVETROITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
981

WP_024784288
913
DD KAGFIKRQLVETRQITKHVARMLDERFNKEFDDNNKRIR--RVKIVTLKSNLVSSFRKEF ELYKVREINDY
983

WP_024784666
911
DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_024784894
911
DD KAGFIKROLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_024786433
913
DD KAGFIKRQLVETROITKHVARMLDERFNKEFDDNNKRIR--RVKIVTLKSNLVSSFRKEF ELYKVREINDY
983

WP_049473442
911
DD KAGFIKRQLVETROITKHVARILDERENTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

WP_049474547
911
DD KAGFIKROLVETRQITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNERKEF ELYKVREINDY
981

EMC03581
904
DD KAGFIKRQLVETROITKHVARILDERFHTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY
974

WP_000428612
916
RD KVGFIKRQLVETRQITKHVAQILDARYNTEVNEKDKKNR--TVKIITLKSNLVSNERKEF RLYKIREINDY
986

WP_000428613
914
RD KVGFIKRQLVETRQITKHVAQILDARFNKEVNEKDKKNR--TVKIITLKSNLVSNFRKEF RLYKVREINDY
984

WP_049523028
909
RD KVGFIKRQLVETROITKHVAQILDDRFNAEVNEKNQKLR--SVKIITLKSNLVSNFRKEF GLYKVREINDY
979

WP_003107102
880
YD KAGFIKRQLVETROITKHVAQILNNRENNNVDDSSKNKR--PVKIITLKSKMVSDFRKEF GFYKIREVNDY
950

WP_054279288
912
SD KANFIQROLVETROITKHVAQILDSRENTERDEKDRPIR--RVKVITLKSKFVSDFRQDE GFYKLREINDY
982

WP_049531101
914
RD KVGFIKRQLVETRQITKHVAQILDSRFNTKVNEKNQKIR--TVKIITLKSNLVSNFRKEF RLYKVREINDY
984

WP_049538452
914
RD KVGFIRROLVETRQITKHVAQILDSRFNTEVTEKDKKNR--NVKIITLKSNLVSNFRKEF GLYKVREINDY
984

WP_049549711
916
LD KVGFIKRQLVETROITKHVAQILDARFNKEVTEKDKKNR--NVKIITLKSNLVSNFRKEF RLYKVREINDY
986

WP_007896501
917
SD KARFLRRQLVETROITKHVAQLLDSRENSKSNONKKLAR--NVKIITLKSKIVSDFRKDF GLYKLREVNNY
987

EFR44625
869
SD KARFLRROLVETROITKHVAQLLDSRENSKSNONKKLAR--NVKIITLKSKIVSDFRKDF GLYKLREVNNY
939

WP_002897477
913
RD KVGFIRROLVETQQITKNVAQILDARFNTEVKEKNQKIR--TVKIITLKSNLVSNERKEF GLYKVREINNY
983

WP_002906454
913
RD KVGFIKRQLVETRQITKHVAQLLDTRENTEVNEENQKIR--TVKIITLKSNLVSNERKEF GLYKVREINDY
983

WP_009729476
914
LD KVGFIKRQLVETRQITKHVAQILDARFNKEVTEKDKKNR--TVKIITLKSNLVSNFRKEF ELYKVREINDY
984

CQR24647
913
ED KAGFIKRQLVETROITKHVARILDERFNRDEDKNDKRIR--NVKIVTLKSNLVSNERKEF GFYKVREINNF
983

WP_000066813
918
LD KVGFIKRQLVETRQITKHVAQFLDARFNKEVTEKDKKNR--NVKIITLKSNLVSNFRKEF GLYKVREINDY
988

WP_009754323
914
RD KVGFIKRQLVETRQITKHVARILDARFNTEVSEKNQKIR--SVKIITLKSNLVSNERKEF KLYKVREINDY
984

WP_044674937
913
ED KARFIQRQLVETROITKHVARILDTRENTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY
985

WP_044676715
915
ED KARFIQRQLVETROITKHVARILDTRENTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY
987

WP_044680361
915
ED KARFIQRQLVETROITKHVARILDTRENTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY
987

WP_044681799
913
ED KARFIQRQLVETROITKHVARILDTRENTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY
985

WP_049533112
910
ND KAGFIKRQLVETRQITKHVAQVLDARFNAKHDENKKVIR--DVKIITLKSNLVSQFRKDF KFYKVREINDY
980

WP_029090905
891
RD KEGFIARQLVETRQITKHVTQLLQQEY-----------K-dTTKVFAIKATLVSGLRRKF EFIKNRNVNDY
951

WP_006506696
917
RD EERFINROLVETRQITKNVTQIIEDHYST-------------TKVAAIRANLSHEFRVKN HIYKNRDINDY
976

AIT42264
911
LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_034440723
915
RD ROOFINROLVETROITKHVANLLSHHLNEK-----KEVG--EINIVLLKSALTSQFRKKE DFYKVREVNDY
980

AKQ21048
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
981

WP_004636532
916
AD RAHFLNRQLVETROITKHVANLLDSQYNTAEEQ-----R---INIVLLKSSMTSRFRKEF KLYKVREINDY
980

WP_002364836
922
ED KAHFIQROLVETROITKNVAGILDQRYNANSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_016631044
873
ED KAHFIQRQLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
938

EMS75795
655
ED KARFIQROLVETRQITKHVAAILDQYFN-QPEE-SK-NK--GIRIITLKSSLVSQFRKTF GINKVREINNH
722

WP_002373311
922
ED KAHFIQROLVETRQITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_002378009
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_002407324
922
ED KAHFIQROLVETRQITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_002413717
922
ED KAHFIQRQLVETROITKNVAGILNQRYNANSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_010775580
924
ED KAHFIQROLVETROITKNVAGILDORYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
989

WP_010818269
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_010824395
922
ED KAHFIQROLVETROITKNVAGILDQLYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_016622645
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_033624816
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_033625576
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_033789179
922
ED KAHFIQROLVETROITKNVAGILDQRYNAKSKE-----K--KVQIITLKASLTSQFRSIF GLYKVREVNDY
987

WP_002310644
919
ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
988

WP_002312694
920
ED KAGFIKRQLVETRQITKHVAGILHHREN-KAEDTNDPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_002314015
920
ED KAGFIKRQLVETROITKHVAGILHHRFN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_002320716
920
ED KAGFIKRQLVETROITKHVAGILHHREN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_002330729
919
ED KAGFIKRQLVETROITKHVAGILHHREN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
988

WP_002335161
920
ED KAGFIKRQLVETROITKHVAGILHHREN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_002345439
920
ED KAGFIKRQLVETRQITKHVAGILHHREN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_034867970
911
ED KARFIQRQLVETROITKHVANILHQSFN-QEEEGTD-CD--GVQIITLKATLTSQFRQTF GLYKVREINPH
979

WP_047937432
920
ED KAGFIKRQLVETROITKHVAGILHHREN-KAEDTNEPIR--KVRIITLKSALVSQFRNRF GIYKVREINEY
989

WP_010720994
911
ED KARFIQROLVETROITKHVANILHOSFN-QEEEGTD-CD--GVQIITLKATLTSQFRQTF GLYKVREINPH
979

WP_010737004
911
ED KARFIQRQLVETROITKHVANILHQSFN-QEEEGTD-CD--GVQIITLKATLTSQFROTF GLYKVREINPH
979

WP_034700478
911
ED KARFIQRQLVETROITKHVANILHQSFN-QEEEGTD-CD--GVQIITLKATLTSQFRQTF GLYKVREINPH
979

WP_007209003
912
SD KAGFLKRQLVETRQITKHVATILDSKFNE--DSNNRDVQ-----IITLKSALVSEFRKTF NLYKVREINDL
977

WP_023519017
905
AD KARFIQRQLVETRQITKHVANLLHQHFN-LPEEVSA-TE--KTSIITLKSTLTSQFROMF DIYKVREINHH
973

WP_010770040
915
DD RAHFIKRQLVETROITKHVARILDORFNSQKDEEGKTIR--AVRVVTLKSSLTSQFRKQF AIHKVREINDY
985

WP_048604708
912
DD KAGFIHRQLVETROITKNVARILHQRFNSEKDEEGNLIR--KVRIITLKSALTSQFRKNY GIYKIREINDY
982

WP_010750235
914
DD KARFIQROLVETRQITKHVAAILHQYFN-QTQELEK-EK--DIRIITLKSSLVSQFRQVF GIHKVREINHH
982

AII16583
950
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
1020

WP_029073316
928
KD KERFINRQIVETROITKHVAQIISNHYET-------------TKVVTVRADLSHAFRERY HIYKNRDINDF
987

WP_031589969
928
KD QERFINROIVETRQITKHVAQIIDNHYEN-------------TKVVTVRADLSHQFRERY HIYKNRDINDF
987

KDA45870
903
KL KERFIERQLVETRQITKYVAQLLDORLN--YDGNGVELD-eKIAIVILKAQLASQFRSEF KLRKVRALNNL
972

WP_039099354
924
-D MKGFINROLVETROVIKLATNLLMEQYGED-----------NIELITVKSGLTHQMRTEF DFPKNRNLNNH
990

AKP02966
926
KD KLGFIHRQLVQTSQMVKGVANILNSMYK---NQGTTCIQ--------ARANLSTAFRKAL ELVKNRNINDF
999

WP_010991369
914
AD KARFIHRQLVETRQITKNVANILHQRFNYEKDDHGNTMK--QVRIVTLKSALVSQFRKOF QLYKVRDVNDY
984

WP_033838504
914
AD KARFIHRQLVETROITKNVANILHQRFNYEKDDHGNTMK--QVRIVTLKSALVSQFRKOF QLYKVRDVNDY
984

EHN60060
917
AD KARFIHRQLVETROITKNVANILHQRFNYEKDDHGNTMK--QVRIVTLKSALVSQFRKOF QLYKVRDVNDY
987

EFR89594
683
AD KARFIHRQLVETRQITKNVANILHQRFNYGKDDHGNTMK--QVRIVTLKSALVSQFRKOF QLYKVRGVNDY
753

WP_038409211
914
AD KANFIQRQLVETROITKNVANILYQRFNCKQDENGNEVE--QVRIVTLKSTLVSQFRKOF QLYKVREVNDY
984

EFR95520
533
AD KANFIQRQLVETROITKNVANILYQRFNCKQDENGNEVE--QVRIVTLKSTLVSQFRKOF QLYKVREVNDY
603

WP_003723650
914
AD KARFIHRQLVETRQITKNVANILYQRFNKETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNGY
984

WP_003727705
914
AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNDY
984

WP_003730785
914
AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNDY
984

WP_003733029
914
AD KARFIHRQLVETRQITKNVANILHQRFNYKTDGNKDTME--TVRIVTLKSALVSQFRKOF QFYKVREVNDY
984

WP_003739838
914
AD KATFIHRQLVETROITKNVANILHQRFNNETDNHGNNME--QVRIVMLKSALVSQFRKOF QLYKVREVNDY
984

WP_014601172
914
AD KARFIHRQLVETRQITKNVANILHQRENNETDNHGNTME--QVRIVTLKSALVSOFRKOF QLYKVREVNDY
984

WP_023548323
914
AD KARFIHRQLVETRQITKNVANILHQRFNYKTDDNEDTME--PVRIVTLKSALVSQFRKOF QLYKVREVNDY
984

WP_031665337
914
AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNDY
984

WP_031669209
914
AD KARFIHRQLVETROITKNVANILHQRFNYKTDGNKDTME--TVRIVTLKSALVSQFRKOF QFYKVREVNDY
984

WP_033920898
914
AD KARFIHRQLVETRQITKNVANILHQRFNYKTDDNEDTME--PVRIVTLKSALVSQFRKOF QLYKVREVNDY
984

AKI42028
917
AD KARFIHRQLVETROITKNVANILHQRFNNETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNDY
987

AKI50529
917
AD KARFIHRQLVETROITKNVANILHQRFNYKTDDNEDTME--PVRIVTLKSALVSQFRKOF QLYKVREVNDY
987

EFR83390
362
AD KARFIHRQLVETRQITKNVANILHQRENNETDNHGNTME--QVRIVTLKSALVSQFRKOF QLYKVREVNDY
432

WP_046323366
914
AD KARFIHRQLVETRQITKNVANILHQRFNCKKDESGNVIE--QVRIVTLKAALVSQFRKOF QLYKVREVNDY
984

AKE81011
927
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
997

CUO82355
921
RD EERFINROLVETRQITKNVTQIIEDHYST-------------TKVAAIRANLSHEFRVKN HIYKNRDINDY
980

WP_033162887
923
KD KERFINROLVETRQIIKNVAVIINDHYTN-------------TNIVTVRAELSHQFRERY KIYKNRDINDF
982

AGZ01981
944
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
1014

AKA60242
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDE QFYKVREINNY
981

AKS40380
911
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDERKDF QFYKVREINNY
981

4UN5_B
915
LD KAGFIKRQLVETROITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY
985

WP_010922251
982

embedded image

1051

WP_039695303
992
HHAHDAYLNAVVGTALLKKYPKL-ASEFVYGEYKKYDI S---SD------ KATAK--YfFYSNLM-NFFKTKVK
1058

WP_045635197
984
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGEYQKYDL SkdpKEV---EK ATEKY--F-FYSNLL-NFFKEEVH
1055

5AXW_A
703
HHAEDALI--------------IaNADFIFKEWKKLDK Nq-mFE----EK ETEQEykEiFITPHQiKHIKDFKD
771

WP_009880683
666
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDI S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
735

WP_010922251
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_011054416
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_011284745
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_011285506
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_011527619
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_012560673
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDI S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_014407541
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1050

WP_020905136
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_023080005
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1050

WP_023610282
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1050

WP_030125963
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_030126706
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_031488318
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_032460140
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDI S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_032461047
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDI S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_032462016
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_032462936
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_032464890
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_033888930
807
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
876

WP_038431314
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_038432938
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1050

WP_038434062
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

BAQ51233
893
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
962

KGE60162
157
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
226

KGE60856

-------------------------------------- ------------ ------------------------

WP_002989955
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_003030002
981
HHAHDAYLNAVVGNALLLKYPQL-EPEFVYGEYPKYN- S---YR---sRK SATEK--FIFYSNIL-RFFKKE--
1041

WP_003065552
992
HHAHDAYLNAVVGTALLKKYPKL-ASEFVYGEYKKYDI S---SD------ KATAK--YfFYSNLM-NFFKRVIR
1058

WP_001040076
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040078
987
HHAHDAYLNAVVAKAILTKYPQL-EPEFVYGLYRRKK- L---SKI---VR ATRKM--F-FYSNLM-NMFKRVVR
1057

WP_001040080
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040081
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040083
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040085
987
HHAHDAYLNAVVAKAILTKYPQL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040087
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040088
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040089
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040090
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040091
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040092
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040094
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040095
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040096
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040097
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040098
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040099
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040100
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040104
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040105
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040106
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040107
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040108
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040109
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_001040110
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_015058523
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017643650
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017647151
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017648376
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017649527
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017771611
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_017771984
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

CFQ25032
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

CVF16040
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

KLJ37842
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

KLJ72361
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

KLL20707
1001
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1063

KLL42645
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_047207273
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_047209694
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_050198062
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_050201642
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_050204027
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_050881965
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_050886065
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

AHN30376
987
HHAHDAYLNAVVAKAILTKYPQL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

EAO78426
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

CCW42055
987
HHAHDAYLNAVVAKAILTKYPOL-EPEFVYGDYPKYN- S---YKT---RK ATEKL--F-FYSNIM-NFFKTKVT
1049

WP_003041502
981
HHAHDAYLNAVIGTALLKKYPKL-ASEFVYGEFKKYDV S---DK---eIG KATAK--YfFYSNLM-NFFKKEVK
1050

WP_037593752
982
HHAHDAYLNAVVGNALLLKYPOL-EPEFVYGEYPKYN- S---YR---SRK SATEK--FlFYSNIL-RFFKKE--
1042

WP_049516684
982
HHAHDAYLNAVVGNALLLKYPOL-EPEFVYGEYPKYN- S---YR---SRK SATEK--FlFYSNIL-RFFKKE--
1042

GAD46167
981
HHAHDAYLNAVVGNALLLKYPOL-EPEFVYGEYPKYN- S---YR---SRK SATEK--FlFYSNIL-RFFKKE--
1041

WP_018363470
990
HHAHDAYLNAVVGTALLKKYPKL-APEFVYGEYKKYDV S---SDDhseMG KATAK--YfFYSNLM-NFFKRNIR
1062

WP_003043819
991
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEVK
1060

WP_006269658
981
HHAHDAYLNAVVGNALLLKYPOL-EPEFVYGEYPKYN- S---YR---SRK SATEK--FlFYSNIL-RFFKKE--
1041

WP_048800889
981
HHAHDAYLNAVVGTALLKKYPKL-TSEFVYGEYKKYDV S---DND--eIG KATAK--YfFYSNLM-NFFKKEVK
1051

WP_012767106
981
HHAHDAYLNAVVGTALIKKYTKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_014612333
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_015017095
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_015057649
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_048327215
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_049519324
981
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKR--F-FYSNIM-NFFKTEIT
1050

WP_012515931
981
HHAHDAYLNAVVAKAILGKYPQL-APEFVYGDYPKYN- S---FKEr--QK ATQKM--L-FYSNIL-KFFKDQES
1043

WP_021320964
981
HHAHDAYLNAVVAKAILGKYPQL-APEFVYGDYPKYN- S---FKEr--QK ATQKT--L-FYSNIL-KFFKDQES
1043

WP_037581760
981
HHAHDAYLNAVVAKAILGKYPQL-APEFVYGDYPKYN- S---FKEr--QK ATQKT--L-FYSNIL-KKFKDQES
1043

WP_004232481
989
HHAHDAYLNAVVGTALLKKYPKL-APEFVYGEYKKYDV S---SDNhseLG KATAK--YfFYSNLM-NFFKTEVK
1061

WP_009854540
990
HHAHDAYLNAVVGTALLKKYPKL-ASEFVYGEYKKYDI S---SD------ KATAK--YfFYSNLM-NFFKTKVK
1056

WP_012962174
990
HHAHDAYLNAVVGTALLKKYPKL-APEFVYGEYKKYDI S---GD------ KATAK--YfFYSNLM-NFFKRVIR
1056

WP_039695303
992
HHAHDAYLNAVVGTALLKKYPKL-ASEFVYGEYKKYDI S---SD------ KATAK--YfFYSNLM-NFFKTKVK
1058

WP_014334983
989
HHAHDAYLNAVVGTALLKKYPKL-TPEFVYGEYKKYDV S---SDDyseMG KATAK--YfFYSNLM-NFFKTEVK
1061

WP_003099269
982
HHAQDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHYDL P---DSS1--GK ATTRM--F-FYSNLM-NFFKKEIK
1051

AHY15608
982
HHAQDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHYDL P---DSS1--GK ATTRM--F-FYSNLM-NFFKKEIK
1051

AHY17476
982
HHAQDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHYDL P---DSS1--GK ATTRM--F-FYSNLM-NFFKKEIK
1051

ESR09100

-------------------------------------- ------------ ------------------------

AGM98575
982
HHAQDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHYDL P---DSS1--GK ATTRM--F-FYSNLM-NFFKKEIK
1051

ALF27331
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_018372492
995
HHAHDAYLNAVVAQALLKVYPKF-ERELVYGSYVKESI ----FS----RK ATERM---rMYNNIL-KFISKD--
1055

WP_045618028
985
HHAHDPYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL TkdpKEV---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

WP_045635197
984
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGEYQKYDL SkdpKEV---EK ATEKY--F-FYSNLL-NFFKEEVH
1055

WP_002263549
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002263887
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002264920
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002269043
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002269448
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002271977
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002272766
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HE---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002273241
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002275430
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HE---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002275430
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002276448
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---YR---eRK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002277050
984
HHAHDAYLNAVVVKALLVKYPKL-EPEFVYGEYPLYN- S---YR---eRK ATQKM--F-FYSNIM-NMFKSKVK
1046

WP_002277364
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002279025
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HE---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002279859
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002280230
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002281696
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002282247
984
HHAHDAYLNAVVVKALLVKYPKL-EPEFVYGDYPHFH- S---YR---eRK ATQKM--F-FYSNIM-NMFKSKVK
1046

WP_002282906
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002283846
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002287255
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002288990
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002289641
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002290427
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002295753
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002296423
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002304487
996
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKG--
1055

WP_002305844
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002307203
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002310390
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002310390
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_002352408
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_012997688
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_014677909
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019312892
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019313659
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019314093
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HE---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019315370
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019803776
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_019805234
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_024783594
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_024784288
984
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- S---YR---eRK ATQKM--F-FYSNIM-NMFKSKVK
1046

WP_024784666
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_024784894
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_024786433
984
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- S---YR---eRK ATQKM--F-FYSNIM-NMFKSKVK
1046

WP_049473442
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HE---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

WP_049474547
982
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1041

EMC03581
975
HHAHDAYLNAVIGKALLGVYPQL-EPEFVYGDYPHFH- G---HK---eNK ATAKK--F-FYSNIM-NFFKKD--
1034

WP_000428612
987
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SkdpKEI---EK ATEKY--F-FYSNLL-NFFKEEVH
1058

WP_000428613
985
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SrnpKEV---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

WP_049523028
980
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL TkdpKEI---EK ATEKY--F-FYSNLL-NFFKDKVY
1051

WP_003107102
951
HHAHDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHYDL S---DTSl--GK ATAKM--F-FYSNIM-NFFKKEVR
1020

WP_054279288
983
HHAHDAYLNAVVGTALLKKYPKL-ASEFVYGDYQKYDL S---GKAs--GK ATAKY--F-FYSNLM-NFFKSEVK
1052

WP_049531101
985
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SrdpKEI---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

WP_049538452
985
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SkdpKDI---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

WP_049549711
987
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKNDL SkdpKDI---EK ATEKY--F-FYSNLL-NFFKEEVH
1058

WP_007896501
988
HHAHDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHFDL S---DPSl--GK ATAKV--F-FYSNIM-NFFKEELS
1057

EFR44625
940
HHAHDAYLNAVVGTALLKKYPKL-EAEFVYGDYKHFDL S---DPSl--GK ATAKV--F-FYSNIM-NFFKEELS
1009

WP_002897477
984
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL FkpsKEI---EK ATEKY--F-FYSNLL-NFFKEEVL
1055

WP_002906454
984
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SkasNTI---EK ATEKY--F-FYSNLL-NFFKEEVR
1055

WP_009729476
985
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SkdpKEI---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

CQR24647
984
HHAHDAYLNAVVAKALLIRYPKL-EPEFVYGEYPKYN- S---YRE---EK ATEKM--F-FYSNIM-NMFKTTIK
1046

WP_000066813
989
HHAHDAYLNAVLAKAILKKYPKL-EPEFVYGDYQKYDL SrepKEV---EK ATQKY--F-FYSNLL-NFFKEEVH
1060

WP_009754323
985
HHAHDAYLNAVVAKAILKKYPKL-EPEFVYGDYQKYDL SkdpKEI---EK ATEKY--F-FYSNLL-NFFKEEVH
1056

WP_044674937
986
HHAHDAYLNAVVATALLKKYPQL-APEFVYGDYPKYN- S---YKS---EK ATEKV--L-FYSNIM-NFFRRVLV
1048

WP_044676715
988
HHAHDAYLNAVVATALLKKYPQL-APEFVYGDYPKYN- S---YKS---EK ATEKV--L-FYSNIM-NFFRRVLV
1050

WP_044680361
988
HHAHDAYLNAVVATALLKKYPQL-APEFVYGDYPKYN- S---YKS---EK ATEKV--L-FYSNIM-NFFRRVLV
1050

WP_044681799
986
HHAHDAYLNAVVATALLKKYPQL-APEFVYGDYPKYN- S---YKS---EK ATEKV--L-FYSNIM-NFFRRVLV
1048

WP_049533112
981
HHAHDAYLNAVIGTALLKKYPKL-ASEFVYGEFKKYDV S---DK---eIG KATAK--YfFYSNLM-NFFKKEVK
1050

WP_029090905
952
HHAQDAFLVAFLGTNITSNYPKI-EMEYLFKGYQHYLN ------Ev--GK AAKPKftF-IVENLS---------
1007

WP_006506696
977
HHAHDAYIVALIGGFMRDRYPNMhDSKAVYSEYMKMGR ----NKNd--QK -----G---FVINSM-NYPY-EV-
1038

AIT42264
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_034440723
981
HHAHDAYLNGVIALKLLELYPYM-AKDLIYGKYSYHRK G---------DK ATQAK--Y-KMSNII-ERFSQDL-
1041

AKQ21048
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

WP_004636532
981
HHGHDAYLNAVVATTIMKVYPNL-KPQFVYGQYKKTSM ----FKE---EK ATARK--H-FYSNIT-KFFKKEKV
1042

WP_002364836
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---EK ATAKA--I-IYTNLL-RFFTED--
1047

WP_016631044
939
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
998

EMS75795
723
HHAHDAYLNGVVAIALLKKYPKL-EPEFVYGNYTKENL ----AT---eNK ATAKK--E-FYSNIL-RFFEKE--
782

WP_002373311
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQA ----FKE---NK ATAKT--I-IYTNLM-RFFTED--
1047

WP_002378009
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_002407324
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_002413717
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_010775580
990
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQA ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1049

WP_010818269
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_010824395
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKT--I-IYTNLM-RFFTED--
1047

WP_016622645
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQT ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_033624816
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQA ----FKE---NK AMAKA--I-IYTNLL-RFFTED--
1047

WP_033625576
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQA ----FKE---NK ATAKA--I-IYTNLM-RFFTEV--
1047

WP_033789179
988
HHGQDAYLNCVVATTLLKVYPNL-APEFVYGEYPKFQA ----FKE---NK ATAKA--I-IYTNLL-RFFTED--
1047

WP_002310644
989
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1048

WP_002312694
990
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_002314015
990
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_002320716
990
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_002330729
989
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1048

WP_002335161
990
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_002345439
990
HHAHDAYLNGVVALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_034867970
980
HHAHDAYLNGFIANVLLKRYPKL-APEFVYGKYVKYSL ----AR---eNK ATAKK--E-FYSNIL-KFLESD--
1039

WP_047937432
990
HHAHDAYLNGVIALALLKKYPQL-APEFVYGEYLKFNA ----HK---aNK ATVKK--E-FYSNIM-KFFESD--
1049

WP_010720994
980
HHAHDAYLNGFIANVLLKRYPKL-APEFVYGKYVKYSL ----AR---eNK ATAKK--E-FYSNIL-KFLESD--
1039

WP_010737004
980
HHAHDAYLNGFIANVLLKRYPKL-APEFVYGKYVKYSL ----AR---eNK ATAKK--E-FYSNIL-KFLESD--
1039

WP_034700478
980
HHAHDAYLNGFIANVLLKRYPKL-APEFVYGKYVKYSL ----AR---eNK ATAKK--E-FYSNIL-KFLESD--
1039

WP_007209003
978
HHAHDAYLNAVVALSLLRVYPQL-KPEFVYGEYGKNS- ----IHDq--NK ATIKK---qFYSNIT-RYFASK--
1037

WP_023519017
974
HHAHDAYLNGVVAMTLLKKYPKL-APEFVYGSYIKGDI ----NQ---iNK ATAKK--E-FYSNIM-KFFESE--
1033

WP_010770040
986
HHGHDAYLNGVVANSLLRVYPQL-QPEFVYGDYPKENA ----YKA---NK ATAKK--Q-LYTNIM-KFFAED--
1045

WP_048604708
983
HHAHDAYLNGVVATALLKIYPOL-EPEFVYGEFHRFNA ----FKE---NK ATAKK--Q-FYSNLM-EFSKSD--
1042

WP_010750235
983
HHAHDAYLNAVVALALLKKYPRL-APEFVYGSFAKFHL ----VK---eNK ATAKK--E-FYSNIL-KFFEKE--
1042

AII16583
1021
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1090

WP_029073316
988
HHAHDAYIATILGTYIGHRFESL-DAKYIYGEYQKIFR ----NKNk--DK ---KDg---FILNSM-RNLYADK-
.052

WP_031589969
988
HHAHDAYIATILGTYIGHRFESL-DAKYIYGEYKRIFR ----QKNk--GK ---NDg---FILNSM-RNIYADK-
1052

KDA45870
973
HHAHDAYLNAVVANLIMAKYPEL-EPEFVYGKYRKTK- ----FKG1--GK ATAKN---tLYANVL-YELKENEV
1034

WP_039099354
991
HHAFDAYLTAFVGLYLLKRYPKL-KPYFVYGEYQKAS- ----QQ----DK ---RN--F----NFL-NGLKKD--
1043

AKP02966
1000
HHAQDAYLASFLGTYRLRRFPTD-EMLLMNGEYNKFYG -----KElysKK -SRKN-gF-IISPLV---------
1062

WP_010991369
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGDYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_033838504
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGDYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

EHN60060
988
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGDYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1047

EFR89594
754
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGDYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
813

WP_038409211
985
HHAHDAYLNGVVANTLLKVYPOL-EPEFVYGDYHOFDW ----FKA---NK ATAKK--Q-FYTNIM-RFFAKE--
1044

EFR95520
604
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGDYHOFDW ----FKA---NK ATAKK--Q-FYTNIM-RFFAKE--
663

WP_003723650
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_003727705
985
HHAHDAYLNGVVANTLLKVYPOL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_003730785
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_003733029
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFGW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_003739838
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_014601172
985
HHAHDAYLNGVVANTLLKVYPOL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFGQK--
1044

WP_023548323
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_031665337
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_031669209
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

WP_033920898
985
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1044

AKI42028
988
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFGQK--
1047

AKI50529
988
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
1047

EFR83390
433
HHAHDAYLNGVVANTLLKVYPQL-EPEFVYGEYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAQK--
492

WP_046323366
985
HHAHDAYLNCVVANTLLKVYPQL-EPEFVYGDYHQFDW ----FKA---NK ATAKK--Q-FYTNIM-LFFAKK--
1044

AKE81011
998
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1067

CUO82355
981
HHAHDAYIVALIGGFMRDRYPNMhDSKAVYSEYMKMER ----NKNd--QK -----g---FVINSM-NYPY-EV-
1042

WP_033162887
983
HHAHDAYIACIVGQFMHONFEHL-DAKIIYGQYK---- -----KNy--KK ---NYg---FILNSM-NHLQSDI-
1042

AGZ01981
1015
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1084

AKA60242
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

AKS40380
982
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1051

4UN5_B
986
HHAHDAYLNAVVGTALIKKYPKL-ESEFVYGDYKVYDV S---EQEi--GK ATAKY--F-FYSNIM-NFFKTEIT
1055

WP_010922251
1052

embedded image

1114

WP_039695303
1059
YAD-GTVFERPIIE T-NAD-GE-IAWNKQIDFEKVRKVLS-YPQVNIVKKVETQT GGFSK ESIL-PKG-
1120

WP_045635197
1056
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFAIIKKVLS-LPQVNIVKKREVQT GGFSK ESIL-PKG-
1118

5AXW_A
772
YKYSHRVDKKPNRE VNNLN-GL---YDKDND--KLKKLINKSPEKLLMYHHDPQT --YQK KLIMeQYGd
852

WP_009880683
736
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
798

WP_010922251
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_011054416
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_011284745
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_011285506
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_011527619
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_012560673
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_014407541
1051
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1113

WP_020905136
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_023080005
1051
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1113

WP_023610282
1051
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1113

WP_030125963
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_030126706
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_031488318
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_032460140
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_032461047
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_032462016
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_032462936
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_032464890
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_033888930
877
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
939

WP_038431314
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_038432938
1051
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1113

WP_038434062
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

BAQ51233
963
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1025

KGE60162
227
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
289

KGE60856
1
------------IE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
52

WP_002989955
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_003030002
1042
-----------DIQ T-NED-GE-IAWNKEKHIKILRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1093

WP_003065552
1059
YSN-GKVIVRPVVE Y-SKD-TEdIAWDKKSNFRTICKVLS-YPQVNIVKKVETOT GGFSK ESIL-PKG-
1121

WP_001040076
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040078
1058
LAD-GSIVVRPVIE TGRYM-GK-TAWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1120

WP_001040080
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040081
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040083
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040085
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040087
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040088
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040089
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040090
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040091
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040092
1050
LAD-ETVVVKDDIE VNNET-GE-IAWDKKKHFATVRKVLS-YPQVNIVKKTEVQT GGFSK ESIL-AHS-
1112

WP_001040094
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040095
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEVQT GGFSK ESIL-AHG-
1112

WP_001040096
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEVQT GGFSK ESIL-AHG-
1112

WP_001040097
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040098
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040099
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040100
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040104
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040105
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040106
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040107
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040108
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040109
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_001040110
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_015058523
1050
LAD-ETVVVKDDIE VNNET-GE-IAWDKKKHFATVRKVLS-YPQVNIVKKTEVQT GGFSK ESIL-AHS-
1112

WP_017643650
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_017647151
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_017648376
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_017649527
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_017771611
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_017771984
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

CFQ25032
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

CFV16040
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

KLJ37842
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

KLJ72361
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

KLL20707
1064
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1126

KLL42645
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_047207273
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_047209694
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_050198062
1050
LAD-GTVVIKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_050201642
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_050204027
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQVNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_050881965
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPONNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_050886065
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

AHN30376
1050
LAD-ETVVVKDDIE VNNET-GE-IAWDKKKHFATVRKVLS-YPQVNIVKKTEVQT GGFSK ESIL-AHS-
1112

EAO78426
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

CCW42055
1050
LAD-GTVVVKDDIE VNNDT-GE-IVWDKKKHFATVRKVLS-YPQNNIVKKTEIQT GGFSK ESIL-AHG-
1112

WP_003041502
1051
FAD-GTVVERPDIE T-SED-GE-IAWNKQTDFKIVRKVLS-YPQVNIVKKTEVQT HGLDR PSPK-PKP-
1122

WP_037593752
1043
-----------DIQ T-NED-GE-IAWNKEKHIKILRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1094

WP_049516684
1043
-----------DIQ T-NED-GE-IAWNKEKHIKILRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1094

GAD46167
1042
-----------DIQ T-NED-GE-IAWNKEKHIKILRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1093

WP_018363470
1063
YSN-GKVIVRPVVE Y-SKDtGE-IAWNKRTDFEKVRKVLS-YPQVNIVKKVETQT GGFSK ESIL-PKG-
1125

WP_003043819
1061
LAN-GEIRKRPLIE TNGET-GE-VVWNKEKDFATVRKVLA-MPQVNIVKKTEVQT GGFSK ESIL-SKR-
1123

WP_006269658
1042
-----------DIQ T-NED-GE-IAWNKEKHIKILRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1093

WP_048800889
1052
FAD-GTVVERPDIE T-SED-GE-IAWNKQTDFKIVRKVLS-YPQVNIVKKVEKQT GRFSK ESIL-PKG-
1113

WP_012767106
1051
LAN-GEIRKRPLIE TNEET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_014612333
1051
LAN-GEIRKRPLIE TNEET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_015017095
1051
LAN-GEIRKRPLIE TNEET-GE-IVWNKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_015057649
1051
LAN-GEIRKRPLIE TNEET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_048327215
1051
LAN-GEIRKRPLIE TNEET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_049519324
1051
LAN-GEIRKRPLIE TNEET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GALTN ESIY-ARG-
1113

WP_012515931
1044
L------------H VNSD--GE-EIWNANKHLPIIKNVLS-IPQVNIVKKTEVQT GGFYK ESIL-SKG-
1094

WP_021320964
1044
L------------H VNSD--GE-EIWNANKHLPIIKNVLS-IPQVNIVKKTEVQT GGFYK ESIL-SKG-
1094

WP_037581760
1044
L------------H VNSD--GE-EIWNANKHLPIIKNVLS-IPQVNIVKKTEVQT GGFYK ESIL-SKG-
1094

WP_004232481
1062
YAD-GRVFERPDIE T-NAD-GE-VVWNKQRDFNIVRKVLS-YPQVNIVKKVEVQT GGFSK ESIL-PKG-
1123

WP_009854540
1057
YAD-GTVFERPIIE T-NAD-GE-IAWNKQIDFEKVRKVLS-YPQVNIVKKVETQT GGFSK ESIL-PKG-
1118

WP_012962174
1057
YSN-GKVVVRPVIE C-SKDtGE-IAWNKQTDFEKVRRVLS-YPQVNIVKKVETQT GGFSK ESIL-PKG-
1119

WP_039695303
1059
YAD-GTVFERPIIE T-NAD-GE-IAWNKQIDFEKVRKVLS-YPQVNIVKKVETQT GGFSK ESIL-PKG-
1120

WP_014334983
1062
YAD-GRVFERPDIE T-NAD-GE-VVWNKQKDFDIVRKVLS-YPQVNIVKKVEAQT GGFSK ESIL-SKG-
1123

WP_003099269
1052
LAD-DTIFTRPQIE VNTET-GE-IVWDKVKDMQTIRKVMS-YPQVNIVMKTEVQT GGFSK ESIW-PKG-
1114

AHY15608
1052
LAD-DTIFTRPQIE VNTET-GE-IVWDKVKDMQTIRKVMS-YPQVNIVMKTEVQT GGFSK ESIW-PKG-
1114

AHY17476
1052
LAD-DTIFTRPQIE VNTET-GE-IVWDKVKDMQTIRKVMS-YPQVNIVMKTEVQT GGFSK ESIW-PKG-
1114

ESR09100

-------------- ----------------------------------------- ----- ---------

AGM98575
1052
LAD-DTIFTRPQIE VNTET-GE-IVWDKVKDMQTIRKVMS-YPQVNIVMKTEVQT GGFSK ESIW-PKG-
1114

ALF27331
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_018372492
1056
--K----------K --DQEtGE-IVWDKKEIENIVKKVIY-SSPVNIVKKREEQS GALFK QSNM-AVGy
1108

WP_045618028
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKVLS-LPQVNIVKKTEEQT GGLFD NNIV-SKKk
1124

WP_045635197
1056
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFAIIKKVLS-LPQVNIVKKREVQT GGFSK ESIL-PKG-
1118

WP_002263549
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002263887
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002264920
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002269043
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002269448
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002271977
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002272766
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002273241
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002275430
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002276448
1042
-----------DVR T-DRN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002277050
1047
LAD-DQIVERPMIE VNDET-GE-IAWDKTKHITTVKKVLS-YPQVNIVKKVEEQT GGLED -----PKS-
1111

WP_002277364
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002279025
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002279859
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002280230
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002281696
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002282247
1047
LAD-DQIVERPMIE VNDET-GE-IAWDKTKHITTVKKVLS-YPQVNIVKKVEEQT GGLFD -----PKS-
1111

WP_002282906
1042
-----------DVR I-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002283846
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002287255
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002288990
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002289641
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002290427
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFFK ESIL-PKG-
1093

WP_002295753
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002296423
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002304487
1056
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1107

WP_002305844
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002307203
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_002310390
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFFK ESIL-PKG-
1093

WP_002352408
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_012997688
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_014677909
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019312892
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019313659
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019314093
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019315370
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019803776
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_019805234
1042
-----------DVR T-DKN-GE-IIWKKDEYISNIKKVLS-YPQVNIVKKVEEQT GGFFK ESIL-PKG-
1093

WP_024783594
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_024784288
1047
LAD-DQIVERPMIE VNDET-GE-IAWDKTKHITTVKKVLS-YPQVNIVKKVEEQT GGLED -----PKS-
1111

WP_024784666
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_024784894
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_024786433
1047
LAD-DQIVERPMIE VNDET-GE-IAWDKTKHITTVKKVLS-YPQVNIVKKVEEQT GGLFD -----PKS-
1111

WP_049473442
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

WP_049474547
1042
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1093

EMC03581
1035
-----------DVR T-DKN-GE-IIWKKDEHISNIKKVLS-YPQVNIVKKVEEQT GGFSK ESIL-PKG-
1086

WP_000428612
1059
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKVLS-LPQVNIVKKREVQT GGFSK ESIL-PKG-
1121

WP_000428613
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKVLS-YPQVNIVKKREVQT GGFSK ESIL-PKG-
1119

WP_049523028
1052
YAD-GTIIQRGNVE Y-SKDtGE-IAWNKKRDFAIVRKVLS-YPQVNIVKKTEEQT GGFSK ESIL-PKG-
1114

WP_003107102
1021
LAD-GTVITRPQIE TNTET-GE-IVWDKVKDIKTIRKVLS-IPQINVVKKTEVQT GGFSK ESIL-SKR-
1083

WP_054279288
1053
LAN-GNIIKRSPIE VNEET-GE-IVWDKTKDFGTVRKVLS-APQVNIVKKTEIQT GGFSN ETIL-SKG-
1115

WP_049531101
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEIDFATIRKILS-LSQVNIVKKTEEQT GGLFD NNIV-SKKk
1124

WP_049538452
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKILS-LPQVNIVKKTEEQT GGLFD NNIV-SKKk
1124

WP_049549711
1059
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKVLS-YPQVNIVKKTEEQT GGLFD NNIV-SKEk
1126

WP_007896501
1058
LAD-GTLMKRPVIE TNTET-GE-VVWDKVKDFKTIRKVLS-YPQVNIVKKTEIQS GAFSK ESVL-SKG-
1120

EFR44625
1010
LAD-GTLMKRPVIE TNTET-GE-VVWDKVKDFKTIRKVLS-YPQVNIVKKTEIQS GAFSK ESVL-SKG-
1072

WP_002897477
1056
YAD-GTIRKRENIE Y-SKDtGE-IAWDKEKDFATIKKVLS-YPQVNIVKKREVQT GGFSK ESIL-PKG-
1118

WP_002906454
1056
YAD-GTIKKRENIE Y-SNDtGE-IAWNKEKDFATIKKVLS-LPQVNIVKKTEEQT GGLFD NNIV-SKKk
1123

WP_009729476
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATIKKVLS-LPQVNIVKKREVQT GGFSK ESIL-PKG-
.119

CQR24647
1047
LAD-GRVVEKPVIE ANEET-GE-IAWDKTKHFANVKKVLS-YPQVSIVKKVEEQT GGFSK ESIL-PKG-
1109

WP_000066813
1061
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFATVKKVLS-LPQVNIVKKTEVQT GGFSK ESIL-PKG-
1123

WP_009754323
1057
YAD-GTIVKRENIE Y-SKDtGE-IAWNKEKDFVTIKKVLS-YPQVNIVKKREVQT GGFSK ESIL-PKG-
1119

WP_044674937
1049
YSKtGEVRIRPVIE VNKET-GE-IVWDKKSDFRTVRKVLS-YPQVNVVKKVEMQT GGFSK ESIL-QHG-
1112

WP_044676715
1051
YSKtGEVRIRPVIE VNKET-GE-IVWDKKSDFRTVRKVLS-YPQVNVVKKVEMQT GGFSK ESIL-QHG-
1114

WP_044680361
1051
YSKtGEVRIRPVIE VNKET-GE-IVWDKKSDFRTVRKVLS-YPQVNVVKKVEMQT GGFSK ESIL-QHG-
1114

WP_044681799
1049
YSKtGEVRIRPVIE VNKET-GE-IVWDKKSDFKTVRKVLS-YPQVNVVKKVEMQT GGFSK ESIL-QHG-
1112

WP_049533112
1051
FAD-GTVVERPDIE T-SED-GE-IAWNKQTDFKIVRKVLS-YPQVNIVKKTEVQT HGLDR PSPK-PKP-
1122

WP_029090905
1008
-KQ----------Q --NSTtGE-VKWNPEVDIAKLKRILN-FKQCNIVRKVEEQS GALFK ETIY-PVEe
1061

WP_006506696
1039
--D----------- ------GK-LIWNP-DLINEIKKCFY-YKDCYCTTKLDOKS GQLEN -TVL-SNDa
1084

AIT42264
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_034440723
1042
------------LA --NPD-GE-IAWEKDKDLNTIRKVLS-SKQINIIKKAEEGK GRLFK ETIN-SRPS
1092

AKQ21048
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

WP_004636532
1043
-------------- VNEET-GE-ILWDTERHLSTIKRVLS-WKOMNIVKKVEKQK GQLWK ETIY-PKG-
1092

WP_002364836
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_016631044
999
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVOK GGFSK ESIK-PKG-
1049

EMS75795
783
--E----------Y SYDEN-GE-IFWDKARHIPQIKKVIS-SHQVNIVKKVEVQT GGFYK ETVN-PKG-
834

WP_002373311
1048
--E----------P RFTKD-SE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_002378009
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_002407324
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_002413717
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHQMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_010775580
1050
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1100

WP_010818269
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_010824395
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHQMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_016622645
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHQMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_033624816
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVOK GGFSK ESIK-PKG-
1098

WP_033625576
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHOMNIVKKVEVOK GGFSK ESIK-PKG-
1098

WP_033789179
1048
--E----------P RFTKD-GE-ILWSN-SYLKTIKKELN-YHQMNIVKKVEVQK GGFSK ESIK-PKG-
1098

WP_002310644
1049
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1100

WP_002312694
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_002314015
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_002320716
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_002330729
1049
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSE ETVE-PKK-
1100

WP_002335161
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_002345439
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_034867970
1040
--E----------P FCDEN-GE-IYWEKSHHLPRIKKVLS-SHQVNVVKKVEQQK GGFYK ETVN-SKE-
1091

WP_047937432
1050
--T----------P VCDEN-GE-IFWDKSKSIAQVKKVIN-HHHMNIVKKTEIQK GGFSK ETVE-PKK-
1101

WP_010720994
1040
--E----------P FCDEN-GE-IYWEKSHHLPRIKKVLS-SHQVNVVKKVEQQK GGFYK ETVN-SKE-
1091

WP_010737004
1040
--E----------P FCDEN-GE-IYWEKSHHLPRIKKVLS-SHQVNVVKKVEQQK GGFYK ETVN-SKE-
1091

WP_034700478
1040
--E----------P FCDEN-GE-IYWEKSHHLPRIKKVLS-SHQVNVVKKVEQQK GGFYK ETVN-SKE-
1091

WP_007209003
1038
--D----------- IINDD-GE-ILWNKQETIAQVIKTLG-MHQVNVVKKVEIQK GGFSK ESIQ-PKG-
1089

WP_023519017
1034
--E----------I ICDEQ-GE-VIWNKKRDLSTIKKTIG-AHQVNIVKKVEKQK GGFYK ETIN-SKA-
1085

WP_010770040
1046
--A----------V IIDEN-GE-ILWDK-KNIATVKKVMS-YPQMNIVKKPEIQT GSFSK ETIK-PKG-
1096

WP_048604708
1043
--K----------V IIDEN-GE-ILWNQ-KKIVTVKKVMN-YRQMNIVKKVEIQK GGFSK ESIL-PKG-
1093

WP_010750235
1043
--E----------Q FCDEN-GE-IFWDKRKHIQQIKKVIS-SHQVNIVKKVEVQT GSFYK ETVN-TKE-
1094

AII16583
1091
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1153

WP_029073316
1053
--D----------- ----T-GE-VVWDP-EWISRIKKCFY-YKDCFVTKKLEENN GSFFN -TVR-PNDe
1099

WP_031589969
1053
--D----------- ----T-GE-IVWDP-NYIDRIKKCFY-YKDCFVTKKLEENN GTFFN -TVL-PNDt
1099

KDA45870
1035
YPF----------- -----------WDKARDLPTIKRYLY-RAQVNKVRKAERQT GGFSD EMLV-PKS-
1078

WP_039099354
1044
-------------E LVDEN-TEaVIWNKESGLAYLNKIYQ-FKKILVTREVHENS GALEN QTLYaAKDd
1097

AKP02966
1063
--N-------GTTQ --DRNtGE-IIWNVG-FRDKILKIFN-YHQCNVTRKTEIKT GQFYD QTIYSPKNp
1118

WP_010991369
1045
--D----------R IIDEN-GE-ILWDK-KYLDTVKKVMS-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_033838504
1045
--D----------R IIDEN-GE-ILWDK-KYLDTVKKVMS-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
1095

EHN60060
1048
--D----------R IIDEN-GE-ILWDK-KYLDTVKKVMS-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
1098

EFR89594
814
--D----------R IIDEN-GE-ILWDK-KYLDTVKKVMS-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
864

WP_038409211
1045
--N----------Q IIDKN-GE-ILWDN-RYLDTIKKVLS-YROMNIVKKTEIQK GEFSN ATVN-PKG-
1095

EFR95520
664
--N----------Q IIDKN-GE-ILWDN-RYLDTIKKVLS-YROMNIVKKTEIQK GEFSN ATVN-PKG-
714

WP_003723650
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YROMNIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_003727705
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YRQINIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_003730785
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YRQINIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_003733029
1045
--D----------R IIDEN-GE-ILWDK-RYLETVKKVLG-YRQMNIVKKTEIQK GEFSN VTPN-PKG-
1095

WP_003739838
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_014601172
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YROMNIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_023548323
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLN-YROMNIVKKTEIQK GEFSN QNPK-PRG-
1095

WP_031665337
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YROMNIVKKTEIQK GEFSK ATIK-PKG-
1095

WP_031669209
1045
--E----------R IIDEN-GE-ILWDK-RYLETVKKVLG-YROMNIVKKTEIQK GEFSN VTPN-PKG-
1095

WP_033920898
1045
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLN-YRQMNIVKKTEIQK GEFSN QNPK-PRG-
1095

AKI42028
1048
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
1098

AKI50529
1048
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLN-YRQMNIVKKTEIQK GEFSN QNPK-PRG-
1098

EFR83390
493
--E----------R IIDEN-GE-ILWDK-KYLETIKKVLD-YRQMNIVKKTEIQK GEFSK ATIK-PKG-
543

WP_046323366
1045
--D----------R IIDEN-GE-ILWDK-KYLDTIKKVLN-YRQMNIVKKTEIQK GEFSN ATAN-PKG-
1095

AKE81011
1068
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1130

CUO82355
1043
--D----------- ------GK-LIWNP-DLINEIKKCFY-YKDCYCTTKLDQKS GQMFN -TVL-PNDa
1088

WP_033162887
1043
--D----------- ----T-GE-VMWDP-AKIGKIKSCFY-YKDVYVTKKLEONS GTLEN -TVL-PNDa
1089

AGZ01981
1085
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1147

AKA60242
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

AKS40380
1052
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1114

4UN5_B
1056
LAN-GEIRKRPLIE TNGET-GE-IVWDKGRDFATVRKVLS-MPQVNIVKKTEVQT GGFSK ESIL-PKR-
1118

WP_010922251
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_039695303
1121
--DSD KLIPRKTKKV-YW-DTKKYGGFDSPTVAYSV-FVVAD--VE--KGKAKKLKTVKELVGISIME RSFFEE
1185

WP_045635197
1119
--NSD KLIPRKT-KDILL-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KAAFEE
1183

5AXW_A
853
--EKN -LYKYYEeTGNYL---TKYSKKDNGPVIKKI------------KYYGNKLNAHLDITDDYPNS -VKLSL
912

WP_009880683
799
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELVGITIME RSSFEK
860

WP_010922251
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_011054416
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_011284745
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_011285506
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_011527619
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_012560673
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELVGITIME RSSFEK
1176

WP_014407541
1114
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1175

WP_020905136
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGLTIME RSSFEK
1176

WP_023080005
1114
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1175

WP_023610282
1114
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1175

WP_030125963
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_030126706
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_031488318
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_032460140
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELVGITIME RSSFEK
1176

WP_032461047
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELVGITIME RSSFEK
1176

WP_032462016
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_032462936
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_032464890
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_033888930
940
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1001

WP_038431314
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_038432938
1114
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1175

WP_038434062
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

BAQ51233
1026
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1087

KGE60162
290
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
351

KGE60856
53
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
114

WP_002989955
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_003030002
1094
--ESD KLIPRKT-KNSYW-NPKKYGGFDSPVVAYSI-LVFAD--VE--KGKSKKLRKVQDMVGITIME KKRFEK
1158

WP_003065552
1122
--DSD KLIPRKTKKA-YW-DTKKYGGFDSPTVAYSV-FVVAD--VE--KGKAKKLKTVKELVGISIME RSFFEE
1186

WP_001040076
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040078
1121
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSKFEK
1185

WP_001040080
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040081
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040083
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040085
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040087
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040088
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040089
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040090
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040091
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040092
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVLAD--IK--KGKAQKLKTVKELIGITIME RERFEK
1177

WP_001040094
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040095
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040096
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040097
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040098
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040099
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPKVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040100
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040104
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040105
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_001040106
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_001040107
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_001040108
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_001040109
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_001040110
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_015058523
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVLAD--IK--KGKAQKLKTVKELIGITIME RERFEK
1177

WP_017643650
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_017647151
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_017648376
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_017649527
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_017771611
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_017771984
1113
--NSD KLIPRKT-KDIYL-DPKKYGGEDSPIVAYSV-LVAAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

CFQ25032
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

CFV16040
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

KLJ37842
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

KLJ72361
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

KLL20707
1127
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1191

KLL42645
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_047207273
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_047209694
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_050198062
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_050201642
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_050204027
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RFRFEK
1177

WP_050881965
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_050886065
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

AHN30376
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVLAD--IK--KGKAQKLKTVKELIGITIME RERFEK
1177

EAO78426
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

CCW42055
1113
--NSD KLIPRKT-KDIYL-DPKKYGGFDSPIVAYSV-LVVAD--IK--KGKAQKLKTVTELLGITIME RSRFEK
1177

WP_003041502
1123
--DSS ENLVGVK-RNL---DPKKYGGYAGISNSYAV-LVKAI--IE--KGVKKKETMVLEFQGISILD RITFEK
1185

WP_037593752
1095
--ESD KLIPRKT-KNSYW-NPKKYGGFDSPVVAYSI-LVFAD--VE--KGKSKKLRKVQDMVGITIME KKRFEK
1159

WP_049516684
1095
--ESD KLIPRKT-KNSYW-NPKKYGGFDSPVVAYSI-LVFAD--VE--KGKSKKLRKVQDMVGITIME KKRFEK
1159

GAD46167
1094
--ESD KLIPRKT-KNSYW-NPKKYGGFDSPVVAYSI-LVFAD--VE--KGKSKKLRKVQDMVGITIME KKRFEK
1158

WP_018363470
1126
--DSD KLIPRKTKKV-LW-EPKKYGGFDSPTVAYSV-LVVAD--VE--KGKTKKLKTVKELVGISIME RSFFEK
1190

WP_003043819
1124
--ESA KLIP----RKKGW-DTRKYGGFGSPTVAYSI-LVVAK--VE--KGKAKKLKSVKVLVGITIME KGSYEK
1185

WP_006269658
1094
--ESD KLIPRKT-KNSYW-DPKKYGGFDSPVVAYSI-LVFAD--VE--KGKSKKLRKVQDMVGITIME KKRFEK
1158

WP_048800889
1114
--DSD KLIARKTKEN-YW-DTKKYGGFDSPTVAYSV-LVVAD--IK--KGKAKKLKTVKELVGISIME RPFFEK
1178

WP_012767106
1114
--SFD KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKskVQ--DGKVKKIKTGKELIGMTLLD KLVFEK
1177

WP_014612333
1114
--SFD KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKSKVQ--DGKVKKIKTGKELIGITLLD KLVFEK
1177

WP_015017095
1114
--SFD KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKskVQ--DGKVKKIKTGKELIGITLLD KLVFEK
1177

WP_015057649
1114
--SED KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKskVQ--DGKVKKIKTGKELIGITLLD KLVFEK
1177

WP_048327215
1114
--SFD KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKckVQ--DGKVKKIKTGKELIGITLLD KLVFEK
1177

WP_049519324
1114
--SFD KLIS----RKHRF-ESSKYGGFGSPTVTYSV-LVVAKskVQ--DGKVKKIKTGKELIGITLLD KLVFEK
1177

WP_012515931
1095
--NSD KLIP----RKNNW-DTRKYGGFDSPTVAYSV-LVIAK--ME--KGKAKVLKPVKEMVGITIME RTAFEE
1156

WP_021320964
1095
--NSD KLIP----RKNNW-DTRKYGGFDSPTVAYSV-LVIAK--ME--KGKAKVLKPVKEMVGITIME RIAFEE
1156

WP_037581760
1095
--NSD KLIP----RKNNW-DTRKYGGFDSPTVAYSV-LVIAK--ME--KGKAKVLKPVKEMVGITIME RIAFEE
1156

WP_004232481
1124
--DSD KLIPRKTKKL-QW-ETQKYGGFDSPTVAYSV-LVVAD--VE--KGKTRKLKTVKELVGISIME RSSFEE
1188

WP_009854540
1119
--DSD KLIPRKTKKV-YW-DTKKYGGFDSPTVAYSV-FVVAD--VE--KGKAKKLKTVKELVGISIME RSFFEE
1183

WP_012962174
1120
--NSD KLIPRKTKKF-RW-DTPKYGGFDSPNIAYSV-FVIAD--VE--KGKAKKLKTVKELVGISIME RSSFEE
1184

WP_039695303
1121
--DSD KLIPRKTKKV-YW-DTKKYGGFDSPTVAYSV-FVVAD--VE--KGKAKKLKTVKELVGISIME RSFFEE
1185

WP_014334983
1124
--DSD KLIPRKTKKV-YW-NTKKYGGFDSPTVAYSV-LVVAD--IE--KGKAKKLKTVKELVGISIME RSFFEE
1188

WP_003099269
1115
--DSD KLIA----RKKSW-DPKKYGGFDSPIIAYSV-LVVAK--IA--KGKTQKLKTIKELVGIKIME QDEFEK
1176

AHY15608
1115
--DSD KLIA----RKKSW-DPKKYGGFDSPIIAYSV-LVVAK--IA--KGKTQKLKTIKELVGIKIME QDEFEK
1176

AHY17476
1115
--DSD KLIA----RKKSW-DPKKYGGFDSPIIAYSV-LVVAK--IA--KGKTQKLKTIKELVGIKIME QDEFEK
1176

ESR09100
1
----- -------------------------------------------------------------ME QDEFEK
8

AGM98575
1115
--DSD KLIA----RKKSW-DPKKYGGFDSPIIAYSV-LVVAK--IA--KGKTQKLKTIKELVGIKIME QDEFEK
1176

ALF27331
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAN--IE--KGKSKKLKLVKDLVGITIME RTIFEK
1158

WP_018372492
1109
---NN KLIP----RKKDW-SVDKYGGFIEPAESYSLaIFYTD--IN-----GKKPKKKSTIIAISRME KKDYEK
1167

WP_045618028
1125
VVDAS KLTPIKS-G---L-SPEKYGGYARPTIAYSV-LVIAD--IE--KGKAKKLKRIKEMVGITVQD KKKFEA
1188

WP_045635197
1119
--NSD KLIPRKT-KDILL-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KAAFEE
1183

WP_002263549
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002263887
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002264920
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002269043
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002269448
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002271977
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002272766
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002273241
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002275430
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002276448
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002277050
1112
--PLE KLVPLKK----AL-NPEKYGGYOKPTTAYPI-LLIVD---------------TKQLIPISVMD KKRFEQ
1166

WP_002277364
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002279025
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002279859
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002280230
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002281696
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002282247
1112
--PLE KLVPLKK----AL-NPEKYGGYQKPTTAYPI-LLIVD---------------TKQLIPISVMD KKRFEQ
1166

WP_002282906
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002283846
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002287255
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002288990
1094
--NSY KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002289641
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002290427
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002295753
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002296423
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002304487
1108
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1172

WP_002305844
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002307203
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002310390
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_002352408
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_012997688
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_014677909
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019312892
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019313659
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019314093
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019315370
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019803776
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_019805234
1094
--DSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_024783594
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KSKSKKLKTVKALVGVTIME KMTFER
1158

WP_024784288
1112
--PLE KLVPLKK----AL-NPEKYGGYQKPTTAYPI-LLIVD---------------TKQLIPISVMD KKRFEQ
1166

WP_024784666
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_024784894
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_024786433
1112
--PLE KLVPLKK----AL-NPEKYGGYQKPTTAYPI-LLIVD---------------TKQLIPISVMD KKRFEQ
1166

WP_049473442
1094
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

WP_049474547
1094
--NSD KLIPRKT-KKFYW-DTKKYGGEDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1158

EMC03581
1087
--NSD KLIPRKT-KKFYW-DTKKYGGFDSPIVAYSI-LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER
1151

WP_000428612
1122
--NSD KLIPRKT-KDILW-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKRLKTVKTLVGITIME KATFEK
1186

WP_000428613
1120
--NSD KLIPRKT-KDILW-ETTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KAAFEE
1184

WP_049523028
1115
--NSD KLIPRKT-KNVQL-DTTKYGGFDSPVIAYSI-LLVAD--VE--KGKSKKLKTVKSLIGITIME KVKFEA
1179

WP_003107102
1084
--DSD KLIP----RKNNW-DPKKYGGFGSPIIAYSV-LVVAK--VT--KGKSQKTKSVKELVGITIME QNEFEK
1145

WP_054279288
1116
--KSS KLIP----RKNKWrDTTKYGGFNTPTVAYSV-LVVAK--VE--KGKAKKLKPVKELVGITIME RTKFEA
1178

WP_049531101
1125
vvDAS KLIPIKS-G---L-SPEKYGGYARPTIAYSV-LVIAD--IE--KGKAKKLKRIKEMVGITIQD KKKFEA
1188

WP_049538452
1125
vvDAS KLIPIKS-G---L-SPEKYGGYARPTIAYSV-LVIAD--IE--KGKTKKLKRIKEMIGITVQD KKIFES
1188

WP_049549711
1127
vvDAS KLIPIKS-G---L-SPEKYGGYARPTIAYSV-LVIAD--IE--KGKTKKLKRIKEMVGITIQD KKKFEA
1190

WP_007896501
1121
--NSD KLIE----RKKGW-DPKKYGGFDSPNTAYSI-FVVAK--VA--KRKAQKLKTVKEIVGITIME QAEYEK
1182

EFR44625
1073
--NSD KLIE----RKKGW-DPKKYGGFDSPNTAYSI-FVVAK--VA--KRKAQKLKTVKEIVGITIME QAEYEK
1134

WP_002897477
1119
--NSD KLIPRKT-KDILW-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KAAFEE
1183

WP_002906454
1124
vvDAS KLIPIKS-S---L-SPEKYGGYARPTIAYSV-LVIAD--IEkgKGKAKKLKRIKEIVGITIQD KKKFES
1189

WP_009729476
1120
--NSD KLIPRKT-KDILW-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KDAFEK
1184

COR24647
1110
--GSD KLIARKT-KNNYL-STQKYGGFDSPTVAYSI-MFVAD--IE--KGKSKRLKTVKEMIGITIME RSRFES
1174

WP_000066813
1124
--NSD KLIPRKT-KEILW-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KATFEK
1188

WP_009754323
1120
--NSD KLIPRKT-KDILW-DTTKYGGFDSPVIAYSI-LLIAD--IE--KGKAKKLKTVKTLVGITIME KAAFEK
1184

WP_044674937
1113
--DSD KLIPRKT-EKFYL-DTKKYGGFDSPTIAYSV-LLIAD--IE--KGKAKKLKRVKELIGITIME RMAFEK
1177

WP_044676715
1115
--DSD KLIPRKT-EKFYL-DTKKYGGFDSPTIAYSV-LLIAD--IE--KGKAKKLKRVKELIGITIME RMAFEK
1179

WP_044680361
1115
--DSD KLIPRKT-EKFYL-DTKKYGGFDSPTIAYSV-LLIAD--IE--KGKAKKLKRVKELIGITIME RMAFEK
1179

WP_044681799
1113
--DSD KLIPRKT-EKFYL-DTKKYGGFDSPTIAYSV-LLIAD--IE--KGKAKKLKRVKELIGITIME RMAFEK
1177

WP_049533112
1123
--DSS ENLVGVK-RNL---DPKKYGGYAGISNSYAV-LVKAI--IE--KGVKKKETMVLEFQGISILD RITFEK
1185

WP_029090905
1062
--SSS KTIP----LKKHL-DTAIYGGYTAVNYASYA---LIQ--FK----KGRKLK--REIIGIPLAV QTRIDN
1117

WP_006506696
1085
haDKG AVVP---vNKNRS-DVHKYGGFSG--LQYTI----VA--IEgqKKKGKKTELVKKISGVPLHL KAASIN
1149

AIT42264
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_034440723
1093
k-KTE KRIP----IKNNL-DPNIYGGYIEEKMAYYI----AInyLE--NGKTKK-----AIVGISIKD KKDFEG
1149

AKQ21048
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

WP_004636532
1093
--DSS KLIP----VKEGM-DPQKYGGLSQVSEAFAV-VIT----HE--KGKKKQLK--SDLISIPIVD QKAYEQ
1150

WP_002364836
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPIVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_016631044
1050
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1107

EMS75795
835
--KPD KLIQ----RKAGW-DVSKYGGFGSPVVAYAV-AFI----YE--KGKAR--KKAKAIEGITIMK QSLFEQ
892

WP_002373311
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_002378009
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPIVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_002407324
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPIVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_002413717
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_010775580
1101
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1158

WP_010818269
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPIVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_010824395
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_016622645
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPIVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_033624816
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_033625576
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTKFEQ
1156

WP_033789179
1099
--PSN KLIP----VKNGL-DPQKYGGFDSPVVAYTV-LF--T--HE--KGK-KPL-IKQEILGITIME KTRFEQ
1156

WP_002310644
1101
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1158

WP_002312694
1102
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_002314015
1102
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_002320716
1102
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_002330729
1101
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1158

WP_002335161
1102
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_002345439
1102
--DSS KLLP----RKNNW-DPTKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_034867970
1092
--KPD KLIE----RKNNW-DVTKYGGFGSPVIAYAI-AFV----YA--KGKTQ--KKTRAIEGITIME QAAFEK
1149

WP_047937432
1102
--DSS KLLP----RKNNW-DPAKYGGLGSPNVAYTV-AFT----YE--KGKAR--KRTNALEGITIME REAFEQ
1159

WP_010720994
1092
--KPD KLIE----RKNNW-DVTKYGGFGSPVIAYAI-AFV----YA--KGKTQ--KKTKAIEGITIME QAAFEK
1149

WP_010737004
1092
--KPD KLIE----RKNNW-DVTKYGGFGSPVIAYAI-AFV----YA--KGKTQ--KKTRAIEGITIME QAAFEK
1149

WP_034700478
1092
--KPD KLIE----RKNNW-DVTKYGGFGSPVIAYAI-AFV----YA--KGKTQ--KKTRAIEGITIME QAAFEK
1149

WP_007209003
1090
--ESQ KLIR----RKQQW-NTKKYGGFDSPVVAYAI---LLS--FD--KGK-RKARSFK-IVGITIQD RESFEG
1147

WP_023519017
1086
--NPE KLIP----RKASL-DPLKYGGYGSPLVAYTV-IFI----FE--KGKQK--KVTKGIEGITVME QLRFEQ
1143

WP_010770040
1097
--DSD KLIS----RKTNW-SPKLYGGFDSPQVAYSV-II--T--YE--KGK-KKVRA-KAIVGITIME QSLFKK
1154

WP_048604708
1094
--DSD KLIS----RKKEW-DTTKYGGFDSPNVAYSV-VI--R--YE--KGK-TRKLV-KTIVGITIME RAAFEK
1151

WP_010750235
1095
--KPD KLIK----RKNNW-DVTKYGGFGSPVVAYAV-VFT----YE--KGKNH--KKAKAIEGITIME QALFEK
1152

AII16583
1154
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1215

WP_029073316
1100
hsEKG AKVP---vNKLRS-NVHKYGGFEG--LKYSI----VA--IKgkKKKGKKIIDVNKLVGIPLMY KNVDDE
1164

WP_031589969
1100
nsDKD ATVP---vNKYRS-NVNKYGGFSG--VNSFI----VA--IKgkKKKGKKVIEVNKLTGIPLMY KNADEE
1164

KDA45870
1079
--DSG KLLP----RKEGL-DPVKYGGYAKAVESYAV-LITAD-eVK--KGKTKKVKT---LVNIPIID SKKYEA
1138

WP_039099354
1098
k-ASG QLIPAKQdRPTAL-----YGGYSGKTVAYMC---IVR--IKnkKGDLYKVCGVETSWLAQLKQ KKAFLK
1170

AKP02966
1119
k---- KLIA----QKKDM-DPNIYGGFSGDNKSSIT---IVK--ID-----NNKIKPVA--IPIRLIN ----DK
1172

WP_010991369
1096
--NSS KLIP----RKTNW-DPMKYGGLDSPNMAYAV-VI--E--YA--KGK-NKLVFEKKIIRVTIME RKAFEK
1154

WP_033838504
1096
--NSS KLIS----RKTNW-DPMKYGGLDSPNMAYAV-VI--E--YA--KGK-NKLVFEKKIIRVTIME RKAFEK
1154

EHN60060
1099
--NSS KLIS----RKTNW-DPMKYGGLDSPNMAYAV-VI--E--YA--KGK-NKLVFEKKIIRVTIME RKAFEK
1157

EFR89594
865
--NSS KLIP----RKTNW-DPMKYGGLDSPNMAYAV-VI--E--YA--KGK-NKLVFEKKIIRVTIME RKAFEK
923

WP_038409211
1096
--NSS KLIS----RKADW-NPIKYGGFDGSNMAYSI-VI--E--YE--KRK-KKTVIKKELIQINIME RVAFEK
1154

EFR95520
715
--NSS KLIS----RKADW-NPIKYGGFDGSNMAYSI-VI--E--YE--KRK-KKTVIKKELIQINIME RVAFEK
773

WP_003723650
1096
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKIVIEKKLIQINIME RKMFEK
1154

WP_003727705
1096
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKIVIEKKLIQINIME RKMFEK
1154

WP_003730785
1096
--NSS KLIP----RKENW-DPVKYGGLDSPNMAYAV-II--E--HA--KGK-KKIVIEKKLIQINIME RKMFEK
1154

WP_003733029
1096
--KSN KLIP----RKKDW-DPIKYGGFDGSKMAYAI-II--E--YE--KQK-RKVRIEKKLIQINIME REAFEK
1154

WP_003739838
1096
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKVVFEKKIIRITIME RKAFEK
1154

WP_014601172
1096
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKLIFEKKIIRITIME RKMFEK
1154

WP_023548323
1096
--DSS KLIP----KKTNL-NPIKYGGFEGSNMAYAI-II--E--HE--KRK-KKVTIEKKLIQINIME RKAFEK
1154

WP_031665337
1096
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KRIVIEKKLIQINIME RKMFEK
1154

WP_031669209
1096
--KSN KLIP----RKKDW-DPIKYGGFDGSKMAYAI-II--E--YE--KQK-RKVRIEKKLIQINIME REAFEK
1154

WP_033920898
1096
--DSS KLIP----KKTNL-NPIKYGGFEGSNMAYAI-II--E--HE--KRK-KKVTIEKKLIQINIME RKAFEK
1154

AKI42028
1099
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKLIFEKKIIRITIME RKMFEK
1157

AKI50529
1099
--DSS KLIP----KKTNL-NPIKYGGFEGSNMAYAI-II--E--HE--KRK-KKVTIEKKLIQINIME RKAFEK
1157

EFR83390
544
--NSS KLIP----RKENW-DPMKYGGLDSPNMAYAV-II--E--HA--KGK-KKIVIEKKLIQINIME RKMFEK
602

WP_046323366
1096
--NSS KLIP----RKADW-DPIKYGGFDGSNMAYAI-VI--E--HE--KRK-KKTVIKKELIQINIME RTAFEK
1154

AKE81011
1131
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1192

CUO82355
1089
hsAKG AVIP---vNKNRK-DVNKYGGFSG--LQYVI----AA--IEgtKKKGKKLVKVRKLSGIPLYL KQADIK
1153

WP_033162887
1090
hsEKG ATVP---1NKYRA-DVHKYGGFGN--VOSII----VA--IEgkKKKGKKLIDVRKLTSIPLHL KNAPVE
1154

AGZ01981
1148
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1209

AKA60242
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

AKS40380
1115
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1176

4UN5_B
1119
--NSD KLIA----RKKDW-DPKKYGGFDSPTVAYSV-LVVAK--VE--KGKSKKLKSVKELLGITIME RSSFEK
1180

WP_010922251
1177

embedded image

1239

WP_039695303
1186
NPV---EFLE---NKGYHN--I-REDKLIK--LPKYSLFE---FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA
1248

WP_045635197
1184
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS
1246

5AXW_A
913
KPYrfdVYLD---NGVYKFvtV-KNLDVIK----KENYYE---VNSKAYEEAKK -KKISNQAEFIASFYNNDLIKIN
978

WP_009880683
861
DPV---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
923

WP_010922251
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_011054416
1177
DPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_011284745
1177
NPI---DFLE---AKGYKE--V-RKDLIVK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_011285506
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_011527619
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_012560673
1177
DPV---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_014407541
1176
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1238

WP_020905136
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_023080005
1176
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1238

WP_023610282
1176
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1238

WP_030125963
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_030126706
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_031488318
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_032460140
1177
DPV---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_032461047
1177
DPV---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_032462016
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_032462936
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_032464890
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_033888930
1002
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1064

WP_038431314
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_038432938
1176
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1238

WP_038434062
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

BAQ51233
1088
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1150

KGE60162
352
DPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
414

KGE60856
115
DPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
177

WP_002989955
1177
NPI---DFLE---AKGYKE--V-RKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_003030002
1159
HPV---DFLE---QRGYRN--V-RLEKIIK--LPKYSLFE---LENKRRRLLAS ARELQKGNELVIPQRFTTLLYHS
1221

WP_003065552
1187
NPV---EFLE---NKGYHN--I-REDKLIK--LPKYSLFE---FEGGKRRLLAS ASELQKGNEMVIPGHLVKLLYHA
1249

WP_001040076
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040078
1186
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1248

WP_001040080
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040081
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGETIDRLQKGNELALPTQFMKFLYLA
1240

WP_001040083
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040085
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040087
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040088
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040089
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040090
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040091
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040092
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040094
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040095
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040096
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040097
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS ADELQKGNELALPTQFMKFLYLA
1240

WP_001040098
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040099
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040100
1178
NPS---AFLE---SKGYLD--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040104
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040105
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_001040106
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040107
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040108
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040109
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_001040110
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_015058523
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_017643650
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS ADELQKGNELALPTQFMKFLYLA
1240

WP_017647151
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_017648376
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_017649527
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_017771611
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_017771984
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

CFQ25032
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

CFV16040
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

KLJ37842
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

KLJ72361
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

KLL20707
1192
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1254

KLL42645
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_047207273
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_047209694
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_050198062
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_050201642
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_050204027
1178
NPS---AFLE---SKGYLN--I-RDDKLMI--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

WP_050881965
1178
NLS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_050886065
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

AHN30376
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA
1240

EAO78426
1178
NPS---AFLE---SKGYLN--I-RADKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

CCW42055
1178
NPS---AFLE---SKGYLN--I-RTDKLII--LPKYSLFE---LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA
1240

WP_003041502
1186
DKR---AFLL---GKGYKD--I-K--KIIE--LPKYSLFE---LKDGSRRMLAS RGEIHKGNELFVPQKFTTLLYHA
1253

WP_037593752
1160
NPV---DFLE---QRGYRN--V-RLEKIIK--LPKYSLFE---LENKRRRLLAS ARELQKGNELVIPQRFTTLLYHS
1222

WP_049516684
1160
HPV---DFLE---QRGYRN--V-RLEKIIK--LPKYSLFE---LENKRRRLLAS ARELQKGNELVIPQRFTTLLYHS
1222

GAD46167
1159
NPV---DFLE---QRGYRN--V-RLEKIIK--LPKYSLFE---LENKRRRLLAS ARELQKGNELVIPQRFTTLLYHS
1221

WP_018363470
1191
NPV---EFLK---NKGYQN--V-QEDKLMK--LPKYSLFE---FEGGRRRLLAS ATELQKGNEIMLSAHLVALLYHA
1253

WP_003043819
1186
DPI---GFLE---AKGYKD--I-KKELIFK--LPKYSLFE---LENGRRRMLAS --ELQKANELVLPQHLVRLLYYT
1248

WP_006269658
1159
NPV---DFLE---QRGYRN--V-RLEKIIK--LPKYSLFE---LENKRRRLLAS AKELQKGNELVIPQRFTTLLYHS
1221

WP_048800889
1179
NPI---MFLE---SKGYRN--I-QKDKLIK--LPKYSLFE---FEGGRRRLLAS AVELQKGNEMVLPQYLNNLLYHA
1241

WP_012767106
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_014612333
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_015017095
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_015057649
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_048327215
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_049519324
1178
NPL---KFIE---DKGYGN--V-QIDKCIK--LPKYSLFE---FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY--
1245

WP_012515931
1157
NPV---VFLE---ARGYRE--I-QEHLIIK--LPKYSLFE---LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA
1219

WP_021320964
1157
NPV---VFLE---AKGYRE--I-QEHLIIK--LPKYSLFE---LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA
1219

WP_037581760
1157
NPV---VFLE---AKGYRE--I-QEHLIIK--LPKYSLFE---LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA
1219

WP_004232481
1189
NPV---SFLE---KKGYHN--V-QEDKLIK--LPKYSLFE---FEGGRRRLLAS ATELQKGNEVVLPQYMVNLLYHS
1251

WP_009854540
1184
NPV---EFLE---NKGYHN--I-REDKLIK--LPKYSLFE---FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA
1246

WP_012962174
1185
NPV---VFLE---KKGYQN--V-QEDNLIK--LPKYSLFE---FEGGRRRLLAS ASELQKGNEVVLSRHLVELLYHA
1247

WP_039695303
1186
NPV---EFLE---NKGYHN--I-REDKLIK--LPKYSLFE---FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA
1248

WP_014334983
1189
NPV---SFLE---KKGYHN--V-QEDKLIK--LPKYSLFE---FEGGRRRLLAS ATELQKGNEVMLPAHLVELLYHA
1251

WP_003099269
1177
DPI---AFLE---KKGYQD--I-QTSSIIK--LPKYSLFE---LENGRKRLLAS --ELQKGNELALPNKYVKFLYLA
1239

AHY15608
1177
DPI---AFLE---KKGYQD--I-QTSSIIK--LPKYSLFE---LENGRKRLLAS --ELQKGNELALPNKYVKFLYLA
1239

AHY17476
1177
DPI---AFLE---KKGYQD--I-QTSSIIK--LPKYSLFE---LENGRKRLLAS --ELQKGNELALPNKYVKFLYLA
1239

ESR09100
9
DPI---AFLE---KKGYQD--I-QTSSIIK--LPKYSLFE---LENGRKRLLAS -KELQKGNELALPNKYVKFLYLA
71

AGM98575
1177
DPI---AFLE---KKGYQD--I-QTSSIIK--LPKYSLFE---LENGRKRLLAS --ELQKGNELALPNKYVKFLYLA
1239

ALF27331
1159
NPV---AFLE---RKGYRN--V-QEENIVK--LPKYSLFE---LENGRRRLLAS ARELQKGNEIVLPNHLGTMLYHA
1221

WP_018372492
1168
EPEr---FLA---QKGFER--V-EKT--IK--LPKYSLFE---MEKGRRRLLAS SGELQKGNQVLLPEHLIRLLSYA
1228

WP_045618028
1189
NPI---AYLE---ECGYKN--I-NPNLIIK--LPKYSLFE---FNNGQRRLLAS SIELQKGNELIVPYHFTALLYHA
1251

WP_045635197
1184
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS
1246

WP_002263549
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002263887
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002264920
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002269043
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002269448
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002271977
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002272766
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002273241
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002275430
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002276448
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002277050
1167
NPV---KFLK---DKGYQQ--I-EKNNFVK--LPKYTLVD---IGNGIKRLWAS SKEVHKGNOLVVSKKSQDLLYHA
1229

WP_002277364
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002279025
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002279859
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002280230
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002281696
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002282247
1167
NPV---KFLK---DKGYQQ--I-EKNNFVK--LPKYTLVD---IGNGIKRLWAS SKEVHKGNQLVVSKKSQDLLYHA
1229

WP_002282906
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002283846
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002287255
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002288990
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002289641
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002290427
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002295753
1159
DPI---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002296423
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002304487
1173
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLETLLYHA
1235

WP_002305844
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002307203
1159
DPI---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002310390
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_002352408
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPDHLGTLLYHA
1221

WP_012997688
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_014677909
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019312892
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019313659
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019314093
1159
DPI---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019315370
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019803776
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_019805234
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_024783594
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_024784288
1167
NPV---KFLK---DKGYQQ--I-EKNNFVK--LPKYTLVD---IGNGIKRLWAS SKEVHKGNQLVVSKKSQDLLYHA
1229

WP_024784666
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_024784894
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_024786433
1167
NPV---KFLK---DKGYQQ--I-EKNNFVK--LPKYTLVD---IGNGIKRLWAS SKEVHKGNQLVVSKKSQDLLYHA
1229

WP_049473442
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

WP_049474547
1159
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1221

EMC03581
1152
DPV---AFLE---RKGYRN--V-QEENIIK--LPKYSLFK---LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA
1214

WP_000428612
1187
SPI---AFLE---NKGYHN--V-RKENILC--LPKYSLFE---LKNGRRRMLAS AKELQKGNEIVLPVHLTTLLYHA
1249

WP_000428613
1185
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS
1247

WP_049523028
1180
NPV---AFLE---GKGYQN--V-VEENIIR--LPKYSLFE---LENGRRRMLAS AKELQKGNEMVLPSYLIALLYHA
1242

WP_003107102
1146
DRI---TFLE---KKGYQD--I-QESLIIK--LPKFSLFE---LENGRKRLLAS --ELQKGNELSLPNKYIQFLYLA
1208

WP_054279288
1179
NPI---AFLE---SKGYHD--I-QEHLMIT--LPKYSLFE---LENGRRRLLAS --ELQKGNEMVLPQHLVTFLYRV
1241

WP_049531101
1189
NPT---AYLE---EYGYKN--I-NPNLIIK--LPKYSLFK---ENDGORRLLAS SIELQKGNELILPYHFTTLLYHA
1251

WP_049538452
1189
NPI---AYLE---ECGYKN--I-NPNLIIK--LPKYSLFE---FNGGORRLLAS SIELQKGNELILPYHFTALLYHT
1251

WP_049549711
1191
NPI---AYLE---ECGYKN--I-NPNLIIK--LPKYSLFE---FNGGQRRLLAS SIELQKGNELILPYHFTALLYHA
1253

WP_007896501
1183
DNI---AFLE---KKGYQD--I-QEKLLIK--LPKYSLFE---LENGRRRLLAS --EFQKGNELALSGKYMKFLYLA
1245

EFR44625
1135
DNI---AFLE---KKGYQD--I-QEKLLIK--LPKYSLFE---LENGRRRLLAS --EFQKGNELALSGKYMKFLYLA
1197

WP_002897477
1184
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LENGRRRLLAS AKELQKGNEIVLPVCLTTLLYHS
1246

WP_002906454
1190
NPV---TYLE---ECGYKN--I-NSNLIIK--LPKYSLFE---ENDGORRLLAS SIELQKGNELILPYHLTALLYHA
1252

WP_009729476
1185
NPI---AFLE---NKGYHN--V-CKENILC--LPKYSLFE---LENGRRRLLAS AKELQKCNEIVLPVYLITLLYHS
1247

COR24647
1175
NSV---TFLE---EKGYRN--I-RENTIIK--FPKYSLFE---LENGRRRLLAS AIELQKGNEMFLPQQFVNLLYHA
1237

WP_000066813
1189
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LESGRRRMLAS AKELQKGNEIVLPVYLTTLLYHS
1251

WP_009754323
1185
NPI---TFLE---NKGYHN--V-RKENILC--LPKYSLFE---LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS
1247

WP_044674937
1178
NPI---EFLE---HKGYKN--I-LEKNIIK--LPKYSLFE---LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS
1240

WP_044676715
1180
NPI---EFLE---HKGYKN--I-LEKNIIK--LPKYSLFE---LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS
1242

WP_044680361
1180
NPI---EFLE---HKGYKN--I-LEKNIIK--LPKYSLFE---LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS
1242

WP_044681799
1178
NPI---EFLE---HKGYKN--I-LEKNIIK--LPKYSLFE---LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS
1240

WP_049533112
1186
DKR---AFLL---GKGYKD--I-K--KIIE--LPKYSLFE---LKDGSRRMLAS RGEIHKGNELFVPQKFTTLLYHA
1253

WP_029090905
1118
SETslqAYIA---EQIKSE--VeILN----grILKYQLIS----NNGNRLYIAG -SERHNARQLIVSDEAAKVIWLI
1181

WP_006506696
1150
EKI---NYIE--eKEGLSD--VrIIK---Dn-IPVNOMIEm----DGGEYLLTS --EYVNARQLVLNEKQCALIADI
1211

AIT42264
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_034440723
1150
QTT---EYLG---KIGFNK--ASIIN---S--FKNYTLFE---LENGSRRMIVG KGELQKGNQMYLPQNLLEFVYHL
1217

AKQ21048
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

WP_004636532
1151
HPT---AYLE---EAGYNN--P-TV--LHE--LFKYQLFE---LEDGSRRMIAS AKEFQKGNQMVLPLELVELLYHA
1211

WP_002364836
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_016631044
1108
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1168

EMS75795
893
DPI---GFLS---NKGYSN--V-TKF--IK--LSKYTLYE---LENGRRRMVAS -KEAQKANSFILPEKLVTLLYHA
953

WP_002373311
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_002378009
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYQ---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_002407324
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_002413717
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_010775580
1159
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLILLYHA
1219

WP_010818269
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_010824395
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNOMVLPEHLLTLLYHA
1217

WP_016622645
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_033624816
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPERLLTLLYHA
1217

WP_033625576
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_033789179
1157
NPI---LFLE---EKGFLR--P-RV--LMK--LPKYTLYE---FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA
1217

WP_002310644
1159
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA
1219

WP_002312694
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA
1220

WP_002314015
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSELLPEHLVTLLYHA
1220

WP_002320716
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSELLPEHLVTLLYHA
1220

WP_002330729
1159
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSELLPEHLVTLLYHA
1219

WP_002335161
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA
1220

WP_002345439
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSFLLPEHLVILLYHA
1220

WP_034867970
1150
DPT---TFLK---EKGFPQ--V-TEF--IK--LPKYTLFE---FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA
1210

WP_047937432
1160
SPV---LFLK---NKGYEQ--A-EIE--MK--LPKYALFE---LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA
1220

WP_010720994
1150
DPT---TFLK---DKGFPQ--V-TEF--IK--LPKYTLFE---FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA
1210

WP_010737004
1150
DPT---TFLK---EKGFPQ--V-TEF--IK--LPKYTLFE---FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA
1210

WP_034700478
1150
DPT---TFLK---DKGFPH--V-TEF--IK--LPKYTLFE---FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA
1210

WP_007209003
1148
NPIl---YLS---KKDYHN---pKVEAI----LPKYSLFE---FENGRRRMVAS -SETQKGNOLIIPGHLMELLYHS
1208

WP_023519017
1144
DPR---EFLK---TKGYEG--V-KQW--LI--LPKYILFE---AQGGYRRMIAS -QETQKANSLILPENLVTLLYHA
1204

WP_010770040
1155
DPV---SLLE---EKGYAN--P-EV--LIH--LPKYTLYE---LENGRRRLLAS ANEAQKGNQLVLPASLVTLLYHA
1215

WP_048604708
1152
NER---EFLK---NKGYQN--P-QI--CMK--LPKYSLYE---FDDGRRRLLAS AKEAQKGNQMVLPAHLVTFLYHA
1212

WP_010750235
1153
DPI---SFLI---EKGYSN--V-NQF--IK--LPKYTLFE---LANGORRMLAS -QELQKANSFILPEKLVTLLYHA
1213

AII16583
1216
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1278

WP_029073316
1165
TKI---NYIK--eSEGLEE--VKIIK---E--ILKNQLIEi----NGGLFYVTS --EIVNARQLILDENCTRIIDGI
1225

WP_031589969
1165
IKI---NYLK--qAEDLEE--VqIGK---E--ILKNQLIEk----DGGLYYIVA --EIINAKQLILNESQTKLVCEI
1225

KDA45870
1139
DPT---AYLA---SRGYTNvtNsFIL-------PKYSLLEd---PEGRRRYLAS -KEFQKANELILPQHLVELLYWV
1199

WP_039099354
1171
QKI-spQFTKv---KKQKGtiV-KVVEDFEv-IAPHILINqrfFDNGQELTLGS ----HNEQELILDKTAVKLLNGA
1241

AKP02966
1173
KTL--qNWLE---ENVKHKksIqIIK---Nn-VPIGQIIY------SKKVGLLS -REIANRQQLILPPEHSALLRIL
1237

WP_010991369
1155
DEK---AFLE---EQGYRQ--P-KV--LAK--LPKYTLYE---CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHA
1215

WP_033838504
1155
DEK---AFLE---EQGYRQ--P-KV--LAK--LPKYTLYE---CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHV
1215

EHN60060
1158
DEK---AFLE---EQGYRQ--P-KV--LAK--LPKYTLYE---CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHV
1218

EFR89594
924
DEK---AFLE---EQGYRQ--P-KV--LAK--LPKYTLYE---CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHA
984

WP_038409211
1155
DQK---AFLE---EKGYYS--P-KV--LTK--IPKYTLYE---CENGRRRMLGS ANEAQKGNQMVLPNHLMILLYHA
1215

EFR95520
774
DQK---AFLE---EKGYYS--P-KV--LTK--IPKYTLYE---CENGRRRMLGS ANEAQKGNQMVLPNHLMTLLYHA
834

WP_003723650
1155
DEE---AFLE---EKGYRH--P-KV--LTK--LPKYTLYE---CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA
1215

WP_003727705
1155
DEE---AFLE---EKGYHQ--P-KV--LTK--LPKYTLYE---CEKGRRRMLSS ANEAQKGNQLVLSNHLVSLLYHA
1215

WP_003730785
1155
DEE---AFLE---EKGYHQ--P-KV--LTK--LPKYTLYE---CEKGRRRMLSS ANEAQKGNQLVLSNHLVSLLYHA
1215

WP_003733029
1155
DEK---TFLE---EKGYHQ--P-KV--LIK--VPKYTLYE---CKNGRRRMLGS ANEAHKGNQMLLPNHLMALLYHA
1215

WP_003739838
1155
DEK---SFLE---KQGYRQ--P-KV--LTK--LPKYTLYE---CENGRRRMLAS ANEAQKGNQQVLKGOLITLLHHA
1215

WP_014601172
1155
DEE---AFLE---EKGYRH--P-KV--LTK--LPKYTLYE---CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA
1215

WP_023548323
1155
DEK---VFLE---GKGYHQ--P-KV--LTK--LPKYALYE---CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA
1215

WP_031665337
1155
DEE---AFLE---EKGYRH--P-KV--LTK--LPKYTLYE---CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA
1215

WP_031669209
1155
DEK---TFLE---EKGYHQ--P-KV--LIK--VPKYTLYE---CENGRRRMLGS ANEAHKGNQMLLPNHLMALLYHA
1215

WP_033920898
1155
DEK---VFLE---GKGYHQ--P-KV--LTK--LPKYALYE---CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA
1215

AKI42028
1158
DEE---AFLE---EKGYRH--P-KV--LTK--LPKYTLYE---CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA
1218

AKI50529
1158
DEK---VFLE---GKGYHQ--P-KV--LTK--LPKYALYE---CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA
1218

EFR83390
603
DEE---AFLE---EKGYRH--P-KV--LTK--LPKYTLYE---CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA
663

WP_046323366
1155
DOK---EFLE---GKGYRN--P-KV--ITK--IPKYTLYE---CENGRRRMLGS ANEAQKGNQMVLPNHLMTLLYHA
1215

AKE81011
1193
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1255

CUO82355
1154
EQI---EYVE--kEEKLSD--VKIIK---Nn-IPLNQLIEi----DGRQYLLTS --ECVNAMQLVLNEEQCKLIADI
1215

WP_033162887
1155
EQL---SYIAspeHEDLID--VrIVK---E--ILKNQLIEi----DGGLYYVTS --EYVTARQLSLNEQSCKLISEI
1217

AGZ01981
1210
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1272

AKA60242
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

AKS40380
1177
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1239

4UN5_B
1181
NPI---DFLE---AKGYKE--V-KKDLIIK--LPKYSLFE---LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA
1243

WP_010922251
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_039695303
1249
HRAD----NFNS-TEYLN--YVSEHKKEFEKVLSCVEDFANLYVDVE--KNLSKIR-A VAD-SM---DNFSIEE--
1308

WP_045635197
1247
KNVH----KLDE-PGHLE--YIQKHRNEFKDLLNLVSEFSQKYVLAD--ANLEKIK-S LYA-DN---EQADIEI--
1306

5AXW_A
979
GELYRVIgVNND1LNRIE---VNMIDITYREYLENMNDKRPPRIIKTiaSKTQSIK-K LYEvKSk--KHPQIIKkg
1056

WP_009880683
924
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
989

WP_010922251
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_011054416
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_011284745
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_011285506
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_011527619
1240
SHYEKLKgSPEDNEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_012560673
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_014407541
1239
SHYEKLKgSPEDNEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1304

WP_020905136
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_023080005
1239
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1304

WP_023610282
1239
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1304

WP_030125963
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_030126706
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_031488318
1240
SHYEKLKgSPEDnEQKQL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_032460140
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_032461047
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_032462016
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_032462936
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_032464890
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_033888930
1065
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1130

WP_038431314
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_038432938
1239
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1304

WP_038434062
1240
SHYEKLKgSPEDNEQKQL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

BAQ51233
1151
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1216

KGE60162
415
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
480

KGE60856
178
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
243

WP_002989955
1240
SHYEKLKgSPEDNEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_003030002
1222
YQIE----KNYE-PEHRE--YVEKHKDEFKELLEYISVFSRKYVLAD--NNLTKIE-M LFS-KN---KDAEVSS--
1281

WP_003065552
1250
QRIN----SENS-TKYLD--YVSAHKKEFEKVLSCVEDFANLYVDVE--KNLSKIR-A VAD-SM---DNFSIEE--
1309

WP_001040076
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDIFQIINDFSKRVILAD--ANLEKIN-R LYQ-DNk--ENIPVDE--
1306

WP_001040078
1249
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1314

WP_001040080
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040081
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040083
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040085
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040087
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040088
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040089
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040090
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040091
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040092
1241
SRYNESKgKPEEiEKKQE--FVNQHISYFDDILOLINDFSKRVILAD--ANLEKIN-K LYS-DNk--DNTPVDE--
1306

WP_001040094
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040095
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040096
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040097
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040098
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040099
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040100
1241
SRYNELKgKPEEEiQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_001040104
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040105
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040106
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040107
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040108
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040109
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_001040110
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYEDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_015058523
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYS-DNk--DNTPVDE--
1306

WP_017643650
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_017647151
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_017648376
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_017649527
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_017771611
1241
SRYNELKgKPEEiEQKQE--FVVOHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_017771984
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

CFQ25032
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

CFV16040
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

KLJ37842
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

KLJ72361
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

KLL20707
1255
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1320

KLL42645
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_047207273
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_047209694
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENIPVDE--
1306

WP_050198062
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_050201642
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_050204027
1241
SRYNELKgKPEEiEQKQE--FVVQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_050881965
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILOLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_050886065
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

AHN30376
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDESKRVILAD--ANLEKIN-K LYS-DNk--DNTPVDE--
1306

EAO78426
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

CCW42055
1241
SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQIINDFSNRVILAD--ANLEKIN-K LYQ-DNk--ENISVDE--
1306

WP_003041502
1254
KRIN----NPIN-KDHIE--YVKKHRDDFKELLNYVLEFNEKYVGAT--KNGERLK-E AVA-DF---DSKSNEE--
1313

WP_037593752
1223
YQIE----KNYE-PEHRE--YVEKHKDEFKELLEYISVFSRKYVLAD--NNLTKIE-M LFS-KN---KDAEVSS--
1282

WP_049516684
1223
YRIE----KDYE-PEHRE--YVEKHKDEFKELLEYISVFSRKYVLAD--NNLTKIE-M LFS-KN---KDAEVSS--
1282

GAD46167
1222
YQIE----KNYE-PEHRE--YVEKHKDEFKELLEYISVFSRKYVLAD--NNLTKIE-M LFS-KN---KDAEVSS--
1281

WP_018363470
1254
HRIG----NFNS-AEHLK--YVSEHKKEFEEVLSCVENFANVYVDVE--KNLSKIR-A AAD-SM---DNFSIEE--
1313

WP_003043819
1249
QNISATTgSNNLg-------YIEQHREEFKEIFEKIIDFSEKYILKN--KVNSNLK-S SFD-EQfavSDSIL--1-
1310

WP_006269658
1222
YRIE----KDYE-PEHRE--YVEKHKDEFKELLEYISVFSRKYVLAD--NNLTKIE-M LFS-KN---KDAEVSS--
1281

WP_048800889
1242
HRID----NSDN-SEHLK--YITEHKEEFGKLLSYIENFAKSYVDVD--KNLEKIQ-L AVE-KI---DSFSVKE--
1301

WP_012767106
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEi-
1308

WP_014612333
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEi-
1308

WP_015017095
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEi-
1308

WP_015057649
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEi-
1308

WP_048327215
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEi-
1308

WP_049519324
1246
-HAHKIESSKE--LEHEA--YILDHYNDLYQLLSYIERFASLYVDVE--KNISKVK-E LFS-NI---ESYSISEI-
1308

WP_012515931
1220
AHYHELTgSSEDVLRKKY--FVDRHLHYFDDIIQMINDFAERHILAS--SNLEKIN-H TYH-NN---SDLPVNEr-
1285

WP_021320964
1220
AHYHELTgSSEDVLRKKY--FVERHLHYFDDIIQMINDFAERHILAS--SNLEKIN-H TYH-NN---SDLPINEr-
1285

WP_037581760
1220
AHYHELTgSSEDVLRKKY--FVERHLHYFDDIIQMINDFAERHILAS--SNLEKIN-H TYH-NN---SDLPVNEr-
1285

WP_004232481
1252
QHVN----NSHK-PEHLN--YVKQHKDEFKDIFNLIISIARINILKP--KVVDNL--- -IN-EF---TEYGQED--
1308

WP_009854540
1247
HRAD----NFNS-TEYLN--YVSEHKKEFEKVLSCVEDFANLYVDVE--KNLSKIR-A VAD-SM---DNFSIEE--
1306

WP_012962174
1248
HRVN----SFNN-SEHLK--YVSEHKKEFGEVLSCVENFAKSYVDVE--KNLGKIR-A VAD-KI---DTFSIED--
1307

WP_039695303
1249
HRAD----NENS-TEYLN--YVSEHKKEFEKVLSCVEDFANLYVDVE--KNLSKIR-A VAD-SM---DNFSIEE--
1308

WP_014334983
1252
HRID----SFNS-TEHLK--YVSEHKKEFEKVLSCVENFSNLYVDVE--KNLSKVR-A AAE-SM---TNFSLEE--
1311

WP_003099269
1240
SHYTKFTgKEEDrEKKRS--YVESHLYYFDEIMQIIVEYSNRYILAD--SNLIKIQ-N LYK-EKd---NFSIEEq-
1305

AHY15608
1240
SHYTKFTgKEEDrEKKRS--YVESHLYYFXEVKSSF---------------------- ------------------
1273

AHY17476
1240
SHYTKFTgKEEDrEKKRS--YVESHLYXFX---------------------------- ------------------
1267

ESR09100
72
SHYTKFTgKEEDrEKKRS--YVESHLYYFDEIMQIIVEYSNRYILAD--SNLIKIQ-N LYK--Ek--DNFSIEEq-
137

AGM98575
1240
SHYTKFTgKEEDrEKKRS--YVESHLYYFDVRLSQVERVINVEF-------------- ------------------
1281

ALF27331
1222
KNIH----KVDE-PKHLD--YVKKHKDEFKELLDVVSNFSKKNILAE--SNLEKIE-E LYA-QN---NNKDITE--
1281

WP_018372492
1229
KKVDVLVKSKDD---DYD---LEEHRAEFAELLDCIKKENDMYILAS--SNMSKIE-E IYQ-KNi---DAPIEE--
1289

WP_045618028
1252
QRIN----KISE-PIHKQ--YVETHQSEFKELLTAIISLSKKYI-QK--PNVESL--- LQQ-AF---DQSDKDIyq
1310

WP_045635197
1247
KNVH----KLDE-PGHLE--YIQKHRNEFKDLLNLVSEFSQKYVLAD--ANLEKIK-S LYA-DN---EQADIEI--
1306

WP_002263549
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002263887
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002264920
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002269043
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002269448
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002271977
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002272766
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002273241
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002275430
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002276448
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002277050
1230
HHL-------DN-DYSNE--YVKNHYQQFDILFNEITSFSKKCKLGK--EHIQKIE-E AYSKER---DSASIEE--
1287

WP_002277364
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002279025
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-ON---NGEDLKE--
1281

WP_002279859
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002280230
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002281696
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002282247
1230
HHL-------DN-DYSNE--YVKNHYQQFDILFNEITSFSKKCKLGK--EHIQKIE-E AYSKER---DFASIEE--
1287

WP_002282906
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002283846
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002287255
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002288990
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002289641
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002290427
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002295753
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002296423
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002304487
1236
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-ON---NGEDLKE--
1295

WP_002305844
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002307203
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002310390
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_002352408
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_012997688
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_014677909
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019312892
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019313659
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019314093
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019315370
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019803776
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_019805234
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_024783594
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_024784288
1230
HHL-------DN-DYSNE--YVKNHYQQFDILFNEITSFSKKCKLGK--EHIQKIE-E AYSKER---DFASIEE--
1287

WP_024784666
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_024784894
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_024786433
1230
HHL-------DN-DYSNE--YVKNHYQQFDILFNEITSFSKKCKLGK--EHIQKIE-E AYSKER---DSASIEE--
1287

WP_049473442
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

WP_049474547
1222
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1281

EMC03581
1215
KNIH----KVDE-PKHLD--YVDKHKDEFKELLDVVSNFSKKYTLAE--GNLEKIK-E LYA-QN---NGEDLKE--
1274

WP_000428612
1250
KNIH----RLDE-PEHLE--YIQKHRNEFKGLLNLVSEFSQKYVLAD--ANLEKIK-N LYA-DN---EQADIEI--
1309

WP_000428613
1248
KNVH----KLDE-PEHLE--YIQKHRNEFKDLLNLVSEFSQKYVLAD--ANLEKIQ-N LYA-DN---EQADIEI--
1307

WP_049523028
1243
KRIQ----KKDE-PEHLE--YIKQHHSEFNDLLNFVSEFSQKYVLAE--SNLEKIK-N LYI-DN---EQTNMEE--
1302

WP_003107102
1209
SRYTSFSgKEEDrEKHRH--FVESHLHYFDEIKDIIADFSRRYILAD--ANLEKIL-T LYN-EKn---QFSIEEq-
1274

WP_054279288
1242
SKRDK--gTQSEnME-----YISNHKEKFIEIFHYIIRYAEKNVIKP--KVIERLN-D TFNqKF---NDSDLTE1-
1303

WP_049531101
1252
QRIN----KISE-PIHKQ--YVETHOSEFEELLTTIISLSKKYI-QK--PIVESL--- LQQ-AF---EQADKDIyq
1310

WP_049538452
1252
QRIN----KISE-PIHKQ--YVEAHQNEFKELLTTIISLSKKYI-QK--PNVESL--- LQQ-AF---EQADKDIyq
1310

WP_049549711
1254
QRIN----KFSE-PIHKQ--YVEAHQNEFKELLTIIISLSKKYI-QK--PNVESL--- LHQ-AF---EQADNDIyq
1312

WP_007896501
1246
SRYDKLSSKIESeQQKKL--FVEQHLHYFDEILDIVVKHATCYIKAE--NNLKKII-S LYK-KK---EAYSINEq-
1311

EFR44625
1198
SRYDKLSSKIESeQQKKL--FVEQHLHYFDEILDIVVKHATCYIKAE--NNLKKII-S LYK-KK---EAYSINEq-
1263

WP_002897477
1247
KNLH----KLDE-PEHLE--YIQKHRNEFKDLLNLVSEFSQKYILAE--ANLEKIK-D LYA-DN---EQADIEI--
1306

WP_002906454
1253
QRIN----KISE-PIHKQ--YVEAHQNEFKELLTTIISLSKKYI-QK--PNVELL--- LQQ-AF---DQADKDIyq
1311

WP_009729476
1248
KNVH----KLDE-PGHLE--YIQKHRNEFKDLLNLVSEFSQKYVLAD--ANLEKIK-N LYA-DN---EQADIEI--
1307

CQR24647
1238
QHAN----KEDS----VI--YLEKHRHELSELFHHIIGVSEKTILKP--KVEMTLN-E AFE-KHf--EFDEVSE--
1295

WP_000066813
1252
KNVH----KLDE-PEHLE--YIQKHRYEFKDLLNLVSEFSQKYVLAD--ANLEKIK-N LYA-DN---EQADIEI--
1311

WP_009754323
1248
KNVH----KLDE-PEHLE--YIQKHRYEFKDLLNLVSEFSQKYVLAE--ANLEKIK-S LYV-DN---EQADIEI--
1307

WP_044674937
1241
SNIH----KITE-PIHLN--YVNKNKHEFKELLRHISDFSTRYILAQ--DRLSKIE-E LYD-KN---DGDDISD--
1300

WP_044676715
1243
SNIH----KITE-PIHLN--YVNKNKHEFKELLRHISDFSTRYILAQ--DRLSKIE-E LYD-KN---DGDDISD--
1302

WP_044680361
1243
SNIH----KITE-PIHLN--YVNKNKHEFKELLRHISDFSTRYILAQ--DRLSKIE-E LYD-KN---DGDDISD--
1302

WP_044681799
1241
SNIH----KITE-PIHLN--YVNKNKHEFKELLRHISDFSTRYILAQ--DRLSKIE-E LYD-KN---DGDDISD--
1300

WP_049533112
1254
KRIN----NPIN-KDHIE--YVKKHRDDFKELLNYVLEFNEKYVGAT--KNGERLK-E AVA-DF---DSKSNEE--
1313

WP_029090905
1182
STKQA-----DE-AMFLKyyRLEHLEAVFEEL---IRKQAADYQIFE--KLIKKIEvN FYS----c----TYNEk-
1240

WP_006506696
1212
YNAIYKQ-DYDNIDDILMi-----------QLYIELTNKMKVLYPAY-rGIAEKFE-S YVV----i----SKEEk-
1268

AIT42264
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_034440723
1218
KHYNE-----DE--TSHK--FIVEHKAYFDELLNYIVEFANKYLELE--NSIEKIK-D LYH-----gKGPDVEEke
1276

AKQ21048
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

WP_004636532
1212
NRYDKVK-----fPDSIE--YVHDNLAKFDDLLEYVIDESNKYINAD--KNVQKIQ-K IYK-EH---GTEDVEL--
1271

WP_002364836
1218
KQCLL----PNQ-SESLA--YVEQHQPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_016631044
1169
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1228

EMS75795
954
QHYDEIAhKESF-----D--YVNDHLSEFREILDQVIDFSNRYTIAA--KNTEKIA-E LFE-QN---QESTVQS--
1013

WP_002373311
1218
KOCLL----PNQ-SESLA--YVEQHQPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_002378009
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_002407324
1218
KQCLL----PNQ-SESLA--YVEQHQPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_002413717
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_010775580
1220
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVOQIV-K LFE-AN---QTADVKE--
1279

WP_010818269
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_010824395
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_016622645
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_033624816
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_033625576
1218
KQCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-TN---QTADVKE--
1277

WP_033789179
1218
KOCLL----PNQ-SESLA--YVEQHOPEFQEILERVVDFAEVHTLAK--SKVQQIV-K LFE-AN---QTADVKE--
1277

WP_002310644
1220
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1279

WP_002312694
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_002314015
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_002320716
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_002330729
1220
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1279

WP_002335161
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_002345439
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_034867970
1211
QHYDKITyQESF-----D--YVNTHLSDFSAILTEVLAFAEKYTLAD--KNIERIQ-E LYE-EN---KYGETSM--
1270

WP_047937432
1221
KQYDEIShKESF-----D--YVNEHHKEFSEVFARVLEFAGKYTLAE--KNIEKLE-K IYK-EN---QTDDLAK--
1280

WP_010720994
1211
QHYDKITyQESF-----D--YVNTHLSDFSAILTEVLAFAEKYTLAD--KNIERIQ-E LYE-EN---KYGEISM--
1270

WP_010737004
1211
QHYDKITyQESF-----D--YVNTHLSDFSAILTEVLAFAEKYTLAD--KNIERIQ-E LYE-EN---KYGETSM--
1270

WP_034700478
1211
QHYDKITyQESF-----D--YVNTHLSDFSAILTEVLAFAEKYTLAD--KNIERIQ-E LYE-EN---KYGEISM--
1270

WP_007209003
1209
KKIIN--gKNSD---SVS--YIQNNKEKFREIFEYIVDFSSKYISAD--ANLNKIE-K IFE-NNfh----KASEqe
1269

WP_023519017
1205
RHYDEINhKVSF-----D--YVNAHKEGENDIFDFISDFGVRYILAP--QHLEKIK-V AYE-KN---KEVDLKE--
1264

WP_010770040
1216
KOVDE-----DS-GKSEE--YVREHRAEFAEILNYVQAFSETKILAN--KNLQTIL-K LYE-EN---KEADIKE--
1274

WP_048604708
1213
KHCNE-----KP-D-SLK--YVTEHQSGFSEIMAHVKDFAEKYTLVD--KNLEKIL-S LYA-KN---MDSEVKE--
1270

WP_010750235
1214
NHYDEIAyKDSY-----D--YVNEHFSNFQDILDKVIIFAEKYTSAP--QKLNQII-A TYE-KN---QEADRKI--
1273

AII16583
1279
SHYEKLKgSPEDNEQKQL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1344

WP_029073316
1226
YKAMKYK-NYSE1SQEEIm-----------NVYDIFVEKLKLYYPTY-KNIATNFE-N FEN----1----SDEEk-
1282

WP_031589969
1226
YKAMKYK-NYDNIDSEKII-----------DLYRLLINKMELYYPEYrkQLVKKFE-D LKV----i----SIEEk-
1283

KDA45870
1200
NAKDG--------EQKLE-----DHKAEFKELFDKIMEFADKYVVAP--KNSEKIR-R LYE-ENq-----DATPme
1253

WP_039099354
1242
LPLTQ-----SEeLAEQV----------YDEILDQVMHYFPLYDTNQfrAKLSAGKaA DGN-KMv-----QVGQqv
1306

AKP02966
1238
QIPDE-----DpDQILAf----YDKNILVEILQELITKMKKFYPFY--KNEQEFLaS FNQ--------ATTSEk--
1296

WP_010991369
1216
ANCEV-----SD-GKSLD--YIESNREMFAELLAHVSEFAKRYTLAE--ANLNKIN-Q LFE-QN---KEGDIKA--
1274

WP_033838504
1216
ANCEV-----SD-GKSLD--YIESNREMFAELLAHVSEFAKRYTLAE--ANLNKIN-Q LFE-QN---KEGDIKA--
1274

EHN60060
1219
ANCEV-----SD-GKSLD--YIESNREMFAELLAHVSEFAKRYTLAE--ANLNKIN-Q LFE-QN---KEGDIKA--
1277

EFR89594
985
ANCEV-----SD-GKSLD--YIESNREMFAELLAHVSEFAKRYTLAE--ANLNKIN-Q LFE-QN---KEGDIKA--
1043

WP_038409211
1216
KNCEA-----ND-GESLA--YIEMHREMFAELLAYISEFAKRYTLAN--DRLEKIN-M FFE-QN---KKGDIKV--
1274

EFR95520
835
KNCEA-----ND-GESLA--YIEMHREMFAELLAYISEFAKRYTLAN--DRLEKIN-M FFE-QN---KKGDIKV--
893

WP_003723650
1216
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN-N LFE-QN---KEGDIKA--
1274

WP_003727705
1216
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATKYTLAD--ANLSKIN-N LFE-QN---KEGDIKA--
1274

WP_003730785
1216
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATKYTLAD--ANLSKIN-N LFE-QN---KEGDIKA--
1274

WP_003733029
1216
EKYEA-----ID-GESLA--YIEVHRALFDELLAYISEFARKYTLSN--DRLDEIN-M LYE-RN---KDGDVKS--
1274

WP_003739838
1216
KNCEA-----SD-GKSLD--YIESNREMFGELLAHVSEFAKRYTLAD--ANLSKIN-Q LFE-QN---KDNDIKV--
1274

WP_014601172
1216
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN-N LFE-QN---KEGDIQA--
1274

WP_023548323
1216
EKREA-----ID-GESLA--YIEAHKAVFGELLAHISEFARKYTLAN--DKLDEIN-M LYE-RN---KDGDVKS--
1274

WP_031665337
1216
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN-N LFE-QN---KEGDIKA--
1274

WP_031669209
1216
EKYEA-----ID-GESLA--YIEVHRALFDELLAYISEFARKYTLSN--DRLDEIN-M LYE-RN---KDGDVKS--
1274

WP_033920898
1216
EKREA-----ID-GESLA--YIEAHKAVFGELLAHISEFARKYTLAN--DKLDEIN-M LYE-RN---KDGDVKS--
1274

AKI42028
1219
KNCEA-----SD-GKSLK--YIEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN-N LFE-QN---KEGDIQA--
1277

AKI50529
1219
EKREA-----ID-GESLA--YIEAHKAVFGELLAHISEFARKYTLAN--DKLDEIN-M LYE-RN---KDGDVKS--
1277

EFR83390
664
KNCEA-----SD-GKSLK--YTEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN-N LFE-QN---KEGDIKX--
722

WP_046323366
1216
KNCEA-----SD-GKSLA--YIESHREMFAELLDSISEFASRYTLAD--ANLEKIN-T IFE-QN---KSGDVKV--
1274

AKE81011
1256
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1321

CUO82355
1216
YNAIYKQ-DFDGIDNMLMi-----------QLYLQLIDKLKTLYPIY-mGIVEKFE-K FVS----i----SKEEk-
1272

WP_033162887
1218
YAAMLKK-RYEYIDEEEIf-----------DLYLQLLQKMDTLYPAY-kGIAKRFF-D FKN----i----DVVEK-
1274

AGZ01981
1273
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1338

AKA60242
1240
SHYEKLKgSPEDnEQKOL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

AKS40380
1240
SHYEKLKgSPEDNEQKQL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1305

4UN5_B
1244
SHYEKLKgSPEDnEQKQL--FVEQHKHYLDEIIEQISEFSKRVILAD--ANLDKVL-S AYN-KH---RDKPIREq-
1309

WP_010922251
1306

embedded image

1365

WP_039695303
1309
ISN---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL NATLIHQSITGLYETRIDLSKL--
1369

WP_045635197
1307
LAN---SFI NLLTFTALGAP-AAFKFFG--KDI--DRK--R-YTTVSEIL NATLIHQSITGLYETWIDLSKL--
1367

5AXW_A

--------- ----------------------------------------- ------------------------

WP_009880683
990
-AE---NII HLFTLTNLGAP-AAFKCFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1049

WP_010922251
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_011054416
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_011284745
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATFIHQSITGLYETRIDLSQL--
1365

WP_011285506
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_011527619
1306
-AE---NII HLFTLTNLGAP-TAFKYFD--TTI--DRK--R-YTSTKEVL DATFIHQSITGLYETRIDLSQL--
1365

WP_012560673
1306
-AE---NII HLFTLTNLGAP-AAFKCFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_014407541
1305
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1364

WP_020905136
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_023080005
1305
-AK---NII HLFTLTNLGAP-AAFKYFD--TTI--ERN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1364

WP_023610282
1305
-AK---NII HLFTLTNLGAP-AAFKYFD--TTI--ERN--R-YKSIKEVL DATLIHQSITGLYEIRIDLSQL--
1364

WP_030125963
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_030126706
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_031488318
1306
-AE---NII HLFTLTNFGAP-AAFIYFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_032460140
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_032461047
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_032462016
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_032462936
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_032464890
1306
-AE---NII HLFTLTNLGAP-TAFKYFD--TTI--DRK--R-YTSTKEVL DATFIHQSITGLYETRIDLSQL--
1365

WP_033888930
1131
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1190

WP_038431314
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_038432938
1305
-AK---NII HLFTLTNLGAP-AAFKYFD--TTI--ERN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1364

WP_038434062
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--GRN--R-YKSIKEVL DATLIHQSITGLYETRIDLSQL--
1365

BAQ51233
1217
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1276

KGE60162
481
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
540

KGE60856
244
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
303

WP_002989955
1306
-AE---NII HLFTLTNLGAP-TAFKYFD--TTI--DRK--R-YTSTKEVL DATFIHQSITGLYETRIDLSQL--
1365

WP_003030002
1282
LAK---SFI SLLTFTAFGAP-AAFNFFG--ENI--DRK--R-YTSVTECL NATLIHQSITGLYETRIDLSKL--
1342

WP_003065552
1310
ISN---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL NATLIHQSITGLYETRIDLSKI--
1370

WP_001040076
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040078
1315
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLSKL--
1375

WP_001040080
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040081
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040083
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040085
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040087
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040088
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040089
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040090
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040091
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040092
1307
LAK---NII NLFTFTSLGAP-AAFKFFD--KSV--DRK--R-YTSTKEVL DSTLIHQSITGLYETRIDLGKL--
1367

WP_001040094
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040095
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040096
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040097
130
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040098
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040099
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHKSITGLYETRIDLGKL--
1367

WP_001040100
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040104
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040105
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040106
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040107
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040108
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_001040109
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQFITGLYETRIDLGKL--
1367

WP_001040110
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_015058523
1307
LAK---NII NLFTFTSLGAP-AAFKFFD--KSV--DRK--R-YTSTKEVL DSTLIHQSITGLYETRIDLGKL--
1367

WP_017643650
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_017647151
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_017648376
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_017649527
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_017771611
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_017771984
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

CFQ25032
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

CFV16040
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

KLJ37842
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

KLJ72361
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

KLL20707
1321
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1381

KLL42645
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_047207273
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_047209694
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHKSITGLYETRIDLGKL--
1367

WP_050198062
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_050201642
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_050204027
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_050881965
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KII--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_050886065
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

AHN30376
1307
LAK---NII NLFTFTSLGAP-AAFKFFD--KSV--DRK--R-YTSTKEVL DSTLIHQSITGLYETRIDLGKL--
1367

EAO78426
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

CCW42055
1307
LAN---NII NLFTFTSLGAP-AAFKFFD--KIV--DRK--R-YTSTKEVL NSTLIHQSITGLYETRIDLGKL--
1367

WP_003041502
1314
ICT---SFL GLFELTSLGSA-SDFEFLG--VKI--PRY--RdYTPSSLLK DSTLIHQSITGLYETRIDLSKL--
1383

WP_037593752
1283
LAK---SFI SLLTFTAFGAP-AAFNFFG--ENI--DRK--R-YTSVTECL NATLIHQSITGLYETRIDLSKL--
1343

WP_049516684
1283
LAK---SFI SLLTFTAFGAP-AAFNFFG--ENI--DRK--R-YTSVTECL NATLIHQSITGLYETRIDLSKL--
1343

GAD46167
1282
LAK---SFI SLLTFTAFGAP-AAFNFFG--ENI--DRK--R-YTSVTECL NATLIHQSITGLYETRIDLSKL--
1342

WP_018363470
1314
ISD---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YNSTKECL NATLIHQSITGLYETRIDLSKL--
1374

WP_003043819
1311
-SN---SFV SLLKYTSFGAS-GGFTFLD--LDVkqGRL--R-YQTVTEVL DATLIYQSITGLYETRTDLSQL--
1372

WP_006269658
1282
LAK---SFI SLLTFTAFGAP-AAFNFFG--ENI--DRK--R-YTSVTECL NATLIHQSITGLYETRIDLSKL--
1342

WP_048800889
1302
ISN---SFI HLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL NATLIHQSITGLYETQTDLSKL--
1362

WP_012767106
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_014612333
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_015017095
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_015057649
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_048327215
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_049519324
1309
-CS---SVI NLLTLTASGAP-ADFKFLG--TTI--PRK--R-YGSPQSIL SSTLIHQSITGLYETRIDLSQL--
1368

WP_012515931
1286
-AE---NII NVFTFVALGAP-AAFKFFD--ATI--DRK--R-YTSTKEVL NATLIHQSVTGLYETRIDLSQL--
1345

WP_021320964
1286
-AE---NII NVFTFVALGAP-AAFKFFD--ATI--DRK--R-YTSTKEVL NATLIHQSVTGLYETRIDLSQL--
1345

WP_037581760
1286
-AE---NII NVFTFVALGAP-AAFKFFD--ATI--DRK--R-YTSTKEVL NATLIHQSVTGLYETRIDLSQL--
1345

WP_004232481
1309
ISSlseSFI NLLKFISFGAP-GAFKFLK--LDV--KQSnlR-YKSTTEAL SATLIHQSVTGLYETRIDLSKI--
1374

WP_009854540
1307
ISN---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL TATLIHQSITGLYETRIDLSKL--
1367

WP_012962174
1308
ISI---SFV NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL NATLIHQSITGLYETRIDLSKL--
1368

WP_039695303
1309
ISN---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL NATLIHQSITGLYETRIDLSKL--
1369

WP_014334983
1312
ISA---SFI NLLTLTALGAP-ADFNFLG--EKI--PRK--R-YTSTKECL SATLIHQSVTGLYETRIDLSKL--
1372

WP_003099269
1306
-AI---NML NLFTFTDLGAP-SAFKFFN--GDI--DRK--R-YSSTNEII NSTLIYQSPTGLYETRIDLSKL--
1365

AHY15608

--------- ----------------------------------------- ------------------------

AHY17476

--------- ----------------------------------------- ------------------------

ESR09100
138
-AI---NML NLFTFTDLGAP-SAFKFFNg--DI--DRK--R-YSSTNEII NSTLIYQSPTGLYETRIDLSKL--
197

AGM98575

--------- ----------------------------------------- ------------------------

ALF27331
1282
LAS---SFI NLLTFTAIGAP-AAFKFFD--NNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSRL--
1342

WP_018372492
1290
VAR---SFV -LLNFTMMGAA-TDFKFFG--QII--PRK--R-YPSTTECL KSTLIHQSVTGLYETRIDLSKL--
1350

WP_045618028
1311
LSE---SFI SLLKLISFGAP-GTFKFLG--VEI--SQSnvR-YQSVSSCF NATLIHQSITGLYETRIDLSKL--
1373

WP_045635197
1307
LAN---SFI NLLTFTALGAP-AAFKFFG--KDI--DRK--R-YTTVSEIL NATLIHQSITGLYETWIDLSKL--
1367

WP_002263549
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_002263887
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_002264920
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002269043
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_002269448
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002271977
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002272766
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002273241
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002275430
1282
LSS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002276448
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002277050
1288
LAD---GFI KLLGFTQLGAT-SPFSFLG--IKL--NQK--Q-YTGKKDYL EATLIHQSITGLYETRIDLNKL--
1352

WP_002277364
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002279025
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002279859
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002280230
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002281696
1282
LSS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002282247
1288
LAD---GFI KLLGFTQLGAT-SPFSFLG--IKL--NQK--Q-YTGKKDYL EATLIHQSITGLYETRIDLSKL--
1352

WP_002282906
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002283846
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002287255
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002288990
1282
LAS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002289641
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002290427
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002295753
1282
LAS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002296423
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002304487
1296
LAS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1356

WP_002305844
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002307203
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002310390
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_002352408
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_012997688
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_014677909
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_019312892
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_019313659
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_019314093
1282
LAS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_019315370
1282
LSS---SFI NLLTFTAIGAP-AAFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_019803776
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_019805234
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_024783594
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLNKL--
1342

WP_024784288
1288
LAD---GFI KLLGFTQLGAT-SPFSFLG--IKL--NQK--Q-YTGKKDYL EATLIHQSITGLYETRIDLSKL--
1352

WP_024784666
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_024784894
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_024786433
1288
LAD---GFI KLLGFTQLGAT-SPFSFLG--IKL--NQK--Q-YTGKKDYL EATLIHQSITGLYETRIDLSKL--
1352

WP_049473442
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1342

WP_049474547
1282
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL KATLIHQSITGLYETRIDLSKL--
1342

EMC03581
1275
LAS---SFI NLLTFTAIGAP-ATFKFFD--KNI--DRK--R-YTSTTEIL NATLIHQSITGLYETRIDLSKL--
1335

WP_000428612
1310
LAN---SFI NLLTFTALGAP-AAFKFFG--KDV--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1370

WP_000428613
1308
LAN---SFI NLLTFTALGAP-AAFKFFG--KDI--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1368

WP_049523028
1303
IAN---SFI NLLTFTAFGAP-AVFKFFG--KDI--ERK--R-YSTVTEIL KATLIHQSLTGLYETRIDLSKL--
1363

WP_003107102
1275
-AT---NML NLFTFTGLGAP-ATLKFFN--VDI--DRK--R-YTSSTEIL NSTLIRQSITGLYETRIDLSKI--
1334

WP_054279288
1304
-SI---SFL NLFKFTSFGAP-EKFTFLN--SEIkqDDV--R-YRSTKECL NSTLIHQSVTGLYETRIDLSQF--
1365

WP_049531101
1311
LSE---SFI SLLKLTSFGAP-GAFRFLG--VEI--SQSnvR-YQSVSSCF NATLIHQSITGLYETRIDLSKL--
1373

WP_049538452
1311
LSE---SFI SLLKLTSFGAP-GAFKFLG--VEI--SQSsvR-YKPNSQFL DATLIHQSITGLYETRIDLSKL--
1373

WP_049549711
1313
LSE---SFI SLLKLTSFGAP-GAFKFLG--AEI--SQSsvR-YKPNSQFL DTTLIHQSITGLYETRIDLSKL--
1375

WP_007896501
1312
-AL---NML NLFIFTSLGAP-STFVFFD--ETI--DRK--R-YTTSSDVL NGILIQQSITGLYETRIDLSRF--
1371

EFR44625
1264
-AL---NML NLFIFTSLGAP-STFVFFD--ETI--DRK--R-YTTSSDVL NGILIQQSITGLYETRIDLSRF--
1323

WP_002897477
1307
LAN---SFI NLLTFTALGAP-AAFKFFG--KDV--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1367

WP_002906454
1312
LSE---SFI SLLKLTSFGAP-GAFKFLG--VEI--SQSsvR-YKPNSQFL DTTLIHQSITGLYETRIDLSKL--
1374

WP_009729476
1308
LAN---SFI NLLTFTALGAP-AAFKFFG--KDV--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1368

CQR24647
1296
LAQ---SFI SLLKFTAFGAP-GGFKFLD--ADI--KQSn1R-YQTVTEVL SSTLIHQSVTGLYETRIDLSKL--
1358

WP_000066813
1312
LAN---SFI NLLTFTALGAP-AAFKFLG--KDV--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1372

WP_009754323
1308
LAN---SFI NLLTFTALGAP-AAFKFFG--KDV--DRK--R-YTTVSEIL NATLIHQSITGLYETRIDLSKL--
1368

WP_044674937
1301
LTS---SFV NLLTFTAIGAP-AAFKFLG--SVI--DRK--R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL--
1361

WP_044676715
1303
LTS---SFV NLLTFTAIGAP-AAFKFLG--SVI--DRK--R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL--
1363

WP_044680361
1303
LTS---SFV NLLTFTAIGAP-AAFKFLG--SVI--DRK--R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL--
1363

WP_044681799
1301
LTS---SFV NLLTFTAIGAP-AAFKFLG--SVI--DRK--R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL--
1361

WP_049533112
1314
ICT---SFL GLFELTSLGSA-SDFEFLG--VKI--PRY--RdYTPSSLLK DSTLIHQSITGLYETRIDLSKL--
1383

WP_029090905
1241
-VK----VI ELLKITQANATnGDLKLLK----M-sNREg-R-LGSVSVAL DFKI-INQSVTGLYQSIEDYNN--
1300

WP_006506696
1269
-AN----II QMLIVMHRGPQnGNIVYDDf--KI-sDRIg-R-LKTKNHNL NIVFISQSPTGIYTKKYKL-----
1329

AIT42264
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_034440723
1277
LVE---SFI NLLAITKCGPA-ADITFLG--EKI--SRK--R-YRSINCLW GSEVIFQSPTGLYETRLRLE----
1335

AKQ21048
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

WP_004636532
1272
TVE---SFV NLMTFTAMGAP-ATFKFYG--ESI--TRS--R-YTSITEFR GSTLIFQSITGLYETRYKL-----
1329

WP_002364836
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_016631044
1229
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSPTGLYETRRKV-----
1286

EMS75795
1014
LSQ---SFI NLMQLNAMGAP-ADFKFFD--VII--PRK--R-YPSLTEIW ESTIIYQSITGLRETRTRMATLwd
1076

WP_002373311
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_002378009
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_002407324
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_002413717
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_010775580
1280
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1337

WP_010818269
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_010824395
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_016622645
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_033624816
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_033625576
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_033789179
1278
IAA---SFI QLMQFNAMGAP-STFKFFQ--KDI--ERA--R-YTSIKEIF DATIIYQSTTGLYETRRKV-----
1335

WP_002310644
1280
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1339

WP_002312694
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_002314015
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_002320716
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_002330729
1280
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1339

WP_002335161
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_002345439
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_034867970
1271
IAQ---SFL QLLQFNAIGAP-ADFKFFG--VTI--PRK--R-YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa
1333

WP_047937432
1281
LAS---SFV NLMQFNAMGAP-ADFKFFD--VTI--PRK--R-YTSLTEIW QSTIIHQSITGLYETRIRMGK---
1340

WP_010720994
1271
IAQ---SFL QLLOFNAIGAP-ADFKFFG--VTI--PRK--R-YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa
1333

WP_010737004
1271
IAQ---SFL QLLQFNAIGAP-ADFKFFG--VTI--PRK--R-YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa
1333

WP_034700478
1271
IAQ---SFL QLLQFNAIGAP-ADFKFFG--VTI--PRK--R-YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa
1333

WP_007209003
1270
IAK---SFI NLLTFTAMGAP-ADFEFFG--EKI--PRK--R-YVSISEII DAVFIHQSITGLYETRVRLTEV--
1330

WP_023519017
1265
MID---AIL SLLKFTLFGAS-VEFKFFD--IKI---LK--R-YKSLTDIW EATIIYQSVTGLYERRVEVRKLwd
1326

WP_010770040
1275
IAE---SFV NLMKFSAYGAP-MDFKFFG--KTI--PRS--R-YTSVGELL SATIINQSITGLYETRRKL-----
1332

WP_048604708
1271
IAQ---SFV DLMQLNAFGAP-ADFKFFG--ETI--PRK--R-YTSVNELL EATIINQSITGLYETRRRL-----
1328

WP_010750235
1274
MAH---SFV NLMQFNALGAP-ADFKFFD--TTI--TRK--R-YTSLTEIW QSTIIYQSVTGLYETRRRMADLwd
1336

AII16583
1345
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1404

WP_029073316
1283
-CE----VI QMLVVMHAGPQnGNITFDDf--KL-sNRLg-R-LNCKTISL TTVFIADSPTGMYSKKYKL-----
1343

WP_031589969
1284
-CN----II QILATLHCNSSIGKIMYSDf--KI-sTTIg-R-LNGRTISL DISFIAESPTGMYSKKYKL-----
1344

KDA45870
1254
LGK---NFV ELLRYTADGAA-SDFKFFG--ENI--PRK--R-YNSAGSLL NGTLIYQSKTGLYETRIDLGKL--
1314

WP_039099354
1307
ILDr----V -LIGLHANAAV-SDLGVLKisTPL--GKM--Q---QPSGIS DTQIIYQSPTGLFERRVALRDL--
1368

AKP02966
1297
INS1-eELI TLLHANSTSAH-LIFNNIE-KKAF--GRK-------THGLT DTDFIYQSVTGLYETRIHIE----
1356

WP_010991369
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--TTI--ERK--R-YNNLKELL NSTIIYQSITGLYESRKRL-----
1332

WP_033838504
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--TTI--ERK--R-YNNLKELL NSTIIYQSITGLYESRKRL-----
1332

EHN60060
1278
IAQ---SFV DLMAFNAMGAP-ASFKFFE--TTI--ERK--R-YNNLKELL NSTIIYQSITGLYESRKRL-----
1335

EFR89594
1044
IAQ---SFV DLMAFNAMGAP-ASFKFFE--TTI--ERK--R-YNNLKELL NSTIIYQSITGLYESRKRL-----
1101

WP_038409211
1275
IAK---SFD KLKVFNAFGAP-RDFEFFE--TTI--KRK--R-YYNIKELL NATIIYQSITGLYEARKRL-----
1332

EFR95520
894
IAK---SFD KLKVFNAFGAP-RDFEFFE--TTI--KRK--R-YYNIKELL NATIIYQSITGLYEARKRL-----
951

WP_003723650
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
1332

WP_003727705
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
1332

WP_003730785
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
1332

WP_003733029
1275
IAE---SFV SLKKFNAFGVH-QDFSFFG--TKI--ERK--R-DRKLNELL NSTIIYQSITGLYESRKRL-----
1332

WP_003739838
1275
IAQ---SFV NLMAFNAMGAP-ASFKFFE--ATI--ERK--R-YTNLKELL SATIIYQSITGLYEARKRI-----
1332

WP_014601172
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
1332

WP_023548323
1275
IAE---SFV SLKKFNAFGVH-KDFNFFG--TTI--KRK--R-DRKLKELL NSTIIYQSITGLYESRKRL-----
1332

WP_031665337
1275
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRI-----
1332

WP_031669209
1275
IAE---SFV SLKKFNAFGVH-QDFSFFG--TKI--ERK--R-DRKLNELL NSTIIYQSITGLYESRKRL-----
1332

WP_033920898
1275
IAE---SFV SLKKFNAFGVH-KDFNFFG--TTI--KRK--R-DRKLKELL NSTIIYQSITGLYESRKRL-----
1332

AKI42028
1278
IAQ---SFV DLMAFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
1335

AKI50529
1278
IAE---SFV SLKKFNAFGVH-KDFNFFG--TTI--KRK--R-DRKLKELL NSTIIYQSITGLYESRKRI-----
1335

EFR83390
723
IAQ---SFV DLMVFNAMGAP-ASFKFFE--ATI--DRK--R-YTNLKELL SSTIIYQSITGLYESRKRL-----
780

WP_046323366
1275
IAQ---SFV NLLEFNAMGAP-ASFKYFE--TNI--ERK--R-YNNLKELL NATIIYQSITGLYEARKRL-----
1332

AKE81011
1322
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1381

CUO82355
1273
-AN----VI QMLIIMHKGPQnGNIIYDDf--NV-gKRIg-R-LNGRTFYL NIEFISQSPTGIYTKKYKL-----
1333

WP_033162887
1275
-CD----VI QILIIMHAGPMnGNIMYDDf--KF-tNRIg-R-FTHKNIDL KTTFISTSVTGLFSKKYKL-----
1335

AGZ01981
1339
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1398

AKA60242
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

AKS40380
1306
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1365

4UN5_B
1310
-AE---NII HLFTLTNLGAP-AAFKYFD--TTI--DRK--R-YTSTKEVL DATLIHQSITGLYETRIDLSQL--
1369

WP_010922251
1366
GGD
1368

WP_039695303
1370
GEE
1372

WP_045635197
1368
GED
1370

5AXW_A

---

WP_009880683
1050
GGD
1052

WP_010922251
1366
GGD
1368

WP_011054416
1366
GGD
1368

WP_011284745
1366
GGD
1368

WP_011285506
1366
GGD
1368

WP_011527619
1366
GGD
1368

WP_012560673
1366
GGD
1368

WP_014407541
1365
GGD
1367

WP_020905136
1366
GGD
1368

WP_023080005
1365
GGD
1367

WP_023610282
1365
GGD
1367

WP_030125963
1366
GGD
1368

WP_030126706
1366
GGD
1368

WP_031488318
1366
GGD
1368

WP_032460140
1366
GGD
1368

WP_032461047
1366
GGD
1368

WP_032462016
1366
GGD
1368

WP_032462936
1366
GGD
1368

WP_032464890
1366
GGD
1368

WP_033888930
1191
GGD
1193

WP_038431314
1366
GGD
1368

WP_038432938
1365
GGD
1367

WP_038434062
1366
GGD
1368

BAQ51233
1277
GGD
1279

KGE60162
541
GGD
543

KGE60856
304
GGD
306

WP_002989955
1366
GGD
1368

WP_003030002
1343
GED
1345

WP_003065552
1371
GEE
1373

WP_001040076
1368
GED
1370

WP_001040078
1376
GED
1378

WP_001040080
1368
GED
1370

WP_001040081
1368
GED
1370

WP_001040083
1368
GED
1370

WP_001040085
1368
GED
1370

WP_001040087
1368
GED
1370

WP_001040088
1368
GGD
1370

WP_001040089
1368
GED
1370

WP_001040090
1368
GED
1370

WP_001040091
1368
GED
1370

WP_001040092
1368
GED
1370

WP_001040094
1368
GED
1370

WP_001040095
1368
GEG
1370

WP_001040096
1368
GEG
1370

WP_001040097
1368
GED
1370

WP_001040098
1368
GED
1370

WP_001040099
1368
GED
1370

WP_001040100
1368
GED
1370

WP_001040104
1368
GED
1370

WP_001040105
1368
GED
1370

WP_001040106
1368
GED
1370

WP_001040107
1368
GED
1370

WP_001040108
1368
GED
1370

WP_001040109
1368
GED
1370

WP_001040110
1368
GED
1370

WP_015058523
1368
GED
1370

WP_017643650
1368
GED
1370

WP_017647151
1368
GED
1370

WP_017648376
1368
GED
1370

WP_017649527
1368
GED
1370

WP_017771611
1368
GED
1370

WP_017771984
1368
GED
1370

CFQ25032
1368
GED
1370

CFV16040
1368
GED
1370

KLJ37842
1368
GED
1370

KLJ72361
1368
GGD
1370

KLL20707
1382
GED
1384

KLL42645
1368
GED
1370

WP_047207273
1368
GED
1370

WP_047209694
1368
GED
1370

WP_050198062
1368
GED
1370

WP_050201642
1368
GED
1370

WP_050204027
1368
GED
1370

WP_050881965
1368
GED
1370

WP_050886065
1368
GED
1370

AHN30376
1368
GED
1370

EAO78426
1368
GED
1370

CCW42055
1368
GED
1370

WP_003041502
1384
GED
1386

WP_037593752
1344
GED
1346

WP_049516684
1344
GED
1346

GAD46167
1343
GED
1345

WP_018363470
1375
GEE
1377

WP_003043819
1373
GGD
1375

WP_006269658
1343
GED
1345

WP_048800889
1363
GED
1365

WP_012767106
1369
GGD
1371

WP_014612333
1369
GGD
1371

WP_015017095
1369
GGD
1371

WP_015057649
1369
GGD
1371

WP_048327215
1369
GGD
1371

WP_049519324
1369
GGD
1371

WP_012515931
1346
GEN
1348

WP_021320964
1346
GEN
1348

WP_037581760
1346
GEN
1348

WP_004232481
1375
GEE
1377

WP_009854540
1368
GEE
1370

WP_012962174
1369
GEE
1371

WP_039695303
1370
GEE
1372

WP_014334983
1373
GEE
1375

WP_003099269
1366
GGK
1368

AHY15608

---

AHY17476

---

ESR09100
198
GGK
200

AGM98575

---

ALF27331
1343
GGD
1345

WP_018372492
1351
GEN
1353

WP_045618028
1374
GED
1376

WP_045635197
1368
GED
1370

WP_002263549
1343
GGD
1345

WP_002263887
1343
GGD
1345

WP_002264920
1343
GGD
1345

WP_002269043
1343
GGD
1345

WP_002269448
1343
GGD
1345

WP_002271977
1343
GGD
1345

WP_002272766
1343
GGD
1345

WP_002273241
1343
GGD
1345

WP_002275430
1343
GGD
1345

WP_002276448
1343
GGD
1345

WP_002277050
1353
GGD
1355

WP_002277364
1343
GGD
1345

WP_002279025
1343
GGD
1345

WP_002279859
1343
GGD
1345

WP_002280230
1343
GGD
1345

WP_002281696
1343
GGD
1345

WP_002282247
1353
GGD
1355

WP_002282906
1343
GGD
1345

WP_002283846
1343
GGD
1345

WP_002287255
1343
GGD
1345

WP_002288990
1343
GGD
1345

WP_002289641
1343
GGD
1345

WP_002290427
1343
GGD
1345

WP_002295753
1343
GGD
1345

WP_002296423
1343
GGD
1345

WP_002304487
1357
GGD
1359

WP_002305844
1343
GGD
1345

WP_002307203
1343
GGD
1345

WP_002310390
1343
GGD
1345

WP_002352408
1343
GGD
1345

WP_012997688
1343
GGD
1345

WP_014677909
1343
GGD
1345

WP_019312892
1343
GGD
1345

WP_019313659
1343
GGD
1345

WP_019314093
1343
GGD
1345

WP_019315370
1343
GGD
1345

WP_019803776
1343
GGD
1345

WP_019805234
1343
GGD
1345

WP_024783594
1343
GGD
1345

WP_024784288
1353
GGD
1355

WP_024784666
1343
GGD
1345

WP_024784894
1343
GGD
1345

WP_024786433
1353
GGD
1355

WP_049473442
1343
GGD
1345

WP_049474547
1343
GGD
1345

EMC03581
1336
GGD
1338

WP_000428612
1371
GED
1373

WP_000428613
1369
GED
1371

WP_049523028
1364
GEE
1366

WP_003107102
1335
GGD
1337

WP_054279288
1366
GGD
1368

WP_049531101
1374
GED
1376

WP_049538452
1374
GED
1376

WP_049549711
1376
GED
1378

WP_007896501
1372
GGD
1374

EFR44625
1324
GGD
1326

WP_002897477
1368
GEE
1370

WP_002906454
1375
GED
1377

WP_009729476
1369
GED
1371

CQR24647
1359
GGE
1361

WP_000066813
1373
GED
1375

WP_009754323
1369
GED
1371

WP_044674937
1362
GGD
1364

WP_044676715
1364
GGD
1366

WP_044680361
1364
GGD
1366

WP_044681799
1362
GGD
1364

WP_049533112
1384
GED
1386

WP_029090905

---

WP_006506696

---

AIT42264
1366
GGD
1389

WP_034440723

---

AKQ21048
1366
GGD
1384

WP_004636532
1330
-ED
1332

WP_002364836
1336
-VD
1337

WP_016631044
1287
-VD
1288

EMS75795
1077
GEQ
1079

WP_002373311
1336
-VD
1337

WP_002378009
1336
-VD
1337

WP_002407324
1336
-VD
1337

WP_002413717
1336
-VD
1337

WP_010775580
1338
-VD
1339

WP_010818269
1336
-VD
1337

WP_010824395
1336
-VD
1337

WP_016622645
1336
-VD
1337

WP_033624816
1336
-VD
1337

WP_033625576
1336
-VD
1337

WP_033789179
1336
-VD
1337

WP_002310644

---

WP_002312694

---

WP_002314015

---

WP_002320716

---

WP_002330729

---

WP_002335161

---

WP_002345439

---

WP_034867970
1334
GEQ
1336

WP_047937432

---

WP_010720994
1334
GEQ
1336

WP_010737004
1334
GEQ
1336

WP_034700478
1334
GEQ
1336

WP_007209003

---

WP_023519017
1327
GER
1330

WP_010770040
1333
-VD
1334

WP_048604708
1329
-GD
1330

WP_010750235
1337
GVQ
1339

AII16583
1405
GGD
1424

WP_029073316

---

WP_031589969

---

KDA45870

---

WP_039099354

---

AKP02966

---

WP_010991369
1333
-DD
1334

WP_033838504
1333
-DD
1334

EHN60060
1336
-DD
1337

EFR89594
1102
-DD
1103

WP_038409211
1333
-ED
1334

EFR95520
952
-ED
953

WP_003723650
1333
-DD
1334

WP_003727705
1333
-DD
1334

WP_003730785
1333
-DD
1334

WP_003733029
1333
-DN
1334

WP_003739838
1333
-DG
1334

WP_014601172
1333
-DD
1334

WP_023548323
1333
-DS
1334

WP_031665337
1333
-DD
1334

WP_031669209
1333
-DN
1334

WP_033920898
1333
-DS
1334

AKI42028
1336
-DD
1337

AKI50529
1336
-DS
1337

EFR83390
781
-DD
782

WP_046323366
1333
-DD
1334

AKE81011
1382
GGD
1400

CUO82355

---

WP_033162887

---

AGZ01981
1399
GGD
1417

AKA60242
1366
GGD
1368

AKS40380
1366
GGD
1376

4UN5_B
1370
GGD
1372

Additional suitable Cas9 sequences in which amino acid residues homologous to residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and/or 1329 of SEQ ID NO: 9 can be identified are known to those of skill in the art. See, e.g., Supplementary Table S2 and Supplementary Figure S2 of Fonfara et al., Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems, Nucl. Acids Res. 2013, doi: 10.1093/nar/gkt1074, which are incorporated herein by reference in their entirety. Cas9 variants of the sequences provided herein or known in the art comprising one or more mutations, e.g., at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations as provided herein, e.g., of one or more amino acid residue that is homologous to amino acid residue 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and/or 1329 in SEQ ID NO: 9 are provided by this disclosure, for example, Cas9 variants comprising a A262T, K294R, S409I, E480K, E543D, M694I, and/or E1219V mutation.

Example 4: Evolution of Cas9 with Broadened PAM Specificities

By evolving S. pyogenes Cas9 on a NNN PAM library using PACE, Cas9s with broadened PAM specificities have been evolved with higher activities for many non-canonical PAMs. Such a Cas9 still retains its native DNA binding and cutting activity and can be utilized with all of the current tools available. It has been hypothesized that by modulating Cas9's interactions with the DNA, the PAM specificity of Cas9 can be modified and expanded. Other Cas9s such as Staphylococcus aureus could also be engineered to change and expand their PAM specificity by such a method. Methods to modulate DNA binding such as targeted mutagenesis of the Cas9 protein, fusions to DNA-binding proteins, and the use of multiple Cas9 proteins tethered to each other could also expand the PAMs that can be targeted.

Cas9 Evolution. After evolution using overnight propagation of the phage with the mutagenesis plasmid (MP), the resultant phages containing mutations, discussed above, in PACE were used. Twenty-four individual phages were sequenced from the PACE run. Mutations found in the Cas9 gene are documented in Table 3 below. The Cas9 gene containing these mutations was cloned out of the phage and into plasmids to test both DNA binding and cutting activity.

TABLE 3

Cas9 mutations

pJH306 (WT

dCas9-VPR)

pJH407

(WT Cas9)

pJH562

E480K
E543D

E1219V

(dCas9-VPR)

pJH599
A262T

S409I
E480K
E543D
M694I
E1219V

(dCas9-VPR)

pJH600

K294R

E480K
E543D

E1219V

Q1256K
L1362P

(dCas9-VPR)

pJH601
A262T

S409I
E480K
E543D
M694I
E1219V

(dCas9-VPR)

pJH602

K294R

E480K
E543D

E1219V

Q1256K

(dCas9-VPR)

pJH603
A262T

S409I
E480K
E543D
M694I
E1219V

(dCas9-VPR)

pJH604

S267G
K294R

E480K
E543D

E1219V
N1224K
Q1256K

(dCas9-VPR)

pJH605
A262T

F405I
S409I
E480K
E543D
M694I
E1219V

(dCas9-VPR)

pJH760 (pJH599
A262T

S409I
E480K
E543D
M694I
E1219V

Minus VPR,

Nuclease

Positive)

GFP Activation in Human Cell Culture. Testing was performed on a reporter with a GFP reporter activated by dCas9-VPR. Testing was performed on 5′-NGG-3′ PAM first (FIGS. 4A and 4B) and then with a library of GFP reporters all containing the same Cas9 target site, but with NNN at the PAM position (FIGS. 5A and 5B). In this testing, dCas9-VPR was found to activate the GFP signal. Wild-type Cas9 with no mutations (pJH306), Cas9 evolved from overnight propagation (pJH562), and Cas9 evolved from PACE (pJH599-pJH605) were all tested. Mutations for each Cas9 are documented in Table 3 above.

dCas9-VPR on all 64 PAM Sequences. pJH306 (WT dCas9-VPR) and pJH599 (WT dCas9-VPR with mutations A262T, S409I, E480K, E543D, M694I, and E1219V) were tested on all 64 PAM sequences (FIG. 6). dCas9-VPR was used to activate GFP as before and a different reporter plasmid was used for each well to ascertain the activation efficiency for all 64 different PAM sequences. The mean GFP fluorescence was measured for all transfected cells, as gated by iRFP signal. pJH599 showed either improved or similar levels of activation as compared to pJH306 for all PAM sequences.

In Vitro Cutting Assay. The ability of expressed and purified WT Cas9 (WT) and Cas 9 with an E1219V mutation (1) to cut DNA with different PAMs was tested (FIG. 7). Cas9 was incubated with dsDNA containing the target site. Cutting was measured by running the DNA on a gel to compare the amount of uncut product to the amount of cut products, which run faster due to their smaller size. The E1219V mutation was found to increase Cas9 cutting activity on non-canonical PAMs while maintaining activity on 5′-NGG-3′ PAMs.

Evolving Different Systems. In addition to S. pyogenes Cas9 evolution, other Cas9 systems such as S. aureus, S. thermophilus, N. meningitidis, and T. denticola, etc. can be evolved to modify and expand their PAM specificities. The data indicates that, by using a similar system to the S. pyogenes Cas9 evolution, a phage containing the S. aureus Cas9 can also be evolved to expand its PAM specificity.

Modulating PAM Specificity. By mutating neutral and negatively charged amino acids to positively charged amino acids, Cas9 could be modified to expand the PAMs that can be targeted. Generally, incorporating mutations into Cas9 proteins that generate a net increase in positive charge may increase the affinity of Cas9 to bind DNA. In combination with the Cas9 mutations provided herein, additional residues that could be mutated for increased PAM targeting in S. pyogenes Cas9 further include ones that have been identified to change the PAM specificity (D1135, G1218, R1333, R1335, T1337) 38 and residues that can increase Cas9 activity (S845 and L847) 37. Residues that increase Cas9 specificity such as the mutations of arginine, histidine, and lysine to alanine previously identified³⁷and the mutations of asparagine, arginine, and glutamine to alanine as previously identified³⁹could lead to lower tolerability for non-canonical PAMs as these mutations presumably decrease the interactions between the Cas9 and DNA.

Fusions to Modulate PAM Specificity. Programmable DNA-binding proteins such as zinc-finger domains, TALEs, and other Cas9 proteins could be fused to Cas9 to improve the ability to target nucleotide sequences having canonical or non-canonical PAMs, for example to increase activity, specificity or efficiency. A nuclease-null dCas9 could be fused to a nuclease active Cas9 to increase the ability of the nuclease active Cas9 to target different PAM sequences. One example of a nuclease-null dCas9 fused to a nuclease active Cas9 is shown in FIG. 8. Such fusions can be useful for improving the ability to target nucleotide sequences having canonical or non-canonical PAMs. The Cas9s could either be from the same species or from different species. Furthermore, both Cas9s could be nuclease-null dCas9, and could be further fused to effector proteins such as VP64, VP64-p65-Rta, FokI, GFP and other fluorescent proteins, deaminases, or any of the effector proteins provided herein.

Using Cas9 to Localize Other Nucleases and Other DNA-Binding Proteins. Cas9 can also be used to overcome the native binding specificity of other proteins by localizing them to their DNA targets. DNA nucleases, recombinases, deaminases, and other effectors often have a native DNA specificity. Cas9 can be fused to these proteins to overcome and expand their native DNA specificities. gRNAs will target the Cas9 adjacent to the DNA effector's target site and will help to localize them to their target site.

dCas9-VPR on NNNNN PAM Library. To test that the evolved Cas9s had not picked up specificity in the 4th and 5th PAM positions, dCas9-VPR on a NNNNN PAM library was tested. As seen with the NNN library, most of the constructs (e.g., pJH562, pJ559, pJH600, pJH601, pJH602, pJH603, and pJH605) showed improved activity. pJH599 consistently showed improvement in both the percentage of cells that showed GFP activation (FIG. 9A) and the mean fluorescence of those cells that showed GFP activation (FIG. 9B).

Cas9 GFP Cutting. The WT Cas9, pJH407, was compared with a nuclease-positive evolved Cas9, pJH760 (FIG. 10). pJH760 contained the same mutations as pJH599 but without the D10A and H480A nuclease-inactivating mutations, and without the VPR fusion. A genomically integrated GFP gene was cut by Cas9 and the activity was measured by the loss of GFP signal in cells. On a site with 5′-NGG-3′ PAM, pJH407 and pJH760 showed comparable activity. On a site with GAT PAM, pJH760 showed a significant increase in activity as compared to pJH407.

Example 5 Cas9:DNA Editing Enzyme Fusion Proteins

This disclosure further provides Cas9 fused with a DNA editing enzyme for the targeted editing of DNA sequences. FIG. 11 illustrates double stranded DNA substrate binding by DNA editing enzyme-dCas9:sgRNA complexes. The DNA editing enzyme shown is a deaminase. The structures according to FIG. 11 are identified in these sequences (36 bp: underlined, sgRNA target sequence: bold; PAM: boxed; 21 bp: italicized).

Example 6 PAM Depletion Assay

In E. coli, a library of PAM sequences are encoded in a plasmid that also contains an antibiotic gene. If the Cas9 can cut the PAM sequences on the plasmid, the plasmid is not replicated and is lost; only plasmids that are uncut remain the population. The plasmids that were cut by the Cas9 can be determined by sequencing the initial plasmid population and the final plasmid population through high throughput sequencing. The proportion of the library consisting of each PAM sequence was obtained by dividing the number of reads containing the PAM sequence by the total number of reads. The depletion score was then calculated by dividing the proportion of the library containing the PAM section before the selection by the proportion of the library containing the PAM sequence after selection. Higher depletion scores signify higher cutting activity by the Cas9 of that particular PAM sequence. The results of the PAM depletion assay are shown in FIG. 12.

A number of PAM sequences that were not cut with the wild-type Cas9 were cut with the evolved Cas9 (xCas9 v1.0, pJH760). Notably, all PAM sequences of the form NGN and NNG, as well as GAA and GAT showed a depletion greater than 10-fold with the xCas9. A single G in either the second or third PAM position could be sufficient for cutting with the newly evolved Cas9, opening up the sequence space significantly for the target sites that can be targeted using Cas9. The PAM depletion scores are given in Table 4.

TABLE 4

PAM Depletion Scores

PAM Sequence
WT Cas9
xCas9 v1.0

TCG
0.96
32.75

CAG
12.63
32.01

GCG
1.38
31.14

ACG
1.12
30.15

TGG
18.99
30.13

TGT
1.01
28.37

GGC
11.78
28.17

AGA
1.25
27.80

GAG
19.47
27.71

GGT
12.22
27.59

CGA
1.27
27.53

CGT
0.97
27.30

TGA
1.72
27.02

GGA
16.03
26.90

AGG
17.80
26.19

TAG
9.54
25.98

CGC
1.76
25.88

AGT
0.97
24.88

CGG
19.03
24.77

AAG
15.40
24.16

GTG
3.76
23.71

ATG
1.26
23.48

GGG
17.59
23.01

TGC
1.71
23.00

TTG
0.98
22.15

GAA
1.04
20.96

AGC
1.43
16.85

GAT
1.02
16.09

CTG
1.29
13.88

CCG
1.02
11.86

CAT
0.99
5.75

CAA
1.00
5.28

GAC
0.98
3.96

TAA
0.97
1.90

AAA
1.02
1.81

TAT
0.95
1.56

CAC
1.01
1.48

GTA
0.94
1.42

AAT
0.98
1.39

GCA
0.98
1.22

ACA
0.95
1.13

AAC
1.08
1.09

TAC
0.92
0.95

ATA
1.04
0.94

GTC
0.99
0.92

GCT
0.99
0.87

TCA
0.94
0.84

CTA
0.95
0.83

GCC
0.99
0.82

GTT
0.97
0.81

TCC
0.98
0.80

ACC
0.96
0.80

CTC
0.92
0.80

CCA
0.97
0.79

CCC
0.95
0.79

CTT
0.96
0.79

ATC
0.96
0.78

CCT
0.94
0.78

ATT
0.93
0.77

ACT
0.89
0.77

TTT
0.94
0.77

TCT
0.95
0.77

TTC
0.96
0.76

TTA
0.94
0.76

Example 7: GFP Cutting Mammalian Cells

Wild-type or evolved Cas9 and gRNAs were transfected into mammalian cells containing a genomically integrated GFP gene. Different gRNAs targeted different sites with different PAM sequences, such that cutting of the GFP by Cas9 would lead to a loss of the GFP signal. The GFP signal was quantified after five days with flow cytometry. As shown in FIG. 13, evolved Cas9 cut GFP in mammalian, in line with the results in the GFP activation assay and in the PAM depletion assay. High throughput sequencing around the cut site verified the results seen with the flow cytometer; the indels were proportional to the cutting percentage seen with the flow cytometer.

Example 8: Further Evaluation of the HHH Library

As SpCas9 has a preference for the G residues at the second and third base, evaluation was continued using the end point from the last evolution on a HHH (H=A, C, or T) PAM library. After evolution, 13 colonies were sequenced and a number of new mutations were identified. Three mutations, the E1219V, E480K, and E543D mutations were found in all the clones. A number of the clones either had the S267G/K294R/Q1256K mutations or the A262T/S409I mutations but those mutations were never seen together, suggesting that the clones had taken two divergent paths along the evolutionary landscape. The new mutations are given in Table 5.

TABLE 5

New Mutations

HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH
HHH

#1
#2
#3
#4
#5
#6
#7
#8
#9
#10
#11
#12
#13

(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9
(xCas9

2.0)
2.1)
2.2)
2.3)
2.4)
2.5)
2.6)
2.7)
2.8)
2.9)
2.10)
2.11)
2.12)

D23N

E108G

R115H

K141Q

D180N

P230S

P230S

D257N

A262T

A262T

A262T

S267G
S267G

S267G

S267G

S267G

S267G
S267G

D284N

K294R
K294R

K294R

K294R

K294R
K294R

K294R
K294R

R324L

Q394H

S409I

S409I

S409I

S409I

LA55F

T466A

T474I

E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K

E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D

K554R

R654L

M694I

M694I

M694I

A711E

L727P

M763I

I1063V

V1100I

E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V

K1244N

Q1256K
Q1256K

Q1256K

Q1256K

Q1256K
Q1256K

Q1256K
Q1256K

K1289Q

A1323S

Example 9: Further Evolved Cas9 Proteins for Gene Editing

pJH760, described in Example 6, was tested in the PAM depletion assay on a number of new targets. Four new targets were selected: re2 (GGGGCCACTAGGGACAGGAT (SEQ ID NO: 314)), a synthetic target previously used for GFP activation in mammalian cells; VEGF (GGGTGGGGGGAGTTTGCTCC (SEQ ID NO: 315)), a target within the VEGF gene, CLTA (GCAGATGTAGTGTTTCCACA (SEQ ID NO: 316)), a target within the CLTA gene; and CCR5D (TCACTATGCTGCCGCCCAGT (SEQ ID NO: 317)), a target within the CCR5D gene. The results of the PAM depletion assay are given in FIGS. 14 to 17. It was found that, in addition to the canonical NGG sequence, PAM depletion demonstrates cutting for most NGN and some NNG sequences as well.

The HHH PAM library was further evolved using the end point from the last evolution on a HHH (H=A, C, or T) PAM library. After evolution, 13 colonies were sequenced and a number of new mutations were identified. Three mutations, the E1219V, E480K, and E543D mutations were found in all the clones. A number of the clones either had the K294R/Q1256K mutations or the A262T/S409I mutations but those mutations were never seen together, suggesting that the clones had taken two divergent paths along the evolutionary landscape. The new mutations are given in Tables 8 and 9 below.

As expected, variation in activity was seen with different targets. The PAM depletion assay scores are given in Table 10. NGN consistently showed cutting activity with some targets. Variation was seen amongst the xCas9 3.x mutants in terms of which mutant had the best activity. Of note, xCas9 3.3 contained the K294R/Q1256K series of mutations, while the other three mutants (3.6, 3.7, and 3.8) contained the A262T/S409I series of mutations. xCas9 3.6 and 3.7 outperformed 3.8. While 3.3 seemed to have the highest activity for most cases, 3.6 and 3.7 performed better on certain PAM sequences. The results of the PAM depletion assays for three of the new targets described above are given in FIGS. 18 to 20.

A NNNNN PAM depletion library was constructed. It was assayed to examine any fourth or fifth base specificity. Initial results of the PAM depletion assay show that there is no preference at the fourth and fifth base as expected.

In summary, E1219V was found to be one of the earliest mutations that fixed in the evaluation. It is close to the PAM sequence in the crystal structure. E480K and E543D were also seen in all of the clones from the early stages of the evolution, and may be important. K294R/Q1256K and A262T/S409I seem to be two divergent paths, and may be important. Their PAM sequence profiles seem to be slightly different, which implies their importance relative to PAM activity determination.

TABLE 6

Diseases/disorders containging T to C Changes. The table includes human gene

mutations that may be corrected by changing a cytosine (C) to a thymine (T). The gene

name, gene symbol,and Gene ID are indicated.

SEQ

ID

Gene
Gene

NO:
Name
ID
Symbol
Flanks

674
NM_000410.3(HFE): c.314T > C
3077
HFE
[′ATGTTCACTGTTGACTTCTGGACTAYTATGG

(p.Ile105Thr)

AAAATCACAACCACAGCAAG′]

675
NM_144631.5(ZNF513):
130557
ZNF513
[′GCTGGGAGCTGCCATGTGTGGGCGCYGCAT

c.1015T > C (p.Cys339Arg)

GCGAGGAGAGGCTGGAGGGGG′]

676
NM_001199107.1(TBC1D24):
57465
TBC1D24
[′CGTGGCGCTGGCCATCCTCAAGTTCYTCCAC

c.751T > C (p.Phe251Leu)

AAGGTGAGGGCCGGGCAGCC′]

677
NM_001708.2(OPN1SW):
611
OPN1SW
[′CATCTTCTGCTTCATTGTGCCTCTCBCCCTCA

c.640T > C (p.Ser214Pro)

TCTGCTTCTCCTACACTCA′]

678
NM_000235.3(LIPA): c.599T > C
3988
LIPA
[′AAAAGGATTAAAATGTTTTTTGCCCYGGGTC

(p.Leu200Pro)

CTGTGGCTTCCGTCGCCTTC′]

679
NM_000071.2(CBS): c.833T > C
875
CBS
[′CTGAAGCCGCGCCCTCTGCAGATCAYTGGG

(p.Ile278Thr)

GTGGATCCCGAAGGGTCCATC′]

680
NM_000071.2(CBS): c.1616T > C
875
CBS
[′TTCGGGGTGGTCACCGCCATTGACTYGCTGA

(p.Leu539Ser)

ACTTCGTGGCCGCCCAGGAG′]

681
NM_033409.3(SLC52A3):
113278
SLC52A3
[′CGCCCACTTCTCACCCCTGGTCTTCYTCCTCC

c.670T > C (p.Phe224Leu)

TCCTATCCATCATGATGGC′]

682
NM_033409.3(SLC52A3):
113278
SLC52A3
[′CTTTTCAGCGGCTGCCTCAGTTACGYCAAGG

c.1238T > C (p.Val413Ala)

TGATGCTGGGCGTGGTCCTG′]

683
NM_000274.3(OAT): c.163T > C
4942
OAT
[′GGAATATAAGTATGGTGCACACAACYACCA

(p.Tyr55His)

TCCTTTACCTGTAGCCCTGGA′]

684
NM_000274.3(OAT): c.1205T > C
4942
OAT
[′TGTCTACGACTTCGAGATAATGGACYTCTGG

(p.Leu402Pro)

CCAAGCCAACCCATGGCGAC′]

685
NM_000274.3(OAT): c.1180T > C
4942
OAT
[′TTTAGATTGGGATGCTTGGAAGGTGYGTCTA

(p.Cys394Arg)

CGACTTCGAGATAATGGACT′]

686
NM_001385.2(DPYS): c.1078T >
1807
DPYS
[′TGTTGAAGATCGGATGTCCGTAATAYGGGA

C (p.Trp360Arg)

AAAAGGCGTGGTGGGTTTCAC′]

687
NM_000027.3(AGA): c.916T > C
175
AGA
[′TCCAGAATTCTTTGGGGCTGTTATAYGTGCC

(p.Cys306Arg)

AATGTGACTGGAAGTTACGG′]

688
NM_000027.3(AGA): c.214T > C
175
AGA
[′GTGTGAGAGAGAGCAGTGTGACGGCYCTGT

(p.Ser72Pro)

AGGCTTTGGAGGAAGTCCTGA′]

689
NM_000398.6(CYB5R3):
1727
CYB5R3
[′CAAGTTTCCCGCTGGAGGGAAGATGYCTCA

c.382T > C (p.Ser128Pro)

GTACCTGGAGAGCATGCAGAT′]

690
NM_000398.6(CYB5R3):
1727
CYB5R3
[′GAGTTCCGGGGCCCCAGTGGGCTGCYGGTC

c.446T > C (p.Leu149Pro)

TACCAGGGCAAAGGTGATTCG′]

691
NM_000398.6(CYB5R3):
1727
CYB5R3
[′GAAGGACCCTGATGACCACACTGTGYGCCA

c.610T > C (p.Cys204Arg)

CCTGCTCTTTGCCAACCAGGT′]

692
NM_000398.6(CYB5R3):
1727
CYB5R3
[′CCGTCACCCCAGCACATCCTGGGCCYCCCTG

c.218T > C (p.Leu73Pro)

TCGGTGAGTCACGCCCCTGC′]

693
NM_000552.3(VWF): c.4883T > C
7450
VWF
[′CCTGGAGACATCCAGGTGGTGCCCAYTGGA

(p.Ile1628Thr)

GTGGGCCCTAATGCCAACGTG′]

694
NM_000552.3(VWF): c.4837T > C
7450
VWF
[′CTACATGGTCACCGGAAATCCTGCCYCTGAT

(p.Ser1613Pro)

GAGATCAAGAGGCTGCCTGG′]

695
NM_000552.3(VWF): c.3814T > C
7450
VWF
[′GGAACCGCCGTTGCACGATTTCTACBGCAGC

(p.Cys1272Arg)

AGGCTACTGGACCTGGTCTT′]

696
NM_000552.3(VWF): c.8317T > C
7450
VWF
[′CAACGATGTGCAGGACCAGTGCTCCYGCTG

(p.Cys2773Arg)

CTCTCCGACACGGACGGAGCC′]

697
NM_000552.3(VWF): c.3445T > C
7450
VWF
[′TGAGTGTGAGTGGCGCTATAACAGCYGTGC

(p.Cys1149Arg)

ACCTGCCTGTCAAGTCACGTG′]

698
NM_000552.3(VWF): c.3178T > C
7450
VWF
[′GAAGCAGACGATGGTGGATTCCTCCYGTAG

(p.Cys1060Arg)

AATCCTTACCAGTGACGTCTT′]

699
NM_001042492.2(NF1): c.5858T
4763
NF1
[′TGTTTGGAATACATGACTCCATGGCYGTCAA

> C (p.Leu1953Pro)

ATCTAGTTCGTTTTTGCAAG′]

700
NM_000267.3(NF1): c.1523T > C
4763
NF1
[′ATTCATGCAGATCCAAAGCTCTTGCYTTGTG

(p.Leu508Pro)

TAAGTATTTTTTTATGAAAT′]

701
NM_000267.3(NF1): c.6200T > C
4763
NF1
[′ATTTTAGCACGCTACATGCTGATGCYGTCCT

(p.Leu2067Pro)

TCAACAATTCCCTTGATGTG′]

702
NM_000267.3(NF1): c.1070T > C
4763
NF1
[′CTGTTGGGGTTTTTATAGAACCTGCYTTTTA

(p.Leu357Pro)

ATCCAAGTAAGCCATTCTCA′]

703
NM_000267.3(NF1): c.3728T > C
4763
NF1
[′TCTCAGGATGAACTAGCTCGAGTTCYGGTTA

(p.Leu1243Pro)

CTCTGTTTGATTCTCGGCAT′]

704
NM_000308.2(CTSA): c.247T > C
5476
CTSA
[′CTCCGGCTCCAAGCACCTCCACTACYGGTCT

(p.Trp83Arg)

GCCGCCCTGCCTTCTGGGCG′]

705
NM_001127695.1(CTSA):
5476
CTSA
[′ATCTCCTACAGGCTTTGGTCTTCTCYCCAGA

Tc.707 > C (p.Leu236Pro)

CCCACTGCTGCTCTCAAAAC′]

706
NM_000308.2(CTSA): c.1271T >
5476
CTSA
[′GATGTAGACATGGCCTGCAATTTCAYGGGG

C (p.Met424Thr)

GATGAGTGGTTTGTGGATTCC′]

707
NM_000405.4(GM2A): c.412T >
2760
GM2A
[′GCGTACCTATGGGCTTCCTTGCCACYGTCCC

C (p.Cys138Arg)

TTCAAAGAAGTAAGTACTTA′]

708
NM_001165974.1(UROC1):
131669
UROC1
[′CCAGAGTTTGCCCAGGAGCTGCAACYGTAC

c.209T > C (p.Leu70Pro)

GGACACATCTACATGTACCGG′]

709
NM_003730.4(RNASET2):
8635
RNASET2
[′ATATGGAGTGATACCCAAAATCCAGYGCCT

c.550T > C (p.Cys184Arg)

TCCACCAAGCCAGGTTAGACA′]

710
NM_199069.1(NDUFAF3):
25915
NDUFAF3
[′GACTTCGCCGCGCGTTGGTCAGCCAYGGCC

c.2T > C (p.Met1Thr)

ACCGCTCTCGCGCTACGTAGC′]

711
NM_178012.4(TUBB2B):
347733
TUBB2B
[′CATGAACACCTTCAGCGTCATGCCCYCACCC

c.514T> C (p.Ser172Pro)

AAGGTGTCAGACACGGTGGT′]

712
NM_178012.4(TUBB2B):
347733
TUBB2B
[′CCCACCTACGGGGACCTCAACCACCYGGTG

c.683T > C (p.Leu228Pro)

TCGGCCACCATGAGCGGGGTC′]

713
NM_178012.4(TUBB2B):
347733
TUBB2B
[′CATGGTGCCCTTCCCTCGCCTGCACYTCTTC

c.793T > C (p.Phe265Leu)

ATGCCCGGCTTCGCGCCCCT′]

714
NM_000110.3(DPYD): c.85T > C
1806
DPYD
[′TCGAACACAAACTCATGCAACTCTGYGTTCC

(p.Cys29Arg)

ACTTCGGCCAAGAAATTAGA′]

715
NM_133459.3(CCBE1): c.520T >
147372
CCBE1
[′CATCCGGGAAGATGATGGGAAGACAYGTAC

C (p.Cys174Arg)

CAGGGGAGACAAATATCCCAA′]

716
NM_000035.3(ALDOB): c.442T >
229
ALDOB
[′GAAAGATGGTGTTGACTTTGGGAAGYGGCG

C (p.Trp148Arg)

TGCTGTGCTGAGGATTGCCGA′]

717
NM_000320.2(QDPR): c.106T > C
5860
QDPR
[′AACCAAAGCTGTTTTCTCCTTCCAGYGGGTT

(p.Trp36Arg)

GCCAGCGTTGATGTGGTGGA′]

718
NM_173560.3(RFX6):
222546
RFX6
[′GCAGACACAGCTCACGCTGCAGTGGYGAGA

c.380+2T > C

CTCGCCCGCAGGGTACACTGA′]

719
NM_173560.3(RFX6): c.649T > C
222546
RFX6
[′AAAATGTACTAATTTTTTAAGGTTTYCTGGA

(p.Ser217Pro)

AGCAAGCTAAAGAATGAGGT′]

720
NM_000037.3(ANK1):
286
ANK1
[′CTGCGGGGCCTGTGACGTGCGGGCCRGGCC

c.−108T > C

CCCGAGGGCCTTATCGGCCCC′]

721
NM_001145308.4(LRTOMT):
220074
LRTOMT
[′TCACATCCTCACCACCCTGGACCACYGGAGC

c.313T > C (p.Trp105Arg)

AGCCGCTGCGAGTACTTGAG′]

722
NM_001012515.2(FECH):
2235
FECH
[′CCTGTCTGCAGGGAGACTAAATCCTYCTTCA

c.1268T > C (p.Phe423Ser)

CCAGCCAGCAGCTGTGACCC′]

723
NM_000140.3(FECH):
2235
FECH
[′TATTGAGTAGAAAACATTTCTCAGGYTGCTA

c.315 − 48T > C

AGCTGGAATAAAATCCACTT′]

724
NM_024120.4(NDUFAF5):
79133
NDUFAF5
[′GCTGTCAATGACCTGGGACATCTGCYTGGG

c.686T > C (p.Leu229Pro)

AGAGCTGGCTTTAATACTCTG′]

725
NM_000277.1(PAH): c.932T > C
5053
PAH
[′TTACAGGAAATTGGCCTTGCCTCTCYGGGTG

(p.Leu311Pro)

CACCTGATGAATACATTGAA′]

726
NM_000277.1(PAH): c.764T > C
5053
PAH
[′GGCCTGCTTTCCTCTCGGGATTTCTYGGGTG

(p.Leu255Ser)

GCCTGGCCTTCCGAGTCTTC′]

727
NM_000277.1(PAH): c.143T > C
5053
PAH
[′TCACTCAAAGAAGAAGTTGGTGCATYGGCC

(p.Leu48Ser)

AAAGTATTGCGCTTATTTGAG′]

728
NM_000277.1(PAH): c. 1045T > C
5053
PAH
[′AAAGGCATATGGTGCTGGGCTCCTGBCATCC

(p.Ser349Pro)

TTTGGTGAATTACAGGTATG′]

729
NM_000277.1(PAH): c.293T > C
5053
PAH
[′GCTCTGACAAACATCATCAAGATCTYGAGG

(p.Leu98Ser)

CATGACATTGGTGCCACTGTC′]

730
NM_000277.1(PAH): c.734T > C
5053
PAH
[′TGCACTGGTTTCCGCCTCCGACCTGHGGCTG

(p.Val245Ala)

GCCTGCTTTCCTCTCGGGAT′]

731
NM_000277.1(PAH): c.194T > C
5053
PAH
[′GAGAATGATGTAAACCTGACCCACANTGAA

(p.Ile65Thr)

TCTAGACCTTCTCGTTTAAAG′]

732
NM_000130.4(F5): c.1160T > C
2153
F5
[′CATTTGGATAATTTCTCAAACCAAAYTGGAA

(p.Ile387Thr)

AACATTATAAGAAAGTTATG′]

733
NM_000512.4(GALNS): c.413T >
2588
GALNS
[′AAGGCCGGCTACGTCAGCAAGATTGYCGGC

C (p.Val138Ala)

AAGTGGTAAGTCTCCTGGCCA′]

734
NM_018077.2(RBM28):
55131
RBM28
[′TCCTTTGACTCAGAAGAAGAAGAACYTGGG

c.1052T > C (p.Leu351Pro)

GAGCTTCTCCAACAGTTTGGA′]

735
NM_203395.2(IYD): c.347T > C
389434
IYD
[′AATGAGCAAGTCCCAATGGAAGTCAYTGAT

(p.Ile116Thr)

AATGTCATCAGAACGGCAGGT′]

736
NM_015702.2(MMADHC):
27249
MMADHC
[′CATTTAGGATTCTCTGTTGATGACCYTGGAT

c.776T > C (p.Leu259Pro)

GCTGTAAAGTGATTCGTCAT′]

737
NM_014165.3(NDUFAF4):
29078
NDUFAF4
[′AAAGATGAAAAGCTGCTGTCGTTTCYAAAA

c.194T > C (p.Leu65Pro)

GATGTGTATGTTGATTCCAAA′]

738
NM_001136271.2(NKX2-6):
137814
NKX2-6
[′GCAGGTGCTGGCCCTGGAGCGGCGCYTCAA

c.451T > C (p.Phe151Leu)

GCAGCAGCGGTACCTGTCAGC′]

739
NM_013319.2(UBIAD1):
29914
UBIAD1
[′TATCTACTTTGGAGGCCTGTCTGGCYCCTTT

c.511T > C (p.Ser171Pro)

CTCTACACAGGAGGTAAGAT′]

740
NM_001127628.1(FBP1):
2203
FBP1
[′TTGTCTAAAAAGGCCATCGGGGAGTYCATTT

c.581T > C (p.Phe194Ser)

TGGTGGACAAGGATGTGAAG′]

741
NM_000046.3(ARSB): c.349T > C
411
ARSB
[′TTTACAGCACCAAATAATCTGGCCCYGTCAG

(p.Cys117Arg)

CCCAGCTGTGTTCCTCTGGA′]

742
NM_000046.3(ARSB): c.707T > C
411
ARSB
[′TCTTTCCAGCCTCTGTTTCTCTACCYTGCTCT

(p.Leu236Pro)

CCAGTCTGTGCATGAGCCC′]

743
NM_000404.2(GLB1): c.152T > C
2720
GLB1
[′AAGGATGGCCAGCCATTTCGCTACAYCTCA

(p.Ile51Thr)

GGAAGCATTCACTACTCCCGT′]

744
NM_000404.2(GLB1): c.247T > C
2720
GLB1
[′AAGGGGCTGTGTGTGTCTTGGCAGGBATGTG

(p.Tyr83His)

CCCTGGAACTTTCATGAGCC′]

745
NM_024782.2(NHEJ1): c.367T >
79840
NHEJ1
[′CCTCCCCTTCTATTGGAATTTCCACYGCATG

C (p.Cys123Arg)

CTAGCTAGTCCTTCCCTGGT′]

746
NM_139241.3(FGD4): c.893T > C
121512
FGD4
[′CAGAAATTGGCACCATTCCTTAAGABGTATG

(p.Met298Thr)

GAGAATATGTGAAAGGATTT′]

747
NM_020631.4(PLEKHG5):
57449
PLEKHG5
[′TTGGGCCTTCCCTAACCAGGGTCCTYCCTCC

c.1940T > C (p.Phe647Ser)

TTATCTACCTGAATGAGTTT′]

748
NM_015559.2(SETBP1):
26040
SETBP1
[′GAGACGATCCCCAGCGACAGCGGCAYTGGG

c.2612T > C (p.Ile871Thr)

ACAGACAACAACAGCACTTCT′]

749
NM_138387.3(G6PC3): c.554T >
92579
G6PC3
[′CTCCTAGGCGCTGTCCTGGGCTGGCYGATGA

C (p.Leu185Pro)

CTCCCCGAGTGCCTATGGAG′]

750
NM_022489.3(INF2): c.556T > C
64423
INF2
[′CTTCAGCATTGTCATGAACGAGCTCYCCGGC

(p.Ser186Pro)

AGCGACAACGTGCCCTACGT′]

751
NM_022489.3(INF2): c.125T > C
64423
INF2
[′GACCCCGAGCTGTGCATCCGGCTGCYCCAG

(p.Leu42Pro)

ATGCCCTCTGTGGTCAACTAC′]

752
NM_018122.4(DARS2):
55157
DARS2
[′TTTGAAATTAAGAACTTCGTGAAGGBACCA

c.492+2T > C

ACCTCTGTTATTAATAAAATA′]

753
NM_015272.3(RPGRIP1L):
23322
RPGRIP1L
[′CCTTCATCCCGAATATAACTTCACTYCTCAA

c.1975T > C (p.Ser659Pro)

TATCTTGTTCATGTTAATGA′]

754
NM_001029871.3(RSPO4):
343637
RSPO4
[′CTTCAGCCAGGACTTCTGCATCCGGYGCAAG

c.319T > C (p.Cys107Arg)

AGGCAGTTTTACTTGTACAA′]

755
NM_000429.2(MAT1A): c.914T >
4143
MATIA
[′GCTGCCCGCTGGGTGGCCAAGTCTCYGGTG

C (p.Leu305Pro)

AAAGCAGGGCTCTGCCGGAGA′]

756
NM_032581.3(FAM126A):
84668
FAM126A
[′AACATTTTGTCTTTCTTCTAGTTGCBAGAAC

c.158T > C (p.Leu53Pro)

CTGTCTGTCACCAGCTCTTT′]

757
NM_006364.2(SEC23A):
10484
SEC23A
[′GGGTGATTCTTTCAATACTTCCTTAYTCAAA

c.1144T > C (p.Phe382Leu)

CAAACTTTTCAAAGAGTCTT′]

758
NM_018006.4(TRMU): c.229T >
55687
TRMU
[′CCATCAAGTGTCCTACGTAAAGGAGYATTG

C (p.Tyr77His)

GAATGATGTGTTCAGGTGAGT′]

759
NM_001174089.1(SLC4A11):
83959
SLC4A11
[′CTGCAGGTGCTTCAGCTGCTGCTGCYGTGTG

c.2480T > C (p.Leu827Pro)

CCTTCGGCATGAGCTCCCTG′]

760
NM_001174089.1(SLC4A11):
83959
SLC4A11
[′AGTGACAGGGGTGCGGTACCAGCAGYCGTG

c.589T > C (p.Ser197Pro)

GCTCTGCATCATGTGAGTTGC′]

761
NM_148960.2(CLDN19):
149461
CLDN19
[′GCCCTGATGGTGGTGGCCGTGCTCCYGGGCT

c.269T > C (p.Leu90Pro)

TCGTGGCCATGGTCCTCAGC′]

762
NM_153704.5(TMEM67):
91147
TMEM67
[′AACACAGATGGTCAGACTTTTGAGAYTGCA

c.2498T > C (p.Ile833Thr)

ATTTCTAACCAGATGAGACAA′]

763
NM_153704.5(TMEM67):
91147
TMEM67
[′ACAGGTCTTTACTGGCTTATTTTCTYCAAAG

c.1769T > C (p.Phe590Ser)

TGAGTGAGTTTCTGAATTTT′]

764
NM_153704.5(TMEM67):
91147
TMEM67
[′AGAACGTTTTGTCACTTATGTTGGAHGTGCC

c.1843T > C (p.Cys615Arg)

TTTGCTCTGAAGGTAAGTTT′]

765
NM_153704.5(TMEM67):
91147
TMEM67
[′ACATCTTGTCAAGCTCTTGGAAATAYGTGTG

c.755T > C (p.Met252Thr)

TGATGAACATGAATTCTTAC′]

766
NM_017777.3(MKS1):
54903
MKS1
[′CCCCGTGCGCAACTTGCGCCTCCGGYAGTCG

c.80+2T > C

CACCGCCCCAGCCCCGAGGC′]

767
NM_001041.3(SI): c.1022T > C
6476
SI
[′AATTACATGCTCATTTACTTTAAGCYTGTTG

(p.Leu341Pro)

GACTACCAGCAATGCCAGCA′]

768
NM_001041.3(SI): c.1859T > C
6476
SI
[′ATGGAATGGTCTATAACTGGAATGCYGGAG

(p.Leu620Pro)

TTCAGTTTGTTTGGAATACCT′]

769
NM_015506.2(MMACHC):
25974
MMACHC
[′CACCCCAACCGACGCCCCAAGATCCYGGCC

c.347T > C (p.Leul16Pro)

CAGACAGCAGCCCATGTAGCT′]

770
NM_000190.3(HMBS): c.739T >
3145
HMBS
[′GCACGATCCCGAGACTCTGCTTCGCYGCATC

C (p.Cys247Arg)

GCTGAAAGGGCCTTCCTGAG′]

771
NM_000190.3(HMBS): c.242T >
3145
HMBS
[′GAGAAAAGCCTGTTTACCAAGGAGCYTGAA

C (p.Leu81Pro)

CATGCCCTGGAGAAGAATGAG′]

772
NM_000237.2(LPL): c.662T > C
4023
LPL
[′ACCAGAGGGTCCCCTGGTCGAAGCAYTGGA

(p.Ile221Thr)

ATCCAGAAACCAGTTGGGCAT′]

773
NM_000237.2(LPL): c.337T > C
4023
LPL
[′AGACTCCAATGTCATTGTGGTGGACYGGCTG

(p.Trp113Arg)

TCACGGGCTCAGGAGCATTA′]

774
NM_000237.2(LPL): c.755T > C
4023
LPL
[′AACATTGGAGAAGCTATCCGCGTGAYTGCA

(p.Ile252Thr)

GAGAGAGGACTTGGAGGTAAA′]

775
NM_000263.3(NAGLU):
4669
NAGLU
[′GCTGGGGCCAGGCCCCGCGGCCGACYTCTC

c.142T > C (p.Phe48Leu)

CGTGTCGGTGGAGCGCGCTCT′]

776
NM_000018.3(ACADVL):
37
ACADVL
[′GCGTGTGCTCCGAGATCTTCGCATCYTCCGG

c.1372T > C (p.Phe458Leu)

ATCTTTGAGGGGACAAATGA′]

777
NM_018105.2(THAP1): c.241T >
55145
THAP1
[′GAAAGAGAATGCTGTGCCCACAATAYTTCTT

C (p.Phe81Leu)

TGTACTGAGCCACATGACAA′]

778
NM_005908.3(MANBA):
4126
MANBA
[′AGACAAGAGTCGTCCTTTTATTACGYCCAGT

c.1513T > C (p.Ser505Pro)

CCTACAAATGGGGCTGAAAC′]

779
NM_000124.3(ERCC6):
2074
ERCC6
[′AAGCAGTTTTTGACAAATAGAGTGCYAAAA

c.2960T > C (p.Leu987Pro)

GACCCAAAACAAAGGCGGTTT′]

780
NM_014845.5(FIG4): c.122T > C
9896
FIG4
[′GAAACGAAATATCGTGTCTTGAAGAYTGAT

(p.Ile41Thr)

AGAACAGAACCAAAAGATTTG′]

781
NM_000787.3(DBH):
1621
DBH
[′GATGGGGACACTGCCTATTTTGCGGYGAGTC

c.339 + 2T > C

TCTCCTCCCTGCCAGCTCTC′]

782
NM_000102.3(CYP17A1):
1586
CYP17AI
[′TCTAAAGGCAACTCTAGACATCGCGYCCAA

c.316T > C (p.Ser106Pro)

CAACCGTAAGGGTATCGCCTT′]

783
NM_000102.3(CYP17A1):
1586
CYP17A1
[′GGCGCTGCATCACAATGAGAAGGAGYGGCA

c.1216T > C (p.Trp406Arg)

CCAGCCGGATCAGTTCATGCC′]

784
NM_000102.3(CYP17A1):
1586
CYP17A1
[′GAGATCCTGGCCCGCCAGGAGCTCTYCCTCA

c.1358T > C (p.Phe453Ser)

TCATGGCCTGGCTGCTGCAG′]

785
NM_152783.4(D2HGDH):
728294
D2HGDH
[′GGAGATGGTAACCTGCACCTCAATGYGACG

c.1331T > C (p.Val444Ala)

GCGGAGGCCTTCAGCCCCTCG′]

786
NM_000255.3(MUT): c.313T > C
4594
MUT
[′TCCTACCATGTATACCTTTAGGCCCYGGACC

(p.Trp105Arg)

ATCCGCCAGTATGCTGGTTT′]

787
NM_000411.6(HLCS): c.710T > C
3141
HLCS
[′CTGTACCAGAAGTTCATGGCCTATCYTTCTC

(p.Leu237Pro)

AGGGAGGGAAGGTGTTGGGC′]

788
NM_022132.4(MCCC2): c.499T >
64087
MCCC2
[′AATTGCCATGCAAAACAGGCTCCCCYGCAT

C (p.Cys167Arg)

CTACTTAGGCAAGTCACCAGA′]

789
NM_020166.4(MCCC1):
56922
MCCC1
[′CATTATGACCCCATGATTGCGAAGCYGGTCG

c.1310T > C (p.Leu437Pro)

TGTGGGCAGCAGATCGCCAG′]

790
NM_198578.3(LRRK2):
120892
LRRK2
[′ATTGCAAAGATTGCTGACTACGGCAYTGCTC

c.6059T > C (p.Ile2020Thr)

AGTACTGCTGTAGAATGGGG′]

791
NM_000022.2(ADA): c.320T > C
100
ADA
[′GAGGTGCGGTACAGTCCGCACCTGCYGGCC

(p.Leu107Pro)

AACTCCAAAGTGGAGCCAATC′]

792
NM_199242.2(UNC13D):
201294
UNC13D
[′CTGGCCGCCTCATTCAGCTCCCTGCYGACCT

c.1208T > C (p.Leu403Pro)

ACGGCCTCTCCCTCATCCGG′]

793
NM_152443.2(RDH12): c.523T >
145226
RDH12
[′CCCTGCACGGGTGGTTAATGTGTCCYCGGTG

C (p.Ser175Pro)

GCTCACCACATTGGCAAGAT′]

794
NM_020435.3(GJC2): c.857T > C
57165
GJC2
[′TGCCTGCTGCTCAACCTCTGTGAGAYGGCCC

(p.Met286Thr)

ACCTGGGCTTGGGCAGCGCG′]

795
NM_000159.3(GCDH): c.883T >
2639
GCDH
[′CTTCGGCTGCCTGAACAACGCCCGGYACGG

C (p.Tyr295His)

CATCGCGTGGGGCGTGCTTGG′]

796
NM_000920.3(PC): c.434T > C
5091
PC
[′CGGTTTATTGGGCCAAGCCCAGAAGBGGTC

(p.Val145Ala)

CGCAAGATGGGAGACAAGGTG′]

797
NM_207118.2(GTF2H5): c.62T >
404672
GTF2H5
[′GATCCTGCCATGAAGCAGTTTCTGCYGTACT

C (p.Leu21Pro)

TGGATGAGTCCAATGCCCTG′]

798
NM_005787.5(ALG3): c.211T > C
10195
ALG3
[′TCTTCTTCCAGACACAGAGATTGACYGGAA

(p.Trp71Arg)

GGCCTACATGGCCGAGGTAGA′]

799
NM_024514.4(CYP2R1):
120227
CYP2R1
[′GGCTATGATGTAGTAAAGGAATGCCYTGTTC

c.296T > C (p.Leu99Pro)

ATCAAAGCGAAATTTTTGCA′]

800
NM_017929.5(PEX26): c.2T > C
55670
PEX26
[′CTGGGCCTTGGACCCGGACTCGTTAYGAAG

(p.Met1Thr)

AGCGATTCTTCGACCTCTGCA′]

801
NM_017929.5(PEX26): c.134T >
55670
PEX26
[′CTTCTGGAGGAGGCGGCCGACCTCCYGGTG

C (p.Leu45Pro)

GTGCACCTGGACTTCCGGGCG′]

802
NM_213599.2(ANO5): c.1066T >
203859
ANO5
[′TGGTCAGATGATCATGTGCCCACTCBGTGAT

C (p.Cys356Arg)

CAAGTGTGTGATTATTGGAG′]

803
NM_022370.3(ROBO3):
64221
ROBO3
[′CCAGCTGGTGCAAGGTTTCCGGGTGHCTTGG

c.2113T > C (p.Ser705Pro)

AGGGTAGCAGGCCCTGAGGG′]

804
NM_022370.3(ROBO3): c.14T > C
64221
ROBO3
[′CTGGGTCGAGCCATGCTGCGCTACCYGCTGA

(p.Leu5Pro)

AAACGCTGCTGCAGATGAAC′]

805
NM_207352.3(CYP4V2):
285440
CYP4V2
[′GTATGTTTTTCTCTTCCTAAGGTAABTTTAAC

c.332T > C (p.Ile111Thr)

TAGTTCAAAGCAAATTGAC′]

806
NM_178857.5(RP1L1): c.2878T >
94137
RP1L1
[′GTCTCCAGAGGCTGTGGTCCGCGAAYGGCT

C (p.Trp960Arg)

GGACAACATTCCAGAAGAGCC′]

807
NM_018668.4(VPS33B): c.89T >
26276
VPS33B
[′GCTCGAGACCAGCTCATCTATCTGCYGGAGC

C (p.Leu30Pro)

AGGTCAGTGCTTGCCTGACG′]

808
NM_024006.5(VKORC1):
79001
VKORC1
[′CGGGATTACCGCGCGCTCTGCGACGYGGGC

c.134T > C (p. Val45Ala)

ACCGCCATCAGCTGTTCGCGC′]

809
NM_000551.3(VHL): c.334T > C
7428
VHL
[′TGGCACGGGCCGCCGCATCCACAGCHACCG

(p.Tyr112His)

AGGTACGGGCCCGGCGCTTAG′]

810
NM_000551.3(VHL): c.292T > C
7428
VHL
[′CAACTTCGACGGCGAGCCGCAGCCCYACCC

(p.Tyr98His)

AACGCTGCCGCCTGGCACGGG′]

811
NM_000551.3(VHL): c.188T > C
7428
VHL
[′GAGGCCGGGCGGCCGCGGCCCGTGCYGCGC

(p.Leu63Pro)

TCGGTGAACTCGCGCGAGCCC′]

812
NM_000551.3(VHL): c.488T > C
7428
VHL
[′GTGTATACTCTGAAAGAGCGATGCCYCCAG

(p.Leu163Pro)

GTTGTCCGGAGCCTAGTCAAG′]

813
NM_014874.3(MFN2): c.227T > C
9927
MFN2
[′CCCGTTACCACAGAAGAACAGGTTCBGGAC

(p.Leu76Pro)

GTCAAAGGTTACCTATCCAAA′]

814
NM_015046.5(SETX): c.1166T >
23064
SETX
[′AACATGTATGAAGAAATGGAAACATYAGCC

C (p.Leu389Ser)

AGTGTACTTCAGTCAGATATT′]

815
NM_005609.2(PYGM): c.1187T >
5837
PYGM
[′TGGCCGGTGCACCTCTTGGAGACGCYGCTGC

C (p.Leu396Pro)

CGCGGCACCTCCAGATCATC′]

816
NM_005609.2(PYGM): c.2392T >
5837
PYGM
[′CTTTGACCTGCAGAACCCAAGAGAGHGGAC

C (p.Trp798Arg)

GCGGATGGTGATCCGGAACAT′]

817
NM_213653.3(HFE2): c.842T > C
148738
HFE2
[′CATGTGGAGATCCAAGCTGCCTACAYTGGC

(p.Ile281Thr)

ACAACTATAATCATTCGGCAG′]

818
NM_213653.3(HFE2): c.238T > C
148738
HFE2
[′TGGAGGGGTGGGCTCTGGCGGCCTCBGTCG

(p.Cys80Arg)

AGCCCTCCGCTCCTATGCGCT′]

819
NM_213653.3(HFE2): c.302T > C
148738
HFE2
[′ACCGCCCGCACCTGCCGCGGGGACCYCGCC

(p.Leu101Pro)

TTCCATTCGGCGGTACATGGC′]

820
NM_000045.3(ARG1): c.32T > C
383
ARG1
[′GCCAAGTCCAGAACCATAGGGATTAYTGGA

(p.Ile11Thr)

GCTCCTTTCTCAAAGGGACAG′]

821
NM_032409.2(PINK1): c.1040T >
−1
—
[′GCCGCCATGATGCTGCTGCAGCTGCYGGAA

C (p.Leu347Pro)

GGCGTGGACCATCTGGTTCAA′]

822
NM_153006.2(NAGS): c.1289T >
−1
—
[′GCCAGGTACAACGCCGCCGCCATTCYGACC

C (p.Leu430Pro)

ATGGAGCCCGTCCTGGGGGGC′]

823
NM_153006.2(NAGS): c.1450T >
−1
—
[′CCGGGTCACCAACCCCATCAATCCCBGGTAG

C (p.Trp484Arg)

GTCCTGCCACTCCCAGCTCT′]

824
NM_001173464.1(KIF21A):
55605
KIF21A
[′AGTATTTCTGATTGTCAGGCCAACAYAATGC

c.3029T > C (p.Ile1010Thr)

AGATGGAAGAAGCAAAGGTT′]

825
NM_001173464.1(KIF21A):
55605
KIF21A
[′GTCAGCCCTTCAGACAGAGACTTTAYGGAA

c.1067T > C (p.Met356Thr)

ACGTTAAACACCCTGAAATAC′]

826
NM_000434.3(NEU1): c.1088T >
4758
NEU1
[′TCATGGCGGAAAGAGACAGTCCAGCYATGG

C (p.Leu363Pro)

CCAGGCCCCAGTGGCTATTCA′]

827
NM_000434.3(NEU1): c.718T > C
4758
NEU1
[′CCTCAGCGATGATCATGGTGCCTCCYGGCGC

(p.Trp240Arg)

TACGGAAGTGGGGTCAGCGG′]

828
NM_000026.2(ADSL): c.1312T >
158
ADSL
[′TGATGCCTACTTCAGTCCCATTCACYCCCAG

C (p.Ser438Pro)

TTGGATCATTTACTGGATCC′]

829
NM_000026.2(ADSL): c.674T > C
158
ADSL
[′TCCAAGGTAGAGCAGCTTGACAAGAYGGTG

(p.Met225Thr)

ACAGAAAAGGCAGGATTTAAG′]

830
NM_018400.3(SCN3B): c.29T > C
55800
SCN3B
[′CCTGCCTTCAATAGATTGTTTCCCCYGGCTT

(p.Leu10Pro)

CTCTCGTGCTTATCTACTGG′]

831
NM_024577.3(SH3TC2):
79628
SH3TC2
[′CCTTCCTGTATCAGGAGTCCCAGGTRTATTG

c.505T > C (p.Tyr169His)

TTTCCAGGTGTTTATCATCT′]

832
NM_000243.2(MEFV): c.2177T >
4210
MEFV
[′GTGGGCATCTTCGTGGACTACAGAGHTGGA

C (p.Val726Ala)

AGCATCTCCTTTTACAATGTG′]

833
NM_000483.4(APOC2): c.142T >
−1
—
[′GGTGAAGGAATCTCTCTCCAGTTACYGGGA

C (p.Trp48Arg)

GTCAGCAAAGACAGCCGCCCA′]

834
NM_058172.5(ANTXR2):
118429
ANTXR2
[′CTCTTCTTTCTAAAGCTTGAAAGAAYTGCTG

c.566T > C (p.Ile189Thr)

ATTCCAAGGAGCAAGTTTTC′]

835
NM_001128085.1(ASPA):
−1
—
[′TCAGACTTCTCTGGCTCCACTACCCYGCTAC

c.454T > C (p.Cys152Arg)

GTTTATCTGATTGAGCATCC′]

836
NM_022464.4(SIL1):
64374
SIL1
[′TGACTTATGGACGAAGAAATACAGTRCCTG

c.645 + 2T > C

ATGGACATAATATTCAAGATC′]

837
NM_001037633.1(SIL1):
64374
SIL1
[′CTGCTGGGCTCTGTCAACAGCTTGCYGAAGG

c.1370T > C (p.Leu457Pro)

AGCTGAGATGAGGCCCCACA′]

838
NM_000391.3(TPP1): c.1093T > C
1200
TPP1
[′TCTCTCAGGTGACAGTGGGGCCGGGYGTTG

(p.Cys365Arg)

GTCTGTCTCTGGAAGACACCA′]

839
NM_182760.3(SUMF1):
285362
SUMF1
[′AGTGAAGAAAGGTGGATCCTACATGYGCCA

c.1006T > C (p.Cys336Arg)

TAGGGTAAGTCATGTCACTAA′]

840
NM_182760.3(SUMF1): c.463T >
285362
SUMF1
[′CTTATAGGCTGAGAAGTTTGGCGACYCCTTT

C (p.Ser155Pro)

GTCTTTGAAGGCATGTTGAG′]

841
NM_177986.3(DSG4): c.574T > C
−1
—
[′TGCAGATGAAGAAAATCATCTGAATHCTAA

(p.Ser192Pro)

AATTGCCTACAAGATCGTCTC′]

842
NM_004183.3(BEST1): c.253T >
7439
BEST1
[′CCCCCGCCCCTCCTGCCCAGGCTTCYACGTG

C (p.Tyr85His)

ACGCTGGTCGTGACCCGCTG′]

843
NM_004183.3(BEST1): c.122T >
7439
BEST1
[′TATGGCGAGTTCTTAATCTTCCTGCYCTGCT

C (p.Leu41Pro)

ACTACATCATCCGCTTTATT′]

844
NM_004183.3(BEST1): c.614T >
7439
BEST1
[′CTTGGAGGTCGAATCCGGGACCCTAYCCTGC

C (p.Ile205Thr)

TCCAGAGCCTGCTGAACGTG′]

845
NM_004183.3(BEST1): c.704T >
7439
BEST1
[′TACGACTGGATTAGTATCCCACTGGYGTATA

C (p.Val235Ala)

CACAGGTGAGGACTAGGCTG′]

846
NM_024312.4(GNPTAB):
79158
GNPTAB
[′TGTTTGTTGTTGTTAAAAGGATGTTYTTCGA

T c.1120> C (p.Phe374Leu)

AATTTGAGCCACTTGCCTAC′]

847
NM_000158.3(GBE1): c.671T > C
2632
GBE1
[′TATAAACATTTTACATGCAATGTACYACCAA

(p.Leu224Pro)

GAATCAAAGGCCTTGGTAAG′]

848
NM_017890.4(VPS13B):
157680
VPS13B
[′CAGGTGCCATCTTCAAACAGTTCCAYTATTT

c.8459T > C (p.Ile2820Thr)

ATGTCTGGTGCACAGTTTTG′]

849
NM_000019.3(ACAT1): c.935T >
38
ACAT1
[′CTCAATGTTACACCACTGGCAAGAAYAGTA

C (p.Ile312Thr)

GGTAAGGCCAGGCGAGGTGGC′]

850
NM_020184.3(CNNM4):
26504
CNNM4
[′CTCAGTTTTCCCATTAGCAAGCTCCYGGACT

c.971T > C (p.Leu324Pro)

TTTTTCTGGGCCAGGAGATT′]

851
NM_001171507.2(MCFD2):
90411
MCFD2
[′GATGACAAGAACAATGATGGATACAYTGAC

c.407T > C (p.Ile136Thr)

TATGCTGAATTTGCAAAATCA′]

852
NM_174936.3(PCSK9): c.646T >
255738
PCSK9
[′TGTGCCCGAGGAGGACGGGACCCGCYTCCA

C (p.Phe216Leu)

CAGACAGGTAAGCACGGCCGT′]

853
NM_000419.3(ITGA2B):
3674
ITGA2B
[′GACTTCCGGGACAAGCTGAGCCCCAYTGTG

Tc.1787 > C (p.Ile596Thr)

CTCAGCCTCAATGTGTCCCTA′]

854
NM_000419.3(ITGA2B):
3674
ITGA2B
[′CCCTTCCAGGCCGGAGAGCTGGTGCYTGGG

c.641T > C (p.Leu214Pro)

GCTCCTGGCGGCTATTATTTC′]

855
NM_004817.3(TJP2): c.143T > C
9414
TJP2
[′TCCAAAAGAGGATTTGGAATTGCAGYGTCC

(p.Val48Ala)

GGAGGCAGAGACAACCCCCAC′]

856
NM_173477.4(USH1G): c.143T >
124590
USH1G
[′GCCTACCATGGCAACCTCGAGTCGCYGCGTC

C (p.Leu48Pro)

TCATTGTGAGCCGCGGGTGA′]

857
NM_000271.4(NPC1): c.3182T >
4864
NPC1
[′GACGCTCTGAAGAAAGCCCGACTTAYAGCC

C (p.Ile1061Thr)

AGTAATGTCACCGAAACCATG′]

858
NM_000271.4(NPC1): c.1133T >
4864
NPC1
[′TTTGTCCGGGTCACAACCAATCCAGYTGACC

C (p.Val378Ala)

TCTGGTCAGCCCCCAGCAGC′]

859
NM_000271.4(NPC1): c.337T > C
4864
NPC1
[′ACTGAACCTGTTTTGTGAGCTGACAYGTAGC

(p.Cys113Arg)

CCTCGACAGAGTCAGTTTTT′]

860
NM_000543.4(SMPD1): c.911T >
6609
SMPD1
[′CGGGCCCTGACCACCGTCACAGCACYTGTG

C (p.Leu304Pro)

AGGAAGTTCCTGGGGCCAGTG′]

861
NM_000226.3(KRT9): c.503T > C
3857
KRT9
[′CTCAATTCTCGGCTGGCCTCTTACTYGGATA

(p.Leu168Ser)

AGGTGCAGGCTCTAGAGGAG′]

862
NM_000226.3(KRT9): c.470T > C
3857
KRT9
[′CTGACTGCTAATGAGAAGAGCACCANGCAG

(p.Met157Thr)

GAACTCAATTCTCGGCTGGCC′]

863
NM_000051.3(ATM): c.7967T > C
−1
—
[′CCAGCAGACCAGCCAATTACTAAACYTAAG

(p.Leu2656Pro)

AATTTAGAAGATGTTGTTGTC′]

864
NM_000487.5(ARSA): c.410T > C
410
ARSA
[′GGGGTGGGGCCTGAGGGGGCCTTCCYGCCC

(p.Leu137Pro)

CCCCATCAGGGCTTCCATCGA′]

865
NM_017653.3(DYM): c.1624T >
54808
DYM
[′AATGATGTTAGAGATCATCAACTCCYGCCTG

C (p.Cys542Arg)

ACAAATTCCCTTCACCACAA′]

866
NM_016038.2(SBDS):
51119
SBDS
[′GACCAAACTGAAATCTGTAAGCAGGYGGGT

c.258 + 2T > C

AACAGCTGCAGCATAGCTAAC′]

867
NM_001079802.1(FKTN):
2218
FKTN
[′ACTCATGCGATCCACTTGGTAGTCTYTCATG

c.527T > C (p.Phe176Ser)

AGAGGAGTGGCAACTACCTC′]

868
NM_013382.5(POMT2):
29954
POMT2
[′GGCAGGACTAAGGTGGCTGGACTCAYGGGA

c.2242T > C (p.Trp748Arg)

CTTTTGAGGCCACTGCAAAGA′]

869
NM_024529.4(CDC73): c.191T >
79577
CDC73
[′ACATTGGATTCCATTTTATTTCTACYTAATA

C (p.Leu64Pro)

ACGTGCACCTTTCTCATCCT′]

870
NM_000268.3(NF2): c.1079T > C
4771
NF2
[′ACGAGGGATGAGTTGGAGAGGAGGCYGCTG

(p.Leu360Pro)

CAGATGAAAGAAGAAGCAACA′]

871
NM_000268.3(NF2): c.1604T > C
4771
NF2
[′GAATACATGGAAAAGAGCAAGCATCYGCAG

(p.Leu535Pro)

GAGCAGCTCAATGAACTCAAG′]

872
NM_000268.3(NF2): c.185T > C
4771
NF2
[′CTGGGGCTCCGAGAAACCTGGTTCTYTGGAC

(p.Phe62Ser)

TGCAGTACACAATCAAGGAC′]

873
NM_139248.2(LIPH): c.322T > C
200879
LIPH
[′AGACATGAACGTAGTTGTTGTTGATYGGAAT

(p.Trp108Arg)

CGAGGAGCTACAACTTTAAT′]

874
NM_015102.4(NPHP4):
261734
NPHP4
[′GCCACGCTGGGGGTCGCCGAGTTCTYTGAGT

c.2972T > C (p.Phe991Ser)

TTGTGCTTAAGAACCCCCAC′]

875
NM_024105.3(ALG12): c.473T >
79087
ALG12
[′ACCCTCCCGCACTGTCTTGCAGTCCYGCTGG

C (p.Leu158Pro)

CCCTCGCGGCCTGGCTGCGG′]

876
NM_000280.4(PAX6): c.773T > C
5080
PAX6
[′GTCCCACCTGATTTCCAGGTATGGTYTTCTA

(p.Phe258Ser)

ATCGAAGGGCCAAATGGAGA′]

877
NM_024426.4(WT1): c.1351T > C
7490
WT1
[′CTCTGTCCATTTAGGTGTGAAACCAYTCCAG

(p.Phe451Leu)

TGTAAAACTTGTCAGCGAAA′]

878
NM_024426.4(WT1): c.1378T > C
7490
WT1
[′CCAGTGTAAAACTTGTCAGCGAAAGYTCTCC

(p.Phe460Leu)

CGGTCCGACCACCTGAAGAC′]

879
NM_005957.4(MTHFR): c.968T >
4524
MTHFR
[′GTGCCAGGCCTCCACTTCTACACCCYCAACC

C (p.Leu323Pro)

GCGAGATGGCTACCACAGAG′]

880
NM_016247.3(IMPG2): c.370T >
50939
IMPG2
[′TCACGCCCAGGAAGTCGATCCCAAARAGTC

C (p.Phe124Leu)

CTGAAGGCTTCCCAGACAGCT′]

881
NM_002225.3(IVD): c.134T > C
3712
IVD
[′CCCGTGGACGATGCAATCAATGGGCYAAGC

(p.Leu45Pro)

GAGGAGCAGAGGCAGGTGAGG′]

882
NM_001127328.2(ACADM):
34
ACADM
[′CAGTTAGCTACTGATGCTGTGCAGAYACTTG

c.1136T > C (p.Ile379Thr)

GAGGCAATGGATTTAATACA′]

883
NM_001127328.2(ACADM):
34
ACADM
[′TTAGGAATTAAACATGGGCCAGCGAYGTTC

c.742T > C (p.Cys248Arg)

AGATACTAGAGGAATTGTCTT′]

884
NM_000016.5(ACADM):
34
ACADM
[′GGAAATCATCCCAGTGGCTGCAGAAYATGA

c.199T > C (p.Tyr67His)

TAAAACTGGTGAAGTAGGTAT′]

885
NM_000155.3(GALT): c.221T > C
2592
GALT
[′CCCCGCCATGACCCTCTCAACCCTCBGTGTC

(p.Leu74Pro)

CTGGGGCCATCCGAGCCAAC′]

886
NM_000155.3(GALT): c.512T > C
2592
GALT
[′CTCCGTATCCCTATCTGATAGATCTYTGAAA

(p.Phe171Ser)

ACAAAGGTGCCATGATGGGC′]

887
NM_000155.3(GALT): c.580T > C
2592
GALT
[′CCCTTGACAGGTATGGGCCAGCAGTYTCCTG

(p.Phe194Leu)

CCAGATATTGCCCAGCGTGA′]

888
NM_000250.1(MPO): c.752T > C
4353
MPO
[′ACTCCGGACCAGGAGCGCTCACTCAYGTTC

(p.Met251Thr)

ATGCAATGGGGCCAGCTGTTG′]

889
NM_020247.4(ADCK3):
56997
ADCK3
[′CTCAGCCAGGAGATTCGGAACGAGGYTTGT

c.1398 + 2T > C

CTGTGCCAGCAGACAGGTGGG′]

890
NM_000229.1(LCAT): c.508T > C
3931
LCAT
[′GACTGTGCGCGCCGCCCCCTATGACYGGCG

(p.Trp170Arg)

GCTGGAGCCCGGTGAGTGTCT′]

891
NM_000229.1(LCAT): c.698T > C
3931
LCAT
[′CGCTTTATTGATGGCTTCATCTCTCYTGGGG

(p.Leu233Pro)

CTCCCTGGGGTGGCTCCATC′]

892
NM_000229.1(LCAT):
3931
LCAT
[′CAGGTGCCCCAGACCCCAGCTGCCCYGACC

c.524 − 22T > C

CCTTCCACCCGCTGCAGGCCA′]

893
NM_000403.3(GALE): c.548T > C
2582
GALE
[′CCACAGACTTGGAACGCAGTGCTGCYGCGC

(p.Leu183Pro)

TATTTCAACCCCACAGGTGCC′]

894
NM_000527.4(LDLR):
3949
LDLR
[′ACAAATCTGACGAGGAAAACTGCGGYATGG

c.694 + 2T > C

GCGGGGCCAGGGTGGGGGCGG′]

895
NM_000375.2(UROS): c.217T > C
7390
UROS
[′CAGAGCAGTGGAAGCAGCAGAGTTAYGTTT

(p.Cys73Arg)

GGAGCAAAACAATAAAACTGA′]

896
NM_000375.2(UROS):
7390
UROS
[′GCTAACATGCTCTTTCTTGGCCTTAYCAGTG

c.−26 − 177T > C

ACAGGGGTCTTCAGAAAGAA′]

897
NM_000372.4(TYR): c.265T > C
7299
TYR
[′GCCTTCCGTCTTTTATAATAGGACCYGCCAG

(p.Cys89Arg)

TGCTCTGGCAACTTCATGGG′]

898
NM_000017.3(ACADS): c.529T >
35
ACADS
[′CACCGCCCGGGCCGAGGGCGACTCABGGGT

C (p.Trp177Arg)

TCTGAATGGAACCAAAGCCTG′]

899
NM_000053.3(ATP7B):
540
ATP7B
[′GCGCCTCAGCCACTCACGGTTTCCARTCAGC

c.3443T > C (p.Ile1148Thr)

ACAGAGAAGGTCTGGGGGAC′]

900
NM_000053.3(ATP7B):
540
ATP7B
[′GCCTTCACTGTCCTTGTCTTTCAGCYCCTCG

c.2123T > C (p.Leu708Pro)

GTGGGTGGTACTTCTACGTT′]

901
NM_000520.4(HEXA): c.1453T >
3073
HEXA
[′AGCAGGGGCTGTTGCCGAAAGGCTGYGGAG

C (p.Trp485Arg)

CAACAAGTTGACATCTGACCT′]

902
NM_000520.4(HEXA): c.632T > C
3073
HEXA
[′TGGCATCTGGTAGATGATCCTTCCTYCCCAT

(p.Phe211Ser)

ATGAGAGCTTCACTTTTCCA′]

903
NM_000520.4(HEXA): c.538T > C
3073
HEXA
[′CTTGCTGTTGGATACATCTCGCCATYACCTG

(p.Tyr180His)

CCACTCTCTAGCATCCTGGA′]

904
NM_016335.4(PRODH):
5625
PRODH
[′CTGGGCCAGGTATGCGCCCCGCACCRGCTTG

c.1322T > C (p.Leu441Pro)

GCCCCAAAACACCAGCCCTC′]

905
NM_000152.3(GAA): c.953T > C
2548
GAA
[′GTGTTCCTGCTAAACAGCAATGCCAYGGGT

(p.Met318Thr)

AAGCTGCCCGCCGCCCAGCGC′]

906
NM_012213.2(MLYCD):
23417
MLYCD
[′GCGGCCGGCGCCCTGGAGCGGGCCAYGGAC

c.119T > C (p.Met40Thr)

GAGCTGCTGCGCCGCGCGGTG′]

907
NM_012464.4(TLL1): c.713T > C
7092
TLL1
[′AAGAACTGTGATAAATTTGGGATTGYTGTTC

(p.Val238Ala)

ATGAATTGGGTCATGTGATA′]

908
NM_000112.3(SLC26A2):
1836
SLC26A2
[′CCTGCAGCGGCCCGGACCCGAGAGGYGAGA

c.−26 + 2T > C

AGAGGGAAGCGGACCAGGGAA′]

909
NM_138691.2(TMC1): c.1543T >
117531
TMC1
[′CCCTGCAGATGTACCTCGAGGACCTYGCTGG

C (p.Cys515Arg)

GAAACAATGGTGGGACAGGT′]

910
NM_138694.3(PKHD1):
5314
PKHD1
[′GTTGTCCTACAAGGAGAGGAGCCCAYTGAA

c.10658T > C (p.Ile3553Thr)

ATACGCTCAGGTGTTTCCATT′]

911
NM_001034116.1(EIF2B4):
8890
EIF2B4
[′TGCAGATGACCCTGATGATCTGCAAYGTAA

c.1393T > C (p.Cys465Arg)

GCGGGGAGAACATGTTGCGCT′]

912
NM_001034116.1(EIF2B4):
8890
EIF2B4
[′ATCCCTACGGTTGTTGAATCTAGTCYATGAT

c.1465T > C (p.Tyr489His)

GTGACTCCCCCAGAGCTTGT′]

913
NM_018960.4(GNMT): c.149T >
27232
GNMT
[′ACCGCCGAGTACAAGGCATGGCTGCYTGGG

C (p.Leu50Pro)

CTGCTGCGCCAGCACGGCTGC′]

914
NM_181457.3(PAX3): c.268T > C
5077
PAX3
[′CTGCGTCTCCAAGATCCTGTGCAGGYACCAG

(p.Tyr90His)

GAGACTGGCTCCATACGTCC′]

915
NM_024301.4(FKRP): c.899T > C
79147
FKRP
[′GAGACCACGCGCTGCTTCGGAACCGYGGTG

(p.Val300Ala)

GGCGACACGCCCGCCTACCTC′]

916
NM_021020.3(LZTS1): c.85T > C
11178
LZTS1
[′TTCGCAGTACAAGCTGCGCAAGTCCYCCCAC

(p.Ser29Pro)

CTCAAGAAGCTCAACCGGTA′]

917
NM_005857.4(ZMPSTE24):
10269
ZMPSTE24
[′TGTACTAGGCCATGAACTGGGGCACYGGAA

c.1018T > C (p.Trp340Arg)

GTTGGGACATACAGTCAAAAA′]

918
NM_017838.3(NHP2): c.415T > C
55651
NHP2
[′GCCCCATGAGGAGTACCAGGAGGCTYACGA

(p.Tyr139His)

TGAGTGCCTGGAGGAGGTGCA′]

919
NM_000157.3(GBA): c.1448T > C
2629
GBA
[′GGGATGCATCAGTGCCACTGCGTCCVGGTC

(p.Leu483Pro)

GTTCTTCTGACTGGCAACCAG′]

920
NM_001005741.2(GBA):
2629
GBA
[′CATCTACCACCAGACCTGGGCCAGAYACTTT

c.751T > C (p.Tyr251His)

GTGAAGTAAGGGATCAGCAA′]

921
NM_001243133.1(NLRP3):
114548
NLRP3
[′AAATTCGAAAAGGGGTATTTGATTTYTGTTG

c.1718T > C (p.Phe573Ser)

TACGTTTCCTCTTTGGCCTG′]

922
NM_001243133.1(NLRP3):
114548
NLRP3
[′GGCTTCGATGAGCTGCAAGGTGCCTYTGAC

c.926T > C (p.Phe309Ser)

GAGCACATAGGACCGCTCTGC′]

923
NM_001243133.1(NLRP3):
114548
NLRP3
[′CTCATCACCACGAGACCTGTGGCCCYGGAG

c.1058T > C (p.Leu353Pro)

AAACTGCAGCACTTGCTGGAC′]

924
NM_057176.2(BSND): c.35T > C
7809
BSND
[′GAGAAGACCTTCCGGATCGGCTTCAYTGTGC

(p.Ile12Thr)

TGGGGCTTTTCCTGCTGGCC′]

925
NM_001195794.1(CLRN1):
7401
CLRN1
[′TCTGTTGCAGGCTCCTGTGGCTGTCYTGTCA

c.488T > C (p.Leu163Pro)

TGATATTGTTTGCCTCTGAA′]

926
NM_175073.2(APTX): c.668T > C
54840
APTX
[′GCTGTGGCCAGGGAACACCTTGAACYCCTT

(p.Leu223Pro)

AAGCATATGCACACTGTGGGG′]

927
NM_020365.4(EIF2B3):
8891
EIF2B3
[′CCACCAGTCCATTCGTCAGCCCAGAYTGTCA

c.1037T > C (p.Ile346Thr)

GCAAACACCTGGTAAGTGCT′]

928
NM_031433.3(MFRP): c.545T > C
−1
—
[′ATCCAGGTGGCCACAGACCATGCAAYACAG

(p.Ile182Thr)

CTCAAGATCGAAGCCCTCAGC′]

929
NM_016180.4(SLC45A2):
51151
SLC45A2
[′AGTGCACACAACTCCACAGAGTTTCYCATCT

c.1082T > C (p.Leu361Pro)

ACGAAAGAGGAGTCGAGGTT′]

930
NM_006005.3(WFS1): c.2486T >
7466
WFS1
[′AGCCTCATCGAGTTCAGCACCATCCYGGAG

C (p.Leu829Pro)

GGCCGCCTGGGCAGCAAGTGG′]

931
NM_024960.4(PANK2): c.178T >
80025
PANK2
[′GATCAAAGGAATTTTATACATTGACYCAGTC

C (p.Ser60Pro)

GGATTCAATGGACGGTCACA′]

932
NM_024960.4(PANK2): c.437T >
80025
PANK2
[′ACCACTTTTGAAGAAGCTCTTGAAAYGGCAT

C (p.Met146Thr)

CTCGTGGAGATAGCACCAAA′]

933
NM_020427.2(SLURP1): c.43T >
57152
SLURP1
[′TGTGCAGCTGCTGCTCGTGGCAGCCYGGAG

C (p.Trp15Arg)

CATGGGCTGTGGTGAGTGGGC′]

934
NM_020427.2(SLURP1):
57152
SLURP1
[′GGTGACCCGCTCCTGCTCCAGCTCCYGTGTG

c.229T > C (p.Cys77Arg)

GCCACCGACCCCGACAGCAT′]

935
NM_021830.4(C10orf2):
56652
C10orf2
[′CTTCGGGAGGAGGTGCTAGGAGAACBGTCA

c.1142T > C (p.Leu381Pro)

AATGTGGAGCAAGCAGCTGGC′]

936
NM_001033855.2(DCLREIC):
64421
DCLREIC
[′CCGGACTCTGGGATCGGCGGCGCTAYGAGT

c.2T > C (p.Met1Thr)

TCTTTCGAGGGGCAGATGGCC′]

937
NM_153741.1(DPM3): c.254T > C
54344
DPM3
[′CAGATACAGGAGGCCCGAGCCGACTYAGCC

(p.Leu85Ser)

CGCAGGGGGCTGCGCTTCTGA′]

938
NM_000441.1(SLC26A4):
5172
SLC26A4
[′GCCTTCCAAGTGCTGGTCTCACAGCYAAAG

c.707T > C (p.Leu236Pro)

ATTGTCCTCAATGTTTCAACC′]

939
NM_000441.1(SLC26A4):
5172
SLC26A4
[′TGGAAGCATCCCTAGCACAGATATCYACAA

Tc.1588 > C (p.Tyr530His)

AAGTACCAAGAATTACAAAAA′]

940
NM_000441.1(SLC26A4):
−1
—
[′CTTTCCCTTCGACCAAGGTGTCTGTYGCTCC

c.−103T > C

GTAAATAAAACGTCCCACTG′]

941
NM_000441.1(SLC26A4):
5172
SLC26A4
[′ATTTTTCACTTAAAAACTCACTAGGHTTTTG

c.1003T > C (p.Phe335Leu)

CCTCCTGAACTTCCACCTGT′]

942
NM_022458.3(LMBR1):
64327
LMBR1
[′AACAAAGATTTTTTTAATATGTTTCYATCCT

c.423 + 4842T > C

GTGTCACAGTTTGAAATTGT′]

943
NM_022458.3(LMBR1):
64327
LMBR1
[′AAAGCTGAGCAACATGACAGCACAAYAGAG

c.423 + 4808T > C

GAGGAACAAAGATTTTTTTAA′]

944
NM_145693.2(LPIN1):
23175
LPIN1
[′GCGACCACCGGGAGATCACGAAAGGYACCG

c.1441 + 2T > C

CGGGCCTCGCGCGGGCGCCCT′]

945
NM_022124.5(CDH23):
64072
CDH23
[′AGTGGCTGCAATGCACGCCTCACCTYCAAC

c.5663T > C (p.Phe1888Ser)

ATCACTGCGGGCAACCGCGAG′]

946
NM_153212.2(GJB4): c.409T > C
127534
GJB4
[′GTGGACGTACTTGCTGAGCCTCATCYTCAAG

(p.Phe137Leu)

GCCGCCGTGGATGCTGGCTT′]

947
NM_021044.2(DHH): c.2T > C
50846
DHH
[′TTTTGGCCGAGGTCCGCTGTATCCAYGGCTC

(p.Met1Thr)

TCCTGACCAATCTACTGCCC′]

948
NM_021044.2(DHH): c.485T > C
50846
DHH
[′CGCGACCGCAACAAGTATGGGTTGCYGGCG

(p.Leu162Pro)

CGCCTCGCAGTGGAAGCCGGC′]

949
NM_020638.2(FGF23): c.287T >
8074
FGF23
[′GTGATGAGCAGAAGATACCTCTGCAYGGAT

C (p.Met96Thr)

TTCAGAGGCAACATTTTTGGA′]

950
NM_022041.3(GAN): c.1268T > C
8139
GAN
[′TGCTATGCAGCTATGAAAAAGAAAAYCTAC

(p.Ile423Thr)

GCCATGGGTGGAGGCTCCTAC′]

951
NM_015665.5(AAAS): c.787T > C
8086
AAAS
[′CAGTGGGGGGCGGCTGCTCTCAGCTYCACC

(p.Ser263Pro)

CGTGGATGCTGCTATCCGGGT′]

952
NM_021615.4(CHST6): c.827T >
4166
CHST6
[′TACCGCCTGGTGCGCTTCGAGGACCYGGCG

C (p.Leu276Pro)

CGGGAGCCGCTGGCAGAAATC′]

953
NM_000368.4(TSC1): c.539T > C
7248
TSC1
[′GTGGCGGAAGTCTATCTCGTCCATCYCCATG

(p.Leu180Pro)

CCAGTGTGTACGCACTCTTT′]

954
NM_020661.2(AICDA): c.238T >
57379
AICDA
[′CCCTGGCCGCTGCTACCGCGTCACCYGGTTC

C (p.Trp80Arg)

ACCTCCTGGAGCCCCTGCTA′]

955
NM_020661.2(AICDA): c.317T >
57379
AICDA
[′CTGCGAGGGAACCCCAACCTCAGTCYGAGG

C (p.Leu106Pro)

ATCTTCACCGCGCGCCTCTAC′]

956
NM_020661.2(AICDA): c.452T >
57379
AICDA
[′GATTATTTTTACTGCTGGAATACTTYTGTAG

C (p.Phe151Ser)

AAAACCACGAAAGAACTTTC′]

957
NM_020632.2(ATP6V0A4):
50617
ATP6V0A4
[′ATCATTCTGCAATTTATCCCTGAGAYGATTT

c.1739T > C (p.Met580Thr)

TTATCCTGTGTCTGTTTGGA′]

958
NM_054027.4(ANKH): c.143T >
56172
ANKH
[′GCTGTCAAGGAGGATGCAGTCGAGAYGCTG

C (p.Met48Thr)

GCCAGCTACGGGCTGGCGTAC′]

959
NM_054027.4(ANKH): c.1015T >
56172
ANKH
[′TGTTTGATGTCTTTCTCCCCAGCTCYGTTTCG

C (p.Cys339Arg)

TGATGTTTTGGACACCCAA′]

960
NM_054027.4(ANKH): c.1172T >
−1
—
[′GTGAGGGCGCATCTCACCGGGTGGCYGATG

C (p.Leu391Pro)

ACACTGAAGAAAACCTTCGTC′]

961
NM_016373.3(WWOX): c.872T >
51741
WWOX
[′ACAAAAAACGACTATTGGGCGATGCYGGCT

C (p.Leu291Pro)

TATAACAGGTCCAAGCTCTGC′]

962
NM_021102.3(SPINT2):
10653
SPINT2
[′CAGCGGATTCCTCTGTCCCAAGTGGYAGGTT

c.337 + 2T > C

CTTAAAGAGACCCGCGATGG′]

963
NM_014588.5(VSX1): c.50T > C
30813
VSX1
[′GACGGGCGCACTAGCAGCAGGGCGCYGGTG

(p.Leu17Pro)

CCTGGCGGTTCCCCTAGGGGC′]

964
NM_006946.2(SPTBN2):
6712
SPTBN2
[′GAAAAGGAACTGGGACTTACCAAGCYGCTG

c.758T > C (p.Leu253Pro)

GATCCCGAAGGTGGGGCCAGA′]

965
NM_012452.2(TNFRSF13B):
23495
TNFRSF13B
[′GCACCCTAAGCAATGTGCATACTTCYGTGAG

c.310T > C (p.Cys104Arg)

AACAAGCTCAGGAGCCCAGT′]

966
NM_170784.2(MKKS): c.830T >
8195
MKKS
[′GAAAATGCAGTCTTGGACCAGCTGCYTAAC

C (p.Leu277Pro)

CTAGGAAGGCAGCTAATCAGT′]

967
NM_015717.4(CD207): c.790T >
50489
CD207
[′AATGGCGTGTCATCCACCCAGGACCRGTCCC

C (p.Trp264Arg)

CTTCCATCCCTGCTTTAGTC′]

968
NM_153717.2(EVC): c.919T > C
2121
EVC
[′TGTGGAAAAGAAGGAGAGAGAATACYCTGA

(p.Ser307Pro)

ACAGCTAATCGATAATGTGCG′]

969
NM_014384.2(ACAD8): c.455T >
27034
ACAD8
[′AAATTTTGCCCACCGCTCTGTACCAYGGAGA

C (p.Met152Thr)

AGTTTGCTTCCTACTGCCTC′]

970
NM_004924.4(ACTN4): c.784T >
81
ACTN4
[′CGAGAAGGCCATAATGACCTATGTGYCCAG

C (p.Ser262Pro)

CTTCTACCATGCCTTTTCAGG′]

971
NM_005097.3(LGI1): c.136T > C
9211
LGI1
[′AGCGAAGCCAAAATGCCCTGCCGTGYGTAC

(p.Cys46Arg)

TTGTACCAAAGATAATGCTTT′]

972
NM_005097.3(LGI1): c.695T > C
9211
LGI1
[′GCAGAATTTGCAAAGTCTCAAGACCYGCCTT

(p.Leu232Pro)

ATCAATCATTGTCCATAGAC′]

973
NM_006329.3(FBLN5): c.679T >
10516
FBLN5
[′GCAAACCTGCGTCAACACCTACGGCYCTTTC

C (p.Ser227Pro)

ATCTGCCGCTGTGACCCAGG′]

974
NM_006329.3(FBLN5): c.506T >
10516
FBLN5
[′TTGCTTGCATTTCTGTTTCCAGACAYTGATG

C (p.Ile169Thr)

AATGTCGCTATGGTTACTGC′]

975
NM_013339.3(ALG6): c.1432T >
29929
ALG6
[′GTTTTCTGTATTGGTGTGTTTTGTAYCTTGCT

C (p.Ser478Pro)

TGAACTTCCTGTTCTTCTT′]

976
NM_006899.3(IDH3B): c.395T >
3420
IDH3B
[′GAGCTAGCCTCCTATGATATGCGGCYGAGG

C (p.Leu132Pro)

TAGGTGGTCTGGGTGGGGTGA′]

977
NM_014363.5(SACS): c.5836T >
26278
SACS
[′AATGGATTATACTTACTATGCAGTAYGGCCC

C (p.Trp1946Arg)

GATCCTGATTTAGTTCATGA′]

978
NM_014363.5(SACS): c.9742T >
26278
SACS
[′AAGTGAGTCTTGGCTTAAGAATGCAYGGCA

C (p.Trp3248Arg)

TTTTATTAGTGAATCTGTAAG′]

979
NM_014363.5(SACS): c.3161T >
26278
SACS
[′CAGATGGTATCAGCTGGTGAACTCTYTGACC

C (p.Phe 1054Ser)

CTGATATAGAAGTACTAAAG′]

980
NM_014324.5(AMACR):
−1
—
[′GAGCCGCTTGGGCCGGGGCAAGCGCYCGCT

c.154T > C (p.Ser52Pro)

AGTGCTGGACCTGAAGCAGCC′]

981
NM_014324.5(AMACR):
−1
—
[′AATCCAAGGCTTATTTATGCCAGGCYGAGTG

c.320T > C (p.Leu107Pro)

GATTTGGCCAGTCAGGAAGC′]

982
NM_001040108.1(MLH3):
27030
MLH3
[′GACAGAGGAACAAAGGAGACTCTTAYGGTC

6c.382T > C (p.Trp1276Arg)

AGTACCACCATGAGAATGTGA′]

983
NM_014336.4(AIPL1): c.715T > C
23746
AIPL1
[′TACTCTGATCCTCAACTACTGCCAGYGCCTG

(p.Cys239Arg)

CTGAAGAAGGAGGAGTACTA′]

984
NM_001001486.1(ATP2C1):
27032
ATP2C1
[′CTCTCATTTGCTTTAGCCAGTCGTCYGGGAT

c.1751T > C (p.Leu584Pro)

TGTATTCCAAAACTTCCCAG′]

985
NM_007194.3(CHEK2): c.470T >
11200
CHEK2
[′GAAGTGGGTCCTAAAAACTCTTACAYTGCAT

C (p.Ile157Thr)

ACATAGAAGATCACAGTGGC′]

986
NM_007255.2(B4GALT7):
11285
B4GALT7
[′ACCTATGTCGGCGGCATCCTGCTGCYCTCCA

c.617T > C (p.Leu206Pro)

AGCAGCACTACCGGCTGGTG′]

987
NM_000030.2(AGXT): c.613T > C
189
AGXT
[′ATCTACAGGCATCGACATCCTGTACYCGGGC

(p.Ser205Pro)

TCCCAGAAGGCCCTGAACGC′]

988
NM_000030.2(AGXT): c.731T > C
189
AGXT
[′AAGCCCTTCTCCTTCTACCTGGACAYCAAGT

(p.Ile244Thr)

GGCTGGCCAACTTCTGGGGC′]

989
NM_201253.2(CRB1): c.3122T >
23418
CRB1
[′ACATGGCACGAAGTGACCCTTTCCAYGACA

C (p.Met1041Thr)

GACCCACTGTCCCAGACCTCC′]

990
NM_201253.2(CRB1): c.3541T >
23418
CRB1
[′ACACTGTGAACTCAACATCGATGAAYGCTTT

C (p.Cys1181Arg)

TCAAACCCCTGTATCCATGG′]

991
NM_005094.3(SLC27A4):
10999
SLC27A4
[′AGATAAACTGTTCTACATCTACACAYCCGGC

c.739T > C (p.Ser247Pro)

ACCACAGGGCTGCCCAAGGC′]

992
NM_032551.4(KISS1R): c.443T >
84634
KISS1R
[′CGCTGGTACGTGACGGTGTTCCCGTYGCGCG

C (p.Leu148Ser)

CCCTGCACCGCCGCACGCCC′]

993
NM_032551.4(KISS1R): c.305T >
84634
KISS1R
[′TGCTGCGTCCCCTTCACGGCCCTGCYGTACC

C (p.Leu102Pro)

CGCTGCCCGGCTGGGTGCTG′]

994
NM_014270.4(SLC7A9):
11136
SLC7A9
[′ATCTCCATCATCGTGGGCACCATCAYTGGCT

c.131T > C (p.Ile44Thr)

CTGGGATCTTCGTTTCCCCC′]

995
NM_003332.3(TYROBP): c.2T >
7305
TYROBP
[′TGGTGTCCAGCAGCATCCGGCTTCAYGGGG

C (p.Met1Thr)

GGACTTGAACCCTGCAGCAGG′]

996
NM_000843.3(GRM6): c.1214T >
−1
—
[′CAGGAGGGCAAGGTGCAGTTTGTGAYTGAT

C (p.Ile405Thr)

GCGGTGTACGCCATTGCCCAC′]

997
NM_022336.3(EDAR): c.259T > C
10913
EDAR
[′GTTTTCCAAAGGAGGCTACCAGATAYGCAG

(p.Cys87Arg)

GCGTCACAAAGACTGTGAGGG′]

998
NM_003835.3(RGS9): c.895T > C
8787
RGS9
[′CCCAACCAAGATGCGAGTGGAACGAYGGGC

(p.Trp299Arg)

CTTCAACTTCAGCGAATTGAT′]

999
NM_004870.3(MPDU1): c.356T >
9526
MPDU1
[′CTCCAGACGATCACCATCTGCTTCCYGGTCA

C (p.Leu119Pro)

TGCACTACAGAGGACAGACT′]

1000
NM_004870.3(MPDU1): c.2T > C
9526
MPDU1
[′ACTGGCGGAAGCTAGCTTTGCAATAYGGCG

(p.Met1Thr)

GCCGAGGCGGACGGACCGCTT′]

1001
NM_004870.3(MPDU1): c.221T >
9526
MPDU1
[′CTGGGAGCCAAGAGTGCTGAAGGGTYGAGT

C (p.Leu74Ser)

CTCCAGTCTGTAATGCTGGAG′]

1002
NM_000334.4(SCN4A):
6329
SCN4A
[′ACGCTGAACATGCTCATCAAGATCAYTGGC

c.2078T > C (p.Ile693Thr)

AATTCAGTGGGGGCGCTGGGT′]

1003
NM_006580.3(CLDN16):
10686
CLDN16
[′GCTGGGTTTGGATTTCTCACCCTGCYCCTTG

c.500T > C (p.Leu167Pro)

GTCTTGACTGCGTGAAATTC′]

1004
NM_006580.3(CLDN16):
10686
CLDN16
[′ATATGCCCTGGTCTTCCAGTGAAGCYGGTGG

c.434T > C (p.Leu145Pro)

TAACTCGAGCGTTGATGATT′]

1005
NM_003907.2(EIF2B5):
8893
EIF2B5
[′CTTTCTTCCATAGCTGCTAAAGGCCYGGAGC

c.1882T > C (p.Trp628Arg)

CCTGTTTTTAGGAACTACAT′]

1006
NM_183235.2(RAB27A):
5873
RAB27A
[′TATTGTGAAAACCCAGATATAGTGCYGTGTG

c.389T > C (p.Leu130Pro)

GAAACAAGAGTGATCTGGAG′]

1007
NM_001128227.2(GNE):
10020
GNE
[′CCCGCCCTGCTGGGTGCTGCCAGCAYGGTTC

c.2228T > C (p.Met743Thr)

TGGACTACACAACACGCAGG′]

1008
NM_004273.4(CHST3): c.776T >
9469
CHST3
[′CGCTGCGGCCCCCTCAACGTGACGCYGGCC

C (p.Leu259Pro)

GCAGAGGCCTGCCGCCGCAAG′]

1009
NM_004273.4(CHST3): c.920T >
9469
CHST3
[′CTGGTGCGCGACCCCCGGGCCGTGCYGGCC

C (p.Leu307Pro)

TCGCGCATGGTGGCCTTCGCC′]

1010
NM_004273.4(CHST3): c.857T >
9469
CHST3
[′CGGCAGCTGGAGTTCCTGCAGCCGCYGGCC

C (p.Leu286Pro)

GAGGACCCCCGCCTGGACCTG′]

1011
NM_172201.1(KCNE2): c.161T >
9992
KCNE2
[′TTCTACTATGTCATCCTGTACCTCAYGGTGA

C (p.Met54Thr)

TGATTGGAATGTTCTCTTTC′]

1012
NM_172201.1(KCNE2): c.170T >
9992
KCNE2
[′GTCATCCTGTACCTCATGGTGATGAYTGGAA

C (p.Ile57Thr)

TGTTCTCTTTCATCATCGTG′]

1013
NM_172201.1(KCNE2): c.178T >
9992
KCNE2
[′GTACCTCATGGTGATGATTGGAATGHTCTCT

C (p.Phe60Leu)

TTCATCATCGTGGCCATCCT′]

1014
NM_001139.2(ALOX12B)
242
ALOX12B
[′TCATCCTCCTTGCTCTCCCCACAGCYCCTCA

c.1277T > C (p.Leu426Pro)

TCCCCCATACCCGATACACC′]

1015
NM_003640.3(IKBKAP):
8518
IKBKAP
[′ATTCGGAAGTGGTTGGACAAGTAAGYGCCA

c.2204 + 6T > C

TTGTACTGTTTGCGACTAGTT′]

1016
NM_005413.3(SIX3): c.749T > C
6496
SIX3
[′GCCACCGGCCTCACTCCCACACAAGYAGGC

(p.Val250Ala)

AACTGGTTTAAGAACCGGCGG′]

1017
NM_004820.3(CYP7B1):
9420
CYP7B1
[′TTTATTAGTGAGCTAAGAGATGATTYTTTAA

c.647T > C (p.Phe216Ser)

AATTTGATGACAAGTTTGCA′]

1018
NM_194248.2(OTOF): c.3032T >
9381
OTOF
[′CTGTGTCCCACCTGGGACCAGATGCYGGTGT

C (p.Leu1011Pro)

TCGACAACCTGGAGCTCTAT′]

1019
NM_194248.2(OTOF): c.1544T >
9381
OTOF
[′GACGTGGCCATCGGCACCCACTTCAYTGACC

C (p.Ile515Thr)

TGCGCAAGATTTCTAATGAC′]

1020
NM_004737.4(LARGE):
9215
LARGE
[′GATGCTGGAGGCCATCTGCAAGCACYGGGA

c.1483T > C (p.Trp495Arg)

GGGGCCCATCAGCCTGGCCCT′]

1021
NM_002420.5(TRPM1): c.296T >
4308
TRPM1
[′GAGGCCTCCATGCACAGATATTAAGRGCTTG

C (p.Leu99Pro)

GGGAGTTCCAGCTGCCAATC′]

1022
NM_004700.3(KCNQ4): c.842T >
9132
KCNQ4
[′ACCTGTTTGTGTCTCCAGATTACATYGACAA

C (p.Leu281Ser)

CCATCGGCTATGGTGACAAG′]

1023
NM_003839.3(TNFRSF11A):
8792
TNFRSF11A
[′ACTGAACCACCTTTTCCCCCACAGCYGTACC

c.523T > C (p.Cys175Arg)

TTCCTTGGAAAGAGAGTAGA′]

1024
NM_030761.4(WNT4): c.35T > C
54361
WNT4
[′CGCTCGTGCCTGCGTTCGCTGCGCCYCCTCG

(p.Leul2Pro)

TCTTCGCCGTCTTCTCAGCC′]

1025
NM_000050.4(ASS1): c.535T > C
445
ASS1
[′CATCCCGGTCACTCCCAAGAACCCGYGGAG

(p.Trp179Arg)

CATGGATGAGAACCTCATGCA′]

1026
NM_002977.3(SCN9A):
−1
—
[′ACATTGAACATGCTGATTAAGATCAYTGGTA

c.2543T > C (p.Ile848Thr)

ACTCAGTAGGGGCTCTAGGT′]

1027
NM_002977.3(SCN9A):
−1
—
[′TTTCTTTACCTTGGAGGTCAAGACAYCTTTA

c.4382T > C (p.Ile1461Thr)

TGACAGAAGAACAGAAGAAA′]

1028
NM_002977.3(SCN9A): c.647T >
6335
SCN9A
[′GGCAATGTTTCAGCTCTTCGAACTTYCAGAG

C (p.Phe216Ser)

TATTGAGAGCTTTGAAAACT′]

1029
NM_003880.3(WISP3): c.232T >
8838
WISP3
[′AGATGGCTGTGGATGCTGTAAAATCYGTGC

C (p.Cys78Arg)

CAAGCAACCAGGGGAAATCTG′]

1030
NM_003880.3(WISP3): c.1000T >
8838
WISP3
[′TAAATGGAAGATGCTGTGGATTACAYCTTGT

C (p.Ser334Pro)

GTGTGTCAGAGAAACTGCAG′]

1031
NM_001457.3(FLNB): c.703T > C
2317
FLNB
[′CGAGCACTCAGTTATGACTTACCTGYCCCAG

(p.Ser235Pro)

TTCCCCAAAGCCAAGCTCAA′]

1032-
NM_003060.3(SLC22A5):
6584
SLC22A5
[′GATTTGTTACTGACAAGGCCTAGGGNAAGTT

1036
c.1051T > C (p.Trp351Arg)

TTCACAGCCTAAAACACAGT′,

′TACAAGACCTAAGTTCCAAGAAGCARCAGTC

CCACAACATTCTGGATCTGC′,

′GGTCACCATCATGTCCATAATGCTGYGGTAT

GTAAAAGAGACCTGCCTGAG′,

′ATGCCTCAGACAAAATTCAAAGCCTRTGTCA

TCAGAGAGTGAAAAGGATAT′,

′GGCTGTTGTGGGAAATATGGACTCTYGTGGG

GAATCTCTCCAGATCTTAAG′]

1037
NM_000369.2(TSHR): c. 1891T >
7253
TSHR
[′TGCCAAGAGGATGGCTGTGTTGATCYTCACC

C (p.Phe631Leu)

GACTTCATATGCATGGCCCC′]

1038
NM_000369.2(TSHR): c. 1358T >
7253
TSHR
[′AAACTGAACGTCCCCCGCTTTCTCAYGTGCA

C (p.Met453Thr)

ACCTGGCCTTTGCGGATTTC′]

1039
NM_000369.2(TSHR): c.1526T >
7253
TSHR
[′ACTGTCTTTGCAAGCGAGTTATCGGYGTATA

C (p.Val509Ala)

CGCTGACGGTCATCACCCTG′]

1040
NM_000369.2(TSHR): c. 1798T >
7253
TSHR
[′AGTTGCCTTCGTCATCGTCTGCTGCYGTTAT

C (p.Cys600Arg)

GTGAAGATCTACATCACAGT′]

1041
NM_000369.2(TSHR): c.1400T >
7253
TSHR
[′GCGGATTTCTGCATGGGGATGTACCYGCTCC

C (p.Leu467Pro)

TCATCGCCTCTGTAGACCTC′]

1042
NM_001003722.1(GLE1):
2733
GLE1
[′CAGAAATGTTTGCAACACAAGGACAYTCCT

c.2051T > C (p.Ile684Thr)

GTCCCCAAGGGCTTTCTGACT′]

1043
NM_024009.2(GJB3): c.101T > C
2707
GJB3
[′TCCGTGGTGTTCGTCTTCCGGGTGCYGGTAT

(p.Leu34Pro)

ACGTGGTGGCTGCAGAGCGC′]

1044
NM_001080463.1(DYNC2H1):
79659
DYNC2H1
[′GATTTGCTCAGAGTAGCTGATACAAYTGTAG

c.3719T > C (p.Ile1240Thr)

CCAAAGCTGCCGACCTTAAA′]

1045
NM_018129.3(PNPO): c.784T > C
55163
PNPO
[′CTGGCTCTATGAGAGACTTGCACCTYAACTC

(p.Ter262Gln)

TGGGACCTGCTGGCCCAGAG′]

1046
NM_003722.4(TP63): c.1033T > C
8626
TP63
[′CCGACGCTGCTTTGAGGCCCGGATCYGTGCT

(p.Cys345Arg)

TGCCCAGGAAGAGACAGGAA′]

1047
NM_003722.4(TP63): c.1646T > C
8626
TP63
[′CCTCCGTATCCCACAGATTGCAGCAYTGTCA

(p.Ile549Thr)

GGTGAGTCCACAGCATGTGC′]

1048
NM_003722.4(TP63): c.1738T > C
8626
TP63
[′CACCATCTATCAGATTGAGCATTACBCCATG

(p.Ser580Pro)

GATGTAAGTAACTGTTAGAC′]

1049
NM_004086.2(COCH): c.349T > C
−1
—
[′CATCCAGTCTCAAATGCTTTCTAGAYGGTCT

(p.Trp117Arg)

GCTTCTTTCACAGTAACTAG′]

1050
NM_004086.2(COCH): c.1535T >
−1
—
[′GCACCTCTGGATGACCTGAAAGATAYGGCT

C (p.Met512Thr)

TCTAAACCGAAGGAGTCTCAT′]

1051
NM_006412.3(AGPAT2):
10555
AGPAT2
[′ACAGGAACAGTCACAGTGCAGGTGCYGGAA

c.683T > C (p.Leu228Pro)

GCCATCCCCACCAGCGGCCTC′]

1052
NM_003659.3(AGPS): c.1406T >
8540
AGPS
[′AATCAGCTAAGTGTAGCCACATTACYGTTTG

C (p.Leu469Pro)

AGGGGGATCGTGAGAAGGTT′]

1053
NM_004550.4(NDUFS2):
4720
NDUFS2
[′GGGAGAGTTTGGGGTGTACCTGGTGYCTGA

c.1237T > C (p.Ser413Pro)

TGGCAGCAGCCGCCCTTATCG′]

1054
NM_006892.3(DNMT3B):
1789
DNMT3B
[′CCAGTGGTTTGGCGATGGCAAGTTCYCCGA

c.808T > C (p.Ser270Pro)

GGTGAGTCCGGGGAAGGGCAA′]

1055
NM_002538.3(OCLN): c.656T > C
100506658
OCLN
[′CAAATATATGCCCTCTGCAACCAATYTTATA

(p.Phe219Ser)

CACCTGCAGCTACTGGACTC′]

1056
NM_001211.5(BUB1B):
−1
—
[′AATGATGAGGCCACAGTGTCTGTTCYTGGG

c.3035T > C (p.Leu1012Pro)

GAGCTTGCAGCAGAAATGAAT′]

1057
NM_016203.3(PRKAG2):
51422
PRKAG2
[′ACAGAATCTTGCTGCTGAGAAAACAYACAA

c.1459T > C (p.Tyr487His)

TAACCTAGATATCACGGTGAC′]

1058
NM_016203.3(PRKAG2):
51422
PRKAG2
[′TAGTATTGTGGGTATTATTTCCCTGYCGGAC

c.1642T > C (p.Ser548Pro)

ATTCTGCAAGCCCTGATCCT′]

1059
NM_001287.5(CLCN7):
1186
CLCN7
[′TTCAAGCTGTTCCGGGCCCTGGGCCYGCGGC

c.2297T > C (p.Leu766Pro)

ACCTGGTGGTGGTGGACAAC′]

1060
NM_004646.3(NPHS1): c.793T >
4868
NPHS1
[′GGCAGGACAGAGCTTGGAGCTGCCGYGCGT

C (p.Cys265Arg)

GGCCCGAGGGGGTAATCCCTT′]

1061
NM_003002.3(SDHD): c.416T > C
6392
SDHD
[′CTTTCAGCTTTAACCTTTGCTGGGCYTTGCT

(p.Leu139Pro)

ATTTCAACTATCACGATGTG′]

1062
NM_001164277.1(SLC37A4):
2542
SLC37A4
[′TAATGGCCTGGCCCAGGGGCTGGGCYGGCC

c.352T > C (p.Trp118Arg)

CCCATGTGGGAAGGTCCTGCG′]

1063
NM_002546.3(TNFRSF11B):
4982
TNFRSF11B
[′GGAAGGGCGCTACCTTGAGATAGAGYTCTG

c.349T > C (p.Phe117Leu)

CTTGAAACATAGGAGCTGCCC′]

1064
NM_005422.2(TECTA):
7007
TECTA
[′GGGCGTGAGGATCAATGACAGACAGBGCAC

c.5509T> C (p.Cys1837Arg)

CGGCATCGAGGGGGAAGATTT′]

1065
NM_007262.4(PARK7): c.497T >
11315
PARK7
[′CCTGGGACCAGCTTCGAGTTTGCGCYTGCAA

C (p.Leu166Pro)

TTGTTGAAGCCCTGAATGGC′]

1066
NM_006009.3(TUBA1A):
7846
TUBA1A
[′GCTCGCCTGGACCACAAGTTTGACCYGATGT

c.1190T > C (p.Leu397Pro)

ATGCCAAACGTGCCTTTGTT′]

1067
NM_002700.2(POU4F3):
5459
POU4F3
[′CTCAAGATCCCCGGCGTGGGCTCGCYGAGC

c.668T > C (p.Leu223Pro)

CAAAGCACCATCTGCAGGTTC′]

1068
NM_005025.4(SERPINI1):
5274
SERPINI1
[′TGGTGAAGATGAAAATATTCTCTTCYCTCCA

c.145T > C (p.Ser49Pro)

TTGAGTATTGCTCTTGCAAT′]

1069
NM_001040667.2(HSF4):
3299
HSF4
[′TTCGTGCGCGGCCGCGAGCAGCTACYGGAG

c.341T > C (p.Leu114Pro)

CGCGTGCGGCGCAAGGTGGGG′]

1070
NM_002942.4(ROBO2):
6092
ROBO2
[′AATAGCAACAGTGGCCCAAATGAGAYTGGA

c.2834T > C (p.Ile945Thr)

AATTTTGGCCGTGGAGGTAAG′]

1071
NM_000492.3(CFTR): c.3857T >
1080
CFTR
[′ACTTTGCAACAGTGGAGGAAAGCCTYTGGA

C (p.Phe1286Ser)

GTGATACCACAGGTGAGCAAA′]

1072
NM_000492.3(CFTR): c.3763T >
1080
CFTR
[′TGGATCAGGGAAGAGTACTTTGTTAYCAGCT

C (p.Ser1255Pro)

TTTTTGAGACTACTGAACAC′]

1073
NM_000492.3(CFTR): c.3194T >
1080
CFTR
[′ACAAGCTTAAAAGGACTATGGACACBTCGT

C (p.Leu1065Pro)

GCCTTCGGACGGCAGCCTTAC′]

1074
NM_000492.3(CFTR):
1080
CFTR
[′TGTCTGCCATTCTTAAAAACAAAAAYGTTGT

c.3469 − 20T > C

TATTTTTATTTCAGATGCGA′]

1075
NM_005603.4(ATP8B1):
5205
ATP8B1
[′TTTTGGAGAAACACAAGTTTTCCTTYGGATG

c.863T > C (p.Leu288Ser)

CTGATAAAATTTTGTTACGT′]

1076
NM_005603.4(ATP8B1):
5205
ATP8B1
[′GAGGAGATTGAAAAAGACTTAATTGYGAGT

c.2097 + 2T > C

TTTAGCCTTAATAACTTTTTC′]

1077
NM_005603.4(ATP8B1):
5205
ATP8B1
[′ACCCTATGCCTTTGCTACAAGGAAAYTGAA

c.1982T > C (p.Ile661Thr)

GAAAAAGAATTTACAGAATGG′]

1078
NM_005144.4(HR):
55806
HR
[′CGCAGCACGGAGTCTCGGCGTCCCAYGGCG

c.−320T > C

CAACCTACGGCCTCGGCCCAG′]

1079
NM_003322.4(TULP1):
7287
TULP1
[′GGTCACCCAGGCCTCAGTCAAGAACYTCCA

c.1471T > C (p.Phe491Leu)

GATTGTCCACGCTGATGACCG′]

1080
NM_003322.4(TULP1):
7287
TULP1
[′CTCCTGGGGAACCGCTTCACGGTCTYTGACA

c.1145T > C (p.Phe382Ser)

ACGGGCAGAACCCACAGCGT′]

1081
NM_000455.4(STK11): c.200T >
6794
STK11
[′TCTTACGGCAAGGTGAAGGAGGTGCYGGAC

C (p.Leu67Pro)

TCGGAGACGCTGTGCAGGAGG′]

1082
NM_002241.4(KCNJ10):
3766
KCNJ10
[′TGGCTTCCGCTACATCAGTGAGGAAYGTCCA

c.418T > C (p.Cys140Arg)

CTGGCCATTGTGCTTCTTAT′]

1083
NM_001172567.1(MYD88):
4615
MYD88
[′TCTGTAGGCCGACTGCTCGAGCTGCYTACCA

c.317T > C (p.Leu106Pro)

AGCTGGGCCGCGACGACGTG′]

1084
NM_000466.2(PEX1): c.1991T >
5189
PEX1
[′CCATCTGTTGTCCTGCTGGATGACCYTGACC

C (p.Leu664Pro)

TCATTGCTGGACTGCCTGCT′]

1085
NM_001303.3(COX10): c.2T > C
1352
COX10
[′GGAGCGGCCCCAGACTCGTAAATTAYGGCC

(p.Met1Thr)

GCATCTCCGCACACTCTCTCC′]

1086
NM_001300.5(KLF6): c.346T > C
1316
KLF6
[′TGTCAGCAGCGAATCCTCTGACAGCYCCGA

(p.Ser116Pro)

GGAACTTTCTCCCACGGCCAA′]

1087
NM_001300.5(KLF6): c.190T > C
1316
KLF6
[′CAAATTTGACAGCCAGGAAGATCTGYGGAC

(p.Trp64Arg)

CAAAATCATTCTGGCTCGGGA′]

1088
NM_001300.5(KLF6): c.506T > C
1316
KLF6
[′CTGTGGGGTTGCGTGCCCGGGGAGCYGCCC

(p.Leu169Pro)

TCGCCAGGGAAGGTGCGCAGC′]

1089
NM_000085.4(CLCNKB):
1188
CLCNKB
[′CGGGTACTTCATGCCCATCTTTGTCYATGGT

c.1294T > C (p.Tyr432His)

GAGTCTGGGGTCCTGAGGTT′]

1090
NM_000214.2(JAG1): c.110T > C
182
JAG1
[′TGTGGGGCCTCGGGTCAGTTCGAGTYGGAG

(p.Leu37Ser)

ATCCTGTCCATGCAGAACGTG′]

1091
NM_003865.2(HESX1): c.77T > C
8820
HESX1
[′ACTTGCTCCTTTTCAATTGAGAGAAYCTTAG

(p.Ile26Thr)

GACTGGACCAGAAGAAAGAC′]

1092
NM_003865.2(HESX1):
8820
HESX1
[′TCATTATTGGGTGAAAAAACTTCCCDCCTGG

c.357 + 2T > C

TTTTGAGTAAAAGCAGTTCT′]

1093
NM_002618.3(PEX13): c.977T >
5194
PEX13
[′CTTGATGGCCAAACAACAGGACTTAYACCT

C (p.Ile326Thr)

GCGAATTATGTCAAAATTCTT′]

1094
NM_000303.2(PMM2): c.395T >
5373
PMM2
[′AATGGGATGTTAAACGTGTCCCCTAYTGGA

C (p.Ile132Thr)

AGAAGCTGCAGCCAAGAAGAA′]

1095
NM_000303.2(PMM2): c.131T >
5373
PMM2
[′AGGCAGAAGATCAAAATCGGAGTGGYAGGC

C (p.Val44Ala)

GGATCGGACTTTGAGAAAGTG′]

1096
NM_000104.3(CYP1B1): c.2T > C
1545
CYP1B1
[′CGCCTTCTCCTCTCTGTCCCCAGCAYGGGCA

(p.Met1Thr)

CCAGCCTCAGCCCGAACGAC′]

1097
NM_032977.3(CASP10):
843
CASP10
[′AAAGACTCGCTTCCCAAAACTGAAAYGGTG

c.440T > C (p.Met147Thr)

AGTGGGTCATACAGAATGGGT′]

1098
NM_003999.2(OSMR): c.2072T >
9180
OSMR
[′GGTTCAGAATGTTGCAAATACAAAAYTGAC

C (p.Ile691Thr)

AACCCGGAAGAAAAGGCATTG′]

1099
NM_000314.6(PTEN): c.370T > C
5728
PTEN
[′TGACAATCATGTTGCAGCAATTCACBGTAAA

(p.Cys124Arg)

GCTGGAAAGGGACGAACTGG′]

1100
NM_000314.6(PTEN): c.209T > C
5728
PTEN
[′AAAAACCATTACAAGATATACAATCYGTAA

(p.Leu70Pro)

GTATGTTTTCTTATTTGTATG′]

1101
NM_000314.6(PTEN): c.335T > C
5728
PTEN
[′TTTTGTGAAGATCTTGACCAATGGCYAAGTG

(p.Leu112Pro)

AAGATGACAATCATGTTGCA′]

1102
NM_000314.6(PTEN): c.722T > C
5728
PTEN
[′CGACGGGAAGACAAGTTCATGTACTYTGAG

(p.Phe241Ser)

TTCCCTCAGCCGTTACCTGTG′]

1103
NM_006949.3(STXBP2):
6813
STXBP2
[′TTGGCCCACGCCGTCCTGGCCAAGCHGAAC

c.626T > C (p.Leu209Pro)

GCCTTCAAGGCAGACACTCCC′]

1104
NM_000358.2(TGFBI): c.1619T >
7045
TGFBI
[′AACCGGGAAGGAGTCTACACAGTCTYTGCT

C (p.Phe540Ser)

CCCACAAATGAAGCCTTCCGA′]

1105
NM_000350.2(ABCA4):
24
ABCA4
[′CAGCTCACCCAACGTGCCCTCTCTCYACTGG

c.1622T > C (p.Leu541Pro)

AGGAAAACATGTTCTGGGCC′]

1106
NM_000350.2(ABCA4):
24
ABCA4
[′GGAAATAAAACTGACATCTTAAGGCYACAT

c.5819T > C (p.Leu1940Pro)

GAACTAACCAAGGTAAGGGAA′]

1107
NM_000860.5(HPGD): c.577T > C
3248
HPGD
[′CTTTGTTAACACAGCCATCCTTGAAYCAATT

(p.Ser193Pro)

GAAAAAGAAGAAAACATGGG′]

1108
NM_000223.3(KRT12): c.386T >
3859
KRT12
[′CTTTCTGGATCAGAAAAAGAAACTAYGCAA

C (p.Met129Thr)

AATCTTAATGATAGATTAGCT′]

1109
NM_000503.5(EYA1): c. 1459T >
2138
EYA1
[′GTTGACACTGGCCCTGAAAGCACTCYCGCTC

C (p.Ser487Pro)

ATTCACTCCCGGTGAGGCTC′]

1110
NM_000261.1(MYOC):
4653
MYOC
[′TGCCTTCATCATCTGTGGCACCTTGYACACC

c.1309T > C (p.Tyr437His)

GTCAGCAGCTACACCTCAGC′]

1111
NM_000261.1(MYOC):
4653
MYOC
[′GTCAGTCGCCAATGCCTTCATCATCYGTGGC

c.1297T > C (p.Cys433Arg)

ACCTTGTACACCGTCAGCAG′]

1112
NM_130838.1(UBE3A): c.389T >
7337
UBE3A
[′GATTATTCCCCTTTAATCCGTGTTAYTGGAA

C (p.Ile130Thr)

GAGTTTTTTCTAGTGCTGAG′]

1113
NM_000474.3(TWIST1):
7291
TWIST1
[′TCGCTGAACGAGGCGTTCGCCGCGCYGCGG

c.392T > C (p.Leu131Pro)

AAGATCATCCCCACGCTGCCC′]

1114
NM_000192.3(TBX5): c.161T > C
6910
TBX5
[′TCCTTCTTGCAGGGCATGGAGGGAAYCAAA

(p.Ile54Thr)

GTGTTTCTCCATGAAAGAGAA′]

1115
NM_002905.3(RDH5): c.841T > C
−1
—
[′GACTGCTCGACACCCCCGAACCCGCBACAG

(p.Tyr281His)

CCCAGGTTGGGATGCCAAGCT′]

1116
NM_001089.2(ABCA3): c.302T >
21
ABCA3
[′GTCACTGAGACAGTGCGCAGGGCACYTGTG

C (p.Leu101Pro)

ATCAACATGCGAGGTGAGACA′]

1117
NM_001089.2(ABCA3):
21
ABCA3
[′ATGGACCCCGTGGCCCGGCGCCTGCYTTGG

c.4658T > C (p.Leu1553Pro)

GACACCGTGGCACGAGCCCGA′]

1118
NM_001089.2(ABCA3): c.977T >
21
ABCA3
[′ATCGCCGCCTCCTTCATGACCCTGCYCTTCT

C (p.Leu326Pro)

GTGTCAAGGTGAGCATGGCG′]

1119
NM_005535.2(IL12RB1):
3594
IL12RB1
[′CTGCCTCTCCCCAGAGTCCTGCCTCYGCCCC

c.592T > C (p.Cys198Arg)

CTGGAGATGAATGTGGCCCA′]

1120
NM_005055.4(RAPSN): c.41T > C
5913
RAPSN
[′ACCAAGCAGCAGATCGAGAAGGGGCYCCAG

(p.Leu14Pro)

CTGTACCAGTCCAACCAGACA′]

1121
NM_005055.4(RAPSN): c.848T >
5913
RAPSN
[′ATCATGACCGAGATCGGAAACCGCCYGGGG

C (p.Leu283Pro)

CAGGTGCAGGCGCTGCTGGGT′]

1122
NM_005055.4(RAPSN): c.416T >
5913
RAPSN
[′AATGCCTTCCTGGGCCTCAGCGTCTYCCAGA

C (p.Phe139Ser)

AGGCCCTGGAGAGCTTCGAG′]

1123
NM_005570.3(LMAN1): c.2T > C
3998
LMAN1
[′CTCCTCCGCGTTCCAGAATCCAAGAYGGCG

(p.Met1Thr)

GGATCCAGGCAAAGGGGTCTC′]

1124
NM_000430.3(PAFAH1B1):
5048
PAFAH1B1
[′CAGCGGCAAGCTTCTGGCTTCCTGTYCTGCA

5c.50T > C (p.Ser169Pro)

GATATGACCATTAAACTATG′]

1125
NM_000430.3(PAFAH1B1):
5048
PAFAH1B1
[′GGCTATGAAGAGGCATATTCAGTTTYTAAA

c.92T > C (p.Phe31Ser)

AAGGAAGCTGAATTAGATGTG′]

1126
NM_006261.4(PROP1): c.263T >
5626
PROP1
[′CAGTTGGAACAGCTGGAGTCAGCCTYTGGG

C (p.Phe88Ser)

AGGAACCAGTACCCCGACATC′]

1127
NM_175929.2(FGF14): c.449T >
2259
FGF14
[′GAACTTTTTACCCCTGAATGCAAGTYTAAAG

C (p.Phe150Ser)

AATCTGTTTTTGAAAATTAT′]

1128
NM_004970.2(IGFALS):
3483
IGFALS
[′GTGGCTGGAGGGTAACCCCTGGGACYGTGG

c.1618T > C (p.Cys540Arg)

CTGCCCTCTCAAGGCGCTGCG′]

1129
NM_005379.3(MYO1A):
4640
MYO1A
[′CCCTTGCCTGTTCCGTCCCTAGACTYCTTCTC

c.2728T > C (p.Ser910Pro)

GGATTCTCCTCCTGACCAA′]

1130
NM_006302.2(MOGS): c.1954T >
7841
MOGS
[′GCACTGGGCCCCAGAGCTAGGAGTCYTTGC

C (p.Phe652Leu)

AGACTTTGGGAACCACACAAA′]

1131
NM_001009944.2(PKD1):
5310
PKD1
[′TACGTGCCCACCAACGGCTCAGCCTYGGTGC

c.2534T > C (p.Leu845Ser)

TCCAGGTGGACTCTGGTGCC′]

1132
NM_004329.2(BMPR1A):
657
BMPR1A
[′AGCCCAGCTACGCCGGACAATAGAAYGTTG

c.370T > C (p.Cys124Arg)

TCGGACCAATTTATGTAACCA′]

1133
NM_004329.2(BMPR1A):
657
BMPR1A
[′CCGAGTGATCCGTCATACGAAGATAYGCGT

c.1409T > C (p.Met470Thr)

GAGGTTGTGTGTGTCAAACGT′]

1134
NM_000452.2(SLC10A2):
6555
SLC10A2
[′GTGGCGGGTTACTCCCTGGGGTTTCYTCTGG

c.728T > C (p.Leu243Pro)

CTAGAATTGCTGGTCTACCC′]

1135
NM_030662.3(MAP2K2):
5605
MAP2K2
[′CAACTCGCCGTACATCGTGGGCTTCYACGGG

c.400T > C (p.Tyr134His)

GCCTTCTACAGTGACGGGGA′]

1136
NM_033337.2(CAV3): c.260T > C
859
CAV3
[′CTGCTGGGCGTCCCACTGGCCCTGCHCTGGG

(p.Leu87Pro)

GCTTCCTGTTCGCCTGCATC′]

1137
NM_000388.3(CASR): c.2417T >
846
CASR
[′CCGGAGAACTTCAATGAAGCCAAGTHCATC

C (p.Phe806Ser)

ACCTTCAGCATGCTCATCTTC′]

1138
NM_000388.3(CASR): c.382T > C
846
CASR
[′AATTGATTCTTTGAACCTTGATGAGYTCTGC

(p.Phe128Leu)

AACTGCTCAGAGCACATTCC′]

1139
NM_000388.3(CASR): c.1835T >
846
CASR
[′GAGTTTCTGTCGTGGACGGAGCCCTYTGGGA

C (p.Phe612Ser)

TCGCACTCACCCTCTTTGCC′]

1140
NM_000388.3(CASR): c.2641T >
846
CASR
[′GCGTTGCAGCACCGCAGCTCACGCTYTCAA

C (p.Phe881Leu)

GGTGGCTGCCCGGGCCACGCT′]

1141
NM_000388.3(CASR): c.374T > C
846
CASR
[′CAAAACAAAATTGATTCTTTGAACCYTGATG

(p.Leul25Pro)

AGTTCTGCAACTGCTCAGAG′]

1142
NM_000388.3(CASR): c.2362T >
846
CASR
[′CACCTGCCTGCTGGCTGCCATCTGCYTCTTC

C (p.Phe788Leu)

TTTGCCTTCAAGTCCCGGAA′]

1143
NM_000388.3(CASR): c.38T > C
846
CASR
[′AGCTGCTGCTGGGTCCTCTTGGCACYCACCT

(p.Leu13Pro)

GGCACACCTCTGCCTACGGG′]

1144
NM_030653.3(DDX11):
1663
DDX11
[′CTGGCATATTCCAGGTGCATCCAGGYGCGG

c.2271 + 2T > C

GCGTCATGCTGGGCTTGGGTC′]

1145
NM_001001557.2(GDF6):
392255
GDF6
[′TTCACCAGATCCCAGCGCAAGAACCYGTTC

c.866T > C (p.Leu289Pro)

GCAGAGATGCGCGAGCAGCTG′]

1146
NM_000557.4(GDF5): c.1322T >
−1
—
[′TGCGAGTTCCCATTGCGCTCCCACCYGGAGC

C (p.Leu441Pro)

CCACGAATCATGCAGTCATC′]

1147
NM_000392.4(ABCC2):
1244
ABCC2
[′TGATTCGGAAGCCACAGTCCGAGAGYGAGT

c.1967 + 2T > C

TGCCTTCTTTCCATCCTAATG′]

1148
NM_000396.3(CTSK): c.926T > C
1513
CTSK
[′AACTGGGGAAACAAAGGATATATCCYCATG

(p.Leu309Pro)

GCTCGAAATAAGAACAACGCC′]

1149
NM_000304.3(PMP22): c.47T > C
5376
PMP22
[′ATCATCGTCCTCCACGTCGCGGTGCYGGTGC

(p.Leul6Pro)

TGCTGTTCGTCTCCACGATC′]

1150
NM_000304.3(PMP22): c.82T > C
5376
PMP22
[′ATATCTATCTGATTCTCTCTAGCAAYGGATC

(p.Trp28Arg)

GTGGGCAATGGACACGCAAC′]

1151
NM_001453.2(FOXC1): c.335T >
2296
FOXC1
[′ATCTACCAGTTCATCATGGACCGCTHCCCCT

C (p.Phe112Ser)

TCTACCGGGACAACAAGCAG′]

1152
NM_001451.2(FOXF1):
2294
FOXF1
[′CCAAGACATCAAGCCTTGCGTGATGYGAGG

c.1138T > C (p.Ter380Arg)

CTGCCGCCGCAGGCCCTCCTG′]

1153
NM_006432.3(NPC2): c.199T > C
10577
NPC2
[′CTCTTTTTTTCTCTTAGATATTCAGYCTAAAA

(p.Ser67Pro)

GCAGCAAGGCCGTGGTGCA′]

1154
NM_001127221.1(CACNA1A):
773
CACNA1A
[′CTGAATGTGTTCTTGGCCATCGCTGYGGACA

c.2141T > C (p.Val714Ala)

ATCTGGCCAACGCCCAGGAG′]

1155
NM_001127221.1(CACNA1A):
773
CACNA1A
[′GGGTACCGCATGGAGATGTCCATTTYCTACG

c.4469T > C (p.Phe1490Ser)

TCGTCTACTTTGTGGTGTTC′]

1156
NM_001127221.1(CACNA1A):
773
CACNA1A
[′ATGCTCTTCTTCATCTATGCCATCAYTGGGA

c.5126T > C (p.Ile1709Thr)

TGCAGGTGAGTGTCGTGTCC′]

1157
NM_000901.4(NR3C2):
4306
NR3C2
[′CAGAGCTGGCAGAGGTTCTACCAACYGACC

c.2771T > C (p.Leu924Pro)

AAGCTGCTGGACTCCATGCAT′]

1158
NM_000901.4(NR3C2):
4306
NR3C2
[′GTGGAGTCGGGGAACGCCAAGCCGCYCTAC

c.2936T > C (p.Leu979Pro)

TTCCACCGGAAGTGACTGCCC′]

1159
NM_000339.2(SLC12A3):
6559
SLC12A3
[′CTCACCCTCCTCATTCCCTATCTCCYTGGCC

c.2576T > C (p.Leu859Pro)

GCAAGAGGAGGTGGAGCAAA′]

1160
NM_000339.2(SLC12A3):
6559
SLC12A3
[′CTGGGGTGCCTGCGAGGGGCTGGCCYGCAG

c.1261T > C (p.Cys421Arg)

CTATGGCTGGAACTTCACCGA′]

1161
NM_000339.2(SLC12A3):
6559
SLC12A3
[′TCGGTACAGGCTGGCTCCTACAACCYGGCCC

c.1868T > C (p.Leu623Pro)

TCAGCTACTCGGTGGGCCTC′]

1162
NM_000163.4(GHR): c.341T > C
2690
GHR
[′TCTGCTGGGGAAAACAGCTGTTACTYTAATT

(p.Phe114Ser)

CATCGTTTACCTCCATCTGG′]

1163
NM_000163.4(GHR): c.512T > C
2690
GHR
[′AGTTTAACTGGGATTCATGCAGATAYCCAA

(p.Ile171Thr)

GTGAGATGGGAAGCACCACGC′]

1164
NM_000525.3(KCNJ11):
3767
KCNJ11
[′ACTGAGGAGTGCCCACTGGCCATCCYGATC

c.440T > C (p.Leu147Pro)

CTCATCGTGCAGAACATCGTG′]

1165
NM_000525.3(KCNJ11):
3767
KCNJ11
[′CCGCTTTGTGTCCAAGAAAGGCAACYGCAA

c.124T > C (p.Cys42Arg)

CGTGGCCCACAAGAACATCCG′]

1166
NM_001122764.1(PPOX):
5498
PPOX
[′ACCGTGGTCGTGCTGGGCGGAGGCAYCAGC

c.35T > C (p.Ile12Thr)

GGCTTGGCCGCCAGTTACCAC′]

1167
NM_000182.4(HADHA):
3030
HADHA
[′AAAGAATCAAAGGCCTTGATGGGACYCTAC

c.1025T > C (p.Leu342Pro)

CATGGTCAGGTCCTGTGCAAG′]

1168
NM_003476.4(CSRP3): c.131T >
8048
CSRP3
[′CTGGCAGTGGCCTGCAGGAAGGCTCYTGAC

C (p.Leu44Pro)

AGCACGACAGTCGCGGCTCAT′]

1169
NM_001204.6(BMPR2): c.367T >
659
BMPR2
[′TTTCTGCTGTTGTAGCACAGATTTAHGTAAT

C (p.Cys123Arg)

GTCAACTTTACTGAGAATTT′]

1170
NM_000336.2(SCNN1B):
6338
SCNN1B
[′CATCCCAGGCACCCCGCCCCCCAACYATGA

c.1858T > C (p.Tyr620His)

CTCCCTGCGTCTGCAGCCGCT′]

1171
NM_002181.3(IHH): c.569T > C
3549
IHH
[′TCAAAGGCCCACGTGCATTGCTCCGYCAAGT

(p.Val190Ala)

CCGGTGAGCCGCCGCCGGGG′]

1172
NM_000193.3(SHH): c.349T > C
6469
SHH
[′TTTGGCCATCTCGGTGATGAACCAGBGGCCA

(p.Trp117Arg)

GGAGTGAAACTGCGGGTGAC′]

1173
NM_000193.3(SHH): c.995T > C
6469
SHH
[′GACCGCCGGCTCCTGCCCGCCGCTGYGCAC

(p.Val332Ala)

AGCGTGACCCTAAGCGAGGAG′]

1174
NM_000179.2(MSH6): c.2633T >
2956
MSH6
[′AAAATTATAGGGATCATGGAAGAAGBTGCT

C (p.Val878Ala)

GATGGTTTTAAGTCTAAAATC′]

1175
NM_000098.2(CPT2): c.1342T >
1376
CPT2
[′AACCCTCACTATTGACTGCGTCCAGYTTCAG

C (p.Phe448Leu)

AGAGGAGGCAAAGAATTCCT′]

1176
NM_007315.3(STAT1):
6772
STAT1
[′GGAACTGGATATATCAAGACTGAGTYGATT

c.2117T > C (p.Leu706Ser)

TCTGTGTCTGAAGTGTAAGTG′]

1177
NM_007315.3(STAT1):
6772
STAT1
[′AAGGACCAGCAGCCGGGGACCTTCCYGCTG

c.1799T > C (p.Leu600Pro)

CGGTTCAGTGAGAGCTCCCGG′]

1178
NM_024420.2(PLA2G4A):
5321
PLA2G4A
[′AGGGACAGCAACATTTACTGTATCTYCTATG

c.331T > C (p.Ser111Pro)

AAGGTGGGAGAAAAGAAAGA′]

1179
NM_000352.4(ABCC8): c.394T >
6833
ABCC8
[′CTATCACAACATCGAGACTTCCAACBTCCCC

C (p.Phe132Leu)

AAGCTGCTAATTGGTAGGTG′]

1180
NM_033163.3(FGF8): c.118T > C
2253
FGF8
[′GCTGGGCAGGGAGCTCGCTTCCCTGYTCCGG

(p.Phe40Leu)

GCTGGCCGGGAGCCCCAGGG′]

1181
NM_153767.3(KCNJ1):
3758
KCNJ1
[′AACATCTTTCTCATTATAAAGGCACRTGGCA

c.1013T > C (p.Met338Thr)

CAGTGAGGGGTCTCCACTTC′]

1182
NM_000095.2(COMP):
1311
COMP
[′AACCCACCCTGTCATCCAGGACAACYGCCC

c.982T > C (p.Cys328Arg)

GCTGGTGCGGAACCCAGACCA′]

1183
NM_000095.2(COMP): c.1042T >
1311
COMP
[′GGACGAGGACAAGTGGGGCGATGCGYGCGA

C (p.Cys348Arg)

CAACTGCCGGTCCCAGAAGAA′]

1184
NM_002047.2(GARS): c.548T > C
2617
GARS
[′ATCCTGGAGATCGATTGCACCATGCYCACCC

(p.Leu183Pro)

CTGAGCCAGTTTTAAAGTGA′]

1185
NM_000435.2(NOTCH3):
4854
NOTCH3
[′CCTCGACCGCATAGGCCAGTTCACCYGTATC

c.1363T > C (p.Cys455Arg)

TGTATGGCAGGTGGGTGGTG′]

1186
NM_001166107.1(HMGCS2):
3158
HMGCS2
[′CTGCTACGGTGGTACTGCCTCCCTCYTCAAT

c.520T > C (p.Phe174Leu)

GCTGCCAACTGGATGGAGTC′]

1187
NM_001038.5(SCNN1A):
6337
SCNN1A
[′CCAGCTCTCTGCTGGTTACTCACGAYGGCCC

c.1477T > C (p.Trp493Arg)

TCGGTGACATCCCAGGTAGA′]

1188
NM_000161.2(GCH1): c.662T > C
2643
GCH1
[′ATGGTAATGCGAGGTGTACAGAAAAYGAAC

(p.Met221Thr)

AGCAAAACTGTGACCAGCACA′]

1189
NM_000059.3(BRCA2):
675
BRCA2
[′CGCGTCTTTCCACAGCCAGGCAGTCYGTATC

c.7529T > C (p.Leu2510Pro)

TTGCAAAAACATCCACTCTG′]

1190
NM_000180.3(GUCY2D):
3000
GUCY2D
[′GGAGACAGGGTTTGGCTGAAGAAATYCCCA

c.1694T > C (p.Phe565Ser)

GGGGATCAGCACATAGCTATC′]

1191
NM_000180.3(GUCY2D):
3000
GUCY2D
[′AATGGGCAGCGACACGCGGCAGAGAYCGCC

c.2846T > C (p.Ile949Thr)

AACATGTCACTGGACATCCTC′]

1192
NM_198056.2(SCN5A):
6331
SCN5A
[′CTGTCACGATTTGAGGGCATGAGGGYAAGA

c.3963 + 2T > C

GAGGTGGCTGCCTTCCCACCA′]

1193
NM_000335.4(SCN5A):
6331
SCN5A
[′GAGTGAGGACGACTTCGATATGTTCYATGA

c.5380T > C (p.Tyr1794His)

GATCTGGGAGAAATTTGACCC′]

1194
NM_000023.2(SGCA): c.524T > C
6442
SGCA
[′CCCGGAGAGCTTCAGCTGCTCAACGYCACCT

(p.Val175Ala)

CTGCCTTGGACCGTGGGGGC′]

1195
NM_002427.3(MMP13): c.224T >
4322
MMP13
[′AGGCTCCGAGAAATGCAGTCTTTCTYCGGCT

C (p.Phe75Ser)

TAGAGGTGACTGGCAAACTT′]

1196
NM_002427.3(MMP13): c.221T >
4322
MMP13
[′GAGAGGCTCCGAGAAATGCAGTCTTYCTTC

C (p.Phe74Ser)

GGCTTAGAGGTGACTGGCAAA′]

1197
NM_002427.3(MMP13): c.272T >
4322
MMP13
[′CTTGACGATAACACCTTAGATGTCAYGAAA

C (p.Met91Thr)

AAGCCAAGATGCGGGGTTCCT′]

1198
NM_004525.2(LRP2): c.7564T >
4036
LRP2
[′CTCCTTTTGTATGACTAGGTACCTGYACTGG

C (p.Tyr2522His)

GCTGACTGGGATACACATGC′]

1199
NM_000211.4(ITGB2): c.446T >
3689
ITGB2
[′GATGACCTCAGGAATGTCAAGAAGCYAGGT

C (p.Leu149Pro)

GGCGACCTGCTCCGGGCCCTC′]

1200
NM_000211.4(ITGB2): c.412T >
3689
ITGB2
[′GTACTATCTGATGGACCTCTCCTACYCCATG

C (p.Ser138Pro)

CTTGATGACCTCAGGAATGT′]

1201
NM_005502.3(ABCA1):
19
ABCA1
[′CAAAATCAAGAAGATGCTGCCTGTGYGTCC

c.4429T > C (p.Cys1477Arg)

CCCAGGGGCAGGGGGGCTGCC′]

1202
NM_005502.3(ABCA1):
19
ABCA1
[′TTGACTGGGAGAGAACACGTGGAGTYCTTT

c.6026T > C (p.Phe2009Ser)

GCCCTTTTGAGAGGAGTCCCA′]

1203
NM_130439.3(MXI1):
4601
MXI1
[′AACAAAGCCAAAGCACACATCAAGGYGAGA

c.552 + 2T> C

ATTTTTACTTTCAGATTTGCA′]

1204
m.5874T > C
4579
MT-TY
[′GTCTTTAGATTTACAGTCCAATGCTYCACTC

AGCCATTTTACCTCACCCCC′]

1205
m.7512T > C
4574
MT-TS1
[′CCAACCCCATGGCCTCCATGACTTTYTCAAA

AAGGTATTAGAAAAACCATT′]

1206
m.7510T > C
4574
MT-TS1
[′AGCCAACCCCATGGCCTCCATGACTYTTTCA

AAAAGGTATTAGAAAAACCA′]

1207
m.7511T > C
4574
MT-TS1
[′GCCAACCCCATGGCCTCCATGACTTYTTCAA

AAAGGTATTAGAAAAACCAT′]

1208
m.616T > C
4558
MT-TF
[′CCTCCTCAAAGCAATACACTGAAAABGTTTA

GACGGGCTCACATCACCCCA′]

1209
m.4409T > C
4569
MT-TM
[′TATCACACCCCATCCTAAAGTAAGGYCAGCT

AAATAAGCTATCGGGCCCAT′]

1210
m.8356T > C
4566
MT-TK
[′AAAGATTAAGAGAACCAACACCTCTYTACA

GTGAAATGCCCCAACTAAATA′]

1211
m.12297T > C
4568
MT-TL2
[′AAAGGATAACAGCTATCCATTGGTCYTAGG

CCCCAAAAATTTTGGTGCAAC′]

1212
m.3271T > C
4567
MT-TL1
[′CCGGTAATCGCATAAAACTTAAAACYTTAC

AGTCAGAGGTTCAATTCCTCT′]

1213
m.3250T > C
4567
MT-TL1
[′GGTTTGTTAAGATGGCAGAGCCCGGYAATC

GCATAAAACTTAAAACTTTAC′]

1214
m.3290T > C
4567
MT-TL1
[′TAAAACTTTACAGTCAGAGGTTCAAYTCCTC

TTCTTAACAACATACCCATG′]

1215
m.4290T > C
4565
MT-TI
[′AAATATGTCTGATAAAAGAGTTACTYTGATA

GAGTAAATAATAGGAGCTTA′]

1216
m.4291T > C
4565
MT-TI
[′AATATGTCTGATAAAAGAGTTACTTYGATAG

AGTAAATAATAGGAGCTTAA′]

1217
m.9997T > C
4563
MT-TG
[′ATCTATTGATGAGGGTCTTACTCTTYTAGTA

TAAATAGTACCGTTAACTTC′]

1218
m.10010T > C
4563
MT-TG
[′GGTCTTACTCTTTTAGTATAAATAGYACCGT

TAACTTCCAATTAACTAGTT′]

1219
m.4336T > C
4572
MT-TQ
[′GCTTAAACCCCCTTATTTCTAGGACYATGAG

AATCGAACCCATCCCTGAGA′]

1220
m.14709T > C
4556
MT-TE
[′CGGACTACAACCACGACCAATGATAYGAAA

AACCATCGTTGTATTTCAACT′]

1221
m.14674T > C
4556
MT-TE
[′TCAACAGAAACAAAGCATACATCATBATTCT

CGCACGGACTACAACCACGA′]

1222
m.5692T > C
4570
MT-TN
[′GGGACTTAAACCCACAAACACTTAGYTAAC

AGCTAAGCACCCTAATCAACT′]

1223
m.5728T > C
4570
MT-TN
[′GCACCCTAATCAACTGGCTTCAATCYACTTC

TCCCGCCGCCGGGAAAAAAG′]

1224
m.2991T > C
4550
MT-RNR2
[′TCAACAATAGGGTTTACGACCTCGAYGTTGG

ATCAGGACATCCCGATGGTG′]

1225
m.1291T > C
4549
MT-RNR1
[′ATCTTCAGCAAACCCTGATGAAGGCYACAA

AGTAAGCGCAAGTACCCACGT′]

1226
m.1095T > C
4549
MT-RNR1
[′CTGGGATTAGATACCCCACTATGCTYAGCCC

TAAACCTCAACAGTTAAATC′]

1227
m.8528T > C
−1
—
[′TTATAACAAACCCTGAGAACCAAAAYGAAC

GAAAATCTGTTCGCTTCATTC′]

1228
m.8993T > C
4508
MT-ATP6
[′AGCCTACTCATTCAACCAATAGCCCBGGCCG

TACGCCTAACCGCTAACATT′]

1229
m.9101T > C
4508
MT-ATP6
[′ATTAACCTTCCCTCTACACTTATCAYCTTCA

CAATTCTAATTCTACTGACT′]

1230
m.9176T > C
4508
MT-ATP6
[′ATCCAAGCCTACGTTTTCACACTTCBAGTAA

GCCTCTACCTGCACGACAAC′]

1231
m.8851T > C
4508
MT-ATP6
[′AAACCTAGCCATGGCCATCCCCTTAYGAGC

GGGCACAGTGATTATAGGCTT′]

1232
m.9185T > C
4508
MT-ATP6
[′TACGTTTTCACACTTCTAGTAAGCCYCTACC

TGCACGACAACACATAATGA′]

1233
m.7587T > C
4513
MT-CO2
[′ATAGGCTAAATCCTATATATCTTAAYGGCAC

ATGCAGCGCAAGTAGGTCTA′]

1234
m.6742T > C
4512
MT-CO1
[′GGTATGGTCTGAGCTATGATATCAAYTGGCT

TCCTAGGGTTTATCGTGTGA′]

1235
m.6721T > C
4512
MT-CO1
[′AAAGAACCATTTGGATACATAGGTAYGGTC

TGAGCTATGATATCAATTGGC′]

1236
m.7275T > C
4512
MT-CO1
[′CATGAAACATCCTATCATCTGTAGGYTCATT

CATTTCTCTAACAGCAGTAA′]

1237
m.15572T > C
4519
MT-CYB
[′CATCAAGCCCGAATGATATTTCCTAYTCGCC

TACACAATTCTCCGATCCGT′]

1238
m.15197T > C
4519
MT-CYB
[′GGCCACAGTAATTACAAACTTACTAYCCGCC

ATCCCATACATTGGGACAGA′]

1239
m. 14849T > C
4519
MT-CYB
[′CATCTCCGCATGATGAAACTTCGGCYCACTC

CTTGGCGCCTGCCTGATCCT′]

1240
NC_012920.1: m.14484T > C
4541
MT-ND6
[′GCTGTAGTATATCCAAAGACAACCAYCATTC

CCCCTAAATAAATTAAAAAA′]

1241
m. 14487T > C
4541
MT-ND6
[′GTAGTATATCCAAAGACAACCATCAYTCCCC

CTAAATAAATTAAAAAAACT′]

1242
m.12706T > C
4540
MT-ND5
[′ATCAGTTCTTCAAATATCTACTCATYTTCCT

AATTACCATACTAATCTTAG′]

1243
m.10563T > C
4539
MT-ND4L
[′CTCACACCTCATATCCTCCCTACTAYGCCTA

GAAGGAATAATACTATCGCT′]

1244
m.10663T > C
4539
MT-ND4L
[′ATATTGTGCCTATTGCCATACTAGTYTTTGC

CGCCTGCGAAGCAGCGGTNG′]

1245
m.10191T > C
4537
MT-ND3
[′TTACGAGTGCGGCTTCGACCCTATAYCCCCC

GCCCGCGTCCCTTTCTCCAT′]

1246
m.10158T > C
4537
MT-ND3
[′ACAACTCAACGGCTACATAGAAAAAYCCAC

CCCTTACGAGTGCGGCTTCGA′]

1247
m.4681T > C
4536
MT-ND2
[′CAAGCAACCGCATCCATAATCCTTCYAATAG

CTATCCTCTTCAACAATATA′]

1248
m.4160T > C
4535
MT-ND1
[′TACCCCCGATTCCGCTACGACCAACYCATAC

ACCTCCTATGAAAAAACTTC′]

1249
m.3394T > C
4535
MT-ND1
[′GCTTACCGAACGAAAAATTCTAGGCYATAT

ACAACTACGCAAAGGCCCCAA′]

1250
m.3308T > C
4535
MT-ND1
[′GGTTCAATTCCTCTTCTTAACAACABACCCA

TGGCCAACCTCCTACTCCTC′]

1251
m.3949T > C
4535
MT-ND1
[′ACTAGTCTCAGGCTTCAACATCGAAYACGCC

GCAGGCCCCTTCGCCCTATT′]

1252
NM_003140.2(SRY): c.326T > C
6736
SRY
[′CTTACTGAAGCCGAAAAATGGCCATYCTTCC

(p.Phe109Ser)

AGGAGGCACAGAAATTACAG′]

1253
NM_003140.2(SRY): c.203T > C
6736
SRY
[′GTGAAGCGACCCATGAACGCATTCAYCGTG

(p.Ile68Thr)

TGGTCTCGCGATCAGAGGCGC′]

1254
NM_021083.2(XK): c.880T > C
7504
XK
[′ACTCTATACTGGTATCAACATGTTCNGCTGG

(p.Cys294Arg)

TCTGCTGTACAGCTGAAAAT′]

1255
NM_000354.5(SERPINA7):
6906
SERPINA7
[′CACCAGATGGAACAATACTATCACCYAGTG

c.740T > C (p.Leu247Pro)

GATATGGAATTGAACTGCACA′]

1256
NM_000044.3(AR): c.2033T > C
367
AR
[′TGTCAGCCCATCTTTCTGAATGTCCYGGAAG

(p.Leu678Pro)

CCATTGAGCCAGGTGTAGTG′]

1257
NM_000044.3(AR): c.2423T > C
367
AR
[′ATCACCCCCCAGGAATTCCTGTGCAYGAAA

(p.Met808Thr)

GCACTGCTACTCTTCAGCATT′]

1258
NM_000044.3(AR): c.2596T > C
367
AR
[′CTACCAGCTCACCAAGCTCCTGGACYCCGTG

(p.Ser866Pro)

CAGCCTGTAAGCAAACGATG′]

1259
NM_000451.3(SHOX): c.877T > C
6473
SHOX
[′GAAGCACGCGGAGGCCCTGGGGCTCYGACC

(p.Ter293Arg)

CGCCGCGCAGCCCCCCGCGCG′]

1260
NM_000330.3(RS1): c.286T > C
−1
—
[′TTGAGCCGGGCCTTGTTTGCAGTCCRCGAAG

(p.Trp96Arg)

AATACCAGCCCACATACTGC′]

1261
NM_000330.3(RS1): c.38T > C
6247
RS1
[′ATAGAAGGCTTTTTGTTATTACTTCYCTTTG

(p.Leu13Pro)

GCTATGAAGGTATGTGCTAT′]

1262
NM_000330.3(RS1): c.667T > C
−1
—
[′CCGAGCTGAGGCAGGCATCAGGCACRCTTG

(p.Cys223Arg)

CTGACGCACTCCAGCAGCTCC′]

1263
NM_002764.3(PRPS1): c.344T >
5631
PRPS1
[′ATCTCAGCCAAGCTTGTTGCAAATAYGCTAT

C (p.Met115Thr)

CTGTAGCAGGTGCAGATCAT′]

1264
NM_002764.3(PRPS1): c.455T >
5631
PRPS1
[′AATTTGTATGCAGAGCCGGCTGTCCYAAAGT

C (p.Leu152Pro)

GGATAAGGGAGAATATCTCT′]

1265
NM_002764.3(PRPS1): c.869T >
5631
PRPS1
[′TTTCCTTTCTTGCCTTTCTAGGTGAYTGACAT

C (p.Ile290Thr)

CTCTATGATCCTTGCAGAA′]

1266
NM_000291.3(PGK1): c.263T > C
5230
PGK1
[′CCAGTTGCTGTAGAACTCAAATCTCYGCTGG

(p.Leu88Pro)

GCAAGTAAGTGCCAGGCTCT′]

1267
NM_000291.3(PGK1): c.946T > C
5230
PGK1
[′CACCTCTACCCCTCAGGGCTTGGACYGTGGT

(p.Cys316Arg)

CCTGAAAGCAGCAAGAAGTA′]

1268
NM_000291.3(PGK1): c.758T > C
5230
PGK1
[′CATCATTTTGGCTCCCCTGTGTAGAYTGGCA

(p.Ile253Thr)

CTTCTCTGTTTGATGAAGAG′]

1269
NM_001122606.1(LAMP2):
3920
LAMP2
[′CATTGCAAATAACAATCTCAGCTACYGGGA

c.961T > C (p.Trp321Arg)

TGCCCCCCTGGGAAGTTCTTA′]

1270
NM_000206.2(IL2RG): c.343T >
3561
IL2RG
[′ATTCTCTGAAGAAATCACTTCTGGCYGTCAG

C (p.Cys115Arg)

TTGCAAAAAAAGGAGATCCA′]

1271
NM_000206.2(IL2RG): c.452T >
3561
IL2RG
[′ACACAGATGCTAAAACTGCAGAATCYGGGT

C (p.Leu151Pro)

AATTTGGAAAGAAAGGGTCAA′]

1272
NM_000194.2(HPRT1): c.122T >
3251
HPRT1
[′GAAAGGGTGTTTATTCCTCATGGACYAATTA

C (p.Leu41Pro)

TGGACAGGTAAGTAAGATCT′]

1273
NM_000194.2(HPRT1): c.170T >
3251
HPRT1
[′CTTGCTCGAGATGTGATGAAGGAGAYGGGA

C (p.Met57Thr)

GGCCATCACATTGTAGCCCTC′]

1274
NM_000132.3(F8): c.6554T > C
2157
F8
[′ATTCGCAGCACTCTTCGCATGGAGTYGATGG

(p.Leu2185Ser)

GCTGTGATTTAAATAGTAAG′]

1275
NM_000132.3(F8): c.985T > C
2157
F8
[′GGACCTTGGACAGTTTCTACTGTTTYGTCAT

(p.Cys329Arg)

ATCTCTTCCCACCAACATGG′]

1276
NM_000132.3(F8): c.5372T > C
2157
F8
[′AGAGCAGAAGTTGAAGATAATATCAYGGTG

(p.Met1791Thr)

AGTTAAGGACAGTGGAATTAC′]

1277
NM_000132.3(F8): c.1754T > C
2157
F8
[′CCTTTCAATATATGTAATTAACAGAYAATGT

(p.Ile585Thr)

CAGACAAGAGGAATGTCATC′]

1278
NM_000132.3(F8): c.935T > C
2157
F8
[′TCCTTGGAAATCTCGCCAATAACTTYCCTTA

(p.Phe312Ser)

CTGCTCAAACACTCTTGATG′]

1279
NM_000132.3(F8): c.980T > C
2157
F8
[′TTGATGGACCTTGGACAGTTTCTACYGTTTT

(p.Leu327Pro)

GTCATATCTCTTCCCACCAA′]

1280
NM_000132.3(F8): c.1174T > C
2157
F8
[′CTCTCCTTCCTTTATCCAAATTCGCYCAGTTG

(p.Ser392Pro)

CCAAGAAGCATCCTAAAAC′]

1281
NM_000132.3(F8): c.1417T > C
2157
F8
[′ATCAGGAATCTTGGGACCTTTACTTYATGGG

(p.Tyr473His)

GAAGTTGGAGACACACTGTT′]

1282
NM_000132.3(F8): c.1481T > C
2157
F8
[′AATCAAGCAAGCAGACCATATAACAYCTAC

(p.Ile494Thr)

CCTCACGGAATCACTGATGTC′]

1283
NM_000132.3(F8): c.1729T > C
2157
F8
[′CCCTCTCCTCATCTGCTACAAAGAAYCTGTA

(p.Ser577Pro)

GATCAAAGAGGAAACCAGGT′]

1284
NM_000132.3(F8): c.1958T > C
2157
F8
[′CAGTTGTCAGTTTGTTTGCATGAGGYGGCAT

(p.Val653Ala)

ACTGGTACATTCTAAGCATT′]

1285
NM_000132.3(F8): c.2029T > C
2157
F8
[′TTCTGTCTTCTTCTCTGGATATACCYTCAAAC

ACAAAATGGTCTATGAAGA′]

1286
NM_000132.3(F8): c.6193T > C
2157
F8
[′GTTTCTTTACTTGGGCAAAGGACAGYGGGCC

CCAAAGCTGGCCAGACTTCA′]

1287
NM_007325.4(GRIA3): c.2117T >
2892
GRIA3
[′GTGTACGAGAAAATGTGGTCTTACAYGAAA

C (p.Met706Thr)

TCAGCGGAGCCATCTGTGTTT′]

1288
NM_000402.4(G6PD): c.1058T >
2539
G6PD
[′GAGGGCGAGGCCACCAAAGGGTACCYGGAC

C (p.Leu353Pro)

GACCCCACGGTGCCCCGCGGG′]

1289
NM_000402.4(G6PD): c. 1054T >
2539
G6PD
[′TGGAGAGGGCGAGGCCACCAAAGGGYACCT

C (p.Tyr352His)

GGACGACCCCACGGTGCCCCG′]

1290
NM_001097642.2(GJB1):
2705
GJB1
[′GGTCCACATCTCAGGGACACTGTGGYGGAC

c.397T > C (p.Trp133Arg)

CTATGTCATCAGCGTGGTGTT′]

1291
NM_000166.5(GJB1): c.407T > C
2705
GJB1
[′TCAGGGACACTGTGGTGGACCTATGYCATC

(p. Val136Ala)

AGCGTGGTGTTCCGGCTGTTG′]

1292
NM_000032.4(ALAS2): c.595T >
212
ALAS2
[′TGTGTCCGTCTGGTGTAGTAATGATYACCTG

C (p.Tyr199His)

GGCATGAGCCGACACCCTCA′]

1293
NM_020061.5(OPNILW):
5956
OPNILW
[′CTGGCCCCACGGCCTGAAGACTTCAYGCGG

c.607T > C (p.Cys203Arg)

CCCAGACGTGTTCAGCGGCAG′]

1294
NM_000513.2(OPN1MW):
2652
OPN1MW
[′CTGGCCCCACGGCCTGAAGACTTCAYGCGG

c.607T > C (p.Cys203Arg)

CCCAGACGTGTTCAGCGGCAG′]

1295
NM_000513.2(OPN1MW):
2652
OPN1MW
[′GGCCATCGTGGGCATTGCCTTCTCCYGGATC

c.529T > C (p.Trp177Arg)

TGGGCTGCTGTGTGGACAGC′]

1296
NM_000273.2(GPR143): c.397T >
4935
GPR143
[′GCTGTTGTACAGTGCCTGCTTCTGGHGGCTG

C (p.Trp133Arg)

TTTTGCTATGCAGTGGATGC′]

1297
NM_000133.3(F9): c.52T > C
2158
F9
[′AGAATCACCAGGCCTCATCACCATCYGCCTT

(p.Cys18Arg)

TTAGGATATCTACTCAGTGC′]

1298
NM_000133.3(F9): c.1058T > C
2158
F9
[′TTCCTCAAATTTGGATCTGGCTATGYAAGTG

(p.Val353Ala)

GCTGGGGAAGAGTCTTCCAC′]

1299
NM_000133.3(F9): c.1144T > C
2158
F9
[′AGTTCCACTTGTTGACCGAGCCACAHGTCTT

(p.Cys382Arg)

CGATCTACAAAGTTCACCAT′]

1300
NM_000133.3(F9): c.1328T > C
2158
F9
[′TGTGCAATGAAAGGCAAATATGGAAYATAT

(p.Ile443Thr)

ACCAAGGTATCCCGGTATGTC′]

1301
NM_000133.3(F9): c.1357T > C
2158
F9
[′TACCAAGGTATCCCGGTATGTCAACYGGATT

(p.Trp453Arg)

AAGGAAAAAACAAAGCTCAC′]

1302
NM_000133.3(F9): c.82T > C
2158
F9
[′TTTAGGATATCTACTCAGTGCTGAAYGTACA

(p.Cys28Arg)

GGTTTGTTTCCTTTTTTAAA′]

1303
NM_000133.3(F9):
2158
F9
[′CTGAATTTTGGAAGCAGTATGTTGGYAAGC

c.277 + 2T > C

AATTCATTTTATCCTCTAGCT′]

1304
NM_000133.3(F9): c.1031T > C
2158
F9
[′ATTGCTGACAAGGAATACACGAACAYCTTC

(p.Ile344Thr)

CTCAAATTTGGATCTGGCTAT′]

1305
NM_000169.2(GLA): c.484T > C
−1
—
[′CATTGATGCCCAGACCTTTGCTGACYGGGGA

(p.Trp162Arg)

GTAGATCTGCTAAAATTTGA′]

1306
NM_000169.2(GLA): c.806T > C
−1
—
[′TTATTTCATTCTTTTTCTCAGTTAGYGATTGG

(p.Val269Ala)

CAACTTTGGCCTCAGCTGG′]

1307
NM_015107.2(PHF8): c.836T > C
23133
PHF8
[′CCAACAAATGCCAATCTGACTCTCTYTGAGT

(p.Phe279Ser)

GCTGGAGCAGTTCCTCTAAT′]

1308
NM_033290.3(MID1): c.1877T >
4281
MID1
[′TATGATGCTTTGAACTCCATCCACCYCTACA

C (p.Leu626Pro)

CCTTCGACGTCGCATTTGCG′]

1309
NM_033290.3(MID1): c.884T > C
4281
MID1
[′TTCAAGGTGATGAGGCTTCGCAAACYGGCT

(p.Leu295Pro)

CAGCAGATTGCAAACTGCAAA′]

1310
NM_000444.5(PHEX): c.755T > C
5251
PHEX
[′CAGTATCGGGATGCCCTTTACAAGTYCATGG

(p.Phe252Ser)

TGGATACTGCCGTGCTTTTA′]

1311
NM_000444.5(PHEX): c. 1664T >
5251
PHEX
[′CTCATAGGATTTCCAGCAGGAGAGCYCCAG

C (p.Leu555Pro)

AAGCCTTTCTTTTGGGGAACA′]

1312
NM_001205019.1(GK): c.1525T >
2710
GK
[′AGAAAGTGAAATTCGTTATTCTACAYGGAA

C (p.Trp509Arg)

GAAAGCTGTGATGAAGTCAAT′]

1313
NM_000475.4(NROB1): c.890T >
190
NROB1
[′AACTGCTGGGCGTCCCTGCTCATGCYTGAGC

C (p.Leu297Pro)

TGGCCCAGGACCGCTTGCAG′]

1314
NM_000531.5(OTC): c.332T > C
5009
OTC
[′CTTCTGGGAGGACATCCTTGTTTTCYTACCA

(p.Leul11Pro)

CACAAGATATTCATTTGGGT′]

1315
NM_000531.5(OTC): c.134T > C
5009
OTC
[′CTGAAGGGCCGTGACCTTCTCACTCYAAAA

(p.Leu45Pro)

AACTTTACCGGAGAAGAAATT′]

1316
NM_000531.5(OTC):
5009
OTC
[′TTGGCAGAGCAGTATGCCAAAGAGGYATGC

c.717 + 2T > C

TCTTTACATGTAAAGCTATTA′]

1317
NM_001399.4(EDA): c.181T > C
1896
EDA
[′CCTCCACCTGCTGACGTTGTGCTGCYACCTA

(p.Tyr61His)

GAGTTGCGCTCGGAGTTGCG′]

1318
NM_001015877.1(PHF6): c.2T >
84295
PHF6
[′CATTCTAAAGGCAATTTAAAAATCAYGTCA

C (p.Met1Thr)

AGCTCAGTTGAACAGAAAAAA′]

1319
NM_001128834.2(PLP1):
5354
PLP1
[′CATCACCTATGCCCTGACCGTTGTGYGGCTC

c.487T > C (p.Trp163Arg)

CTGGTGTTTGCCTGCTCTGC′]

1320
NM_001128834.2(PLP1):
5354
PLP1
[′CCTGGCAAGGTTTGTGGCTCCAACCYTCTGT

c.671T > C (p.Leu224Pro)

CCATCTGCAAAACAGCTGAG′]

1321
NM_001128834.2(PLP1):
5354
PLP1
[′AACACCTGGACCACCTGCCAGTCTAYTGCCT

c.560T > C (p.Ile187Thr)

TCCCCAGCAAGACCTCTGCC′]

1322
NM_001128834.2(PLP1):
5354
PLP1
[′ATTTTCCTGCAGTTCCAAATGACCTYCCACC

c.710T > C (p.Phe237Ser)

TGTTTATTGCTGCATTTGTG′]

1323
NM_000116.4(TAZ): c.352T > C
6901
TAZ
[′CTCCCACTTCTTCAGCTTGGGCAAGYGTGTG

(p.Cys118Arg)

CCTGTGTGCCGAGGTGAGCT′]

1324
NM_000377.2(WAS): c.244T > C
7454
WAS
[′CTTCGTGAAGGATAACCCCCAGAAGYCCTA

(p.Ser82Pro)

CTTCATCCGCCTTTACGGCCT′]

1325
NM_000377.2(WAS): c.809T > C
7454
WAS
[′AACCTCGACCCAGATCTGCGGAGTCYGTTCT

(p.Leu270Pro)

CCAGGGCAGGAATCAGCGAG′]

1326
NM_182680.1(AMELX): c.2T > C
−1
—
[′CTTACATTTCAGAACCATCAAGAAAYGGGG

(p.Met1Thr)

ACCTGGATTTTATTTGCCTGC′]

1327
NM_000074.2(CD40LG):
959
CD40LG
[′ACCATGAGCAACAACTTGGTAACCCYGGAA

c.464T > C (p.Leu155Pro)

AATGGGAAACAGCTGACCGTT′]

1328
NM_139058.2(ARX): c.98T > C
170302
ARX
[′TCCTCCTACTGCATCGACAGCATCCYGGGCC

(p.Leu33Pro)

GGAGGAGCCCGTGCAAAATG′]

1329
NM_001109878.1(TBX22):
50945
TBX22
[′TGATCATTTCTCCTCCAGATCATTCYGCAAT

c.641T > C (p.Leu214Pro)

CCATGCATAAGTACAAACCC′]

1330
NM_000061.2(BTK): c.2T > C
695
BTK
[′GGTGAACTCCAGAAAGAAGAAGCTAYGGCC

(p.Met1Thr)

GCAGTGATTCTGGAGAGCATC′]

1331
NM_000061.2(BTK): c.1223T > C
695
BTK
[′AAGGACCTGACCTTCTTGAAGGAGCYGGGG

(p.Leu408Pro)

ACTGGACAATTTGGGGTAGTG′]

1332
NM_000061.2(BTK): c.1516T > C
695
BTK
[′GCTGCTAGAGATGTGCAAGGATGTCYGTGA

(p.Cys506Arg)

AGCCATGGAATACCTGGAGTC′]

1333
NM_000061.2(BTK): c.1625T > C
695
BTK
[′GTTGTTAAAGTATCTGATTTCGGCCYGTCCA

(p.Leu542Pro)

GGTGAGTGTGGCTTTTTCAT′]

1334
NM_000061.2(BTK): c.1741T > C
695
BTK
[′CAAGTTCAGCAGCAAATCTGACATTYGGGC

(p.Trp581Arg)

TTTTGGTAAGTGGATAAGATT′]

1335
NM_000061.2(BTK): c.1955T > C
695
BTK
[′TTCAAAATTCTTCTGAGCAATATTCYAGATG

(p.Leu652Pro)

TCATGGATGAAGAATCCTGA′]

1336
NM_015884.3(MBTPS2):
51360
MBTPS2
[′GATGGACAATGGATTCTAAACTCTTYCTTGG

c.1424T > C (p.Phe475Ser)

ATGCCACCCTTACCTCAGTG′]

1337
NM_014009.3(FOXP3): c.970T >
50943
FOXP3
[′GATTCATCCCCACCCTCTGACAGAGYTCCTC

C (p.Phe324Leu)

CACAACATGGACTACTTCAA′]

1338
NM_014009.3(FOXP3):
50943
FOXP3
[′GACACTCAATGAGATCTACCACTGGYTCAC

c.1099T > C (p.Phe367Leu)

ACGCATGTTTGCCTTCTTCAG′]

1339
NM_022567.2(NYX): c.302T > C
60506
NYX
[′CTGCGCCACAACAACCTGTCCTTCAYCACGC

(p.Ile101Thr)

CCGGCGCCTTCAAGGGCCTG′]

1340
NM_003639.4(IKBKG):
8517
IKBKG
[′CACCCTGCAGATACATGTCATGGAGYGCATT

c.1249T > C (p.Cys417Arg)

GAGTAGGGCCGGCCAGTGCA′]

1341
NM_006579.2(EBP): c.53T > C
10682
EBP
[′CCATACTGGCCTCAGCACCTAAGACYGGAC

(p.Leu18Pro)

AACTTTGTACCTAATGACCGC′]

1342
NM_003159.2(CDKL5): c.215T >
6792
CDKL5
[′CTTCGGACTCTCAAGCAGGAAAACAHTGTG

C (p.Ile72Thr)

GAGTTGAAGGAAGCATTTCGT′]

1343
NM_001011658.3(TRAPPC2):
−1
—
[′GCCTTAATTATTTCACATATGAGGTYTATTA

c.248T > C (p.Phe83Ser)

TGCTTCATGACATAAGACAA′]

1344
NM_001011658.3(TRAPPC2):
−1
—
[′AGTTACCTTTACTAAGAAGGTAAGGRTATGC

238 + 4T > C

CCCGCAGTGACAAATGCCGA′]

1345
NM_003688.3(CASK): c.802T > C
8573
CASK
[′GGATCCAGCTGAAAGGATCACTGTTYATGA

(p.Tyr268His)

AGCACTGAATCACCCATGGCT′]

1346
NM_003688.3(CASK): c.2740T >
8573
CASK
[′TGAGCTCGTGTGCACAGCCCCACAGYGGGT

C (p.Trp914Arg)

CCCTGTCTCCTGGGTCTATTA′]

1347
NM_001159702.2(FHL1):
2273
FHL1
[′AGGGGAGGACTTCTACTGCGTGACTYGCCA

c.457T > C (p.Cys153Arg)

TGAGACCAAGTTTGCCAAGCA′]

1348
NM_001159702.2(FHL1):
2273
FHL1
[′GGAGGACTCCCCCAAGTGCAAGGGGYGCTT

c.310T > C (p.Cys104Arg)

CAAGGCCATTGTGGCAGGTAC′]

1349
NM_001159702.2(FHL1):
2273
FHL1
[′CACCGCTGTGGAGGACCAGTATTACYGCGT

c.625T > C (p.Cys209Arg)

GGATTGCTACAAGAACTTTGT′]

1350
NM_001363.4(DKC1): c.113T > C
1736
DKC1
[′ATACAACACGCTGAAGAATTTCTTANCAAA

(p.Ile38Thr)

CCTGAATCCAAAGTTGCTAAG′]

1351
NM_178152.2(DCX): c.373T > C
1641
DCX
[′CTTATTTCTTGCCTTAGGGGAAAGCYATGTC

(p.Tyr125His)

TGTTCCTCAGACAACTTCTT′]

1352
NM_005183.3(CACNA1F):
778
CACNAIF
[′ATCCTGTTGAACGTGTTTCTTGCCAYTGCTG

c.2267T > C (p.Ile756Thr)

TGGACAACCTGGCCAGTGGA′]

1353
NM_001493.2(GDI1): c.275T > C
2664
GDI1
[′ACAGGGCAGCTGGTAAAGATGCTACYGTAT

(p.Leu92Pro)

ACAGAGGTGACTCGCTACCTG′]

1354
NM_006517.4(SLC16A2):
6567
SLC16A2
[′ATCATGGCCCCCATTGCATTTGAGCYGGTGG

c.1313T > C (p.Leu438Pro)

GCCCAATGCAGGCCTCACAG′]

1355
NM_006517.4(SLC16A2):
6567
SLC16A2
[′CTCCAGGTCCTTTCCTTCCTGCTCCYGGGCC

c.1190T > C (p.Leu397Pro)

TGATGTCCATGATGATTCCC′]

1356
NM_006517.4(SLC16A2):
6567
SLC16A2
[′CCCCCCATCATCGGGGCTGTAATCCYCTTCT

c.1481T > C (p.Leu494Pro)

TCGTCCCTCTGATGCATCAA′]

1357
NM_004586.2(RPS6KA3):
6197
RPS6KA3
[′GAAATGCTTACTGGTACACTCCCTTYCCAAG

c.803T > C (p.Phe268Ser)

GAAAAGATCGAAAAGAAACA′]

1358
NM_000489.4(ATRX): c.4840T >
546
ATRX
[′AAGTTTTCTTCATACAGTTCTTTTGYGTGAC

C (p.Cys1614Arg)

AAACTGGATTTCAGCACGGC′]

1359
NM_000489.4(ATRX): c.6250T >
546
ATRX
[′GAAGTGGCTTCGAAACATTGACTATYACCGT

C (p.Tyr2084His)

TTAGATGGTTCCACTACTGC′]

1360
NM_000489.4(ATRX): c.1226T >
546
ATRX
[′GATATTAAGAAGGCTCATCTTGCATYGGAA

C (p.Leu409Ser)

GAAGACTTAAATTCCGAGTTT′]

1361
NM_000489.4(ATRX): c.6149T >
546
ATRX
[′CAGTCCCTCATATCTCTGGACTTGAYTGAAG

C (p.Ile2050Thr)

ATTTTCTTGAATTAGCTAGT′]

NM_001110556.1(FLNA):
2316
FLNA

c.720 + 2T > C

1362
NM_001127899.3(CLCN5):
1184
CLCN5
[′AGGTGGGGTGACTCGGATGACTGTTYCTCTT

6c.178T > C (p.Ser590Pro)

GTTGTCATAATGTTTGAACT′]

1363
NM_004992.3(MECP2): c.464T >
4204
MECP2
[′GACACATCCCTGGACCCTAATGATTBTGACT

C (p.Phe155Ser)

TCACGGTAACTGGGAGAGGG′]

1364
NM_001061.4(TBXAS1):
6916
TBXAS1
[′TGCCTCGGGGTGCGTCTAGGGCTGCYTGAG

c.1463T > C (p.Leu488Pro)

GTCAAGTTGACACTGCTCCAC′]

1365
NM_001061.4(TBXAS1):
6916
TBXAS1
[′TTTTTTATTCCTCCCAGGTACTATCYTGGTCG

c.248T > C (p.Leu83Pro)

TCGGATGTTTATTGTTATT′]

1366
NM_000128.3(F11): c.901T > C
2160
F11
[′TTCTTCATTTTACCATGACACTGATYTCTTGG

(p.Phe301Leu)

GAGAAGAACTGGATATTGT′]

1367
NM_000128.3(F11): c.166T > C
2160
F11
[′GGTAGTCTGCACTTACCACCCAAGAYGTTTA

(p.Cys56Arg)

CTCTTCACTTTCACGGCGGA′]

1368
NM_000203.4(IDUA): c.1469T >
3425
IDUA
[′AGCCCCGACGGCGAGTGGCGGCGCCYGGGC

C (p.Leu490Pro)

CGGCCCGTCTTCCCCACGGCA′]

1369
NM_000431.3(MVK): c.803T > C
4598
MVK
[′ATCGTGGCCCCCCTCCTGACCTCAAYAGATG

(p.Ile268Thr)

CCATCTCCCTGGAGTGTGAG′]

1370
NM_014425.3(INVS): c.1478T >
27130
INVS
[′TTATGCTTATAGGGAAGAACAGCTTYGCATT

C (p.Leu493Ser)

GGTCCTGCAACAATGGATAC′]

1371
NM_000108.4(DLD): c.1178T > C
1738
DLD
[′GACTACAATTGTGTGCCATCAGTGAYTTACA

(p.Ile393Thr)

CACACCCTGAAGTTGCTTGG′]

1372
NM_000170.2(GLDC): c.2T > C
2731
GLDC
[′GGGCAGGGGACGGTGGCCGCGGCCAYGCAG

(p.Met1Thr)

TCCTGTGCCAGGGCGTGGGGG′]

1373
NM_000151.3(G6PC): c.229T > C
2538
G6PC
[′AGACTGGCTCAACCTCGTCTTTAAGYGGTAA

(p.Trp77Arg)

GAACCATATAGAGAGGAGAT′]

1374
NM_004453.3(ETFDH): c.2T > C
2110
ETFDH
[′CCGAGAGTCCTGGTGACTTTGAACAYGCTG

(p.Met1Thr)

GTGCCGCTAGCCAAGCTGTCC′]

1375
NM_000136.2(FANCC):
−1
—
[′CTGGCCCGAGAGCTCCTTAAAGAGCYGCGA

c.1661T > C (p.Leu554Pro)

ACTCAAGTCTAGAAGGCACGC′]

1376
NM_000131.4(F7): c.38T > C
2155
F7
[′GCCCTCAGGCTCCTCTGCCTTCTGCYTGGGC

(p.Leu13Pro)

TTCAGGGCTGCCTGGCTGCA′]

1377
NM_000131.4(F7): c.983T > C
2155
F7
[′CCCCTCTGCCTGCCCGAACGGACGTYCTCTG

(p.Phe328Ser)

AGAGGACGCTGGCCTTCGTG′]

1378
NM_024649.4(BBS1): c.1553T >
−1
—
[′ACAACCCGTCCTGTCCTGGGGCTGCYGGTCT

C (p.Leu518Pro)

GCTTCCTGTACAACGAGGCG′]

1379
NM_000490.4(AVP): c.200T > C
551
AVP
[′TGCGCGGACGAGCTGGGCTGCTTCGYGGGC

(p.Val67Ala)

ACGGCTGAGGCGCTGCGCTGC′]

1380
NM_000490.4(AVP): c.61T > C
551
AVP
[′CCTACTGGCCTTCTCCTCCGCGTGCYACTTC

(p.Tyr21His)

CAGAACTGCCCGAGGGGCGG′]

1381
NM_001692.3(ATP6V1B1):
525
ATP6V1B1
[′GGGACTCAGAGGAGCGGGCAGGTGCYTGAG

c.242T > C (p.Leu81Pro)

GTGGCTGGCACCAAGGCGATT′]

1382
NM_003361.3(UMOD): c.649T >
7369
UMOD
[′GGGCGGTGCGCGCATGGCCGAGACCBGCGT

C (p.Cys217Arg)

GCCAGTCCTGCGCTGCAACAC′]

1383
NM_003361.3(UMOD): c.376T >
7369
UMOD
[′TAGCCACTGCCACGCCCTGGCCACAYGTGTC

C (p.Cys126Arg)

AATGTGGTGGGCAGCTACTT′]

1384
NM_003361.3(UMOD): c.943T >
7369
UMOD
[′CAAATCGAATAATGGCAGATGGCACYGCCA

C (p.Cys315Arg)

GTGCAAACAGGACTTCAACAT′]

1385
NM_080911.2(UNG): c.752T > C
7374
UNG
[′AATCAGAACTCGAATGGCCTTGTTTYCTTGC

(p.Phe251Ser)

TCTGGGGCTCTTATGCTCAG′]

1386
NM_199292.2(TH): c.707T > C
7054
TH
[′CAGGTGTACCGCCAGCGCAGGAAGCYGATT

(p.Leu236Pro)

GCTGAGATCGCCTTCCAGTAC′]

1387
NM_001065.3(TNFRSF1A):
7132
TNFRSF1A
[′CCACCCTCAAAATAATTCGATTTGCYGTACC

c.175T > C (p.Cys59Arg)

AAGTGCCACAAAGGTAGGGG′]

1388
NM_001065.3(TNFRSF1A):
7132
TNFRSF1A
[′AATGGGTCAGGTGGAGATCTCTTCTYGCACA

c.349T > C (p.Cys117Arg)

GTGGACCGGGACACCGTGTG′]

1389
NM_000546.5(TP53): c.755T > C
7157
TP53
[′GGCGGCATGAACCGGAGGCCCATCCYCACC

(p.Leu252Pro)

ATCATCACACTGGAAGACTCC′]

1390
NM_000546.5(TP53): c.398T > C
7157
TP53
[′CAGTACTCCCCTGCCCTCAACAAGAYGTTTT

(p.Met133Thr)

GCCAACTGGCCAAGACCTGC′]

1391
NM_000546.5(TP53): c.1031T > C
7157
TP53
[′GAGCGCTTCGAGATGTTCCGAGAGCYGAAT

(p.Leu344Pro)

GAGGCCTTGGAACTCAAGGAT′]

1392
NM_001018005.1(TPM1):
7168
TPM1
[′TCTCTGAACAGACGCATCCAGCTGGYTGAG

c.284T > C (p. Val95Ala)

GAAGAGTTGGATCGTGCCCAG′]

1393
NM_001159287.1(TPI1):
7167
TPI1
[′GGGTGGTGCTTCCCTCAAGCCCGAAYTCGTG

c.832T > C (p.Phe278Leu)

GACATCATCAATGCCAAACA′]

1394
NM_003242.5(TGFBR2):
7048
TGFBR2
[′AAGCATGAGAACATACTCCAGTTCCYGACG

c.923T > C (p.Leu308Pro)

GCTGAGGAGCGGAAGACGGAG′]

1395
NM_000660.5(TGFB1): c.673T >
7040
TGFB1
[′CTTTCGCCTTAGCGCCCACTGCTCCYGTGAC

C (p.Cys225Arg)

AGCAGGGATAACACACTGCA′]

1396
NM_000660.5(TGFB1): c.241T >
7040
TGFB1
[′GCTGCCCGAGGCCGTGCTCGCCCTGYACAA

C (p.Tyr81His)

CAGCACCCGCGACCGGGTGGC′]

1397
NM_000660.5(TGFB1): c.667T >
7040
TGFB1
[′TGAGGGCTTTCGCCTTAGCGCCCACNGCTCC

C (p.Cys223Arg)

TGTGACAGCAGGGATAACAC′]

1398
NM_001128177.1(THRB):
7068
THRB
[′ATCATCCTCCTCAAAGGCTGCTGCAYGGAG

c.929T > C (p.Met310Thr)

ATCATGTCCCTTCGCGCTGCT′]

1399
NM_001128177.1(THRB):
7068
THRB
[′CCGCTTCCTGCACATGAAGGTGGAAYGCCC

c.1336T > C (p.Cys446Arg)

CACAGAACTCTTCCCCCCTTT′]

1400
NM_001128177.1(THRB):
7068
THRB
[′CTCTTCCCCCCTTTGTTCTTGGAAGYGTTCG

3c.137T > C (p.Val458Ala)

AGGATTAGACTGACTGGATT′]

1401
NM_007313.2(ABL1): c.814T > C
25
ABL1
[′GAAGCACAAGCTGGGCGGGGGCCAGYACGG

(p.Tyr272His)

GGAGGTGTACGAGGGCGTGTG′]

1402
NM_007313.2(ABL1): c.988T > C
25
ABL1
[′AGGGGTCTGCACCCGGGAGCCCCCGYTCTA

(p.Phe330Leu)

TATCATCACTGAGTTCATGAC′]

1403
NM_007313.2(ABL1): c.1109T >
25
ABL1
[′ATGGCCACTCAGATCTCGTCAGCCAYGGAG

C (p.Met370Thr)

TACCTGGAGAAGAAAAACTTC′]

1404
NM_021961.5(TEAD1):
7003
TEAD1
[′TGAACACGGAGCACAACATCATATTYACAG

c.1261T > C (p.Tyr?His)

GCTTGTAAAGGACTGAACATG′]

1405
NM_001256850.1(TTN):
7273
TTN
[′TGGATACCCATCCCCGACAGTGACAHGGTA

c.2926T > C (p.Trp976Arg)

CAGGGAAGACTACCAAATCGA′]

1406
NM_133378.4(TTN): c.100163T >
−1
—
[′GAAAACACAGATGACCTGACAACCCYGATC

C (p.Leu33388Pro)

ATCATGGACGTACAGAAACAA′]

1407
NM_003235.4(TG): c.3733T > C
7038
TG
[′CCCCACAGGCTCTGCCATGCAGCAGYGCCA

(p.Cys1245Arg)

ATTGCTGTGCCGCCAGGGCTC′]

1408
NM_003235.4(TG): c.3229T > C
7038
TG
[′TCTCTCTCCCACAGGCCCGACAACCYGCGAG

(p.Cys1077Arg)

AAATCTCGAACCAGTGGGCT′]

1409
NM_000733.3(CD3E):
916
CD3E
[′CGGGTGCTGGCGGCAGGCAAAGGGGYAAGG

c.520 + 2T > C

CTGTGGAGTCCAGTCAGAGGA′]

1410
NM_003000.2(SDHB): c.487T > C
6390
SDHB
[′GCCTTATTTGAAGAAGAAGGATGAAYCTCA

(p.Ser163Pro)

GGAAGGCAAGCAGCAGTATCT′]

1411
NM_003106.3(SOX2): c.290T > C
−1
—
[′CCGTTCATCGACGAGGCTAAGCGGCYGCGA

(p.Leu97Pro)

GCGCTGCACATGAAGGAGCAC′]

1412
NM_001024858.2(SPTB):
6710
SPTB
[′TAATGTCACCAACTTTACCTCCAGCYGGAAG

c.604T > C (p.Trp202Arg)

GATGGCTTGGCCTTTAATGC′]

1413
NM_001024858.2(SPTB):
6710
SPTB
[′GGTGTGCCAGTTCTCGAGGGATGCCYCTGTG

c.6055T > C (p.Ser2019Pro)

GCTGAGGCGTGGCTGATTGC′]

1414
NM_003126.2(SPTA1): c.779T >
6708
SPTA1
[′TTGGCTCTCCAGAGACAGAAAGCTCBGTCCA

C (p.Leu260Pro)

ATGCTGCAAACTTACAACGA′]

1415
NM_003126.2(SPTA1): c.781T >
6708
SPTA1
[′GGCTCTCCAGAGACAGAAAGCTCTGYCCAA

C (p.Ser261Pro)

TGCTGCAAACTTACAACGATT′]

1416
NM_003126.2(SPTA1): c.620T >
6708
SPTA1
[′AAATTTGAAGACTTCCAAGTGGAGCYGGTA

C (p.Leu207Pro)

GCTAAAGAAGGGAGAGTTGTT′]

1417
NM_005633.3(SOS1): c.1294T >
6654
SOS1
[′CGAGATTCAGAAGAATATTGATGGTYGGGA

C (p.Trp432Arg)

GGGAAAAGACATTGGACAGTG′]

1418
NM_006920.4(SCN1A):
−1
—
[′TGTGGAAGAAGGCAGAGGAAAACAAYGGT

c.3577T > C (p.Trp1193Arg)

GGAACCTGAGAAGGACGTGTTT′]

1419
NM_006920.4(SCN1A):
−1
—
[′TTTGGGTATCTCTCTTTGCTTCAAGYTGTAA

c.4250T > C (p.Val1417Ala)

GTGAACACTATTTTCTCTGA′]

1420
NM_006920.4(SCN1A): c.434T >
6323
SCN1A
[′ACTATTTTGACAAACTGTGTGTTTAHGACAA

C (p.Met145Thr)

TGAGTAACCCTCCTGATTGG′]

1421
NM_006920.4(SCN1A):
−1
—
[′TCTATACTTTGGAGGTCAAGACATCYTTATG

c.4462T > C (p.Phe1488Leu)

ACAGAAGAACAGAAGAAATA′]

1422
NM_152296.4(ATP1A3):
478
ATP1A3
[′GGGCTGGAGGTGGGCAAGACGCCCAHCGCC

c.821T > C (p.Ile274Thr)

ATCGAGATTGAGCACTTCATC′]

1423
NM_152296.4(ATP1A3):
478
ATP1A3
[′CAGCAATATCCCGGAGATCACGCCCYTCCTG

c.2338T > C (p.Phe780Leu)

CTGTTCATCATGGCCAACAT′]

1424
NM_000702.3(ATP1A2):
477
ATP1A2
[′CCTCAGAATCTCCCCACAGGCCGCCYGATCT

c.2291T > C (p.Leu764Pro)

TTGACAACTTGAAGAAATCC′]

1425
NM_000702.3(ATP1A2):
477
ATP1A2
[′ACGGCTACTGGGAATCCGCCTCGACYGGGA

c.2659T > C (p.Trp887Arg)

TGACCGGACCATGAATGATCT′]

1426
NM_000702.3(ATP1A2):
477
ATP1A2
[′AAGAAGGCTGACATTGGCATTGCCAYGGGC

c.2192T > C (p.Met731Thr)

ATCTCTGGCTCTGACGTCTCT′]

1427
NM_000702.3(ATP1A2):
477
ATP1A2
[′GGGCGGACACCCATAGCAATGGAGAYTGAA

c.857T > C (p.Ile286Thr)

CACTTCATCCAGCTGATCACA′]

1428
NM_001035.2(RYR2): c.1298T >
6262
RYR2
[′ATGTTTATGGTTTATTTTAGGGGCCYTGATG

C (p.Leu433Pro)

CTCTCAGCAAGAAAGCGAAG′]

1429
NM_000540.2(RYR1):
6261
RYR1
[′GTGGGTGTCCGGGCTGGCGGAGGCAYTGGG

c.14693T > C (p.Ile4898Thr)

GACGAGATCGAGGACCCCGCG′]

1430
NM_000539.3(RHO): c.133T > C
6010
RHO
[′GTTCTCCATGCTGGCCGCCTACATGYTTCTG

(p.Phe45Leu)

CTGATCGTGCTGGGCTTCCC′]

1431
NM_000321.2(RB1):
5925
RB1
[′CTCTTTCACTGTTTTATAAAAAAGGYTAGTA

c.1960 + 2T > C

GATGATTATTTTCAAGAGCA′]

1432
NM_000321.2(RB1): c.2134T > C
5925
RB1
[′TATGATGTGTTCCATGTATGGCATAYGCAAA

(p.Cys712Arg)

GTGAAGAATATAGACCTTAA′]

1433
NM_000329.2(RPE65): c.1022T >
6121
RPE65
[′AGATTTGAGTTTGTTTATAATTACTYATATTT

C (p.Leu341Ser)

AGCCAATTTACGTGAGAAC′]

1434
NM_000322.4(PRPH2): c.554T >
5961
PRPH2
[′ATTCAGTGGATCAGCAATCGCTACCYGGACT

C (p.Leu185Pro)

TTTCCTCCAAAGAAGTCAAA′]

1435
NM_000322.4(PRPH2): c.2T > C
5961
PRPH2
[′CAACCCGGACTACACTTGGCAAGCAYGGCG

(p.Met1Thr)

CTACTGAAAGTCAAGTTTGAC′]

1436
NM_001098668.2(SFTPA2):
729238
SFTPA2
[′ACTGAGGGTCCCAGCCCTGGAGACTYCCGC

c.593T > C (p.Phe198Ser)

TACTCAGATGGGACCCCTGTA′]

1437
NM_003018.3(SFTPC): c.218T >
6440
SFTPC
[′TTTCCCCAGGTTCTGGAGATGAGCAHTGGGG

C (p.Ile73Thr)

CGCCGGAAGCCCAGCAACGC′]

1438
NM_003018.3(SFTPC): c.581T >
6440
SFTPC
[′AGCACCCTGTGTGGCGAGGTGCCGCYCTACT

C (p.Leu194Pro)

ACATCTAGGACGCCTCCGGT′]

1439
NM_000055.2(BCHE): c.1004T >
590
BCHE
[′CTCACTGACATGCCAGACATATTACYTGAAC

C (p.Leu335Pro)

TTGGACAATTTAAAAAAACC′]

1440
NM_002739.3(PRKCG): c.355T >
5582
PRKCG
[′CCCCACCTTCTGCGACCACTGTGGCYCCCTC

C (p.Ser119Pro)

CTCTACGGGCTTGTGCACCA′]

1441
NM_002739.3(PRKCG):
5582
PRKCG
[′ACAGTGTGGCCGCAGCGGCGAGAACYTTGA

c.1927T > C (p.Phe643Leu)

CAAGTTCTTCACGCGGGCGGC′]

1442
NM_000141.4(FGFR2):
2263
FGFR2
[′TGTAACTTTTGAGGACGCTGGGGAAYATAC

c.1018T > C (p.Tyr340His)

GTGCTTGGCGGGTAATTCTAT′]

1443
NM_000141.4(FGFR2):
2263
FGFR2
[′TTTTGAGGACGCTGGGGAATATACGHGCTTG

c.1024T > C (p.Cys342Arg)

GCGGGTAATTCTATTGGGAT′]

1444
NM_000141.4(FGFR2): c.868T >
2263
FGFR2
[′CAGTGATGCCCAGCCCCACATCCAGBGGAT

C (p.Trp290Arg)

CAAGCACGTGGAAAAGAACGG′]

1445
NM_000141.4(FGFR2): c.799T >
2263
FGFR2
[′CCAAGCCGGACTGCCGGCAAATGCCYCCAC

C (p.Ser267Pro)

AGTGGTCGGAGGAGACGTAGA′]

1446
NM_000506.3(F2): c.1139T > C
2147
F2
[′CCTGCTGCCCCTCCCAGGCAGGTGAYGCTTT

(p.Met380Thr)

TCCGGAAGAGTCCCCAGGAG′]

1447
NM_000313.3(PROS1):
5627
PROS1
[′TTCATTATTTTAAATAGATAATGTABCCAGT

c.1501T > C (p.Ser501Pro)

GCTGAGGGTTGGCATGTAAA′]

1448
NM_002834.3(PTPN11): c.854T >
5781
PTPN11
[′TGACCGTGGTCTCTTTTTCTTCTAGNTGATCA

C (p.Phe285Ser)

TACCAGGGTTGTCCTACAC′]

1449
NM_002755.3(MAP2K1):
5604
MAP2K1
[′CAGCAGCGAAAGCGCCTTGAGGCCTYTCTT

c.158T > C (p.Phe53Ser)

ACCCAGAAGCAGAAGGTGGGA′]

1450
NM_001042465.1(PSAP):
5660
PSAP
[′GCTTTTGACAAAATGTGCTCGAAGCYGCCG

c.1055T > C (p.Leu352Pro)

AAGTCCCTGTCGGAAGAGTGC′]

1451
NM_000207.2(INS): c.143T > C
−1
—
[′TACCTAGTGTGCGGGGAACGAGGCTBCTTCT

(p.Phe48Ser)

ACACACCCAAGACCCGCCGG′]

1452
NM_000311.3(PRNP): c.593T > C
5621
PRNP
[′ACCACAACCACCAAGGGGGAGAACTYCACC

(p.Phe198Ser)

GAGACCGACGTTAAGATGATG′]

1453
NM_000371.3(TTR): c. 149T > C
7276
TTR
[′GGCAGTCCTGCCATCAATGTGGCCGBGCATG

(p.Val50Ala)

TGTTCAGAAAGGCTGCTGAT′]

1454
NM_000371.3(TTR): c.224T > C
7276
TTR
[′AGGAAAACCAGTGAGTCTGGAGAGCYGCAT

(p.Leu75Pro)

GGGCTCACAACTGAGGAGGAA′]

1455
NM_000371.3(TTR): c.88T > C
7276
TTR
[′CACCCAGGGCACCGGTGAATCCAAGYGTCC

(p.Cys30Arg)

TCTGATGGTCAAAGTTCTAGA′]

1456
NM_000371.3(TTR): c.272T > C
7276
TTR
[′GAATTTGTAGAAGGGATATACAAAGYGGAA

(p.Val91Ala)

ATAGACACCAAATCTTACTGG′]

1457
NM_000371.3(TTR): c.400T > C
7276
TTR
[′CACCATTGCCGCCCTGCTGAGCCCCYACTCC

(p.Tyr134His)

TATTCCACCACGGCTGTCGT′]

1458
NM_000371.3(TTR): c.250T > C
7276
TTR
[′GCATGGGCTCACAACTGAGGAGGAAYTTGT

(p.Phe84Leu)

AGAAGGGATATACAAAGTGGA′]

1459
NM_000371.3(TTR): c.157T > C
7276
TTR
[′TGCCATCAATGTGGCCGTGCATGTGHTCAGA

(p.Phe53Leu)

AAGGCTGCTGATGACACCTG′]

1460
NM_000371.3(TTR): c.95T > C
7276
TTR
[′GGCACCGGTGAATCCAAGTGTCCTCYGATG

(p.Leu32Pro)

GTCAAAGTTCTAGATGCTGTC′]

1461
NM_000371.3(TTR): c.191T > C
7276
TTR
[′GCTGCTGATGACACCTGGGAGCCATYTGCCT

(p.Phe64Ser)

CTGGGTAAGTTGCCAAAGAA′]

1462
NM_000371.3(TTR): c.265T > C
7276
TTR
[′TGAGGAGGAATTTGTAGAAGGGATAYACAA

(p.Tyr89His)

AGTGGAAATAGACACCAAATC′]

1463
NM_000217.2(KCNA1):
3736
KCNA1
[′ATTGCCCTGCCCGTACCTGTCATTGYGTCCA

c.1223T > C (p. Val408Ala)

ATTTCAACTATTTCTACCAC′]

1464
NM_000174.4(GP9): c.212T > C
2815
GP9
[′CTTCAGTCCGTGCCCCCGGGAGCCTBTGACC

(p.Phe71Ser)

ACCTGCCCCAGCTGCAGACC′]

1465
NM_000174.4(GP9): c.167T > C
2815
GP9
[′GCCCTGCCGGCCCGCACCCGCCACCYTCTGC

(p.Leu56Pro)

TGGCCAACAACAGCCTTCAG′]

1466
NM_000174.4(GP9): c.70T > C
2815
GP9
[′GGCCACCAAGGACTGCCCCAGCCCAYGTAC

(p.Cys24Arg)

CTGCCGCGCCCTGGAAACCAT′]

1467
NM_000174.4(GP9): c.20T > C
2815
GP9
[′TGTCCCATGCCTGCCTGGGGAGCCCYGTTCC

(p.Leu7Pro)

TGCTCTGGGCCACAGCAGAG′]

1468
NM_001001547.2(CD36):
948
CD36
[′CGATTTTTAAACAGATGCAGCCTCABTTCCA

c.760T > C (p.Phe254Leu)

CCTTTTGTTGAGAAAAGCCA′]

1469
NM_000212.2(ITGB3): c.2332T >
−1
—
[′CAACCCACTGTATAAAGAGGCCACGYCTAC

C (p.Ser778Pro)

CTTCACCAATATCACGTACCG′]

1470
NM_000212.2(ITGB3): c.176T >
3690
ITGB3
[′GCTCCTGTCTTACAGGCCCTGCCTCYGGGCT

C (p.Leu59Pro)

CACCTCGCTGTGACCTGAAG′]

1471
NM_000301.3(PLG): c.1771T > C
5340
PLG
[′AGGGGGGTGTGTGGCCCACCCACATYCCTG

(p.Ser591Pro)

GCCCTGGCAAGTCAGTCTTAG′]

1472
NM_001122757.2(POU1F1):
5449
POU1F1
[′CAAACTGAAAGCAATATTATCCAAAYGGCT

c.655T > C (p.Trp219Arg)

GGAGGAAGCTGAGCAAGTAGG′]

1473
NM_000293.2(PHKB): c.2923T >
5257
PHKB
[′ACCAACCCTGTCAGATATGACCATGHATGA

C (p.Tyr975His)

GATGAATTTCTCTCTCCTTGT′]

1474
NM_004577.3(PSPH): c.155T > C
5723
PSPH
[′CTCCCTCCTAGGACACGGCGAGCCAYGGGC

(p.Met52Thr)

GGGGCAGTGCCTTTCAAAGCT′]

1475
NM_000175.3(GPI): c.1574T > C
2821
GPI
[′CTGGGAAAGCAGCTGGCTAAGAAAABAGAG

(p.Ile525Thr)

CCTGAGCTTGATGGCAGTGCT′]

1476
NM_000175.3(GPI): c.1016T > C
2821
GPI
[′TTTGGGTGTGAGACACACGCCATGCYGCCCT

(p.Leu339Pro)

ATGACCAGTACCTGCACCGC′]

1477
NM_000478.4(ALPL): c.1306T >
249
ALPL
[′ACGAGAGAATGTCTCCATGGTGGACYATGG

C (p.Tyr436His)

TGAGACCTCCAGGACCCAGGG′]

1478
NM_000478.4(ALPL): c.979T > C
249
ALPL
[′GATCCTGCGGAAGAACCCCAAAGGCYTCTT

(p.Phe327Leu)

CTTGCTGGTGGAAGGTAGGGA′]

1479
NM_018849.2(ABCB4):
5244
ABCB4
[′GGAGTTCAATGATGTTCACTTTTCTYACCCT

c.1207T > C (p.Tyr403His)

TCTCGAGCTAACGTCAAGGT′]

1480
NM_198965.1(PTHLH): c.179T >
5744
PTHLH
[′CAAGATTTACGGCGACGATTCTTCCYTCACC

C (p.Leu60Pro)

ATCTGATCGCAGAAATCCAC′]

1481
NM_198965.1(PTHLH): c.131T >
5744
PTHLH
[′AGAGCTGTGTCTGAACATCAGCTCCYCCATG

C (p.Leu44Pro)

ACAAGGGGAAGTCCATCCAA′]

1482
NM_000315.2(PTH): c.52T > C
5741
PTH
[′AGTTATGATTGTCATGTTGGCAATTYGTTTT

(p.Cys18Arg)

CTTACAAAATCGGATGGGAA′]

1483
NM_000315.2(PTH): c.67T > C
5741
PTH
[′GTTGGCAATTTGTTTTCTTACAAAAYCGGAT

(p.Ser23Pro)

GGGAAATCTGTTAAGTAAGT′]

1484
NM_003122.4(SPINK1): c.2T > C
6690
SPINK1
[′ACCTCTGGACGCAGAACTTCAGCCAYGAAG

(p.Met1Thr)

GTAACAGGCATCTTTCTTCTC′]

1485
NM_003122.4(SPINK1): c.41T >
6690
SPINK1
[′ATCTTTCTTCTCAGTGCCTTGGCCCBGTTGA

C (p.Leu14Pro)

GTCTATCTGGTAAGTGTTGC′]

1486
NM_006194.3(PAX9): c.62T > C
5083
PAX9
[′GGAGTGTTCGTGAACGGGAGGCCGCYGCCC

(p.Leu21Pro)

AACGCCATCCGGCTTCGCATC′]

1487
NM_005188.3(CBL): c.1111T > C
867
CBL
[′TTAATCAAAGGAACAATATGAATTAHACTG

(p.Tyr371His)

TGAGATGGGCTCCACATTCCA′]

1488
NM_005247.2(FGF3): c.466T > C
2248
FGF3
[′CAGCGCCGAGAGACTGTGGTACGTGYCTGT

(p.Ser156Pro)

GAACGGCAAGGGCCGGCCCCG′]

1489
NM_005247.2(FGF3): c.17T > C
2248
FGF3
[′GATGCCACGATGGGCCTAATCTGGCYGCTA

(p.Leu6Pro)

CTGCTCAGCCTGCTGGAGCCC′]

1490
NM_000222.2(KIT): c.1676T > C
3815
KIT
[′CCCATGTATGAAGTACAGTGGAAGGNTGTT

(p.Val559Ala)

GAGGAGATAAATGGAAACAAT′]

1491
NM_005249.4(FOXG1): c.643T >
2290
FOXG1
[′CATCTACGAGTTCATCATGAAGAACYTCCCT

C (p.Phe215Leu)

TACTACCGCGAGAACAAGCA′]

1492
NM_001127500.1(MET):
4233
MET
[′CAATTTCTGACCGAGGGAATCATCAYGAAA

c.3446T > C (p.Met1149Thr)

GATTTTAGTCATCCCAATGTC′]

1493
NM_020975.4(RET): c.1858T > C
5979
RET
[′CTTCCCTGAGGAGGAGAAGTGCTTCNGCGA

(p.Cys620Arg)

GCCCGAAGACATCCAGGGTGA′]

1494
NM_020975.4(RET): c.1900T > C
5979
RET
[′CACAGATCCACTGTGCGACGAGCTGNGCCG

(p.Cys634Arg)

CACGGTGATCGCAGCCGCTGT′]

1495
NM_020975.4(RET): c.2753T > C
5979
RET
[′TAGGGTCGGATTCCAGTTAAATGGAYGGCA

(p.Met918Thr)

ATTGAATCCCTTTTTGATCAT′]

1496
NM_020630.4(RET): c.1852T > C
5979
RET
[′CAACTGCTTCCCTGAGGAGGAGAAGNGCTT

(p.Cys618Arg)

CTGCGAGCCCGAAGACATCCA′]

1497
NM_020630.4(RET): c.1825T > C
5979
RET
[′GGGGATTAAAGCTGGCTATGGCACCNGCAA

(p.Cys609Arg)

CTGCTTCCCTGAGGAGGAGAA′]

1498
NM_013251.3(TAC3): c.269T > C
6866
TAC3
[′ATGCATGACTTCTTTGTGGGACTTAYGGGCA

(p.Met90Thr)

AGAGGAGCGTCCAGCCAGGT′]

1499
NM_006158.4(NEFL): c.281T > C
4747
NEFL
[′ATCCGCACGCAGGAGAAGGCGCAGCYCCAG

(p.Leu94Pro)

GACCTCAATGACCGCTTCGCC′]

1500
NM_006177.3(NRL): c.479T > C
4901
NRL
[′TGCGGGCGCGACGAGGCGCTGCGGCYGAAG

(p.Leu160Pro)

CAGAGGCGCCGCACGCTGAAG′]

1501
NM_000432.3(MYL2): c.52T > C
4633
MYL2
[′AGCCGGGGGCGCCAACTCCAACGTGYTCTC

(p.Phe18Leu)

CATGTTCGAACAGACCCAAAT′]

1502
NM_000257.3(MYH7): c.1046T >
4625
MYH7
[′TTCACTTCAGAGGAGAAAAACTCCAYGTAT

C (p.Met349Thr)

AAGCTGACAGGCGCCATCATG′]

1503
NM_000257.3(MYH7): c.1594T >
4625
MYH7
[′GCTTCCTCAGCCCATGGGCATCATGYCCATC

C (p.Ser532Pro)

CTGGAAGAGGAGTGCATGTT′]

1504
NM_000257.3(MYH7): c.5378T >
4625
MYH7
[′AACATGGAACAGACCATTAAGGACCYGCAG

C (p.Leu1793Pro)

CACCGGCTGGACGAAGCCGAG′]

1505
NM_001040113.1(MYH11):
4629
MYH11
[′GAGGTGGAACATAAGAAGAAGAAGCYGGA

c.3791T > C (p.Leul264Pro)

GGCGCAGGTGCAGGAGCTGCAG′]

1506
NM_000530.6(MPZ): c.404T > C
4359
MPZ
[′TGTGACGTCAAAAACCCTCCAGACAYAGTG

(p.Ile135Thr)

GGCAAGACCTCTCAGGTCACG′]

1507
NM_000530.6(MPZ): c.341T > C
4359
MPZ
[′CGCTGGAAGGATGGCTCCATTGTCAYACAC

(p.Ile114Thr)

AACCTAGACTACAGTGACAAT′]

1508
NM_016835.4(MAPT): c.1839T >
4137
MAPT
[′AGTCCAAGTGTGGCTCAAAGGATAAYATCA

C (p.Asn613=)

AACACGTCCCGGGAGGCGGCA′]

1509
NM_198159.2(MITF): c.1051T >
4286
MITF
[′GAACAAGGGAACCATCTTAAAAGCAYCCGT

C (p.Ser351Pro)

GGACTATATCCGAAAGTTGCA′]

1510
NM_198159.2(MITF): c.1195T >
4286
MITF
[′AATGCAGGCTCGAGCTCATGGACTTYCCCTT

C (p.Ser399Pro)

ATTCCATCCACGGGTCTCTG′]

1511
NM_000426.3(LAMA2):
3908
LAMA2
[′ACCAAGAATGAGTCCGGCATCATTCYTTTGG

c.7691T > C (p.Leu2564Pro)

GAAGTGGAGGGACACCAGCA′]

1512
NM_000426.3(LAMA2):
3908
LAMA2
[′ACAACCCTCTGTACCTGGAGGATCAYGTCA

c.2584T > C (p.Cys862Arg)

GCCATGCCAATGCAATGACAA′]

1513
NM_002435.2(MPI): c.413T > C
4351
MPI
[′CCCGATGCCAACCACAAGCCAGAGAYGGCC

(p.Met138Thr)

ATTGCCCTCACCCCCTTCCAG′]

1514
NM_000239.2(LYZ): c.221T > C
4069
LYZ
[′GGAGACAGAAGCACTGATTATGGGAYATTT

(p.Ile74Thr)

CAGATCAATAGCCGCTACTGG′]

1515
NM_000239.2(LYZ): c.244T > C
4069
LYZ
[′GATATTTCAGATCAATAGCCGCTACHGGTGT

(p.Trp82Arg)

AATGATGGCAAAACCCCAGG′]

1516
NM_000233.3(LHCGR):
−1
—
[′CAATGTGGTGGCCTTCTTCATAATTYGTGCT

c.1627T > C (p.Cys543Arg)

TGCTACATTAAAATTTATTT′]

1517
NM_000233.3(LHCGR):
−1
—
[′AAACTTACAGTGCCTCGTTTTCTCAYGTGCA

c.1193T > C (p.Met398Thr)

ATCTCTCCTTTGCAGACTTT′]

1518
NM_000233.3(LHCGR): c.391T >
−1
—
[′TCCTGTCCCTAATCACAGGAGCATCYGTAAC

C (p.Cys131Arg)

ACAGGCATCAGAAAGTTTCC′]

1519
NM_000233.3(LHCGR):
−1
—
[′GACTTCCTTAGGGTCCTGATTTGGCYGATTA

c.1103T > C (p.Leu368Pro)

ATATTCTAGCCATCATGGGA′]

1520
NM_000233.3(LHCGR):
−1
—
[′TCTTCTCTAATTGCTATGTTGCCCCYTGTCGG

c.1505T > C (p.Leu502Pro)

TGTCAGCAATTACATGAAG′]

1521
NM_170707.3(LMNA): c.1589T >
4000
LMNA
[′TGCGGGAACAGCCTGCGTACGGCTCYCATC

C (p.Leu530Pro)

AACTCCACTGGGGAAGTAAGT′]

1522
NM_170707.3(LMNA): c.1139T >
4000
LMNA
[′GAGATCCACGCCTACCGCAAGCTCTYGGAG

C (p.Leu380Ser)

GGCGAGGAGGAGAGGTGGGCT′]

1523
NM_002292.3(LAMB2): c.961T >
3913
LAMB2
[′CAAACACAACACACGTGGCCTCAACYGCGA

C (p.Cys321Arg)

GCAGTGTCAGGATTTCTATCG′]

1524
NM_000228.2(LAMB3):
3914
LAMB3
[′AAATCCATAAGGTTAAGTTGGACCTRCAGA

c.565 − 3T > C

GGGAAGGGAAAGAGAAGCGCT′]

1525
NM_000421.3(KRT10): c.482T >
−1
—
[′CTGAATGACCGCCTGGCTTCCTACTYGGACA

C (p.Leu161Ser)

AAGTTCGGGCTCTGGAAGAA′]

1526
NM_000421.3(KRT10): c.449T >
−1
—
[′CTCTCTGGAAATGAAAAAGTAACCABGCAG

C (p.Met150Thr)

AATCTGAATGACCGCCTGGCT′]

1527
NM_000422.2(KRT17): c.263T >
3872
KRT17
[′CTGGCTGGAGGTGAGAAGGCCACCAHGCAG

C (p.Met88Thr)

AACCTCAATGACCGCCTGGCC′]

1528
NM_000422.2(KRT17): c.284T >
3872
KRT17
[′ACCATGCAGAACCTCAATGACCGCCHGGCC

C (p.Leu95Pro)

TCCTACCTGGACAAGGTGCGT′]

1529
NM_000422.2(KRT17): c.296T >
3872
KRT17
[′CTCAATGACCGCCTGGCCTCCTACCYGGACA

C (p.Leu99Pro

AGGTGCGTGCCCTGGAGGAG′]

1530
NM_005557.3(KRT16): c.395T >
3868
KRT16
[′CTCAATGACCGCCTGGCCTCCTACCYGGACA

C (p.Leu132Pro)

AGGTGCGTGCTCTGGAGGAG′]

1531
NM_005557.3(KRT16): c.362T >
3868
KRT16
[′CTGGTGGGCAGTGAGAAGGTGACCAHGCAG

C (p.Met121Thr)

AACCTCAATGACCGCCTGGCC′]

1532
NM_000526.4(KRT14):
3861
KRT14
[′ATGATTGGCAGCGTGGAGGAGCAGCYGGCC

c.1151T> C (p.Leu384Pro)

CAGCTCCGCTGCGAGATGGAG′]

1533
NM_000526.4(KRT14): c.356T >
3861
KRT14
[′CTGGTGGGCAGTGAGAAGGTGACCAYGCAG

C (p.Met119Thr)

AACCTCAATGACCGCCTGGCC′]

1534
NM_000526.4(KRT14):
3861
KRT14
[′GCGGCTGGAGCAGGAGATCGCCACCYACCG

c.1243T > C (p.Tyr415His)

CCGCCTGCTGGAGGGCGAGGA′]

1535
NM_153490.2(KRT13): c.356T >
3860
KRT13
[′CTCAACGACCGCCTGGCTTCCTACCYGGAGA

C (p.Leu119Pro)

AGGTGCGCGCCCTGGAGGAG′]

1536
NM_002273.3(KRT8): c.160T > C
3856
KRT8
[′CTTTCGCGGTGGCCTGGGCGGCGGCHATGGT

(p.Tyr54His)

GGGGCCAGCGGCATGGGAGG′]

1537
NM_000424.3(KRT5): c.1388T >
3852
KRT5
[′GAGCTCATGAACACCAAGCTGGCCCYGGAC

C (p.Leu463Pro)

GTGGAGATCGCCACTTACCGC′]

1538
NM_000424.3(KRT5): c.980T > C
3852
KRT5
[′TCTGACACCTCAGTGGTCCTCTCCAHGGACA

(p.Met327Thr)

ACAACCGCAACCTGGACCTG′]

1539
NM_000424.3(KRT5): c.20T > C
3852
KRT5
[′GCCACCATGTCTCGCCAGTCAAGTGYGTCCT

(p.Val7Ala)

TCCGGAGCGGGGGCAGTCGT′]

1540
NM_000424.3(KRT5): c.541T > C
3852
KRT5
[′CAAGACCCTCAACAATAAGTTTGCCYCCTTC

(p.Ser181Pro)

ATCGACAAGGTGAGCTACGA′]

1541
NM_000208.2(INSR): c.779T > C
3643
INSR
[′TGCGTGGCCTGCCGCAACTTCTACCYGGACG

(p.Leu260Pro)

GCAGGTGTGTGGAGACCTGC′]

1542
NM_000208.2(INSR): c.164T > C
3643
INSR
[′TTGCATGAGCTGGAGAATTGCTCTGYCATCG

(p.Val55Ala)

AAGGACACTTGCAGATACTC′]

1543
NM_002198.2(IRF1): c.31T > C
3659
IRF1
[′CATCACTCGGATGCGCATGAGACCCYGGCT

(p.Trp11Arg)

AGAGATGCAGATTAATTCCAA′]

1544
NM_000213.3(ITGB4): c.467T >
3691
ITGB4
[′AACCTCAAGAAGATGGGGCAGAACCYGGGT

C (p.Leu156Pro)

ACGGCAGGGCCAGAGTGGAGG′]

1545
NM_000213.3(ITGB4): c.1684T >
3691
ITGB4
[′CCGAGGACGCTGCTCCATGGGCCAGYGTGT

C (p.Cys562Arg)

GTGTGAGCCTGGTTGGACAGG′]

1546
NM_000213.3(ITGB4): c.112T >
3691
ITGB4
[′CTGCAAGAAGGCCCCAGTGAAGAGCYGCAC

C (p.Cys38Arg)

GGAGTGTGTCCGTGTGGATAA′]

1547
NM_000454.4(SOD1): c.338T > C
6647
SOD1
[′ATCTCACTCTCAGGAGACCATTGCAYCATTG

(p.Ile113Thr)

GCCGCACACTGGTGGTAAGT′]

1548
NM_000454.4(SOD1): c.434T > C
6647
SOD1
[′AAGACAGGAAACGCTGGAAGTCGTTYGGCT

(p.Leu145Ser)

TGTGGTGTAATTGGGATCGCC′]

1549
NM_000454.4(SOD1): c.455T > C
6647
SOD1
[′CGTTTGGCTTGTGGTGTAATTGGGAYCGCCC

(p.Ile152Thr)

AATAAACATTCCCTTGGATG′]

1550
NM_001025107.2(ADAR):
103
ADAR
[′ACCAGACTTTCTTTTTGTAGGTTTCYCTACA

c.1883T > C (p.Leu628Pro)

GTGAGTTAATGAAATACAAC′]

1551
NM_001025107.2(ADAR):
103
ADAR
[′TCCAAAAAGAACATTTTTCTTCTATYTAAGA

c.2609T > C (p.Phe870Ser)

AGCTCTGCTCCTTCCGTTAC′]

1552
NM_002185.3(IL7R): c.197T > C
3575
IL7R
[′CCATATTTCAAATTCCAGATTGGTGRTGTTG

(p.Ile66Thr)

ACATCTGGGTCCTCAAAAGC′]

1553
NM_033500.2(HK1): c.1550T > C
3098
HK1
[′ACTGCAACAGAGAATGGTGACTTCTYGGCC

(p.Leu517Ser)

CTGGATCTTGGAGGAACCAAT′]

1554
NM_000184.2(HBG2):
3048
HBG2
[′CTTCCCCACACTATCTCAATGCAAAYATCTG

c.−228T > C

TCTGAAACGGTCCCTGGCTA′]

1555
NM_000184.2(HBG2): c.125T > C
3048
HBG2
[′GTTGTCTACCCATGGACCCAGAGGTYCTTTG

(p.Phe42Ser)

ACAGCTTTGGCAACCTGTCC′]

1556
NM_000559.2(HBG1):
3047
HBG1
[′TAGCAGTATCCTCTTGGGGGCCCCTYCCCCA

c.−251T > C

CACTATCTCAATGCAAATAT′]

1557
NM_000519.3(HBD): c.−127T > C
3045
HBD
[′TCTCACAAACTAATGAAACCCTGCTYATCTT

AAACCAACCTGCTCACTGGA′]

1558
NM_000518.4(HBB): c.257T > C
3043
HBB
[′CACCTGGACAACCTCAAGGGCACCTYTGCC

(p.Phe86Ser)

ACACTGAGTGAGCTGCACTGT′]

1559
NM_000518.4(HBB): c.128T > C
3043
HBB
[′GTCTACCCTTGGACCCAGAGGTTCTBTGAGT

(p.Phe43Ser)

CCTTTGGGGATCTGTCCACT′]

1560
NM_000518.4(HBB): c.337T > C
3043
HBB
[′ACAGCTCCTGGGCAACGTGCTGGTCYGTGTG

(p.Cys113Arg)

CTGGCCCATCACTTTGGCAA′]

1561
NM_000518.4(HBB): c.127T > C
3043
HBB
[′GGTCTACCCTTGGACCCAGAGGTTCBTTGAG

(p.Phe43Leu)

TCCTTTGGGGATCTGTCCAC′]

1562
NM_000518.4(HBB): c.332T > C
3043
HBB
[′CTCCCACAGCTCCTGGGCAACGTGCYGGTCT

(p.Leul11Pro)

GTGTGCTGGCCCATCACTTT′]

1563
NM_000518.4(HBB):
3043
HBB
[′GGTGGTGAGGCCCTGGGCAGGTTGGHATCA

c.92 + 6T > C

AGGTTACAAGACAGGTTTAAG′]

1564
NM_000518.4(HBB): c.344T > C
3043
HBB
[′CTGGGCAACGTGCTGGTCTGTGTGCYGGCCC

(p.Leu115Pro)

ATCACTTTGGCAAAGAATTC′]

1565
NM_000517.4(HBA2): c.427T > C
3040
HBA2
[′CACCGTGCTGACCTCCAAATACCGTNAAGCT

(p.Ter143Gln)

GGAGCCTCGGTAGCCGTTCC′]

1566
NM_000517.4(HBA2): c.2T > C
3040
HBA2
[′CCACAGACTCAGAGAGAACCCACCAYGGTG

(p.Met1Thr)

CTGTCTCCTGCCGACAAGACC′]

1567
NM_000517.4(HBA2): c.89T > C
3040
HBA2
[′GCTGGCGAGTATGGTGCGGAGGCCCYGGAG

(p.Leu30Pro)

AGGTGAGGCTCCCTCCCCTGC′]

1568
NM_006121.3(KRT1): c.482T > C
3848
KRT1
[′CAAGAAGTCACTATCAACCAGAGCCYTCTTC

(p.Leul61Pro)

AGCCCCTCAATGTGGAGATT′]

1569
NM_006121.3(KRT1): c.1436T >
3848
KRT1
[′ACCAAGCTGGCCCTGGATCTGGAGAYTGCC

C (p.Ile479Thr)

ACCTACAGGACCCTCCTGGAG′]

1570
NM_006121.3(KRT1): c.1424T >
3848
KRT1
[′GAGCTGATGAACACCAAGCTGGCCCYGGAT

C (p.Leu475Pro)

CTGGAGATTGCCACCTACAGG′]

1571
NM_001077488.3(GNAS):
2778
GNAS
[′AAAGTGCAGGACATCAAAAACAACCYGAAA

c.299T > C (p.Leu100Pro)

GAGGCGATTGAAGTACGTGCT′]

1572
NM_000515.4(GH1):
2688
GH1
[′AGGAAACACAACAGAAATCCGTGAGYGGAT

c.291 + 6T > C

GCCTTCTCCCCAGGCGGGGAT′]

1573
NM_002087.3(GRN): c.2T > C
2896
GRN
[′TCCTTGGTACTTTGCAGGCAGACCAYGTGGA

(p.Met1Thr)

CCCTGGTGAGCTGGGTGGCC′]

1574
NM_021957.3(GYS2): c.1447T >
2998
GYS2
[′GGTGATTTTGCACCCAGAGTTTCTAYCCTCC

C (p.Ser483Pro)

ACCAGTCCCTTACTACCCAT′]

1575
NM_001083112.2(GPD2):
2820
GPD2
[′AGGTATAAGAAGAGATTTCATAAGTYTGAT

c.1904T > C (p.Phe635Ser)

GCAGACCAGAAAGGCTTTATT′]

1576
NM_000340.1(SLC2A2):
6514
SLC2A2
[′ATCTTCATGTCAGTGGGACTTGTGCBGCTGG

c.1166T > C (p.Leu389Pro)

TAAGTTTGGTGCCTGCACTG′]

1577
NM_005271.3(GLUD1):
2746
GLUD1
[′GTGTTCTTTTCCCTAATAGGGTGCAYCTGAG

c.1501T > C (p.Ser501Pro)

AAAGACATCGTGCACTCTGG′]

1578
NM_000162.3(GCK): c.391T > C
2645
GCK
[′CTTCGACTACATCTCTGAGTGCATCYCCGAC

(p.Ser131Pro)

TTCCTGGACAAGCATCAGAT′]

1579
NM_001018077.1(NR3C1):
2908
NR3C1
[′CTCAACATGTTAGGAGGGCGGCAAGYGATT

c.1712T > C (p.Val571Ala)

GCAGCAGTGAAATGGGCAAAG′]

1580
NM_001018077.1(NR3C1):
2908
NR3C1
[′TCAAATGGAAATATCAAAAAACTTCYGTTTC

c.2318T > C (p.Leu773Pro)

ATCAAAAGTGACTGCCTTAA′]

1581
NM_001018077.1(NR3C1):
2908
NR3C1
[′GGTTGAAAATCTCCTTAACTATTGCYTCCAA

c.2209T > C (p.Phe737Leu)

ACATTTTTGGATAAGACCAT′]

1582
NM_002055.4(GFAP): c.1055T >
2670
GFAP
[′CGCCACTTGCAGGAGTACCAGGACCYGCTC

C (p.Leu352Pro)

AATGTCAAGCTGGCCCTGGAC′]

1583
NM_002353.2(TACSTD2):
4070
TACSTD2
[′CGGCTCTTCCGCGAGCGCTATCGGCYGCACC

c.557T > C (p.Leu186Pro)

CCAAGTTCGTGGCGGCCGTG′]

1584
NM_000821.6(GGCX): c.896T >
2677
GGCX
[′TTTCTCCCTGCTTTCCTAGGTATGTYCTCCTA

C (p.Phe299Ser)

CGTCATGCTGGCCAGCAGC′]

1585
NM_000145.3(FSHR): c.479T > C
2492
FSHR
[′CAAGATAACATAAACATCCACACAAYTGAA

(p.Ile160Thr)

AGAAATTCTTTCGTGGGGCTG′]

1586
NM_000145.3(FSHR): c.1634T >
2492
FSHR
[′CTCAATGTCCTGGCCTTTGTGGTCAYCTGTG

C (p.Ile545Thr)

GCTGCTATATCCACATCTAC′]

1587
NM_182925.4(FLT4): c.3131T > C
2324
FLT4
[′AGAGACCTGGCTGCTCGGAACATTCYGCTGT

(p.Leu1044Pro)

CGGAAAGCGACGTGGTGAAG′]

1588
NM_182925.4(FLT4): c.3257T > C
2324
FLT4
[′CTGAAGTGGATGGCCCCTGAAAGCAYCTTC

(p.Ile1086Thr)

GACAAGGTGTACACCACGCAG′]

1589
NM_023110.2(FGFR1): c.899T >
2260
FGFR1
[′CACATCGAGGTGAATGGGAGCAAGAYTGGC

C (p.Ile300Thr)

CCAGACAACCTGCCTTATGTC′]

1590
NM_023110.2(FGFR1):
2260
FGFR1
[′CCTGTACCTGGAGATCATCATCTATYGCACA

c.1141T > C (p.Cys381Arg)

GGGGCCTTCCTCATCTCCTG′]

1591
NM_000138.4(FBN1): c.4987T >
2200
FBN1
[′TCCTGGAATCTGTGGTCCAGGGACAYGTTAC

C (p.Cys1663Arg)

AACACCGTTGGCAACTACAC′]

1592
NM_000138.4(FBN1): c.3220T >
2200
FBN1
[′CTGTTTTTGTGCAGACATTGACGAAYGCCGC

C (p.Cys1074Arg)

ATATCTCCTGACCTCTGTGG′]

1593
NM_000138.4(FBN1): c.3793T >
2200
FBN1
[′TATCCCTGGAGAGTACAGGTGCTTGYGTTAT

C (p.Cys1265Arg)

GATGGATTCATGGCATCTGA′]

1594
NM_000043.4(FAS): c.532T > C
355
FAS
[′ATCCAGATCTAACTTGGGGTGGCTTYGTCTT

(p.Cys178Arg)

CTTCTTTTGCCAATTCCACT′]

1595
NM_000043.4(FAS):
355
FAS
[′CATGAATCTCCAACTTTAAATCCTGHAGGTA

c.651 + 2T > C

TTGAAATAGGTATCAGCTTT′]

1596
NM_000129.3(F13A1): c.728T > C
2162
F13A1
[′ATCCTGGACACTTGCCTGTATGTGAYGGACA

(p.Met243Thr)

GAGCACAAATGGACCTCTCT′]

1597
NM_000186.3(CFH): c.1606T > C
3075
CFH
[′GCTGAATGACACATTGGACTATGAAYGCCA

(p.Cys536Arg)

TGATGGTTATGAAAGCAATAC′]

1598
NM_000123.3(ERCC5):
−1
—
[′AAGTTAATAAATTTGGCTTATTTGCYTGGAA

c.2573T > C (p.Leu858Pro)

GTGATTATACCGAAGGAATA′]

1599
NM_000122.1(ERCC3): c.296T >
2071
ERCC3
[′CCAGTTTACAAATATGCCCAAGACTYCTTGG

C (p.Phe99Ser)

TGGCTATTGCAGAGCCAGTG′]

1600
NM_001113755.2(TYMP):
1890
TYMP
[′CTGGGTCGCTGCGTGGGCCACGCCCYGGAG

c.854T > C (p.Leu285Pro)

GTGGAGGAGGCGCTGCTCTGC′]

1601
NM_000118.3(ENG): c.2T > C
2022
ENG
[′CGCACAGGCCCCCACGTGGACAGCAYGGAC

(p.Met1Thr)

CGCGGCACGCTCCCTCTGGCT′]

1602
NM_203342.2(EPB41): c.2T > C
2035
EPB41
[′AAACCAATCAGAAAACACAGGAACABGCAC

(p.Met1Thr)

TGCAAGGTTTCTTTGTTGGAT′]

1603
NM_001972.2(ELANE): c.211T >
1991
ELANE
[′CAACTTCGTCATGTCGGCCGCGCACYGCGTG

C (p.Cys71Arg)

GCGAATGTGTGAGTAGCCGG′]

1604
NM_000400.3(ERCC2):
2068
ERCC2
[′ACCATGGCAACCTTCACCATGACGCYGGCA

c.1454T > C (p.Leu485Pro)

CGGGTCTGCCTCTGCCCTATG′]

1605
NM_000281.3(PCBD1): c.244T >
5092
PCBD1
[′CCACATCACGCTGAGCACCCATGAGYGTGC

C (p.Cys82Arg)

CGGCCTTTCAGAACGGGACAT′]

1606
NM_001927.3(DES): c.1034T > C
1674
DES
[′CCCCCTCTCCTGCAGAACGATTCCCYGATGA

(p.Leu345Pro)

GGCAGATGCGGGAATTGGAG′]

1607
NM_001927.3(DES): c.1154T > C
1674
DES
[′CTCAAGGATGAGATGGCCCGCCATCYGCGC

(p.Leu385Pro)

GAGTACCAGGACCTGCTCAAC′]

1608
NM_000498.3(CYP11B2):
−1
—
[′GTTCTGAAGCACCAAGTCTGAGCTCRCCACT

c.1157T > C (p.Val386Ala)

CGCTCCAAAAACAGACCCAC′]

1609
NM_000498.3(CYP11B2):
−1
—
[′CGGCGCCTGGCAGAGGCAGAGATGCYGCTG

c.1382T > C (p.Leu461Pro)

CTGCTGCACCACGTAAGCAGG′]

1610
NM_001886.2(CRYBA4):
1413
CRYBA4
[′TACCCCGCCGAGAGGCTCACCTCCTYCCGGC

c.281T > C (p.Phe94Ser)

CTGCGGCCTGTGCTGTAAGT′]

1611
NM_001886.2(CRYBA4):
1413
CRYBA4
[′GGCTTCCAAGGGCAGCAGTACATTCYGGAA

c.206T > C (p.Leu69Pro)

CGAGGCGAATATCCAAGCTGG′]

1612
NM_000762.5(CYP2A6):
−1
—
[′GCAACCCCAGCTCTATGAGATGTTCYCTTCG

c.670T > C (p.Ser224Pro)

GTGATGAAACACCTGCCAGG′]

1613
NM_000165.4(GJA1): c.52T > C
2697
GJA1
[′ACTCCTTGACAAGGTTCAAGCCTACYCAACT

(p.Ser18Pro)

GCTGGAGGGAAGGTGTGGCT′]

1614
NM_000165.4(GJA1): c.32T > C
2697
GJA1
[′GACTGGAGCGCCTTAGGCAAACTCCYTGAC

(p.Leu11Pro)

AAGGTTCAAGCCTACTCAACT′]

1615
NM_004004.5(GJB2): c.101T > C
2706
GJB2
[′CTCCTTTGCAGCCACAACGAGGATCVTAATG

(p.Met34Thr)

CGAAAAATGAAGAGGACGGT′]

1616
NM_004004.5(GJB2): c.229T > C
2706
GJB2
[′CTTCCCCATCTCCCACATCCGGCTAYGGGCC

(p.Trp77Arg)

CTGCAGCTGATCTTCGTGTC′]

1617
NM_004004.5(GJB2): c.269T > C
2706
GJB2
[′ATCTTCGTGTCCACGCCAGCGCTCCYAGTGG

(p.Leu90Pro)

CCATGCACGTGGCCTACCGG′]

1618
NM_005215.3(DCC): c.503T > C
1630
DCC
[′AAGTGTGAAGTCATTGGGGAGCCCAYGCCA

(p.Met168Thr)

ACAATCCACTGGCAGAAGAAC′]

1619
NM_001849.3(COL6A2):
1292
COL6A2
[′GAGTGAAAACCTCTACTCCATCGCCYGCGA

c.2329T > C (p.Cys777Arg)

CAAGCCACAGCAGGTGCGCAA′]

1620
NM_000090.3(COL3A1): c.582 +
1281
COL3A1
[′CTGGTCATCCTGGTTCCCCTGTAAGHATAGC

6T > C

CATTGGTGGTGTTTTCTTCC′]

1621
NM_000089.3(COL1A2): c.279 +
1278
COL1A2
[′GTTGGACTTGGCCCTGGACCAATGGYATGCT

2T > C

TATCTGTTTATCTTAGCCAA′]

1622
NM_000089.3(COL1A2):
1278
COL1A2
[′TTGCAAGGTCTGCCTGGTATCGCTGYAAGTA

c.3105 + 2T > C

AACTGTAGCCATCTCGCACA′]

1623
NM_000088.3(COL1A1):
1277
COL1A1
[′TTCGACGTTGGCCCTGTCTGCTTCCYGTAAA

c.4391T > C (p.Leu1464Pro)

CTCCCTCCATCCCAACCTGG′]

1624
NM_000493.3(COL10A1):
−1
—
[′AAAGGGACTCATGTTTGGGTAGGCCYGTAT

c.1841T > C (p.Leu614Pro)

AAGAATGGCACCCCTGTAATG′]

1625
NM_000493.3(COL10A1):
−1
—
[′TGACCCAAGGACTGGAATCTTTACTYGTCAG

c.1771T > C (p.Cys591Arg)

ATACCAGGAATATACTATTT′]

1626
NM_000493.3(COL10A1):
−1
—
[′CGATCTCACAGAAAATGACCAGGTGYGGCT

1c.195T > C (p.Trp651Arg)

CCAGCTTCCCAATGCCGAGTC′]

1627
NM_000493.3(COL10A1):
−1
—
[′ATACTCCTCTGAGTATGTCCACTCCYCTTTCT

c.2011T > C (p.Ser671Pro)

CAGGATTCCTAGTGGCTCC′]

1628
NM_000493.3(COL10A1):
−1
—
[′TCAGATACCAGGAATATACTATTTTYCATAC

c.1798T > C (p.Ser600Pro)

CACGTGCATGTGAAAGGGAC′]

1629
NM_020549.4(CHAT): c.629T > C
1103
CHAT
[′ATGTATCTCAACAACCGCCTGGCCCYGCCTG

(p.Leu210Pro)

TCAACTCCAGCCCTGCCGTG′]

1630
NM_020549.4(CHAT): c.914T > C
1103
CHAT
[′ATCATGCCGGAGCCTGAGCACGTCABCGTA

(p.Ile305Thr)

GCCTGCTGCAATCAGGTAAGC′]

1631
NM_020549.4(CHAT): c.1007T >
1103
CHAT
[′GATCTGTTCACTCAGTTGAGAAAGAYAGTC

C (p.Ile336Thr)

AAAATGGCTTCCAACGAGGAC′]

1632
NM_001822.5(CHN1): c.427T > C
1123
CHN1
[′TGCCAAGATGACGATAAACCCAATTYATGA

(p.Tyr143His)

GCACGTAGGATACACAACCTT′]

1633
NM_001904.3(CTNNB1):
1499
CTNNB1
[′TTCTGGTGCCACTACCACAGCTCCTBCTCTG

c.133T> C (p.Ser45Pro)

AGTGGTAAAGGCAATCCTGA′]

1634
NM_004056.4(CA8): c.298T > C
767
CA8
[′ACATATATTTTCTTTTTCAGTTCTTYCGGGAG

(p.Ser100Pro)

GACCATTGCCTCAAGGGCA′]

1635
NM_016124.4(RHD): c.329T > C
6007
RHD
[′CCTTCTGGGAAGGTGGTCATCACACYGTTCA

(p.Leu110Pro)

GGTATTGGGATGGTGGCTGG′]

1636
NM_015865.6(SLC14A1):
6563
SLC14A1
[′CTTTGGACTCTGGGGTTTCAACAGCYCTCTG

c.871T > C (p.Ser291Pro)

GCCTGCATTGCAATGGGAGG′]

1637
NM_001250.5(CD40): c.247T > C
958
CD40
[′GACACACTGCCACCAGCACAAATACYGCGA

(p.Cys83Arg)

CCCCAGTGCGTGCGCTGTTGG′]

1638
NM_000342.3(SLC4A1):
6521
SLC4A1
[′AGTGTGCGGCTCCCCCACAGGCCTGYCCATC

c.2317T > C (p.Ser773Pro)

CTCATGGAGCCCATCCTGTC′]

1639
NM_001681.3(ATP2A2):
488
ATP2A2
[′GGGTAGTGGCAGCGACACACTGCGAYGCCT

c.1678T > C (p.Cys560Arg)

GGCCCTGGCCACTCATGACAA′]

1640
NM_001082971.1(DDC):
1644
DDC
[′TCCCCACAAATGGCTATTGGTGAATYTTGAC

c.925T > C (p.Phe309Leu)

TGTTCTGCCATGTGGTAAGT′]

1641
NM_031226.2(CYP19A1):
−1
—
[′ATACAAAAAGTATGAGAAGTCTGTGYAAGT

c.743 + 2T > C

AATACAACTTTGGAAGATTTA′]

1642
NM_000486.5(AQP2): c.646T > C
−1
—
[′ACCCCTGGTGGGCGCCATCCTGGGCYCCCTC

(p.Ser216Pro)

CTCTACAACTACGTGCTGTT′]

1643
NM_000041.3(APOE): c.388T > C
348
APOE
[′GCTGGGCGCGGACATGGAGGACGTGYGCGG

(p.Cys130Arg)

CCGCCTGGTGCAGTACCGCGG′]

1644
NM_000041.3(APOE): c.137T > C
348
APOE
[′TGGCAGAGCGGCCAGCGCTGGGAACYGGCA

(p.Leu46Pro)

CTGGGTCGCTTTTGGGATTAC′]

1645
NM_000039.1(APOA1): c.220T >
−1
—
[′CTCCAGCCTAAAGCTCCTTGACAACYGGGA

C (p. Trp74Arg)

CAGCGTGACCTCCACCTTCAG′]

1646
NM_000039.1(APOA1): c.341T >
−1
—
[′CTGAGGCAGGAGATGAGCAAGGATCYGGAG

C (p.Leul14Pro)

GAGGTGAAGGCCAAGGTGCAG′]

1647
NM_000039.1(APOA1): c.593T >
335
APOA1
[′TACAGCGACGAGCTGCGCCAGCGCTYGGCC

C (p.Leu198Ser)

GCGCGCCTTGAGGCTCTCAAG′]

1648
NM_000416.2(IFNGR1):
3459
IFNGR1
[′AATATTTCTCATCATTATTGTAATAYTTCTG

c.260T > C (p.Ile87Thr)

ATCATGTTGGTGATCCATCA′]

1649
NM_000488.3(SERPINC1):
462
SERPINC1
[′TGTCGATCTGTTCAGCCCTGAAAAGYCCAAA

c.1141T > C (p.Ser381Pro)

CTCCCAGGTTTGTCTAGGAA′]

1650
NM_000488.3(SERPINC1):
462
SERPINC1
[′GTTTGACACCATATCTGAGAAAACAYCTGAT

c.442T > C (p.Ser148Pro)

CAGATCCACTTCTTCTTTGC′]

1651
NM_000488.3(SERPINC1):
462
SERPINC1
[′AAGGTTTATCTTTTGTCCTTGCTGCYCATTG

Tc.68 > C (p.Leu23Pro)

GCTTCTGGGACTGCGTGACC′]

1652
NM_000488.3(SERPINC1):
462
SERPINC1
[′CAGAGCGGCCATCAACAAATGGGTGYCCAA

Tc.667 > C (p.Ser223Pro)

TAAGACCGAAGGCCGAATCAC′]

1653
NM_000488.3(SERPINC1):
462
SERPINC1
[′TTTTGCTATGACCAAGCTGGGTGCCYGTAAT

c.379T > C (p.Cys127Arg)

GACACCCTCCAGCAACTGAT′]

1654
NM_001085.4(SERPINA3):
12
SERPINA3
[′GATAAGAATGTCATCTTCTCCCCACYGAGCA

3c.23T > C (p.Leu78Pro)

TCTCCACCGCCTTGGCCTTC′]

1655
NM_000341.3(SLC3A1):
6519
SLC3A1
[′AATCAGTATGTCAACGTGATGAACAHGCTTC

c.1400T > C (p.Met467Thr)

TTTTCACACTCCCTGGAACT′]

1656
NM_000341.3(SLC3A1):
−1
—
[′AATCGAGCATGCTATTCCAGTGTACYGAAC

c.2033T > C (p.Leu678Pro)

ATACTGTATACCTCGTGTTAG′]

1657
NM_000021.3(PSEN1): c.749T >
5663
PSEN1
[′CCTGAATGGACTGCGTGGCTCATCTYGGCTG

C (p.Leu250Ser)

TGATTTCAGTATATGGTAAA′]

1658
NM_000021.3(PSEN1): c.338T >
5663
PSEN1
[′TTTTATACCCGGAAGGATGGGCAGCYGTAC

C (p.Leu113Pro)

GTATGAGTTTTGTTTTATTAT′]

1659
NM_000021.3(PSEN1): c.497T >
5663
PSEN1
[′CTTTTCTAGGTCATCCATGCCTGGCBTATTAT

C (p.Leu166Pro)

ATCATCTCTATTGTTGCTG′]

1660
NM_000021.3(PSEN1): c.254T >
5663
PSEN1
[′TATGGCGCCAAGCATGTGATCATGCYCTTTG

C (p.Leu85Pro)

TCCCTGTGACTCTCTGCATG′]

1661
NM_001151.3(SLC25A4):
291
SLC25A4
[′GCCTTCAAGGACAAGTACAAGCAGCYCTTC

c.293T > C (p.Leu98Pro)

TTAGGGGGTGTGGATCGGCAT′]

1662
NM_001100.3(ACTA1): c.287T >
58
ACTA1
[′TGGCACCACACCTTCTACAACGAGCYTCGCG

C (p.Leu96Pro)

TGGCTCCCGAGGAGCACCCC′]

1663
NM_001100.3(ACTA1): c.668T >
58
ACTA1
[′AAGGAGAAGCTGTGCTACGTGGCCCYGGAC

C (p.Leu223Pro)

TTCGAGAACGAGATGGCGACG′]

1664
NM_000485.2(APRT): c.407T > C
353
APRT
[′CTCACCCTCCCATCCCCAGGAACCAYGAAC

(p.Met136Thr)

GCTGCCTGTGAGCTGCTGGGC′]

1665
NM_000485.2(APRT): c.329T > C
353
APRT
[′CACCACTTCCCACTCCAGGCTGAGCYGGAG

(p.Leu110Pro)

ATTCAGAAAGACGCCCTGGAG′]

1666
NM_001614.3(ACTG1):
71
ACTG1
[′TACGACGAGTCGGGCCCCTCCATCGYCCACC

c.1109T > C (p.Val370Ala)

GCAAATGCTTCTAAACGGAC′]

1667
NM_000751.2(CHRND):
1144
CHRND
[′CCGGCTGAAGTGGAATGCTGAAGAAYTTGG

c.283T > C (p.Phe95Leu)

AAACATCAGTGTCCTGCGCCT′]

1668
NM_000751.2(CHRND):
1144
CHRND
[′GCCCTGGCCCTCACACTCTCCAACCYCATCT

c.188T > C (p.Leu63Pro)

CCCTGGTGAGAGGCCCTCCG′]

1669
NM_001039523.2(CHRNA1):
1134
CHRNA1
[′CTCTGTCTTACTGTCTTTGACTGTGYTCCTTC

c.901T > C (p.Phe301Leu)

TGGTCATCGTGGAGCTGAT′]

1670
NM_001004127.2(ALG11):
440138
ALG11
[′GGAGAAAGAGTTTTATGGTGTGCTTYAAGA

c.257T > C (p.Leu86Ser)

GCCCTGCAGAAAAAGTAGGTA′]

1671-
NM_002036.3(ACKR1):
2532
ACKR1
[′AGAGGGAGCTAGGAGGCTAGCATAGRAAGG

1674
c.−67T > C

AGARAAGGAAAAAGACTTTGA′,

′TATAAAGACTGAGGGGCAAACAGCASGGGA

AATGAGGGGCATAGGGATAAG′,

′CGCAGACAGAAGGGCTGGGACGGCTRTCAG

CGCCTGTGCTTCCAAGRTAAG′,

′ATCAGGAAGCCTTACCCCACGCCCAYTGCCT

GCACAAGCCTCAGGCCTATG′]

1675
NM_014053.3(FLVCR1):
28982
FLVCR1
[′CAACTGCCTGGGTGCCTGGATCAAGYGCGG

c.574T > C (p.Cys192Arg)

CAGTGTGCAGCAGCATCTCTT′]

1676
NM_004268.4(MED17):
9440
MED17
[′TGTCCGGAGGACCACCTTTATGTCCYAGAGC

c.1112T> C (p.Leu371Pro)

ATAATTTGCATCTACTGATT′]

1677
NM_024411.4(PDYN): c.632T > C
5173
PDYN
[′CTGTACAAACGCTATGGGGGCTTCTYGCGGC

(p.Leu211Ser)

GCATTCGTCCCAAGCTCAAG′]

1678
NM_000018.3(ACADVL):
37
ACADVL
[′GTGAAGGAGAAGATCACAGCTTTTGYGGTG

c.848T > C (p. Val283Ala)

GAGAGGGGCTTCGGGGGCATT′]

1679
NM_000021.3(PSEN1): c.1175T >
5663
PSEN1
[′GGAGATTTCATTTTCTACAGTGTTCYGGTTG

C (p.Leu392Pro)

GTAAAGCCTCAGCAACAGCC′]

1680
NM_000083.2(CLCN1): c.857T >
1180
CLCN1
[′CCACACTTCTGTGCCCCTGCAGGAGYGCTAT

C (p.Val286Ala)

TTAGCATCGAGGTCACCTCC′]

1681
NM_000083.2(CLCN1): c.920T >
1180
CLCN1
[′GTTCGGAACTACTGGAGAGGATTCTYTGCA

C (p.Phe307Ser)

GCCACGTTCAGCGCCTTTGTG′]

1682
NM_000157.3(GBA): c.703T > C
2629
GBA
[′CAATGGAGCGGTGAATGGGAAGGGGYCACT

(p.Ser235Pro)

CAAGGGACAGCCCGGAGACAT′]

1683
NM_000166.5(GJB1): c.145T > C
2705
GJB1
[′AGAGAGTGTGTGGGGTGATGAGAAAYCTTC

(p.Ser49Pro)

CTTCATCTGCAACACACTCCA′]

1684-
NM_000186.3(CFH): c.3590T > C
3075
CFH
[′ATATCCCCGTTTACACACAAATTCARCTGAT

1686
(p.Val1197Ala)

TCACCTGTTCTCGAATAAAG′,

′GAACTTATCATTGCTGCTTTTGATTaagatat

tggtcaaagagtacaaact′,

′ttcagctataatatgaataagaacttggaatc

aaacatagagatctagtga′]

1687
NM_000195.4(HPS1): c.2003T >
3257
HPS
[′GGGGATGACAGACAGGTGCAGGGCCRGCAG

C (p.Leu668Pro)

CTCGTAGCACCTGACAGCCTC′]

1688
NM_000195.4(HPS1): c.716T > C
3257
HPST
[′GCTGGGGTAGAGGTCCTGAACCAGGRGGAT

(p.Leu239Pro)

GAGGGCAAGCAGGTCGGCCGG′]

1689
NM_000334.4(SCN4A):
6329
SCN4A
[′CCTCTTCAACATCGGCCTCCTCCTCYTCCTG

c.4468T > C (p.Phe1490Leu)

GTCATGTTCATCTACTCCAT′]

1690
NM_000352.4(ABCC8): c.257T >
6833
ABCC8
[′ACCTTCATGCTGCTCTTCGTCCTGGBGTGTG

C (p.Val86Ala)

AGATTGCAGAGGGCATCCTG′]

1691
NM_000352.4(ABCC8): c.404T >
6833
ABCC8
[′ATCGAGACTTCCAACTTCCCCAAGCYGCTAA

C (p.Leu135Pro)

TTGGTAGGTGAGGTGTAGGA′]

1692
NM_000352.4(ABCC8): c.674T >
6833
ABCC8
[′TTCCTGCAGCCCTTCGTGAATCTGCYGTCCA

C (p.Leu225Pro)

AAGGCACCTACTGGTGGATG′]

1693
NM_000430.3(PAFAH1B1):
5048
PAFAH1B1
[′ATTACTTCATAATATATTGCTGTTAYGTGTTT

c.569 − 10T > C

TAGGCCATGACCACAATGT′]

1694
NM_000525.3(KCNJ11):
3767
KCNJ11
[′CCGTGCCCGCCAGCGGAGGGCCCGCBTTGT

c.103T > C (p.Phe35Leu)

GTCCAAGAAAGGCAACTGCAA′]

1695
NM_000525.3(KCNJ11):
3767
KCNJ11
[′GTGGGTGGCAACAGCATCTTCCTGGYGGCC

c.755T > C (p. Val252Ala)

CCGCTGATCATCTACCATGTC′]

1696
NM_000528.3(MAN2B1):
4125
MAN2B1
[′GGCAGCAGCCTGAGAGATGGCTCGCYGGAG

c.2426T > C (p.Leu809Pro)

CTCATGGTGAGTGGGTCAGAG′]

1697
NM_001034850.2(FAM134B):
54463
FAM134B
[′GACTTTTCAGCTCTTTGTCCTAAGGYATTTTT

c.873 + 2T > C

TGTTTAGTTTTCAATTTGT′]

1698
NM_001457.3(FLNB): c.4804T >
2317
FLNB
[′CTACGGGGGTGACGACATCCCACTTYCTCCT

C (p.Ser1602Pro)

TATCGCATCCGAGCCACACA′]

1699
NM_002863.4(PYGL): c.2461T >
5836
PYGL
[′CTCCAGTGACCGAACAATTAAAGAAYATGC

C (p.Tyr821His)

CCAAAACATCTGGAACGTGGA′]

1700
NM_003002.3(SDHD): c.284T > C
6392
SDHD
[′CCTTGCTCTGCGATGGACTATTCCCYGGCTG

(p.Leu95Pro)

CAGCCCTCACTCTTCATGGT′]

1701
NM_004385.4(VCAN):
1462
VCAN
[′TAAGTATTGTGAAAACTCTGTTTTTHTCAGG

c.4004 − 5T > C

TCGAATGAGTGATTTGAGTG′]

1702
NM_004519.3(KCNQ3): c.925T >
3786
KCNQ3
[′TGAGACCTATGCAGATGCCCTGTGGYGGGG

C (p.Trp309Arg)

CCTGGTGAGTCACTACCTTGG′]

1703
NM_004937.2(CTNS): c.473T > C
1497
CTNS
[′TCCACCCCCTGCAGTGTCATTGGTCYGAGCT

(p.Leu158Pro)

TCGACTTCGTGGCTCTGAAC′]

1704
NM_006329.3(FBLN5): c.649T >
10516
FBLN5
[′GAACGAGTGTGCCACCGAGAACCCCYGCGT

C (p.Cys217Arg)

GCAAACCTGCGTCAACACCTA′]

1705
NM_006432.3(NPC2): c.295T > C
10577
NPC2
[′TGATGGTTGTAAGAGTGGAATTAACYGCCCT

(p.Cys99Arg)

ATCCAAAAAGACAAGACCTA′]

1706
NM_007375.3(TARDBP):
23435
TARDBP
[′CATGGTAAGTATATTGTAAAATACAYATGTA

c.*83T > C

CTAAGAATTTTCAAAATTGG′]

1707
NM_013246.2(CLCF1): c.46T > C
−1
—
[′CTCGTGGGGGATGTTAGCGTGCCTGYGCAC

(p.Cys16Arg)

GGTGCTCTGGCACCTCCCTGC′]

1708
NM_013246.2(CLCF1): c.676T >
−1
—
[′CCTGCACCTGGGGGCTCATGGCTTCYGACTT

C (p.Ter226Arg)

CTGACCTTCTCCTCTTCGCT′]

1709
NM_024577.3(SH3TC2):
79628
SH3TC2
[′CTGCCCTTTGCCGAGCGCCTGCAGCYCCTCT

c.1982T > C (p.Leu661Pro)

CTGGACACCCTCCTGCCTCT′]

1710
NM_172107.2(KCNQ2): c.2T > C
3785
KCNQ2
[′CCGGGGCGCCTCCCGCCAGGCACCAYGGTG

(p.Met1Thr)

CAGAAGTCGCGCAACGGCGGC′]

1711
NM_004304.4(ALK): c.3749T > C
238
ALK
[′TGCATTTCCTTTCTTCCCAGAGACAYTGCTG

(p.Ile1250Thr)

CCAGAAACTGCCTCTTGACC′]

1712
NM_000495.4(COL4A5):
1287
COL4A5
[′TTCCTTCTCCTTTTCCTTTACCAGAYGTGCAG

c.4690T > C (p.Cys1564Arg)

TATGTGAAGCTCCAGCTGT′]

1713
NM_000495.4(COL4A5):
1287
COL4A5
[′CTTTTCCTTTACCAGATGTGCAGTAYGTGAA

c.4699T > C (p.Cys1567Arg)

GCTCCAGCTGTGGTGATCGC′]

1714
NM_000495.4(COL4A5):
1287
COL4A5
[′CAGTCAGACGATCCAGATTCCCCATYGTCCT

c.4756T > C (p.Cys1586Arg)

CAGGGATGGGATTCTCTGTG′]

1715
NM_000495.4(COL4A5):
1287
COL4A5
[′TAAGAAGCTTAAACTTCAAACAGCTYCTATC

c.4803 + 121T > C

CAAGCACTGTGTTCCCCCTC′]

1716
NM_000495.4(COL4A5):
1287
COL4A5
[′AGACTTGAGGACACGAATTAGCCGAYGTCA

c.5032T > C (p.Cys1678Arg)

AGTGTGCATGAAGAGGACATA′]

1717
NM_005359.5(SMAD4): c.970T >
4089
SMAD4
[′ATTTCCTATAGCTCCTGAGTATTGGYGTTCC

C (p.Cys324Arg)

ATTGCTTACTTTGAAATGGA′]

1718
NM_005359.5(SMAD4):
4089
SMAD4
[′GGACCCTTCTGGAGGAGATCGCTTTYGTTTG

c.1087T > C (p.Cys363Arg)

GGTCAACTCTCCAATGTCCA′]

1719
NM_005359.5(SMAD4):
4089
SMAD4
[′ATTGAAATTCACTTACACCGGGCCCBCCAGC

c.1598T > C (p.Leu533Pro)

TCCTAGACGAAGTACTTCAT′]

1720
NM_020630.4(RET): c.1831T > C
5979
RET
[′TAAAGCTGGCTATGGCACCTGCAACNGCTTC

(p.Cys611Arg)

CCTGAGGAGGAGAAGTGCTT′]

1721
NM_020630.4(RET): c.1888T > C
5979
RET
[′ACCACCCCCACCCACAGATCCACTGYGCGA

(p.Cys630Arg)

CGAGCTGTGCCGCACGGTGAT′]

1722
NM_000060.3(BTD): c.248T > C
686
BTD
[′GCTCTCATCAGCCGCCAAGAGGCCTYGGAG

(p.Leu83Ser)

CTCATGAACCAGAACCTTGAC′]

1723
NM_000060.3(BTD): c.445T > C
686
BTD
[′GAACCCATGCCTGGAGCCTCACCGCYTCAAT

(p.Phe149Leu)

GACACAGAGGTGATTCCTGC′]

1724
NM_000060.3(BTD): c.743T > C
686
BTD
[′TTTGGCATCTTCACATGCTTTGATAYATTGTT

(p.Ile248Thr)

CTTTGACCCTGCCATCAGA′]

1725
NM_000060.3(BTD): c.764T > C
686
BTD
[′GATATATTGTTCTTTGACCCTGCCAYCAGAG

(p.Ile255Thr)

TCCTCAGAGACTACAAGGTG′]

1726
NM_000060.3(BTD): c.833T > C
686
BTD
[′ACTGCCTGGATGAACCAGCTCCCACYCTTGG

(p.Leu278Pro)

CAGCAATTGAGATTCAGAAA′]

1727
NM_000060.3(BTD): c.1096T > C
686
BTD
[′CCATAGTAAGTTTTTAAAAATTTTGYCAGGC

(p.Ser366Pro)

GATCCGTACTGTGAGAAGGA′]

1728
NM_000060.3(BTD): c.1214T > C
686
BTD
[′GAGATGATGTATGACAATTTCACCCYGGTCC

(p.Leu405Pro)

CTGTCTGGGGAAAGGAAGGC′]

1729
NM_000060.3(BTD): c.1252T > C
686
BTD
[′GGGAAAGGAAGGCTATCTCCACGTCYGTTC

(p.Cys418Arg)

CAATGGCCTCTGCTGTTATTT′]

1730
NM_000060.3(BTD): c.1267T > C
686
BTD
[′TCTCCACGTCTGTTCCAATGGCCTCYGCTGT

(p.Cys423Arg)

TATTTACTTTACGAGAGGCC′]

1731
NM_000060.3(BTD): c.1459T > C
686
BTD
[′CACGGGGATATTTGAGTTTCACCTGYGGGGC

(p.Trp487Arg)

AACTTCAGTACTTCCTATAT′]

1732
NM_000155.3(GALT): c.265T > C
2592
GALT
[′TCCTTGTCGGTAGGTGAATCCCCAGBACGAT

(p.Tyr89His)

AGCACCTTCCTGTTTGACAA′]

1733
NM_000155.3(GALT):
2592
GALT
[′TGCAGCCTGATGCCCCCAGTCCAGGYAACCT

c.328 + 2T > C

GGCTCCAACTGCTGCTGGGG′]

1734
NM_000155.3(GALT): c.336T > C
2592
GALT
[′GATACTCCTTTACCTCAGGACCCAGYGATCA

(p.Ser112=)

TCCCCTTTTCCAAGCAAAGT′]

1735
NM_000155.3(GALT): c.350T > C
2592
GALT
[′TCAGGACCCAGTGATCATCCCCTTTYCCAAG

(p.Phe117Ser)

CAAAGTCTGCTCGAGGAGTC′]

1736
NM_000155.3(GALT): c.374T > C
2592
GALT
[′TTCCAAGCAAAGTCTGCTCGAGGAGYCTGG

(p.Val125Ala)

TAACTATGGATTTCCCCTCTT′]

1737
NM_000155.3(GALT): c.425T > C
2592
GALT
[′TGGTCGGATGTAACGCTGCCACTCAHGTCGG

(p.Met142Thr)

TCCCTGAGATCCGGGCTGTT′]

1738
NM_000155.3(GALT): c.452T > C
2592
GALT
[′TCGGTCCCTGAGATCCGGGCTGTTGYTGATG

(p.Val151Ala)

CATGGGCCTCAGTCACAGAG′]

1739
NM_000155.3(GALT): c.460T > C
2592
GALT
[′TGAGATCCGGGCTGTTGTTGATGCABGGGCC

(p.Trp154Arg)

TCAGTCACAGAGGAGCTGGG′]

1740
NM_000155.3(GALT): c.482T > C
2592
GALT
[′GCATGGGCCTCAGTCACAGAGGAGCYGGGT

(p.Leu161Pro)

GCCCAGTACCCTTGGGTGCAG′]

1741
NM_000155.3(GALT): c.499T > C
2592
GALT
[′AGAGGAGCTGGGTGCCCAGTACCCTYGGGT

(p.Trp167Arg)

GCAGGTTTGTGAGGTCGCCCC′]

1742
NM_000155.3(GALT):
2592
GALT
[′GGTGCCCAGTACCCTTGGGTGCAGGYTTGTG

c.507 + 2T > C

AGGTCGCCCCTTCCCCTGGA′]

1743
NM_000155.3(GALT): c.509T > C
2592
GALT
[′GAGCTCCGTATCCCTATCTGATAGAHCTTTG

(p.Ile170Thr)

AAAACAAAGGTGCCATGATG′]

1744
NM_000155.3(GALT): c.584T > C
2592
GALT
[′TGACAGGTATGGGCCAGCAGTTTCCYGCCA

(p.Leu195Pro)

GATATTGCCCAGCGTGAGGAG′]

1745
NM_000155.3(GALT): c.650T > C
2592
GALT
[′TATAAGAGTCAGCATGGAGAGCCCCYGCTA

(p.Leu217Pro)

ATGGAGTACAGCCGCCAGGAG′]

1746
NM_000155.3(GALT): c.677T > C
2592
GALT
[′CTAATGGAGTACAGCCGCCAGGAGCYACTC

(p.Leu226Pro)

AGGAAGGTGGGAGAGAGCCAA′]

1747
NM_000155.3(GALT):
2592
GALT
[′AGCCGCCAGGAGCTACTCAGGAAGGYGGGA

c.687 + 2T > C

GAGAGCCAAGCCCTGTGTCCC′]

1748
NM_000155.3(GALT): c.745T > C
2592
GALT
[′AGTACTGGTCCCCTTCTGGGCAACAYGGCCC

(p.Trp249Arg)

TACCAGACACTGCTGCTGCC′]

1749
NM_000155.3(GALT): c.967T > C
2592
GALT
[′CCATTGGCAGCTGCACGCTCATTACBACCCT

(p.Tyr323His)

CCGCTCCTGCGCTCTGCCAC′]

1750
NM_000155.3(GALT): c.980T > C
2592
GALT
[′CACGCTCATTACTACCCTCCGCTCCYGCGCT

(p.Leu327Pro)

CTGCCACTGTCCGGAAATTC′]

1751
NM_000155.3(GALT): c.1138T >
2592
GALT
[′GGACAGGGAGACAGCAACCATCGCCYGACC

C (p.Ter380Arg)

ACGCCGACCACAGGGCCTTGA′]

1752
NM_207346.2(TSEN54):
283989
TSEN54
[′AGAAGAGGGCTTCGTGGAGTTGAAGYCTCC

c.277T > C (p.Ser93Pro)

CGCGGTGAGCGGCGGGCTCGG′]

1753
NM_016269.4(LEF1): c.181T > C
−1
—
[′CATCAAGTCTTCCTTGGTGAACGAGYCTGAA

(p.Ser61Pro)

ATCATCCCGGCCAGCAACGG′]

1754
NM_001928.2(CFD): c.640T > C
1675
CFD
[′GGGTGACTCCGGGGGCCCGCTGGTGYGCGG

(p.Cys214Arg)

GGGCGTGCTCGAGGGCGTGGT′]

1755
NM_001458.4(FLNC): c.752T > C
2318
FLNC
[′CCCAACGTGGATGAGCATTCTGTTAYGACCT

(p.Met251Thr)

ACCTGTCCCAGTTCCCCAAG′]

1756
NM_000781.2(CYP11A1):
1583
CYP11A1
[′ATTTTTGGGGAGCGCCAGGGGATGCYGGAG

c.665T > C (p.Leu222Pro)

GAAGTAGTGAACCCCGAGGCC′]

1757-
NM_000782.4(CYP24A1):
1591
CYP24A1
[′ATAATAATGATGGTTGccaacatgcgctgag

1761
c.1226T > C (p.Leu409Ser)

tgcttaaaatgtgccaggta′,

′ataaataggtaaagggctttagaattgtgcac

catactcacaaccaccctg′,

′cgcagcagattctgttattaaaccccttttac

agacgaagttgaggctcac′,

′agagattatgtaactcactcaagacaacacag

ataaaagatgaaactgaat,

′ACAAATTCTACTTACTCCTTTGGGTRAAGCAT

ATTCACCCAGAACTGTTGC′]

1762
NM_001145661.1(GATA2):
2624
GATA2
[′CAACGGGGACCCTGTCTGCAACGCCYGTGG

c.1117T > C (p.Cys373Arg)

CCTCTACTACAAGCTGCACAA′]

1763
NM_004523.3(KIF11):
3832
KIF11
[′CAGGAACTTCACAACTTATTGGAGGYAATA

c.2547 + 2T > C

ACTTTGTAAGTGGAACTTACT′]

1764
NM_000238.3(KCNH2):
3757
KCNH2
[′GGGCGGCCCCTCCATCAAGGACAAGBATGT

c.1831T > C (p.Tyr611His)

GACGGCGCTCTACTTCACCTT′]

1765
NM_002465.3(MYBPC1):
4604
MYBPC1
[′GGAGGAAGAACCCCAGGTGGACGTAYGGGA

c.706T > C (p.Trp236Arg)

GTTGCTGAAGAACGCGAAACC′]

1766
NM_002465.3(MYBPC1):
4604
MYBPC1
[′CATTCCAAGACACCTGAAGCAAACCYATAT

c.2566T > C (p.Tyr856His)

CCGCAGAGTTGGAGAAGCTGT′]

1767
NM_005211.3(CSF1R): c.2624T >
1436
CSF1R
[′AAACTGGTGAAGGATGGATACCAAAYGGCC

C (p.Met875Thr)

CAGCCTGCATTTGCCCCAAAG′]

1768
NM_005211.3(CSF1R): c.2381T >
1436
CSF1R
[′TTGACCAATGGTCATGTGGCCAAGAYTGGG

C (p.Ile794Thr)

GACTTCGGGCTGGCTAGGGAC′]

1769
NM_003392.4(WNT5A):
7474
WNT5A
[′GCCGCGGGACTGGCTCTGGGGCGGCYGCGG

c.544T > C (p.Cys182Arg)

CGACAACATCGACTATGGCTA′]

1770
NM_005188.3(CBL): c.1150T > C
867
CBL
[′CTCCACATTCCAACTATGTAAAATABGTGCT

(p.Cys384Arg)

GAAAATGATAAGGATGTAAA′]

1771
NM_005188.3(CBL): c.1186T > C
867
CBL
[′TGATAAGGATGTAAAGATTGAGCCCYGTGG

(p.Cys396Arg)

ACACCTCATGTGCACATCCTG′]

1772
NM_006902.4(PRRX1): c.338T >
5396
PRRX1
[′CAGCTGCAGGCTTTGGAGCGTGTCTYTGAGC

C (p.Phe113Ser)

GGACACACTATCCTGATGCT′]

1773
NM_001111035.1(ACP5):
−1
—
[′GCGGCGGCCAGGGAGGACTACGTGCYGGTG

c.602T > C (p.Leu201Pro)

GCTGGCCACTACCCCGTGTGG′]

1774
NM_000329.2(RPE65): c.1102T >
6121
RPE65
[′GGCTCCCCAACCTGAAGTTAGGAGAYATGT

C (p.Tyr368His)

ACTTCCTTTGAATATTGACAA′]

1775
NM_003172.3(SURF1): c.679T >
6834
SURF1
[′TGAGAACAATCCAGAAAGGAACCACYGGCA

C (p.Trp227Arg)

TTATCGAGACCTGGAAGCTAT′]

1776
NM_002734.4(PRKARIA):
5573
PRKARIA
[′CATCCTCAAACGAAACATCCAGCAGYACAA

c.1117T > C (p.Tyr373His)

CAGTTTTGTGTCACTGTCTGT′]

1777
NM_002734.4(PRKARIA):
5573
PRKARIA
[′CCATCTTTGCTTTCTCCAGGTGAAAYTGCAC

c.980T > C (p.Ile327Thr)

TACTGATGAATCGTCCTCGT′]

1778
NM_003491.3(NAA10): c.109T >
8260
NAA10
[′GAAATACTACTTCTACCATGGCCTTYCCTGG

C (p.Ser37Pro)

CCCCAGGTGGGCAGCTTCTG′]

1779
NM_006306.3(SMC1A):
8243
SMC1A
[′GTGTTTGAAGAGTTTTGTCGGGAGAYTGGTG

c.2351T> C (p.Ile784Thr)

TGCGCAACATCCGGGAGTTT′]

1780
NM_000377.2(WAS): c.814T > C
7454
WAS
[′CGACCCAGATCTGCGGAGTCTGTTCYCCAGG

(p.Ser272Pro)

GCAGGAATCAGCGAGGCCCA′]

1781
NM_000377.2(WAS): c.881T > C
7454
WAS
[′ACCTCTAAACTTATCTACGACTTCAYTGAGG

(p.Ile294Thr)

ACCAGGGTGGGCTGGAGGCT′]

1782
m.12338T > C
4540
MT-ND5
[′TTGGTGCAACTCCAAATAAAAGTAAYAACC

ATGCACACTACTATAACCACC′]

1783
m.5814T > C
4511
MT-TC
[′TCGAATTTGCAATTCAATATGAAAAYCACCT

CGGAGCTGGTAAAAAGAGGC′]

1784
m.12201T > C
4564
MT-TH
[′GACAACAGAGGCTTACGACCCCTTAYTTACC

GAGAAAGCTCACAAGAACTG′]

1785
NM_001165899.1(PDE4D):
5144
PDE4D
[′GGAGATGACTTGATTGTGACTCCATBTGCTC

c.494T > C (p.Phe165Ser)

AGGTAAGCACAGCTTGGTGA′]

1786
NM_139125.3(MASP1):
5648
MASP1
[′GTTACCCGTGGTGCCTCACGCTGAGYGCAA

c.1888T > C (p.Cys630Arg)

AACTAGCTATGAGTCCCGCTC′]

1787
NM_007315.3(STAT1): c.520T >
6772
STAT1
[′TTTACAAGATGAATATGACTTCAAAYGCAA

C (p.Cys174Arg)

AACCTTGCAGAACAGAGGTAA′]

1788
NM_053025.3(MYLK): c.5275T >
−1
—
[′TGCTGTGAGAGCCATTGGAAGACTGYCCTCT

C (p.Ser1759Pro)

ATGGCAATGATCTCAGGGCT′]

1789
NM_001235.3(SERPINH1):
871
SERPINH1
[′TCACCCGTGGTGGTGGCCTCGTCGCYAGGGC

c.233T > C (p.Leu78Pro)

TCGTGTCGCTGGGCGGCAAG′]

1790
NM_005921.1(MAP3K1):
4214
MAP3K1
[′GAGGAACGAATGATCAGGGAGAAACBGAA

c.566T > C (p.Leu189Pro)

GGCAACCTGTATGCCAGCCTGG′]

1791
NM_005359.5(SMAD4):
4089
SMAD4
[′GTTGATGACCTTCGTCGCTTATGCAYACTCA

c.1499T > C (p.Ile500Thr)

GGATGAGTTTTGTGAAAGGC′]

1792
NM_000287.3(PEX6): c.1601T >
5190
PEX6
[′CTGTTGCTCACAGCTGTGGACCTTCYGGGCC

C (p.Leu534Pro)

GGGACCGTGATGGGCTGGGT′]

1793
NM_004153.3(ORC1): c.266T > C
4998
ORC1
[′AAGAAACGTGCTCGAGTACAGTGGTYTGTC

(p.Phe89Ser)

CGATTCTGTGAAGTCCCTGCC′]

1794
NM_006225.3(PLCD1): c.562T >
5333
PLCD1
[′CTCGGCTGTCCTGGCTCTGCAGGAGYGTGAC

C (p.Cys188Arg)

CACTCCCAGACAGACTCCCT′]

1795
NM_021252.4(RAB18): c.619T >
22931
RAB18
[′CTGTGGTGGTTATTGCTCTGTGTTAYAAACT

C (p.Ter207Gln)

CTGGGAAATTCCATCTCTTG′]

1796
NM_002242.4(KCNJ13):
−1
—
[′TGGTGTAATGGAGTGATAGTACGTTDGTGG

c.722T > C (p.Leu241Pro)

AAAGATGAAGAATGGACATTC′]

1797
NM_003072.3(SMARCA4):
6597
SMARCA4
[′CTGCAGCGAGTGCTCTACCGCCACAYGCAG

c.3032T > C (p.Met1011Thr)

GCCAAGGGCGTGCTGCTGACT′]

1798
NM_013339.3(ALG6): c.391T > C
29929
ALG6
[′GAGATTTCTTTTAAGCAACAACAGTRCAAAA

(p.Tyr131His)

CCACTGCAGGTATGTAAATC′]

1799
NM_019885.3(CYP26B1):
56603
CYP26B1
[′TTGCCTCTCTGCCTTCCAGGTCTTCYCCAAG

c.436T > C (p.Ser146Pro)

ATCTTCAGCCACGAGGCCCT′]

1800
NM_020433.4(JPH2): c.421T > C
57158
JPH2
[′GTTCACCAACGGCATGCGCCATGGCYACGG

(p.Tyr141His)

AGTACGCCAGAGCGTGCCCTA′]

1801
NM_000199.3(SGSH): c.892T > C
6448
SGSH
[′CCCCAGCGTTTTGGGTGCTCCGGGGRTGACA

(p.Ser298Pro)

CCAGTAAGGGTTCAGCAGTG′]

1802
NM_173170.1(IL36RN): c.80T >
26525
IL36RN
[′CTTTATCTGCATAATAACCAGCTTCYAGCTG

C (p.Leu27Pro)

GAGGGCTGCATGCAGGGAAG′]

1803
NM_016599.4(MYOZ2): c.142T >
51778
MYOZ2
[′CAGAGACATCATGTTGGAAGAATTAYCCCA

C (p.Ser48Pro)

TCTCAGTAACCGTGGTGCCAG′]

1804
NM_020191.2(MRPS22):
56945
MRPS22
[′CCAATAATTTTCAAGGAAGAAAATCYTAGG

c.644T > C (p.Leu215Pro)

GTAAGGTGACTTAGGTTTTAT′]

1805
NM_004278.3(PIGL): c.500T > C
9487
PIGL
[′TTGTCCTATCCCTCCTCCAGGGCCCYGCACT

(p.Leu167Pro)

CAGAAGGGAAGTTACCTAAA′]

1806
NM_022445.3(TPK1): c.119T > C
27010
TPK1
[′ATTTTGTTCTTTCTATTTGAAGCTCYTTTAAG

(p.Leu40Pro)

AGCCTGTGCCGATGGAGGT′]

1807
NM_020634.1(GDF3): c.914T > C
9573
GDF3
[′TGTCCCTTCTCACTGACCATCTCTCYCAACA

(p.Leu305Pro)

GCTCCAATTATGCTTTCATG′]

1808
NM_017882.2(CLN6): c.200T > C
54982
CLN6
[′CCCATTCTTCCATTTGCTCCGCAGCYGGTAT

(p.Leu67Pro)

TCCCTCTCGAGTGGTTTCCA′]

1809
NM_024513.3(FYCO1):
79443
FYCO1
[′TTTGTGAGGTCCAGCACCTACAGCCYGATCC

c.4127T > C (p.Leu1376Pro)

CCATCACTGTGGCCGAGGCA′]

1810
NM_006147.3(IRF6): c.65T > C
3664
IRF6
[′CTGGTGGCCCAGGTGGATAGTGGCCYCTAC

(p.Leu22Pro)

CCTGGGCTCATCTGGCTACAC′]

1811
NM_025132.3(WDR19):
57728
WDR19
[′GGAAATGTTGGCATAGTGATGTCCTYGGAA

c.2129T > C (p.Leu710Ser)

CAAATAAAGGTAAACAGCATG′]

1812
NM_025132.3(WDR19): c.20T >
57728
WDR19
[′TTTATTTTTTAGCGTATTTTCTCACYGCTAGA

C (p.Leu7Pro)

AAAGACTTGGCTTGGCGCA′]

1813
NM_153026.2(PRICKLE1):
144165
PRICKLE1
[′AAGTAAAAAATACCAGTCTGATATGYACTG

c.1414T > C (p.Tyr472His)

GGCACAGTCACAAGATGGACT′]

1814
NM_014874.3(MFN2):
9927
MFN2
[′GTAGTCCTCAAGGTTTATAAGAATGWGAGT

c.1392 + 2T > C

CATGGAGCAACAGGTCCTCTT′]

1815
NM_014874.3(MFN2): c.647T > C
9927
MFN2
[′GAGCTGGACAGCTGGATTGACAAGTYTTGT

(p.Phe216Ser)

CTGGATGCTGATGTGTTTGTG′]

1816
NM_016097.4(IER3IP1):
51124
IER3IP1
[′GTAAACTCAATTGCAATTGTGTTACYTTTAT

c.233T > C (p.Leu78Pro)

TATTTGGATGAATATCAGTG′]

1817
NM_018718.2(CEP41): c.107T >
95681
CEP41
[′TTCGAGCTTCTCAGTATATTTAGTCRTACTGT

C (p.Met36Thr)

TACCTAAAAAGAAAATAAG′]

1818
NM_022489.3(INF2): c.310T > C
64423
INF2
[′CCTGCTGCAGCTCACCTGCGTCAGCYGCGTG

(p.Cys104Arg)

CGCGCCGTCATGAACTCGCG′]

1819
NM_022489.3(INF2): c.383T > C
64423
INF2
[′AGCAACCAGGGCTACGTGCGCCAGCYCTCC

(p.Leu128Pro)

CAGGGTGAGCCGCAGTGTGGG′]

1820
NM_018713.2(SLC30A10):
55532
SLC30A10
[′GGCGCGCTGAGCAACGCGGTCTTCCYCACC

c.266T > C (p.Leu89Pro)

GCGCTCTGCTTCACCATCTTC′]

1821
NM_058246.3(DNAJB6):
10049
DNAJB6
[′CAGTCCATTTGAATTTGGCTTCACAYTCCGT

c.277T > C (p.Phe93Leu)

AACCCAGATGATGTCTTCAG′]

1822
NM_024753.4(TTC21B):
79809
TTC21B
[′CAAAAGAATTATCTTTGCTATGACCYGGCTG

c.2384T > C (p.Leu795Pro)

AGCTCTTATTAAAATTGAAA′]

1823
NM_032446.2(MEGF10):
84466
MEGF10
[′TGACTGCGACCACATTTCTGGGCAGYGTACT

c.2320T > C (p.Cys774Arg)

TGCCGCACTGGATTCATGGG′]

1824
NM_032446.2(MEGF10):
84466
MEGF10
[′CGTTCTCTGTGCTGAGACCTGCCAGYGTGTC

c.976T > C (p.Cys326Arg)

AACGGAGGGAAGTGTTACCA′]

1825
NM_024027.4(COLEC11):
78989
COLEC11
[′GAAGCGCTACGCGGACGCCCAGCTGYCCTG

c.505T > C (p.Ser169Pro)

CCAGGGCCGCGGGGGCACGCT′]

1826
NM_000035.3(ALDOB):
229
ALDOB
[′GCCCCAGAAGAACCCGTGTGAACATRCTGT

c.1027T > C (p.Tyr343His)

CCTTTGGCCGCCTGGCAGTTA′]

1827
NM_012338.3(TSPAN12):
23554
TSPAN12
[′CCTTCTATCATAATACAGAGCCCAGRGCAGA

c.734T > C (p.Leu245Pro)

GTAATGGTGAGAATCATGGC′]

1828
NM_001159772.1(CANT1):
124583
CANT1
[′CTCCTTGCCCAGGCCGCCCACGTACRGACGC

c.671T > C (p.Leu224Pro)

TCGTCCTTCACTGCCAGCCA′]

1829
NM_001006657.1(WDR35):
57539
WDR35
[′TGGCATGTACGTAGTAGGCATCCAGYGGAA

c.781T > C (p.Trp261Arg)

CCACATGGGCAGCGTGTTAGC′]

1830
NM_000420.2(KEL): c.1790T > C
3792
KEL
[′TCAACAGTACTGCCTGGGGGCTGCCYCGCCT

(p.Leu597Pro)

GTGACAACCATGCCCTCCAG′]

1831
NM_001243473.1(B9D1):
27077
B9D1
[′AGGGCCCAGGTCAGAATGAGGACCTRCCGG

c.400 + 2T > C

CCAGGTGAGAAGGGCACGTGC′]

1832
NM_015175.2(NBEAL2):
23218
NBEAL2
[′ATTGCAGTCCATGTAGTCAGAGTGCYGACCT

c.1163T > C (p.Leu388Pro)

GCATCATGAGTGACTCCCCC′]

1833
NM_000196.3(HSD11B2):
3291
HSD11B2
[′GCTGGCAGCTCGGCCCCGCCGCCGCYATTAC

c.1012T > C (p.Tyr338His)

CCCGGCCAGGGCCTGGGGCT′]

1834
NM_024599.5(RHBDF2):
79651
RHBDF2
[′GCTTACCGCCCCCCTCCCTTCCAGAYTGTGG

c.557T > C (p.Ile186Thr)

ATCCGCTGGCCCGGGGCCGG′]

1835
NM_001256714.1(DNAAF3):
352909
DNAAF3
[′GGCTCTGTGGATGGACGGCACCTGCYGCGG

c.386T > C (p.Leul29Pro)

ACCCTGTCCCGAGCGAAGTTC′]

1836
NM_020894.2(UVSSA): c.94T > C
57654
UVSSA
[′GAAAATGAAGGAACTGAAGAAAATTYGCAA

(p.Cys32Arg)

GTATGTCTTAGGGTTCAGTAA′]

1837
NM_004453.3(ETFDH):
2110
ETFDH
[′TTGTTTCCTCAGTCTATACCAAAACYCACCT

c.1130T > C (p.Leu377Pro)

TTCCTGGTGGTTTACTAATT′]

1838
NM_024306.4(FA2H): c.707T > C
79152
FA2H
[′CTCATCGAGTACCTCATCCACCGCTYCCTGT

(p.Phe236Ser)

TCCACATGAAGCCCCCCAGC′]

1839
NM_001004127.2(ALG11):
−1
—
[′AAAATAAACATTCCATTTGATGAATYAAAG

c.1142T > C (p.Leu381Ser)

AATTATTTGTCTGAAGCAACA′]

1840
NM_021167.4(GATAD1):
57798
GATAD1
[′TCGGCTCAGAAACACTAAATACAAAYCTGC

c.304T > C (p.Ser102Pro)

TCCGGCTGCTGAAAAGAAAGT′]

1841
NM_016042.3(EXOSC3):
51010
EXOSC3
[′AGTATTTGGAATGAATGGAAGAATAYGGGT

c.712T > C (p.Trp238Arg)

TAAGGCAAAAACCATCCAGCA′]

1842
NM_001018005.1(TPM1):
7168
TPM1
[′CAGGTGGCCCGTAAGCTGGTCATCAYTGAG

c.515T > C (p.Ile172Thr)

AGCGACCTGGAACGTGCAGAG′]

1843
NM_001018005.1(TPM1):
7168
TPM1
[′GAGCTGGACCACGCTCTCAACGATAYGACT

c.842T > C (p.Met281Thr)

TCCATGTAAACGTTCATCCAC′]

1844
NM_033360.3(KRAS): c.211T > C
3845
KRAS
[′GGAGTACAGTGCAATGAGGGACCAGYACAT

(p.Tyr71His)

GAGGACTGGGGAGGGCTTTCT′]

1845
NM_006218.2(PIK3CA):
5290
PIK3CA
[′TTTTTCTTTGTTTTTTAAGGAACACYGTCCAT

c.1258T > C (p.Cys420Arg)

TGGCATGGGGAAATATAAA′]

1846
NM_006265.2(RAD21):
−1
—
[′TGAATCTATCAGTTTGCTTGAGTTAYGTCGA

c.1753T > C (p.Cys585Arg)

AATACGAACAGAAAACAAGC′]

1847
NM_000222.2(KIT): c.1859T > C
3815
KIT
[′ATTAAGTCAGATGCGGCCATGACTGYCGCT

(p.Val620Ala)

GTAAAGATGCTCAAGCGTAAG′]

1848
NM_000076.2(CDKNIC):
1028
CDKNIC
[′CGCGCGCTGTCGCCCGCAGATTTCTYCGCCA

c.827T > C (p.Phe276Ser)

AGCGCAAGAGATCAGCGCCT′]

1849
NM_005691.3(ABCC9):
10060
ABCC9
[′AGACTATTGGCTGGCCACATGGACAYCGGA

c.3058T > C (p.Ser1020Pro)

GTACAGTATAAACAATACTGG′]

1850
NM_012343.3(NNT): c.2930T > C
23530
NNT
[′ATGCCTGGTCAGCTTAATGTGCTGCYGGCTG

(p.Leu977Pro)

AGGCTGGTGTGCCATATGAC′]

1851
NM_024110.4(CARD14):
79092
CARD14
[′GTGCTGCTGCGGCGGTGCCAGCAGCYGCAG

c.467T > C (p.Leu156Pro)

GAGCACCTGGGCCTGGCCGAG′]

1852
NM_000492.3(CFTR): c.1400T >
1080
CFTR
[′GATGGGTTTTATTTCCAGACTTCACYTCTAA

C (p.Leu467Pro)

TGGTGATTATGGGAGAACTG′]

1853
NM_000518.4(HBB): c.2T > C
3043
HBB
[′CACTAGCAACCTCAAACAGACACCANGGTG

(p.Met1Thr)

CATCTGACTCCTGAGGAGAAG′]

1854
NM_000518.4(HBB): c.*110T > C
3043
HBB
[′CCTTGAGCATCTGGATTCTGCCTAAHAAAAA

ACATTTATTTTCATTGCAAT′]

1855
NM_000518.4(HBB):
3043
HBB
[′AGTTGGTGGTGAGGCCCTGGGCAGGNTGGT

c.92 + 2T > C

ATCAAGGTTACAAGACAGGTT′]

1856
NM_000206.2(IL2RG): c.455T >
3561
IL2RG
[′ACCACATATGCACACATATCTCCAGYGATCC

C (p.Val152Ala)

CCTGGGCTCCAGAGAACCTA′]

1857
NM_000244.3(MEN1): c.518T > C
4221
MEN1
[′GCTGTGGTTGGGGCCTGCCAGGCCCYGGGT

(p.Leu173Pro)

CTCCGGGATGTCCACCTCGCC′]

1858
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CCGCCATCGTAGGCAGGCGGCTCCCVCTGTA

c.2374T > C (p.Trp792Arg)

CTGTGCAGGAGTCCTCTCCC′]

1859
NM_002501.3(NFIX): c.179T > C
4784
NFIX
[′GAGGAGCGGGCGGTGAAGGACGAGCYGCTG

(p.Leu60Pro)

GGCGAGAAGCCCGAGATCAAG′]

1860
NM_005022.3(PFN1): c.341T > C
5216
PFN1
[′CCTCCTCCAGCGCTAGTCCTGCTGAYGGGCA

(p.Met114Thr)

AAGAAGGTGTCCACGGTGGT′]

1861
NM_001172567.1(MYD88):
4615
MYD88
[′CTTGCAGGTGCCCATCAGAAGCGACYGATC

c.818T > C (p.Leu273Pro)

CCCATCAAGTACAAGGCAATG′]

1862
NM_001161581.1(POC1A):
25886
POCIA
[′GCCAGTGATGACAAGACTGTTAAGCYGTGG

c.398T > C (p.Leu133Pro)

GACAAGAGCAGCCGGGAATGT′]

1863
NM_005270.4(GLI2): c.4663T > C
2736
GLI2
[′CCCCCGAAACTCCTTGACCCTGCCCYCCATC

(p.Ser1555Pro)

CCCGCAGGCATCAGCAACAT′]

1864
NM_152296.4(ATP1A3):
478
ATP1A3
[′CTCCTCCGCCTAGGTCCCTGCCATCYCACTG

c.2431T > C (p.Ser811Pro)

GCGTACGAGGCTGCCGAAAG′]

1865
NM_022787.3(NMNAT1):
64802
NMNAT1
[′GAGAAACACTGCAGAAGCTAAGACAYAGGA

c.838T > C (p.Ter280Gln)

ATTCTACAGCATGATATTTCA′]

1866
NM_005340.6(HINT1): c.250T >
3094
HINT1
[′ACACTTAATGATTGTTGGCAAGAAAYGTGCT

C (p.Cys84Arg)

GCTGATCTGGGCCTGAATAA′]

1867
NM_000155.3(GALT): c.416T > C
2592
GALT
[′TTCCACCCCTGGTCGGATGTAACGCYGCCAC

(p.Leu139Pro)

TCATGTCGGTCCCTGAGATC′]

1868
NM_000155.3(GALT): c.386T > C
2592
GALT
[′CTCCCGTCACCACCCAGTAAGGTCAYGTGCT

(p.Met129Thr)

TCCACCCCTGGTCGGATGTA′]

1869
NM_000155.3(GALT): c.680T > C
2592
GALT
[′ATGGAGTACAGCCGCCAGGAGCTACYCAGG

(p.Leu227Pro)

AAGGTGGGAGAGAGCCAAGCC′]

1870
NM_007294.3(BRCA1): c.4986 +
672
BRCA1
[′GCCTGACCCCAGAAGAATTTGTGAGBGTATC

6T > C

CATATGTATCTCCCTAATGA′]

1871
NM_007294.3(BRCA1): c.5074 +
672
BRCA1
[′CTACTCATGTTGTTATGAAAACAGGYATACC

2T > C

AAGAACCTTTACAGAATACC′]

1872
NM_007294.3(BRCA1):
672
BRCA1
[′GGTTTCTTTCAGCATGATTTTGAAGBCAGAG

c.5207T > C (p. Val1736Ala)

GAGATGTGGTCAATGGAAGA′]

1873
NM_002437.4(MPV17):
4358
MPV17
[′TGAAGCCCTGTTGAGGGGAGAACTTRCCAC

c.186 + 2T > C

AAAGCCACAGCCCAGGGACAC′]

1874
NM_002769.4(PRSS1): c.116T >
−1
—
[′GAGGAGAATTCTGTCCCCTACCAGGYGTCCC

C (p.Val39Ala)

TGAATTCTGGCTACCACTTC′]

1875
NM_004211.3(SLC6A5):
9152
SLC6A5
[′GATTTTCTTCTCTTTATCTGCTGCAYGGGGA

c.1444T > C (p.Trp482Arg)

GGCCTGATCACTCTCTCTTC′]

1876
NM_005211.3(CSF1R): c.2297T >
1436
CSF1R
[′TTCTCCAGCCAAGTAGCCCAGGGCAYGGCC

C (p.Met766Thr)

TTCCTCGCTTCCAAGAATGTG′]

1877
NM_005211.3(CSF1R): c.2546T >
1436
CSF1R
[′TATGGCATCCTCCTCTGGGAGATCTYCTCAC

C (p.Phe849Ser)

TTGGTGAGCCACTGGGCCCA′]

1878
NM_005211.3(CSF1R): c.2603T >
1436
CSF1R
[′CTGGTGAACAGCAAGTTCTATAAACBGGTG

C (p.Leu868Pro)

AAGGATGGATACCAAATGGCC′]

1879
NM_006796.2(AFG3L2):
10939
AFG3L2
[′ATTTTTCAGATTGTTCAGTTTGGCABGAATG

Tc.1997 > C (p.Met666Thr)

AAAAGGTTGGGCAAATCTCC′]

1880
NM_018713.2(SLC30A10):
55532
SLC30A10
[′GTAAGTGGAAAGATTATTGCCACCCYGCAC

c.1046T > C (p.Leu349Pro)

ATCAAGTATCCTAAGGACAGG′]

1881
NM_018713.2(SLC30A10):
55532
SLC30A10
[′GCGGAGGGCTGTGTCCCCGGCGCTTYCGGG

c.500T > C (p.Phe 167Ser)

GGGCCTCAGGGCGCGGAGGAC′]

1882
NM_000060.3(BTD): c.212T > C
686
BTD
[′TATGAGCATCCATCCATCCTGAGTCYGAACC

(p.Leu71Pro)

CTCTGGCTCTCATCAGCCGC′]

1883
NM_000495.4(COL4A5):
1287
COL4A5
[′TTTCCTGGTTTACAGGGTCCTCCAGYAAGTT

c.438 + 2T > C

ATAAAATTTGGGATTATGAT′]

1884
NM_000282.3(PCCA): c.491T > C
5095
PCCA
[′CAGGCAGCAGAAGATGTCGTTTTCAYTGGA

(p.Ile164Thr)

CCTGACACACATGCTATTCAA′]

1885
NM_000532.4(PCCB): c.1556T >
5096
PCCB
[′ACACGTGCCCGAATCTGCTGTGACCYGGAT

C (p.Leu519Pro)

GTCTTGGCCAGCAAGAAGGTA′]

1886
NM_001099274.1(TINF2):
26277
TINF2
[′CATAAGGAGCGCCCCACAGTCATGCYGTTTC

c.860T > C (p.Leu287Pro)

CCTTTAGGAATCTCGGCTCA′]

1887
NM_001099274.1(TINF2):
26277
TINF2
[′TAAGGAGCGCCCCACAGTCATGCTGYTTCCC

c.862T > C (p.Phe288Leu)

TTTAGGAATCTCGGCTCACC′]

1888
NM_001363.4(DKC1): c.1049T >
1736
DKC1
[′TCAATGCCTGTAGCTATTGCATTAAYGACCA

C (p.Met350Thr)

CAGCGGTCATCTCTACCTGC′]

1889
NM_001363.4(DKC1): c.1193T >
1736
DKC1
[′AAGCTGATGATCAAGCAGGGCCTTCYGGAC

C (p.Leu398Pro)

AAGCATGGGAAGCCCACAGAC′]

1890
NM_004614.4(TK2):
7084
TK2
[′CAGGAAAAAGAGAAAAAATCAGTGGYAAG

c.156 + 2T > C

TCCCTCTTTTATGTGTACTCTC′]

1891
NM_004614.4(TK2): c.644T > C
7084
TK2
[′GAATACCTGGAAGCAATTCACCATCYCCAT

(p.Leu215Pro)

GAGGAGTGGCTCATCAAAGGC′]

1892
NM_024312.4(GNPTAB):
79158
GNPTAB
[′ATCGAAGGGCTGTCCCAGAAGTTTAYTTACC

c.1208T > C (p.Ile403Thr)

TAAATGATGATGTCATGTTT′]

1893
NM_024312.4(GNPTAB):
79158
GNPTAB
[′TTTGCCTTCTCTTATTTTTATTATCYCATGAG

c.3002T > C (p.Leu1001Pro)

TGCAGTGCAGCCACTGAAT′]

1894
NM_198253.2(TERT): c.3043T >
7015
TERT
[′CCGCCATCCTCTCAGGTTTCACGCAYGTGTG

C (p.Cys1015Arg)

CTGCAGCTCCCATTTCATCA′]

1895
NM_207352.3(CYP4V2):
285440
CYP4V2
[′TACAACTGCAGCTGCAATAAACTGGYCCTTA

c.1021T > C (p.Ser341Pro)

TACCTGTTGGGTTCTAACCC′]

1896
NM_207352.3(CYP4V2):
285440
CYP4V2
[′TGCTCAAAGTAATGATGATTCCGAGYATGTC

c.655T > C (p.Tyr219His)

CGTGCAGTTTATAGGTAAAT′]

1897
NM_000335.4(SCN5A):
6331
SCN5A
[′GCCAAGCCCAACCAGATAAGCCTCAYCAAC

c.5504T > C (p.Ile1835Thr)

ATGGACCTGCCCATGGTGAGT′]

1898
NM_001111.4(ADAR): c.2615T >
103
ADAR
[′CTCGGCCGCAAGATTCTGGCCGCCAYCATTA

C (p.Ile872Thr)

TGAAAAAAGACTCTGAGGAC′]

1899
NM_004281.3(BAG3): c.1385T >
9531
BAG3
[′ATCGAAGAGTATTTGACCAAAGAGCYGCTG

C (p.Leu462Pro)

GCCCTGGATTCAGTGGACCCC′]

1900
NM_183075.2(CYP2U1):
113612
CYP2U1
[′TTTTATGTCACGAGGCCTAGAAATCYGTCTG

c.784T> C (p.Cys262Arg)

AACAGTCAAGTCCTCCTGGT′]

1901
NM_006177.3(NRL): c.287T > C
4901
NRL
[′TTGGGGCTGAGTCCTGAAGAGGCCAYGGAG

(p.Met96Thr)

CTGCTGCAGGGTCAGGGCCCA′]

1902
NM_000344.3(SMN1): c.388T > C
6606
SMN1
[′AACCTGTGTTGTGGTTTACACTGGAYATGGA

(p.Tyr130His)

AATAGAGAGGAGCAAAATCT′]

1903
NM_152692.4(C1GALT1C1):
29071
C1GALT1C1
[′AGGAGGAATTGTCTTAAGTGTAGAAYCAAT

c.577T > C (p.Ser193Pro)

GAAAAGACTTAACAGCCTTCT′]

1904
NM_024531.4(SLC52A2):
79581
SLC52A2
[′TTAGCACTGGCCTTTGTGCTGGCACYGGCAT

Tc.368 > C (p.Leu123Pro)

GCTGTGCCTCGAATGTCACT′]

1905
NM_001253816.1(SLC52A2):
79581
SLC52A2
[′GCTCACTGCAGGTCCTTGGCAGGGCYGGGC

c.1016T > C (p.Leu339Pro)

GGCCTCTCTCTGCTGGGCGTG′]

1906
NM_002609.3(PDGFRB):
5159
PDGFRB
[′TCGGAGCTGAAGATCATGAGTCACCYTGGG

c.1973T > C (p.Leu658Pro)

CCCCACCTGAACGTGGTCAAC′]

1907
NM_020822.2(KCNT1):
57582
KCNT1
[′CAACAGCTATGAAGACGCCAAGGCCYACGG

c.2386T > C (p.Tyr796His)

GTTCAAGAACAAGCTGATCAT′]

1908
NM_001369.2(DNAH5):
1767
DNAH5
[′ACTATAGATCATTTTAATTGCATTTRTAAGT

c.1121T > C (p.Ile374Thr)

GTAGGAATAGCATCCATCAT′]

1909
NM_017802.3(DNAAF5):
54919
DNAAF5
[′GTCCAGTACCTGTACCGAGAGTTGCYGGTTC

c.2384T > C (p.Leu795Pro)

ACCTTGACGATCCAGAGAGG′]

1910
NM_006383.3(CIB2): c.272T > C
10518
CIB2
[′GAGGGGAACCTCACTTTCAACGACTYTGTG

(p.Phe91Ser)

GACATGTTTTCCGTGCTCTGC′]

1911
NM_006383.3(CIB2): c.368T > C
10518
CIB2
[′ACAGACTTCAACACTGACAACTTCAYCTGCA

(p.Ile123Thr)

AGGAGGACCTGGAGCTGACG′]

1912
NM_005334.2(HCFC1):
3054
HCFC1
[′TTAGTTGTTACTTCTTCACACAAGAYGGCGG

c.−970T > C

CTCCCAGGGAGGAGGCATGA′]

1913
NM_178012.4(TUBB2B):
347733
TUBB2B
[′GGAGCCGAGCTGGTCGACTCGGTCCYGGAT

c.350T > C (p.Leu117Pro)

GTGGTGAGGAAGGAGTCAGAG′]

1914
NM_000431.3(MVK): c.764T > C
4598
MVK
[′GTGGCTGGCGTCAGAAACAGGCTGCYCAAG

(p.Leu255Pro)

GTGACTCTTGTTCCCTTCTTG′]

1915
NM_000431.3(MVK): c.122T > C
4598
MVK
[′TTGAACTTGAGAACATTCCTCCGGCYTCAAC

(p.Leu41Pro)

CCCACAGCAATGGGAAAGTG′]

1916
NM_000431.3(MVK):
4598
MVK
[′GTGGCATCACACTCCTCAAGCCAGGYATCCC

c.1039 + 2T > C

GGGGGTAGGTGGGCCAGGCT′]

1917
NM_000431.3(MVK): c.1094T >
4598
MVK
[′AAGCAGGCCCTGACCAGCTGTGGCTYTGAC

C (p.Phe365Ser)

TGCTTGGAAACCAGCATCGGT′]

1918
NM_004055.4(CAPN5): c.731T >
726
CAPN5
[′ACAGCAGCTGACATGGAGGCCCGCCYGGCG

C (p.Leu244Pro)

TGCGGCCTGGTAAAGGGCCAC′]

1919
NM_133497.3(KCNV2): c.491T >
169522
KCNV2
[′GCCGTCTTCCAGCTGGTCTACAATTYCTACC

C (p.Phe164Ser)

TGTCCGGGGTGCTGCTGGTG′]

1920
NM_006567.3(FARS2): c.986T >
10667
FARS2
[′ATGATCCTCTACGACATCCCTGATAYCCGTC

C (p.Ile329Thr)

TCTTCTGGTGTGAGGACGAG′]

1921
NM_020376.3(PNPLA2):
57104
PNPLA2
[′GCCTGCGCTTTCTGCAGCGGAACGGYGCGC

c.757 + 2T > C

GGACCCGGGCGGGAGAGGGCG′]

1922
NM_018344.5(SLC29A3):
55315
SLC29A3
[′TATGAGGAACTCCCAGGCACTGATAYCAGG

c.607T > C (p.Ser203Pro)

TGAGAGCCAGGGTCCGGGCAG′]

1923
NM_012275.2(IL36RN):
26525
IL36RN
[′TGCAGGGAAGGTCATTAAAGGTTGGYGATG

c.115 + 6T > C

AAACATGACCCACTTTCCTTG′]

1924
m.9191T > C
4508
MT-ATP6
[′TTCACACTTCTAGTAAGCCTCTACCYGCACG

ACAACACATAATGACCCACC′]

1925
NM_000108.4(DLD): c.140T > C
1738
DLD
[′GTAGTTGATGCTGATGTAACAGTTAYAGGTT

(p.Ile47Thr)

CTGGTCCTGGAGGATATGTT′]

1926
NM_000080.3(CHRNE): c.223T >
−1
—
[′AGAGGAGACTCTCACCACTAGCGTCYGGAT

C (p.Trp75Arg)

TGGAATCGTGAGTCAAATCTG′]

1927
NM_004376.5(COX15):
1355
COX15
[′TGCCATTACAGTGCTCTACTTCCTCBCTCGG

c.1030T > C (p.Ser344Pro)

AGAATTCCCCTTCCTAGAAG′]

1928
NM_004333.4(BRAF): c.1403T >
673
BRAF
[′GGACAAAGAATTGGATCTGGATCATYTGGA

C (p.Phe468Ser)

ACAGTCTACAAGGGAAAGTGG′]

1929
NM_004333.4(BRAF): c.1454T >
673
BRAF
[′TTAGGTGATGTGGCAGTGAAAATGTYGAAT

C (p.Leu485Ser)

GTGACAGCACCTACACCTCAG′]

1930
NM_005188.3(CBL): c.1201T > C
867
CBL
[′GATTGAGCCCTGTGGACACCTCATGYGCAC

(p.Cys401Arg)

ATCCTGTCTTACATCCTGGCA′]

1931
NM_002834.3(PTPN11): c.211T >
5781
PTPN11
[′CTATGACCTGTATGGAGGGGAGAAABTTGC

C (p.Phe71Leu)

CACTTTGGCTGAGTTGGTCCA′]

1932
NM_002834.3(PTPN11): c.853T >
5781
PTPN11
[′AAATAGATATAAAAACATCCTGCCCBGTAA

C (p.Phe285Leu)

GTATCAATATTCCGCTCAGTA′]

1933
NM_002880.3(RAF1): c.769T > C
5894
RAF1
[′AGGTTCCCTCTCCCAGAGGCAGAGGYCGAC

(p.Ser257Pro)

ATCCACACCTAATGTCCACAT′]

1934
NM_002880.3(RAF1): c.1423T >
5894
RAF1
[′AGTCCTTAACAAGCATTGAGATATAYTTCTC

C (p.Phe475Leu)

CATGAAGGCTTAACAGTGAA′]

1935
NM_005633.3(SOS1): c.806T > C
6654
SOS1
[′GGCCATATAGAAGATACAGTAGAAABGACA

(p.Met269Thr)

GATGAAGGCAGTCCCCATCCA′]

1936
NM_005633.3(SOS1): c.1649T >
6654
SOS1
[′ATATCTTTACAGTACCGGAGTACACYGGAA

C (p.Leu550Pro)

AGGATGCTTGATGTAACAATG′]

1937
NM_005633.3(SOS1): c.2104T >
6654
SOS1
[′TCGGCACTGGGTAGAGCACCACTTCYATGAT

C (p.Tyr702His)

TTTGAAAGAGATGCATATCT′]

1938
NM_002755.3(MAP2K1):
5604
MAP2K1
[′CAACTCTCCGTACATCGTGGGCTTCYATGGT

c.388T > C (p.Tyr130His)

GCGTTCTACAGCGATGGCGA′]

1939
NC_012920.1: m.7505T > C
4574
MT-TS1
[′TTTCAAGCCAACCCCATGGCCTCCAYGACTT

TTTCAAAAAGGTATTAGAAA′]

1940
NM_000084.4(CLCN5): c.674T >
1184
CLCN5
[′GTGGCTTGCTGCTGTGGGAACATCCYGTGCC

C (p.Leu225Pro)

ACTGCTTCAACAAATACAGG′]

1941
NM_000530.6(MPZ): c.89T > C
4359
MPZ
[′GCAGTGCTGTCCCCGGCCCAGGCCAYCGTG

(p.Ile30Thr)

GTTTACACCGACAGGGAGGTC′]

1942
NM_000530.6(MPZ): c.244T > C
4359
MPZ
[′CCCTCATTCCTCATAGATCTTCCACYATGCC

(p.Tyr82His)

AAGGGACAACCCTACATTGA′]

1943
NM_000530.6(MPZ): c.266T > C
4359
MPZ
[′CACTATGCCAAGGGACAACCCTACAHTGAC

(p.Ile89Thr)

GAGGTGGGGACCTTCAAAGAG′]

1944
NM_000748.2(CHRNB2):
1141
CHRNB2
[′TACCTCATGTTCACCATGGTGCTTGYCACCT

c.923T > C (p.Val308Ala)

TCTCCATCGTCACCAGCGTG′]

1945
NM_003611.2(OFD1):
8481
OFD1
[′CGGGGTATACTGGATACACTCAAGGYATCG

c.111 + 2T > C

GATTTAGGCGTATCTGTGTCA′]

1946
NM_003611.2(OFD1): c.274T > C
8481
OFD1
[′AAGATGTGGCTATGAATATTCACTTYCTGTT

(p.Ser92Pro)

TTCTTTCCAGAAAGTGGTTT′]

1947
NM_024408.3(NOTCH2):
4853
NOTCH2
[′GCCCCACCCTGTGACAGGTCTCCTGYGTCAT

c.1117T > C (p.Cys373Arg)

CTGGATGATGCATGCATCAG′]

1948
NM_024408.3(NOTCH2):
4853
NOTCH2
[′TCTGGATAAGATTGGAGGCTTCACAYGTCTG

c.1438T > C (p.Cys480Arg)

TGCATGCCAGGTAAATGGGC′]

1949
NM_000540.2(RYR1): c.9242T >
6261
RYR1
[′CCCCGCTGCCCTTCTAGGACAGTGAYGAAGT

C (p.Met3081Thr)

CAGGCCCTGAGATCGTGAAG′]

1950
NM_000096.3(CP): c.650T > C
1356
CP
[′AAAGAAAAACATATTGACCGAGAATYTGTG

(p.Phe217Ser)

GTGATGTTTTCTGTGGTGGAT′]

1951
NM_000096.3(CP): c.548T > C
1356
CP
[′GTGACTAGGATTTACCATTCCCACABTGATG

(p.Ile183Thr)

CTCCAAAAGATATTGCCTCA′]

1952
NM_000540.2(RYR1): c.1205T >
6261
RYR1
[′CAGGAGGAGTCCCAGGCCGCCCGCAYGATC

C (p.Met402Thr)

CACAGCACCAATGGCCTATAC′]

1953
NM_006517.4(SLC16A2):
6567
SLC16A2
[′TTCGGGGGCCTTATCGTCGTCTGTCYTTTCCT

c.1253T > C (p.Leu418Pro)

GGGCCTTTGCGATGGCTTC′]

1954
NM_000096.3(CP): c.1123T > C
1356
CP
[′CCGTGGGAAGCATGTTAGACACTACYACAT

(p.Tyr375His)

TGCCGCTGAGGAAATCATCTG′]

1955
NM_002739.3(PRKCG): c.391T >
5582
PRKCG
[′CGGGCTTGTGCACCAGGGCATGAAAHGCTC

C (p.Cys131Arg)

CTGTGAGTGACCTGGGCCTTG′]

1956
NM_000116.4(TAZ): c.310T > C
6901
TAZ
[′GACCCCTGCAGCTGCAGACATCTGCYTCACC

(p.Phe104Leu)

AAGGAGCTACACTCCCACTT′]

1957
NM_000138.4(FBN1): c.2341T >
2200
FBN1
[′CAGTCTCCTTTGTGACAATGGACAAYGTAGA

C (p.Cys781Arg)

AATACTCCTGGAAGTTTTGT′]

1958
NM_000138.4(FBN1): c.4222T >
2200
FBN1
[′CTTTCTGGCTGTAGACCTTGATGAGYGCTCT

C (p.Cys1408Arg)

GAGAACCTGAATCTCTGTGG′]

1959
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GTAGCACGGAGCTCTTTGTGAAAGGYGGGC

c.1351 + 2T > C

CTGGGACCTGAGGATGTGGGA′]

1960
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GACGCGGAAGTAGTAGCCATTGCCARTGAT

c.3392T > C (p.Ile1131Thr)

GAGCTCTGGCACCACGCAGTG′]

1961
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CCTCCTATCAGCCTTCCGCCGCACGYGAGTG

c.821 + 2T > C

GCCATCCTCAGGGCCTGGGG′]

1962
NM_000257.3(MYH7): c.1370T >
4625
MYH7
[′ACCAAGCAGCCACGCCAGTACTTCAYAGGA

C (p.Ile457Thr)

GTCCTGGACATCGCTGGCTTC′]

1963
NM_000257.3(MYH7): c.2093T >
4625
MYH7
[′ATGCACCAGCTGCGCTGCAATGGTGYGCTG

C (p. Val698Ala)

GAGGGCATCCGCATCTGCAGG′]

1964
NM_000257.3(MYH7): c.2546T >
4625
MYH7
[′AAGAGTGCAGAAAGAGAGAAGGAGAYGGC

C (p.Met849Thr)

CTCCATGAAGGAGGAGTTCACA′]

1965
NM_000257.3(MYH7): c.2555T >
4625
MYH7
[′GAAAGAGAGAAGGAGATGGCCTCCAHGAA

C (p.Met852Thr)

GGAGGAGTTCACACGCCTCAAA′]

1966
NM_000257.3(MYH7): c.602T >
4625
MYH7
[′CAGTACTTTGCTGTTATTGCAGCCAYTGGGG

C (p.Ile201Thr)

ACCGCAGCAAGAAGGACCAG′]

1967
NM_000257.3(MYH7): c.788T >
4625
MYH7
[′ACAGGAAAGTTGGCATCTGCAGACAYAGAG

C (p.Ile263Thr)

ACCTGTGAGTGCCATGAATCT′]

1968
NM_000260.3(MYO7A):
4647
MYO7A
[′CTCCTGCCCCACGTGCAGCGCTTCCYGCAGT

c.5573T > C (p.Leu1858Pro)

CCCGAAAGCACTGCCCACTC′]

1969
NM_000441.1(SLC26A4):
5172
SLC26A4
[′GGAGAGCCTGGCCAAGTGCTGCAGGYAGCG

c.164 + 2T > C

GCCGCGCGGGCCTGCGTAGAG′]

1970
NM_000441.1(SLC26A4): c.2T >
−1
—
[′TCGCTGTCCTCTGGCTCGCAGGTCABGGCAG

C (p.Met1Thr)

CGCCAGGCGGCAGGTCGGAG′]

1971
NM_000441.1(SLC26A4)
5172
SLC26A4
[′AATGGAGTTCTCTCTATTATCTATGYAAGTG

c.765 + 2T > C

TTGCTTCTTGCTCCAGGGAT′]

1972
NM_000551.3(VHL): c.497T > C
7428
VHL
[′CTGAAAGAGCGATGCCTCCAGGTTGYCCGG

(p.Val166Ala)

AGCCTAGTCAAGCCTGAGAAT′]

1973
NM_001399.4(EDA): c.2T > C
1896
EDA
[′AGAGAGTGGGTGTCTCCGGAGGCCAYGGGC

(p.Met1Thr)

TACCCGGAGGTGGAGCGCAGG′]

1974
NM_001943.3(DSG2):
1829
DSG2
[′CTGTTGAAGAGTTGAGTGCAGCACGYAAGA

c.523 + 2T > C

GTCTTTTTTTTTTTTTTTAAT′]

1975
NM_004572.3(PKP2): c.2062T >
5318
PKP2
[′TTGCGGACACTTTTGGCGATCAAGGRCAGAT

C (p.Ser688Pro)

ACATCCTTATAACAATGGAA′]

1976
NM_005633.3(SOS1): c.1310T >
6654
SOS1
[′ATTGATGGTTGGGAGGGAAAAGACABTGGA

C (p.Ile437Thr)

CAGTGTTGTAATGAATTTATA′]

1977
NM_170707.3(LMNA): c.799T >
4000
LMNA
[′GTATAAGAAGGAGCTGGAGAAGACTYATTC

C (p.Tyr267His)

TGCCAAGGTGCTTGCTCTCGA′]

1978
NM_206933.2(USH2A):
7399
USH2A
[′TCTTGAAGATACAATTGTCTTAAACYGGAGA

c.10561T > C (p.Trp3521Arg)

AAACCTATACAATCAAATGG′]

1979
NM_206933.2(USH2A):
7399
USH2A
[′CGACACAACAAGCCAGCCATATAGAYGCCT

c.1606T > C (p.Cys536Arg)

CTGCTCCCAGGAGAGCTTCAC′]

1980
NM_206933.2(USH2A):
−1
—
[′GTCGAGGACGTACAACAGGAGCAGGYAAAT

c.5857 + 2T > C

ACTTATCTTCAAATGCATATG′]

1981
NM_000492.3(CFTR): c.1090T >
1080
CFTR
[′CTGGGCTGTACAAACATGGTATGACYCTCTT

C (p.Ser364Pro)

GGAGCAATAAACAAAATACA′]

1982
NM_000548.3(TSC2): c.5150T >
7249
TSC2
[′CCCTTCGTGGCCCGCCAGATGGCCCYGCACG

C (p.Leu1717Pro)

CAAATGTGAGTGGGGGTGGG′]

1983
NM_000548.3(TSC2): c.2410T >
7249
TSC2
[′CCTCATCCACCGCTGTGCCAGCCAGYGCGTC

C (p.Cys804Arg)

GTGGCCTTGTCCATCTGCAG′]

1984
NM_000548.3(TSC2): c.3106T >
7249
TSC2
[′GGACATGATGGCTCGATACGTCTTCYCCAAC

C (p.Ser1036Pro)

TTCACGGCTGTCCCGAAGAG′]

1985
NM_000212.2(ITGB3): c.2231T >
−1
—
[′GCCGCCCTGCTCATCTGGAAACTCCYCATCA

C (p.Leu744Pro)

CCATCCACGACCGAAAAGAA′]

1986
NM_183415.2(UBE3B):
89910
UBE3B
[′AGATGATCTGGGATGGAATTGTAGGYAAGA

c.1741 + 2T > C

GAAAAGGTGTCTGCTGTTGTT′]

1987
NM_005120.2(MED12):
9968
MED12
[′CCTTTTAGCTTGTAGTGAACAGGACYCTGAG

c.3493T > C (p.Ser1165Pro)

CCAGGGGCCCGGCTTACCTG′]

1988
NM_001033053.2(NLRP1):
22861
NLRP1
[′CTAGCCCTCCATACCTGGGAGCAGAYGGGG

c.230T > C (p.Met77Thr)

CTGAGGTCACTGTGCGCCCAA′]

1989
NM_025152.2(NUBPL):
80224
NUBPL
[′ATGCCTATATGAACTTTTCTGGTTCYAATGG

c.815 − 27T > C

ATGTCTGCTGGGCTCTTTTA′]

1990
NM_001288953.1(TTC7A):
57217
TTC7A
[′GCGTGGCAGGGCCTGGGCGAGGTGCYGCAG

c.2366T > C (p.Leu789Pro)

GCCCAGGGCCAGAACGAGGCT′]

1991
NM_014845.5(FIG4): c.524T > C
9896
FIG4
[′TACAGCTATGATTTGTCCCACTCACYTCAAT

(p.Leu175Pro)

ATAATCTCACTGTCTTGCGA′]

1992
NM_000059.3(BRCA2): c.2T > C
675
BRCA2
[′ATTGGAGGAATATCGTAGGTAAAAABGCCT

(p.Met1Thr)

ATTGGATCCAAAGAGAGGCCA′]

1993
NM_000059.3(BRCA2): c.316 + 2
675
BRCA2
[′TAGATAAATTCAAATTAGACTTAGGYAAGT

T > C

AATGCAATATGGTAGACTGGG′]

1994
NM_000059.3(BRCA2): c.67 + 2T
675
BRCA2
[′TTAAGACACGCTGCAACAAAGCAGGHATTG

> C

ACAAATTTTATATAACTTTAT′]

1995
NM_000059.3(BRCA2):
675
BRCA2
[′AGATGCCTAAGCCCAGAAAGGGTGCYTCTT

c.7958T > C (p.Leu2653Pro)

CAACTAAAATACAGGCAAGTT′]

1996
NM_000218.2(KCNQ1):
3784
KCNQ1
[′TGCTTCTCTGTCTTTGCCATCTCCTHCTTTGC

c.1016T > C (p.Phe339Ser)

GCTCCCAGCGGTAGGTGCC′]

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1045T > C (p.Ser349Pro)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1052T > C (p.Phe351Ser)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1058T> C (p.Leu353Pro)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1541T > C (p.Ile514Thr)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1661T > C (p.Val554Ala)

1997
NM_000218.2(KCNQ1):
3784
KCNQ1
[′CTTCTCTCCAGGCTGGACCAGTCCABTGGGA

c.1700T > C (p.Ile567Thr)

AGCCCTCACTGTTCATCTCC′]

NM_000218.2(KCNQ1): c.2T > C
3784
KCNQ1
[]

(p.Met1Thr)

NM_000218.2(KCNQ1): c.341T >
3784
KCNQ1
[]

C (p.Leul14Pro)

1998
NM_000218.2(KCNQ1): c.560T >
3784
KCNQ1
[′GGCTGCCGCAGCAAGTACGTGGGCCYCTGG

C (p.Leu187Pro)

GGGCGGCTGCGCTTTGCCCGG′]

NM_000218.2(KCNQ1): c.572T >
3784
KCNQ1
[]

C (p.Leu191Pro)

NM_000218.2(KCNQ1): c.716T >
3784
KCNQ1
[]

C (p.Leu239Pro)

NM_000218.2(KCNQ1): c.752T >
3784
KCNQ1
[]

C (p.Leu251Pro)

NM_000218.2(KCNQ1): c.797T >
3784
KCNQ1
[]

C (p.Leu266Pro)

NM_000218.2(KCNQ1): c.824T >
3784
KCNQ1
[]

C (p.Phe275Ser)

NM_000218.2(KCNQ1): c.910T >
3784
KCNQ1
[]

C (p.Trp304Arg)

NM_000218.2(KCNQ1): c.913T >
3784
KCNQ1
[]

C (p.Trp305Arg)

1999
NM_000492.3(CFTR): c.1021T >
1080
CFTR
[′CCTCCGGAAAATATTCACCACCATCYCATTC

C (p.Ser341Pro)

TGCATTGTTCTGCGCATGGC′]

2000
NM_000492.3(CFTR): c.1853T >
1080
CFTR
[′TTAAAGAAAGCTGACAAAATATTAAYTTTG

C (p.Ile618Thr)

CATGAAGGTAGCAGCTATTTT′]

2001
NM_000492.3(CFTR): c.2780T >
1080
CFTR
[′TACGTGGGAGTAGCCGACACTTTGCYTGCTA

C (p.Leu927Pro)

TGGGATTCTTCAGAGGTCTA′]

2002
NM_000492.3(CFTR): c.3230T >
1080
CFTR
[′GGACGGCAGCCTTACTTTGAAACTCYGTTCC

C (p.Leu1077Pro)

ACAAAGCTCTGAATTTACAT′]

2003
NM_007294.3(BRCA1): c.115T >
672
BRCA1
[′GATCAAGGAACCTGTCTCCACAAAGNGTGA

C (p.Cys39Arg)

CCACATATTTTGCAAGTAAGT′]

2004
NM_007294.3(BRCA1): c.190T >
672
BRCA1
[′GAAAGGGCCTTCACAGTGTCCTTTABGTAAG

C (p.Cys64Arg)

AATGATATAACCAAAAGGTA′]

2005
NM_007294.3(BRCA1):
672
BRCA1
[′ATGTAAGAATGATATAACCAAAAGGYATAT

c.212 + 2T > C

AATTTGGTAATGATGCTAGGT′]

2006
NM_007294.3(BRCA1): c.2T > C
672
BRCA1
[′TAAAGTTCATTGGAACAGAAAGAAABGGAT

(p.Met1Thr)

TTATCTGCTCTTCGCGTTGAA′]

2007
NM_007294.3(BRCA1):
672
BRCA1
[′CAGAACAAAGCACATCAGAAAAAGGBGTGT

c.4357 + 2T > C

ATTGTTGGCCAAACACTGATA′]

2008
NM_007294.3(BRCA1):
672
BRCA1
[′CTCTTCTTCCAGATCTTCAGGGGGCYAGAAA

c.5291T > C (p.Leu1764Pro)

TCTGTTGCTATGGGCCCTTC′]

2009
NM_007294.3(BRCA1): c.65T > C
672
BRCA1
[′GTCATTAATGCTATGCAGAAAATCTYAGAGT

(p.Leu22Ser)

GTCCCATCTGGTAAGTCAGC′]

2010
NM_005236.2(ERCC4): c.689T >
2072
ERCC4
[′ATGCTTGCTATACAGACTGCTATACYGGACA

C (p.Leu230Pro)

TTTTAAATGCATGTCTAAAG′]

2011
NM_005236.2(ERCC4): c.706T >
2072
ERCC4
[′TGCTATACTGGACATTTTAAATGCAYGTCTA

C (p.Cys236Arg)

AAGGAACTAAAATGCCATAA′]

2012
NM_000435.2(NOTCH3):
4854
NOTCH3
[′GGCGTGCTGGTGCTCACAGTGCTGCYGCCGC

c.4556T > C (p.Leu1519Pro)

CAGAGGAGCTACTGCGTTCC′]

2013
NM_153704.5(TMEM67):
91147
TMEM67
[′GGAAATTTTCTCAAGTGGCAAACTTYAGAA

c.1046T > C (p.Leu349Ser)

GGAGGTGTTTTACAGGTAAGC′]

2014
NM_001142519.1(FAM111A):
63901
FAM111A
[′GTCTAAAAAAGCAGAAAGTCCAGAGYATGT

c.1531T > C (p.Tyr511His)

CCATATGTATACTCAAAGAAG′]

2015
NM_014795.3(ZEB2): c.3211T >
9839
ZEB2
[′GCGCTTCTCACACTCGGGCTCGTACYCGCAG

C (p.Ser1071Pro)

CACATGAATCACAGGTATTC′]

2016
NM_001199107.1(TBC1D24):
57465
TBC1D24
[′CCCCTCTGCTACTTCGCCCGGGTCTYTGACG

c.686T > C (p.Phe229Ser)

TCTTCCTGGTGGAGGGCTAC′]

2017
NM_022114.3(PRDM16):
63976
PRDM16
[′GTGGGAGCCCTGAAGGAGAAGTACCYGCGG

c.2660T > C (p.Leu887Pro)

CCGTCCCCGCTGCTCTTCCAC′]

2018
NM_001130089.1(KARS):
3735
KARS
[′AGCTTCTGGGGGAAAGCTCATCTTCYATGAT

c.517T > C (p.Tyr173His)

CTTCGAGGAGAGGGGGTGAA′]

2019
NM_005689.2(ABCB6):
10058
ABCB6
[′CTCATCTTCTCCCACCTGCACGAGCYCTCAC

c.1067T > C (p.Leu356Pro)

TGCGCTGGCACCTGGGGCGC′]

2020
NM_001070.4(TUBG1):
7283
TUBG1
[′CCCCTGTTTTCTGCACACCCCAAGCYCTTCG

c.1160T > C (p.Leu387Pro)

AGAGAACCTGTCGCCAGTAT′]

2021
NM_001283009.1(RTEL1):
−1
—
[′CGGGCCCCTCTCAGCAGGCTGTGTGYGCCA

c.3730T > C (p.Cys1244Arg)

GGGCTGTGGGGCAGAGGACGT′]

2022
NM_001135021.1(ELMOD3):
84173
ELMOD3
[′ATCACCCACATTGCCATCCAGGCCTYGAGA

c.794T > C (p.Leu265Ser)

GAGGAGTGTCTCTCCAGGTGA′]

2023
NM_001382.3(DPAGT1):
1798
DPAGT1
[′CTACCATCTCTCCCCGCAGGAATCCYGTACT

c.503T> C (p.Leu168Pro)

ATGTCTACATGGGGCTGCTG′]

2024
m.10237T > C
4537
MT-ND3
[′CCATAAAATTCTTCTTAGTAGCTATYACCTT

CTTATTATTTGATCTAGAAA′]

2025
m.11253T > C
4538
MT-ND4
[′TCCCTTCCCCTACTCATCGCACTAAYTTACA

CTCACAACACCCTAGGCTCA′]

2026
m.12811T > C
4540
MT-ND5
[′ATCCTTCTTGCTCATCAGTTGATGAYACGCC

CGAGCAGATGCCAACACAGC′]

2027
m.14325T > C
4541
MT-ND6
[′ATTCAGCTTCCTACACTATTAAAGTYTACCA

CAACCACCACCCCATCATAC′]

2028
NM_000142.4(FGFR3):
2261
FGFR3
[′ACCCAGCAGTGGGGGCTCGCGGACGNGAAG

c.2419T > C (p.Ter807Arg)

GGCCACTGGTCCCCAACAATG′]

2029
NM_000370.3(TTPA): c.548T > C
7274
TTPA
[′GTAGCCAAGAAGATTGCTGCTGTACYTACG

(p.Leu183Pro)

GTAAATGTATATTTTAACTGT′]

2030
NM_000375.2(UROS): c.139T > C
7390
UROS
[′TGAGTTTTTGTCTCTTCCCAGTTTCYCTGAGA

(p.Ser47Pro)

AGGTAAGGCCTGTTGTGAC′]

2031
NM_001006657.1(WDR35):
57539
WDR35
[′TCTGGCACCATTCAGAGATACAGTCYACCTA

c.1592T > C (p.Leu531Pro)

ATGTTGGTTTGATTCAAAAA′]

2032
NM_001876.3(CPT1A):
1374
CPT1A
[′GCAGATGCGCCGATCGTGGCCCACCYTTGG

c.1451T > C (p.Leu484Pro)

GAGGTGAGTTTTCACACTTTT′]

2033
NM_004595.4(SMS): c.449T > C
6611
SMS
[′GACGAAGATTCACCTTATCAAAATAYAAAA

(p.Ile150Thr)

ATTCTACACTCGAAGCAGTTT′]

2034
NM_005211.3(CSF1R): c.2483T >
1436
CSF1R
[′AAGTGGATGGCCCCAGAGAGCATCTYTGAC

C (p.Phe828Ser)

TGTGTCTACACGGTTCAGAGC′]

2035
NM_170707.3(LMNA): c.644T >
4000
LMNA
[′TCCTTCCTCCAACCCTTCCAGGAGCYGCGTG

C (p.Leu215Pro)

AGACCAAGCGCCGTCATGAG′]

2036
NM_194248.2(OTOF): c.3413T >
9381
OTOF
[′CCACCCTCCAACCTCTCCCAGGTGCYGTTCT

C (p.Leu1138Pro)

GGGGCCTACGGGACCTAAAG′]

2037
NM_000540.2(RYR1): c.14762
6261
RYR1
[′TACAGGGTGGTCTTCGACATCACCTYCTTCT

> C (p.Phe4921Ser)

TCTTCGTCATCGTCATCCTG′]

2038
NM_000540.2(RYR1): c.7358T >
6261
RYR1
[′GCCGGCAAGGGTGAGGCCCTGCGGAYCCGC

C (p.Ile2453Thr)

GCCATCCTCCGCTCCCTTGTG′]

2039
NM_000540.2(RYR1):
6261
RYR1
[′GAAGTGTCAGCCGTGCTCTACTACCYGGACC

c.10817T> C (p.Leu3606Pro)

AGGTGGGTGGGGCCGGAGGG′]

2040
NM_000540.2(RYR1):
6261
RYR1
[′TTTTACACCCTGCGGTTCCTTGCCCYCTTCTT

c.13703T > C (p.Leu4568Pro)

GGCATTTGCCATCAACTTC′]

2041
NM_000540.2(RYR1):
6261
RYR1
[′CCCGCCCTGCGGTGTCTGAGCCTCCYGCATA

c. 13949T > C (p.Leu4650Pro)

CACTGGTGGCCTTTCTCTGC′]

2042
NM_000540.2(RYR1):
6261
RYR1
[′GTGTGCCCACAGTCCTTCCTGTACCYGGGCT

c.14378T > C (p.Leu4793Pro)

GGTATATGGTGATGTCCCTC′]

2043
NM_015896.3(ZMYND10):
51364
ZMYND10
[′CTCAGGGCTTAGCAGCAGGTTGTACRGGGC

7c.79T > C (p.Leu266Pro)

GATCCACACTTGCCCGTCCAA′]

2044
NM_018127.6(ELAC2): c.460T >
60528
ELAC2
[′AAAATACCTCGAAGCAATCAAAATAYTTTCT

C (p.Phe154Leu)

GGTCCATTGAAAGGAATAGA′]

2045
NM_199355.2(ADAMTS18):
170692
ADAMTS18
[′CCTGCGGGTCACCATCCTCACGTACYGTACA

c.605T > C (p.Leu202Pro)

AAAGGACAGCAGAGGAGAAG′]

2046
NM_023110.2(FGFR1): c.494T >
2260
FGFR1
[′TCCCCAGAAAAGATGGAAAAGAAATYGCAT

C (p.Leu165Ser)

GCAGTGCCGGCTGCCAAGACA′]

2047
NM_001059.2(TACR3): c.766T >
6870
TACR3
[′CCATATTATCGTCATTATACTGGTGYACTGT

C (p.Tyr256His)

TTCCCATTGCTCATCATGGG′]

2048
NM_002055.4(GFAP): c.1070T >
2670
GFAP
[′TACCAGGACCTGCTCAATGTCAAGCHGGCC

C (p.Leu357Pro)

CTGGACATCGAGATCGCCACC′]

2049
NM_002055.4(GFAP): c.1076T >
2670
GFAP
[′GACCTGCTCAATGTCAAGCTGGCCCYGGAC

C (p.Leu359Pro)

ATCGAGATCGCCACCTACAGG′]

2050
NM_002055.4(GFAP): c. 1096T >
2670
GFAP
[′GGCCCTGGACATCGAGATCGCCACCYACAG

C (p.Tyr366His)

GAAGCTGCTAGAGGGCGAGGA′]

2051
NM_002055.4(GFAP): c.221T > C
2670
GFAP
[′CGGGCCAGTGAGCGGGCAGAGATGAYGGAG

(p.Met74Thr)

CTCAATGACCGCTTTGCCAGC′]

2052
NM_002055.4(GFAP): c.247T > C
2670
GFAP
[′GGAGCTCAATGACCGCTTTGCCAGCYACATC

(p.Tyr83His)

GAGAAGGTTCGCTTCCTGGA′]

2053
NM_002055.4(GFAP): c.269T > C
2670
GFAP
[′AGCTACATCGAGAAGGTTCGCTTCCYGGAA

(p.Leu90Pro)

CAGCAAAACAAGGCGCTGGCT′]

2054
NM_002055.4(GFAP): c.290T > C
2670
GFAP
[′TTCCTGGAACAGCAAAACAAGGCGCYGGCT

(p.Leu97Pro)

GCTGAGCTGAACCAGCTGCGG′]

2055
NM_002055.4(GFAP): c.302T > C
2670
GFAP
[′CAAAACAAGGCGCTGGCTGCTGAGCYGAAC

(p.Leu101Pro)

CAGCTGCGGGCCAAGGAGCCC′]

2056
NM_002055.4(GFAP): c.704T > C
2670
GFAP
[′GCCAAGCCAGACCTCACCGCAGCCCYGAAA

(p.Leu235Pro)

GAGATCCGCACGCAGTATGAG′]

2057
NM_002055.4(GFAP): c.739T > C
2670
GFAP
[′CCGCACGCAGTATGAGGCAATGGCGYCCAG

(p.Ser247Pro)

CAACATGCATGAAGCCGAAGA′]

2058
NM_002055.4(GFAP): c.992T > C
2670
GFAP
[′AGTTATCAGGAGGCGCTGGCGCGGCYGGAG

(p.Leu331Pro)

GAAGAGGGGCAGAGCCTCAAG′]

2059
NM_005554.3(KRT6A):
3853
KRT6A
[′GAGATCGCCACCTACCGCAAGCTGCBGGAG

c.1406T > C (p.Leu469Pro)

GGTGAGGAGTGCAGGTGGGTA′]

2060
NM_005554.3(KRT6A): c.521T >
3853
KRT6A
[′CAGATCAAGACCCTCAACAACAAGTBTGCC

C (p.Phe174Ser)

TCCTTCATCGACAAGGTGAGC′]

2061
NM_153490.2(KRT13): c.332T >
3860
KRT13
[′AATGAGAAGATCACCATGCAGAACCYCAAC

C (p.Leu111Pro)

GACCGCCTGGCTTCCTACCTG′]

2062
NM_170707.3(LMNA): c.1619T >
4000
LMNA
[′CCATGTCCCCACCAGGAAGTGGCCAYGCGC

C (p.Met540Thr)

AAGCTGGTGCGCTCAGTGACT′]

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1117T > C (p.Ser373Pro)

2063
NM_000218.2(KCNQ1):
3784
KCNQ1
[′TCCCCCTGCCCGACCTCAGACCGCABGGAG

c.1135T > C (p.Trp379Arg)

GTGCTATGCTGCCGAGAACCC′]

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1165T> C (p.Ser389Pro)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1174T > C (p.Trp392Arg)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1550T > C (p.Ile517Thr)

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1696T > C (p.Ser566Pro)

NM_000218.2(KCNQ1):
−1
—
[]

c.1805T > C (p.Leu602Pro)

NM_000218.2(KCNQ1): c.401T >
3784
KCNQ1
[]

C (p.Leu134Pro)

2064
NM_000218.2(KCNQ1): c.550T >
3784
KCNQ1
[′CTGGTCCGCCGGCTGCCGCAGCAAGBACGT

C (p.Tyr184His)

GGGCCTCTGGGGGCGGCTGCG′]

NM_000218.2(KCNQ1): c.608T >
3784
KCNQ1
[]

C (p.Leu203Pro)

NM_000218.2(KCNQ1): c.625T >
3784
KCNQ1
[]

C (p.Ser209Pro)

NM_000218.2(KCNQ1): c.742T >
3784
KCNQ1
[]

C (p.Trp248Arg)

2065
NM_000218.2(KCNQ1): c.749T >
3784
KCNQ1
[′GACCGCCAGGGAGGCACCTGGAGGCHCCTG

C (p.Leu250Pro)

GGCTCCGTGGTCTTCATCCAC′]

NM_000218.2(KCNQ1): c.829T >
3784
KCNQ1
[]

C (p.Ser277Pro)

NM_000218.2(KCNQ1): c.832T >
3784
KCNQ1
[]

C (p.Tyr278His)

NM_000218.2(KCNQ1): c.845T >
3784
KCNQ1
[]

C (p.Leu282Pro)

NM_000218.2(KCNQ1): c.908T >
3784
KCNQ1
[]

C (p.Leu303Pro)

2066
NM_000238.3(KCNH2): c.122T >
3757
KCNH2
[′AACGCTCGGGTGGAGAACTGCGCCGBCATC

C (p. Val41Ala)

TACTGCAACGACGGCTTCTGC′]

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1238T > C (p.Leu413Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1279T > C (p.Tyr427His)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1387T > C (p.Phe463Leu)

NM_000238.3(KCNH2): c.160T >
3757
KCNH2
[]

C (p.Tyr54His)

2067
NM_000238.3(KCNH2):
3757
KCNH2
[′GAGTACGGCGCGGCCGTGCTGTTCTYGCTCA

c.1655T > C (p.Leu552Ser)

TGTGCACCTTTGCGCTCATC′]

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1691T > C (p.Leu564Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1700T > C (p.Ile567Thr)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1702T > C (p.Trp568Arg)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1705T > C (p.Tyr569His)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1736T > C (p.Met579Thr)

2068
NM_000238.3(KCNH2):
3757
KCNH2
[′TGGCTGCACAACCTGGGCGACCAGANAGGC

c.1778T > C (p.Ile593Thr)

AAACCCTACAACAGCAGCGGC′]

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1816T > C (p.Ser606Pro)

2069
NM_000238.3(KCNH2):
3757
KCNH2
[′CTTCAGCAGCCTCACCAGTGTGGGCHTCGGC

c.1879T > C (p.Phe627Leu)

AACGTCTCTCCCAACACCAA′]

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1889T > C (p.Val630Ala)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1945T > C (p.Ser649Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.1985T > C (p.Ile662Thr)

NM_000238.3(KCNH2): c.202T >
3757
KCNH2
[]

C (p.Phe68Leu)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.2033T > C (p.Leu678Pro)

NM_000238.3(KCNH2): c.206T >
3757
KCNH2
[]

C (p.Leu69Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.2078T > C (p.Leu693Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.2309T > C (p.Val770Ala)

2070
NM_000238.3(KCNH2):
3757
KCNH2
[′TGGCCTCCAGGGAAGAATGACATCTBTGGG

c.2414T > C (p.Phe805Ser)

GAGCCTCTGAACCTGTATGCA′]

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.2452T > C (p.Ser818Pro)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.2573T > C (p.Ile858Thr)

2071
NM_000238.3(KCNH2): c.257T >
3757
KCNH2
[′GCTGCCGCGCAGATCGCGCAGGCACBGCTG

C (p.Leu86Pro)

GGCGCCGAGGAGCGCAAAGTG′]

NM_000238.3(KCNH2): c.260T >
3757
KCNH2
[]

C (p.Leu87Pro)

NM_000238.3(KCNH2): c.287T >
3757
KCNH2
[]

C (p.Ile96Thr)

NM_000238.3(KCNH2):
3757
KCNH2
[]

c.3146T > C (p.Leu1049Pro)

NM_000238.3(KCNH2): c.322T >
3757
KCNH2
[]

C (p.Cys108Arg)

2072
NM_000238.3(KCNH2): c.371T >
3757
KCNH2
[′AAGAACGAGGATGGGGCTGTCATCABGTTC

C (p.Met124Thr)

ATCCTCAATTTCGAGGTGGTG′]

NM_000238.3(KCNH2): c.65T >
3757
KCNH2
[]

C (p.Phe22Ser)

NM_000238.3(KCNH2): c.86T >
3757
KCNH2
[]

C (p.Phe29Ser)

NM_000238.3(KCNH2): c.872T >
3757
KCNH2
[]

C (p.Met291Thr)

NM_000238.3(KCNH2): c.89T >
3757
KCNH2
[]

C (p.Ile30Thr)

2073
NM_000238.3(KCNH2): c.92T >
3757
KCNH2
[′GCCCCCCTAGGCCGTAAGTTCATCABCGCCA

C (p.Ile31Thr)

ACGCTCGGGTGGAGAACTGC′]

NM_000891.2(KCNJ2): c.301T >
3759
KCNJ2
[]

C (p.Cys101Arg)

NM_000891.2(KCNJ2): c.650T >
3759
KCNJ2
[]

C (p.Leu217Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.1187T > C (p. Val396Ala)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.1190T > C (p.Ile397Thr)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2018T > C (p.Leu673Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2516T > C (p.Leu839Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2551T > C (p.Phe851Leu)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2743T > C (p.Cys915Arg)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2783T > C (p.Leu928Pro)

NM_000335.4(SCN5A): c.278T >
6331
SCN5A
[]

C (p.Phe93Ser)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.2804T > C (p.Leu935Pro)

2074
NM_000335.4(SCN5A):
6331
SCN5A
[′CAAGCGGACCACCTGGGATTTCTGCYGTGGT

c.2944T > C (p.Cys982Arg)

CTCCTGCGGCAGCGGCCTCA′]

2075
NM_198056.2(SCN5A):
6331
SCN5A
[′TGCCGCCCAGGGCCAGCTGCCCAGCYGCAT

c.3010T > C (p.Cys1004Arg)

TGCCACCCCCTACTCCCCGCC′]

2076
NM_000335.4(SCN5A):
6331
SCN5A
[′TTGTCTGCAGGCCTTCGAGGACATCYACCTA

c.3679T > C (p.Tyr1227His)

GAGGAGCGGAAGACCATCAA′]

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.3713T > C (p.Leu1238Pro)

2077
NM_000335.4(SCN5A):
6331
SCN5A
[′TGCCGACAAGATGTTCACATATGTCYTCGTG

c.3745T > C (p.Phe1249Leu)

CTGGAGATGCTGCTCAAGTG′]

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.3929T > C (p.Leu1310Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4027T > C (p.Phe1343Leu)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4028T > C (p.Phe1343Ser)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4034T > C (p.Leu1345Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4046T > C (p.Ile1349Thr)

NM_000335.4(SCN5A): c.407T >
6331
SCN5A
[]

C (p.Leul36Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4340T > C (p.Ile1447Thr)

2078
NM_000335.4(SCN5A):
6331
SCN5A
[′TTTATTGGTGTCATCATTGACAACTBCAACC

c.4415T > C (p.Phe1472Ser)

AACAGAAGAAAAAGATACGT′]

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4453T> C (p.Phe1485Leu)

NM_198056.2(SCN5A):
6331
SCN5A
[]

c.4493T > C (p.Met1498Thr)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4742T> C (p.Leu1581Pro)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.4778T > C (p.Phe1593Ser)

2079
NM_000335.4(SCN5A):
6331
SCN5A
[′CGCACGCTGCTCTTTGCCCTCATGABGTCCC

c.4952T > C (p.Met1651Thr)

TGCCTGCCCTCTTCAACATC′]

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.5111T > C (p.Phe1704Ser)

NM_000335.4(SCN5A):
6331
SCN5A
[]

c.5179T > C (p.Cys1727Arg)

NM_000335.4(SCN5A): c.544T >
6331
SCN5A
[]

C (p.Cys182Arg)

2080
NM_000335.4(SCN5A): c.5471T
6331
SCN5A
[′TTTGCCGATGCCCTGTCTGAGCCACYCCGTA

> C (p.Leu1824Pro)

TCGCCAAGCCCAACCAGATA′]

2081
NM_198056.2(SCN5A):
6331
SCN5A
[′GAGATGGACGCCCTGAAGATCCAGAHGGAG

c.5624T > C (p.Met1875Thr)

GAGAAGTTCATGGCAGCCAAC′]

2082
NM_000335.4(SCN5A): c.635T >
6331
SCN5A
[′AGATACACAACTGAATTTGTGGACCHGGGC

C (p.Leu212Pro)

AATGTCTCAGCCTTACGCACC′]

NM_000335.4(SCN5A): c.689T >
6331
SCN5A
[]

C (p.Ile230Thr)

NM_198056.2(SCN5A): c.944T >
6331
SCN5A
[]

C (p.Leu315Pro)

2083
NM_177976.2(ARL6): c.272T > C
84100
ARL6
[′TTACACAGAGAAGGCCAAGCTATTAYTTTTG

(p.Ile91Thr)

TCATTGATAGTAGTGATAGA′]

2084
NM_000487.5(ARSA): c.899T > C
410
ARSA
[′TCCCGAGGCGGCTGCTCCGGTCTCTYGCGGT

(p.Leu300Ser)

GTGGAAAGGGAACGACCTAC′]

2085
NM_000267.3(NF1): c.1595T > C
4763
NF1
[′GAATTAATTACAGGGCTCGTCCAACYGGTCC

(p.Leu532Pro)

CTCAGTCACACATGCCAGAG′]

2086
NM_001042492.2(NF1):
4763
NF1
[′CTTCAGAAAAGAGTGATGGCACTGCBGAGG

c.2288T > C (p.Leu763Pro)

CGCATTGAGCATCCCACTGCA′]

2087
NM_004990.3(MARS): c.1108T >
4141
MARS
[′CCTCACCAGAATCACCCAGGACATTYTCCAG

C (p.Phe370Leu)

CAGTTGCTGAAACGAGGTTT′]

2088
NM_004990.3(MARS): c.1568T >
4141
MARS
[′TTCTATGTCTGGTTTGATGCCACTAYTGGCT

C (p.Ile523Thr)

ATCTGTCCATCACAGCCAAC′]

2089
NM_006920.4(SCN1A):
−1
—
[′GTTCATTGTGCTATTTACTGGAGAGYGTGTA

c.4729T > C (p.Cys1577Arg)

CTGAAACTCATCTCTCTACG′]

2090
NM_006920.4(SCN1A):
−1
—
[′TGAGACCTTTGGCAACAGCATGATCYGCCTA

c.5113T > C (p.Cys1705Arg)

TTCCAAATTACAACCTCTGC′]

2091
NM_006920.4(SCN1A): c.838T >
6323
SCN1A
[′CAACCTGAGGAATAAATGTATACAAYGGCC

C (p.Trp280Arg)

TCCCACCAATGCTTCCTTGGA′]

2092
NM_006920.4(SCN1A): c.269T >
6323
SCN1A
[′TGTTGTGTTCCTGTCTTACAGACTTYTATAGT

C (p.Phe90Ser)

ATTGAATAAAGGGAAGGCC′]

2093
NM_006920.4(SCN1A): c.272T >
6323
SCN1A
[′TGTGTTCCTGTCTTACAGACTTTTAYAGTATT

C (p.Ile91Thr)

GAATAAAGGGAAGGCCATC′]

2094
NM_006920.4(SCN1A):
−1
—
[′TATTTCACCAATGCCTGGTGTTGGCYGGACT

c.3827T > C (p.Leu1276Pro)

TCTTAATTGTTGATGTAGGT′]

2095
NM_006920.4(SCN1A):
−1
—
[′CCAAACAAACTCCAGCTCATTGCCAYGGATT

c.5522T > C (p.Met1841Thr)

TGCCCATGGTGAGTGGTGAC′]

2096
NM_006920.4(SCN1A): c.568T >
6323
SCN1A
[′AGATTTTACTTTCCTTCGGGATCCAYGGAAC

C (p.Trp190Arg)

TGGCTCGATTTCACTGTCAT′]

2097
NM_002608.2(PDGFB): c.356T >
5155
PDGFB
[′ATAGACCGCACCAACGCCAACTTCCYGGTG

C (p.Leu119Pro)

TGGCCGCCCTGTGTGGAGGTG′]

2098
NM_000833.4(GRIN2A): c.2T > C
2903
GRIN2A
[′TTGCAGGGACCGTCAGTGGCGACTAYGGGC

(p.Met1Thr)

AGAGTGGGCTATTGGACCCTG′]

2099
NM_002474.2(MYH11):
4629
MYH11
[′CTCCCCATCGCTGCACTTGGACTGCDGCTCC

c.3791T > C (p.Leu1264Pro)

TGCACCTGCGCCTCCAGCTT′]

2100
NM_014139.2(SCN11A):
11280
SCN11A
[′CTCAACCTCTTCATTGCCTTACTGCYCAATT

c.2432T > C (p.Leu811Pro)

CCTTTAGCAATGAGGAAAGA′]

2101
NM_006514.3(SCN10A):
6336
SCN10A
[′GGAGTCAGGGTTGCTGGGTTGAGGARGAGG

c.1661T > C (p.Leu554Pro)

GCTTCTAGGGAGGGGGCCTTG′]

2102
NM_000179.2(MSH6): c.1346T >
2956
MSH6
[′CTTATTGGAGTCAGTGAACTGGGGCYGGTAT

C (p.Leu449Pro)

TCATGAAAGGCAACTGGGCC′]

2103
NM_000179.2(MSH6):
2956
MSH6
[′GAATCAGTCACTACGATTATTTCGGYAACTA

c.4001 + 2T > C

ACTAACTATAATGGAATTAT′]

2104
NM_000249.3(MLH1): c.1745T >
4292
MLH1
[′GCTTCTTCCTAGGAGCCAGCACCGCYCTTTG

C (p.Leu582Pro)

ACCTTGCCATGCTTGCCTTA′]

2105
NM_000249.3(MLH1): c.2246T >
4292
MLH1
[′CTGCAGCTTGCTAACCTGCCTGATCHATACA

C (p.Leu749Pro)

AAGTCTTTGAGAGGTGTTAA′]

2106
NM_000249.3(MLH1): c.229T > C
4292
MLH1
[′ACAGAAAGAAGATCTGGATATTGTAYGTGA

(p.Cys77Arg)

AAGGTTCACTACTAGTAAACT′]

2107
NM_000249.3(MLH1):
4292
MLH1
[′GGCAATCAAGGGACCCAGATCACGGYAAGA

c.453 + 2T > C

ATGGTACATGGGAGAGTAAAT′]

2108
NM_000249.3(MLH1): c.739T > C
4292
MLH1
[′AGCCTTCAAAATGAATGGTTACATABCCAAT

(p.Ser247Pro)

GCAAACTACTCAGTGAAGAA′]

2109
NM_000249.3(MLH1):
4292
MLH1
[′GCATCTTCTTACTCTTCATCAACCGHAAGTT

c.790 + 2T > C

AAAAAGAACCACATGGGAAA′]

2110
NM_000251.2(MSH2): c.1319T >
4436
MSH2
[′TTGTTGGCAGTTTTTGTGACTCCTCYTACTG

C (p.Leu440Pro)

ATCTTCGTTCTGACTTCTCC′]

2111
NM_000251.2(MSH2):
4436
MSH2
[′AACAGATGTTCCACATCATTACTGGYAAAA

c.2005 + 2T > C

AACCTGGTTTTTGGGCTTTGT′]

2112
NM_000251.2(MSH2): c.2089T >
4436
MSH2
[′GGCCCAAATTGGGTGTTTTGTGCCAYGTGAG

C (p.Cys697Arg)

TCAGCAGAAGTGTCCATTGT′]

2113
NM_000251.2(MSH2): c.560T > C
4436
MSH2
[′CCTGATAATGATCAGTTCTCCAATCBTGAGG

(p.Leu187Pro)

CTCTCCTCATCCAGATTGGA′]

2114
NM_000251.2(MSH2): c.595T > C
4436
MSH2
[′CCTCATCCAGATTGGACCAAAGGAAYGTGT

(p.Cys199Arg)

TTTACCCGGAGGAGAGACTGC′]

2115
NM_000251.2(MSH2): c.929T > C
4436
MSH2
[′TTGGATATTGCAGCAGTCAGAGCCCBTAACC

(p.Leu310Pro)

TTTTTCAGGTAAAAAAAAAA′]

2116
NM_007294.3(BRCA1):
672
BRCA1
[′AAAGTGTGACCACATATTTTGCAAGBAAGTT

c.134 + 2T > C

TGAATGTGTTATGTGGCTCC′]

2117
NM_001194998.1(CEP152):
22995
CEP152
[′TATGAGGAAGACATCCTGACTGTACYTGGG

c.3149T > C (p.Leu1050Pro)

GTTCTTTTAAGTGATACCCAA′]

2118
NM_001271723.1(FBXO38):
81545
FBXO38
[′AGGGGTGAATGTTCCTGAAATTCCTYGTATC

c.616T > C (p.Cys206Arg)

CCAATGCTAAGGCACCTTTA′]

2119
NM_014495.3(ANGPTL3):
−1
—
[′ACATCGAATAGATGGATCACAAAACYTCAA

c.883T > C (p.Phe295Leu)

TGAAACGTGGGAGAACTACAA′]

2120
NM_003184.3(TAF2): c.1945T >
6873
TAF2
[′CTCTCATAGCGGAGCTGATACTGCCRCATAA

C (p.Trp649Arg)

AATCAGCTTGCTCAAATTCT′]

2121
NM_000016.5(ACADM):
34
ACADM
[′TTCTTCTAGTATCCAGTCCCCCTAAYTAGAA

c.233T > C (p.Ile78Thr)

GAGCCTGGGAACTTGGTTTA′]

2122
NM_000019.3(ACAT1):
38
ACAT1
[′TTCCTGTCACAGTTACAGTAAAAGGYAGAG

c.730 + 2T > C

ATAATGTTCCAAAAAGGATGA′]

2123
NM_000143.3(FH): c.1255T > C
2271
FH
[′GAAGCATCCCCCAGCAGCCTGGCTGRGTGT

(p.Ser419Pro)

AACACATTTTTAATCTTTGAG′]

2124
NM_000169.2(GLA): c.899T > C
−1
—
[′GCTCCTTTATTCATGTCTAATGACCYCCGAC

(p.Leu300Pro)

ACATCAGCCCTCAAGCCAAA′]

2125
NM_000202.6(IDS): c.587T > C
3423
IDS
[′GTGCTGGATGTTCCCGAGGGCACCTYGCCTG

(p.Leu196Ser)

ACAAACAGAGCACTGAGCAA′]

2126
NM_000252.2(MTM1): c.688T >
4534
MTM1
[′TCTGACTTAACCATAGGTGCTGTCAYGGATT

C (p.Trp230Arg)

CATCCAGAAAATAAGACGGT′]

2127
NM_000277.1(PAH): c.638T > C
5053
PAH
[′GAGTACAATCACATTTTTCCACTTCYTGAAA

(p.Leu213Pro)

AGTACTGTGGCTTCCATGAA′]

2128
NM_000404.2(GLB1):
2720
GLB1
[′TTCTTCTCCGCTCCTCCGACCCAGGYAGGTT

c.457 + 2T > C

GTTACAGATGTCTTGAGAAG′]

2129
NM_000528.3(MAN2B1):
4125
MAN2B1
[′AGAGATGGCTCGCTGGAGCTCATGGYGAGT

c.2436+ 2T > C

GGGTCAGAGCCCCATCCGAGC′]

2130
NM_000531.5(OTC):
5009
OTC
[′CTGGCTGATTACCTCACGCTCCAGGHTGGTT

c.540 + 2T > C

TATTTATTTGTCTTACAAAA′]

2131
NM_001005741.2(GBA):
2629
GBA
[′TTCACCGCTCCATTGGTCTTGAGCCRAGTGG

c.667T > C (p.Trp223Arg)

GTGATGTCCAGGGGCTGGCA′]

2132
NM_000402.4(G6PD): c.473T > C
2539
G6PD
[′CGCCTCAACAGCCACATGAATGCCCYCCAC

(p.Leu158Pro)

CTGGGGTCACAGGCCAACCGC′]

2133
NM_000402.4(G6PD): c.188T > C
−1
—
[′CACCGATGCACCCATGATGATGAATRTGTGT

(p.Ile63Thr)

GTATCCGACTGATGGAAGGC′]

2134
NM_006920.4(SCN1A):
−1
—
[′GGGTATCTCTCTTTGCTTCAAGTTGYAAGTG

c.4251 + 2T > C

AACACTATTTTCTCTGAATA′]

2135
NM_002225.3(IVD):
3712
IVD
[′CAGAAAGAGAAGTATCTCCCGAAGGYGAGG

c.465 + 2T > C

AAATGGAAATGTAATACACGC′]

2136
NM_003494.3(DYSF):
8291
DYSF
[′GAGGTCAGCTTTGCGGGGAAAATGGYAAGG

c.1284 + 2T > C

AGCAAGGGAGCAGGAGGGTTC′]

2137
NM_004006.2(DMD):
1756
DMD
[′CCCTGGTGGAACAGATGGTGAATGGYAATT

c.2380 + 2T > C

ACACGAGTTGATTTAGATAAT′]

2138
NM_012463.3(ATP6V0A2):
23545
ATP6V0A2
[′ACCCGCATCCAGGATCTCTACACTGYGAGTA

5c.82 + 2T > C

AGCTGGAAGTGGATTGCCTC′]

2139
NM_014795.3(ZEB2):
9839
ZEB2
[′AAGCCAATCCCAGGAGGAAAAACGGYAAG

c.73 + 2T >C

AAGCAGCCCGAACCAAACTTTT′]

2140
NM_016725.2(FOLR1):
2348
FOLR1
[′ACAAGGGCTGGAACTGGACTTCAGGYGAGG

c.493 + 2T > C

GCTGGGGTGGGCAGGAATGGA′]

2141
NM_000056.3(BCKDHB):
594
BCKDHB
[′CCTGTTCTGTATTTAGCGGAAGAAGYCCCTA

c.752T > C (p. Val251Ala)

TAGAACCATACAACATCCCA′]

2142
NM_175053.3(KRT74): c.821T >
121391
KRT74
[′TACTGCATCATACAGACACTTGAGGRACTTG

C (p.Phe274Ser)

ATTTCTTTGTCCAGTGAGTC′]

2143
NM_003764.3(STX11): c.173T >
8676
STX11
[′GACATTCAGGATGAAAACCAGCTGCYGGTG

C (p.Leu58Pro)

GCCGACGTGAAGCGGCTGGGA′]

2144
NM_001044.4(SLC6A3):
6531
SLC6A3
[′CTCTGCAGACGTGGCGTGCTGCACCYCCACC

c.671T > C (p.Leu224Pro)

AGAGCCATGGCATCGACGAC′]

2145
NM_015662.2(IFT172):
−1
—
[′CTGATGAATTTCAGCACGTCCTGGCRCACTG

c.5179T > C (p.Cys1727Arg)

GGCTGTGGGAGGTCTGTGAG′]

2146
NM_015662.2(IFT172):
26160
IFT172
[′GCGCGTGGCATAGTAATGAGCGATCRGCAG

c.4607T > C (p.Leu1536Pro)

CATCGTCTTGAACTCCTCATG′]

2147
NM_014754.2(PTDSS1):
9791
PTDSS1
[′ACCGGGAAGATCAAGAGAGCTGTTCYGCAG

c.794T > C (p.Leu265Pro)

TTCACTCCTGCTAGCTGGACC′]

2148
NM_014714.3(IFT140):
9742
IFT140
[′GGACCCCAAGGAGTCCATCAAGCAGYGTGA

c.4078T > C (p.Cys1360Arg)

GCTGCTCCTGGAGGAACCAGA′]

2149
NM_000531.5(OTC):
5009
OTC
[′GAAAACAGAAAGTGGACAATCATGGYAAGC

c.1005 + 2T > C

AAGAAACAAGGAATGGAGGAT′]

2150
NM_000531.5(OTC): c.1018T > C
5009
OTC
[′GTTGTGTCATCAGGCTGTCATGGTGYCCCTG

(p.Ser340Pro)

CTGACAGATTACTCACCTCA′]

2151
NM_000531.5(OTC): c.1022T > C
5009
OTC
[′TGTCATCAGGCTGTCATGGTGTCCCYGCTGA

(p.Leu341Pro)

CAGATTACTCACCTCAGCTC′]

2152
NM_000531.5(OTC): c.1033T > C
5009
OTC
[′TGTCATGGTGTCCCTGCTGACAGATBACTCA

(p.Tyr345His)

CCTCAGCTCCAGAAGCCTAA′]

2153
NM_000531.5(OTC): c.143T > C
5009
OTC
[′CGTGACCTTCTCACTCTAAAAAACTYTACCG

(p.Phe48Ser)

GAGAAGAAATTAAATATATG′]

2154
NM_000531.5(OTC): c.158T > C
5009
OTC
[′CTAAAAAACTTTACCGGAGAAGAAABTAAA

(p.Ile53Thr)

TATATGCTATGGCTATCAGCA′]

2155
NM_000531.5(OTC): c.167T > C
5009
OTC
[′TTTACCGGAGAAGAAATTAAATATAYGCTA

(p.Met56Thr)

TGGCTATCAGCAGATCTGAAA′]

2156
NM_000531.5(OTC): c.188T > C
5009
OTC
[′TATATGCTATGGCTATCAGCAGATCYGAAAT

(p.Leu63Pro)

TTAGGATAAAACAGAAAGGA′]

2157
NM_000531.5(OTC): c.227T > C
5009
OTC
[′GTCCTTGATTTATAGTATTTGCCTTYATTGCA

(p.Leu76Ser)

AGGGAAGTCCTTAGGCATG′]

2158
NM_000531.5(OTC): c.284T > C
5009
OTC
[′GAGAAAAGAAGTACTCGAACAAGATYGTCT

(p.Leu95Ser)

ACAGAAACAGGTAAGTCCACT′]

2159
NM_000531.5(OTC): c.2T > C
5009
OTC
[′CGTCCTTTACACAATTAAAAGAAGAYGCTGT

(p.Met1Thr)

TTAATCTGAGGATCCTGTTA′]

2160
NM_000531.5(OTC):
5009
OTC
[′TGAAAGTCTCACGGACACGGCCCGGYTTGT

c.386 + 2T > C

AAATATTTTCTTCTCTCCAAA′]

2161
NM_000531.5(OTC): c.392T > C
5009
OTC
[′TTTTTCTTGGTTTGCCACAGTGTATYGTCTAG

(p.Leul31Ser)

CATGGCAGATGCAGTATTG′]

2162
NM_000531.5(OTC): c.394T > C
5009
OTC
[′TTTCTTGGTTTGCCACAGTGTATTGYCTAGC

(p.Ser132Pro)

ATGGCAGATGCAGTATTGGC′]

2163
NM_000531.5(OTC): c.416T > C
5009
OTC
[′TTGTCTAGCATGGCAGATGCAGTATYGGCTC

(p.Leu139Ser)

GAGTGTATAAACAATCAGAT′]

2164
NM_000531.5(OTC): c.443T > C
5009
OTC
[′GCTCGAGTGTATAAACAATCAGATTBGGAC

(p.Leu148Ser)

ACCCTGGCTAAAGAAGCATCC′]

2165
NM_000531.5(OTC): c.476T > C
5009
OTC
[′CTGGCTAAAGAAGCATCCATCCCAAYTATC

(p.Ile159Thr)

AATGGGCTGTCAGATTTGTAC′]

2166
NM_000531.5(OTC): c.479T > C
5009
OTC
[′GCTAAAGAAGCATCCATCCCAATTANCAAT

(p.Ile160Thr)

GGGCTGTCAGATTTGTACCAT′]

2167
NM_000531.5(OTC): c.490T > C
5009
OTC
[′ATCCATCCCAATTATCAATGGGCTGYCAGAT

(p.Ser164Pro)

TTGTACCATCCTATCCAGAT′]

2168
NM_000531.5(OTC): c.526T > C
5009
OTC
[′CCATCCTATCCAGATCCTGGCTGATYACCTC

(p.Tyr176His)

ACGCTCCAGGTTGGTTTATT′]

2169
NM_000531.5(OTC): c.536T > C
5009
OTC
[′CAGATCCTGGCTGATTACCTCACGCYCCAGG

(p.Leul79Pro)

TTGGTTTATTTATTTGTCTT′]

2170
NM_000531.5(OTC): c.577T > C
5009
OTC
[′CTCTCTGAAAGGTCTTACCCTCAGCBGGATC

(p.Trp193Arg)

GGGGATGGGAACAATATCCT′]

2171
NM_000531.5(OTC): c.602T > C
5009
OTC
[′TGGATCGGGGATGGGAACAATATCCYGCAC

(p.Leu201Pro)

TCCATCATGATGAGCGCAGCG′]

2172
NM_000531.5(OTC):
5009
OTC
[′CACCTTCAGGCAGCTACTCCAAAGGYAGGG

c.663 + 2T > C

AAACTTTTTGCCTTGAAACTA′]

2173
NM_000531.5(OTC): c.779T > C
5009
OTC
[′GAAGCAGCGCATGGAGGCAATGTATYAATT

(p.Leu260Ser)

ACAGACACTTGGATAAGCATG′]

2174
NM_000531.5(OTC): c.793T > C
5009
OTC
[′AGGCAATGTATTAATTACAGACACTYGGAT

(p.Trp265Arg)

AAGCATGGGACAAGAAGAGGA′]

2175
NM_000531.5(OTC): c.803T > C
5009
OTC
[′TTAATTACAGACACTTGGATAAGCAYGGGA

(p.Met268Thr)

CAAGAAGAGGAGAAGAAAAAG′]

2176
NM_000531.5(OTC): c.907T > C
5009
OTC
[′TGCCTCTGACTGGACATTTTTACACBGCTTG

(p.Cys303Arg)

CCCAGAAAGCCAGAAGAAGT′]

2177
NM_000531.5(OTC): c.947T > C
5009
OTC
[′CCAGAAGAAGTGGATGATGAAGTCTYTTAT

(p.Phe316Ser)

TCTCCTCGATCACTAGTGTTC′]

2178
NM_000322.4(PRPH2): c.637T >
5961
PRPH2
[′CCTGGTGGACGGCGTCCCTTTCAGCYGCTGC

C (p.Cys213Arg)

AATCCTAGCTCGCCACGGCC′]

2179
NM_000322.4(PRPH2): c.736T >
5961
PRPH2
[′CCACCAGACGGAGGAGCTCAACCTGYGGGT

C (p.Trp246Arg)

GCGTGGCTGCAGGGCTGCCCT′]

NM_017415.2(KLHL3):
26249
KLHL3
[]

c.1160T > C (p.Leu387Pro)

NM_017415.2(KLHL3):
26249
KLHL3
[]

c.1280T > C (p.Met427Thr)

2180
NM_003859.1(DPM1): c.742T > C
−1
—
[′AGAGTCAATAATCCTTTCAAGAAAGRTACTA

(p.Ser248Pro)

TTTCATTTCCTCCCAACTTG′]

2181
NM_004826.3(ECEL1):
9427
ECEL1
[′GGGTTCATGGGTGAGTCCTTGGGACRGTGG

c.2278T > C (p.Cys760Arg)

AAAGCCCGGCCAAACTCCTCA′]

2182
NM_014908.3(DOLK): c.2T > C
22845
DOLK
[′GGCCGGAGATGGGCACTCTCGGGTCRTATCT

(p.Met1Thr)

CTAGACCTGGGGCTTCACGG′]

2183
NM_000404.2(GLB1): c.922T > C
2720
GLB1
[′TCTTTTGTTTCCTTGTAGGTACATGYTTATAG

(p.Phe308Leu)

GTGGGACCAATTTTGCCTA′]

2184
NM_012434.4(SLC17A5):
26503
SLC17A5
[′TTAGGAGTTGGACCACTCATTGTACYCAGAG

c.500T > C (p.Leu167Pro)

CACTAGAAGGACTAGGAGAG′]

2185
NM_000211.4(ITGB2):
3689
ITGB2
[′CCCCTCACCCTGTGGCAAGTACATGYGAGTG

c.1877 + 2T > C

CAGGCGGAGCAGGCAGGGCG′]

2186
NM_006702.4(PNPLA6):
10908
PNPLA6
[′ACCTCCATGTTCACTGGGTCTGCCTYTAACC

c.3053T > C (p.Phe1018Ser)

GCAGCATCCATCGGGTCTTC′]

2187
NM_176787.4(PIGN): c.808T > C
23556
PIGN
[′TCTGAAGGATGACCAGCCCCATGGGRACCT

(p.Ser270Pro)

ACAAATAAGATATAAAGAATA′]

2188
NM_001165899.1(PDE4D):
5144
PDE4D
[′CCATGTCTCCCAGAGGGGATGAACARTATA

c.1850T > C (p.Ile617Thr)

GTCTATGAAGCCCACCTAGTT′]

2189
NM_005017.3(PCYT1A):
5130
PCYT1A
[′CCTTCTGTCCTCTGTGTTGGAGCAARCATGC

c.571T > C (p.Phe191Leu)

CTAACTCAGAAACACATACA′]

2190
NM_000090.3(COL3A1):
1281
COL3A1
[′CAGGACTTCCTGGGGCTGCAGTGAGHATAG

c.951 + 6T > C

CTGCTAACATCACACAATTAC′]

(p.Gly300_Ala317del)

2191
NM_000090.3(COL3A1):
1281
COL3A1
[′GCACCTGGAGCTCCAGGAGGCAAGGYAGTA

c.2022 + 2T > C

TTTCAATTTATTCTCTACCTT′]

(p.Gly660_Lys674del)

2192
NM_000090.3(COL3A1):
1281
COL3A1
[′CGGCCAGGACTTCCTGGGGCTGCAGHGAGT

c.951 + 2T > C

ATAGCTGCTAACATCACACAA′]

(p.Gly300_Ala317del)

2193
NM_000090.3(COL3A1):
1281
COL3A1
[′CGAGATGGATCTCCTGGTGGCAAGGBATAA

c.3093 + 2T > C

TAAACACATGTGCAATTGATT′]

(p.Gly1014_Lys1031del)

2194
NM_000090.3(COL3A1):
1281
COL3A1
[′CCAGCTGGCCAGCCTGGAGATAAGGYAACC

c.2337 + 2T > C

CTTAATACTACCTGGATATAA′]

(p.Gly762_Lys779del)

2195
NM_000090.3(COL3A1):
1281
COL3A1
[′TTCCCCGGTCCTAAAGGAAATGATGBGAGTT

c.1761 + 2T > C

CCTTCATTAATTTCTTCAAT′]

(p.Gly555_Asp587del)

2196
NM_000090.3(COL3A1):
1281
COL3A1
[′CTGGTGAACCTGGAAGAGATGTGAGYAGCA

c.3039 + 6T > C

GTTTTTATTCAACCAGCCAGG′]

(p.Asp1013_

Gly1014insVSSSFYSTSQ)

2197
NM_000090.3(COL3A1): c.4399
1281
COL3A1
[′GGACGTTGGCCCTGTTTGCTTTTTAYAAACC

T > C (p.Ter1467Gln)

AAACTCTATCTGAAATCCCA′]

2198
NM_000090.3(COL3A1):
1281
COL3A1
[′CCCCCTGGAGGTTCTGGACCTGCTGYAAGTT

c.2553 + 2T > C

CCTTCCTCTTTCTCTGTCTA′]

(p.Gly816_Ala851del)

2199
NM_001278503.1(STT3A):
3703
STT3A
[′TATACTCCAACTGGGGAGTTCCGTGYGGACC

c.1877T > C (p.Val626Ala)

GTGAAGGTTCTCCAGTGCTG′]

2200
NM_000277.1(PAH): c.691T > C
5053
PAH
[′TAACATTCCCCAGCTGGAAGACGTTYCTCAG

(p.Ser231Pro)

TTCCTGCAGAGTAAGTCCAC′]

2201
NM_007294.3(BRCA1):
672
BRCA1
[′GGACAGAGGACAATGGCTTCCATGGBAAGG

c.5467 + 2T > C

TGCCTGCATGTACCTGTGCTA′]

2202
NM_020347.3(LZTFL1):
54585
LZTFL1
[′ATACCACTTCTCAGCTTGTGCAAACRGCTGT

c.260T > C (p.Leu87Pro)

CGCAGAAGTAACACATTGGT′]

2203
NM_016381.5(TREX1): c.530T >
11277
TREX1
[′CGCCAGCCACAGCCCTGGTGCCTGGYGGCA

C (p.Val177Ala)

CACAATGGTGACCGCTACGAC′]

2204
NM_015474.3(SAMHD1):
25939
SAMHD1
[′TTTGTGTTGATAAGCTCTACGGTGTRAAGAG

c.1106T > C (p.Leu369Ser)

TTGCGAGTGTGGAACATGTC′]

2205
NM_005654.5(NR2F1): c.755T >
7025
NR2F1
[′CAGATCACCGACCAGGTGTCCCTGCYACGC

C (p.Leu252Pro)

CTCACCTGGAGCGAGCTGTTC′]

2206
NM_003638.2(ITGA8):
8516
ITGA8
[′TGCCTATATATATTTAAAGATACTCRCTACT

c.2982 + 2T > C

ATGCTTCCTTCTGGGAGTTT′]

2207
NM_000321.2(RB1):
5925
RB1
[′AGGATCAGATGAAGCAGATGGAAGGYAGG

c.2663 + 2T > C

AACCAGTTTTGAATGTTTTCCA′]

2208
NM_000321.2(RB1): c. 1472T > C
5925
RB1
[′CATATGTCTTTATTGGCGTGCGCTCYTGAGG

(p.Leu491Pro)

TTGTAATGGCCACATATAGC′]

2209
NM_015884.3(MBTPS2):
51360
MBTPS2
[′GCTATTGTTAATGCAGTACCCTGCTYTGCTT

c.1391T > C (p.Phe464Ser)

TGGATGGACAATGGATTCTA′]

2210
NM_001739.1(CA5A): c.697T > C
763
CA5A
[′TCGGTCAGCGGCGGGGTGGTGAGCGRGCCC

(p.Ser233Pro)

GCGTAGGTCCAGTAATCCCAG′]

2211
NM_005051.2(QARS): c.169T > C
5859
QARS
[′TCCCTGAGTCGGGAGGCCAAGCCATRTAAC

(p.Tyr57His)

AGGATCCCGGTAGCTTTGTCA′]

2212
NM_005356.4(LCK): c. 1022T > C
3932
LCK
[′GGCATCAAGTTGACCATCAACAAACYCCTG

(p.Leu341Pro)

GACATGGCAGCCCAAGTAAGG′]

2213
NM_021803.3(IL21): c. 146T > C
59067
IL21
[′TACCAAGTCATTCACATAATTTTTCRGCTGA

(p.Leu49Pro)

TCAACAATATCTATAAGTTG′]

2214
NM_005861.3(STUB1): c.719T >
−1
—
[′TGTGGCAAGATCAGCTTTGAGCTGAYGCGG

C (p.Met240Thr)

GAGCCGTGCATCACGCCCAGT′]

2215
NM_032575.2(GLIS2): c.523T > C
84662
GLIS2
[′TCAGAACACTTCCCATCCTCCGCAGYGTAAC

(p.Cys175Arg)

CAGCTCTTTGAGCTCCTGCA′]

2216
NM_001101.3(ACTB): c.224T > C
60
ACTB
[′CTGAAGTACCCCATCGAGCACGGCAYCGTC

(p.Ile75Thr)

ACCAACTGGGACGACATGGAG′]

2217
NM_001101.3(ACTB): c.356T > C
60
ACTB
[′AACCCCAAGGCCAACCGCGAGAAGAYGACC

(p.Met119Thr)

CAGGTGAGTGGCCCGCTACCT′]

2218
NM_003401.3(XRCC4): c.127T >
7518
XRCC4
[′TACACTTACTGATGGTCATTCAGCAYGGACT

C (p.Trp43Arg)

GGGACAGGTAATACTAAAAA′]

2219
NM_000051.3(ATM):
472
ATM
[′CTGGAGAGAGCCAAAGTACCATAGGYAAAT

c.2638 + 2T > C

ACATATTTACTACTTGGGATT′]

2220
NM_000535.5(PMS2): c.2T > C
5395
PMS2
[′CGAGGCGGATCGGGTGTTGCATCCAHGGAG

(p.Met1Thr)

CGAGCTGAGAGCTCGAGGTGA′]

2221
NM_015713.4(RRM2B): c.190T >
50484
RRM2B
[′ATGCCACGTACCTCTTCTGCTGTCCRGAAGG

C (p.Trp64Arg)

AAGCCTGTGCCTGTTTATAC′]

2222
NM_015713.4(RRM2B): c.368T >
50484
RRM2B
[′CTCGATGAGAATTTGAAAGCCATAGRAACA

C (p.Phe123Ser)

GCGAGCCTCTGGAACCTGCAC′]

2223
NM_003122.4(SPINK1):
6690
SPINK1
[′TTAAAAGAAACTCAAGTTTGTACTCRCCGAT

c.194 + 2T > C

TTTCAAAACATAACACGCAT′]

2224
NM_003122.4(SPINK1): c.160T >
6690
SPINK1
[′AAACATAACACGCATTCATTGGGATRAGTAT

C (p.Tyr54His)

TTCCATCAGTCCCACAGACA′]

NM_000219.5(KCNE1): c.158T >
3753
KCNE1
[]

C (p.Phe53Ser)

2225
NM_000219.5(KCNE1): c.176T >
3753
KCNE1
[′GCGGATGTAGCTCAGCATGATGCCCRGGGT

C (p.Leu59Pro)

GAAGAAGCCGAAGAATCCCAG′]

NM_000219.5(KCNE1): c.259T >
3753
KCNE1
[]

C (p.Trp87Arg)

2226
NM_017890.4(VPS13B):
157680
VPS13B
[′CGTTTGTAAAGCACATCTCCAAAGGYAGCG

c.11119 + 2T > C

GGTTCCGTTCCTTGTAATAAT′]

2227
NM_005026.3(PIK3CD):
5293
PIK3CD
[′CACCTGCCCTGTCCTTCTGCAGGACYGCCCC

c.1246T > C (p.Cys416Arg)

ATTGCCTGGGCCAACCTCAT′]

2228
NM_000271.4(NPC1): c.2054T >
4864
NPC1
[′TACATTGGGTTGCCCTTGACCCTCAYTGTGA

C (p.Ile685Thr)

TTGAAGTCATCCCGTTCCTG′]

2229
NM_002633.2(PGM1): c.1547T >
5236
PGM1
[′GGGAGTGCCGGGGCCACCATTCGGCYGTAC

C (p.Leu516Pro)

ATCGATAGCTATGAGAAGGAC′]

2230
NM_015599.2(PGM3): c.248T > C
5238
PGM3
[′TTGGTTGATCCTTTGGGTGAAATGTYGGCAC

(p.Leu83Ser)

CATCCTGGGAGGAACATGCC′]

2231
NM_002136.2(HNRNPA1):
3178
HNRNPA1
[′GAATTACAACAATCAGTCTTCAAATBTTGGA

c.817T > C (p.Phe273Leu)

CCCATGAAGGGAGGAAATTT′]

2232
NM_002136.2(HNRNPA1):
3178
HNRNPA1
[′TTTTGGACCCATGAAGGGAGGAAATYTTGG

c.841T > C (p.Phe281Leu)

AGGCAGAAGCTCTGGCCCCTA′]

2233
NM_001159287.1(TPI1):
7167
TPI1
[′GGTGGTGCTTCCCTCAAGCCCGAATYCGTGG

c.833T > C (p.Phe278Ser)

ACATCATCAATGCCAAACAA′]

2234
NM_130838.1(UBE3A): c.2T > C
7337
UBE3A
[′TCTGACGACATTGAAGCTAGCCGAAYGTAA

(p.Met1Thr)

GTGTAACTTGGTTGAGACTGT′]

2235
NM_130838.1(UBE3A): c.710T >
7337
UBE3A
[′ATTGAAACTGCCTTTCTCAATGCACHTGTAT

C (p.Leu237Pro)

ATTTGTCACCTAACGTGGAA′]

2236
NM_000414.3(HSD17B4):
3295
HSD17B4
[′AGTGGAGACTGGAATCCCTTACACAYTGAT

c.1547T > C (p.Ile516Thr)

CCTAACTTTGCTAGTCTAGCA′]

2237
NM_022068.3(PIEZO2):
63895
PIEZO2
[′GTCCATTTGATCATTGTCTCTGGTGRGCGAT

c.8215T > C (p.Ser2739Pro)

ATAGGAATATTAATTTGGCA′]

2238
NM_012079.5(DGAT1):
8694
DGAT1
[′GCACCTCAGGCCCACAGAGGTCCTCRCCGC

c.751 + 2T > C

GGTAGGTCAGATTGTCCGGGT′]

2239
NM_003108.3(SOX11): c.178T >
6664
SOX11
[′GCCGATGAACGCGTTCATGGTATGGYCCAA

C (p.Ser60Pro)

GATCGAACGCAGGAAGATCAT′]

2240
NM_021072.3(HCN1): c.814T > C
348980
HCN1
[′TGATGTATGTATCTAATTAACCTTGRAAGTC

(p.Ser272Pro)

GTAATAAACGCAAGAGACTG′]

2241
NM_001079867.1(PEX2):
5828
PEX2
[′CACCAGTGGCAAAGAATGCGCTCTAYGTGG

c.739T > C (p.Cys247Arg)

AGAGTGGCCCACCATGCCTCA′]

2242
NM_022552.4(DNMT3A):
1788
DNMT3A
[′CTGAATGCCCAAGTCCTTCAGCACCRGGAGC

c.1943T > C (p.Leu648Pro)

CCTGCACCAGCCAGCAGACA′]

2243
NM_022552.4(DNMT3A):
1788
DNMT3A
[′CGCAAAATACTCCTTCAGCGGAGCGRAGAG

c.2705T > C (p.Phe902Ser)

GTGGCGGATGACTGGCACGCT′]

2244
NM_018400.3(SCN3B): c.482T >
55800
SCN3B
[′GAGGAAGACCAGAAGGATGTACATCRTGAT

C (p.Met161Thr)

TTCTGAGACCACAGAGGTGAA′]

2245
NM_000406.2(GNRHR):
2798
GNRHR
[′TTCTCCATGTATGCCCCAGCCTTCAYGATGG

c.392T > C (p.Met131Thr)

TGGTGATCAGCCTGGACCGC′]

2246
NM_001030001.2(RPS29):
6235
RPS29
[′GCAGACGCCTACCTTAATGAAACCGRTATCC

c.149T > C (p.Ile50Thr)

TTCGCGTACTGACGGAAACA′]

2247
NM_177550.4(SLC13A5):
284111
SLC13A5
[′CAGGGTACAGGGCAGCATGATGTACRGCGG

c.1463T > C (p.Leu488Pro)

ATTGAGGCCGATGGAGCGAGA′]

2248
NM_004464.3(FGF5): c.520T > C
2250
FGF5
[′TTTTCAAGAAAATAGCTATAATACCBATGCC

(p.Tyr174His)

TCAGCAATACATAGAACTGA′]

2249
NM_000051.3(ATM):
472
ATM
[′AGAGGACCCTTTTCACTCTTGGAGGYAATAA

c.4776 + 2T > C

AAATTTCATCATCTACTATT′]

2250
NM_002880.3(RAF1): c.1808T >
5894
RAF1
[′GTGTTGGAGCAGCTCAATGGAAGACRGGAT

C (p.Leu603Pro)

CTGAAACAAAGCCCAAGAATG′]

2251
NM_000251.2(MSH2):
4436
MSH2
[′GTCAGAGCCCTTAACCTTTTTCAGGBAAAAA

c.942 + 2T > C

AAAAAAAAAAAAAAAAAAAA′]

2252
NM_001077620.2(PRCD): c.2T >
−1
—
[′GGGAGGGGATGGGGCAGCTGCGCCAYGTGC

C (p.Met1Thr)

ACCACCCTTTTCCTGCTCAGC′]

2253
NM_001142800.1(EYS):
34600
EYS
[′AGCCACAAAGTTTTTATGTGGATCARTATCC

c.9209T > C (p.Ile3070Thr)
7

TCGGAAAGAATTAGACTGTT′]

2254
NM_206933.2(USH2A):
7399
USH2A
[′TCCTAAATTGACAGGTGAAGTATGCYGTCCA

c.9751T > C (p.Cys3251Arg)

GATGAACAGCACAATCGGGT′]

2255
NM_000257.3(MYH7): c.4442T >
−1
—
[′GAGGCTCGCTCCCTCAGCACAGAGCYCTTCA

C (p.Leu1481Pro)

AACTCAAGAACGCCTATGAG′]

2256
NM_000257.3(MYH7): c.4835T >
−1
—
[′GAGACACGCAGCCGCAACGAGGCCCYGAGG

C (p.Leu1612Pro)

GTGAAGAAGAAGATGGAAGGA′]

2257
NM_000257.3(MYH7): c.4937T >
−1
—
[′GAGGCCCAGAAGCAAGTCAAGAGCCYCCAG

C (p.Leu1646Pro)

AGCTTGTTGAAGGTACTCACC′]

2258
NM_001199138.1(NLRC4): c.10
58484
NLRC4
[′AATCTCATGAAGACCCCTCTCTTTGYGGTCA

22T > C (p.Val341Ala)

TCACTTGTGCAATCCAGATG′]

2259
NM_000076.2(CDKNIC):
1028
CDKNIC
[′GCGCAAGAGGCTGCGGTGAGCCAAGYGAGT

c.*5 + 2T > C

ACAGCGCACCTGGGGGGGCGC′]

2260
NM_003159.2(CDKL5): c.659T >
6792
CDKL5
[′CCTGGAGAAAGTGAAATTGACCAACYTTTT

C (p.Leu220Pro)

ACTATTCAGAAGGTGCTAGGA′]

2261
NM_005027.3(PIK3R2):
5296
PIK3R2
[′CTCACCTTCTGCTCCGTTGTGGACCYCATCA

c.1202T > C (p.Leu401Pro)

ATCACTACCGCCACGAGTCT′]

2262
NM_173596.2(SLC39A5):
283375
SLC39A5
[′TTCCTGCTCTTTGTGCTGGAGAACAYGCTGG

c.911T > C (p.Met304Thr)

GGCTTTTGCGGCACCGAGGG′]

2263
NM_153334.6(SCARF2):
91179
SCARF2
[′CCTTGCTGCCTCCAGCCAGCGCAGCRCGTGG

c.190T > C (p.Cys64Arg)

GCACCTGGGAGCTGCGAGCA′]

2264
NM_001288767.1(ARMC5):
79798
ARMC5
[′GGGGCACTTGTGACCGGCCCGGCGCYGTAC

c.1928T > C (p.Leu643Pro)

GGCCTGCTGACCTATGTGACC′]

2265
NM_001288767.1(ARMC5):
79798
ARMC5
[′CGTGAGGCCATCAACCGGGCCCGACYGCGG

c.1379T > C (p.Leu460Pro)

GATGCTGGTGGCTTGGATCTA′]

2266
NC_012920.1: m.9478T > C
4514
MT-CO3
[′ATAATCCTATTTATTACCTCAGAAGYTTTTTT

CTTCGCAGGATTTTTCTGA′]

2267
NC_012920.1: m.11984T > C
4538
MT-ND4
[′ACTAGTCACAGCCCTATACTCCCTCYACATA

TTTACCACAACACAATGGGG′]

2268
NM_014845.5(FIG4): c.50T > C
9896
FIG4
[′ATCAGCTCGGTCCAGAAGCTGGTTCYGTATG

(p.Leul7Pro)

AGACTAGAGCTGTGAGTACC′]

2269
NM_003159.2(CDKL5):
6792
CDKL5
[′TCAAGAAATTCAAGGACAGTGAAGGYAGAT

c.145 + 2T > C

ATATATATATATATATATATA′]

2270
NM_002775.4(HTRA1):
5654
HTRA1
[′CCATCTGATAAGATTAAAAAGTTCCYCACG

c.1091T > C (p.Leu364Pro)

GAGTCCCATGACCGACAGGCC′]

2271
NM_021870.2(FGG): c.1210T > C
2266
FGG
[′ATCTTCATAGTGGTTTTCTTCATGGRATACC

(p.Ser404Pro)

ACCGGGTTTTCCAAGTGGCC′]

2272
NM_017617.3(NOTCH1):
4851
NOTCH1
[′TCGAAGGAGCCCAGCGTGTTGATGCRCTTGC

c.1285T > C (p.Cys429Arg)

CCGCATGCTCGCAGGGGTTG′]

2273
NM_024915.3(GRHL2):
79977
GRHL2
[′GATGATTCAGATTGACACATACAGTYATAA

c.1192T > C (p.Tyr398His)

CAATCGTAGCAATAAACCCAT′]

2274
NM_002049.3(GATA1): c.2T > C
2623
GATA1
[′CGCAGGTTAATCCCCAGAGGCTCCAYGGAG

(p.Met1Thr)

TTCCCTGGCCTGGGGTCCCTG′]

2275
NM_002049.3(GATA1):
2623
GATA1
[′TACTGTGGTGGCTCCGCTCAGCTCAYGAGGG

c.1240T> C (p.Ter414Arg)

CACAGAGCATGGCCTCCAGA′]

2276
NM_005859.4(PURA): c.299T > C
5813
PURA
[′GGCGCGGGCGGCAACAAGAGCCGCCYTACT

(p.Leu100Pro)

CTCTCCATGTCAGTGGCCGTG′]

2277
NM_032374.4(APOPT1):
84334
APOPT1
[′TTCTGGGCAAACCAGAATTTGACTTYTAGTA

c.353T > C (p.Phe118Ser)

AGGTAAGTTTAAGTTTTAGA′]

2278
NM_032551.4(KISS1R): c.937T >
84634
KISS1R
[′TAAGACCTGGGCTCACTGCATGTCCYACAGC

C (p.Tyr313His)

AACTCCGCGCTGAACCCGCT′]

2279
NM_017696.2(MCM9):
254394
MCM9
[′AAAGCTTGATACGATTAGCAGAAGGYCTAT

c.1732 + 2T > C

TTCATTCAGCGAATGATGCTT′]

2280
NM_003159.2(CDKL5): c.602T >
6792
CDKL5
[′GACATGTGGTCGGTGGGCTGTATTCYTGGGG

C (p.Leu201Pro)

AGCTTAGCGATGGACAGCCT′]

2281
NM_005740.2(DNAL4):
10126
DNAL4
[′GAGAAATTCTCCAACAACAACGAGGYATTG

c.153 + 2T > C

CCAGCAGTGCAGGCGGCCCCT′]

2282
NM_201631.3(TGM5): c.763T > C
9333
TGM5
[′TTCAGGATGGCCACGCTGCCCGTCCRCTCCG

(p.Trp255Arg)

CAGGGTTGGCGCCGTCTGTG′]

2283
NM_201631.3(TGM5): c.122T > C
9333
TGM5
[′GCTCCGGTTCCTGAAGTACAGGGTGRGGTTG

(p.Leu41Pro)

AAGGCCTGGCCCCGGCGAAC′]

2284
NM_001287223.1(SCN11A):
11280
SCN11A
[′TACCTTCATTCCTTCAAACTGGGACRGCGCA

c.3473T > C (p.Leu1158Pro)

CGAAGAGGCCTCAGTGCTCG′]

2285
NM_001287223.1(SCN11A):
11280
SCN11A
[′GGGCTCTACTCAGTCTTCTTCTTCAYTGTGG

c.1142T > C (p.Ile381Thr)

TCATTTTCCTGGGCTCCTTC′]

2286
NM_001302946.1(TRNT1):
51095
TRNT1
[′CATGATCCTGAGACTTTGGAAGCAAYTGCA

c.668T > C (p.Ile223Thr)

GAAAATGCAAAAGGCTTGGCT′]

2287
NM_001302946.1(TRNT1):
51095
TRNT1
[′TAATGAATAGGTTTTGATGGCACTTYATTTG

c.497T > C (p.Leu166Ser)

ACTACTTTAATGGTTATGAA′]

2288
NM_018136.4(ASPM):
259266
ASPM
[′ATAGACACCTATGGAAAGATGTGGGYAAGA

c.2419 + 2T > C

AGACTGCAGAAATCTTGACAT′]

2289
NM_022455.4(NSD1): c.5885T >
64324
NSD1
[′TGGGGTCTACGGACAAAAACAGATAYTAAA

C (p.Ile1962Thr)

AAGGTTAGAAAAAGCTAAATT′]

2290
NM_022455.4(NSD1): c.5989T >
64324
NSD1
[′TCAAGAACATGATATCACTAATTTCYATATG

C (p.Tyr1997His)

CTCACCCTAGACAAAGTAAG′]

2291
NM_133433.3(NIPBL):
25836
NIPBL
[′AAAAAATATGCTGGATTCATTCATGYATGTA

c.7062 + 2T > C

TTTTAACATTTTATAACCTA′]

2292
NM_000525.3(KCNJ11):
3767
KCNJ11
[′GGAGGACGGACGTTACTCTGTGGACYACTC

c.988T > C (p.Tyr330His)

CAAGTTTGGCAACACCGTCAA′]

2293
NM_004004.5(GJB2): c.107T > C
2706
GJB2
[′CTCTTCATTTTTCGCATTATGATCCYCGTTGT

(p.Leu36Pro)

GGCTGCAAAGGAGGTGTGG′]

2294
NM_130838.1(UBE3A):
7337
UBE3A
[′CTTTAATGTGCTTTTACTTCCGGAAYACTCA

c.2485T > C (p.Tyr829His)

AGCAAAGAAAAACTTAAAGA′]

2295
NM_005682.6(ADGRG1):
9289
ADGRG1
[′GCCATCTTCCTGCACTTCTCCCTGCYCACCT

c.1460T > C (p.Leu487Pro)

GCCTTTCCTGGATGGGCCTC′]

2296
NM_000430.3(PAFAH1B1):
5048
PAFAH1B1
[′CCGAGAGCATGAGCATGTGGTAGAAYGCAT

c.841T > C (p.Cys281Arg)

TTCCTGGGCTCCAGAAAGCTC′]

2297
NM_001005360.2(DNM2):
1785
DNM2
[′GTGGACAGCTGGAAGGCCTCGTTCCYCCGA

c.1862T > C (p.Leu621Pro)

GCTGGCGTCTACCCCGAGAAG′]

2298
NM_178151.2(DCX): c.683T > C
1641
DCX
[′CTGGAGACCGGGGTTGTCAAAAAACYCTAC

(p.Leu228Pro)

ACTCTGGATGGAAAACAGGTA′]

2299
NM_178151.2(DCX): c.641T > C
1641
DCX
[′TCTTTTGAGCAAGTCCTCACTGATAYCACAG

(p.Ile214Thr)

AAGCCATCAAACTGGAGACC′]

2300
NM_178151.2(DCX): c.412T > C
1641
DCX
[′AGACAACTTCTTTAAAAAGGTGGAGYACAC

(p.Tyr138His)

CAAGAATGTCAATCCCAACTG′]

2301
NM_178151.2(DCX): c.272T > C
1641
DCX
[′TTGCTGGCTGACCTGACGCGATCTCYGTCTG

(p.Leu91Pro)

ACAACATCAACCTGCCTCAG′]

2302
NM_178151.2(DCX): c.128T > C
1641
DCX
[′TGTAGCTTCTACCGAACCAGAACCTYGCAG

(p.Leu43Ser)

GCACTGAGTAATGAGAAGAAA′]

2303
NM_178151.2(DCX): c.2T > C
1641
DCX
[′AGGTCTCTGAGGTTCCACCAAAATAYGGAA

(p.Met1Thr)

CTTGATTTTGGACACTTTGAC′]

2304
NM_000252.2(MTM1): c.260T >
4534
MTM1
[′TCTTCTCTAATACTTGATGTTCCTCYGGGTGT

C (p.Leu87Pro)

GATCTCGAGAATTGAAAAA′]

2305
NM_000252.2(MTM1): c.683T >
4534
MTM1
[′AACTTTCTGACTTAACCATAGGTGCYGTCAT

C (p.Leu228Pro)

GGATTCATCCAGAAAATAAG′]

2306
NM_000252.2(MTM1): c.958T >
4534
MTM1
[′TCATAATATTCATGTTATGCGGGAAYCTTTA

C (p.Ser320Pro)

AAAAAAGTGAAGGACATTGT′]

2307
NM_000252.2(MTM1):
4534
MTM1
[′TGTGTGTGGCAAATGTCAAAACAGGYAAGG

c.1353 + 2T > C

AATATGAGGGATGAAAATACA′]

2308
NM_000252.2(MTM1): c.1367T >
4534
MTM1
[′GTTTTTGTTTAGTTCCCTACAGCTTYTGAATT

C (p.Phe456Ser)

CAATGAACAATTTTTGATT′]

2309
NM_000252.2(MTM1): c.1433T >
4534
MTM1
[′CTGTATAGTTGCCGATTTGGTACTTYCTTATT

C (p.Phe478Ser)

CAACTGTGAATCTGCTCGA′]

2310
NM_000252.2(MTM1): c.1495T >
4534
MTM1
[′GGTTACAGAAAGGACTGTTTCTTTAYGGTCA

C (p.Trp499Arg)

CTGATAAACAGTAATAAAGA′]

2311
NM_006579.2(EBP): c.310T > C
10682
EBP
[′TCTCTTCTTTTCTTCAGGGAAAGAGYATGCC

(p.Tyr104His)

AAGGGAGACAGCCGATACAT′]

2312
NM_152296.4(ATP1A3):
478
ATP1A3
[′GAGCCTGCCTGTGCCACAGGCCGCCYGATCT

c.2270T > C (p.Leu757Pro)

TCGACAACCTAAAGAAGTCC′]

2313
NM_152296.4(ATP1A3):
478
ATP1A3
[′GTGGCCCTGTCTCACATCGCTGGGCYCTGCA

c.1250T > C (p.Leu417Pro)

ATCGCGCTGTCTTCAAGGGT′]

2314
NM_152296.4(ATP1A3):
478
ATP1A3
[′GAACCGCATGACAGTCGCCCACATGYGGTT

c.1144T > C (p.Trp382Arg)

TGACAACCAGATCCACGAGGC′]

2315
NM_152296.4(ATP1A3):
478
ATP1A3
[′ATCTGCTCAGATAAGACAGGGACCCYCACT

c.1112T > C (p.Leu371Pro)

CAGAACCGCATGACAGTCGCC′]

2316
NM_004963.3(GUCY2C):
−1
—
[′CTTTCTGTCCTTCATTTCAGGTCCCYGTGCTG

c.2782T > C (p.Cys928Arg)

CTGGAGTTGTGGGAATCAA′]

2317
NM_000109.3(DMD): c.1700T >
1756
DMD
[′GTTCACTGCATCTTCTTTTTCTGAARGCCATG

C (p.Leu567Pro)

CACTAAAAAGGCACTGCAA′]

2318
NM_001543.4(NDST1):
3340
NDST1
[′CAGCAACTACCCCAGCTCTGAGACCYTTGA

c.1918T > C (p.Phe640Leu)

GGAGATCCAGTTTTTTAATGG′]

2319
NM_001999.3(FBN2): c.3740T >
2201
FBN2
[′GGTGTCACAGCCTCCGTTCATTATCRTACAT

C (p.Met1247Thr)

TCATCAATATCTGTGAAAAC′]

2320
NM_005154.4(USP8): c.2152T >
9101
USP8
[′ACCTTCCAAACTGAAGCGCTCCTACYCCTCC

C (p.Ser718Pro)

CCAGATATAACCCAGGCTAT′]

2321
NM_000734.3(CD247): c.2T > C
919
CD247
[′CCTCTTTCTGAGGGAAAGGACAAGAYGAAG

(p.Met1Thr)

TGGAAGGCGCTTTTCACCGCG′]

2322
NM_000663.4(ABAT): c.1433T >
18
ABAT
[′AAATCCATTCGTTTCCGTCCCACGCYGGTCT

C (p.Leu478Pro)

TCAGGGATCACCACGCTCAC′]

2323
NM_005211.3(CSF1R): c.2717T >
1436
CSF1R
[′ACCCACAGACCCACCTTCCAGCAGAYCTGCT

C (p.Ile906Thr)

CCTTCCTTCAGGAGCAGGCC′]

2324
NM_005211.3(CSF1R): c.2566T >
1436
CSFIR
[′CTTGGCCTTTGCAGGGCTGAATCCCYACCCT

C (p.Tyr856His)

GGCATCCTGGTGAACAGCAA′]

2325
NM_005211.3(CSF1R): c.2480T >
1436
CSF1R
[′GTGAAGTGGATGGCCCCAGAGAGCAYCTTT

C (p.Ile827Thr)

GACTGTGTCTACACGGTTCAG′]

2326
NM_005211.3(CSF1R): c.2450T >
1436
CSF1R
[′TGGGGACTGTCATCCCAGGCCCGCCYGCCTG

C (p.Leu817Pro)

TGAAGTGGATGGCCCCAGAG′]

2327
NM_005211.3(CSF1R): c.1957T >
1436
CSF1R
[′GAACATCGTCAACCTTCTGGGAGCCYGTACC

C (p.Cys653Arg)

CATGGAGGTAAGGGCCTTGG′]

2328
NM_005211.3(CSF1R): c.1745T >
1436
CSF1R
[′AAGTGGGAGTTCCCCCGGAACAACCYGCAG

C (p.Leu582Pro)

TTTGGTGAGATGGCAGCTCAT′]

2329
NM_001563.3(IMPG1): c.461T >
3617
IMPG1
[′AATTCCCAGGAGCACCTGGATCTTCYCCAGC

C (p.Leu154Pro)

AGGTGAGCCTAAACACCACA′]

NM_001130823.1(DNMT1):
1786
DNMT1
[]

c.1531T > C (p.Tyr511His)

2330
NM_152515.4(CKAP2L): c.2T > C
150468
CKAP2L
[′AGCAGCGGTAGGCCCGGGCCCCACCRTGAC

(p.Met1Thr)

TCTTCAGTGACAGTTTTTCTT′]

2331
NM_170707.3(LMNA):
4000
LMNA
[′GGCAACTCCAGCCCCCGAACCCAGGNGAGT

c.1968 + 2T > C

TGTCTCTGCTTTGTCTCCAAA′]

2332
NM_153818.1(PEX10): c.890T >
5192
PEX10
[′AGAAACCCCCTGTGCACCCTGTGCCYGGAG

C (p.Leu297Pro)

GAGCGCAGGCACCCAACAGCC′]

2333
NM_153818.1(PEX10): c.2T > C
5192
PEX10
[′TCGGGACCACCCGAACCCGCGGCCAYGGCC

(p.Met1Thr)

CCGGCCGCCGCCAGCCCCCCG′]

2334
NM_014305.3(TGDS): c.700T > C
23483
TGDS
[′AATGCTTCTACAACATCAGTAGCATRAAGG

(p.Tyr234His)

AAGTTTCTTGTTTGAAGCCCT′]

2335
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GTGAACCTTCTCATCCCTTTCCAGGYGGGAC

c.2994 + 2T > C

TGGCCCCCTTCCCTGTCCCC′]

2336
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CTCATGTGCCCCCCCAGCCAGGCTCDCCCTG

c.1624 + 2T > C

CACAATGAGCTCAGCCAGCG′]

2337
NM_000257.3(MYH7): c.2207T >
4625
MYH7
[′GCGGCCATCCCTGAGGGACAGTTCAHTGAT

C (p.Ile736Thr)

AGCAGGAAGGGGGCAGAGAAG′]

2338
NM_000138.4(FBN1): c.7754T >
2200
FBN1
[′TGCCAGCATGGCTGCCAGAACATCAYTGGG

C (p.Ile2585Thr)

GGCTACAGGTGCAGCTGCCCC′]

2339
NM_000371.3(TTR): c.190T > C
7276
TTR
[′GGCTGCTGATGACACCTGGGAGCCAYTTGC

(p.Phe64Leu)

CTCTGGGTAAGTTGCCAAAGA′]

2340
NM_000126.3(ETFA): c.2T > C
2108
ETFA
[′GAGGTTGCGGCGGAAGCGGAGACCAYGTTC

(p.Met1Thr)

CGAGCGGCGGCTCCGGGGCAG′]

2341
NM_006493.2(CLN5): c.2T > C
1203
CLN5
[′GCGGGCCGGGCGCGGGGAGGTGTCAYGCGC

(p.Met1Thr)

CGGAACCTGCGCTTGGGGCCA′]

2342
NM_000543.4(SMPD1): c.475T >
6609
SMPD1
[′CTCAGTGCTGAGCCCATCTGAGGCCYGTGGC

C (p.Cys159Arg)

CTGCTCCTGGGCTCCACCTG′]

2343
NM_000501.3(ELN):
2006
ELN
[′TTCCTGGAATTGGAGGCATCGCAGGYAACA

c.889 + 2T > C

TCTGTCCCAGCAGGGGGCGGG′]

2344
NM_000169.2(GLA): c.758T > C
−1
—
[′TGGACATCTTTTAACCAGGAGAGAAYTGTTG

(p.Ile253Thr)

ATGTTGCTGGACCAGGGGGT′]

2345
NM_152743.3(BRAT1): c.176T >
221927
BRAT1
[′GAGCACCCCTGCCTGGTGGAGCTGCYGTCCC

C (p.Leu59Pro)

ATGTGCTGAAAGTCCAGGAC′]

2346
NM_000152.3(GAA): c.896T > C
2548
GAA
[′CTCTACGGGTCTCACCCTTTCTACCBGGCGC

(p.Leu299Pro)

TGGAGGACGGCGGGTCGGCA′]

2347
NM_015384.4(NIPBL): c.7637T >
25836
NIPBL
[′AATGTGTCCCAGGGTATTTTATTACYTCTCA

C (p.Leu2546Pro)

TGTTAAAACAACATTTGAAG′]

2348
NM_005641.3(TAF6): c.212T > C
6878
TAF6
[′ATTCTTTAGCTTCAAGGCGTAGTCADTGTCA

(p.Ile71Thr)

CTGGTGGTGAGCTTCTGCCG′]

2349
NM_170707.3(LMNA): c.710T >
4000
LMNA
[′ATTGACAATGGGAAGCAGCGTGAGTYTGAG

C (p.Phe237Ser)

AGCCGGCTGGCGGATGCGCTG′]

2350
NM_000527.4(LDLR): c.1468T >
3949
LDLR
[′GGACTGGATCCACAGCAACATCTACYGGAC

C (p.Trp490Arg)

CGACTCTGTCCTGGGCACTGT′]

2351
NM_000081.3(LYST): c.772T > C
1130
LYST
[′CATGAACAATTCTCCATTTGACTTAYGTCAT

(p.Cys258Arg)

GTTTTGTTATCTTTATTAGA′]

2352
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CTTACAGGGCGAGGCACGGTGTGAGYGCCG

c.3796T > C (p.Cys1266Arg)

CCTGGAGGTGCGAGGTGAGGA′]

2353
NM_000256.3(MYBPC3):
4607
MYBPC3
[′TTCAGCAAGCAGGGAGTGTTGACTCYGGAG

c.3713T > C (p.Leu1238Pro)

ATTAGAAAGCCCTGCCCCTTT′]

2354
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CAGAAAGCCGACAAGAAGACCATGGBGAGC

c.3330 + 2T > C

CCAGGGTCTGGGGTCCCCACG′]

2355
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CGCAAAGGACCAGGCGGTGTTCAAAYGTGA

c.1696T > C (p.Cys566Arg)

GGTCTCAGATGAGAATGTTCG′]

2356
NM_000256.3(MYBPC3):
4607
MYBPC3
[′ATCGGAGGAGGGGGCGCAAGTCAAABGGTG

c.1456T > C (p.Trp486Arg)

AGTTCCAGAAGCACGGGGCAT′]

2357
NM_000256.3(MYBPC3):
4607
MYBPC3
[′TGCCCAGCCTGCCTTCACTGGCAGCYACCGC

c.709T > C (p.Tyr237His)

TGTGAGGTGTCCACCAAGGA′]

2358
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GGAGCCCCCGATGACCCCATTGGCCYCTTCG

c.467T > C (p.Leu156Pro)

TGATGCGGCCACAGGATGGC′]

2359
NM_000257.3(MYH7): c.2723T >
4625
MYH7
[′GATGCTGAGGAGCGCTGTGATCAGCYGATC

C (p.Leu908Pro)

AAAAACAAGATTCAGCTGGAG′]

2360
NM_000257.3(MYH7): c.2479T >
4625
MYH7
[′TCGGGCCTTCATGGGGGTCAAGAATYGGCC

C (p.Trp827Arg)

CTGGATGAAGCTCTACTTCAA′]

2361
NM_000257.3(MYH7): c.1400T >
4625
MYH7
[′GTCCTGGACATCGCTGGCTTCGAGAYCTTCG

C (p.Ile467Thr)

ATGTGAGTTGGGACCCCTGG′]

2362
NM_000257.3(MYH7): c.1048T >
4625
MYH7
[′CACTTCAGAGGAGAAAAACTCCATGYATAA

C (p.Tyr350His)

GCTGACAGGCGCCATCATGCA′]

2363
NM_000257.3(MYH7): c.730T >
4625
MYH7
[′CGTCCGGAACGACAACTCCTCCCGCYTCGTG

C (p.Phe244Leu)

AGTGGTCCCTGACCTTGGCC′]

2364
NM_005159.4(ACTC1): c.755T >
−1
—
[′CTGCCTGATGGCCAAGTCATCACTAYTGGCA

C (p.Ile252Thr)

ATGAGCGCTTCCGCTGTCCT′]

2365
NM_030662.3(MAP2K2):
5605
MAP2K2
[′GCAGCAGAAGAAGCGGCTGGAAGCCNTTCT

c.169T> C (p.Phe57Leu)

CACCCAGAAAGCCAAGGTCGG′]

2366
NM_000169.2(GLA): c.41T > C
−1
—
[′CCAGAACTACATCTGGGCTGCGCGCYTGCG

(p.Leu14Pro)

CTTCGCTTCCTGGCCCTCGTT′]

2367
NM_002294.2(LAMP2):
3920
LAMP2
[′TATCTAGACTTTGTCTTTGCTGTGGYGAGTA

c.864 + 2T > C

ACAGATTTTTTAAAGTTAGG′]

2368
NM_000551.3(VHL): c.227T > C
7428
VHL
[′TCGCGCGAGCCCTCCCAGGTCATCTYCTGCA

(p.Phe76Ser)

ATCGCAGTCCGCGCGTCGTG′]

2369
NM_000551.3(VHL): c.266T > C
7428
VHL
[′CCGCGCGTCGTGCTGCCCGTATGGCHCAACT

(p.Leu89Pro)

TCGACGGCGAGCCGCAGCCC′]

2370
NM_000551.3(VHL): c.473T > C
7428
VHL
[′GTTTTTGCCCTTCCAGTGTATACTCHGAAAG

(p.Leu158Pro)

AGCGATGCCTCCAGGTTGTC′]

2371
NM_000051.3(ATM):
−1
—
[′GCAGTGTAGCTACTTCTTCTATTGGYAATCT

c.8584 + 2T > C

TCTTGTACATATAGTAGATT′]

2372
NM_058216.2(RAD51C):
5889
RAD51C
[′AGGTGTTGGAAAAACACAATTATGGYAAAA

c.404 + 2T > C

TAAAGTGTTCTCCTTTTAAGG′]

2373
NM_000455.4(STK11): c.545T >
6794
STK11
[′CACAAGGACATCAAGCCGGGGAACCYGCTG

C (p.Leu182Pro)

CTCACCACCGGTGGCACCCTC′]

2374
NM_001199107.1(TBC1D24):
57465
TBC1D24
[′GGACAACACGCAGGTGCCCAGCTACYGCCT

c.313T > C (p.Cys105Arg)

GAATGCACGCGGCGAGGGGGC′]

2375
NM_000899.4(KITLG): c.98T > C
4254
KITLG
[′ACTGAAGGGATCTGCAGGAATCGTGYGACT

(p.Val33Ala)

AATAATGTAAAAGACGTCACT′]

2376
NM_001195129.1(PRSS56):
646960
PRSS56
[′GCAGTGCCTGCAGCGCCGGCGGCGAYGCGG

c.1183T > C (p.Cys395Arg)

TCAGTTCTGTTCACCCGGACC′]

2377
NM_006888.4(CALM1): c.268T >
801
CALM1
[′TAGTGAAGAAGAAATCCGTGAGGCAYTCCG

C (p.Phe90Leu)

AGTCTTTGACAAGGTAATCCA′]

2378
NM_017534.5(MYH2): c.5609T >
−1
—
[′GAAGATAGAAAGAATATTCTCAGGCYTCAA

C (p.Leu1870Pro)

GATTTGGTAGATAAACTTCAG′]

2379
NM_003000.2(SDHB): c.574T > C
6390
SDHB
[′CTACGAGTGCATTCTCTGTGCCTGCYGTAGC

(p.Cys192Arg)

ACCAGCTGCCCCAGCTACTG′]

2380
NM_000314.6(PTEN): c.406T > C
5728
PTEN
[′AAAGGGACGAACTGGTGTAATGATAYGTGC

(p.Cys136Arg)

ATATTTATTACATCGGGGCAA′]

2381
NM_000051.3(ATM): c.2T > C
472
ATM
[′ATGTGTGTTCTGAAATTGTGAACCAYGAGTC

(p.Met1Thr)

TAGTACTTAATGATCTGCTT′]

2382
NM_052867.2(NALCN):
259232
NALCN
[′GGTCCTGGAAAAAAGCTTGGGAGTTYGGTT

c.1526T > C (p.Leu509Ser)

GTATTTACTGCCAGCCTCTTG′]

2383
NM_000314.6(PTEN): c.545T > C
5728
PTEN
[′TATGTGTATTATTATAGCTACCTGTYAAAGA

(p.Leu182Ser)

ATCATCTGGATTATAGACCA′]

2384
NM_005957.4(MTHFR):
4524
MTHFR
[′ACGCAGGGCGTCAGGACGCAGGGTCRTGGA

c.1969T > C (p.Ter657Arg)

GCCTCCGTTTCTCTCGCATTC′]

2385
NM_005957.4(MTHFR):
4524
MTHFR
[′AACCTGGTGGACAATGACTTCCCACYGGAC

c.1883T > C (p.Leu628Pro)

AACTGCCTCTGGCAGGTGGTG′]

2386
NM_005957.4(MTHFR):
4524
MTHFR
[′CTGTGGATTGAGCGGTGGGGAAAGCYGTAT

c.1793T > C (p.Leu598Pro)

GAGGAGGAGTCCCCGTCCCGC′]

2387
NM_005957.4(MTHFR):
4524
MTHFR
[′AGCGGGGGCTATGTCTTCCAGAAGGYGTGG

c.1530 + 2T > C

TAGGGAGGCACGGGGTGCCCC′]

2388
NM_005957.4(MTHFR): c.388T >
4524
MTHFR
[′CCTGGAGACCATCCTGCACATGACCYGCTGC

C (p.Cys130Arg)

CGTCAGCGCCTGGAGGAGAT′]

2389
NM_000264.3(PTCH1):
5727
PTCH1
[′AACCCCTGGACGGCCGGGATCATTGYGAGT

c.3168 + 2T > C

GTATTATAAGGGGCTTTGTGG′]

2390
NM_000030.2(AGXT): c.302T > C
189
AGXT
[′GTGCTGGAGCCTGGGGACTCCTTCCYGGTTG

(p.Leu101Pro)

GGGCCAATGGCATTTGGGGG′]

2391
NM_000030.2(AGXT): c.322T > C
189
AGXT
[′CTTCCTGGTTGGGGCCAATGGCATTYGGGGG

(p.Trp108Arg)

CAGCGAGCCGTGGACATCGG′]

2392
NM_000023.2(SGCA): c.371T > C
6442
SGCA
[′ACTCGGCAGAGGCTGGTGCTGGAGAYTGGG

(p.Ile124Thr)

GACCCAGAAGGTACCTCTAGC′]

2393
NM_016035.4(COQ4): c.155T > C
51117
COQ4
[′CGCCATCGCCGCGGAGCCGGCGGCCRACAG

(p.Leu52Ser)

CCCTTTCTGCAGCGGGGAGGT′]

2394
NM_000510.2(FSHB): c.298T > C
2488
FSHB
[′GTATACATACCCAGTGGCCACCCAGYGTCA

(p.Cys100Arg)

CTGTGGCAAGTGTGACAGCGA′]

2395
NM_007374.2(SIX6): c.110T > C
4990
SIX6
[′CGCCTGGGTCGCTTCCTCTGGTCGCYGCCCG

(p.Leu37Pro)

TGGCCCCTGCGGCCTGCGAG′]

2396
NM_000314.6(PTEN): c.202T > C
5728
PTEN
[′AAAGCATAAAAACCATTACAAGATAHACAA

(p.Tyr68His)

TCTGTAAGTATGTTTTCTTAT′]

2397
NM_001103.3(ACTN2): c.683T >
88
ACTN2
[′GAGAAGCACCTGGATATTCCTAAAAYGTTG

C (p.Met228Thr)

GATGCTGAAGGTGAGATGAAA′]

2398
NM_005249.4(FOXG1): c.700T >
2290
FOXG1
[′GCAGAACTCCATCCGCCACAATCTGYCCCTC

C (p.Ser234Pro)

AACAAGTGCTTCGTGAAGGT′]

2399
NM_001165963.1(SCN1A):
−1
—
[′ATTCCATCCATCATGAATGTGCTTCYGGTTT

c.4055T > C (p.Leul352Pro)

GTCTTATATTCTGGCTAATT′]

2400
NM_001165963.1(SCN1A):
6323
SCN1A
[′GCTCTGGGAAATTTAACCCTCGTCTYGGCCA

c.2690T > C (p.Leu897Ser)

TCATCGTCTTCATTTTTGCC′]

2401
NM_001165963.1(SCN1A):
6323
SCN1A
[′CTAATAAATTTGATCCTGGCTGTGGHGGCCA

c.1265T > C (p.Val422Ala)

TGGCCTACGAGGAACAGAAT′]

2402
NM_001165963.1(SCN1A):
6323
SCN1A
[′TTTCTTTTACCCCACTTGCAGCCAAYGTCCA

c.1033T > C (p.Cys345Arg)

GAGGGATATATGTGTGTGAA′]

2403
NM_001165963.1(SCN1A):
6323
SCN1A
[′AGATGTAATGATCCTGACTGTGTTCYGTCTG

c.769T > C (p.Cys257Arg)

AGCGTATTTGCTCTAATTGG′]

2404
NM_001165963.1(SCN1A):
6323
SCN1A
[′TTCCGGTTCAGTGCCACCTCTGCCCYGTACA

c.323T > C (p.Leu108Pro)

TTTTAACTCCCTTCAATCCT′]

2405
NM_000426.3(LAMA2):
3908
LAMA2
[′GCAGAATCAGAACCAGCTCTTTTGAYAGGG

c.8282T > C (p.Ile2761Thr)

AGCAAGCAGTTCGGGCTTTCA′]

2406
NM_001199.3(BMP1):
649
BMP1
[′GTCTGTGACATTTCCTGTTGTGAAGYAAAAG

c.*241T > C

AGGGACCCCTGCGTCCTGCT′]

2407
NM_001987.4(ETV6): c.1046T >
2120
ETV6
[′CTTTGGGATTACGTCTATCAGTTGCYTTCTG

C (p.Leu349Pro)

ACAGCCGGTACGAAAACTTC′]

2408
NM_004974.3(KCNA2): c.788T >
3737
KCNA2
[′ATGAACATCATTGACATTGTGGCCAYCATCC

C (p.Ile263Thr)

CCTACTTCATCACCCTGGGG′]

2409
NM_002055.4(GFAP): c.791T > C
2670
GFAP
[′GTGTCCCCCACCTAGTTTGCAGACCYGACAG

(p.Leu264Pro)

ACGCTGCTGCCCGCAACGCG′]

2410
NM_002055.4(GFAP): c.239T > C
2670
GFAP
[′GAGATGATGGAGCTCAATGACCGCTYTGCC

(p.Phe80Ser)

AGCTACATCGAGAAGGTTCGC′]

2411
NM_002055.4(GFAP): c.218T > C
2670
GFAP
[′ACCCGGGCCAGTGAGCGGGCAGAGADGATG

(p.Met73Thr)

GAGCTCAATGACCGCTTTGCC′]

2412
NM_001288953.1(TTC7A): c.191
57217
TTC7A
[′TTTGCCTGATGCCCATGATGCAGACYCTGGT

2T > C (p.Ser638Pro)

AAGAACGAGCTCCTTGGGCC′]

2413
NM_000257.3(MYH7): c.5117T >
−1
—
[′TCCCGGAAGCTGGCGGAGCAGGAGCYGATT

C (p.Leu1706Pro)

GAGACTAGTGAGCGGGTGCAG′]

2414
NM_000257.3(MYH7): c.4772T >
−1
—
[′ATGGAACAGGCCAAGCGCAACCACCWGCG

C (p.Leu1591Pro)

GGTGGTGGACTCGCTGCAGACC′]

2415
NM_016218.2(POLK): c.609T > C
51426
POLK
[′TGAGTCTTGATGAAGCCTACTTGAAYATAAC

(p.Asn203=)

AAAGCACTTAGAAGAAAGAC′]

2416
NM_016218.2(POLK): c.*66T > C
51426
POLK
[′TATTTTATAATCAATGAATTTGTTCYTTCTGA

TTTTAAGTTTGCAGATTTA′]

2417
NM_015662.2(IFT172): c.770T >
26160
IFT172
[′AGTCCTGGGGGCCAGTCTGTTGTGCYAGGA

C (p.Leu257Pro)

AGTTATGACAGGTAAGTCCCC′]

2418
NM_178454.4(DRAM2): c.79T >
128338
DRAM2
[′GACATCTGCTGCTTTCATATTTTCAYACATT

C (p.Tyr27His)

ACTGCAGTAACACTCCACCA′]

2419
NM_032790.3(ORAI1): c.581T >
84876
ORAI1
[′CTCTTCCTAGCTGAGGTGGTGCTGCYCTGCT

C (p.Leu194Pro)

GGGTCAAGTTCTTGCCCCTC′]

2420
NM_001135669.1(XPR1):
9213
XPR1
[′GAGTTCTACCTCAGTCTAATCCTGCYGCAGA

c.434T > C (p.Leu145Pro)

ACTATCAGGTACTTAGATTC′]

2421
NM_001135669.1(XPR1):
9213
XPR1
[′AAACTGGCCTTCAGTGAGTTCTACCYCAGTC

c.419T > C (p.Leu140Pro)

TAATCCTGCTGCAGAACTAT′]

2422
NM_001135669.1(XPR1):
9213
XPR1
[′GACAGACAAAAGGCTATGAAGCGTTYACGT

c.653T > C (p.Leu218Ser)

GTCCCCCCTTTGGGAGCTGCT′]

2423
NM_005859.4(PURA): c.218T > C
5813
PURA
[′CGGGTGGACATCCAGAACAAGCGCTYCTAC

(p.Phe73Ser)

CTGGACGTGAAGCAGAACGCC′]

2424
NM_005859.4(PURA): c.563T > C
5813
PURA
[′CTGGGCTCCACGCAGGGCCAGACCAYTGCG

(p.Ile188Thr)

CTGCCCGCGCAGGGGCTCATC′]

2425
NM_001399.4(EDA):
1896
EDA
[′TCTGACTCCCAGGACGGGCACCAGGKGAGT

c.396 + 2T > C

CACCTAGTAGGGGCGGCGGCG′]

2426
NM_001848.2(COL6A1):
1291
COL6A1
[′TCCAGGGGACCCAAGGGCTACAAGGYGAGC

c.957 + 2T > C

GTGGGCTGCTGGGAGGGGGGA′]

2427
NM_000454.4(SOD1): c.341T > C
6647
SOD1
[′TCACTCTCAGGAGACCATTGCATCAYTGGCC

(p.Ile114Thr)

GCACACTGGTGGTAAGTTTT′]

2428
NM_020451.2(SEPN1):
57190
SEPN1
[′CTTCTACTACACTGTGATGTTCCGGYGAGTG

c.872 + 2T > C

GGCCACACTGGCTGGCCTGG′]

2429
NM_004453.3(ETFDH):
2110
ETFDH
[′GGTCTAGACTATCAGAATCCATACCYGAGTC

c.1001T > C (p.Leu334Pro)

CATTTAGAGAGTTCCAAAGG′]

2430
NM_198056.2(SCN5A):
6331
SCN5A
[′CAGCTGTGGACTCCAGGGGGGTAGGYTGCC

c.4299 + 6T > C

ACAGTGGCTTCTTCCACCAAG′]

2431
NM_198056.2(SCN5A):
6331
SCN5A
[′TTCACAGGGATTTTCACAGCAGAGABGACCT

c.2291T > C (p.Met764Thr)

TCAAGATCATTGCCCTCGAC′]

2432
NM_198056.2(SCN5A):
6331
SCN5A
[′AGAGTTAGAGGAGTCTCGCCACAAGBGTCC

c.2047T > C (p.Cys683Arg)

ACCATGCTGGAACCGTCTCGC′]

2433
NM_004415.2(DSP): c.4961T > C
1832
DSP
[′GAAAAGCAGAGGACCCAGGAAGAGCYGAG

(p.Leu1654Pro)

GAGGCTCTCTTCTGAGGTCGAG′]

2434
NM_000238.3(KCNH2):
3757
KCNH2
[′CGGGGCGACGTCGTCGTGGCCATCCYGGGT

c.2396T > C (p.Leu799Pro)

ATGGGGTGGGGGGCGGGCACT′]

2435
NM_000238.3(KCNH2):
3757
KCNH2
[′TTCATCTCCCGGGGCTCCATCGAGAYCCTGC

c.2366T > C (p.Ile789Thr)

GGGGCGACGTCGTCGTGGCC′]

2436
NM_000238.3(KCNH2):
3757
KCNH2
[′CTGCGTCATGCTCATTGGCTGTGAGYGTGCC

c.1945 + 6T > C

CAGGGGCGGGCGGCGGGGAG′]

2437
NM_000238.3(KCNH2):
3757
KCNH2
[′TCCCAACACCAACTCAGAGAAGATCBTCTCC

c.1918T > C (p.Phe640Leu)

ATCTGCGTCATGCTCATTGG′]

2438
NM_000238.3(KCNH2):
3757
KCNH2
[′CTACACGGCTGTCTTCACACCCTACYCGGCT

c.1282T > C (p.Ser428Pro)

GCCTTCCTGCTGAAGGAGAC′]

2439
NM_000238.3(KCNH2): c.125T >
3757
KCNH2
[′GCTCGGGTGGAGAACTGCGCCGTCAHCTAC

C (p.Ile42Thr)

TGCAACGACGGCTTCTGCGAG′]

2440
NM_000218.2(KCNQ1):
3784
KCNQ1
[′GTCTTTGCCATCTCCTTCTTTGCGCYCCCAGC

c.1025T > C (p.Leu342Pro)

GGTAGGTGCCCCGTGGGTG′]

2441
NM_000218.2(KCNQ1):
3784
KCNQ1
[′CCCAAACCCAAGAAGTCTGTGGTGGYGAGT

c.1251 + 2T > C

AGCCCACCTGCCACCAGGGCA′]

2442
NM_130799.2(MEN1): c.547T > C
4221
MEN1
[′CCTCGCCCTGTCTGAGGATCATGCCYGGGTA

(p.Trp183Arg)

GTGTTTGGGCCCAATGGGGA′]

2443
NM_000138.4(FBN1): c.7531T >
2200
FBN1
[′CACCATTGGCGGCTTCACATGCAAAYGTCCT

C (p.Cys2511Arg)

CCCGGATTTACCCAACACCA′]

2444
NM_000138.4(FBN1): c.7111T >
2200
FBN1
[′ATGCTGCTGTGACGGAGGGAGAGGCYGGGG

C (p.Trp2371Arg)

TCCCCACTGTGAGATCTGCCC′]

2445
NM_000138.4(FBN1): c.6274T >
2200
FBN1
[′CTGCTGTGCCTTGAAGGGAGAAGGCYGGGG

C (p.Trp2092Arg)

AGACCCCTGCGAGCTCTGCCC′]

2446
NM_000138.4(FBN1): c.5746T >
2200
FBN1
[′CACAATTGGTTCCTTCAACTGCCGCYGCAAT

C (p.Cys1916Arg)

CATGGTTTCATCCTTTCTCA′]

2447
NM_000138.4(FBN1): c.5726T >
2200
FBN1
[′GGGAATGGAACTTGCCGGAACACAAYTGGT

C (p.Ile1909Thr)

TCCTTCAACTGCCGCTGCAAT′]

2448
NM_000138.4(FBN1): c.1468 + 2T
2200
FBN1
[′TGGACCTCCGTGGGGAGTGTATTGGYACGT

> C

GATCCATCCTAGGTTGGCACC′]

2449
NM_004572.3(PKP2): c.2386T >
5318
PKP2
[′TCTCATTGAAACTACAGCCTCTGCCYGTTAC

C (p.Cys796Arg)

ACATTGAACAACATAATCCA′]

2450
NM_004333.4(BRAF): c.1783T >
673
BRAF
[′AGACCTCACAGTAAAAATAGGTGATYTTGG

C (p.Phe595Leu)

TCTAGCTACAGTGAAATCTCG′]

2451
NM_000543.4(SMPD1): c.416T >
6609
SMPD1
[′GCCGTGTGCCAATCCATTGTCCACCYCTTTG

C (p.Leu139Pro)

AGGATGACATGGTGGAGGTG′]

2452
NM_000016.5(ACADM):
34
ACADM
[′GAAGCAGATACCCCAGGAATTCAGAHTGGG

c.698T > C (p.Ile233Thr)

AGAAAGGTAAAGTATTTATTA′]

2453
NM_004453.3(ETFDH):
2110
ETFDH
[′AGGAGGACCTGCTTACAATGGAATGYAAAC

c.1852T > C (p.Ter618Gln)

TGCAGCTAGCCAGTTTCTTTC′]

2454
NM_000255.3(MUT): c.842T > C
4594
MUT
[′GCCATTCTGGAGCTGGCCTATACTTYAGCAG

(p.Leu281Ser)

ATGGATTGGAGTACTCTAGA′]

2455
NM_000277.1(PAH): c.2T > C
5053
PAH
[′AGACCTCACTCCCGGGGAGCCAGCABGTCC

(p.Met1Thr)

ACTGCGGTCCTGGAAAACCCA′]

2456
NM_000017.3(ACADS):
35
ACADS
[′GGCAGCCATGGCCAAGCTGGCCGCCYCGGA

c.1057T > C (p.Ser353Pro)

GGCCGCGACCGCCATCAGCCA′]

2457
NM_002225.3(IVD):
3712
IVD
[′GCGTATTGGGCATCACAGCCCCTGGYGAGT

c.295 + 2T > C

ATAGTGTCTTTCCCTAAAAAG′]

2458
NM_000030.2(AGXT): c.2T > C
189
AGXT
[′CGAGCGGCAGGTTGGGTGCGGACCAYGGCC

(p.Met1Thr)

TCTCACAAGCTGCTGGTGACC′]

2459
NM_000030.2(AGXT): c.77T > C
189
AGXT
[′CTCTCCATCCCCAACCAGCTCCTGCYGGGGC

(p.Leu26Pro)

CTGGTCCTTCCAACCTGCCT′]

2460
NM_000030.2(AGXT): c.449T > C
189
AGXT
[′GGCCTGGCCCAGCACAAGCCAGTGCYGCTG

(p.Leu150Pro)

TTCTTAACCCACGGGGAGTCG′]

2461
NM_000030.2(AGXT): c.497T > C
189
AGXT
[′TCGTCCACCGGCGTGCTGCAGCCCCHTGATG

(p.Leu166Pro)

GCTTCGGGGAACTCTGCCAC′]

2462
NM_000030.2(AGXT): c.661T > C
189
AGXT
[′CGCCCCTCCAGGGACCTCGCTCATCYCCTTC

(p.Ser221Pro)

AGTGACAAGGCCAAGTGAGT′]

2463
NM_000030.2(AGXT): c.757T > C
189
AGXT
[′CAAGTGGCTGGCCAACTTCTGGGGCYGTGA

(p.Cys253Arg)

CGACCAGCCCAGGATGTGAGG′]

2464
NM_000030.2(AGXT): c.806T > C
189
AGXT
[′CATCACACAATCCCCGTCATCAGCCYGTACA

(p.Leu269Pro)

GCCTGAGAGAGAGCCTGGCC′]

2465
NM_000030.2(AGXT): c.851T > C
189
AGXT
[′CCAGCGCCATCTCCCACACAGGGCCYGGAG

(p.Leu284Pro)

AACAGCTGGCGCCAGCACCGC′]

2466
NM_000030.2(AGXT): c.893T > C
189
AGXT
[′CAGCACCGCGAGGCCGCGGCGTATCYGCAT

(p.Leu298Pro)

GGGCGCCTGCAGGCACTGGGG′]

2467
NM_000030.2(AGXT): c.947T > C
189
AGXT
[′TGAGCCAGGCCCCTCCTGCAGGCGCYCCGG

(p.Leu316Pro)

CTTCCCACAGTCACCACTGTG′]

2468
NM_000030.2(AGXT): c.1076T >
189
AGXT
[′AGCCCGCCCTGTGCCCCCCAGGTGCYGCGG

C (p.Leu359Pro)

ATCGGCCTGCTGGGCTGCAAT′]

2469
NM_000030.2(AGXT): c.1151T >
189
AGXT
[′GTGACGGAGGCCCTGAGGGCGGCCCYGCAG

C (p.Leu384Pro)

CACTGCCCCAAGAAGAAGCTG′]

2470
NM_012203.1(GRHPR): c.203T >
9380
GRHPR
[′TCCGACCACGTGGACAAGAGGATCCYGGAT

C (p.Leu68Pro)

GCTGCAGGTGCACACTGGGTG′]

2471
NM_012203.1(GRHPR): c.965T >
9380
GRHPR
[′CTGGCTGGCCTGAGAGGGGAGCCGABGCCT

C (p.Met322Thr)

AGTGAACTCAAGCTGTAGCCA′]

2472
NM_138413.3(HOGA1): c.533T >
112817
HOGA1
[′GTCCCAGCCAACACAGGGCTGGACCYGCCT

C (p.Leu178Pro)

GTGGATGCAGTGGTCACGCTT′]

2473
NM_138413.3(HOGA1): c.875T >
112817
HOGA1
[′GGGATCCCAGGGCTGAAGAAAATCAYGGAC

C (p.Met292Thr)

TGGTTTGGCTACTATGGAGGC′]

2474
NM_004370.5(COL12A1):
1303
COL12A1
[′TTCTTGACTGATGCCTCCTGGAGCAYTGGGG

1c.700T > C (p.Ile2334Thr)

ACGATAATTTTAACAAAGTT′]

2475
NM_019074.3(DLL4): c.583T > C
54567
DLL4
[′CCTGTGCAAGAAGCGCAATGACCACYTCGG

(p.Phe195Leu)

CCACTATGTGTGCCAGCCAGA′]

2476
NM_019074.3(DLL4): c.1168T >
54567
DLL4
[′CCAGGGGGCCAACTATGCTTGTGAAYGTCC

C (p.Cys390Arg)

CCCCAACTTCACCGGCTCCAA′]

2477
NM_015909.3(NBAS): c.3164T >
51594
NBAS
[′TCAGAGCTTTTGGAAAAACATGGACYCGAG

C (p.Leu1055Pro)

AAACCAATTTCATTTGTTAAA′]

2478
NM_000263.3(NAGLU):
4669
NAGLU
[′GCCTCCTTCCAGGGCCAGCCCTTCAYCTGGT

c.1208T > C (p.Ile403Thr)

GCATGCTGCACAACTTTGGG′]

2479
NM_203290.2(POLRIC):
9533
POLRIC
[′TCTACAGTTTCGTCTCCAGGTCAGAYGCACT

c.436T > C (p.Cys146Arg)

CGGAACCCCCATGCTGCTAA′]

2480
NM_018359.3(UFSP2): c.868T >
−1
—
[′CCAGGGCATATATGGCTATCATCATYATATG

C (p.Tyr290His)

CAGGATCGCATAGATGACAA′]

2481
NM_000310.3(PPT1): c.2T > C
5538
PPT1
[′CCGCGGTCATGTGACACAGCGAAGAYGGCG

(p.Met1Thr)

TCGCCCGGCTGCCTGTGGCTC′]

2482
NM_021007.2(SCN2A):
6326
SCN2A
[′CTAATAAATTTGATCTTGGCTGTGGYGGCCA

c.1271T > C (p. Val424Ala)

TGGCCTATGAGGAACAGAAT′]

2483
NM_021007.2(SCN2A):
6326
SCN2A
[′GTTGACCTGGCCATCACCATCTGCAYTGTCT

c.2306T > C (p.Ile769Thr)

TAAATACACTCTTCATGGCT′]

2484
NM_021007.2(SCN2A):
6326
SCN2A
[′TATGCAGCTGTTGATTCACGAAATGYAAGTC

c.4308 + 2T > C

TAGTTAGAGGGAAATTGTTT′]

2485
NM_021007.2(SCN2A):
6326
SCN2A
[′TGGATTAATCTGGTGTTTATTGTTCYGTTCA

c.4718T > C (p.Leu1573Pro)

CTGGAGAATGTGTGCTGAAA′]

2486
NM_001165963.1(SCN1A):
−1
—
[′CAGCTCATTGCCATGGATTTGCCCAHGGTGA

c.5567T > C (p.Met1856Thr)

GTGGTGACCGGATCCACTGT′]

2487
NM_001165963.1(SCN1A):
6323
SCN1A
[′AATCCCAATTATGGCTACACAAGCTYTGATA

c.1094T > C (p.Phe365Ser)

CCTTCAGTTGGGCTTTTTTG′]

2488
NM_001165963.1(SCN1A):
6323
SCN1A
[′TCGGCATTGAGAACATTCAGAGTTCYCCGA

c.662T > C (p.Leu221Pro)

GCATTGAAGACGATTTCAGTC′]

2489
NM_000806.5(GABRA1):
2554
GABRA1
[′ATTCAAACATACCTGCCATGCATAAYGACA

c.788T > C (p.Met263Thr)

GTGATTCTCTCACAAGTCTCC′]

2490
NM_014191.3(SCN8A):
6334
SCN8A
[′GCCCGTATTGGGCGCATCTTGCGTCYGATCA

c.4889T > C (p.Leu1630Pro)

AAGGCGCCAAAGGGATTCGT′]

2491
NM_005249.4(FOXG1): c.673T >
2290
FOXG1
[′TTACTACCGCGAGAACAAGCAGGGCYGGCA

C (p.Trp225Arg)

GAACTCCATCCGCCACAATCT′]

2492
NM_017882.2(CLN6):
54982
CLN6
[′AAGAATCTCAAGCCGGAGACGCTGGYGAGG

c.486 + 2T > C

CCACCTCCTGCTCCCTGCCTG′]

2493
NM_002693.2(POLG): c.1808T >
5428
POLG
[′AGGGAAGCCATCCCAGGTAAGTGCCRTGAG

C (p.Met603Thr)

TTTAGGTGTGACCCGCATCTG′]

2494
NM_002693.2(POLG): c.1283T >
5428
POLG
[′AGGCAGGTAGGAGACACCCATCTCCRGCAT

C (p.Leu428Pro)

GCCGGCCAGAGTCACTGGGTG′]

2495
NM_018129.3(PNPO): c.2T > C
55163
PNPO
[′GGGTCACGTGGCCGGCGGCCCCCCAYGACG

(p.Met1Thr)

TGCTGGCTGCGGGGCGTCACG′]

2496
NM_007254.3(PNKP):
11284
PNKP
[′ACCCCCACCCCCGCCCCAGGGCCTCRCCGGA

c.1029 + 2T > C

TCAAAGGCTGGGAGCTCGAA′]

2497
NM_172107.2(KCNQ2): c.583T >
3785
KCNQ2
[′CTCCCAGGGCAACGTCTTTGCCACAYCTGCG

C (p.Ser195Pro)

CTCCGGAGCCTGCGCTTCCT′]

2498
NM_000026.2(ADSL): c.340T > C
158
ADSL
[′TATTCACCTTGGTGCTACTTCTTGCYATGTTG

(p.Tyr114His)

GAGACAATACTGTAGGCGC′]

2499
NM_000026.2(ADSL): c.1339T >
158
ADSL
[′CCAGTTGGATCATTTACTGGATCCTYCTTCT

C (p.Ser447Pro)

TTCACTGGTCGTGCCTCCCA′]

2500
NM_001356.4(DDX3X): c.704T >
1654
DDX3X
[′GGGTCTGGAAAAACTGCAGCATTTCYGTTGC

C (p.Leu235Pro)

CCATCTTGAGTCAGATTTAT′]

2501
NM_001356.4(DDX3X):
1654
DDX3X
[′TAAAAATTTTTTTTCTTTCAGATGCYGGCTC

c.1175T > C (p.Leu392Pro)

GTGATTTCTTAGATGAATAT′]

2502
NM_001356.4(DDX3X):
1654
DDX3X
[′GACATTTCAAATGTGAAACATGTTAYCAATT

c.1541T > C (p.Ile514Thr)

TTGACTTGCCAAGTGATATT′]

2503
NM_020533.2(MCOLN1):
57192
MCOLN1
[′ACCATCGCCTTCCGACACCTCTTCCYGCTGG

c.317T > C (p.Leu106Pro)

GCTACTCGGACGGAGCGGAT′]

2504
NM_020533.2(MCOLN1):
57192
MCOLNI
[′TACTGCTTCTGTGGCTGGATCGTGCYGGGGC

c.1340T > C (p.Leu447Pro)

CCTATCATGTGAAGGTACAT′]

2505
NM_000083.2(CLCN1):
1180
CLCN1
[′CCCCGCGAAGCCATCAGTACTTTGTYTGACA

c.1283T > C (p.Phe428Ser)

ACAATACATGGGTGAAACAC′]

2506
NM_003995.3(NPR2): c.226T > C
4882
NPR2
[′CAGCTCCGAACTGGAAGGCGCCTGCYCTGA

(p.Ser76Pro)

GTACCTGGCACCGCTGAGCGC′]

2507
NM_004700.3(KCNQ4): c.808T >
9132
KCNQ4
[′GGACGCCAACTCCGACTTCTCCTCCYACGCC

C (p.Tyr270His)

GACTCGCTCTGGTGGGGGAC′]

2508
NM_004700.3(KCNQ4): c.823T >
9132
KCNQ4
[′CTTCTCCTCCTACGCCGACTCGCTCYGGTGG

C (p.Trp275Arg)

GGGACGGTGCGTGAGGGTCT′]

2509
NM_005097.3(LGI1): c.124T > C
9211
LGI1
[′GGGGAAGAAACCAGCGAAGCCAAAABGCCC

(p.Cys42Arg)

TGCCGTGTGTACTTGTACCAA′]

2510
NM_005572.3(LMNA):
4000
LMNA
[′CAGCTCAGCCAGCTCCAGAAGCAGGYGATA

c.936 + 2T > C

CCCCACCTCACCCCTCTCTCC′]

2511
NM_006009.3(TUBA1A):
7846
TUBA1A
[′AAACGTGCCTTTGTTCACTGGTACGYTGGGG

c.1226T > C (p. Val409Ala)

AGGGGATGGAGGAAGGTGAG′]

2512
NM_001081550.1(THOC2):
57187
THOC2
[′GACGTGTTCAATATGTTCTGTTACCYTGGTC

c.1313T > C (p.Leu438Pro)

CTCACCTTTCTCACGATCCC′]

2513
NM_001081550.1(THOC2):
57187
THOC2
[′ACATCAACAGAAAACTCCAAATTTTYCCAC

c.3034T > C (p.Ser1012Pro)

ACTTCTTTGCTATGATCGAGT′]

2514
NM_001081550.1(THOC2):
57187
THOC2
[′GATTATATAAAGCGAGTGCCTTCAAYTGATG

c.2399T > C (p.Ile800Thr)

TACTCTGTAATGAATTTCAT′]

2515
NM_001356.4(DDX3X):
1654
DDX3X
[′CAGGTAGCAGCAAGAGGACTGGACAYTTCA

c.1520T > C (p.Ile507Thr)

AATGTGAAACATGTTATCAAT′]

2516
NM_000158.3(GBE1):
2632
GBE1
[′TGAATAAAAATCACAGTTATTACTTRCCAAG

c.691 + 2T > C

GCCTTTGATTCTTGGTAGTA′]

2517
NM_000719.6(CACNA1C):
775
CACNA1C
[′ATGAACATCTTCGTGGGCTTCGTCAYCGTCA

c.3497T > C (p.Ile1166Thr)

CCTTTCAGGAGCAGGGGGAG′]

2518
NM_001105.4(ACVR1): c.587T >
90
ACVR1
[′TGTACATCAGGAAGTGGCTCTGGTCYTCCTT

C (p.Leu196Pro)

TTCTGGTACAAAGAACAGTG′]

2519
NM_024531.4(SLC52A2):
79581
SLC52A2
[′CCCTACGGGCGTCTGGCCTACCACCYGGCTG

c.935T > C (p.Leu312Pro)

TGGTGCTGGGCAGTGCTGCC′]

2520
NM_033409.3(SLC52A3):
113278
SLC52A3
[′AGCTGCCTTTCCGAAGTGCCCATCAYCTTCA

c.224T > C (p.Ile75Thr)

CCCTGCTGGGCGTGGGAACC′]

2521
NM_033409.3(SLC52A3):
113278
SLC52A3
[′GGTCTGCGTCTTCGGAATGGGCTCCYGGGTG

c.49T > C (p.Trp17Arg)

ACCATCAATGGGCTCTGGGT′]

2522
NM_133433.3(NIPBL):
25836
NIPBL
[′CCATACCTTACCACTAAATGTAGTGYAAGTA

c.6108 + 2T > C

TAGAGCTGTCTTATTCTTGT′]

2523
NM_002397.4(MEF2C): c.2T > C
4208
MEF2C
[′CGTAATCTGAATCTTTTTTCTCCCCDTAGTCC

(p.Met1Thr)

CCGTTTTTCTTCTCTCTCT′]

2524
NM_000124.3(ERCC6):
2074
ERCC6
[′AATACTCGCTGACCCTGCTTGTGCCRTATTT

c.2551T> C (p.Trp851Arg)

TCAACAAAGACTCAACAACA′]

2525
NM_000208.2(INSR):
3643
INSR
[′GTTCATGCTGTTCTACAAAGAGGCGYAAGT

c.1610 + 2T > C

AGAAGAGTTAGAGAGACGCTG′]

2526
NM_000071.2(CBS): c.325T > C
875
CBS
[′CTCCCGCCCGCGTTGAAGAACTCACRCTTGG

(p.Cys109Arg)

CCACTGGGAGGCAGAGATGA′]

2527
NM_004550.4(NDUFS2):
4720
NDUFS2
[′CATTATGCTCTCCACAGTGGAGTGAYGCTTC

c.875T> C (p.Met292Thr)

GGGGCTCAGGCATCCAGTGG′]

2528
NM_003119.3(SPG7): c.2228T >
6687
SPG7
[′AAGGAAGTGATAAACTATGAGGACAYTGAG

C (p.Ile743Thr)

GCTCTCATTGGCCCGCCGCCC′]

2529
NM_000546.5(TP53): c.584T > C
7157
TP53
[′CACACGCAAATTTCCTTCCACTCGGRTAAGA

(p.Ile195Thr)

TGCTGAGGAGGGGCCAGACC′]

2530
NM_018972.2(GDAP1): c.347T >
54332
GDAP1
[′AGGTTAATGCCTGATAAAGAAAGCAKGTAT

C (p.Met116Thr)

TACCCACGGGTACAACATTAC′]

2531
NM_000070.2(CAPN3): c.566T >
825
CAPN3
[′TGCCTGCCAACGTACAACAATCAACYGGTTT

C (p.Leu189Pro)

TCACCAAGTCCAACCACCGC′]

2532
NM_000070.2(CAPN3):
825
CAPN3
[′TTAATTCCTCCATTTTCCCACCAGAYGGAAG

c.1117T > C (p.Trp373Arg)

GACTGGAGCTTTGTGGACAA′]

2533
NM_181534.3(KRT25): c.950T >
147183
KRT25
[′AAATTGTTCTTTTCATACCGTGGCTRGGAGA

C (p.Leu317Pro)

GACTGAAGTTCAATTTCCAG′]

2534
NM_001002294.2(FMO3):
2328
FMO3
[′CCAGGTGTATTCAATGGAAAGCGTGBCCTG

c.560T > C (p. Val187Ala)

GTGGTTGGCCTGGGGAATTCG′]

2535
NM_001080522.2(CC2D2A):
57545
CC2D2A
[′GAAATTCAAGCTGAAATAAGTGAACYGTTA

c.1676T > C (p.Leu559Pro)

GAAGAGCACACGGAGGAGTAC′]

2536
NM_001080522.2(CC2D2A):
57545
CC2D2A
[′TACCAAGTCATATTTTCTTCACAGAYTGATG

c.3596T > C (p.Ile1199Thr)

GAACATTTAAAATAGATATT′]

2537
NM_025114.3(CEP290):
80184
CEP290
[′CCTGTAACAAATGTATTAAATATTCRTTCTG

c.2343T > C (p.Asn781=)

AGAATTAATGATACTGGCAC′]

2538
NM_030578.3(B9D2): c.107T > C
80776
B9D2
[′CGTTTGGCCCTCCCGCACGCCTGACRGGAGC

(p.Leu36Pro)

TTCCATGCCGCCCCTGCAGT′]

2539
NM_004304.4(ALK): c.3520T > C
238
ALK
[′ACATCCCTCTCTGCTCTGCAGCAAAKTCAAC

(p.Phe1174Leu)

CACCAGAACATTGTTCGCTG′]

TABLE 7

Diseases/disorders containging A to G Changes. The table includes human gene

mutations that may be corrected by changing a guanine (G) to adenine (A). The gene name,

gene symbol,and Gene ID are indicated.

SEQ

ID

Gene
Gene

NO:
Name
ID
Symbol
Flanks

3144
NM_017547.3(FOXRED1):
55572
FOXRED1
[′GTGGGCCCCCACCCGCTAGTTGTCAVCATG

c.1289A > G (p.Asn430Ser)

TACTTTGCTACTGGCTTCAGT′]

3145
NM_001006657.1(WDR35):
57539
WDR35
[′CTAGTGCGGCTGTGGTTGCTTTTTCVGATT

c.25 − 2A > G

TCCATTCCCAATAACGTGAAG′]

3146
NM_001006657.1(WDR35):
57539
WDR35
[′TATGTTTTCAGAAACTTGGATCCTGRGGTA

c.1877A > G (p.Glu626Gly)

AAAACAAGAAATGAGTGTTAA′]

3147
NM_000374.4(UROD):
7389
UROD
[′GGCAACCTGGACCCCTGTGCCTTGTRTGCA

c.932A > G (p.Tyr311Cys)

TCTGAGGTAACAGCCAGGGCC′]

3148
NM_004315.4(ASAH1):
427
ASAH1
[′ACAGAGGACTGCAGAAAATCAACCTRTCC

c.155A > G (p.Tyr52Cys)

TCCTTCAGGACCAACGTGAGTA′]

3149
NM_004315.4(ASAH1):
427
ASAH1
[′GGGTAGATGGTATGTGGTACAAACARATT

c.1006A > G (p.Asn336Asp)

ATGACCGTTGGAAACATCCCTT′]

3150
NM_000071.2(CBS): c.1150A > G
875
CBS
[′GGTGACTCCCCCATCCCGCAGGACCRAGTT

(p.Lys384Glu)

CCTGAGCGACAGGTGGATGCT′]

3151
NM_000274.3(OAT): c.734A > G
4942
OAT
[′GGCGTTGTTGTTCCGGATCCAGGTTRCCTA

(p.Tyr245Cys)

ATGGGAGTGCGAGAGCTCTGC′]

3152
NM_001385.2(DPYS):
1807
DPYS
[′GATAACTGCACTTTCAACACCTGCCRGAA

c.1001A > G (p.Gln334Arg)

AGCTCTTGGGAAGGATGATTTT′]

3153
NM_024598.3(USB1): c.502A > G
79650
USB1
[′GATTTACACCAATCAAGAGAAAACCRGGT

(p.Arg168Gly)

GGGTCCTCCCAACCCCCAATCA′]

3154
NM_001194958.2(KCNJ18):
100134444
KCNJ18
[′AGTGCGAAGGATCTGGTAGAGAACARGTT

c.1097A > G (p.Lys366Arg)

CCTGCTGCCCAGTGCCAACTCC′]

3155
NM_001914.3(CYB5A):
1528
CYB5A
[′TTTTTATTCTACCTCTCCTTTGAACRGCATC

c.130 − 2A > G

CTGGTGGGGAAGAAGTTTTA′]

3156
NM_000398.6(CYB5R3):
1727
CYB5R3
[′CGCTTCAAGCTCTGGTACACGCTGGRCAG

c.719A > G (p.Asp240Gly)

AGCCCCTGAAGGTGAGTGAGGG′]

3157
NM_004628.4(XPC):
7508
XPC
[′ATTATTATTGTTATTACTATTACTGRTTTTT

c.413 − 24A > G

AAAAATGCTTGTTGATAGAA′]

3158
NM_001134363.2(RBM20):
282996
RBM20
[′TGGCCCAGAAAGGCCGCGGTCTCGTRGTC

c.1909A > G (p.Ser637Gly)

CGGTGAGCCGGTCACTCTCCCC′]

3159
NM_000552.3(VWF): c.2384A > G
7450
VWF
[′GAGTGTACCAAAACGTGCCAGAACTRTGA

(p.Tyr795Cys)

CCTGGAGTGCATGAGCATGGGC′]

3160
NM_000552.3(VWF): c.1583A > G
7450
VWF
[′ACCTGCGGCCTGTGTGGGAATTACARTGG

(p.Asn528Ser)

CAACCAGGGCGACGACTTCCTT′]

3161
NM_144573.3(NEXN): c.1955A > G
91624
NEXN
[′ACTTTCCCAGAAGATGGAGGAGAGTRTAT

(p.Tyr652Cys)

GTGTAAAGCAGTCAACAATAAA′]

3162
NM_000267.3(NF1): c.4267A > G
4763
NF1
[′CGAAAGGGGCTTGAAGTTAATGTCARAGG

(p.Lys1423Glu)

TGAATTATTTTGATAATCTAGC′]

3163
NM_000267.3(NF1):
4763
NF1
[′TCTCTTTGTCTTTCTCTTTTTTAAARAATTC

c.1642 − 8A > G

AGGCTCTGCTGGTTCTTCAT′]

3164
NM_000267.3(NF1): c.1466A > G
4763
NF1
[′CCTACAGACCTGGAGACAAGAAGCTRTAA

(p.Tyr489Cys)

GTATCTTCTCTTGTCCATGGTG′]

3165
NM_000267.3(NF1):
4763
NF1
[′AAAAACATGTTATTTTCCTTCTTCARCTAG

c.5944 − 5A > G

ATTACAGATCTGCTTGATGTT′]

3166
NM_000308.2(CTSA):
5476
CTSA
[′TACCATGGCCTTCTGGGGAACAGGTRTGG

c.746 + 3A > G

GATAGGGCAGTTGGGCAATCTC′]

3167
NM_000308.2(CTSA): c.200A > G
5476
CTSA
[′CTGGCCAAGCAGCCGTCTTTCCGCCRGTAC

(p.Gln67Arg)

TCCGGCTACCTCAAAGGCTCC′]

3168
NM_000308.2(CTSA): c.1238A > G
5476
CTSA
[′CTTTAGAAATACCAGATCCTATTATRTAAT

(p.Tyr413Cys)

GGAGATGTAGACATGGCCTGC′]

3169
NM_000308.2(CTSA): c.1411A > G
5476
CTSA
[′CTCCCACATCGCCTTTCTCACGATCRAGGT

(p.Lys471Glu)

AGGGACTGGGCCTGCTGAGAG′]

3170
NM_000353.2(TAT):
6898
TAT
[′TTCCAAACACAGTAGGGTCCCCTTTYTATG

c.236 − 5A > G

GGAGGAAAACACAAAAGGAGC′]

3171
NM_000097.5(CPOX): c.1210A > G
1371
CPOX
[′TAATCTGCTGTATGATCGGGGCACARAGTT

(p.Lys404Glu)

TGGCCTCTTCACTCCAGGATC′]

3172
NM_000317.2(PTS): c.155A > G
5805
PTS
[′AACAATCCAAATGGCCATGGGCACARTTA

(p.Asn52Ser)

TAAAGGTGAGAGAAAAACTGAT′]

3173
NM_000317.2(PTS): c.139A > G
5805
PTS
[′ACTGTTTGGGAAATGCAACAATCCARATG

(p.Asn47Asp)

GCCATGGGCACAATTATAAAGG′]

3174
NM_000317.2(PTS): c.347A > G
5805
PTS
[′GAAAATGTAGCTGTTTATATCTGGGRCAAC

(p.Asp116Gly)

CTCCAGAAAGTTCTTCCTGTA′]

3175
NM_000320.2(QDPR): c.449A > G
5860
QDPR
[′CCCCATTTCCCAGGTATGATCGGGTRCGGC

(p.Tyr150Cys)

ATGGCCAAGGGTGCTGTTCAC′]

3176
NM_173560.3(RFX6):
222546
RFX6
[′TCTATTTTTCTTTATCATCCCTTCARCTGGC

c.224 − 12A > G

AATCAGAAATGCACTTAAAC′]

3177
NM_001999.3(FBN2):
2201
FBN2
[′TTCATCAATATCTGTGAAAACAGCAYTGC

c.3725 − 15A > G

AACCACATTGTCAGGTCTGCTT′]

3178
NM_001040613.2(TMEM70):
54968
TMEM70
[′GATCCTCTCTCTTTTTTTCCCATTTRGGTGT

c.*7 − 2A > G

GAAATGTTTCTCTTATTCTA′]

3179
NM_152416.3(NDUFAF6):
137682
NDUFAF6
[′AGGGCCTTTAATGTGGAACTGGCTCRGGCT

c.296A > G (p.Gln99Arg)

GGTATTAAGATACCTTAAAAT′]

3180
NM_000140.3(FECH):
2235
FECH
[′ACTAAAACGATTGTAACACTGTAGAYACC

c.1137 + 3A > G

TTAGAGAACAATGGATTTCCAT′]

3181
NM_000277.1(PAH): c.1A > G
5053
PAH
[′GAGACCTCACTCCCGGGGAGCCAGCDTGT

(p.Met1Val)

CCACTGCGGTCCTGGAAAACCC′]

3182
NM_000277.1(PAH): c.611A > G
5053
PAH
[′TCCTTGTATAAAACCCATGCTTGCTRTGAG

(p.Tyr204Cys)

TACAATCACATTTTTCCACTT′]

3183
NM_000277.1(PAH): c.1241A > G
5053
PAH
[′ATACCTCGGCCCTTCTCAGTTCGCTRCGAC

(p.Tyr414Cys)

CCATACACCCAAAGGATTGAG′]

3184
NM_000277.1(PAH): c.662A > G
5053
PAH
[′CTTGAAAAGTACTGTGGCTTCCATGRAGAT

(p.Glu221Gly)

AACATTCCCCAGCTGGAAGAC′]

3185
NM_000277.1(PAH): c.916A > G
5053
PAH
[′TTCTATTTTCCCCCAATTACAGGAARTTGG

(p.Ile306Val)

CCTTGCCTCTCTGGGTGCACC′]

3186
NM_000277.1(PAH): c.1169A > G
5053
PAH
[′TTCCAGCCCCTGTATTACGTGGCAGRGAGT

(p.Glu390Gly)

TTTAATGATGCCAAGGAGAAA′]

3187
NM_000277.1(PAH):
5053
PAH
[′TGTCATCCTTTGGTGAATTACAGGTVTGAC

c.1065 + 3A > G

CTTCACAGGAACCAAGGATAG′]

3188
NM_000277.1(PAH): c.227A > G
5053
PAH
[′AGACCTTCTCGTTTAAAGAAAGATGVGTA

(p.Glu76Gly)

TGAATTTTTCACCCATTTGGAT′]

3189
NM_000130.4(F5): c.1000A > G
2153
F5
[′CATTAAAAACTGCCCAAAGAAAACCRGGA

(p.Arg334Gly)

ATCTTAAGAAAATAACTCGTGA′]

3190
NM_000130.4(F5): c.5189A > G
2153
F5
[′GGCTCTGCCTGTCGGGCTTGGGCCTRCTAC

(p.Tyr1730Cys)

TCAGCTGTGAACCCAGTAGGT′]

3191
NM_000512.4(GALNS):
2588
GALNS
[′TTGGTCCCCGCGCAGCCCCAGCTCARCGTG

c.1460A > G (p.Asn487Ser)

TGCAACTGGGCGGTCATGGTA′]

3192
NM_015702.2(MMADHC):
27249
MMADHC
[′ACTCTTTTTGAAACTGATGAACGCTRCCGA

c.746A > G (p.Tyr249Cys)

CATTTAGGATTCTCTGTTGAT′]

3193
NM_015141.3(GPD1L): c.370A > G
23171
GPD1L
[′TAACTTCTTGGCATCCTTGTAGGGCRTAGA

(p.Ile124Val)

CGAGGGCCCCGAGGGGCTGAA′]

3194
NM_013319.2(UBIAD1):
29914
UBIAD1
[′GTGCACGGGGCCGGTAATTTGGTCARCAC

c.305A > G (p.Asn102Ser)

TTACTATGACTTTTCCAAGGGC′]

3195
NM_013319.2(UBIAD1):
29914
UBIAD1
[′CATTGACCACAAAAAGAGTGATGACRGGA

c.355A > G (p.Arg119Gly)

CACTTGTGGACCGAATCTTGGA′]

3196
NM_013319.2(UBIAD1):
29914
UBIAD1
[′AGCACCGAGGCCATTCTCCATTCCARCAAC

c.695A > G (p.Asn232Ser)

ACCAGGGACATGGAGTCCGAC′]

3197
NM_013319.2(UBIAD1):
29914
UBIAD1
[′TACTATGACTTTTCCAAGGGCATTGRCCAC

c.335A > G (p.Asp112Gly)

AAAAAGAGTGATGACAGGACA′]

3198
NM_000046.3(ARSB): c.629A > G
411
ARSB
[′GTTGCAACAGGATATAAAAATATGTRTTC

(p.Tyr210Cys)

AACAAACATATTCACCAAAAGG′]

3199
NM_006331.7(EMG1): c.257A > G
10436
EMG1
[′CGGGACCCTGGGGAAGCGCGGCCAGRTAT

(p.Asp86Gly)

CACCCACCAGGTAACTCCAGGG′]

3200
NM_000181.3(GUSB): c.1484A > G
2990
GUSB
[′CTGCTGCTCTGGTCCTAGGCTCCGTRTGTG

(p.Tyr495Cys)

GATGTGATCTGTTTGAACAGC′]

3201
NM_000067.2(CA2): c.754A > G
760
CA2
[′CTGGCGCCCAGCTCAGCCACTGAAGRACA

(p.Asn252Asp)

GGCAAATCAAAGCTTCCTTCAA′]

3202
NM_000067.2(CA2): c.52A > G
760
CA2
[′TCCCCCAGGACCTGAGCACTGGCATVAGG

(p.Lys18Glu)

ACTTCCCCATTGCCAAGGGAGA′]

3203
NM_000404.2(GLB1): c.947A > G
2720
GLB1
[′TTTATAGGTGGGACCAATTTTGCCTRTTGG

(p.Tyr316Cys)

AATGGTAAGAGCACTTTAATA′]

3204
NM_000404.2(GLB1): c.1498A > G
2720
GLB1
[′TTTGCAGGGTTTGGTTTCTAACCTGRCTCT

(p.Thr500Ala)

CAGTTCCAATATCCTCACGGA′]

3205
NM_000404.2(GLB1):
2720
GLB1
[′GAGAGTCAGGTTAGAAACCAAACCCYGCA

c.1480 − 2A > G

AAGCAGAAACAGAGCACAGTGA′]

3206
NM_000404.2(GLB1): c.1772A > G
2720
GLB1
[′ATTAATGGCTTTAACCTTGGCCGCTRTTGG

(p.Tyr591Cys)

CCAGCCCGGGGCCCTCAGTTG′]

3207
NM_203447.3(DOCK8):
81704
DOCK8
[′ACTCTGAGCGTTAGCAGCTTTTTCARGCAG

c.1418A > G (p.Lys473Arg)

GTATCTCTTCACATTACAGTG′]

3208
NM_000275.2(OCA2): c.1465A > G
4948
OCA2
[′TGCCACTGCCATCGGGGACCCTCCARATGT

(p.Asn489Asp)

CATTATTGTTTCCAACCAAGA′]

3209
NM_152778.2(MFSD8): c.362A > G
256471
MFSD8
[′ATTTCCGTGGCAGCCAACTGCCTCTVTGCA

(p.Tyr121Cys)

TATCTCCACATCCCAGCTTCT′]

3210
NM_139241.3(FGD4):
121512
FGD4
[′ACTGTTCATTTTTCTTTTAAATTTARGGTGG

c.1762 − 2A > G

TTTGTTGGAAATGCTCCGAC′]

3211
NM_020223.3(FAM20C):
56975
FAM20C
[′TGTGACACTTTCTGCCTCTCTCCGCRGGAA

c.1364 − 2A > G

ACATGGACCGTCACCACTACG′]

3212
NM_138387.3(G6PC3): c.346A > G
92579
G6PC3
[′GGCAGGCAGCCCTTCTGGACACTGCRTGA

(p.Met116Val)

TCACAGGAGCAGCCCTCTGGCC′]

3213
NM_018122.4(DARS2): c.133A > G
55157
DARS2
[′TTTTTTTTTTTTTTTTAAAGAATTCRGTAGC

(p.Ser45Gly)

TTTGTTGTCCGGACCAACAC′]

3214
NM_000642.2(AGL):
178
AGL
[′CATCTTTTATTTAACTTAAATTTCARTCATT

c.4260 − 12A > G

TTGCAGTGATATGGTTTACT′]

3215
NM_000642.2(AGL): c.3439A > G
178
AGL
[′TCTACTGGGTGAAGGAATTTATGCCRGATA

(p.Arg1147Gly)

CAATTGTCGGGATGCTGTGTG′]

3216
NM_145014.2(HYLS1): c.632A > G
−1
—
[′TTAAGCCGAAACCGGGGCAAGACAGRCCG

(p.Asp211Gly)

GGTAGCCCGGTATTTTGAGTAC′]

3217
NM_014362.3(HIBCH): c.365A > G
26275
HIBCH
[′GCTCCAGTTTTCTTCAGAGAAGAATRTATG

(p.Tyr122Cys)

CTGAATAATGCTGTTGGTATG′]

3218
NM_014846.3(KIAA0196):
9897
KIAA0196
[′TTTTCTTATTTCTGTATTACTAGAARACCTT

c.1411A > G (p.Asn471Asp)

CAAGCTTGGTTCAGAGAGAT′]

3219
NM_000505.3(F12): c.158A > G
2161
F12
[′GAGCCCTGCCACTTCCCCTTCCAGTRCCAC

(p.Tyr53Cys)

CGGCAGCTGTACCACAAATGT′]

3220
NM_001029871.3(RSPO4):
343637
RSPO4
[′TTCATCCGCCGGGAAGGCATCCGCCRGTA

c.194A > G (p.Gln65Arg)

CGGCAAGTGCCTGCACGACTGT′]

3221
NM_017654.3(SAMD9):
54809
SAMD9
[′TAAAAGACTGGAAAGACTTGTTCACRAAG

c.4483A > G (p.Lys1495Glu)

GAAAAATTGACCAGTGCTTTAA′]

3222
NM_152419.2(HGSNAT):
138050
HGSNAT
[′TGTCTTAATTTTACCTAATGTTTGTRGGTTG

c.372 − 2A > G

GAATACAGATTTGGAGAATT′]

3223
NM_001174089.1(SLC4A11):
83959
SLC4A11
[′CATGAGCTCCCTGCCCTACATGAAGRTGAT

c.2518A > G (p.Met840Val)

CTTTCCCCTCATCATGATCGC′]

3224
NM_012073.4(CCT5): c.440A > G
22948
CCT5
[′CAGGCTGCTCGTGTTGCTATTGAACRCCTG

(p.His147Arg)

GACAAGATCAGCGATAGCGTC′]

3225
NM_025114.3(CEP290):
80184
CEP290
[′CACCTGGCCCCAGTTGTAATTGTGARTATC

c.2991 + 1655A > G

TCATACCTATCCCTATTGGCA′]

3226
NM_153704.5(TMEM67):
91147
TMEM67
[′TATTAAAACAGTTGTAACTGTTTATRGGAG

c.870 − 2A > G

ACAGAATCTTCCTTGGCTGTT′]

3227
NM_153704.5(TMEM67):
91147
TMEM67
[′TATCAGGTTTCTTTCTCAGTCACATDTGAA

c.1538A > G (p.Tyr513Cys)

ATGGATCATGGAGAAGCACAT′]

3228
NM_001041.3(SI): c.350A > G
6476
SI
[′GTTGATAATCATGGTTATAACGTTCRAGAC

(p.Gln117Arg)

ATGACAACAACAAGTATTGGT′]

3229
NM_015697.7(COQ2): c.890A > G
27235
COQ2
[′TCTGGAGTTATGTGGACACTAATATRTGAT

(p.Tyr297Cys)

ACTATTTATGCCCATCAGGTA′]

3230
NM_015697.7(COQ2): c.683A > G
27235
COQ2
[′GCACTGGGTGTTCTTCTGTGTCTAARTTAC

(p.Asn228Ser)

TACAGGTATATTAAACGTTTT′]

3231
NM_000190.3(HMBS): c.1A > G
3145
HMBS
[′CACAGCCTACTTTCCAAGCGGAGCCRTGTC

(p.Met1Val)

TGGTAACGGCAATGCGGCTGC′]

3232
NM_004035.6(ACOX1): c.832A > G
51
ACOX1
[′GAGTAACAAGCTGACTTACGGGACCRTGG

(p.Met278Val)

TGTTTGTCAGGTCCTTCCTTGT′]

3233
NM_004035.6(ACOX1): c.926A > G
51
ACOX1
[′ATCCGATACAGCGCTGTGAGGCACCRGTC

(p.Gln309Arg)

TGAAATCAAGCCAGGGTAAGGA′]

3234
NM_000237.2(LPL): c.548A > G
4023
LPL
[′TGCTTTTTTCCCTTTTAAGGCCTCGRTCCAG

(p.Asp183Gly)

CTGGACCTAACTTTGAGTAT′]

3235
NM_000237.2(LPL): c.953A > G
4023
LPL
[′TGCAACAATCTGGGCTATGAGATCARTAA

(p.Asn318Ser)

AGTCAGAGCCAAAAGAAGCAGC′]

3236
NM_001171993.1(HPD):
3242
HPD
[′TACATCGGCCAATTCTTGCCTGGATRTGAG

c.362A > G (p.Tyr121Cys)

GCCCCAGCGTTCATGGACCCC′]

3237
NM_139281.2(WDR36):
134430
WDR36
[′CTTCTTGTCACAAATGGCGCTGACARTGCT

c.1064A > G (p.Asn355Ser)

CTTAGGGTATTATGATTATTG′]

3238
NM_001127255.1(NLRP7):
−1
——
[′CTCACAAACCTGGACTTGAGTATCARCCA

Ac.2738 > G (p.Asn913Ser)

GATAGCTCGTGGATTGTGGATT′]

3239
NM_016417.2(GLRX5): c.294A > G
51218
GLRX5
[′TGCTGGACGACCCGGAGCTCCGACARGGT

(p.Gln98=)

CAGGCCAGTGTGCCGGGCAGGC′]

3240
NM_024884.2(L2HGDH): c.293A >
79944
L2HGDH
[′ACTGGACATAACAGTGGTGTCATACRTAG

G (p.His98Arg)

TGGAATTTATTATAAACCTGAG′]

3241
NM_000382.2(ALDH3A2):
224
ALDH3A2
[′ACATCCAGTGGAGGTGTCACAGGCARTGA

c.1157A > G (p.Asn386Ser)

CGTCATTATGCACTTCACGCTC′]

3242
NM_018105.2(THAP1): c.266A > G
55145
THAP1
[′TTTCTTTGTACTGAGCCACATGACARGGTA

(p.Lys89Arg)

ATATGCATTTTAAAATATTGG′]

3243
NM_000785.3(CYP27B1):
1594
CYP27B1
[′GCCCTGGTTCGGGACGTGGCGGGGGRATT

c.566A > G (p.Glu189Gly)

TTACAAGTTCGGACTGGAAGGT′]

3244
NM_182548.3(LHFPL5):
222662
LHFPL5
[′TTCATCTGCAACACGGCCACAGTCTRTAAG

c.380A > G(p.Tyr127Cys)

ATCTGTGCATGGATGCAGCTG′]

3245
NM_015040.3(PIKFYVE):
200576
PIKFYVE
[′TTCAAAGAAATGGAGAACAGGAGGARGA

c.3308A > G (p.Lys1103Arg)

AACAGCTGCTCAGGGATCTCTCT′]

3246
NM_138701.3(MPLKIP):
136647
MPLKIP
[′GTTGGAAAATTATTTCAAGCCTTCARTGCT

c.430A > G (p.Met144Val)

TGAAGATCCTTGGGCTGGCCT′]

3247
NM_152783.4(D2HGDH):
728294
D2HGDH
[′TGCCCTTGTCCCTCCAGGAGATGGTRACCT

c.1315A > G (p.Asn439Asp)

GCACCTCAATGTGACGGCGGA′]

3248
NM_022912.2(REEP1):
65055
REEP1
[′AACTTGTGTTTTCATCTCTCTCTCCRGGTTT

c.183 − 2A > G

CCATTCTATTATGAACTAAA′]

3249
NM_000060.3(BTD): c.755A > G
686
BTD
[′ACATGCTTTGATATATTGTTCTTTGRCCCT

(p.Asp252Gly)

GCCATCAGAGTCCTCAGAGAC′]

3250
NM_022132.4(MCCC2):
64087
MCCC2
[′TGTGGCCTGTGCCCAAGTGCCTAAGDTAA

c.1309A > G (p.Ile437Val)

CCCTCATCATTGGGGGCTCCTA′]

3251
NM_022132.4(MCCC2): c.569A > G
64087
MCCC2
[′GCAGATGTGTTTCCAGATCGAGACCRCTTT

(p.His190Arg)

GGCCGTACATTCTATAATCAG′]

3252
NM_198578.3(LRRK2):
120892
LRRK2
[′ATCATCCGACTATATGAAATGCCTTRTTTT

c.5096A > G (p.Tyr1699Cys)

CCAATGGGATTTTGGTCAAGA′]

3253
NM_198578.3(LRRK2):
120892
LRRK2
[′TGTGACTAGAAATAAAATATCAGGGRTAT

c.3364A > G(p.Ile1122Val)

GCTCCCCCTTGAGACTGAAGGA′]

3254
NM_000022.2(ADA):
100
ADA
[′TTCCCAACCCCTTTCTTCCCTTCCCRGGGG

c.219 − 2A > G

CTGCCGGGAGGCTATCAAAAG′]

3255
NM_000022.2(ADA): c.290A > G
100
ADA
[′ATGAAGGCCAAAGAGGGCGTGGTGTDTGT

(p.Tyr97Cys)

GGAGGTGCGGTACAGTCCGCAC′]

3256
NM_017780.3(CHD7): c.3082A > G
55636
CHD7
[′TTTAGTAATTGCCCCATTGTCCACARTCCC

(p.Ile1028Val)

CAACTGGGAAAGGGAATTCCG′]

3257
NM_017780.3(CHD7): c.164A > G
55636
CHD7
[′TTTGCCTCTTTACAGCCATCCCTTCRTCATC

(p.His55Arg)

CTTCAACTAATCAAAATCAA′]

3258
NM_152443.2(RDH12): c.677A > G
145226
RDH12
[′GTCCCAGGCACCGGGGTCACCACCTRCGC

(p.Tyr226Cys)

AGTGCACCCAGGCGTCGTCCGC′]

3259
NM_015335.4(MED13L):
23389
MED13L
[′TACCCGATGGTGCTAAAAAAGAAAGRAGA

c.752A > G (p.Glu251Gly)

ATCGAAAGAGGAAGACGAGTTG′]

3260
NM_015335.4(MED13L):
23389
MED13L
[′GCTTTTTTTCCCCCCTTCCCTCTAGRTGATA

c.6068A > G (p.Asp2023Gly)

TGTTTGTTGACCTTCCATTC′]

3261
NM_025265.3(TSEN2): c.926A > G
80746
TSEN2
[′TATTTTCAGGCCTTTTTCTTGGTCTRTGCTC

(p.Tyr309Cys)

TGGGATGTTTAAGTATTTAC′]

3262
NM_015384.4(NIPBL):
25836
NIPBL
[′AAAACAGACGTGACTATGCTCTTGTRTATA

c.7289A > G (p.Tyr2430Cys)

GCAGACAATCTAGCCTGTTTT′]

3263
NM_207352.3(CYP4V2):
285440
CYP4V2
[′GTCATCTTATCTACTTGCTTTCATCRGGGA

c.1091 − 2A > G

AGTCTGACCGTCCCGCTACAG′]

3264
NM_024006.5(VKORC1):
79001
VKORC1
[′CAGCTGTTCGCGCGTCTTCTCCTCCRGGTG

c.172A >G (p.Arg58Gly)

TGCACGGGAGTGGGAGGCGTG′]

3265
NM_000551.3(VHL): c.491A > G
7428
VHL
[′TATACTCTGAAAGAGCGATGCCTCCRGGTT

(p.Gln164Arg)

GTCCGGAGCCTAGTCAAGCCT′]

3266
NM_000101.3(CYBA): c.281A > G
1535
CYBA
[′AATTACTATGTTCGGGCCGTCCTGCRTCTC

(p.His94Arg)

CTGTGAGTCCCCGTCCCGCAC′]

3267
NM_014874.3(MFN2): c.827A > G
9927
MFN2
[′TTGTTTGGGCTCCAGGTGCGGCGGCRGCAC

(p.Gln276Arg)

ATGGAGCGTTGTACCAGCTTC′]

3268
NM_015046.5(SETX): c.1807A > G
23064
SETX
[′GCAGAAGTCAGATCCACAAAAGTGTYACA

(p.Asn603Asp)

TGGAGGTGCTTTGAATTTTATG′]

3269
NM_005609.2(PYGM): c.1A > G
5837
PYGM
[′CAGTCCGGCCCGCCCTCCTGCAGCCVTGTC

(p.Met1Val)

CCGGCCCCTGTCAGACCAAGA′]

3270
NM_033071.3(SYNE1):
23345
SYNE1
[′ACTTCACTTCTGTTTTATCCCTGTARTGTTT

c.15705 − 12A > G

CTGAAGCATGCAGGAGAAAG′]

3271
NM_130468.3(CHST14):
113189
CHST14
[′CTGTGCCAGCCTTGTGCCGTGCACTRTGAC

c.878A > G (p.Tyr293Cys)

TTTGTGGGCTCCTATGAGAGG′]

3272
NM_206933.2(USH2A):
7399
USH2A
[′AAAAGTTTTGTATTACGAATTATACRGAAG

c.14020A > G (p.Arg4674Gly)

ACAAATAGCAACTCAGCCTAG′]

3273
NM_000048.3(ASL): c.857A > G
435
ASL
[′AGCACGGGAAGCAGCCTGATGCCCCRGAA

(p.Gln286Arg)

GAAAAACCCCGACAGTTTGGAG′]

3274
NM_001875.4(CPS1): c.1010A > G
1373
CPS1
[′CAGGCTTTCATTACTGCTCAGAATCRTGGC

(p.His337Arg)

TATGCCTTGGACAACACCCTC′]

3275
NM_001173464.1(KIF21A):
55605
KIF21A
[′GACCATTTCCAACATGGAGGCAGATRTGA

c.2839A > G (p.Met947Val)

ATAGACTCCTCAAGGTGTGGAA′]

3276
NM_000026.2(ADSL): c.736A > G
158
ADSL
[′CATCACAGGGCAGACATATACACGARAAG

(p.Lys246Glu)

TGGATATTGAAGTACTGTCTGT′]

3277
NM_024577.3(SH3TC2):
79628
SH3TC2
[′AGCCATTGCTTTTCTCATTATCCACRGGCC

c.530 − 2A > G

ACTTCTTCTGCAGAGCCCTGT′]

3278
NM_018249.5(CDK5RAP2):
55755
CDK5RAP
[′AGCATGGGAGATGATTTATCTTTCARTCTC

c.4005 − 15A > G

2
AATGGTTAAGGATTGAGGAAG′]

3279
NM_000346.3(SOX9): c.517A > G
6662
SOX9
[′GCACAAGAAGGACCACCCGGATTACRAGT

(p.Lys173Glu)

ACCAGCCGCGGCGGAGGAAGTC′]

3280
NM_144596.3(TTC8):
123016
TTC8
[′GTTTACTGCCTTCTTAATGCTTTCCRGGAA

c.115 − 2A > G

CCAGATCCTGAATTGCCAGTG′]

3281
NM_000243.2(MEFV): c.2080A > G
4210
MEFV
[′GAATGGCTACTGGGTGGTGATAATGDTGA

(p.Met694Val)

AGGAAAATGAGTACCAGGCGTC′]

3282
NM_000243.2(MEFV): c.2084A > G
4210
MEFV
[′GGCTACTGGGTGGTGATAATGATGADGGA

(p.Lys695Arg)

AAATGAGTACCAGGCGTCCAGC′]

3283
NM_006493.2(CLN5): c.1121A > G
1203
CLN5
[′GTGCACAAACAGTTCTATTTGTTTTRTAAT

(p.Tyr374Cys)

TTTGAATATTGGTTTTTACCT′]

3284
NM_000483.4(APOC2): c.1A > G
−1
—
[′TCAATGTTCCAGGTCTCTGGACACTRTGGG

(p.Met1Val)

CACACGACTCCTCCCAGCTCT′]

3285
NM_058172.5(ANTXR2):
118429
ANTXR2
[′TGGCCAACTGTGGATGCTTCCTATTDTGGT

c.1142A > G (p.Tyr381Cys)

GGTCGAGGGGTTGGAGGAATT′]

3286
NM_001128085.1(ASPA):
−1
—
[′TATAAAATTATAGAGAAAGTTGATTRCCCC

c.692A > G (p.Tyr231Cys)

CGGGATGAAAATGGAGAAATT′]

3287
NM_001128085.1(ASPA):
−1
—
[′ATCTTTGGAGGAACCCATGGGAATGRGCT

c.71A > G (p.Glu24Gly)

AACCGGAGTATTTCTGGTTAAG′]

3288
NM_014365.2(HSPB8): c.421A > G
26353
HSPB8
[′TGGCATTGTTTCTAAGAACTTCACARAGAA

(p.Lys141Glu)

AATCCAGTAAGTAACCTGGAG′]

3289
NM_000391.3(TPP1): c.857A > G
1200
TPP1
[′CAGTACCTGATGAGTGCTGGTGCCARCATC

(p.Asn286Ser)

TCCACCTGGGTCTACAGTAGC′]

3290
NM_000391.3(TPP1):
1200
TPP1
[′TGTCCCTCATGCCGGCCTGGATTTTYTTTTT

c.887 − 10A > G

TTTTTTTTTTGAGGGATGGG′]

3291
NM_182760.3(SUMF1): c.1A > G
285362
SUMF1
[′CGGGTCACATGGCCCGCGGGACAACRTGG

(p.Met1Val)

CTGCGCCCGCACTAGGGCTGGT′]

3292
NM_031443.3(CCM2): c.1A > G
83605
CCM2
[′GGCCGCGGGAGCCGCACGCGGCGATRTGG

(p.Met1Val)

AAGAGGAGGGCAAGAAGGGCAA′]

3293
NM_004183.3(BEST1): c.707A > G
7439
BEST1
[′GACTGGATTAGTATCCCACTGGTGTRTACA

(p.Tyr236Cys)

CAGGTGAGGACTAGGCTGGTG′]

3294
NM_004183.3(BEST1): c.680A > G
7439
BEST1
[′ACTCAGTGTGGACACCTGTATGCCTRCGAC

(p.Tyr227Cys)

TGGATTAGTATCCCACTGGTG′]

3295
NM_000158.3(GBE1): c.1634A > G
2632
GBE1
[′TGTAATGCAGGTAATGAATTTGGGCRTCCT

(p.His545Arg)

GAATGGTTAGACTTCCCAAGA′]

3296
NM_000158.3(GBE1): c.1883A > G
2632
GBE1
[′GGTCTTCTTTTCATTTTCAACTTCCRTCCAA

(p.His628Arg)

GCAAGAGCTACACTGACTAC′]

3297
NM_017890.4(VPS13B):
157680
VPS13B
[′CTTCTGCCCTGGGCCCTGCTTATCARTGAA

c.8978A > G (p.Asn2993Ser)

TCCAAATGGGACCTCTGGCTA′]

3298
NM_000019.3(ACAT1): c.278A > G
38
ACAT1
[′GAAGTGAAAGAAGCATACATGGGTARTGT

(p.Asn93Ser)

TCTACAAGGAGGTGAAGGACAA′]

3299
NM_173076.2(ABCA12):
26154
ABCA12
[′CATATTACTTCATTGCTGGGGCCCARTGGA

c.4139A > G (p.Asn1380Ser)

GCTGGGAAAACTACTACCATG′]

3300
NM_030665.3(RAI1): c.4685A > G
10743
RAI1
[′AAGGGGCGTGCCAAGCGACGACGACRGCA

(p.Gln1562Arg)

GCAGGTGCTGCCCCTGGATCCC′]

3301
NM_000271.4(NPC1): c.3467A > G
4864
NPC1
[′AGTCTGAACGCTGTATCCTTGGTCARCCTG

(p.Asn1156Ser)

GTGATGGTGAGTCCTCATACA′]

3302
NM_000271.4(NPC1): c.3263A > G
4864
NPC1
[′CCCTCCAGTGTGTTTTATGTCTTCTRCGAA

(p.Tyr1088Cys)

CAGTACCTGACCATCATTGAC′]

3303
NM_000543.4(SMPD1):
6609
SMPD1
[′CTCCGCCTCATCTCTCTCAATATGARTTTTT

c.1154A > G (p.Asn385Ser)

GTTCCCGTGAGAACTTCTGG′]

3304
NM_000226.3(KRT9): c.469A > G
3857
KRT9
[′TCTGACTGCTAATGAGAAGAGCACCRTGC

(p.Met157Val)

AGGAACTCAATTCTCGGCTGGC′]

3305
NM_000226.3(KRT9): c.482A > G
3857
KRT9
[′GAGAAGAGCACCATGCAGGAACTCADTTC

(p.Asn161Ser)

TCGGCTGGCCTCTTACTTGGAT′]

3306
NM_176824.2(BBS7): c.968A > G
55212
BBS7
[′ACAGGTCTGACAACAGAGCCCATTCRTAA

(p.His323Arg)

GGAAAGTGGACCAGGAGAAGAA′]

3307
NM_000051.3(ATM): c.3118A > G
472
ATM
[′GAGGAAATATATATTCTCTGTAAGARTGG

(p.Met1040Val)

CCCTAGTAAATTGCCTTAAAAC′]

3308
NM_000051.3(ATM): c.7268A > G
472
ATM
[′GCTCTCCTGAAAAGAGCCAAAGAGGRAGT

(p.Glu2423Gly)

AGGTCTCCTTAGGGAACATAAA′]

3309
NM_000051.3(ATM): c.8030A > G
−1
—
[′TATTAGGTGGACCACACAGGAGAATRTGG

(p.Tyr2677Cys)

AAATCTGGTGACTATACAGTCA′]

3310
NM_000487.5(ARSA):
410
ARSA
[′GAGGGGGTTTGTGCCTGATAACGTARTAA

c.*96A > G

CACCAGTGGAGACTTGCAGATG′]

3311
NM_000487.5(ARSA): c.1055A > G
410
ARSA
[′GCCCTGGCTGGGGCCCCACTGCCCARTGTC

(p.Asn352Ser)

ACCTTGGATGGCTTTGACCTC′]

3312
NM_000218.2(KCNQ1): c.418A > G
3784
KCNQ1
[′CATCGTCCTGGTCTGCCTCATCTTCRGCGT

(p.Ser140Gly)

GCTGTCCACCATCGAGCAGTA′]

3313
NM_172250.2(MMAA): c.620A > G
166785
MMAA
[′GAGTTATCAAGAGATATGAATGCATRCAT

(p.Tyr207Cys)

CAGGCCATCTCCTACTAGAGGA′]

3314
NM_000187.3(HGD): c.1112A > G
3081
HGD
[′AGTCTACACAGCACAATGACCCCCCRTGG

(p.His371Arg)

ACCTGATGCTGACTGCTTTGAG′]

3315
NM_000187.3(HGD): c.1102A > G
3081
HGD
[′AGGGGGAGGGAGTCTACACAGCACARTGA

(p.Met368Val)

CCCCCCATGGACCTGATGCTGA′]

3316
NM_138477.2(CDAN1):
146059
CDAN1
[′CTGAGCTTGAAGATCCAGGAGCTCARTGG

c.1796A > G (p.Asn599Ser)

TCTTGCCCTGCCCCAGCATGAG′]

3317
NM_001079802.1(FKTN):
2218
FKTN
[′GTAAAACTTGATGTTTTTTTCTTCTRTGAA

c.1112A > G (p.Tyr371Cys)

GAAACTGATCACATGTGGAAT′]

3318
NM_013382.5(POMT2):
29954
POMT2
[′GCTTGAGAAGAGCATGGCTGGGAAGYAGT

c.1997A > G (p.Tyr666Cys)

GGTGGAAGTAGAGGACCCGGCC′]

3319
NM_000529.2(MC2R): c.761A > G
4158
MC2R
[′CCAAGTAACCCCTACTGCGCCTGCTRCATG

(p.Tyr254Cys)

TCTCTCTTCCAGGTGAACGGC′]

3320
NM_000383.3(AIRE): c.247A > G
326
AIRE
[′CCTGGACTTCTGGAGGGTGCTGTTCRAGGA

(p.Lys83Glu)

CTACAACCTGGAGCGCTATGG′]

3321
NM_020436.3(SALL4):
57167
SALL4
[′TCGTCTGCTAGCGCTCTTCAGATCCRCGAG

c.2663A > G (p.His888Arg)

CGGACTCACACTGGAGAGAAG′]

3322
NM_203288.1(RP9): c.509A > G
6100
RP9
[′CAGTTACTGGAGGATTCTACCTCAGRTGAA

(p.Asp170Gly)

GATAGGAGCAGCTCCAGTTCC′]

3323
NM_000348.3(SRD5A2):
6716
SRD5A2
[′TTCCTTGGGCTGCGAGCTTTTCACCRCCAT

c.692A > G (p.His231Arg)

AGGTAAATTTTTCAATAAAAG′]

3324
NM_006445.3(PRPF8):
10594
PRPF8
[′CCCAAAGAGTTCTACCACGAGGTGCVCAG

c.6926A > G (p.His2309Arg)

GCCCTCTCACTTCCTCAACTTT′]

3325
NM_018319.3(TDP1): c.1478A > G
55775
TDP1
[′TCTGGCCGCAGCAATGCCATGCCACRTATT

(p.His493Arg)

AAGACATATATGAGGCCTTCT′]

3326
NM_144773.2(PROKR2):
128674
PROKR2
[′AGCCAGGAGAAGATCTTCTGTGGCCRGAT

c.629A > G (p.Gln210Arg)

CTGGCCTGTGGATCAGCAGCTC′]

3327
NM_001604.5(PAX6):
5080
PAX6
[′ACCACAGGTTTGCCTCTCTCCTCACRGCCC

c.1075 − 2A > G

CCAGTCCCCAGCCAGACCTCC′]

3328
NM_000280.4(PAX6): c.1171A > G
5080
PAX6
[′CAGTCAGCCAATGGGCACCTCGGGCRCCA

(p.Thr391Ala)

CTTCAACAGGTGAGCCACTGCT′]

3329
NM_024426.4(WT1): c.1391A > G
7490
WT1
[′TGTCAGCGAAAGTTCTCCCGGTCCGRCCAC

(p.Asp464Gly)

CTGAAGACCCACACCAGGACT′]

3330
NM_024426.4(WT1): c.1021A > G
7490
WT1
[′TTGCAGCCACAGCACAGGGTACGAGRGCG

(p.Ser341Gly)

ATAACCACACAACGCCCATCCT′]

3331
NM_005957.4(MTHFR): c.971A > G
4524
MTHFR
[′CCAGGCCTCCACTTCTACACCCTCARCCGC

(p.Asn324Ser)

GAGATGGCTACCACAGAGGTG′]

3332
NM_001127328.2(ACADM):
34
ACADM
[′TAACTCATTCTAGCTAGTTCAACTTYCATT

c.997A > G (p.Lys333Glu)

GCCATTTCAGCCAGCATAAAT′]

3333
NM_001127328.2(ACADM):
34
ACADM
[′TATTAATGGTCAGAAGATGTGGATARCCA

c.589A > G (p.Thr197Ala)

ACGGAGGAAAAGCTAATTGGTA′]

3334
NM_000155.3(GALT): c.940A > G
2592
GALT
[′AGGATCAGAGGCTGGGGCCAACTGGRACC

(p.Asn314Asp)

ATTGGCAGCTGCACGCTCATTA′]

3335
NM_000155.3(GALT): c.563A > G
2592
GALT
[′TGTTCTAACCCCCACCCCCACTGCCRGGTA

(p.Gln188Arg)

AGGGTGTCAGGGGCTCCAGTG′]

3336
NM_000250.1(MPO): c.518A > G
4353
MPO
[′GTTGCACATCCCGGTGATGGTGCGGYATTT

(p.Tyr173Cys)

GTCCTGCTCCGGGCAAGTCAC′]

3337
NM_020247.4(ADCK3):
56997
ADCK3
[′TTGGATTTTGGGGCAACGCGGGAATRTGA

c.1541A > G (p.Tyr514Cys)

CAGATCCTTCACCGACCTCTAC′]

3338
NM_000229.1(LCAT): c.463A > G
3931
LCAT
[′CACACTGGTGCAGAACCTGGTCAACRATG

(p.Asn155Asp)

GCTACGTGCGGGACGAGACTGT′]

3339
NM_000403.3(GALE): c.101A > G
2582
GALE
[′GGCTACTTGCCTGTGGTCATCGATARCTTC

(p.Asn34Ser)

CATAATGCCTTCCGTGGTGAG′]

3340
NM_001008216.1(GALE):
2582
GALE
[′GGCGAGTCGGTGCAGAAGCCTCTGGRTTA

c.308A > G (p.Asp103Gly)

TTACAGAGTTAACCTGACCGGG′]

3341
NM_000403.3(GALE): c.770A > G
2582
GALE
[′AAGGGCCACATTGCAGCCTTAAGGARGCT

(p.Lys257Arg)

GAAAGAACAGTGTGGCTGCCGG′]

3342
NM_000527.4(LDLR): c.2483A > G
3949
LDLR
[′AGCATCAACTTTGACAACCCCGTCTRTCAG

(p.Tyr828Cys)

AAGACCACAGAGGATGAGGTC′]

3343
NM_024740.2(ALG9): c.860A > G
79796
ALG9
[′ATTGCACCACTCAACATTGTTTTGTRTAAT

(p.Tyr287Cys)

GTCTTTACTCCTCATGGACCT′]

3344
NM_000375.2(UROS): c.184A > G
7390
UROS
[′TGAAGATTACGGGGGACTCATTTTTRCCAG

(p.Thr62Ala)

CCCCAGAGCAGTGGAAGCAGC′]

3345
NM_000372.4(TYR): c.125A > G
7299
TYR
[′GAATGCTGTCCACCGTGGAGCGGGGRCAG

(p.Asp42Gly)

GAGTCCCTGTGGCCAGCTTTCA′]

3346
NM_000372.4(TYR): c.1A > G
7299
TYR
[′AGACCTTGTGAGGACTAGAGGAAGARTGC

(p.Met1Val)

TCCTGGCTGTTTTGTACTGCCT′]

3347
NM_000053.3(ATP7B):
540
ATP7B
[′GTCGCCATGGTGGGGGATGGGGTCADTGA

c.3809A > G (p.Asn1270Ser)

CTCCCCGGCCTTGGCCCAGGCA′]

3348
NM_000520.4(HEXA): c.1A > G
3073
HEXA
[′CTCCGAGAGGGGAGACCAGCGGGCCVTGA

(p.Met1Val)

CAAGCTCCAGGCTTTGGTTTTC′]

3349
NM_000520.4(HEXA): c.611A > G
3073
HEXA
[′AATAAATTGAACGTGTTCCACTGGCRTCTG

(p.His204Arg)

GTAGATGATCCTTCCTTCCCA′]

3350
NM_000356.3(TCOF1): c.149A > G
6949
TCOF1
[′CAGCCCGTAACCCTTCTGGACATCTRTACA

(p.Tyr50Cys)

CACTGGCAACAGTAAGTGGTG′]

3351
NM_000144.4(FXN):
2395
FXN
[′ATGCTTTTTTTCCACCTAATCCCCTRGAGT

c.38 − 2A > G

GGTGTCTTAACTGTCAAACTG′]

3352
NM_016335.4(PRODH):
5625
PRODH
[′GCCTAGCAGCTGTCCAAAGTACACCYGGT

c.1562A > G (p.Gln521Arg)

GGTCAGCAGGATGCAGGCCCAG′]

3353
NM_015474.3(SAMHD1):
25939
SAMHD1
[′TAATTCTAATGGAATTAAGCCTGTCRTGGA

c.760A > G (p.Met254Val)

ACAATATGGTCTCATCCCTGA′]

3354
NM_012464.4(TLL1): c.1885A > G
7092
TLL1
[′ACTTCTTACCAAACTTAACGGCACCRTAAC

(p.Ile629Val)

CACCCCTGGCTGGCCCAAGGA′]

3355
NM_000112.3(SLC26A2):
1836
SLC26A2
[′GGAAATGTATGCCATTGGCTTTTGTRATAT

c.1273A > G (p.Asn425Asp)

CATCCCTTCCTTCTTCCACTG′]

3356
NM_138691.2(TMC1): c.1960A > G
117531
TMC1
[′CCTGTCCACAATGCCTGTCTTGTACRTGAT

(p.Met654Val)

CGTGTCCCTCCCACCATCTTT′]

3357
NM_000173.6(GP1BA): c.763A > G
2811
GP1BA
[′GAAGCAAGGTGTGGACGTCAAGGCCRTGA

(p.Met255Val)

CCTCTAATGTGGCCAGTGTGCA′]

3358
NM_024996.5(GFM1): c.521A > G
85476
GFM1
[′AACGTTCCGTTTCTAACTTTTATTARCAAA

(p.Asn174Ser)

TTGGACCGAATGGGCTCCAAC′]

3359
NM_024301.4(FKRP): c.926A > G
79147
FKRP
[′GTGGGCGACACGCCCGCCTACCTCTRCGA

(p.Tyr309Cys)

GGAGCGCTGGACGCCCCCCTGC′]

3360
NM_024301.4(FKRP): c.1387A > G
79147
FKRP
[′TGCCGGCTTCGTGGCGCAGGCGCCTRACA

(p.Asn463Asp)

ACTACCGCCGCTTCCTGGAGCT′]

3361
NM_021020.3(LZTS1): c.355A > G
11178
LZTS1
[′TCCTTTTCCTCTACAGGGCTCCGAGRAGGG

(p.Lys119Glu)

TGCAGTGAGGCCCACAGCCTT′]

3362
NM_001005741.2(GBA):
2629
GBA
[′CCAGCCGACCACATGGTACAGGAGGBTCT

c.1226A > G (p.Asn409Ser)

AGGGTAAGGACAAAGGCAAAGA′]

3363
NM_000157.3(GBA): c.680A > G
2629
GBA
[′ACATCACCCACTTGGCTCAAGACCARTGG

(p.Asn227Ser)

AGCGGTGAATGGGAAGGGGTCA′]

3364
NM_001005741.2(GBA):
2629
GBA
[′AAATATGTTCATGGCATTGCTGTACRTTGG

c.1049A > G (p.His350Arg)

TACCTGGACTTTCTGGCTCCA′]

3365
NM_014239.3(EIF2B2):
8892
EIF2B2
[′GTGAATTTGTCCAAAGCAGGTATTGRGAC

c.638A > G (p.Glu213Gly)

AACTGTCATGACTGATGCTGCC′]

3366
NM_015915.4(ATL1): c.773A > G
51062
ATL1
[′CTACAGAACGTCAGAAAACACATCCRTTC

(p.His258Arg)

CTGTTTCACCAACATTTCCTGT′]

3367
NM_015915.4(ATL1): c.1222A > G
51062
ATL1
[′GAAGCTATTCCGAGGGGTGAAGAAGRTGG

(p.Met408Val)

GTGGGGAAGAATTTAGCCGGCG′]

3368
NM_022051.2(EGLN1):
54583
EGLN1
[′TTCTGGTCTGACCGTCGCAACCCTCRTGAA

c.1121A > G (p.His374Arg)

GTACAACCAGCATATGCTACA′]

3369
NM_015629.3(PRPF31):
26121
PRPF31
[′GTCACCGCCTCCACCACCCAGGGGTRTGTC

c.527 + 3A > G

CGCTTCGAGGGAGGCGCCGGG′]

3370
NM_001243133.1(NLRP3):
114548
NLRP3
[′CTGCAGATCCAGCCCAGCCAGCTGGRATT

c.1880A > G (p.Glu627Gly)

GTTCTACTGTTTGTACGAGATG′]

3371
NM_020919.3(ALS2):
57679
ALS2
[′CTTATTGACGTTACTTTTTGCTCCTRGACA

c.2980 − 2A > G

AAGTGGCTACGAGCTATAAGC′]

3372
NM_175073.2(APTX): c.602A > G
54840
APTX
[′GATAAATACCCAAAGGCCCGTTACCRTTG

(p.His201Arg)

GCTGGTCTTACCGTGGACCTCC′]

3373
NM_001002010.2(NT5C3A):
51251
NT5C3A
[′CATCCCAATGTCAAAGTTGTGTCCARTTTT

c.686A > G (p.Asn229Ser)

ATGGATTTTGATGAAACTGTA′]

3374
NM_020451.2(SEPN1): c.1A > G
57190
SEPN1
[′CCGGCAGCCGCCGCCAGCCGCAGCCRTGG

(p.Met1Val)

GCCGGGCCCGGCCGGGCCAACG′]

3375
NM_032667.6(BSCL2): c.263A > G
−1
—
[′TCACTCTGCTCCTTCCCTGTTGCCARTGTCT

(p.Asn88Ser)

CGCTGACTAAGGGTGGACGT′]

3376
NM_153638.2(PANK2): c.700A > G
80025
PANK2
[′GGTATATTTTGAACCCAAAGACATCRCTGC

(p.Thr234Ala)

TGAAGAAGAAGAGGAAGAAGT′]

3377
NM_025243.3(SLC19A3):
80704
SLC19A3
[′TGCCTTGGTGATTCAGACCATCATGRCTGT

c.1264A > G (p.Thr422Ala)

GATTGTAGTAGATCAGAGAGG′]

3378
NM_025243.3(SLC19A3):
80704
SLC19A3
[′TATCCCATATTTATCTGGACCAGATRAAAA

c.130A > G (p.Lys44Glu)

CCTGACCAGTGCAGAGGTAAG′]

3379
NM_031885.3(BBS2): c.209A > G
583
BBS2
[′CAGACAGCTGACTGCCTGGTTAATGYTGA

(p.Asn70Ser)

GAAGAGAAACATCAGATTCCAG′]

3380
NM_032383.4(HPS3):
−1
—
[′TTTATGAGAAATTCTTTTATGTTTTRGATA

c.2482 − 2A > G

AATGCCTGTAGTCATTATGGC′]

3381
NM_021830.4(C10orf2):
56652
C10orf2
[′TGACCTTCGGTCCTGGGAAGCCGCCVAGTT

c.955A > G (p.Lys319Glu)

GTTTGCACGAAAACTGAACCC′]

3382
NM_021830.4(C10orf2):
56652
C10orf2
[′ACAATGCAACATGCAGTCTACGTCTRTGAC

c.1523A > G (p.Tyr508Cys)

ATTTGTCATGTGATCATCGAC′]

3383
NM_006492.2(ALX3): c.608A > G
257
ALX3
[′ACCTGCCCCCAGGTCTGGTTCCAGARCCGC

(p.Asn203Ser)

AGAGCCAAGTGGCGGAAGCGC′]

3384
NM_174916.2(UBR1): c.407A > G
197131
UBR1
[′TTCCAGGACAGTGTTCATAAAAATCRTCGT

(p.His136Arg)

TACAAGGTAAGAAAATATAAC′]

3385
NM_015166.3(MLC1): c.422A > G
23209
MLC1
[′CTAGTCCTGAACCCATCAGCAATAARCGT

(p.Asn141Ser)

GAGTTCACACGAGCTTCGCGCA′]

3386
NM_013391.3(DMGDH):
29958
DMGDH
[′CCTGGAATAAACTTGAAGAAAATACRTTA

c.326A > G (p.His109Arg)

TGATAGCATCAAACTTTATGAG′]

3387
NM_014795.3(ZEB2): c.3356A > G
9839
ZEB2
[′GCTTACTTGCAGAGCATTACCCCTCRGGGG

(p.Gln1119Arg)

TACTCTGACTCGGAGGAGAGG′]

3388
NM_000441.1(SLC26A4):
5172
SLC26A4
[′GTTGTCATCCAGTCTCTTCCTTAGGRATTC

c.1151A > G (p.Glu384Gly)

ATTGCCTTTGGGATCAGCAAC′]

3389
NM_000441.1(SLC26A4):
5172
SLC26A4
[′TTATGCTATTGCAGTGTCAGTAGGARAAGT

c.1105A > G (p.Lys369Glu)

ATATGCCACCAAGTATGATTA′]

3390
NM_000441.1(SLC26A4):
5172
SLC26A4
[′AAGGACACATTCTTTTTGACGGTCCRTGAT

c.2168A > G (p.His723Arg)

GCTATACTCTATCTACAGAAC′]

3391
NM_000441.1(SLC26A4):
5172
SLC26A4
[′TTTTTAACATCTTTTGTTTTATTTCRGACGA

c.919 − 2A > G

TAATTGCTACTGCCATTTCA′]

3392
NM_000197.1(HSD17B3):
3293
HSD17B3
[′GACCCCATATGCTGTCTCGACTGCARTGAC

c.703A > G (p.Met235Val)

AAAGTATCTAAATACAAATGT′]

3393
NM_000197.1(HSD17B3):
3293
HSD17B3
[′TTGTTTTGCTTCTTTCTGCCAGTCARCAATG

c.389A > G (p.Asn130Ser)

TCGGAATGCTTCCAAACCTT′]

3394
NM_022458.3(LMBR1):
64327
LMBR1
[′GTTTTGATCTTAGTGTTTATTACAGRAAAT

c.423 + 5252A > G

GAAGCCATATCTCACTAACTA′]

3395
NM_020366.3(RPGRIP1):
57096
RPGRIP1
[′CTAAATAAACATTTTCCTTATCAGGRTTCA

c.3341A > G (p.Asp1114Gly)

GAGAAGATGTGCATTGAAATT′]

3396
NM_021625.4(TRPV4): c.998A > G
59341
TRPV4
[′CTGCATGCGCTGGTGGCCATTGCTGRCAAC

(p.Asp333Gly)

ACCCGTGAGAACACCAAGTTT′]

3397
NM_004897.4(MINPP1):
9562
MINPP1
[′TTAAAAAAAGTTGCAGCTACTTTGCRAGTG

c.809A > G (p.Gln270Arg)

CCAGTAAATGATTTAAATGCA′]

3398
NM_020638.2(FGF23): c.211A > G
8074
FGF23
[′TGGCGCACCCCATCAGACCATCTACRGTG

(p.Ser71Gly)

AGTAGGGCTTCAGGCTGGGAAG′]

3399
NM_015071.4(ARHGAP26):
23092
ARHGAP26
[′GGGCTGTATCGAATTGTGGGTGTCAVCTCC

c.1250A > G (p.Asn417Ser)

AGAGTGCAGAAGTTGCTGAGT′]

3400
NM_021615.4(CHST6): c.521A > G
4166
CHST6
[′CGCTCCTACAGCCACGTGGTGCTCARGGA

(p.Lys174Arg)

GGTGCGCTTCTTCAACCTGCAG′]

3401
NM_021615.4(CHST6): c.329A > G
4166
CHST6
[′TGCGACATGGACGTGTTTGATGCCTRTCTG

(p.Tyr110Cys)

CCTTGGCGCCGCAACCTGTCC′]

3402
NM_015560.2(OPA1): c.1745A > G
4976
OPA1
[′CTTGAAACTGAATGGAAGAATAACTRTCC

(p.Tyr582Cys)

TCGCCTGCGGGAACTTGACCGG′]

3403
NM_000368.4(TSC1): c.1760A > G
7248
TSC1
[′AGTATCTTCACTCCCAGTCCTTGTARAATT

(p.Lys587Arg)

CCACCTCCGACGAGAGTGGGC′]

3404
NM_020661.2(AICDA): c.415A > G
57379
AICDA
[′CCGCGCCGGGGTGCAAATAGCCATCRTGA

(p.Met139Val)

CCTTCAAAGGTGCGAAAGGGCC′]

3405
NM_020533.2(MCOLN1):
57192
MCOLN1
[′ACAGGCCCTCCCCTTCTCTGCCCACRGTAC

c.406 − 2A > G

CTGGCGTTGCCTGACGTGTCA′]

3406
NM_021102.3(SPINT2):
10653
SPINT2
[′AGGAACTCCTGCAATAACTTCATCTRTGGA

c.488A > G (p.Tyr163Cys)

GGCTGCCGGGGCAATAAGAAC′]

3407-
NM_006610.3(MASP2): c.359A > G
10747
MASP2
[′GGGAGGGCTGGGGTTTCTCAGGGTCRGGG

3410
(p.Asp120Gly)

GGTCCCCAAGGAGTAGCCAGGG′,

′AGGGGCCAGGCTTGGCCAGGAGGGASATC

AGGCCTGGGTCTTGCCTTCACT′,

′GGGCAGGAGAGCACAGACACGGAGCRGGC

CCCTGGCAAGGACACTTTCTAC′,

′AGCCTGGACATTACCTTCCGCTCCGRCTAC

TCCAACGAGAAGCYGTTCACG′]

3411
NM_018965.3(TREM2): c.401A > G
54209
TREM2
[′GCTCTGCCTCCCATAGACCCCCTGGRTCAC

(p.Asp134Gly)

CGGGATGCTGGAGATCTCTGG′]

3412
NM_007375.3(TARDBP):
23435
TARDBP
[′AGCACTACAGAGCAGTTGGGGTATGRTGG

c.1009A > G (p.Met337Val)

GCATGTTAGCCAGCCAGCAGAA′]

3413
NM_007375.3(TARDBP):
23435
TARDBP
[′GTAATGTCACAGCGACATATGATAGRTGG

c.506A > G (p.Asp169Gly)

ACGATGGTGTGACTGCAAACTT′]

3414
NM_007375.3(TARDBP):
23435
TARDBP
[′GGTATGATGGGCATGTTAGCCAGCCRGCA

c.1028A > G (p.Gln343Arg)

GAACCAGTCAGGCCCATCGGGT′]

3415
NM_007375.3(TARDBP):
23435
TARDBP
[′CGTTCATATATCCAATGCCGAACCTRAGCA

c.787A > G (p.Lys263Glu)

CAATAGCAATAGACAGTTAGA′]

3416
NM_015247.2(CYLD): c.2240A > G
1540
CYLD
[′ATCAACAGTAACCTGAAATTTGCAGRGGT

(p.Glu747Gly)

TAGTGATACTCACCTGTGGTAT′]

3417
NM_001128425.1(MUTYH):
4595
MUTYH
[′AATCAACTCTGGGCTGGCCTGGGCTRCTAT

c.536A > G (p.Tyr179Cys)

TCTCGTGGCCGGCGGCTGCAG′]

3418
NM_001128425.1(MUTYH):
4595
MUTYH
[′TCCGTGACCTGGGAGCCCTCAGAGCRGCTT

c.1241A > G (p.Gln414Arg)

CAGCGCAAGGCCCTGCTGCAG′]

3419
NM_170784.2(MKKS): c.110A > G
8195
MKKS
[′TTGAAAAGAATTGTAACATCATGCTRTGGC

(p.Tyr37Cys)

CCCTCAGGTAGGCTGAAGCAG′]

3420
NM_170784.2(MKKS): c.169A > G
8195
MKKS
[′TGGCTTTGGAGGTTACGTGTGTACARCCTC

(p.Thr57Ala)

ACAGTCCTCAGCTCTGCTCAG′]

3421
NM_004795.3(KL): c.578A > G
9365
KL
[′GTGCAGCCCGTGGTCACCCTGTACCRCTGG

(p.His193Arg)

GACCTGCCCCAGCGCCTGCAG′]

3422
NM_014625.3(NPHS2): c.479A > G
7827
NPHS2
[′CTTTTCTTTTTTTTGCCCTGCCTGGRTACCT

(p.Asp160Gly)

ACCACAAGGTTGACCTTCGT′]

3423
NM_015713.4(RRM2B):
50484
RRM2B
[′CACCTCCTGACTAAAGCGCTCCACCBAAG

c.322 − 2A > G

AAGATAAGGAAAATAGATATAT′]

3424
NM_006343.2(MERTK):
10461
MERTK
[′GAAGTATCTTTGTTTTCATTCACCCRGGAA

c.1605 − 2A > G

TGCATTCACAGAGGAGGATTC′]

3425
NM_014585.5(SLC40A1):
30061
SLC40A1
[′GCTACTGCAATCACAATCCAAAGGGRTTG

c.470A > G (p.Asp157Gly)

GATTGTTGTTGTTGCAGGAGAA′]

3426
NM_004924.4(ACTN4): c.763A > G
81
ACTN4
[′CGTGAACACGGCCCGGCCCGACGAGRAGG

(p.Lys255Glu)

CCATAATGACCTATGTGTCCAG′]

3427
NM_012193.3(FZD4): c.1024A > G
−1
—
[′CAAATGGGGTCATGAAGCCATTGAARTGC

(p.Met342Val)

ACAGCTCTTATTTCCACATTGC′]

3428
NM_012193.3(FZD4): c.766A > G
−1
—
[′GTTTTCCTACCCTGAGCGCCCCATCRTATT

(p.Ile256Val)

TCTCAGTATGTGCTATAATAT′]

NM_004239.3(TRIP11):
9321
TRIP11

c.202 − 2A > G

3429
NM_004239.3(TRIP11):
9321
TRIP11
[′AGTGTTTTTTTCCAGAGAAAGCTGAYTGTT

c.2102A > G (p.Asn701Ser)

ACCAGCAAGACATTCTTCTAA′]

3430
NM_012434.4(SLC17A5):
26503
SLC17A5
[′CAGGGTGTTACATTTCCAGCCATGCRTGCC

c.548A > G (p.His183Arg)

ATGTGGTCTTCTTGGGCTCCC′]

3431
NM_001099274.1(TINF2):
26277
TINF2
[′ATGGGCCTCCACTAGGGGAGGCCATDAGG

c.838A > G (p.Lys280Glu)

AGCGCCCCACAGTCATGCTGTT′]

3432
NM_012415.3(RAD54B):
25788
RAD54B
[′AGAGTTGAACAAAAGGCAGGGGTGAYTGC

Gc.1778A > (p.Asn593Ser)

ACAGTTTTTTAAGAGCTCCTAT′]

3433
NM_014946.3(SPAST):
6683
SPAST
[′TAAGTGCCTGACTTTTATGTTTTACRGAAC

c.1688 − 2A > G

TAAAACCAGAACAGGTGAAGA′]

3434
NM_014946.3(SPAST):
6683
SPAST
[′AGTCTTATACTTGTATTTCCTCTAGRTGAA

c.1322A > G (p.Asp441Gly)

GTTGATAGCCTTTTGTGTGAA′]

3435
NM_014946.3(SPAST):
6683
SPAST
[′TGCAAGTTTAACTTCAAAATACGTGRGTGC

c.1245 + 4A > G

TCTGTTTCCAATATTGTCGTA′]

3436
NM_014946.3(SPAST):
6683
SPAST
[′CTGTTACTCTTTGGTCCACCTGGGARTGGG

c.1157A > G (p.Asn386Ser)

AAGACAATGCTGGTAAGGGTT′]

3437
NM_014946.3(SPAST):
6683
SPAST
[′AGAATCGAATGCAACCTTCTTTAATRTAAG

c.1216A > G (p.Ile406Val)

TGCTGCAAGTTTAACTTCAAA′]

3438
NM_182643.2(DLC1): c.2875A > G
10395
DLC1
[′ACACCTGGATGTGGACAACGACCGARCCA

(p.Thr959Ala)

CACCCAGCGACCTGGACAGCAC′]

3439
NM_194456.1(KRIT1): c.410A > G
889
KRIT1
[′TGCCCAATTTTTTACTGCTTACAAGRTATT

(p.Asp137Gly)

ATGCGAGTCTGTAGTGAATCC′]

3440
NM_005094.3(SLC27A4):
10999
SLC27A4
[′CCAGGAAACATCGTGGGAATCGGCCRGTG

c.899A > G (p.Gln300Arg)

CCTGCTGCATGGCATGACGGTG′]

3441
NM_004211.3(SLC6A5):
9152
SLC6A5
[′GGAGGCCTGATCACTCTCTCTTCTTRCAAC

c.1472A > G (p.Tyr491Cys)

AAATTCCACAACAACTGCTAC′]

3442
NM_004211.3(SLC6A5):
9152
SLC6A5
[′GACACTCTAATTGTCACCTGCACCARCAGT

c.1526A > G (p.Asn509Ser)

GCCACAAGCATCTTTGCCGGC′]

3443
NM_014270.4(SLC7A9):
11136
SLC7A9
[′GCGTTTTACAATGGACTCTGGGCCTRTGAT

c.695A > G (p.Tyr232Cys)

GGATGGTGAGGTGTCCTGAGA′]

3444
NM_139025.4(ADAMTS13):
11093
ADAMTS13
[′GAGCCTGTGTGTGTCGGGCAGCTGCRGGG

c.1582A > G (p.Arg528Gly)

TAGGCGTGTGTGGACATTGGCG′]

3445
NM_002894.2(RBBP8):
5932
RBBP8
[′TGTATTTGGAGCTACCTCTAGTATCRAAAG

c.1009A > G (p.Lys337Glu)

TGGTTTAGATTTGAATACAAG′]

3446
NM_005682.6(ADGRG1):
9289
ADGRG1
[′TCCTTCCCTGACCCCAGGGGCCTCTRCCAC

Gc.263A > (p.Tyr88Cys)

TTCTGCCTCTACTGGAACCGA′]

3447
NM_006502.2(POLH): c.1603A > G
5429
POLH
[′AGGAACTGAGCCCTTCTTTAAGCAGRAAA

(p.Lys535Glu)

GTCTGCTTCTAAAGCAGAAACA′]

3448
NM_000334.4(SCN4A):
6329
SCN4A
[′CATCTCCTTCCTCATCGTGGTCAACRTGTA

c.4774A > G (p.Met1592Val)

CATCGCCATCATCCTGGAGAA′]

3449
NM_000334.4(SCN4A):
6329
SCN4A
[′CGCCCTCCTAGGCGCCATCCCCTCCRTCAT

c.3478A > G (p.Ile1160Val)

GAATGTGCTGCTTGTCTGCCT′]

3450
NM_000334.4(SCN4A): c.421A > G
6329
SCN4A
[′GTTCAGCATGTTCATCATGATCACCRTCTT

(p.Ile141 Val)

GACCAACTGCGTATTCATGAC′]

3451
NM_003907.2(EIF2B5):
8893
EIF2B5
[′CCTGACTGCCACAGGTGTACAGGAARCAT

c.271A > G (p.Thr91Ala)

TTGTCTTTTGTTGCTGGAAAGC′]

3452
NM_001128227.2(GNE):
10020
GNE
[′CAGTGCAGAGCAGCACCTGATATCCRTGT

c.604A > G (p.Met202Val)

GTGAGGACCATGATCGCATCCT′]

3453
NM_001029.3(RPS26): c.1A > G
6231
RPS26
[′CCTCTCTCCGGTCCGTGCCTCCAAGDTGGT

(p.Met1Val)

GAGTCTTCTTGCGTGGTGAGG′]

3454
NM_012082.3(ZFPM2):
−1
—
[′TCAAACTAAGAAGCTCTCCACCTCCRGTAA

c.1969A > G (p.Ser657Gly)

CAATGATGACAAAATTAATGG′]

3455
NM_012082.3(ZFPM2): c.89A > G
23414
ZFPM2
[′GATGAGGAAGAAGAATGTCCATCAGRGGA

(p.Glu30Gly)

AACAGACATCATCTCCAAAGGA′]

3456
NM_012082.3(ZFPM2):
−1
—
[′AAAGTGTTTATCTCAGTCTGAGCGGRCGAC

c.2527A > G (p.Thr843Ala)

CACGTCTCCCAAAAGGCTGCT′]

3457
NM_194248.2(OTOF):
9381
OTOF
[′TCTGGCTCCCCCTTCTCCTGCCTGCRGGTC

c.766 − 2A > G

AGCATCACGGTGATCGAGGCC′]

3458
NM_003705.4(SLC25A12): c.1769
8604
SLC25A12
[′GCTCGAGTGTTTCGATCCTCTCCCCRGTTT

A > G (p.Gln590Arg)

GGTGTTACCTTGGTCACTTAT′]

3459
NM_004621.5(TRPC6): c.428A > G
7225
TRPC6
[′AATGCCCTACAGTTGGCAGTGGCCARTGA

(p.Asn143Ser)

GCATCTGGAAATTACAGAACTT′]

3460
NM_152384.2(BBS5):
129880
BBS5
[′TTTGGAATTTATCCAGTGATCAGGTRTTGT

c.522 + 3A > G

GCAAAGAGCTAGTGAACCTTT′]

3461
NM_152384.2(BBS5): c.547A > G
129880
BBS5
[′GGGCAATTTAGGAACCTTTTTTATTRCCAA

(p.Thr183Ala)

TGTGAGAATTGTGTGGCATGC′]

3462
NM_001257342.1(BCS1L): c.232A
617
BCS1L
[′CCACAGTACCCGTACTCAGCACCTCRGTGT

> G (p.Ser78Gly)

CGAGACTTCGTACCTTCAGCA′]

3463
NM_004328.4(BCS1L): c.148A > G
617
BCS1L
[′GGCATTCCGGCGCCATTACATGATCRCACT

(p.Thr50Ala)

GGAAGTCCCTGCTCGAGACAG′]

3464
NM_003839.3(TNFRSF11A): c.508
8792
TNFRSF11
[′TGCCTTTTCCTCCACGGACAAATGCRGACC

A > G (p.Arg170Gly)

A
CTGGACCAAGTAAGTAACAAC′]

3465
NM_030761.4(WNT4): c.647A > G
54361
WNT4
[′TGCCACGGGGTGTCAGGCTCCTGTGRGGT

(p.Glu216Gly)

AAAGACGTGCTGGCGAGCCGTG′]

3466
NM_022817.2(PER2): c.1984A > G
8864
PER2
[′GCTGGCACTGCCGGGCAAGGCAGAGRGTG

(p.Ser662Gly)

TGGCGTCGCTCACCAGCCAGTG′]

3467
NM_002977.3(SCN9A):
−1
—
[′TAGGGCACGACCAATCAAATACACARGAA

c.1964A > G (p.Lys655Arg)

AAGGCGTTGTAGTTCCTATCTC′]

3468
NM_002977.3(SCN9A): c.184A > G
6335
SCN9A
[′GGAAGCTGGCAAACAGCTGCCCTTCRTCT

(p.Ile62Val)

ATGGGGACATTCCTCCCGGCAT′]

3469
NM_002977.3(SCN9A): c.29A > G
6335
SCN9A
[′GCAATGTTGCCTCCCCCAGGACCTCRGAGC

(p.Gln10Arg)

TTTGTCCATTTCACAAAACAG′]

3470
NM_001457.3(FLNB): c.604A > G
2317
FLNB
[′GCCTGTGGATAATGCACGAGAAGCCRTGC

(p.Met202Val)

AGCAGGCAGATGACTGGCTGGG′]

3471
NM_003060.3(SLC22A5):
6584
SLC22A5
[′GTAGGCATGGGCCAGATCTCCAACTRTGT

c.632A > G (p.Tyr211Cys)

GGCAGCATTTGTCCTGGGTATG′]

3472
NM_000369.2(TSHR): c.1856A > G
7253
TSHR
[′CCGCAGTACAACCCAGGGGACAAAGRTAC

(p.Asp619Gly)

CAAAATTGCCAAGAGGATGGCT′]

3473
NM_000369.2(TSHR): c.548A > G
7253
TSHR
[′TCTCTTCTCTCTGTTGGTTGTAGGARGCTG

(p.Lys183Arg)

TACAACAATGGCTTTACTTCA′]

3474
NM_001430.4(EPAS1):
2034
EPAS1
[′GGAGACACTGGCACCCTATATCCCCRTGG

c.1603A > G (p.Met535Val)

ACGGGGAAGACTTCCAGCTAAG′]

3475
NM_024009.2(GJB3): c.421A > G
2707
GJB3
[′GTTCAGCCTCATCTTCAAGCTCATCRTTGA

(p.Ile141Val)

GTTCCTCTTCCTCTACCTGCT′]

3476
NM_024009.2(GJB3): c.497A > G
2707
GJB3
[′ATGCCGCGCCTGGTGCAGTGTGCCADCGT

(p.Asn166Ser)

GGCCCCCTGCCCCAACATCGTG′]

3477
NM_001080463.1(DYNC2H1):
79659
DYNC2H1
[′TGTTTTTTTGCTTTTGTAGGTTGCCRTGGGT

c.11284A > G (p.Met3762Val)

CAAGGTCAAGCTGATTTAGC′]

3478
NM_001080463.1(DYNC2H1):
79659
DYNC2H1
[′CGCATGCCACCTGATGTAATTAGAGRTATT

c.9044A > G (p.Asp3015Gly)

CTTGAAGGAGTTTTAAGGTTG′]

3479
NM_001080463.1(DYNC2H1):
79659
DYNC2H1
[′GTTGACCCATCTCTGTTCCCTTCACRGGTA

c.4610A > G (p.Gln1537Arg)

AGGGGGCTTACGTGTAGAAGC′]

3480
NM_001080463.1(DYNC2H1):
79659
DYNC2H1
[′TGGTCCAAGTGGTGCTGGAAAATCARCGC

c.5959A > G (p.Thr1987Ala)

TTTGGAGAATGTTAAGGGCTGC′]

3481
NM_007035.3(KERA): c.740A > G
11081
KERA
[′GTGGCCTTTTTGAGACTAAATCACARCAAA

(p.Asn247Ser)

CTGTCAGATGAGGGTCTCCCA′]

3482
NM_003722.4(TP63): c.697A > G
8626
TP63
[′TATCCGCGCCATGCCTGTCTACAAARAAGC

(p.Lys233Glu)

TGAGCACGTCACGGAGGTGGT′]

3483
NM_003722.4(TP63): c.1052A > G
8626
TP63
[′CGGATCTGTGCTTGCCCAGGAAGAGRCAG

(p.Asp351Gly)

GAAGGCGGATGAAGATAGCATC′]

3484
NM_003722.4(TP63): c.1054A > G
8626
TP63
[′GATCTGTGCTTGCCCAGGAAGAGACRGGA

(p.Arg352Gly)

AGGCGGATGAAGATAGCATCAG′]

3485
NM_003742.2(ABCB11):
8647
ABCB11
[′AGAACAGTGGCTGCTTTTGGTGGTGRGAA

c.890A > G (p.Glu297Gly)

AAGAGAGGTTGAAAGGTTGGTT′]

3486
NM_006702.4(PNPLA6):
10908
PNPLA6
[′GGACCTCACGTACCCAGTCACCTCCRTGTT

c.3034A > G (p.Met1012Val)

CACTGGGTCTGCCTTTAACCG′]

3487
NM_006412.3(AGPAT2):
10555
AGPAT2
[′GTACACCACGGGGACGATGGGCACCYGCA

c.589 − 2A > G

GGCAGGGAGACGCACAGCTGAG′]

3488
NM_001084.4(PLOD3): c.668A > G
8985
PLOD3
[′AAGTCTCGGATCTTTCAGAACCTCARCGGG

(p.Asn223Ser)

GCTTTAGGTGAGGAGGAAGAC′]

3489
NM_138554.4(TLR4): c.896A > G
7099
TLR4
[′GCATACTTAGACTACTACCTCGATGRTATT

(p.Asp299Gly)

ATTGACTTATTTAATTGTTTG′]

3490
NM_001130978.1(DYSF):
8291
DYSF
[′GGGCCAGGTGCAGGAGACATCAAGGRTCC

c.3892A > G (p.Ile1298Val)

TGGATGAGGTGAGCTGGGCGTG′]

3491
NM_001130978.1(DYSF):
8291
DYSF
[′CTTTTTTGTCTTCTCTCTGGGGCAGRGGCT

c.5264A > G (p.Glu1755Gly)

GGCAGGATCCCAAACCCACAC′]

3492
NM_003494.3(DYSF):
8291
DYSF
[′CAGCTCTTAACCACTCCAGCCACTCRCTCT

c.3443 − 33A > G

GGCACCTCTGTTTTTTCCCTT′]

3493
NM_003494.3(DYSF):
8291
DYSF
[′AACTTGTCCCCTCCCTGTGTCTTCTRGCTGT

c.1285 − 2A > G

GCAGCAAGATCTTGGAGAAG′]

3494
NM_005450.4(NOG): c.665A > G
9241
NOG
[′CGCTGCGGCTGGATTCCCATCCAGTRCCCC

(p.Tyr222Cys)

ATCATTTCCGAGTGCAAGTGC′]

3495
NM_004629.1(FANCG):
2189
FANCG
[′GATACAATTTTTTTCTTTCTCTTTTRGGCCT

c.925 − 2A > G

TGAATGTCCCATGCAGTTCC′]

3496
NM_001701.3(BAAT): c.226A > G
570
BAAT
[′AGGGGATTATATGGGAGTCCACCCCRTGG

(p.Met76Val)

GTCTCTTCTGGTCTCTGAAACC′]

3497
NM_006892.3(DNMT3B):
1789
DNMT3B
[′TTTGGCTTTCCTGTGCACTACACAGRCGTG

c.2450A > G (p.Asp817Gly)

TCCAACATGGGCCGTGGTGCC′]

3498
NM_001360.2(DHCR7): c.839A > G
1717
DHCR7
[′GCTGCTTCTGTCTTGCAGGCCATCTRCGTG

(p.Tyr280Cys)

ATTGACTTCTTCTGGAACGAA′]

3499
NM_001360.2(DHCR7): c.1A > G
1717
DHCR7
[′AAGGTTCTCTTTCTTGCAGGGCCCARTGGC

(p.Met1Val)

TGCAAAATCGCAACCCAACAT′]

3500
NM_032119.3(ADGRV1):
84059
ADGRV1
[′TATCATCAGAGCATGTCACAGATCTRTGGA

c.18131A > G (p.Tyr6044Cys)

CTCATTCATGGTGACCTGTAA′]

3501
NM_004984.2(KIF5A): c.767A > G
3798
KIF5A
[′GTGCTGGACGAGGCAAAGAATATCARCAA

(p.Asn256Ser)

GTCACTGTCAGCTCTGGGCAAT′]

3502
NM_004984.2(KIF5A): c.827A > G
3798
KIF5A
[′GTCTCCTTCCTCCCCCAGAAAAGCTRTGTT

(p.Tyr276Cys)

CCATATCGTGACAGCAAAATG′]

3503
NM_007373.3(SHOC2): c.4A > G
8036
SHOC2
[′TTTTGTCCAGGCTTGAGTCACCATGRGTAG

(p.Ser2Gly)

TAGTTTAGGAAAAGAAAAAGA′]

3504
NM_016203.3(PRKAG2):
51422
PRKAG2
[′TACTCCTTGATCAAAAATAAAATCCRCAG

c.1148A > G (p.His383Arg)

ATTGCCCGTTATTGACCCTATC′]

3505
NM_016203.3(PRKAG2):
51422
PRKAG2
[′GTCCTGCTTTTCTCTTTGCAGGTCCRTCGG

c.1589A > G (p.His530Arg)

CTGGTGGTGGTAAATGAAGCA′]

3506
NM_003816.2(ADAM9):
8754
ADAM9
[′TTAAAATTTGTATACGTGTAATGCARCATT

c.411 − 8A > G

CAGAGGATTGCTGCATTTAGA′]

3507
NM_003002.3(SDHD): c.341A > G
6392
SDHD
[′GGCCTTGGACAAGTTGTTACTGACTRTGTT

(p.Tyr114Cys)

CATGGGGATGCCTTGCAGAAA′]

3508
NM_003002.3(SDHD): c.149A > G
6392
SDHD
[′GAATGGTGTGGAGTGCAGCACATACRCTT

(p.His50Arg)

GTCACCGAGCCACCATTGTATG′]

3509
NM_003002.3(SDHD): c.1A > G
6392
SDHD
[′ATGACCTTGAGCCCTCAGGAACGAGDTGG

(p.Met1Val)

CGGTTCTCTGGAGGCTGAGTGC′]

3510
NM_002485.4(NBN): c.511A > G
4683
NBN
[′TCAGTAAAATATTCTGGCTTTACAAYTGGA

(p.Ile171Val)

CGTCCACAAATGAGTGCACAT′]

3511
NM_170695.3(TGIF1): c.838A > G
7050
TGIF1
[′TTCCTGTACAGCTGGGCCAAACCCARCCCT

(p.Thr280Ala)

AGGGAGGCCACTGTCTCCTAA′]

3512
NM_002408.3(MGAT2): c.785A > G
4247
MGAT2
[′CTTATACTTTTCCTAGAAGAGGATCRCTAC

(p.His262Arg)

TTAGCCCCAGACTTTTACCAT′]

3513
NM_002408.3(MGAT2): c.952A > G
4247
MGAT2
[′GAAAACTTGGAAATCCACAGAGCACRATA

(p.Asn318Asp)

TGGGTCTAGCCTTGACCCGGAA′]

3514
NM_005422.2(TECTA):
7007
TECTA
[′CAGTCCAATGGCACGCATATCATGTRTAA

c.5609A > G (p.Tyr1870Cys)

AAACACACTCTGGATCGAAAGC′]

3515
NM_012233.2(RAB3GAP1):
22930
RAB3GAP1
[′GGTATTGTCTTTGCATGTATTTCCTRGGGA

c.649 − 2A > G

TGTCCTTTAACTCCATTGCCT′]

3516
NM_005025.4(SERPINI1):
5274
SERPINI1
[′GAGATTTTTCTTTCCAAAGCAATTCRCAAG

c.1013A > G (p.His338Arg)

TCCTTCCTAGAGGTTAATGAA′]

3517
NM_001040667.2(HSF4):
3299
HSF4
[′AGACGGTTTTCGGAAGGTGGTGAGCRTCG

c.256A > G (p.Ile86Val)

AGCAGGGCGGCCTGCTTAGGCC′]

3518
NM_001008211.1(OPTN):
10133
OPTN
[′GTTTACTGTTCTGATTTTCATGCTGRAAGA

c.1433A > G (p.Glu478Gly)

GCAGCGAGAGAGAAAATTCAT′]

3519
NM_000492.3(CFTR): c.2738A > G
1080
CFTR
[′GTGATTATCACCAGCACCAGTTCGTRTTAT

(p.Tyr913Cys)

GTGTTTTACATTTACGTGGGA′]

3520
NM_000492.3(CFTR):
1080
CFTR
[′CTCAATAAGTCCTGGCCAGAGGGTGRGAT

c.3717 + 4A > G

TTGAACACTGCTTGCTTTGTTA′]

3521
NM_000492.3(CFTR): c.1666A > G
1080
CFTR
[′ACTGAGTGGAGGTCAACGAGCAAGARTTT

(p.Ile556Val)

CTTTAGCAAGGTGAATAACTAA′]

3522
NM_000492.3(CFTR): c.326A > G
1080
CFTR
[′TTACTGGGAAGAATCATAGCTTCCTRTGAC

(p.Tyr109Cys)

CCGGATAACAAGGAGGAACGC′]

3523
NM_000492.3(CFTR):
1080
CFTR
[′TGGAATCTTTTTATATTTAGGGGTARGGAT

c.273 + 4A > G

CTCATTTGTACATTCATTATG′]

3524
NM_000492.3(CFTR): c.3254A > G
1080
CFTR
[′CTGTTCCACAAAGCTCTGAATTTACRTACT

(p.His1085Arg)

GCCAACTGGTTCTTGTACCTG′]

3525
NM_000492.3(CFTR): c.3700A > G
1080
CFTR
[′CATATTAGAGAACATTTCCTTCTCANTAAG

(p.Ile1234Val)

TCCTGGCCAGAGGGTGAGATT′]

3526
NM_000492.3(CFTR): c.650A > G
1080
CFTR
[′GCACTCCTCATGGGGCTAATCTGGGRGTTG

(p.Glu217Gly)

TTACAGGCGTCTGCCTTCTGT′]

3527
NM_001005360.2(DNM2):
1785
DNM2
[′CCTCCACCCTCAGGAGAAAGAGAAGRAGT

c.1684A > G (p.Lys562Glu)

ACATGCTGCCTCTGGACAACCT′]

3528
NM_001814.4(CTSC): c.857A > G
1075
CTSC
[′TCTCAGACCCCAATCCTAAGCCCTCRGGAG

(p.Gln286Arg)

GTTGTGTCTTGTAGCCAGTAT′]

3529
NM_001814.4(CTSC): c.1235A > G
1075
CTSC
[′AATCATGCTGTTCTGCTTGTGGGCTRTGGC

(p.Tyr412Cys)

ACTGACTCAGCCTCTGGGATG′]

3530
NM_001814.4(CTSC): c.1040A > G
1075
CTSC
[′CGTTATTACTCCTCTGAGTACCACTRTGTA

(p.Tyr347Cys)

GGAGGTTTCTATGGAGGCTGC′]

3531
NM_005144.4(HR):
55806
HR
[′TCCGACCCCTCCAACCTGCGGCCCTRGAGC

c.−218A > G

GCCCCCGCCGCCCCGGGGGAA′]

3532
NM_172107.2(KCNQ2): c.851A > G
3785
KCNQ2
[′ACCACCATTGGCTACGGGGACAAGTRCCC

(p.Tyr284Cys)

CCAGACCTGGAACGGCAGGCTC′]

3533
NM_001303.3(COX10):
1352
COX10
[′GCCCTGAGCTGGGGCCTCCGTGAAGDCTA

c.1007A > G (p.Asp336Gly)

CTCCCGGGGCGGCTACTGCATG′]

3534
NM_006214.3(PHYH):
5264
PHYH
[′AGAACGTTATTATCCAGAGTATACCYAAA

c.135 − 2A > G

GGAGAAAAAGAATCCCAAAATA′]

3535
NM_002284.3(KRT86): c.340A > G
−1
—
[′GGAGAAGGAGCAGATCAAGTCCCTCVACA

(p.Asn114Asp)

GCAGGTTCGCGGCCTTCATCGA′]

3536
NM_003865.2(HESX1): c.541A > G
8820
HESX1
[′TCTAATGGCGAAAAAAAATTTCAACRCAA

(p.Thr181Ala)

ATCTGCTGGAATAGATAGAAAA′]

3537
NM_000303.2(PMM2): c.563A > G
5373
PMM2
[′TTTGATGTCTTTCCTGATGGATGGGRCAAG

(p.Asp188Gly)

AGATACTGTCTGCGACATGTG′]

3538
NM_000288.3(PEX7):
5191
PEX7
[′TCTTTTGCTTTCTAAACACTTTTCARTGTTT

c.340 − 10A > G

TTAGGTGTATAGTGTTGATT′]

3539
NM_004044.6(ATIC): c.1277A > G
471
ATIC
[′CTCATCGTAGCCACCATTGCTGTCARGTAC

(p.Lys426Arg)

ACTCAGTCTAACTCTGTGTGC′]

3540
NM_000314.6(PTEN): c.368A > G
5728
PTEN
[′GATGACAATCATGTTGCAGCAATTCRCTGT

(p.His123Arg)

AAAGCTGGAAAGGGACGAACT′]

3541
NM_000314.6(PTEN): c.278A > G
5728
PTEN
[′GTTGCACAATATCCTTTTGAAGACCRTAAC

(p.His93Arg)

CCACCACAGCTAGAACTTATC′]

3542
NM_000314.6(PTEN): c.755A > G
5728
PTEN
[′CCTCAGCCGTTACCTGTGTGTGGTGRTATC

(p.Asp252Gly)

AAAGTAGAGTTCTTCCACAAA′]

3543
NM_018488.2(TBX4): c.1592A > G
9496
TBX4
[′TCCTTGTCCCGAGAATCTTCCTTACRGTAC

(p.Gln531Arg)

CATTCAGGAATGGGGACTGTG′]

3544
NM_000223.3(KRT12): c.403A > G
3859
KRT12
[′AGAAACTATGCAAAATCTTAATGATRGAT

(p.Arg135Gly)

TAGCTTCCTACCTGGATAAGGT′]

3545
NM_000503.5(EYA1): c.1639A > G
2138
EYA1
[′TGAGAGAATAATTCAAAGGTTTGGARGAA

(p.Arg547Gly)

AAGTGGTGTATGTTGTTATAGG′]

3546
NM_000261.1(MYOC): c.1010A > G
4653
MYOC
[′GTGTACTCGGGGAGCCTCTATTTCCRGGGC

(p.Gln337Arg)

GCTGAGTCCAGAACTGTCATA′]

3547
NM_000261.1(MYOC): c.1267A > G
4653
MYOC
[′ACAAACCTGGGAGACAAACATCCGTRAGC

(p.Lys423Glu)

AGTCAGTCGCCAATGCCTTCAT′]

3548
NM_000474.3(TWIST1):
7291
TWIST1
[′GACCCTCAAGCTGGCGGCCAGGTACRTCG

c.466A > G (p.Ile156Val)

ACTTCCTCTACCAGGTCCTCCA′]

3549
NM_001089.2(ABCA3):
21
ABCA3
[′ACAGATCACCGTCCTGCTGGGCCACRACG

c.1702A > G (p.Asn568Asp)

GTGCCGGGAAGACCACCACCCT′]

3550
NM_005055.4(RAPSN):
5913
RAPSN
[′ATTCCTCAGAGGCCATGTGGCCCCARCTGG

c.−210A > G

CAGCGACAGCTGCAGACGGGC′]

3551
NM_198217.2(ING1): c.515A > G
3621
ING1
[′AACGAACCCACGTACTGTCTGTGCARCCA

(p.Asn172Ser)

GGTCTCCTATGGGGAGATGATC′]

3552
NM_000430.3(PAFAH1B1):
5048
PAFAH1B1
[′GATTTTGAACGAACTCTTAAAGGACRTAC

c.446A > G (p.His149Arg)

AGACTCTGTACAGGACATTTCA′]

3553
NM_000579.3(CCR5):
−1
—
[′TACGGGGAGAGTGGAGAAAAAGGGGRCA

c.−301 + 246A > G

CAGGGTTAATGTGAAGTCCAGGA′]

3554
NM_000264.3(PTCH1):
−1
—
[′ACTTTACGACCTACACAGGAGTTTCRGTAA

c.2479A > G (p.Ser827Gly)

CGTGAAGTATGTCATGTTGGA′]

3555
NM_001184.3(ATR): c.2022A > G
545
ATR
[′TCTGCTGCTGCAATAAGATAAAAAAYCCA

(p.Gly674=)

CTAACACAACTAGCCCGGATTA′]

3556
NM_005982.3(SIX1): c.386A > G
6495
SIX1
[′ATCTGGGACGGCGAGGAGACCAGCTRCTG

(p.Tyr129Cys)

CTTCAAGGAGAAGTCGAGGGGT′]

3557
NM_006267.4(RANBP2):
5903
RANBP2
[′AGAAGACGCACACATAACTTTTGCTRTATT

Gc.1966A > (p.Ile656Val)

GGATGCAGTAAATGGAAATAT′]

3558
NM_001001557.2(GDF6):
392255
GDF6
[′CCGCCCAGCTGCTGCGTGCCCACCARATTG

c.1271A > G (p.Lys424Arg)

ACTCCCATCAGCATTCTATAC′]

3559
NM_000557.4(GDF5): c.517A > G
8200
GDF5
[′ACCCCCCATCACACCCCACGAGTACVTGCT

(p.Met173Val)

CTCGCTGTACAGGACGCTGTC′]

3560
NM_000392.4(ABCC2):
1244
ABCC2
[′CGAGAGAAGCTGACCATCATCCCCCRGGT

c.4145A > G (p.Gln1382Arg)

GAGCTCTAGAACTTACTCGGGC′]

3561
NM_000396.3(CTSK): c.990A > G
1513
CTSK
[′ACCTGGCCAGCTTCCCCAAGATGTGRCTCC

(p.Ter330Trp)

AGCCAGCCAAATCCATCCTGC′]

3562
NM_001127221.1(CACNA1A):
773
CACNA1A
[′AACGTCTTCAACATCCTCATCGTCTRCATG

c.4151A > G (p.Tyr1384Cys)

CTATTCATGTTCATCTTCGCC′]

3563
NM_000178.2(GSS): c.656A > G
2937
GSS
[′CAAGAGAAGGAAAGAAACATATTTGRCCA

(p.Asp219Gly)

GCGTGCCATAGAGAATGAGCTA′]

3564
NM_000901.4(NR3C2):
4306
NR3C2
[′ACGCTCAACCGCTTAGCAGGCAAACRGAT

c.2327A > G (p.Gln776Arg)

GATCCAAGTCGTGAAGTGGGCA′]

3565
NM_000901.4(NR3C2):
4306
NR3C2
[′ATCAGCGACCAGCTGCCCAAGGTGGRGTC

c.2915A > G (p.Glu972Gly)

GGGGAACGCCAAGCCGCTCTAC′]

3566
NM_004407.3(DMP1): c.1A > G
1758
DMP1
[′CCAGGTAGAGGTATCACACCCAACTRTGA

(p.Met1Val)

AGATCAGCATCCTGCTCATGTT′]

3567
NM_004999.3(MYO6): c.737A > G
4646
MYO6
[′CAAGGCAAAGAGGAAAGAAATTATCRTAT

(p.His246Arg)

CTTTTATAGGTTGTGTGCTGGT′]

3568
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CGCCAGCAACAAGTACGGCCTGGCCRCAG

c.175A > G (p.Thr59Ala)

AGGGCACACGGCATACGCTGAC′]

3569
NM_000163.4(GHR): c.594A > G
2690
GHR
[′TGGAGTATGAACTTCAATACAAAGARGTA

(p.Glu198=)

AATGAAACTAAATGGAAAATGG′]

3570
NM_000525.3(KCNJ11):
3767
KCNJ11
[′ATCATGCTTGGCTGCATCTTCATGARGACT

c.509A > G (p.Lys170Arg)

GCCCAAGCCCACCGCAGGGCT′]

3571
NM_000525.3(KCNJ11):
3767
KCNJ11
[′CTGGTGGCCCCGCTGATCATCTACCRTGTC

c.776A > G (p.His259Arg)

ATTGATGCCAACAGCCCACTC′]

3572
NM_000182.4(HADHA):
3030
HADHA
[′GAAAAAAACTGCAAATTAAATGAGAYACC

c.180 + 3A > G

TTTGAATTGGGAGAGTTAATTC′]

3573
NM_005263.3(GFI1): c.1145A > G
2672
GFI1
[′GGCAAGGCATTCAGCCAGAGCTCCARCCT

(p.Asn382Ser)

CATCACCCACAGCCGCAAACAC′]

3574
NM_005263.3(GFI1): c.1208A > G
2672
GFI1
[′CCCTTCGGCTGCGACCTCTGTGGGARGGGT

(p.Lys403Arg)

TTCCAGAGGAAGGTGGACCTC′]

3575
NM_001893.4(CSNK1D):
1453
CSNK1D
[′TGCCATCAAGCTTGAATGTGTCAAARCCA

c.130A > G (p.Thr44Ala)

AACACCCTCAGCTCCACATTGA′]

3576
NM_006204.3(PDE6C):
5146
PDE6C
[′AAACAGAAAGGACATTGCTCAGGAARTGC

c.1363A > G (p.Met455Val)

TCATGAACCAAACCAAAGCCAC′]

3577
NM_006204.3(PDE6C):
5146
PDE6C
[′TGAAACAACCCATCCTTATTTCAACRGAAA

c.1483 − 2A > G

GAGGACTTGCCAGACCCACGC′]

3578
NM_003476.4(CSRP3): c.206A > G
8048
CSRP3
[′TGCTATGGGCGCAGATATGGCCCCARAGG

(p.Lys69Arg)

GATCGGGTATGGACAAGGCGCT′]

3579
NM_005591.3(MRE11A):
4361
MRE11A
[′GTGAACTATCAAGATGGCAACCTCARCAT

c.350A > G (p.Asn117Ser)

TTCAATTCCAGTGTTTAGTATT′]

3580
NM_000107.2(DDB2): c.730A > G
1643
DDB2
[′TTGGAATCTCAGAATGCACAAAAAGRAAG

(p.Lys244Glu)

TGACGCATGTGGCCCTGAACCC′]

3581
NM_001204.6(BMPR2):
659
BMPR2
[′AAGGAGACAATCGAAGACTGTTGGGRCCA

c.1454A > G (p.Asp485Gly)

GGATGCAGAGGCTCGGCTTACT′]

3582
NM_000336.2(SCNN1B):
6338
SCNN1B
[′ACAGAGAAGGCACTTCCTTCGGCCARCCC

Gc.863A > (p.Asn288Ser)

TGGAACTGAATTCGGTGAGTTT′]

3583
NM_000447.2(PSEN2): c.715A > G
5664
PSEN2
[′CTACCTCATCATGATCAGTGCGCTCRTGGC

(p.Met239Val)

CCTAGTGTTCATCAAGTACCT′]

3584
NM_002181.3(IHH): c.284A > G
3549
IHH
[′CCAGACATCATCTTCAAGGACGAGGRGAA

(p.Glu95Gly)

CACAGGCGCCGACCGCCTCATG′]

3585
NM_000310.3(PPT1): c.236A > G
5538
PPT1
[′ACTTCTCTCTGGCTTCTTTTTTAGGRCGTGG

(p.Asp79Gly)

AGAACAGCTTCTTCTTGAAT′]

3586
NM_003051.3(SLC16A1):
6566
SLC16A1
[′GCGACCAATCGGGCCCAAGCCAACCRAGG

c.610A > G (p.Lys204Glu)

CAGGGAAAGATAAGTCTAAAGC′]

3587
NM_005587.2(MEF2A): c.788A > G
4205
MEF2A
[′TCTCCCCCTCCACCAGGTGGTGGTARTCTT

(p.Asn263Ser)

GGAATGAACAGTAGGAAACCA′]

3588
NM_000098.2(CPT2): c.638A > G
1376
CPT2
[′TACCTGGTCAATGCGTATCCCCTGGRTATG

(p.Asp213Gly)

TCCCAGTATTTTCGGCTTTTC′]

3589
NM_000098.2(CPT2): c.359A > G
1376
CPT2
[′TTTTTAGGACCCTGGTTTGATATGTRCCTA

(p.Tyr120Cys)

TCTGCTCGAGACTCCGTTGTT′]

3590
NM_001079668.2(NKX2-1):
7080
NKX2-1
[′TCGCCGGGCCCATGAAGCGGGAGACHGTA

c.464 − 2A > G

AGCGACAAACGCACAGCGTCGG′]

3591
NM_004387.3(NKX2-5):
1482
NKX2-5
[′AACTTCGTGAACTTCGGCGTCGGGGRCTTG

c.896A > G (p.Asp299Gly)

AATGCGGTTCAGAGCCCCGGG′]

3592
NM_004387.3(NKX2-5):
1482
NKX2-5
[′GCTGAAACTCACGTCCACGCAGGTCRAGA

c.547A > G (p.Lys183Glu)

TCTGGTTCCAGAACCGGCGCTA′]

3593
NM_178138.4(LHX3): c.332A > G
8022
LHX3
[′GTGCGCCGCGCCCAGGACTTCGTGTRCCAC

(p.Tyr111Cys)

CTGCACTGCTTTGCCTGCGTC′]

3594
NM_001698.2(AUH):
549
AUH
[′CTTGTACTTTTTTTCCCCTTTAACTRGGAAT

c.263 − 2A > G

TGTGGTGCTTGGAATAAACA′]

3595
NM_001698.2(AUH):
549
AUH
[′ACATATTTAATATTTTGTTTTTCTTRGACCA

c.943 − 2A > G

TTCCAACAAAAGACAGACTT′]

3596
NM_001876.3(CPT1A):
1374
CPT1A
[′ATGTGTGTTTCACGTAGGTGGTTTGRCAAG

c.1361A > G (p.Asp454Gly)

TCGTTCACGTTTGTTGTCTTC′]

3597
NM_001876.3(CPT1A):
1374
CPT1A
[′CGGCTGCTGAAGCCCCGGGAGATGGRGCA

c.1079A > G (p.Glu360Gly)

GCAGATGCAGAGGATCCTGGAC′]

3598
NM_001876.3(CPT1A):
1374
CPT1A
[′TCCATTGACAGCCTCCAGCTGGGCTRTGCG

c.1493A > G (p.Tyr498Cys)

GAGGATGGGCACTGCAAAGGC′]

3599
NM_000352.4(ABCC8):
6833
ABCC8
[′CACCCTGCGCTCACGCCTCTCCATCRTCCT

c.4270A > G (p.Ile1424Val)

GCAGGACCCCGTCCTCTTCAG′]

3600
NM_000352.4(ABCC8): c.215A > G
6833
ABCC8
[′ACATGGCTTCATTTCCCTGGGCACARCCTG

(p.Asn72Ser)

CGGTGGATCCTGACCTTCATG′]

3601
NM_002180.2(IGHMBP2):
3508
IGHMBP2
[′TCTCAGAAAGAACTTGCCATCATCCRTGGA

c.638A > G (p.His213Arg)

CCTCCTGGCACTGGGAAAACC′]

3602
NM_033163.3(FGF8): c.298A > G
2253
FGF8
[′GAAGCACGTGCAGGTCCTGGCCAACRAGC

(p.Lys100Glu)

GCATCAACGCCATGGCAGAGGA′]

3603
NM_006180.4(NTRK2):
4915
NTRK2
[′TCCCGGGACGTGTACAGCACTGACTRCTAC

c.2165A > G (p.Tyr722Cys)

AGGGTGAGTAGCTGTGCAGAT′]

3604
NM_033028.4(BBS4):
585
BBS4
[′TCAGAAGCATTTTTCTCCCTCTTTCRGGCT

c.157 − 2A > G

GTTATCAAAGAACAGCTTCAA′]

3605
NM_000409.3(GUCA1A):
2978
GUCA1A
[′AAGCTCCGCTGGTACTTCAAGCTCTRTGAT

c.296A > G (p.Tyr99Cys)

GTAGATGGCAACGGCTGCATT′]

3606
NM_000344.3(SMN1): c.815A > G
6606
SMN1
[′TTAATTTCATGGTACATGAGTGGCTRTCAT

(p.Tyr272Cys)

ACTGGCTATTATATGGTAAGT′]

3607
NM_000344.3(SMN1): c.784A > G
6606
SMN1
[′TCTTGATGATGCTGATGCTTTGGGARGTAT

(p.Ser262Gly)

GTTAATTTCATGGTACATGAG′]

3608
NM_000095.2(COMP): c.1358A > G
1311
COMP
[′CGGGACAACTGTCCCACGGTGCCTARCAG

(p.Asn453Ser)

TGCCCAGGAGGACTCAGACCAC′]

3609
NM_000095.2(COMP): c.1418A > G
1311
COMP
[′GGTGATGCCTGCGACGACGACGACGRCAA

(p.Asp473Gly)

TGACGGAGTCCCTGACAGTCGG′]

3610
NM_002047.2(GARS): c.374A > G
2617
GARS
[′GATATTGTAGACCGAGCAAAAATGGRAGA

(p.Glu125Gly)

TACCCTGAAGAGGAGGTTTTTC′]

3611
NM_001166107.1(HMGCS2):
3158
HMGCS2
[′GGCATAGATACCACCAATGCCTGCTRCGG

c.500A > G (p.Tyr167Cys)

TGGTACTGCCTCCCTCTTCAAT′]

3612
NM_000161.2(GCH1): c.671A > G
2643
GCH1
[′CGAGGTGTACAGAAAATGAACAGCARAAC

(p.Lys224Arg)

TGTGACCAGCACAATGTTGGGT′]

3613
NM_001024630.3(RUNX2):
860
RUNX2
[′ATCTGCAGGCAAGAGTTTCACCTTGRCCAT

c.598A > G (p.Thr200Ala)

AACCGTCTTCACAAATCCTCC′]

3614
NM_000423.2(KRT2): c.556A > G
3849
KRT2
[′AGAGCGTGAGCAGATCAAAACTCTCDACA

(p.Asn186Asp)

ACAAATTTGCCTCCTTCATTGA′]

3615
NM_000215.3(JAK3): c.299A > G
3718
JAK3
[′GATGCCAGCACCCAAGTCCTGCTGTRCAG

(p.Tyr100Cys)

GATTCGGTAGGAAGTGCCCCCC′]

3616
NM_000335.4(SCN5A):
6331
SCN5A
[′CTCTGTCCACTTGAGGTGGTGGTCARTGCC

c.3971A > G (p.Asn1324Ser)

CTGGTGGGCGCCATCCCGTCC′]

3617
NM_000335.4(SCN5A)
6331
SCN5A
[′AGTGAGGACGACTTCGATATGTTCTRTGAG

c.5381A > G (p.Tyr1794Cys)

ATCTGGGAGAAATTTGACCCA′]

3618
NM_001014797.2(KCNMA1):
3778
KCNMA1
[′AAGGACTTTCTGCACAAGGACCGGGRTGA

c.1301A > G (p.Asp434Gly)

CGTCAATGTGGAGATCGTTTTT′]

3619
NM_004380.2(CREBBP):
1387
CREBBP
[′TATAATCGCAAGACATCCCGAGTCTRTAA

c.3524A > G (p.Tyr1175Cys)

GTTTTGCAGTAAGCTTGCAGAG′]

3620
NM_000023.2(SGCA): c.410A > G
6442
SGCA
[′GGCCCCCTGCTGCCATACCAAGCCGRGTTC

(p.Glu137Gly)

CTGGTGCGCAGCCACGATGCG′]

3621
NM_002835.3(PTPN12):
5782
PTPN12
[′GGAGAAAAAGAAGAAAATGTTAAAARGA

c.182A > G (p.Lys61Arg)

ACAGATACAAGGACATACTGCCA′]

3622
NM_000211.4(ITGB2):
3689
ITGB2
[′GGGGAGCTGTCTGAGGACTCCAGCARTGT

c.1052A > G (p.Asn351Ser)

GGTCCAACTCATTAAGAATGCT′]

3623
NM_005502.3(ABCA1):
19
ABCA1
[′GTCTGGGGGGGCTTCGCCTACTTGCRGGAT

c.1790A > G (p.Gln597Arg)

GTGGTGGAGCAGGCAATCATC′]

3624
NM_005502.3(ABCA1):
19
ABCA1
[′CAGATCACCTCCTTCCTGGGCCACARTGGA

c.2804A > G (p.Asn935Ser)

GCGGGGAAGACGACCACCATG′]

3625
m.5843A > G
4579
MT-TY
[′CTCGGAGCTGGTAAAAAGAGGCCTARCCC

CTGTCTTTAGATTTACAGTCCA′]

3626
m.7445A > G
−1
—
[′AAGAACCCGTATACATAAAATCTAGVCAA

AAAAGGAAGGAATCGAACCCCC′]

3627
m.8344A > G
4566
MT-TK
[′ACCTTTTAAGTTAAAGATTAAGAGARCCA

ACACCTCTTTACAGTGAAATGC′]

3628
m.8296A > G
4566
MT-TK
[′ACCCCCTCTACCCCCTCTAGAGCCCRCTGT

AAAGCTAACTTAGCATTAACC′]

3629
m.12320A > G
4568
MT-TL2
[′TCTTAGGCCCCAAAAATTTTGGTGCRACTC

CAAATAAAAGTAATAACCATG′]

3630
m.3243A > G
4567
MT-TL1
[′AGAACAGGGTTTGTTAAGATGGCAGRGCC

CGGTAATCGCATAAAACTTAAA′]

3631
m.3252A > G
4567
MT-TL1
[′TTTGTTAAGATGGCAGAGCCCGGTARTCGC

ATAAAACTTAAAACTTTACAG′]

3632
m.3251A > G
4567
MT-TL1
[′GTTTGTTAAGATGGCAGAGCCCGGTRATC

GCATAAAACTTAAAACTTTACA′]

3633
m.3260A > G
4567
MT-TL1
[′GATGGCAGAGCCCGGTAATCGCATARAAC

TTAAAACTTTACAGTCAGAGGT′]

3634
m.3274A > G
4567
MT-TL1
[′GTAATCGCATAAAACTTAAAACTTTRCAGT

CAGAGGTTCAATTCCTCTTCT′]

3635
m.4317A > G
4565
MT-TI
[′GATAGAGTAAATAATAGGAGCTTAARCCC

CCTTATTTCTAGGACTATGAGA′]

3636
m.4269A > G
4565
MT-TI
[′GCATTCCCCCTCAAACCTAAGAAATRTGTC

TGATAAAAGAGTTACTTTGAT′]

3637
m.4295A > G
4565
MT-TI
[′TGTCTGATAAAAGAGTTACTTTGATRGAGT

AAATAATAGGAGCTTAAACCC′]

3638
m.4300A > G
4565
MT-TI
[′GATAAAAGAGTTACTTTGATAGAGTRAAT

AATAGGAGCTTAAACCCCCTTA′]

3639
m.10044A > G
4563
MT-TG
[′CTTCCAATTAACTAGTTTTGACAACRTTCA

AAAAAGAGTAATAAACTTCGC′]

3640
m.7526A > G
4555
MT-TD
[′TCCATGACTTTTTCAAAAAGGTATTRGAAA

AACCATTTCATAACTTTGTCA′]

3641
m.10438A > G
4573
MT-TR
[′AGTTTAAACAAAACGAATGATTTCGRCTC

ATTAAATTATGATAATCATATT′]

3642
m.1555A > G
4549
MT-RNR1
[′ACCCCTACGCATTTATATAGAGGAGRCAA

GTCGTAACATGGTAAGTGTACT′]

3643
m.827A > G
4549
MT-RNR1
[′CACCCCCACGGGAAACAGCAGTGATNARC

CTTTAGCAATAAACGAAAGTTT′]

3644
m.15579A > G
4519
MT-CYB
[′CCCGAATGATATTTCCTATTCGCCTRCACA

ATTCTCCGATCCGTCCCTAAC′]

3645
m.14495A > G
4541
MT-ND6
[′TCCAAAGACAACCATCATTCCCCCTRAATA

AATTAAAAAAACTATTAAACC′]

3646
m.12770A > G
4540
MT-ND5
[′CTATTCCAACTGTTCATCGGCTGAGRGGGC

GTAGGAATTATATCCTTCTTG′]

3647
m.11084A > G
4538
MT-ND4
[′CTCCCTACAAATCTCCTTAATTATARCATT

CACAGCCACAGAACTAATCAT′]

3648
m.3397A > G
4535
MT-ND1
[′TACCGAACGAAAAATTCTAGGCTATRTAC

AACTACGCAAAGGCCCCAACGT′]

3649
m.4136A > G
4535
MT-ND1
[′CTGTTCTTATGAATTCGAACAGCATRCCCC

CGATTCCGCTACGACCAACTC′]

3650
m.3796A > G
4535
MT-ND1
[′CCGTTTACTCAATCCTCTGATCAGGNTGAG

-

CATCAAACTCAAACTACGCCC′,

3654

′AATAAGTGGCTCCTTTAACCTCTCCDCCCTT

ATCACAACACAAGAACACCT′,

′ACCCCCTTGACCTTGCCGAAGGGGANTCCG

AACTAGTCTCAGGCTTCAACA′,

′CGAATACGCCGCAGGCCCCTTCGCCNTATT

CTTCATAGCCGAATACACAAA′,

′ATTTTGTCACCAAGACCCTACTTCTNACCTC

CCTGTTCTTATGAATTCGAA′]

3655
NM_003334.3(UBA1): c.1639A > G
7317
UBA1
[′AATGAATCCACATATCCGGGTGACARGCC

(p.Ser547Gly)

ACCAGAACCGTGTGGGTCCTGA′]

3656
NM_000354.5(SERPINA7):
6906
SERPINA7
[′GATCAAAAGGATTTGCCCACTGGGCYTAA

c.623 − 2A > G

AATACAAAGAAAAGAGAGGTGT′]

3657
NM_000044.3(AR): c.2291A > G
367
AR
[′ACCAATGTCAACTCCAGGATGCTCTRCTTC

(p.Tyr764Cys)

GCCCCTGATCTGGTTTTCAAT′]

3658
NM_000044.3(AR): c.2362A > G
367
AR
[′CCGGATGTACAGCCAGTGTGTCCGARTGA

(p.Met788Val)

GGCACCTCTCTCAAGAGTTTGG′]

3659
NM_000044.3(AR): c.2632A > G
367
AR
[′GATTGCGAGAGAGCTGCATCAGTTCRCTTT

(p.Thr878Ala)

TGACCTGCTAATCAAGTCACA′]

3660
NM_000044.3(AR): c.2708A > G
367
AR
[′ATGATGGCAGAGATCATCTCTGTGCRAGT

(p.Gln903Arg)

GCCCAAGATCCTTTCTGGGAAA′]

3661
NM_002764.3(PRPS1): c.341A > G
5631
PRPS1
[′CCAATCTCAGCCAAGCTTGTTGCAARTATG

(p.Asn114Ser)

CTATCTGTAGCAGGTGCAGAT′]

3662
NM_000194.2(HPRT1): c.602A > G
3251
HPRT1
[′CTTGACTATAATGAATACTTCAGGGRTTTG

(p.Asp201Gly)

AATGTAAGTAATTGCTTCTTT′]

3663
NM_000194.2(HPRT1): c.155A > G
3251
HPRT1
[′TGTAGGACTGAACGTCTTGCTCGAGRTGTG

(p.Asp52Gly)

ATGAAGGAGATGGGAGGCCAT′]

3664
NM_000132.3(F8): c.872A > G
2157
F8
[′CCTGAAGTGCACTCAATATTCCTCGRAGGT

(p.Glu291Gly)

CACACATTTCTTGTGAGGAAC′]

3665
NM_000132.3(F8): c.5183A > G
2157
F8
[′GCTGCAGTGGAGAGGCTCTGGGATTRTGG

(p.Tyr1728Cys)

GATGAGTAGCTCCCCACATGTT′]

3666
NM_000132.3(F8): c.5821A > G
2157
F8
[′TTCTCTGTGTCCTTCTCCAGCAATCRATGG

(p.Asn1941Asp)

CTACATAATGGATACACTACC′]

3667
NM_000132.3(F8): c.328A > G
2157
F8
[′TACAGTGGTCATTACACTTAAGAACRTGGC

(p.Met110Val)

TTCCCATCCTGTCAGTCTTCA′]

3668
NM_000132.3(F8): c.398A > G
2157
F8
[′TTTCTTCCTGCTATAGGAGCTGAATRTGAT

(p.Tyr133Cys)

GATCAGACCAGTCAAAGGGAG′]

3669
NM_000132.3(F8): c.404A > G
2157
F8
[′CCTGCTATAGGAGCTGAATATGATGRTCA

(p.Asp135Gly)

GACCAGTCAAAGGGAGAAAGAA′]

3670
NM_000132.3(F8): c.940A > G
2157
F8
[′GGAAATCTCGCCAATAACTTTCCTTRCTGC

(p.Thr314Ala)

TCAAACACTCTTGATGGACCT′]

3671
NM_000132.3(F8): c.1226A > G
2157
F8
[′TGGGTACATTACATTGCTGCTGAAGRGGA

(p.Glu409Gly)

GGACTGGGACTATGCTCCCTTA′]

3672
NM_000132.3(F8): c.1331A > G
2157
F8
[′CAGCGGATTGGTAGGAAGTACAAAARAGT

(p.Lys444Arg)

CCGATTTATGGCATACACAGAT′]

3673
NM_000132.3(F8): c.1418A > G
2157
F8
[′TCAGGAATCTTGGGACCTTTACTTTRTGGG

(p.Tyr473Cys)

GAAGTTGGAGACACACTGTTG′]

3674
NM_000132.3(F8): c.1660A > G
2157
F8
[′TCGGTGCCTGACCCGCTATTACTCTRGTTT

(p.Ser554Gly)

CGTTAATATGGAGAGAGATCT′]

3675
NM_000132.3(F8): c.1682A > G
2157
F8
[′TCTAGTTTCGTTAATATGGAGAGAGRTCTA

(p.Asp561Gly)

GCTTCAGGACTCATTGGCCCT′]

3676
NM_000132.3(F8): c.1892A > G
2157
F8
[′GAGGATCCAGAGTTCCAAGCCTCCARCAT

(p.Asn631Ser)

CATGCACAGTGAGTAAAGCAGC′]

3677
NM_000132.3(F8): c.5600A > G
2157
F8
[′TTCCCTCCCTAGGAAAAAGATGTGCRCTCA

(p.His1867Arg)

GGCCTGATTGGACCCCTTCTG′]

3678
NM_000132.3(F8): c.5822A > G
2157
F8
[′TCTCTGTGTCCTTCTCCAGCAATCARTGGC

(p.Asn1941Ser)

TACATAATGGATACACTACCT′]

3679
NM_000132.3(F8): c.6113A > G
2157
F8
[′AGCACACTTTTTCTGGTGTACAGCARTAGT

(p.Asn2038Ser)

GAGTAGCAATGTGGGCAGAGG′]

3680
NM_000132.3(F8): c.6278A > G
2157
F8
[′AAGTGTTATTTTAATTGGTAGGTGGRTCTG

(p.Asp2093Gly)

TTGGCACCAATGATTATTCAC′]

3681
NM_000132.3(F8): c.6371A > G
2157
F8
[′TACATCTCTCAGTTTATCATCATGTRTAGT

CTTGATGGGAAGAAGTGGCAG′]

3682
NM_000132.3(F8): c.6794A > G
2157
F8
[′ATGAAAGTCACAGGAGTAACTACTCRGGG

(p.Gln2265Arg)

AGTAAAATCTCTGCTTACCAGC′]

3683
NM_000132.3(F8): c.104A > G
2157
F8
[′GGTGCAGTGGAACTGTCATGGGACTRTAT

(p.Tyr35Cys)

GCAAAGTGATCTCGGTGAGCTG′]

3684
NM_000402.4(G6PD): c.466A > G
2539
G6PD
[′CAACTCCTATGTGGCTGGCCAGTACRATGA

(p.Asn156Asp)

TGCAGCCTCCTACCAGCGCCT′]

3685
NM_000402.4(G6PD): c.583A > G
2539
G6PD
[′GCTCCGGGCTCCCAGCAGAGGCTGGRACC

(p.Asn195Asp)

GCATCATCGTGGAGAAGCCCTT′]

3686
NM_002049.3(GATA1): c.653A > G
2623
GATA1
[′ACAGCCACTCCACTGTGGCGGAGGGRCAG

(p.Asp218Gly)

GACAGGCCACTACCTATGCAAC′]

3687
NM_001097642.2(GJB1):
2705
GJB1
[′CAGCCTGGCTGCAACAGCGTTTGCTRTGAC

c.194A > G (p.Tyr65Cys)

CAATTCTTCCCCATCTCCCAT′]

3688
NM_000166.5(GJB1): c.614A > G
2705
GJB1
[′GCCTCTGGCATCTGCATCATCCTCARTGTG

(p.Asn205Ser)

GCCGAGGTGGTGTACCTCATC′]

3689
NM_000032.4(ALAS2):
212
ALAS2
[′CCGTCCTGTACACTTTGAGCTCATGRGTGA

c.1702A > G (p.Ser568Gly)

GTGGGAACGTTCCTACTTCGG′]

3690
NM_000202.6(IDS): c.404A > G
3423
IDS
[′GGCTATGTGACCATGTCGGTGGGAARAGT

(p.Lys135Arg)

CTTTCACCCTGGTACTGCTCCA′]

3691
NM_000292.2(PHKA2): c.896A > G
5256
PHKA2
[′TATGGATGCTGTCGCTTCCTTCGAGRTGGT

(p.Asp299Gly)

TATAAAACTCCAAGAGAGGTT′]

3692
NM_000292.2(PHKA2): c.565A > G
5256
PHKA2
[′TTATGGAATGTGGGAGCGTGGAGATRAGA

(p.Lys189Glu)

CTAATCAGGGCATCCCGGAATT′]

3693
NM_000351.4(STS): c.1331A > G
412
STS
[′CGCTCCGATCATGAGTTTCTCTTCCRTTAC

(p.His444Arg)

TGCAACGCCTACTTAAATGCT′]

3694
NM_000133.3(F9): c.278A > G
2158
F9
[′TTCAATTTCTTAACCTATCTCAAAGRTGGA

(p.Asp93Gly)

GATCAGTGTGAGTCCAATCCA′]

3695
NM_000133.3(F9): c.329A > G
2158
F9
[′TGTTTAAATGGCGGCAGTTGCAAGGRTGA

(p.Asp110Gly)

CATTAATTCCTATGAATGTTGG′]

3696
NM_000133.3(F9): c.917A > G
2158
F9
[′CGAATTATTCCTCACCACAACTACARTGCA

(p.Asn306Ser)

GCTATTAATAAGTACAACCAT′]

3697
NM_000133.3(F9): c.1180A > G
2158
F9
[′TACAAAGTTCACCATCTATAACAACRTGTT

(p.Met394Val)

CTGTGCTGGCTTCCATGAAGG′]

3698
NM_000133.3(F9): c.1231A > G
2158
F9
[′AGGTAGAGATTCATGTCAAGGAGATRGTG

(p.Ser411Gly)

GGGGACCCCATGTTACTGAAGT′]

3699
NM_000266.3(NDP): c.131A > G
4693
NDP
[′CCTCGACGCTGCATGAGGCACCACTRTGTG

(p.Tyr44Cys)

GATTCTATCAGTCACCCATTG′]

3700
NM_000266.3(NDP): c.1A > G
4693
NDP
[′TCTAGAGAAGTTTTTCCTTACAACARTGAG

(p.Met1Val)

AAAACATGTACTAGCTGCATC′]

3701
NM_000266.3(NDP): c.125A > G
4693
NDP
[′TCGGACCCTCGACGCTGCATGAGGCRCCA

(p.His42Arg)

CTATGTGGATTCTATCAGTCAC′]

3702
NM_000169.2(GLA): c.886A > G
−1
—
[′GGCTATCATGGCTGCTCCTTTATTCRTGTC

(p.Met296Val)

TAATGACCTCCGACACATCAG′]

3703
NM_000169.2(GLA): c.101A > G
−1
—
[′ATCCCTGGGGCTAGAGCACTGGACARTGG

(p.Asn34Ser)

ATTGGCAAGGACGCCTACCATG′]

3704
NM_000169.2(GLA): c.644A > G
−1
—
[′GAGTCATATCTGTTTTCACAGCCCARTTAT

(p.Asn215Ser)

ACAGAAATCCGACAGTACTGC′]

3705
NM_000169.2(GLA): c.1228A > G
−1
—
[′AAGGTTAAGAAGTCACATAAATCCCRCAG

(p.Thr410Ala)

GCACTGTTTTGCTTCAGCTAGA′]

3706
NM_000169.2(GLA): c.815A > G
−1
—
[′TCTTTTTCTCAGTTAGTGATTGGCARCTTTG

(p.Asn272Ser)

GCCTCAGCTGGAATCAGCAA′]

3707
NM_153252.4(BRWD3):
254065
BRWD3
[′AGAAGATAAAGAGAAAAAAGAAACARAA

c.4786A > G (p.Lys1596Glu)

GAGAAATCTCATTTATCCACCTC′]

3708
NM_004463.2(FGD1): c.1396A > G
2245
FGD1
[′GCAGAAACTGGCCCCCTTCCTCAAGRTGTA

(p.Met466Val)

TGGTGAGTATGTGAAGAACTT′]

3709
NM_000054.4(AVPR2): c.614A > G
554
AVPR2
[′GCGGAGCCCTGGGGCCGTCGCACCTRTGT

(p.Tyr205Cys)

CACCTGGATTGCCCTGATGGTG′]

3710
NM_000054.4(AVPR2): c.839A > G
554
AVPR2
[′ATGACGCTAGTGATTGTGGTCGTCTRTGTG

(p.Tyr280Cys)

CTGTGCTGGGCACCCTTCTTC′]

3711
NM_000276.3(OCRL): c.1436A > G
4952
OCRL
[′ATCAAGTTCATCCCCACTTATAAGTRTGAC

(p.Tyr479Cys)

TCTAAAACAGACCGGTGGGAT′]

3712
NM_000397.3(CYBB): c.302A > G
1536
CYBB
[′CAACTGGACAGGAATCTCACCTTTCRTAAA

(p.His101Arg)

ATGGTGGCATGGATGATTGCA′]

3713
NM_000397.3(CYBB): c.1499A > G
1536
CYBB
[′GCTGTGCACCATGATGAGGAGAAAGRTGT

(p.Asp500Gly)

GATCACAGGCCTGAAACAAAAG′]

3714
NM_001205019.1(GK): c.880A > G
2710
GK
[′TGGAACAGGATGTTTCTTACTATGTRATAC

(p.Asn294Asp)

AGGCCATAAGGTTGGTTTTTT′]

3715
NM_005710.2(PQBP1): c.194A > G
10084
PQBP1
[′CGGCCCCACAGCGGGCTCCCTTACTRCTGG

(p.Tyr65Cys)

AATGCAGACACAGACCTTGTA′]

3716
NM_198270.3(NHS):
4810
NHS
[′CTGAACCTGATTGTACTTTGTTTGCRGTCC

c.853 − 2A > G

CATCCCCCAGAGGATGAAGAT′]

3717
NM_000252.2(MTM1): c.566A > G
4534
MTM1
[′CACCATTGGAGAATAACTTTTATTARTAAG

(p.Asn189Ser)

TGCTATGAGCTCTGTGACACT′]

3718
NM_000252.2(MTM1): c.1190A > G
4534
MTM1
[′GCCATGCTGATGTTGGATAGCTTCTRTAGG

(p.Tyr397Cys)

AGCATTGAAGGGTTCGAAATA′]

3719
NM_000252.2(MTM1):
4534
MTM1
[′TAATTAAAACAAATTATCTTCATCARTTTA

c.1261 − 10A > G

TTCAGCGAATAGGTCATGGTG′]

3720
NM_001015877.1(PHF6):
84295
PHF6
[′AGGAAAACTGCATATATTTAATGCCRAGA

c.700A > G (p.Lys234Glu)

AGGCAGCTGCCCATTATAAGTG′]

3721
NM_001015877.1(PHF6):
84295
PHF6
[′GAAAATGAAGCACGAGGAAAACTGCRTAT

c.686A > G (p.His229Arg)

ATTTAATGCCAAGAAGGCAGCT′]

3722
NM_001015877.1(PHF6):
84295
PHF6
[′CACAGTCCAGCTCACAACAACATCARGAG

c.769A > G (p.Arg257Gly)

CAGAATTTGGAGACTTTGATAT′]

3723
NM_000117.2(EMD): c.1A > G
2010
EMD
[′GCCTCCGCCTGAGCCCGCACCCGCCRTGG

(p.Met1Val)

ACAACTACGCAGATCTTTCGGA′]

3724
NM_004006.2(DMD): c.2317A > G
1756
DMD
[′GGCCATAGAGCGAGAAAAAGCTGAGRAGT

(p.Lys773Glu)

TCAGAAAACTGCAAGATGCCAG′]

3725
NM_004006.2(DMD): c.8734A > G
1756
DMD
[′TCTACGAAAGCAGGCTGAGGAGGTCRATA

(p.Asn2912Asp)

CTGAGTGGGAAAAATTGAACCT′]

3726
NM_004006.2(DMD): c.8762A > G
1756
DMD
[′ACTGAGTGGGAAAAATTGAACCTGCRCTC

(p.His2921Arg)

CGCTGACTGGCAGAGAAAAATA′]

3727
NM_004006.2(DMD): c.835A > G
1756
DMD
[′TCCCCCAAACCCTTCTCTGCAGATCRCGGT

(p.Thr279Ala)

CAGTCTAGCACAGGGATATGA′]

3728
NM_004006.2(DMD):
1756
DMD
[′TCGATCGCACTTCAGTTATGATAAAYTGAC

c.9225 − 285A > G

CTTGTTATGTGATCAATAATC′]

3729
NM_000033.3(ABCD1): c.443A > G
215
ABCD1
[′ATCGCCCTCCCTGCTACCTTCGTCARCAGT

(p.Asn148Ser)

GCCATCCGTTACCTGGAGGGC′]

3730
NM_003588.3(CUL4B):
8450
CUL4B
[′TTTGATTTCTTTTTTTTTCATTGGCRGATCA

c.901 − 2A > G

TGATCAGGAGCATTTTTTTG′]

3731
NM_000061.2(BTK): c.1288A > G
695
BTK
[′GAGAGGCCAGTACGACGTGGCCATCRAGA

(p.Lys430Glu)

TGATCAAAGAAGGCTCCATGTC′]

3732
NM_000061.2(BTK): c.1082A > G
695
BTK
[′AGCACCATCCCTGAGCTCATTAACTRCCAT

(p.Tyr361Cys)

CAGCACAACTCTGCAGGTGAG′]

3733
NM_000061.2(BTK): c.919A > G
695
BTK
[′GGGGAAAGAAGGAGGTTTCATTGTCRGAG

(p.Arg307Gly)

ACTCCAGCAAAGCTGGCAAATA′]

3734
NM_000061.2(BTK): c.1766A > G
695
BTK
[′CACCTTCTAGGGGTTTTGATGTGGGRAATT

(p.Glu589Gly)

TACTCCCTGGGGAAGATGCCA′]

3735
NM_003413.3(ZIC3): c.1213A > G
7547
ZIC3
[′CTACACGCACCCGAGCTCCCTGCGCRAAC

(p.Lys405Glu)

ACATGAAGGTAATTACCTCTTT′]

3736
NM_001037811.2(HSD17B10):
3028
HSD17B10
[′GCCATCATCGAGAACCCATTCCTCARTGGA

c.713A > G (p.Asn238Ser)

GAGGTCATCCGGCTGGATGGG′]

3737
NM_003639.4(IKBKG):
8517
IKBKG
[′CAAGTGCCAGTATCAGGCCCCTGATRTGG

c.1219A > G (p.Met407Val)

ACACCCTGCAGATACATGTCAT′]

3738
NM_003639.4(IKBKG):
8517
IKBKG
[′ATACATGTCATGGAGTGCATTGAGTRGGG

c.1259A > G (p.Ter420Trp)

CCGGCCAGTGCAAGGCCACTGC′]

3739
NM_005448.2(BMP15): c.704A > G
9210
BMP15
[′TTGGACATTGCCTTCTTGTTACTCTRTTTCA

(p.Tyr235Cys)

ATGATACTCATAAAAGCATT′]

3740
NM_005120.2(MED12):
9968
MED12
[′AAGGTGAAGAACACCATCTACTGCARCGT

c.3020A > G (p.Asn1007Ser)

GGAGCCATCGGAATCAAATATG′]

3741
NM_003688.3(CASK): c.2129A > G
8573
CASK
[′GGCAAGAAAAAGAAGCAGTACAAAGRTA

(p.Asp710Gly)

AATATTTGGCAAAGCACAATGCA′]

3742
NM_001363.4(DKC1): c.361A > G
1736
DKC1
[′ACTTCGGGTGGAGAAGACAGGGCACRGTG

(p.Ser121Gly)

GTACTCTGGATCCCAAGGTGAC′]

3743
NM_001363.4(DKC1): c.1069A > G
1736
DKC1
[′ATTAATGACCACAGCGGTCATCTCTRCCTG

(p.Thr357Ala)

CGACCATGGTATAGTAGCCAA′]

3744
NM_000307.4(POU3F4):
5456
POU3F4
[′GTTCTGTAATCGAAGACAAAAAGAGRAAA

c.1000A > G (p.Lys334Glu)

GAATGACTCCGCCAGGGGATCA′]

3745
NM_004429.4(EFNB1): c.472A > G
1947
EFNB1
[′GGGCGGTGTGTGCCGCACACGCACCRTGA

(p.Met158Val)

AGATCATCATGAAGGTTGGGCA′]

3746
NM_000489.4(ATRX): c.4826A > G
546
ATRX
[′TTCTTATAGGTGGTAAGTTTTCTTCRTACA

(p.His1609Arg)

GTTCTTTTGTGTGACAAACTG′]

3747
NM_000489.4(ATRX): c.5579A > G
546
ATRX
[′TTCTTTTGATCAGGTGTGGGCAATAVTAGT

(p.Asn1860Ser)

GAAGGTGGAAGAGGAAAGGCA′]

3748
NM_000489.4(ATRX): c.6488A > G
546
ATRX
[′GGACAAACTAAGCCTGTTTATGTATRTAGG

(p.Tyr2163Cys)

TTCTTAGCTCAGGTAGGTTTA′]

3749
NM_000489.4(ATRX): c.6811A > G
546
ATRX
[′AGAAGAAGAGTTGACTGAAGAAGAARGA

(p.Arg2271Gly)

AAAGCAGCTTGGGCTGAGTATGA′]

3750
NM_000052.6(ATP7A): c.3911A > G
538
ATP7A
[′GTAGCAATGGTGGGAGATGGAATCARTGA

(p.Asn1304Ser)

CTCCCCAGCTCTGGCAATGGCT′]

3751
NM_004992.3(MECP2): c.410A > G
4204
MECP2
[′GGAAAAGCCTTTCGCTCTAAAGTGGRGTT

(p.Glu137Gly)

GATTGCGTACTTCGAAAAGGTA′]

3752
NM_000137.2(FAH): c.1141A > G
2184
FAH
[′CATAGACCTGGGGAATGGTCAGACCRGGA

(p.Arg381Gly)

AGTTTCTGCTGGACGGGGATGA′]

3753
NM_000137.2(FAH): c.836A > G
2184
FAH
[′CCCTTTGCTGTGCCCAACCCGAAGCRGGTA

(p.Gln279Arg)

AGCACATTCTCTGCAGGAAGC′]

3754
NM_002769.4(PRSS1): c.68A > G
−1
—
[′GCTGCCCCCTTTGATGATGATGACARGATC

(p.Lys23Arg)

GTTGGGGGCTACAACTGTGAG′]

3755
NM_002769.4(PRSS1): c.161A > G
−1
—
[′CACTTCTGTGGTGGCTCCCTCATCARCGAA

(p.Asn54Ser)

CAGTGGGTGGTATCAGCAGGC′]

3756
NM_000373.3(UMPS): c.286A > G
7372
UMPS
[′AACCAATCAAATTCCAATGCTTATTRGAAG

(p.Arg96Gly)

GAAAGAAACAAAGGATTATGG′]

3757
NM_001918.3(DBT): c.1355A > G
1629
DBT
[′ATGAATGTGAGCTGGTCAGCTGATCRCAG

(p.His452Arg)

AGTTATTGATGGTGCTACAATG′]

3758
NM_000108.4(DLD): c.214A > G
1738
DLD
[′TTGGTTGTAGACAGTCTGCATTGAGRAAA

(p.Lys72Glu)

ATGAAACACTTGGTGGAACATG′]

3759
NM_000108.4(DLD): c.1483A > G
1738
DLD
[′CTTGCAGACCTTATCAGAAGCTTTTRGAGA

(p.Arg495Gly)

AGCAAATCTTGCTGCGTCATT′]

3760
NM_000108.4(DLD): c.1081A > G
1738
DLD
[′CATTGGTGATGTAGTTGCTGGTCCARTGCT

(p.Met361 Val)

GGCTCACAAAGCAGAGGATGA′]

3761
NM_000481.3(AMT): c.125A > G
275
AMT
[′CGCAGGACACCGCTCTATGACTTCCRCCTG

(p.His42Arg)

GCCCACGGCGGGAAAATGGTG′]

3762
NM_000151.3(G6PC):
2538
G6PC
[′GGCTCAACCTCGTCTTTAAGTGGTARGAAC

c.230 + 4A > G

CATATAGAGAGGAGATCAGCA′]

3763
NM_000532.4(PCCB): c.1304A > G
5096
PCCB
[′CAGCATTTGGATCTGTTTTAGGCCTRTGGA

(p.Tyr435Cys)

GGTGCCTATGATGTCATGAGC′]

3764
NM_000387.5(SLC25A20):
788
SLC25A20
[′CCAGATGTGCTCAAGTCTCGATTCCRGACT

c.713A > G (p.Gln238Arg)

GGTGAGTGGAAGGTAGTGGGG′]

3765
NM_004360.3(CDH1): c.2512A > G
999
CDH1
[′TCTGCTCGTGTTTGACTATGAAGGARGCGG

(p.Ser838Gly)

TTCCGAAGCTGCTAGTCTGAG′]

3766
NM_004360.3(CDH1): c.1018A > G
999
CDH1
[′GTCGATCTCTCTGCAGAGTTTCCCTDCGTA

(p.Thr340Ala)

TACCCTGGTGGTTCAAGCTGC′]

3767
NM_003361.3(UMOD): c.383A > G
7369
UMOD
[′TGCCACGCCCTGGCCACATGTGTCARTGTG

(p.Asn128Ser)

GTGGGCAGCTACTTGTGCGTA′]

3768
NM_000463.2(UGT1A1):
−1
—
[′GCTGATGCTTTGGGCAAAATCCCTCRGACA

c.992A > G (p.Gln331Arg)

GTAAGAAGATTCTATACCATG′]

3769
NM_000463.2(UGT1A1):
−1
—
[′TGACATCCTCCCTATTTTGCATCTCRGGTC

c.1085 − 2A > G

ACCCGATGACCCGTGCCTTTA′]

3770
NM_000463.2(UGT1A1): c.1070A >
−1
—
[′ACGATACTTGTTAAGTGGCTACCCCRAAAC

G (p.Gln357Arg)

GATCTGCTTGGTATGTTGGGC′]

3771
NM_000463.2(UGT1A1): c.1198A >
−1
—
[′GCCCTTGTTTGGTGATCAGATGGACVATGC

G (p.Asn400Asp)

AAAGCGCATGGAGACTAAGGG′]

3772
NM_001382.3(DPAGT1):
1798
DPAGT1
[′TCTCTCCCCGCAGGAATCCTGTACTRTGTC

c.509A > G (p.Tyr170Cys)

TACATGGGGCTGCTGGCAGTG′]

3773
NM_001007792.1(NTRK1):
4914
NTRK1
[′CCCACCCACGTCAACAACGGCAACTRCAC

c.986A > G (p.Tyr329Cys)

GCTGCTGGCTGCCAACCCCTTC′]

3774
NM_001007792.1(NTRK1):
4914
NTRK1
[′CTGCACCGAGGGCCGCCCCCTGCTCRTGGT

c.1651A > G (p.Met551 Val)

CTTTGAGTATATGCGGCACGG′]

3775
NM_000363.4(TNNI3): c.569A > G
7137
TNNI3
[′CTCCAGGAAAACCGGGAGGTGGGAGRCTG

(p.Asp190Gly)

GCGCAAGAACATCGATGCACTG′]

3776
NM_000363.4(TNNI3): c.532A > G
7137
TNNI3
[′GCGGGCCCACCTCAAGCAGGTGAAGRAGG

(p.Lys178Glu)

AGGACACCGAGAAGGTGAGTGT′]

3777
NM_001018005.1(TPM1):
7168
TPM1
[′ATTGAGAGCGACCTGGAACGTGCAGDGGA

c.539A > G (p.Glu180Gly)

GCGGGCTGAGCTCTCAGAAGGG′]

3778
NM_001159287.1(TPI1):
7167
TPI1
[′CCTGGCCTATGAGCCTGTGTGGGCCRTTGG

c.622A > G (p.Ile208Val)

TACTGGCAAGACTGCAACACC′]

3779
NM_000359.2(TGM1): c.1469A > G
7051
TGM1
[′AATGGCCTGGTCTACATGAAGTACGRCAC

(p.Asp490Gly)

GCCTTTCATTTTTGCTGAGGTG′]

3780
NM_001024847.2(TGFBR2):
7048
TGFBR2
[′CCCTGTGTTTGCTGGCTTTCTTCACRGAAG

c.1472 − 2A > G

TAAAAGATTATGAGCCTCCAT′]

3781
NM_003242.5(TGFBR2):
7048
TGFBR2
[′GCTATAGGTGGGAACTGCAAGATACRTGG

c.1273A > G (p.Met425Val)

CTCCAGAAGTCCTAGAATCCAG′]

3782
NM_004612.3(TGFBR1):
7046
TGFBR1
[′CATTTTGAATCCTTCAAACGTGCTGRCATC

c.1199A > G (p.Asp400Gly)

TATGCAATGGGCTTAGTATTC′]

3783
NM_001128177.1(THRB):
7068
THRB
[′CTGCCATGCCAGCCGCTTCCTGCACRTGAA

c.1324A > G (p.Met442Val)

GGTGGAATGCCCCACAGAACT′]

3784
NM_001128177.1(THRB):
7068
THRB
[′CCATGCCAGCCGCTTCCTGCACATGRAGGT

c.1327A > G (p.Lys443Glu)

GGAATGCCCCACAGAACTCTT′]

3785
NM_001128177.1(THRB):
7068
THRB
[′AACCTTGAATGGGGAAATGGCAGTGRCAC

c.1009A > G (p.Thr337Ala)

GGGGCCAGCTGAAAAATGGGGG′]

3786
NM_033360.3(KRAS): c.13A > G
3845
KRAS
[′AGGCCTGCTGAAAATGACTGAATATRAAC

(p.Lys5Glu)

TTGTGGTAGTTGGAGCTGGTGG′]

3787
NM_005343.2(HRAS): c.350A > G
−1
—
[′GTGCCCATGGTGCTGGTGGGGAACARGTG

(p.Lys117Arg)

TGACCTGGCTGCACGCACTGTG′]

3788
NM_001063.3(TF): c.956A > G
7018
TF
[′GACCTGCTGTTTAAGGACTCTGCCCRCGGG

(p.His319Arg)

TTTTTAAAAGTCCCCCCCAGG′]

3789
NM_001063.3(TF): c.1936A > G
7018
TF
[′CTTTTGTTTGTTCCGGTCGGAAACCRAGGA

(p.Lys646Glu)

CCTTCTGTTCAGAGATGACAC′]

3790
NM_212472.2(PRKAR1A):
5573
PRKAR1A
[′ATGAGTTCTTCATTATTTTAGAGGTRAAGA

c.891+ 3A > G

ACTCAGAATTTAATACTTGAA′]

3791
NM_212472.2(PRKAR1A): c.1A > G
5573
PRKAR1A
[′GTGTGTTTTTTTCTCGCAGAGAACCRTGGA

(p.Met1Val)

GTCTGGCAGTACCGCCGCCAG′]

3792
NM_000362.4(TIMP3): c.572A > G
−1
—
[′GCCTGCATCCGGCAGAAGGGCGGCTRCTG

(p.Tyr191Cys)

CAGCTGGTACCGAGGATGGGCC′]

3793
NM_000367.3(TPMT): c.719A > G
7172
TPMT
[′GATTACAGGTGTGAGCCACCGCACCNAGC

-
(p.Tyr240Cys)

CAATTTTGAGTATTTTTAAAAG′,

3795

′TAACATGTTACTCTTTCTTGTTTCARGTAAA

ATATGCAATATACRTYGTCT′,

′AGGTTGATGCTTTTGAAGAACGACAKAAAA

GTTGGGGAATTGACTGTCTTT′]

3796
NM_198253.2(TERT): c.2315A > G
7015
TERT
[′TCTACCTTGACAGACCTCCAGCCGTRCATG

(p.Tyr772Cys)

CGACAGTTCGTGGCTCACCTG′]

3797
NM_000073.2(CD3G): c.1A > G
917
CD3G
[′CTTTTGCCGGAGGACAGAGACTGACRTGG

(p.Met1Val)

AACAGGGGAAGGGCCTGGCTGT′]

3798
NM_000899.4(KITLG): c.107A > G
4254
KITLG
[′ATCTGCAGGAATCGTGTGACTAATARTGTA

(p.Asn36Ser)

AAAGACGTCACTAAATTGGTA′]

3799
NM_001024858.2(SPTB): c.1A > G
6710
SPTB
[′GCGGAGCTGCTAAGAGCCTGCTGACRTGA

(p.Met1Val)

CATCGGCCACAGAGTTTGAAAA′]

3800
NM_003126.2(SPTA1): c.143A > G
6708
SPTA1
[′GAGCGGGTCGCTGAGAGGGGTCAGARGCT

(p.Lys48Arg)

TGAGGATTCCTATCACTTACAA′]

3801
NM_005633.3(SOS1): c.1654A > G
6654
SOS1
[′TTTACAGTACCGGAGTACACTGGAARGGA

(p.Arg552Gly)

TGCTTGATGTAACAATGCTACA′]

3802
NM_003041.3(SLC5A2):
−1
—
[′GACCCGAGCTGGGCCCGTGTGGTCARCCT

c.1961A > G (p.Asn654Ser)

CAATGCCCTGCTCATGATGGCA′]

3803
NM_000343.3(SLC5A1): c.83A > G
6523
SLC5A1
[′CACGAGCTCATTCGCAATGCAGCCGRTATC

(p.Asp28Gly)

TCCATCATCGTTATCTACTTC′]

3804
NM_000702.3(ATP1A2):
477
ATP1A2
[′TCTCTACCAGGTGTGCCTGACCCTGRCAGC

c.1033A > G (p.Thr345Ala)

CAAGCGCATGGCACGGAAGAA′]

3805
NM_003124.4(SPR): c.448A > G
6697
SPR
[′CTTCCCGGACAGTCCTGGCCTCAACRGAAC

(p.Arg150Gly)

CGTGGTTAACATCTCGTCCCT′]

3806
NM_001161766.1(AHCY):
191
AHCY
[′CTCACCAACCTCATCCACACCAAGTRCCCG

c.344A > G (p.Tyr115Cys)

CAGCTTCTGCCAGGTGAGCAG′]

3807
NM_001035.2(RYR2):
6262
RYR2
[′TGCGAGGACACCATCTTTGAAATGCRGCT

c.12602A > G (p.Gln4201Arg)

GGCGGCTCAGATCTCGGAGTCG′]

3808
NM_000540.2(RYR1):
6261
RYR1
[′CAGTCCTTCCTGTACCTGGGCTGGTRTATG

c.14387A > G (p.Tyr4796Cys)

GTGATGTCCCTCTTGGGACAC′]

3809
NM_000540.2(RYR1):
6261
RYR1
[′CTCTGTCTCAAAAAAAAAAAAAAACRTAT

c.14647 − 1449A > G

GTAAAGTTGTTCCCAAATGCCA′]

3810
NM_000540.2(RYR1):
6261
RYR1
[′GGTGTACTACTTCCTGGAGGAAAGCRCAG

c.13909A > G (p.Thr4637Ala)

GCTACATGGAACCCGCCCTGCG′]

3811
NM_000539.3(RHO): c.533A > G
6010
RHO
[′TCTCCCTACCTGCCTGTCCTCAGGTRCATC

(p.Tyr178Cys)

CCCGAGGGCCTGCAGTGCTCG′]

3812
NM_000539.3(RHO): c.569A > G
6010
RHO
[′GGCCTGCAGTGCTCGTGTGGAATCGRCTAC

(p.Asp190Gly)

TACACGCTCAAGCCGGAGGTC′]

3813
NM_000539.3(RHO): c.886A > G
6010
RHO
[′CATGACCATCCCAGCGTTCTTTGCCRAGAG

(p.Lys296Glu)

CGCCGCCATCTACAACCCTGT′]

3814
NM_000539.3(RHO): c.44A > G
6010
RHO
[′CCTAACTTCTACGTGCCCTTCTCCARTGCG

(p.Asn15Ser)

ACGGGTGTGGTACGCAGCCCC′]

3815
NM_000321.2(RB1):
5925
RB1
[′AAGGGTGCTGTGGATCAGGGAAATGRTGA

c.2490 − 1398A > G

GTATGAAGCTGTTTTAAATTCT′]

3816
NM_000536.3(RAG2): c.115A > G
5897
RAG2
[′CTTTGGACAAAAAGGCTGGCCCAAARGAT

(p.Arg39Gly)

CCTGCCCCACTGGAGTTTTCCA′]

3817
NM_000448.2(RAG1): c.2735A > G
5896
RAG1
[′GAGTGCCCAGAATCCCTCTGCCAGTRCAGT

(p.Tyr912Cys)

TTCAATTCACAGCGTTTTGCT′]

3818
NM_000448.2(RAG1): c.1286A > G
5896
RAG1
[′TTTGCTGACAAAGAAGAAGGTGGAGRTGT

(p.Asp429Gly)

GAAGTCCGTGTGCATGACCTTG′]

3819
NM_000925.3(PDHB): c.395A > G
5162
PDHB
[′ATAAACTCAGCTGCCAAGACCTACTRCAT

(p.Tyr132Cys)

GTCTGGTGGCCTTCAGCCTGTG′]

3820
NM_000055.2(BCHE): c.293A > G
590
BCHE
[′GCAAATTCTTGCTGTCAGAACATAGRTCAA

(p.Asp98Gly)

AGTTTTCCAGGCTTCCATGGA′]

3821
NM_000055.2(BCHE): c.467A > G
590
BCHE
[′ACTGGAACATCATCTTTACATGTTTDTGAT

(p.Tyr156Cys)

GGCAAGTTTCTGGCTCGGGTT′]

3822
NM_005360.4(MAF): c.890A > G
4094
MAF
[′CTGAAGCAGAAGAGGCGGACCCTGARAAA

(p.Lys297Arg)

CCGCGGCTATGCCCAGTCCTGC′]

3823
NM_002739.3(PRKCG): c.380A > G
5582
PRKCG
[′TCCCTCCTCTACGGGCTTGTGCACCRGGGC

(p.Gln127Arg)

ATGAAATGCTCCTGTGAGTGA′]

3824
NM_002739.3(PRKCG):
5582
PRKCG
[′CTTCCTCATGGTTCTAGGAAAAGGCRGTTT

c.1081A > G (p.Ser361Gly)

TGGGAAGGTTGGATTCCTGGG′]

3825
NM_000141.4(FGFR2): c.983A > G
2263
FGFR2
[′ACGGACAAAGAGATTGAGGTTCTCTRTATT

(p.Tyr328Cys)

CGGAATGTAACTTTTGAGGAC′]

3826
NM_000141.4(FGFR2):
2263
FGFR2
[′AAGGAGATTACAGCTTCCCCAGACTRCCT

c.1124A > G (p.Tyr375Cys)

GGAGATAGCCATTTACTGCATA′]

3827
NM_000141.4(FGFR2): c.874A > G
2263
FGFR2
[′TGCCCAGCCCCACATCCAGTGGATCRAGC

(p.Lys292Glu)

ACGTGGAAAAGAACGGCAGTAA′]

3828
NM_000141.4(FGFR2):
2263
FGFR2
[′ACTGTTCATAGATGATGCCACAGAGRAAG

c.1576A > G (p.Lys526Glu)

ACCTTTCTGATCTGGTGTCAGA′]

3829
NM_000313.3(PROS1): c.773A > G
5627
PROS1
[′AACATGTGTGCTCAGCTTTGTGTCARTTAC

(p.Asn258Ser)

CCTGGAGGTTACACTTGCTAT′]

3830
NM_000313.3(PROS1): c.586A > G
5627
PROS1
[′AAATGGTTTTGTTATGCTTTCAAATRAGAA

(p.Lys196Glu)

AGATTGTAAAGGTAAGAGCAG′]

3831
NM_002834.3(PTPN11):
5781
PTPN11
[′GCCTGTTTCAGATTACATCAATGCARATAT

c.922A > G (p.Asn308Asp)

CATCATGGTAAGCTTTGCTTT′]

3832
NM_002834.3(PTPN11):
5781
PTPN11
[′CCTGTTTCAGATTACATCAATGCAAVTATC

c.923A > G (p.Asn308Ser)

ATCATGGTAAGCTTTGCTTTT′]

3833
NM_002834.3(PTPN11):
5781
PTPN11
[′CAAGAAAACAAAAACAAAAATAGATVTA

c.836A > G (p.Tyr279Cys)

AAAACATCCTGCCCTGTAAGTAT′]

3834
NM_002834.3(PTPN11):
5781
PTPN11
[′CACATCAAGATTCAGAACACTGGTGNTTA

c.182A > G (p.Asp61Gly)

CTATGACCTGTATGGAGGGGAG′]

3835
NM_002834.3(PTPN11):
5781
PTPN11
[′AAGATTCAGAACACTGGTGATTACTRTGA

c.188A > G (p.Tyr63Cys)

CCTGTATGGAGGGGAGAAATTT′]

3836
NM_002834.3(PTPN11):
5781
PTPN11
[′GGGGAGAAATTTGCCACTTTGGCTGNGTT

c.227A > G (p.Glu76Gly)

GGTCCAGTATTACATGGAACAT′]

3837
NM_002834.3(PTPN11):
5781
PTPN11
[′TTTGCCACTTTGGCTGAGTTGGTCCRGTAT

c.236A > G (p.Gln79Arg)

TACATGGAACATCACGGGCAA′]

3838
NM_002834.3(PTPN11):
5781
PTPN11
[′TCAGGGATGGTCCAGACAGAAGCACVGTA

c.1529A > G (p.Gln510Arg)

CCGATTTATCTATATGGCGGTC′]

3839
NM_002755.3(MAP2K1):
5604
MAP2K1
[′AACTCTCCGTACATCGTGGGCTTCTRTGGT

c.389A > G (p.Tyr130Cys)

GCGTTCTACAGCGATGGCGAG′]

3840
NM_006006.4(ZBTB16):
7704
ZBTB16
[′CCAGCGCTCCCGGGACTACTCGGCCRTGAT

c.1849A > G (p.Met617Val)

CAAGCACCTGAGAACGCACAA′]

3841
NM_000311.3(PRNP): c.385A > G
5621
PRNP
[′AGTGGTGGGGGGCCTTGGCGGCTACRTGC

(p.Met129Val)

TGGGAAGTGCCATGAGCAGGCC′]

3842
NM_000311.3(PRNP): c.650A > G
5621
PRNP
[′GTGGTTGAGCAGATGTGTATCACCCRGTAC

(p.Gln217Arg)

GAGAGGGAATCTCAGGCCTAT′]

3843
NM_000311.3(PRNP): c.547A > G
5621
PRNP
[′CTTTGTGCACGACTGCGTCAATATCRCAAT

(p.Thr183Ala)

CAAGCAGCACACGGTCACCAC′]

3844
NM_000311.3(PRNP): c.560A > G
5621
PRNP
[′TGCGTCAATATCACAATCAAGCAGCRCAC

(p.His187Arg)

GGTCACCACAACCACCAAGGGG′]

3845
NM_000371.3(TTR): c.401A > G
7276
TTR
[′ACCATTGCCGCCCTGCTGAGCCCCTRCTCC

(p.Tyr134Cys)

TATTCCACCACGGCTGTCGTC′]

3846
NM_000371.3(TTR): c.238A > G
7276
TTR
[′GTCTGGAGAGCTGCATGGGCTCACARCTG

(p.Thr80Ala)

AGGAGGAATTTGTAGAAGGGAT′]

3847
NM_000371.3(TTR): c.185A > G
7276
TTR
[′AGAAAGGCTGCTGATGACACCTGGGRGCC

(p.Glu62Gly)

ATTTGCCTCTGGGTAAGTTGCC′]

3848
NM_000371.3(TTR): c.205A > G
7276
TTR
[′CCAGACTTTCACACCTTATAGGAAARCCA

(p.Thr69Ala)

GTGAGTCTGGAGAGCTGCATGG′]

3849
NM_000371.3(TTR): c.379A > G
7276
TTR
[′CGACTCCGGCCCCCGCCGCTACACCRTTGC

(p.Ile127Val)

CGCCCTGCTGAGCCCCTACTC′]

3850
NM_000371.3(TTR): c.113A > G
7276
TTR
[′TGTCCTCTGATGGTCAAAGTTCTAGRTGCT

(p.Asp38Gly)

GTCCGAGGCAGTCCTGCCATC′]

3851
NM_000217.2(KCNA1): c.676A > G
3736
KCNA1
[′CACAGACCCCTTCTTCATCGTGGAARCGCT

(p.Thr226Ala)

GTGTATCATCTGGTTCTCCTT′]

3852
NM_000217.2(KCNA1): c.763A > G
3736
KCNA1
[′GACGGACTTCTTCAAAAACATCATGRACTT

(p.Asn255Asp)

CATAGACATTGTGGCCATCAT′]

3853
NM_002693.2(POLG): c.2864A > G
5428
POLG
[′AAAATCTTCAACTACGGCCGCATCTRTGGT

(p.Tyr955Cys)

GCTGGGCAGCCCTTTGCTGAG′]

3854
NM_002693.2(POLG): c.2591A > G
5428
POLG
[′GAGCCCACATGGCTCACCGCCAGCARTGC

(p.Asn864Ser)

CCGGGTATGTGACCTCTGTACC′]

3855
NM_000174.4(GP9): c.182A > G
2815
GP9
[′ACCCGCCACCTTCTGCTGGCCAACARCAGC

(p.Asn61Ser)

CTTCAGTCCGTGCCCCCGGGA′]

3856
NM_000174.4(GP9): c.110A > G
2815
GP9
[′CTGGAAACCATGGGGCTGTGGGTGGRCTG

(p.Asp37Gly)

CAGGGGCCACGGACTCACGGCC′]

3857
NM_006206.4(PDGFRA):
5156
PDGFRA
[′CCTGGTCATTTATAGAAACCGAGGTRTGA

c.1664A > G (p.Tyr555Cys)

AATTCGCTGGAGGGTCATTGAA′]

3858
NM_000301.3(PLG): c.112A > G
5340
PLG
[′GGGGGCTTCACTGTTCAGTGTCACTRAGAA

(p.Lys38Glu)

GCAGCTGGGAGCAGGAAGTAT′]

3859
NM_000293.2(PHKB):
5257
PHKB
[′GTTTCATGAGTTATCTCTCTCACCCRGGCG

c.306 − 2A > G

AATTGATGATGACAAGGGAAG′]

3860
NM_000175.3(GPI): c.1028A > G
2821
GPI
[′ACACACGCCATGCTGCCCTATGACCRGTAC

(p.Gln343Arg)

CTGCACCGCTTTGCTGCGTAC′]

3861
NM_002633.2(PGM1): c.343A > G
5236
PGM1
[′CAAAGCCATTGGTGGGATCATTCTGRCAG

(p.Thr115Ala)

CCAGTCACAACCCAGGGGGCCC′]

3862
NM_006218.2(PIK3CA):
5290
PIK3CA
[′TTCATGAAACAAATGAATGATGCACDTCA

c.3140A > G (p.His1047Arg)

TGGTGGCTGGACAACAAAAATG′]

3863
NM_006218.2(PIK3CA):
5290
PIK3CA
[′CGAGATCCTCTCTCTGAAATCACTGVGCAG

c.1634A > G (p.Glu545Gly)

GAGAAAGATTTTCTATGGAGT′]

3864
NM_000478.4(ALPL): c.1250A > G
249
ALPL
[′CCCTTCACTGCCATCCTGTATGGCARTGGG

(p.Asn417Ser)

CCTGGCTACAAGGTGGTGGGC′]

3865
NM_018849.2(ABCB4): c.523A > G
5244
ABCB4
[′AGAAATAAACAGGTATAAGATGTGARTTC

-
(p.Thr175Ala)

AGTCCTCAAATAAACCTACTAT′,

3867

TTCTATATGAAAGTGTGACATTAACRATGT

ACCTACTCTGTTAGCCGCGYA′,

′TTTCCTGTCGTAGAATAGCATGAAARAACT

TCTGCCTAATTTTCCTGATCT′]

3868
NM_001083116.1(PRF1):
5551
PRF1
[′CTGGCCCTGGAAGGGCTCACGGACARCGA

c.755A > G (p.Asn252Ser)

GGTGGAGGACTGCCTGACTGTC′]

3869
NM_198965.1(PTHLH): c.534A > G
5744
PTHLH
[′TTCCTTCTTTTTGCAGGAGGCATTGRAATT

(p.Ter178Trp)

TTCAGCAGAGACCTTCCAAGG′]

3870
NM_000316.2(PTH1R): c.668A > G
5745
PTH1R
[′CTGCACTGCACGCGCAACTACATCCRCATG

(p.His223Arg)

CACCTGTTCCTGTCCTTCATG′]

3871
NM_003122.4(SPINK1):
6690
SPINK1
[′TTCCATTTTTAGGCCAAATGTTACARTGAA

c.101A > G (p.Asn34Ser)

CTTAATGGATGCACCAAGATA′]

3872
NM_006194.3(PAX9): c.271A > G
5083
PAX9
[′CGTGGTGAAACACATCCGGACCTACRAGC

(p.Lys91Glu)

AGAGAGACCCCGGCATCTTCGC′]

3873
NM_013953.3(PAX8): c.160A > G
−1
—
[′CGACATCTCTCGCCAGCTCCGCGTCRGCCA

(p.Ser54Gly)

TGGCTGCGTCAGCAAGATCCT′]

3874
NM_005188.3(CBL): c.1144A > G
867
CBL
[′GATGGGCTCCACATTCCAACTATGTRAAAT

(p.Lys382Glu)

ATGTGCTGAAAATGATAAGGA′]

3875
NM_000222.2(KIT): c.2459A > G
3815
KIT
[′GGTCTAGCCAGAGACATCAAGAATGRTTC

(p.Asp820Gly)

TAATTATGTGGTTAAAGGAAAC′]

3876
NM_000222.2(KIT): c.2386A > G
3815
KIT
[′GTGTATTCACAGAGACTTGGCAGCCRGAA

(p.Arg796Gly)

ATATCCTCCTTACTCATGGTCG′]

3877
NM_000222.2(KIT): c.1924A > G
3815
KIT
[′ACGGGAAGCCCTCATGTCTGAACTCRAAG

(p.Lys642Glu)

TCCTGAGTTACCTTGGTAATCA′]

3878
NM_001005862.2(ERBB2):
2064
ERBB2
[′CGGAACGTGCTGGTCAAGAGTCCCARCCA

c.2480A > G (p.Asn827Ser)

TGTCAAAATTACAGACTTCGGG′]

3879
NM_001127500.1(MET):
4233
MET
[′GATTTTGGTCTTGCCAGAGACATGTRTGAT

c.3743A > G (p.Tyr1248Cys)

AAAGAATACTATAGTGTACAC′]

3880
NM_001127500.1(MET):
4233
MET
[′ACAGGGCATTTTGGTTGTGTATATCVTGGG

c.3335A > G (p.His1112Arg)

ACTTTGTTGGACAATGATGGC′]

3881
NM_001127500.1(MET):
4233
MET
[′AGTGTACACAACAAAACAGGTGCAARGCT

c.3785A > G (p.Lys1262Arg)

GCCAGTGAAGTGGATGGCTTTG′]

3882
NM_002524.4(NRAS): c.182A > G
4893
NRAS
[′TTGGACATACTGGATACAGCTGGACNAGA

(p.Gln61Arg)

AGAGTACAGTGCCATGAGAGAC′]

3883
NM_004333.4(BRAF): c.1801A > G
673
BRAF
[′AGGTGATTTTGGTCTAGCTACAGTGVAATC

(p.Lys601Glu)

TCGATGGAGTGGGTCCCATCA′]

3884
NM_004333.4(BRAF): c.1781A > G
673
BRAF
[′GAAGACCTCACAGTAAAAATAGGTGDTTT

(p.Asp594Gly)

TGGTCTAGCTACAGTGAAATCT′]

3885
NM_004333.4(BRAF): c.770A > G
673
BRAF
[′GACTTTTGTCGAAAGCTGCTTTTCCRGGGT

(p.Gln257Arg)

TTCCGCTGTCAAACATGTGGT′]

3886
NM_004333.4(BRAF): c.1495A > G
673
BRAF
[′TACACCTCAGCAGTTACAAGCCTTCRAAA

(p.Lys499Glu)

ATGAAGTAGGAGTACTCAGGTG′]

3887
NM_004333.4(BRAF): c.1502A > G
673
BRAF
[′CAGCAGTTACAAGCCTTCAAAAATGNAGT

(p.Glu501Gly)

AGGAGTACTCAGGTGAGCTTGT′]

3888
NM_004333.4(BRAF): c.1741A > G
673
BRAF
[′CATCCACAGAGACCTCAAGAGTAATVGTA

(p.Asn581Asp)

TCCTTCCTGAAATTTGTCTGCG′]

3889
NM_000270.3(PNP): c.383A > G
4860
PNP
[′CTGAACCCCAAGTTTGAGGTTGGAGRTATC

(p.Asp128Gly)

ATGCTGATCCGTGACCATATC′]

3890
NM_000270.3(PNP): c.575A > G
4860
PNP
[′CAACGTGAGCTACAGGAAGGCACCTRTGT

(p.Tyr192Cys)

GATGGTGGCAGGCCCCAGCTTT′]

3891
NM_000258.2(MYL3): c.445A > G
4634
MYL3
[′CGACAAGGAGGGCAATGGCACTGTCRTGG

(p.Met149Val)

GTGCTGAGCTTCGCCACGTGCT′]

3892
NM_000257.3(MYH7): c.2333A > G
4625
MYH7
[′CTGGGGCTGCTGGAGGAAATGAGGGRCGA

(p.Asp778Gly)

GAGGCTGAGCCGCATCATCACG′]

3893
NM_000257.3(MYH7): c.2717A > G
4625
MYH7
[′CTGGCAGATGCTGAGGAGCGCTGTGRTCA

(p.Asp906Gly)

GCTGATCAAAAACAAGATTCAG′]

3894
NM_002470.3(MYH3): c.1385A > G
4621
MYH3
[′AGACAACACTTCATTGGTGTTTTGGRCATT

(p.Asp462Gly)

GCAGGCTTTGAAATCTTTGAG′]

3895
NM_000530.6(MPZ): c.286A > G
4359
MPZ
[′CTACATTGACGAGGTGGGGACCTTCRAAG

(p.Lys96Glu)

AGCGCATCCAGTGGGTAGGGGA′]

3896
NM_000530.6(MPZ): c.242A > G
4359
MPZ
[′TCCCCTCATTCCTCATAGATCTTCCRCTAT

(p.His81Arg)

GCCAAGGGACAACCCTACATT′]

3897
NG_012123.1: g.2493A > G
6347
CCL2
[′GAAAAGAAAGTCTTCTGGAAAGTGAYAGC

TGTCTGCCTCCCACTTCTGCTC′]

3898
RMRP: n.71A > G
6023
RMRP
[′TGTTCCTCCCCTTTCCGCCTAGGGGRAAGT

CCCCGGACCTCGGGCAGAGAG′]

3899
NM_005006.6(NDUFS1):
4719
NDUFS1
[′TTTCTCAGAAAGACAGAATCCATTGRTGTA

c.755A > G (p.Asp252Gly)

ATGGATGCGGTTGGAAGTAAT′]

3900
NM_005912.2(MC4R): c.508A > G
4160
MC4R
[′GACAGTTAAGCGGGTTGGGATCATCRTAA

(p.Ile170Val)

GTTGTATCTGGGCAGCTTGCAC′]

3901
NM_005912.2(MC4R): c.821A > G
4160
MC4R
[′ATATTCTACATCTCTTGTCCTCAGARTCCA

(p.Asn274Ser)

TATTGTGTGTGCTTCATGTCT′]

3902
NM_005912.2(MC4R): c.289A > G
4160
MC4R
[′GGCTGATATGCTGGTGAGCGTTTCARATGG

(p.Asn97Asp)

ATCAGAAACCATTGTCATCAC′]

3903
NM_005912.2(MC4R): c.185A > G
4160
MC4R
[′CTGGGTGTCATCAGCTTGTTGGAGARTATC

(p.Asn62Ser)

TTAGTGATTGTGGCAATAGCC′]

3904
NM_000900.3(MGP):
4256
MGP
[′AAGATTCCATGCTTTCATGTGATTCHGAAA

c.62 − 2A > G

TTAAAAAAAAAAGATTCATTA′]

3905
NM_012064.3(MIP): c.401A > G
4284
MIP
[′AGCGTGGGCCAGGCAACCACAGTGGRGAT

(p.Glu134Gly)

CTTCCTGACGCTCCAGTTCGTG′]

3906
NM_000233.3(LHCGR):
−1
—
[′AAAATGGCAATCCTCATCTTCACCGRTTTC

c.1733A > G (p.Asp578Gly)

ACCTGCATGGCACCTATCTCT′]

3907
NM_000233.3(LHCGR)
−1
—
[′CCAGAATTAATGGCTACCAATAAAGRTAC

c.1691A > G (p.Asp564Gly)

AAAGATTGCTAAGAAAATGGCA′]

3908
NM_000894.2(LHB): c.221A > G
3972
LHB
[′CAGGCGGTCCTGCCGCCCCTGCCTCRGGTG

(p.Gln74Arg)

GTGTGCACCTACCGTGATGTG′]

3909
NM_000238.3(KCNH2):
3757
KCNH2
[′CATGTTCATTGTGGACATCCTCATCRACTT

c.1408A > G (p.Asn470Asp)

CCGCACCACCTACGTCAATGC′]

3910
NM_001754.4(RUNX1): c.328A > G
861
RUNX1
[′GCTGCCTACGCACTGGCGCTGCAACRAGA

(p.Lys110Glu)

CCCTGCCCATCGCTTTCAAGGT′]

3911
NM_170707.3(LMNA): c.608A > G
4000
LMNA
[′AACAGGCTGCAGACCATGAAGGAGGDACT

(p.Glu203Gly)

GGACTTCCAGAAGAACATCTAC′]

3912
NM_000421.3(KRT10):
−1
—
[′TGAATACCAACAACTCCTGGATATTDAGA

c.1315A > G (p.Lys439Glu)

TCCGACTGGAGAATGAAATTCA′]

3913
NM_000421.3(KRT10):
−1
—
[′CCGCCGCGTCCGCCGCCTCCGGAACYAAA

c. 1374 − 2A > G

CGGGGTGAGGTCACATTCGGTT′]

3914
NM_000422.2(KRT17): c.274A > G
3872
KRT17
[′TGAGAAGGCCACCATGCAGAACCTCVATG

(p.Asn92Asp)

ACCGCCTGGCCTCCTACCTGGA′]

3915
NM_000422.2(KRT17): c.275A > G
3872
KRT17
[′GAGAAGGCCACCATGCAGAACCTCARTGA

(p.Asn92Ser)

CCGCCTGGCCTCCTACCTGGAC′]

3916
NM_005557.3(KRT16): c.374A > G
3868
KRT16
[′GAGAAGGTGACCATGCAGAACCTCARTGA

(p.Asn125Ser)

CCGCCTGGCCTCCTACCTGGAC′]

3917
NM_000526.4(KRT14): c.368A > G
3861
KRT14
[′GAGAAGGTGACCATGCAGAACCTCARTGA

(p.Asn123Ser)

CCGCCTGGCCTCCTACCTGGAC′]

3918
NM_000424.3(KRT5): c.1424A > G
3852
KRT5
[′ATCGCCACTTACCGCAAGCTGCTGGRGGG

(p.Glu475Gly)

CGAGGAATGCAGGTGAGTAGAC′]

3919
NM_000418.3(IL4R): c.223A > G
3566
IL4R
[′CTGTGTCTGCAGAGCCCACACGTGTNTCCC

(p.Ile75Val)

TGAGAACAACGGAGGCGCGGG′]

3920
NM_001079817.1(INSR):
3643
INSR
[′CCAGGAGAGAAACGACATTGCCCTGRAGA

c.1459A > G (p.Lys487Glu)

CCAATGGGGACCAGGCATCCTG′]

3921
NM_000208.2(INSR): c.707A > G
3643
INSR
[′TGCACCGCCGAAGGCCTCTGTTGCCRCAGC

(p.His236Arg)

GAGTGCCTGGGCAACTGTTCT′]

3922
NM_000208.2(INSR): c.1466A > G
3643
INSR
[′AGAAACGACATTGCCCTGAAGACCARTGG

(p.Asn489Ser)

GGACCAGGCATCCTGTAAGTCA′]

3923
NM_000208.2(INSR):
3643
INSR
[′CTTCTAGCTCAGCTGCCAGATTGTCYAAGG

c.1124 − 2A > G

AAAGGAGAGAATATCCAGTGG′]

3924
NM_000208.2(INSR): c.1372A > G
3643
INSR
[′TCAGGGGAAACTCTTCTTCCACTATRACCC

(p.Asn458Asp)

CAAACTCTGCTTGTCAGAAAT′]

3925
NM_000454.4(SOD1): c.131A > G
6647
SOD1
[′ATTAAAGGACTGACTGAAGGCCTGCRTGG

(p.His44Arg)

ATTCCATGTTCATGAGTTTGGA′]

3926
NM_000454.4(SOD1): c.302A > G
6647
SOD1
[′GATGGTGTGGCCGATGTGTCTATTGRAGAT

(p.Glu101Gly)

TCTGTGATCTCACTCTCAGGA′]

3927
NM_000454.4(SOD1): c.140A > G
6647
SOD1
[′CTGACTGAAGGCCTGCATGGATTCCRTGTT

(p.His47Arg)

CATGAGTTTGGAGATAATACA′]

3928
NM_000454.4(SOD1): c.242A > G
6647
SOD1
[′ATCTGATGCTTTTTCATTATTAGGCRTGTT

(p.His81Arg)

GGAGACTTGGGCAATGTGACT′]

3929
NM_000183.2(HADHB): c.788A > G
3032
HADHB
[′GCACAGGATGAAGGACTCCTTTCTGRTGTG

(p.Asp263Gly)

GTACCCTTCAAAGTACCAGGT′]

3930
NM_000523.3(HOXD13):
3239
HOXD13
[′GAGAGACAAGTGACCATTTGGTTTCRGAA

c.974A > G (p.Gln325Arg)

CCGAAGAGTGAAGGACAAGAAA′]

3931
NM_000545.6(HNF1A): c.365A > G
6927
HNF1A
[′CGTGTGGCGAAGATGGTCAAGTCCTRCCT

(p.Tyr122Cys)

GCAGCAGCACAACATCCCACAG′]

3932
NM_000519.3(HBD): c.−81A > G
3045
HBD
[′CTGGAGCAGGGAGGACAGGACCAGCRTAA

AAGGCAGGGCAGAGTCGACTGT′]

3933
NM_000518.4(HBB): c.199A > G
3043
HBB
[′CCCTAAGGTGAAGGCTCATGGCAAGRAAG

(p.Lys67Glu)

TGCTCGGTGCCTTTAGTGATGG′]

3934
NM_000518.4(HBB): c.59A > G
3043
HBB
[′GTTACTGCCCTGTGGGGCAAGGTGARCGT

(p.Asn20Ser)

GGATGAAGTTGGTGGTGAGGCC′]

3935
NM_000518.4(HBB): c.−81A > G
3043
HBB
[′GGGAGGGCAGGAGCCAGGGCTGGGCVTA

AAAGTCAGGGCAGAGCCATCTAT′]

3936
NM_000518.4(HBB):
3043
HBB
[′GAGGGCAGGAGCCAGGGCTGGGCATRAAA

c.−50 − 29A > G

GTCAGGGCAGAGCCATCTATTG′]

3937
NM_000518.4(HBB): c.−78A > G
3043
HBB
[′AGGGCAGGAGCCAGGGCTGGGCATAVAA

GTCAGGGCAGAGCCATCTATTGC′]

3938
NM_000518.4(HBB): c.*113A > G
3043
HBB
[′TGAGCATCTGGATTCTGCCTAATAARAAAC

ATTTATTTTCATTGCAATGAT′]

3939
NM_000518.4(HBB): c.*112A > G
3043
HBB
[′TTGAGCATCTGGATTCTGCCTAATADAAAA

CATTTATTTTCATTGCAATGA′]

3940
NM_000518.4(HBB): c.*111A > G
3043
HBB
[′CTTGAGCATCTGGATTCTGCCTAATRAAAA

ACATTTATTTTCATTGCAATG′]

3941
NM_000518.4(HBB): c.80A > G
3043
HBB
[′GTGAACGTGGATGAAGTTGGTGGTGNGGC

(p.Glu27Gly)

CCTGGGCAGGTTGGTATCAAGG′]

3942
NM_000518.4(HBB): c.247A > G
3043
HBB
[′TGGCCTGGCTCACCTGGACAACCTCVAGG

(p.Lys83Glu)

GCACCTTTGCCACACTGAGTGA′]

3943
NM_000517.4(HBA2): c.1A > G
3040
HBA2
[′CCCACAGACTCAGAGAGAACCCACCRTGG

(p.Met1Val)

TGCTGTCTCCTGCCGACAAGAC′]

3944
NM_000517.4(HBA2): c.*92A > G
3040
HBA2
[′CACCGGCCCTTCCTGGTCTTTGAATRAAGT

CTGAGTGGGCAGCAGCCTGTG′]

3945
NM_000517.4(HBA2):
3040
HBA2
[′CACCCCTCACTCTGCTTCTCCCCGCRGGAT

c.96 − 2A > G

GTTCCTGTCCTTCCCCACCAC′]

3946
NM_006121.3(KRT1): c.1445A > G
3848
KRT1
[′GCCCTGGATCTGGAGATTGCCACCTRCAG

(p.Tyr482Cys)

GACCCTCCTGGAGGGAGAAGAA′]

3947
NM_001077488.3(GNAS): c.1A > G
2778
GNAS
[′GCGCCCCGCCGCCGCCGCCGCCGCCRTGG

(p.Met1Val)

GCTGCCTCGGGAACAGTAAGAC′]

3948
NM_000516.5(GNAS): c.680A > G
2778
GNAS
[′ACCAGCATGTTTGACGTGGGTGGCCDGCG

(p.Gln227Arg)

CGATGAACGCCGCAAGTGGATC′]

3949
NM_000515.4(GH1): c.413A > G
2688
GH1
[′GGCGCCTCTGACAGCAACGTCTATGRCCTC

(p.Asp138Gly)

CTAAAGGACCTAGAGGAAGGC′]

3950
NM_000823.3(GHRHR): c.985A > G
2692
GHRHR
[′TTGTCTTTCCTGCAGGCGTCTCTCCRAGTC

(p.Lys329Glu)

GACACTTTTCCTGATCCCACT′]

3951
NM_002890.2(RASA1):
5921
RASA1
[′GACCAATGAAAATATTCAGCGATTTRAAA

c.1198A > G (p.Lys400Glu)

TATGTCCAACGCCAAACAATCA′]

3952
NM_002890.2(RASA1):
5921
RASA1
[′CAATGAAAATATTCAGCGATTTAAARTAT

c.1201A > G (p.Ile401Val)

GTCCAACGCCAAACAATCAGTT′]

3953
NM_000406.2(GNRHR): c.317A > G
2798
GNRHR
[′GATGGGATGTGGAACATTACAGTCCRATG

(p.Gln106Arg)

GTATGCTGGAGAGTTACTCTGC′]

3954
NM_000406.2(GNRHR): c.851A > G
2798
GNRHR
[′TTTACTGTCTGCTGGACTCCCTACTRTGTC

(p.Tyr284Cys)

CTAGGAATTTGGTATTGGTTT′]

3955
NM_000407.4(GP1BB): c.338A > G
−1
—
[′GCCGGCCGCCCCGAGCGTGCGCCCTDCCG

(p.Tyr113Cys)

CGACCTGCGTTGCGTGGCGCCC′]

3956
NM_021957.3(GYS2): c.116A > G
2998
GYS2
[′TTTGAAGTTGCTTGGGAAGTGACCARTAA

(p.Asn39Ser)

AGGTTTGTACTGCTCCTGAAGG′]

3957
NM_001146040.1(GLRA1):
2741
GLRA1
[′CCTCCACCCCCACTCTAGGTGTCCTVTGTG

c.920A > G (p.Tyr307Cys)

AAAGCCATTGACATTTGGATG′]

3958
NM_001146040.1(GLRA1):
2741
GLRA1
[′CTCCGGCTCTCGAGCATCTCTGCCCRAGGT

c.910A > G (p.Lys304Glu)

AAGTCCCATTGCCCAAGAGCA′]

3959
NM_000171.3(GLRA1): c.523A > G
2741
GLRA1
[′CCCCATGGACTTGAAGAATTTCCCCRTGGA

(p.Met175Val)

TGTCCAGACATGTATCATGCA′]

3960
NM_000162.3(GCK): c.641A > G
2645
GCK
[′ACGGTGGCCACGATGATCTCCTGCTRCTAC

(p.Tyr214Cys)

GAAGACCATCAGTGCGAGGTC′]

3961
NM_000145.3(FSHR): c.1345A > G
2492
FSHR
[′AGGCTGTGATGCTGCTGGCTTTTTCRCTGT

(p.Thr449Ala)

CTTTGCCAGTGAGCTGTCAGT′]

3962
NM_182925.4(FLT4): c.3104A > G
2324
FLT4
[′CGCCTCCCCGCACCCCAGTGCATCCRCAGA

(p.His 1035Arg)

GACCTGGCTGCTCGGAACATT′]

3963
NM_023110.2(FGFR1):
2260
FGFR1
[′CCGGCAGTGATGACCTCGCCCCTGTRCCTG

c.1121A > G (p.Tyr374Cys)

GAGATCATCATCTATTGCACA′]

3964
NM_006894.5(FMO3): c.182A > G
2328
FMO3
[′AGCATTTACAAATCAGTCTTTTCCARCTCT

(p.Asn61Ser)

TCCAAAGAGATGATGTGTTTC′]

3965
NM_001002294.2(FMO3):
2328
FMO3
[′AAGCCTAACGTGAAGGAATTCACAGRGAC

c.923A > G (p.Glu308Gly)

CTCGGCCATTTTTGAGGATGGG′]

3966
NM_212482.1(FN1): c.2918A > G
2335
FN1
[′ACCGGGCTGTCCCCTGGGGTCACCTRTTAC

(p.Tyr973Cys)

TTCAAAGTCTTTGCAGTGAGC′]

3967
NM_000142.4(FGFR3):
2261
FGFR3
[′CGTGCACAACCTCGACTACTACAAGVAGA

c.1948A > G (p.Lys650Glu)

CAACCAACGTGAGCCCGGCCCT′]

3968
NM_000142.4(FGFR3): c.1118A > G
2261
FGFR3
[′GAGGCTGACGAGGCGGGCAGTGTGTRTGC

(p.Tyr373Cys)

AGGCATCCTCAGCTACGGGGTG′]

3969
NM_000142.4(FGFR3): c.1612A > G
2261
FGFR3
[′GTGCAGGCGCCCAGCAGGTTGATGAYGTT

(p.Ile538Val)

TTTGTGTTTCCCGATCATCTTC′]

3970
NM_000142.4(FGFR3): c.1619A > G
2261
FGFR3
[′GCCCTGCGTGCAGGCGCCCAGCAGGBTGA

(p.Asn540Ser)

TGATGTTTTTGTGTTTCCCGAT′]

3971
NM_000142.4(FGFR3): c.833A > G
2261
FGFR3
[′GACGTGGAGTTCCACTGCAAGGTGTRCAG

(p.Tyr278Cys)

TGACGCACAGCCCCACATCCAG′]

3972
NM_000138.4(FBN1): c.6431A > G
2200
FBN1
[′GTCTGTAAACATGGACAGTGCATCARTAC

(p.Asn2144Ser)

AGATGGTTCCTATCGCTGCGAG′]

3973
NM_000138.4(FBN1): c.3128A > G
2200
FBN1
[′ATACCCAGCCTCTGCACCCACGGCARGTG

(p.Lys1043Arg)

CAGAAACACCATTGGCAGCTTT′]

3974
NM_000138.4(FBN1): c.2261A > G
2200
FBN1
[′TATAAATGTATATGCAATTCAGGATRTGAA

(p.Tyr754Cys)

GTGGATTCAACTGGGAAAAAC′]

3975
NM_000146.3(FTL): c.−160A > G
2512
FTL
[′CCGCGGGTCTGTCTCTTGCTTCAACRGTGT

TTGGACGGAACAGATCCGGGG′]

3976
NM_000043.4(FAS): c.695A > G
355
FAS
[′TTTTCAGATGTTGACTTGAGTAAATRTATC

(p.Tyr232Cys)

ACCACTATTGCTGGAGTCATG′]

3977
NM_000043.4(FAS): c.763A > G
355
FAS
[′AGGCTTTGTTCGAAAGAATGGTGTCRATG

(p.Asn255Asp)

AAGCCAAAATAGATGAGATCAA′]

3978
NM_000043.4(FAS): c.353A > G
355
FAS
[′TTTCTAGGCTTAGAAGTGGAAATAARCTGC

(p.Asn118Ser)

ACCCGGACCCAGAATACCAAG′]

3979
NM_000129.3(F13A1): c.851A > G
2162
F13A1
[′CTCGTTGGATCCTGGGACAATATCTRTGCC

(p.Tyr284Cys)

TATGGCGTCCCCCCATCGGCC′]

3980
NM_000121.3(EPOR): c.1460A > G
2057
EPOR
[′GGCTTATCCGATGGCCCCTACTCCARCCCT

(p.Asn487Ser)

TATGAGAACAGCCTTATCCCA′]

3981
NM_207034.2(EDN3): c.335A > G
1908
EDN3
[′GACAAGGAGTGTGTCTACTATTGCCRCCTG

(p.His112Arg)

GACATCATTTGGATCAACACT′]

3982
NM_001257988.1(TYMP):
1890
TYMP
[′CAGAGCGGACAGCCCCTCCACGAGTYTCT

c.665A > G (p.Lys222Arg)

TACTGAGAATGGAGGCTTTGGG′]

3983
NM_003286.2(TOP1): c.1598A > G
−1
—
[′GTAGAGTTTGACTTCCTCGGGAAGGRCTCC

(p.Asp533Gly)

ATCAGATACTATAACAAGGTC′]

3984
NM_001943.3(DSG2): c.797A > G
1829
DSG2
[′GTTCAGATTCGTATTTTGGATGTCARTGAC

(p.Asn266Ser)

AATATACCTGTAGTAGAAAAT′]

3985
NM_001943.3(DSG2):
1829
DSG2
[′TCTGTGTTCAATTTTGTGTCTGTACRGTGG

c.1880 − 2A > G

TACCACTTTTACTGCTGATGT′]

3986
NM_024422.4(DSC2):
1824
DSC2
[′TTTCTCCTTATTTTACTCTCTTCACRGATAA

c.631 − 2A > G

TTGCCTTTGCAACAACTCCA′]

3987
NG_012088.1: g.2209A > G
3586
IL10
[′CCAGGATGGTCTCGATCTCCTGACCYTATG

ATCCGCCCGCCTTGGCCTCCC′]

3988
NM_000498.3(CYP11B2):
−1
—
[′GAGGCCTGGCACGTCCCCCCTCCTCRCTTT

c.1492A > G (p.Thr498Ala)

CAGAGCGATTAACTAGTCTTG′]

3989
NM_000941.2(POR): c.1733A > G
5447
POR
[′CGCCGCTCGGATGAGGACTACCTGTRCCG

(p.Tyr578Cys)

GGAGGAGCTGGCGCAGTTCCAC′]

3990
NM_000941.2(POR): c.15A > G
5447
POR
[′CTAACAGTTTCATGATCAACATGGGRGACT

(p.Gly5=)

CCCACGTGGACACCAGCTCCA′]

3991
NM_001885.2(CRYAB): c.358A > G
1410
CRYAB
[′TGGTTTCATCTCCAGGGAGTTCCACRGGAA

(p.Arg120Gly)

ATACCGGATCCCAGCTGATGT′]

3992
NM_021954.3(GJA3): c.188A > G
2700
GJA3
[′AACACCCAGCAGCCGGGCTGCGAGARCGT

(p.Asn63Ser)

CTGCTACGACAGGGCCTTCCCC′]

3993
NM_004004.5(GJB2): c.218A > G
2706
GJB2
[′TACGATCACTACTTCCCCATCTCCCRCATC

(p.His73Arg)

CGGCTATGGGCCCTGCAGCTG′]

3994
NM_001735.2(C5): c.1115A > G
727
C5
[′CGTCTACCCCCTCACCCAATCTACCYTGAT

(p.Lys372Arg)

GGGATATGGAATCCCAGGCTT′]

3995
NM_001848.2(COL6A1):
1291
COL6A1
[′CTCAAAAGCAGCGTGGACGCGGTCARGTA

c.362A > G (p.Lys121Arg)

CTTTGGGAAGGGCACCTACACC′]

3996
NM_000093.4(COL5A1):
1289
COL5A1
[′TTTTCATGAGCGTCTCTTCTTTTCCRGGGTG

c.655 − 2A > G

ACATCCAGCAGCTGCTCTTT′]

3997
NM_000089.3(COL1A2):
1278
COL1A2
[′TATAATTTTTTTTTTTTACTTCTCTRGAACT

c.226 − 2A > G

TTGCTGCTCAGTATGATGGA′]

3998
NM_000089.3(COL1A2):
1278
COL1A2
[′GAGTGGGTACATTCTGAAAAGTAATRTAA

c.70 + 717A > G

GTGTCTCAATTCACTTTCTAGT′]

3999
NM_001844.4(COL2A1):
1280
COL2A1
[′ACGGAAGGCTCCCAGAACATCACCTRCCA

c.4172A > G (p.Tyr1391Cys)

CTGCAAGAACAGCATTGCCTAT′]

4000
NM_001844.4(COL2A1):
1280
COL2A1
[′CGGTCTGCCTGGGCAACGTGGTGAGRGAG

c.2974A > G (p.Arg992Gly)

GATTCCCTGGCTTGCCTGGCCC′]

4001
NM_000493.3(COL10A1):
−1
—
[′TTTACTTGTCAGATACCAGGAATATRCTAT

c.1790A > G (p.Tyr597Cys)

TTTTCATACCACGTGCATGTG′]

4002
NM_004385.4(VCAN):
1462
VCAN
[′GTATTGTGAAAACTCTGTTTTTTTCDGGTC

c.4004 − 2A > G

GAATGAGTGATTTGAGTGTAA′]

4003
NM_020549.4(CHAT): c.1444A > G
1103
CHAT
[′CGTCAGCGAGCTCCCCGCCCCCCGGVGGC

(p.Arg482Gly)

TGCGGTGGAAATGCTCCCCGGA′]

4004
NM_000078.2(CETP): c.1376A > G
1071
CETP
[′AACAGCAAAGGCGTGAGCCTCTTCGRCAT

(p.Asp459Gly)

CATCAACCCTGAGATTATCACT′]

4005
NM_000083.2(CLCN1):
1180
CLCN1
[′GTGATTTGCTTCGAATTAACGGGTCDGATT

c.1655A > G (p.Gln552Arg)

GCTCACATCCTGCCCATGATG′]

4006
NM_000083.2(CLCN1): c.382A > G
1180
CLCN1
[′CTTTCTGGTGCTTCTGGGACTGCTGRTGGC

(p.Met128Val)

TCTGGTCAGCTGGAGCATGGA′]

4007
NM_199440.1(HSPD1): c.86A > G
3329
HSPD1
[′CATCTCACTCGGGCTTATGCCAAAGRTGTA

(p.Asp29Gly)

AAATTTGGTGCAGATGCCCGA′]

4008
NM_001904.3(CTNNB1): c.95A > G
1499
CTNNB1
[′CACTGGCAGCAACAGTCTTACCTGGNCTCT

(p.Asp32Gly)

GGAATCCATTCTGGTGCCACT′]

4009
NM_001904.3(CTNNB1):
1499
CTNNB1
[′CTCTGGAATCCATTCTGGTGCCACTNCCAC

c.121A > G (p.Thr41Ala)

AGCTCCTTCTCTGAGTGGTAA′]

4010
NM_007294.3(BRCA1): c.211A > G
672
BRCA1
[′TTTATGTAAGAATGATATAACCAAARGGT

(p.Arg71Gly)

ATATAATTTGGTAATGATGCTA′]

4011
NM_001202.3(BMP4): c.278A > G
652
BMP4
[′GATCTTTACCGGCTTCAGTCTGGGGRGGAG

(p.Glu93Gly)

GAGGAAGAGCAGATCCACAGC′]

4012
NM_000342.3(SLC4A1):
6521
SLC4A1
[′CACCACATCACACCCGGGTACCCACRAGG

c.166A > G (p.Lys56Glu)

TGAGGACCCCAGCCTCCTCCGT′]

4013
NM_000342.3(SLC4A1):
6521
SLC4A1
[′GAAGACCTGGCGCATGCACTTATTCRCGG

c.2509A > G (p.Thr837Ala)

GCATCCAGATCATCTGCCTGGC′]

4014
NM_001681.3(ATP2A2):
488
ATP2A2
[′TTCATCCGCTACCTCATCTCGTCCARCGTC

c.2300A > G (p.Asn767Ser)

GGGGAAGTTGTCTGGTAGGTC′]

4015
NM_000486.5(AQP2): c.203A > G
359
AQP2
[′GGCCACATAAGCGGGGCCCACATCAVCCC

(p.Asn68Ser)

TGCCGTGACTGTGGCCTGCCTG′]

4016
NM_000041.3(APOE):
348
APOE
[′GACACCCTCCCGCCCTCTCGGCCGCRGGGC

c.237 − 2A > G

GCTGATGGACGAGACCATGAA′]

4017
NM_000041.3(APOE): c.490A > G
348
APOE
[′CGCCTCCCACCTGCGCAAGCTGCGTVAGC

(p.Lys164Glu)

GGCTCCTCCGCGATGCCGATGA′]

4018
NM_000041.3(APOE): c.178A > G
348
APOE
[′TTGGGATTACCTGCGCTGGGTGCAGRCACT

(p.Thr60Ala)

GTCTGAGCAGGTGCAGGAGGA′]

4019
NM_000040.1(APOC3): c.280A > G
345
APOC3
[′GGATTTGGACCCTGAGGTCAGACCARCTTC

(p.Thr94Ala)

AGCCGTGGCTGCCTGAGACCT′]

4020
NM_000040.1(APOC3): c.232A > G
345
APOC3
[′CCTGAAAGACTACTGGAGCACCGTTRAGG

(p.Lys78Glu)

ACAAGTTCTCTGAGTTCTGGGA′]

4021
NM_001042425.1(TFAP2A):
7020
TFAP2A
[′GTCGCTGCTGGGCGGAGTGCTCCGGVGGT

c.751A > G (p.Arg251Gly)

GAGGCCCGGCACGGCCCCGCCC′]

4022
NM_000488.3(SERPINC1):
462
SERPINC1
[′TGCAGAGCAATCCAGAGCGGCCATCRACA

c.655A > G (p.Asn219Asp)

AATGGGTGTCCAATAAGACCGA′]

4023
NM_001085.4(SERPINA3):
12
SERPINA3
[′TACAGACACCCAGAACATCTTCTTCRTGAG

c.1240A > G (p.Met414Val)

CAAAGTCACCAATCCCAAGCA′]

4024
NM_001148.4(ANK2): c.4373A > G
287
ANK2
[′TGCATGGCATCTTGGGGCGGAAAGGRATC

(p.Glu1458Gly)

AGAGTCAGATCAAGAACAGGAG′]

4025
NM_001145.4(ANG): c.121A > G
−1
—
[′CTTCCTGACCCAGCACTATGATGCCRAACC

(p.Lys41Glu)

ACAGGGCCGGGATGACAGATA′]

4026
NM_001145.4(ANG): c.208A > G
−1
—
[′ACCCTGCAAAGACATCAACACATTTRTTCA

(p.Ile70Val)

TGGCAACAAGCGCAGCATCAA′]

4027
NM_000484.3(APP): c.2146A > G
351
APP
[′GGGCGGTGTTGTCATAGCGACAGTGRTCG

(p.Ile716Val)

TCATCACCTTGGTGATGCTGAA′]

4028
NM_000484.3(APP): c.2078A > G
351
APP
[′TTTGTTTTCAAGGTGTTCTTTGCAGRAGAT

(p.Glu693Gly)

GTGGGTTCAAACAAAGGTGCA′]

4029
NM_000484.3(APP): c.2140A > G
351
APP
[′CATGGTGGGCGGTGTTGTCATAGCGRCAG

(p.Thr714Ala)

TGATCGTCATCACCTTGGTGAT′]

4030
NM_000021.3(PSEN1): c.488A > G
5663
PSEN1
[′AAATGCTTTCTTTTCTAGGTCATCCRTGCC

(p.His163Arg)

TGGCTTATTATATCATCTCTA′]

4031
NM_000021.3(PSEN1): c.415A > G
5663
PSEN1
[′GCACTCAATTCTGAATGCTGCCATCRTGAT

(p.Met139Val)

CAGTGTCATTGTTGTCATGAC′]

4032
NM_000021.3(PSEN1): c.436A > G
5663
PSEN1
[′CATCATGATCAGTGTCATTGTTGTCNTGAC

(p.Met146Val)

TATCCTCCTGGTGGTTCTGTA′]

4033
NM_000021.3(PSEN1): c.839A > G
5663
PSEN1
[′GTTGAAACAGCTCAGGAGAGAAATGVAAC

(p.Glu280Gly)

GCTTTTTCCAGCTCTCATTTAC′]

4034
NM_000021.3(PSEN1): c.998A > G
5663
PSEN1
[′CAAGACACTGTTGCAGAGAATGATGRTGG

(p.Asp333Gly)

CGGGTTCAGTGAGGAATGGGAA′]

4035
NM_000034.3(ALDOA): c.386A > G
226
ALDOA
[′CCCCTTCCTCTTCTCTTAGGGTTGGRTGGG

(p.Asp129Gly)

CTGTCTGAGCGCTGTGCCCAG′]

4036
NM_000477.5(ALB):
213
ALB
[′CATTTTGATTGGCGATTTTCTTTTTDGGGC

c.714 − 2A > G

AGTAGCTCGCCTGAGCCAGAG′]

4037
NM_001151.3(SLC25A4):
291
SLC25A4
[′AAGCAGCTCTTCTTAGGGGGTGTGGRTCG

c.311A > G (p.Asp104Gly)

GCATAAGCAGTTCTGGCGCTAC′]

4038
NM_013411.4(AK2): c.1A > G
204
AK2
[′GTGGCAGTGAGAGACTTCGGCGGACRTGG

(p.Met1Val)

CTCCCAGCGTGCCAGCGGCAGA′]

4039
NM_013411.4(AK2): c.494A > G
204
AK2
[′AACCCTCCAAAAGAGCCCATGAAAGRTGA

(p.Asp165Gly)

CGTATGTAAACTCAGGACAAAA′]

4040
NM_000476.2(AK1): c.491A > G
203
AK1
[′GCCACAGAACCCGTCATCGCCTTCTRTGAG

(p.Tyr164Cys)

AAACGTGGCATTGTGCGCAAG′]

4041
NM_001100.3(ACTA1): c.350A > G
58
ACTA1
[′GAGGCCCCCCTCAATCCCAAGGCCARCCG

(p.Asn117Ser)

CGAGAAGATGACCCAGATCATG′]

4042
NM_001103.3(ACTN2): c.26A > G
88
ACTN2
[′ATGAACCAGATAGAGCCCGGCGTGCRGTA

(p.Gln9Arg)

CAACTACGTGTACGACGAGGAT′]

4043
NM_005159.4(ACTC1):
−1
—
[′CAGCAAATGTGGATTAGCAAGCAAGRGTA

c.1088A > G (p.Glu363Gly)

CGATGAGGCAGGCCCATCCATT′]

4044
NM_005159.4(ACTC1): c.373A > G
−1
—
[′CAACCGGGAGAAGATGACTCAGATCRTGT

(p.Met125Val)

TTGAGACCTTCAATGTCCCTGC′]

4045
NM_018109.3(MTPAP):
55149
MTPAP
[′TGATTCTTCTCCTCTGTACATTCAGRATCC

c.1432A > G (p.Asn478Asp)

ATTTGAAACTTCTCTCAACAT′]

4046
NM_016955.3(SEPSECS):
51091
SEPSECS
[′TTATTGTCACTTGGATCAAATGGCTRTAAG

c.1001A > G (p.Tyr334Cys)

AAGCTACTAAAAGAAAGAAAG′]

4047
NM_014053.3(FLVCR1):
28982
FLVCR1
[′GATCTTCAGCCTGTACTCGCTGGTCRACGC

c.361A > G (p.Asn121Asp)

CTTTCAGTGGATCCAGTACAG′]

4048
NM_000021.3(PSEN1): c.697A > G
5663
PSEN1
[′ATATCTCATTATGATTAGTGCCCTCDTGGC

(p.Met233Val)

CCTGGTGTTTATCAAGTACCT′]

4049
NM_000207.2(INS): c.323A > G
−1
—
[′TGCTCCCTCTACCAGCTGGAGAACTRCTGC

(p.Tyr108Cys)

AACTAGACGCAGCCCGCAGGC′]

4050
NM_000334.4(SCN4A):
6329
SCN4A
[′GAAGCAGGCCTTCGACATCACCATCRTGA

c.4078A > G (p.Met1360Val)

TCCTCATCTGCCTCAACATGGT′]

4051
NM_000334.4(SCN4A):
6329
SCN4A
[′CCTCATCTGCCTCAACATGGTCACCRTGAT

c.4108A > G (p.Met1370Val)

GGTGGAGACAGACAACCAGAG′]

4052
NM_000518.4(HBB):
3043
HBB
[′TTCATACCTCTTATCTTCCTCCCACVGCTCC

c.316 − 2A > G

TGGGCAACGTGCTGGTCTGT′]

4053
NM_000525.3(KCNJ11):
3767
KCNJ11
[′GTGGCCCACAAGAACATCCGGGAGCRGGG

c.155A > G (p.Gln52Arg)

CCGCTTCCTGCAGGACGTGTTC′]

4054
NM_000525.3(KCNJ11):
3767
KCNJ11
[′AGCCCACCGCAGGGCTGAGACCCTCRTCTT

c.544A > G (p.Ile182Val)

CAGCAAGCATGCGGTGATCGC′]

4055
NM_000525.3(KCNJ11):
3767
KCNJ11
[′GGAAGGCGTGGTGGAAACCACGGGCVTCA

c.886A > G (p.Ile296Val)

CCACCCAGGCCCGCACCTCCTA′]

4056
NM_000525.3(KCNJ11):
3767
KCNJ11
[′GAGGACGGACGTTACTCTGTGGACTRCTCC

c.989A > G (p.Tyr330Cys)

AAGTTTGGCAACACCGTCAAA′]

4057
NM_000528.3(MAN2B1):
4125
MAN2B1
[′CCCATCTGTGGACCCTTTTCTGCCCRGCAC

c.1831 − 2A > G

ATCCGGGCAACGTTTGATCCT′]

4058
NM_000639.2(FASLG): c.466A > G
356
FASLG
[′ATTTATTTCAGGCAAGTCCAACTCARGGTC

(p.Arg156Gly)

CATGCCTCTGGAATGGGAAGA′]

4059
NM_000920.3(PC): c.1705A > G
5091
PC
[′CCCGGGGCTGCTGCTGATGGACACGRCCTT

(p.Thr569Ala)

CAGGGACGCCCACCAGTCACT′]

4060
NM_001017420.2(ESCO2):
157570
ESCO2
[′AATGGGTTTCTTTTTTTACCCCCCARTTATA

c.1132 − 7A > G

GGACGCTGGTCAGAAACATT′]

4061
NM_001017420.2(ESCO2):
157570
ESCO2
[′ATTAAATCATCTTTTCTTCTCTTTTRGGAAT

2c.1674 − A > G

TGCTTCATGTTTGGCTGTTT′]

4062
NM_001129765.1(NSDHL):
50814
NSDHL
[′GAGAGAGCCAAAAAGGCCATGGGCTVCCA

c.1046A > G (p.Tyr349Cys)

GCCACTAGTGACCATGGATGAT′]

4063
NM_001701.3(BAAT): c.967A > G
570
BAAT
[′AGAGGCCCAGGGGCAATTCCTCTTCRTTGT

(p.Ile323Val)

AGGAGAAGGTGATAAGACTAT′]

4064
NM_002977.3(SCN9A): c.406A > G
6335
SCN9A
[′ATTCAGCATGCTCATCATGTGCACTRTTCT

(p.Ile136Val)

GACAAACTGCATATTTATGAC′]

4065
NM_004004.5(GJB2): c.487A > G
2706
GJB2
[′CTATGTCATGTACGACGGCTTCTCCRTGCA

(p.Met163Val)

GCGGCTGGTGAAGTGCAACGC′]

4066
NM_004519.3(KCNQ3):
3786
KCNQ3
[′GAACCAAAGCCTGTTGGCTTAAACARTAA

c.1403A > G (p.Asn468Ser)

AGAGCGTTTCCGCACGGCCTTC′]

4067
NM_004519.3(KCNQ3):
3786
KCNQ3
[′AGAGATGATTATGTGTTCGGCCCCARTGG

c.2462A > G (p.Asn821Ser)

GGGGTCGAGCTGGATGAGGGAG′]

4068
NM_004519.3(KCNQ3): c.914A > G
3786
KCNQ3
[′AAAGAGGAGTTTGAGACCTATGCAGRTGC

(p.Asp305Gly)

CCTGTGGTGGGGCCTGGTGAGT′]

4069
NM_004525.2(LRP2):
4036
LRP2
[′TGTAACTCTCTCTTTTTCCCCCCACRGAAA

c.770 − 2A > G

GCGGTCCTCATGATGTTCATA′]

4070
NM_007375.3(TARDBP): c.1055A
23435
TARDBP
[′CAGAACCAGTCAGGCCCATCGGGTARTAA

> G (p.Asn352Ser)

CCAAAACCAAGGCAACATGCAG′]

4071
NM_007375.3(TARDBP): c.800A >
23435
TARDBP
[′AATGCCGAACCTAAGCACAATAGCARTAG

G (p.Asn267Ser)

ACAGTTAGAAAGAAGTGGAAGA′]

4072
NM_012434.4(SLC17A5): c.406A >
26503
SLC17A5
[′ATATGTTGCCAGCAAAATAGGGGGGDAAA

G (p.Lys136Glu)

TGCTGCTAGGATTTGGGATCCT′]

4073
NM_012463.3(ATP6V0A2):
23545
ATP6V0A
[′AGACTGTGTTCAACTCTTGTCTTCCRGCTA

c.732 − 2A > G

2
CCACTGCCACGTGTACCCCTA′]

4074
NM_014043.3(CHMP2B): c.85A > G
25978
CHMP2B
[′GTTACGAGGTACACAGAGGGCTATARTCA

(p.Ile29Val)

GAGATCGAGCAGCTTTAGAGAA′]

4075
NM_018136.4(ASPM):
25926
ASPM
[′AGCAAAATTATAATATTGGAATATARTATC

c.2761 − 25A > G
6

TGGAACTTATTTCTTTATAGG′]

4076
NM_022081.5(HPS4): c.461A > G
89781
HPS4
[′ATTCTGAAAAACACCAGTGATCTGCRTAA

(p.His154Arg)

GATTTTCAATTCCCTCTGGAAC′]

4077
NM_024649.4(BBS1):
−1
—
[′GTCAGCCTCTGGGACCCTTCTCCACRGCCA

c.1340 − 2A > G

TGCACCGGGCCTTCCAGACAG′]

4078
NM_032520.4(GNPTG):
84572
GNPTG
[′TGCTGCCCCTGCATCCTCCACCTTCRGGGC

2c.610 − A > G

CATGAGAAGTTGCTGAGGACA′]

4079
NM_172107.2(KCNQ2): c.1A > G
3785
KCNQ2
[′CCCGGGGCGCCTCCCGCCAGGCACCRTGG

(p.Met1Val)

TGCAGAAGTCGCGCAACGGCGG′]

4080
NM_172107.2(KCNQ2): c.356A > G
3785
KCNQ2
[′GTGTTTTCCACCATCAAGGAGTATGRGAA

(p.Glu119Gly)

GAGCTCGGAGGGGGCCCTCTAC′]

4081
NM_172107.2(KCNQ2): c.622A > G
3785
KCNQ2
[′CCTGCGCTTCCTGCAGATTCTGCGGRTGAT

(p.Met208Val)

CCGCATGGACCGGCGGGGAGG′]

4082
NM_172107.2(KCNQ2): c.635A > G
3785
KCNQ2
[′CAGATTCTGCGGATGATCCGCATGGRCCG

(p.Asp212Gly)

GCGGGGAGGCACCTGGAAGCTG′]

4083
NM_172107.2(KCNQ2): c.773A > G
3785
KCNQ2
[′GTGTACTTGGCAGAGAAGGGGGAGARCGA

(p.Asn258Ser)

CCACTTTGACACCTACGCGGAT′]

4084
NM_172107.2(KCNQ2):
3785
KCNQ2
[′ATGCTTTGGGGTCTCTGTTCCCGGTRGAGT

c.1764 − 2A > G

GGACCAGATCGTGGGGCGGGG′]

4085
NM_000495.4(COL4A5): c.1A > G
1287
COL4A5
[′AAGGAGCTGCGGGAGCCGGAGAAGARTG

(p.Met1Val)

AAACTGCGTGGAGTCAGCCTGGC′]

4086
NM_000495.4(COL4A5):
1287
COL4A5
[′AGAACTTCCATTGATGGCTTCTTTTRGGGT

2c.466 − A > G

GAACCAGGTAGTATAATTATG′]

4087
NM_000495.4(COL4A5):
1287
COL4A5
[′TCATTTTCTTTACTCACTTTATAACRGGGC

c.547 − 2A > G

CTACCTGGTCCCACTGGTATA′]

4088
NM_000495.4(COL4A5):
1287
COL4A5
[′ATTTTCTCTTTTGTCTTCTCTTCTTRGGGCC

c.610 − 2A > G

CTCCTGGTCCACCAGGACTT′]

4089
NM_000495.4(COL4A5):
1287
COL4A5
[′GCCCTATCATTTCTTTGTATCCTATRGGGT

c.892 − 2A > G

AAACCAGGCAAAGATGGAGAA′]

4090
NM_000495.4(COL4A5):
1287
COL4A5
[′TTGCTATCCTTTCTTTATCTTACTCRGGTGA

c.1340 − 2A > G

TGAGATATGTGAACCAGGCC′]

4091
NM_000495.4(COL4A5):
1287
COL4A5
[′TTCTTTGAACGTTTTCCTTTCAATARCTGCT

c.2042 − 18A > G

GTTTCTCCATAGGTGACCCT′]

4092
NM_000495.4(COL4A5):
1287
COL4A5
[′GTTAAAAAATGACTTATCATTTTACRGGCT

c.2147 − 2A > G

TTCCTGGAATTCCAGGACCTC′]

4093
NM_000495.4(COL4A5):
1287
COL4A5
[′GCTTAGATGGGCTCCCTGGACCAAARGGT

c.2394A > G (p.Lys798=)

ATGGAGGCTGTCACTGCATCTC′]

4094
NM_000495.4(COL4A5):
1287
COL4A5
[′CAGATACATCTTTTAAAACTGCTTCRGTAC

c.2510 − 33A > G

TTATTAATATTGATATTGTAT′]

4095
NM_000495.4(COL4A5):
1287
COL4A5
[′ATTCTTCAAAGGTACCAAAGGTGAARTGG

Gc.2692A > (p.Met898Val)

GTATGATGGGACCTCCAGGCCC′]

4096
NM_000495.4(COL4A5):
1287
COL4A5
[′AGGACCTTTGGGAATTCCTGGCAGGRGTG

c.2746A > G (p.Ser916Gly)

GTGTACCTGGTCTTAAAGGTAA′]

4097
NM_000495.4(COL4A5):
1287
COL4A5
[′ATATTATATATCACATATTTTCAACRGGGC

2c.3107 − A > G

CTCAGGGTGTGGAAGGGCCTC′]

4098
NM_000495.4(COL4A5):
1287
COL4A5
[′AACTGGGTGTAACCTGCTGTACTCARTTTT

c.3455 − 9A > G

TTAGGTGGTGGAGGTCATCCT′]

4099
NM_000495.4(COL4A5):
1287
COL4A5
[′TCTTCTAATTATACTTTACTTTCATRGGCCA

c.3605 − 2A > G

AAAGGGTGATGGAGGATTAC′]

4100
NM_000495.4(COL4A5):
1287
COL4A5
[′GTAACATTAATGATTTTATTTATTCRGGGT

c.3925 − 2A > G

AATCCTGGCCGGCCGGGTCTC′]

4101
NM_000495.4(COL4A5):
1287
COL4A5
[′ATAAAACTGTATGTACCTTCTGTGCDGGCA

c.3998 − 2A > G

TGAAAGGACCCAGTGGAGTAC′]

4102
NM_000495.4(COL4A5):
1287
COL4A5
[′GGATGGGATTCTCTGTGGATTGGTTRTTCC

Gc.4790A > (p.Tyr1597Cys)

TTCATGATGGTATTTTACACT′]

4103
NM_000495.4(COL4A5):
1287
COL4A5
[′CTGATTGTCTTATTTCTTATTTCCCRGTAAA

c.4977 − 2A > G

CCTCAGTCAGAAACGCTGAA′]

4104
NM_005359.5(SMAD4):
4089
SMAD4
[′TTTCATTTGTTTTCCCCTTTAAACARTTAAG

c.425 − 6A > G

ATCTCTCAGGATTAACACTG′]

4105
NM_005359.5(SMAD4): c.989A > G
4089
SMAD4
[′TATTGGTGTTCCATTGCTTACTTTGRAATG

(p.Glu330Gly)

GATGTTCAGGTAGGAGAGACA′]

4106
NM_020630.4(RET): c.1996A > G
5979
RET
[′CCACTGCTACCACAAGTTTGCCCACVAGCC

(p.Lys666Glu)

ACCCATCTCCTCAGCTGAGAT′]

4107
NM_020630.4(RET): c.2342A > G
5979
RET
[′CTGTCAGAGTTCAACGTCCTGAAGCRGGTC

(p.Gln781Arg)

AACCACCCACATGTCATCAAA′]

4108
NM_000060.3(BTD): c.194A > G
686
BTD
[′TATTATGTGGCTGCCGTGTATGAGCRTCCA

(p.His65Arg)

TCCATCCTGAGTCTGAACCCT′]

4109
NM_000060.3(BTD): c.278A > G
686
BTD
[′CTCATGAACCAGAACCTTGACATCTRTGAA

(p.Tyr93Cys)

CAGCAAGTGATGACTGCAGCC′]

4110
NM_000060.3(BTD): c.356A > G
686
BTD
[′CCAGAAGATGGCATTCATGGATTCARCTTT

(p.Asn119Ser)

ACAAGAACATCCATTTATCCA′]

4111
NM_000060.3(BTD): c.364A > G
686
BTD
[′TGGCATTCATGGATTCAACTTTACARGAAC

(p.Arg122Gly)

ATCCATTTATCCATTTTTGGA′]

4112
NM_000060.3(BTD): c.515A > G
686
BTD
[′AGGGGAGATATGTTCTTGGTGGCCARTCTT

(p.Asn172Ser)

GGGACAAAGGAGCCTTGTCAT′]

4113
NM_000060.3(BTD): c.583A > G
686
BTD
[′CCCAAAAGATGGGAGATACCAGTTCRACA

(p.Asn195Asp)

CAAATGTCGTGTTCAGCAATAA′]

4114
NM_000060.3(BTD): c.584A > G
686
BTD
[′CCAAAAGATGGGAGATACCAGTTCARCAC

(p.Asn195Ser)

AAATGTCGTGTTCAGCAATAAT′]

4115
NM_000060.3(BTD): c.641A > G
686
BTD
[′CTTGTTGACCGCTACCGTAAACACARCCTC

(p.Asn214Ser)

TACTTTGAGGCAGCATTCGAT′]

4116
NM_000060.3(BTD): c.880A > G
686
BTD
[′GAAAGCTTTTGCTGTTGCCTTTGGCRTCAA

(p.Ile294Val)

CGTTCTGGCAGCTAATGTCCA′]

4117
NM_000060.3(BTD): c.1205A > G
686
BTD
[′TTTCACTCTGAGATGATGTATGACARTTTC

(p.Asn402Ser)

ACCCTGGTCCCTGTCTGGGGA′]

4118
NM_000060.3(BTD): c.1313A > G
686
BTD
[′AGGCCCACCTTATCCAAAGAGCTGTRTGCC

(p.Tyr438Cys)

CTGGGGGTCTTTGATGGGCTT′]

4119
NM_000060.3(BTD): c.1619A > G
686
BTD
[′ACGGCGGCTCTCTATGGGCGCTTGTRTGAG

(p.Tyr540Cys)

AGGGACTAGGAAAAGTGTGTG′]

4120
NM_000155.3(GALT): c.1A > G
2592
GALT
[′TTCCAGCGGATCCCCCGGTGGCCTCRTGTC

(p.Met1Val)

GCGCAGTGGAACCGATCCTCA′]

4121
NM_000155.3(GALT): c.67A > G
2592
GALT
[′GTCAGAGGCGGACGCCGCAGCAGCARCCT

(p.Thr23Ala)

TCCGGGCAAACGGTAACTGCAC′]

4122
NM_000155.3(GALT):
2592
GALT
[′GTGCTTCTAGCCTATCCTTGTCGGTRGGTG

c.253 − 2A > G

AATCCCCAGTACGATAGCACC′]

4123
NM_000155.3(GALT): c.290A > G
2592
GALT
[′TACGATAGCACCTTCCTGTTTGACARCGAC

(p.Asn97Ser)

TTCCCAGCTCTGCAGCCTGAT′]

4124
NM_000155.3(GALT): c.308A > G
2592
GALT
[′TTTGACAACGACTTCCCAGCTCTGCRGCCT

(p.Gln103Arg)

GATGCCCCCAGTCCAGGTAAC′]

4125
NM_000155.3(GALT): c.379A > G
2592
GALT
[′ATCTTTTCTCCCGTCACCACCCAGTRAGGT

(p.Lys127Glu)

CATGTGCTTCCACCCCTGGTC′]

4126
NM_000155.3(GALT): c.424A > G
2592
GALT
[′CTGGTCGGATGTAACGCTGCCACTCRTGTC

(p.Met142Val)

GGTCCCTGAGATCCGGGCTGT′]

4127
NM_000155.3(GALT):
2592
GALT
[′TTCTTCTCTGCTTTTGCCCCTTGACRGGTAT

c.565 − 2A > G

GGGCCAGCAGTTTCCTGCCA′]

4128
NM_000155.3(GALT): c.574A > G
2592
GALT
[′TTTTGCCCCTTGACAGGTATGGGCCRGCAG

(p.Ser192Gly)

TTTCCTGCCAGATATTGCCCA′]

4129
NM_000155.3(GALT): c.626A > G
2592
GALT
[′CGTGAGGAGCGATCTCAGCAGGCCTVTAA

(p.Tyr209Cys)

GAGTCAGCATGGAGAGCCCCTG′]

4130
NM_000155.3(GALT): c.752A > G
2592
GALT
[′GTCCCCTTCTGGGCAACATGGCCCTVCCAG

(p.Tyr251Cys)

ACACTGCTGCTGCCCGTCGGC′]

4131
NM_000155.3(GALT): c.812A > G
2592
GALT
[′CGGCTACCTGAGCTGACCCCTGCTGRGCGT

(p.Glu271Gly)

GATGGTCAGTCTCCCAAGTAG′]

4132
NM_000155.3(GALT):
2592
GALT
[′AGGCTGAGAGTCAGGCTCTGATTCCRGAT

c.821 − 2A > G

CTAGCCTCCATCATGAAGAAGC′]

4133
NM_000155.3(GALT): c.854A > G
2592
GALT
[′TCCATCATGAAGAAGCTCTTGACCARGTAT

(p.Lys285Arg)

GACAACCTCTTTGAGACGTCC′]

4134
NM_000155.3(GALT): c.968A > G
2592
GALT
[′CATTGGCAGCTGCACGCTCATTACTRCCCT

(p.Tyr323Cys)

CCGCTCCTGCGCTCTGCCACT′]

4135
NM_000155.3(GALT): c.1001A > G
2592
GALT
[′CTCCTGCGCTCTGCCACTGTCCGGARATTC

(p.Lys334Arg)

ATGGTTGGCTACGAAATGCTT′]

4136
NM_000155.3(GALT): c.1048A > G
2592
GALT
[′GCTTGCTCAGGCTCAGAGGGACCTCRCCCC

(p.Thr350Ala)

TGAGCAGGTCAGGACTCAGAA′]

4137
NM_000155.3(GALT): c.1132A > G
2592
GALT
[′GCAGAAGGACAGGGAGACAGCAACCRTCG

(p.Ile378Val)

CCTGACCACGCCGACCACAGGG′]

4138
NM_000553.4(WRN): c.403A > G
7486
WRN
[′GTTGCTTGAAAATAAAGCAGTTAAARAGG

(p.Lys135Glu)

CAGGTGTAGGAATTGAAGGAGA′]

4139
NM_000433.3(NCF2): c.481A > G
4688
NCF2
[′CTTACCCAGACACACTCCATCGCCTYGTCG

(p.Lys161Glu)

ATTTTGGAATGTCTGGGCTCA′]

4140
NM_198056.2(SCN5A):
6331
SCN5A
[′ACAGCGGGGGAGAGCGAGAGCCACCRCAC

c.1673A > G (p.His558Arg)

ATCACTGCTGGTGCCCTGGCCC′]

4141
NM_000074.2(CD40LG):
959
CD40LG
[′CAAATTGCGGCACATGTCATAAGTGRGGC

c.386A > G (p.Glu129Gly)

CAGCAGTAAAACAACATCTGGT′]

4142
NM_002863.4(PYGL): c.1016A > G
5836
PYGL
[′CCCACCCAGGTGGCCATCCAGCTGARTGA

(p.Asn339Ser)

CACTCACCCTGCACTCGCGATC′]

4143
NM_000142.4(FGFR3):
2261
FGFR3
[′CCCCTTGGGGAGGGCTGCTTCGGCCRGGT

c.1454A > G (p.Gln485Arg)

GGTCATGGCGGAGGCCATCGGC′]

4144
NM_001101.3(ACTB): c.34A > G
60
ACTB
[′TGATATCGCCGCGCTCGTCGTCGACVACG

(p.Asn12Asp)

GCTCCGGCATGTGCAAGGCCGG′]

4145
NM_001202.3(BMP4): c.362A > G
652
BMP4
[′TGGGGGAAGAGACTGACCTTCGTGGYGGA

(p.His121Arg)

AGCTCCTCACGGTGTTGGCCCG′]

4146
NM_000094.3(COL7A1):
1294
COL7A1
[′CAGCTGGCCCGACCTGGTGTCCCCARGGT

c.425A > G (p.Lys142Arg)

GATCCCTACCCCTACCATGCCT′]

NM_001130823.1(DNMT1):
1786
DNMT1
[]

c.1532A > G (p.Tyr511Cys)

4147
NM_000138.4(FBN1): c.5096A > G
2200
FBN1
[′AGAAGAAGTTTGTGCTACAGAAACTRCTA

(p.Tyr1699Cys)

TGCTGACAACCAGACCTGTGAT′]

4148
NM_000138.4(FBN1): c.5087A > G
2200
FBN1
[′CTAGATATGAGAAGAAGTTTGTGCTRCAG

(p.Tyr1696Cys)

AAACTACTATGCTGACAACCAG′]

4149
NM_000138.4(FBN1): c.5099A > G
2200
FBN1
[′AGAAGTTTGTGCTACAGAAACTACTRTGCT

(p.Tyr1700Cys)

GACAACCAGACCTGTGATGGA′]

4150
NM_001244710.1(GFPT1):
2673
GFPT1
[′TTACTTAAACTACCATGTTCCTCGARCGAG

c.43A > G (p.Thr15Ala)

ACGAGAAATCCTGGAGACCCT′]

4151
NM_002292.3(LAMB2): c.440A > G
3913
LAMB2
[′CTGGAGGCTGAGTTTCATTTCACACRCCTC

(p.His 147Arg)

ATTATGACCTTCAAGGTGCCT′]

4152
NM_005211.3(CSF1R):
1436
CSF1R
[′GACTTAAGGGACCTGTGTGCGTGGCRGGT

c.1754 − 2A > G

AAGACCCTCGGAGCTGGAGCCT′]

4153
NM_005247.2(FGF3): c.146A > G
2248
FGF3
[′GGGGCGCCCCGGCGCCGCAAGCTCTRCTG

(p.Tyr49Cys)

CGCCACGAAGTACCACCTCCAG′]

4154
NM_005247.2(FGF3): c.317A > G
2248
FGF3
[′GCCATGAACAAGAGGGGACGACTCTRTGC

(p.Tyr106Cys)

TTCGGTGAGTCCAGGCTGTCAC′]

4155
NM_005188.3(CBL): c.1112A > G
867
CBL
[′TAATCAAAGGAACAATATGAATTATRCTG

(p.Tyr371Cys)

TGAGATGGGCTCCACATTCCAA′]

4156
NM_000313.3(PROS1): c.701A > G
5627
PROS1
[′TGTGAATGCCCCGAAGGCTACAGATRTAA

(p.Tyr234Cys)

TCTCAAATCAAAGTCTTGTGAA′]

4157
NM_000329.2(RPE65):
6121
RPE65
[′TACCAGAAGTATTGTGGGAAACCTTRCAC

c.1292A > G (p.Tyr431Cys)

ATATGCGTATGGACTTGGCTTG′]

4158
NM_001040142.1(SCN2A):
6326
SCN2A
[′TGAATCTTTTCATTGGTGTCATCATRGATA

c.4419A > G (p.Ile 1473Met)

ACTTCAACCAACAGAAAAAGA′]

4159
NM_001040142.1(SCN2A):
6326
SCN2A
[′GTCAGTGAAGAAGCTTTCTGATGTCRTGAT

c.754A > G (p.Met252Val)

CTTGACTGTGTTCTGTCTAAG′]

4160
NM_004612.3(TGFBR1):
7046
TGFBR1
[′TTCTGCCACCTCTGTACAAAAGACARTTTT

c.134A > G (p.Asn45Ser)

ACTTGTGTGACAGATGGGCTC′]

4161
NM_003688.3(CASK): c.2168A > G
8573
CASK
[′TTTGATCAATTAGATCTTGTCACATRTGAA

(p.Tyr723Cys)

GAAGTAGTAAAACTGCCAGCA′]

4162
NM_015884.3(MBTPS2):
51360
MBTPS2
[′GGTGGCAGTGTACTTTTGGCTGCCARTGTG

c.1523A > G (p.Asn508Ser)

ACCCTGGGACTCTGGATGGTT′]

4163
m.10450A > G
4573
MT-TR
[′ACGAATGATTTCGACTCATTAAATTRTGAT

AATCATATTTACCAAATGCCC′]

4164
m.5816A > G
4511
MT-TC
[′GAATTTGCAATTCAATATGAAAATCRCCTC

GGAGCTGGTAAAAAGAGGCCT′]

4165
m.608A > G
4558
MT-TF
[′GTAGCTTACCTCCTCAAAGCAATACRCTGA

AAATGTTTAGACGGGCTCACA′]

4166
NM_172337.2(OTX2): c.674A > G
5015
OTX2
[′CTGATTGAGATGGCTGGTGACTGCAYTGG

(p.Asn225Ser)

TACCCATGGGACTGAGTGTGGC′]

4167
NM_001376.4(DYNC1H1):
1778
DYNC1H1
[′CTCCTGACTCTGGATATCTTGAAACRTGGC

c.917A > G (p.His306Arg)

AAGCGCTTCCATGCCACCGTC′]

4168
NM_001376.4(DYNC1H1):
1778
DYNC1H1
[′GAAGCGGGTGGAAGATGTCCTTGGCRAGG

c.2011A > G (p.Lys671Glu)

GCTGGGAGAATCACGTGGAGGG′]

4169
NM_001376.4(DYNC1H1):
1778
DYNC1H1
[′CTAAGAATAACCAATCAGGTAATCTRCTTG

c.2909A > G (p.Tyr970Cys)

AATCCACCAATTGAAGAGTGC′]

4170
NM_004380.2(CREBBP):
1387
CREBBP
[′ACTGTAGGGGTGCTCTGGGTTTGGGHAGC

c.2728A > G (p.Thr910Ala)

ACTGGGCACTGAGCCAGGAGTC′]

4171
NM_000459.4(TEK): c.2690A > G
7010
TEK
[′ATGCTCTCTTCCTTCCCTCCAGGCTVCTTGT

(p.Tyr897Cys)

ACCTGGCCATTGAGTACGCG′]

4172
NM_001354.5(AKR1C2):
1646
AKR1C2
[′AGATGGCAGTGTGAAGAGAGAAGACRTAT

c.235A > G (p.Ile79Val)

TCTACACTTCAAAGGTACTGTG′]

4173
NM_007315.3(STAT1): c.604A > G
6772
STAT1
[′ACAAGAACAGCTGTTACTCAAGAAGRTGT

(p.Met202Val)

ATTTAATGCTTGACAATAAGAG′]

4174
NM_007315.3(STAT1): c.494A > G
6772
STAT1
[′GAGCATGAAATCAAGAGCCTGGAAGRTTT

(p.Asp165Gly)

ACAAGATGAATATGACTTCAAA′]

4175
NM_007315.3(STAT1): c.862A > G
6772
STAT1
[′GTTGGAGGAATTGGAACAGAAATACRCCT

(p.Thr288Ala)

ACGAACATGACCCTATCACAAA′]

4176
NM_002052.4(GATA4): c.928A > G
2626
GATA4
[′CCTCCAGGTCCCCAGGCCTCTTGCARTGCG

(p.Met310Val)

GAAAGAGGGGATCCAAACCAG′]

4177
NM_014191.3(SCN8A):
6334
SCN8A
[′CATGTACATTGCCATCATCCTGGAGRACTT

c.5302A > G (p.Asn1768Asp)

CAGTGTAGCCACAGAGGAAAG′]

4178
NM_000209.3(PDX1): c.533A > G
3651
PDX1
[′TACATCTCACGGCCGCGCCGGGTGGRGCT

(p.Glu178Gly)

GGCTGTCATGTTGAACTTGACC′]

4179
NM_000890.3(KCNJ5): c.472A > G
3762
KCNJ5
[′CATTGGGTATGGCTTCCGAGTCATCRCAGA

(p.Thr158Ala)

GAAGTGTCCAGAGGGGATTAT′]

4180
NM_000256.3(MYBPC3):
4607
MYBPC3
[′ACGGTCGAGGGGGCAGAGAAGGAAGRTG

c.2234A > G (p.Asp745Gly)

AGGGCGTCTACACGGTCACAGTG′]

4181
NM_005359.5(SMAD4):
4089
SMAD4
[′TGTTGATGACCTTCGTCGCTTATGCRTACT

c.1498A > G (p.Ile500Val)

CAGGATGAGTTTTGTGAAAGG′]

4182
NM_005359.5(SMAD4):
4089
SMAD4
[′TTGATGACCTTCGTCGCTTATGCATRCTCA

c.1500A > G (p.Ile500Met)

GGATGAGTTTTGTGAAAGGCT′]

4183
NM_001184.3(ATR): c.6431A > G
545
ATR
[′TATCAATTTTTGACTGCTTTTTCACRATTGA

(p.Gln2144Arg)

TCTCTCGAATTTGTCATTCT′]

4184
NM_153427.2(PITX2): c.262A > G
5308
PITX2
[′CCCCAACCGCCCCCAGGTTTGGTTCRAGAA

(p.Lys88Glu)

TCGTCGGGCCAAATGGAGAAA′]

4185
NM_005257.5(GATA6):
2627
GATA6
[′CTGTGCCAACTGTCACACCACAACTRCCAC

c.1354A > G (p.Thr452Ala)

CTTATGGCGCAGAAACGCCGA′]

4186
NM_005257.5(GATA6):
2627
GATA6
[′AAACGCCGAGGGTGAACCCGTGTGCVATG

c.1396A > G (p.Asn466Asp)

CTTGTGGACTCTACATGAAACT′]

4187
NM_000414.3(HSD17B4):
3295
HSD17B4
[′CTTGTGGAAGCCCTGAAGCCAGAGTRTGT

c.650A > G (p.Tyr217Cys)

GGCACCTCTTGTCCTTTGGCTT′]

4188
NM_004153.3(ORC1): c.380A > G
4998
ORC1
[′GCCTGTGACAGCAACATTAATGCGGRGAC

(p.Glu127Gly)

CATCATTGGCCTTGTTCGGGTA′]

4189
NM_002552.4(ORC4): c.521A > G
5000
ORC4
[′CATCATAAAAACCAAACACTTCTCTRTAAT

(p.Tyr174Cys)

CTTTTTGACATTTCTCAGTCT′]

4190
NM_004656.3(BAP1):
8314
BAP1
[′GCTCCACTAGGTTGGCCAGCATGCCYGCG

c.2057 − 2A > G

AAGAGGTAGAGACCCTTGAGCA′]

4191
NM_004656.3(BAP1):
8314
BAP1
[′TCAGGGAGGTGGCGTGGCTCGGGCCYGGG

c.438 − 2A > G

GAAAAACAGAGTCAGGGCCCAA′]

NM_003590.4(CUL3): c.1238A > G
8452
CUL3
[]

(p.Asp413Gly)

4192
NM_004813.2(PEX16): c.992A > G
9409
PEX16
[′TACTTGCCCACCTGGCAGAAAATCTRCTTC

(p.Tyr331Cys)

TACAGTTGGGGCTGACAGACC′]

4193
NM_004544.3(NDUFA10): c.1A > G
4705
NDUFA10
[′TTGATCCTGAGCTGACCGGGTAGCCRTGGC

(p.Met1Val)

CTTGCGGCTCCTGAAGCTGGC′]

4194
NM_004544.3(NDUFA10):
4705
NDUFA10
[′TGGTTGTACAGCAGTCGCCTGCTGCRGTAC

c.425A > G (p.Gln142Arg)

TCAGATGCCTTGGAGCACTTG′]

4195
NM_006796.2(AFG3L2):
10939
AFG3L2
[′TATTTTTCAGATTGTTCAGTTTGGCDTGAA

c.1996A > G (p.Met666Val)

TGAAAAGGTTGGGCAAATCTC′]

4196
NM_006796.2(AFG3L2):
10939
AFG3L2
[′TATTTACCAAAAGAACAATACCTCTRTACC

c.1847A > G (p.Tyr616Cys)

AAAGAGCAGCTCTTGGATAGG′]

4197
NM_001199397.1(NEK1):
4750
NEK1
[′CAAAATTCTTTGTATCTTTTCATCTRGCTA

c.869 − 2A > G

AAAGACCAGCTTCAGGACAAA′]

4198
NM_006587.3(CORIN): c.949A > G
10699
CORIN
[′GAATCTGTTTCACTGTCACACAGGCRAGTG

(p.Lys317Glu)

CCTTAATTACAGCCTTGTGTG′]

4199
NM_006587.3(CORIN):
10699
CORIN
[′CATGAATTTGCCCTACAACAGTACARGTTA

c.1414A > G (p.Ser472Gly)

TCCAAATTATTTTGGCCACAG′]

4200
NM_015560.2(OPA1): c.1294A > G
4976
OPA1
[′AGCTTACATGCAGAATCCTAATGCCRTCAT

(p.Ile432Val)

ACTGTGTATTCAAGGTAAATC′]

4201
NM_021625.4(TRPV4):
59341
TRPV4
[′CGTGGGCTGAAGCTGACGGGGACCTRTAG

c.1805A > G (p.Tyr602Cys)

CATCATGATCCAGAAGGTACGG′]

4202
NM_021625.4(TRPV4): c.590A > G
59341
TRPV4
[′TCTACGGGGAAGACCTGCCTGCCCARGGC

(p.Lys197Arg)

CTTGCTGAACCTGAGCAATGGC′]

4203
NM_021625.4(TRPV4): c.826A > G
59341
TRPV4
[′GGCCCGTGGGCGCTTCTTCCAGCCCRAGG

(p.Lys276Glu)

ATGAGGGGGGCTACTTCTACTT′]

4204
NM_024022.2(TMPRSS3):
64699
TMPRSS3
[′GTCTCGGATTGCAAAGACGGGGAGGREGA

c.308A > G (p.Asp103Gly)

GTACCGCTGTGGTAAGGTCATG′]

4205
NM_016599.4(MYOZ2): c.738A > G
51778
MYOZ2
[′GATGGATATCTGAGAATATTCCTATRGTGA

(p.Ile246Met)

TAACAACCGAACCTACAGATG′]

NM_017415.2(KLHL3):
26249
KLHL3
[]

c.1670A > G (p.Tyr557Cys)

4206
NM_019109.4(ALG1): c.1129A > G
56052
ALG1
[′GTCCTCCAGTGGCCTGGACCTGCCCRTGAA

(p.Met377Val)

GGTGGTGGACATGTTCGGGTG′]

4207
NM_031885.3(BBS2):
583
BBS2
[′GCTAATGGTTTGGGGTTTTATTTTCRGGTT

c.472 − 2A > G

ACTGGAGACAATGTTAATTCC′]

4208
NM_006886.3(ATP5E): c.35A > G
−1
—
[′TACCTTCTCTCATTTTCTCCCAGCTRCATCC

(p.Tyr12Cys)

GATACTCCCAGATCTGTGCA′]

4209
NM_022445.3(TPK1): c.656A > G
27010
TPK1
[′CACAACACCAGACCCGTCGTAGGTAYTGG

(p.Asn219Ser)

AAGTACTGACCAATGTTCCAAA′]

4210
NM_000017.3(ACADS):
35
ACADS
[′CTCTGACTGTACCCCCATGTTTAGGRGGCA

c.1031A > G (p.Glu344Gly)

GCCATGGCCAAGCTGGCCGCC′]

4211
NM_016013.3(NDUFAF1):
51103
NDUFAF1
[′GGGGGACCCTACTGGCAGGAGGTCARGGT

c.758A > G (p.Lys253Arg)

AACAGCATAAATCTTCATTGTT′]

4212
NM_032580.3(HES7): c.172A > G
84667
HES7
[′GAACCCGAAGCTGGAGAAAGCGGAGRTAT

(p.Ile58Val)

TGGAGTTCGCCGTGGGCTACTT′]

4213
NM_024887.3(DHDDS): c.124A > G
79947
DHDDS
[′GGACGGGAACCGTCGCTATGCCAAGRAGT

(p.Lys42Glu)

GCCAGGTGGAGCGGCAGGAAGG′]

4214
NM_024700.3(SNIP1):
79753
SNIP1
[′CTCAAATTTGGATTCAGTAGCAGAGRATA

c.1097A > G (p.Glu366Gly)

CGTCTTGCTCCATGAGTCGTCG′]

4215
NM_206933.2(USH2A):
7399
USH2A
[′AATTGAACACCTCTCCTTTCCCAAGRTAAG

2c.7595 − 144A > G

AGATCATCTTTAAGAAAAGGC′]

4216
NM_016952.4(CDON): c.2368A > G
50937
CDON
[′GTTTTTGTTTTCCCTCAAAGGTTCARCATA

(p.Thr790Ala)

CAAATTTAGGGTCATTGCCAT′]

4217
NM_020435.3(GJC2):
57165
GJC2
[′AGACCCTGAGGCCGAGGGGGGAACARTGG

c.−167A > G

GGCCCTTGAGGGCCCCTCCTCC′]

4218
NM_024549.5(TCTN1):
79600
TCTN1
[′TGGATCCTACCCCTCTTTTTTCTGCRGTTGC

c.221 − 2A > G

TGTTCTCTGTGTCTGTGACT′]

4219
NM_031427.3(DNAL1): c.449A > G
83544
DNAL1
[′CTCGAAGACCTGGTGTTTGTAGGCARTCCC

(p.Asn150Ser)

TTGGAAGAGAAACATTCTGCT′]

4220
NM_145046.4(CALR3): c.245A > G
125972
CALR3
[′AGTTTTCCCTTTATTGCTGAACGGTYTGAA

(p.Lys82Arg)

GCGTGCAGAGATGGCATAGAA′]

4221
NM_020320.3(RARS2):
57038
RARS2
[′AATGGACAAGTATAATTTTGATACARTGAT

c.1024A > G p.Met342Val)

ATATGTGGTAAGTAATCAGAA′]

4222
NM_020320.3(RARS2): c.35A > G
57038
RARS2
[′CTCTGCGCGCTCCGGGATCCATACCYGGC

(p.Gln12Arg)

AAGCAATAGCGCGGCGAAAGCC′]

4223
NM_001017361.2(KHDC3L):
154288
KHDC3L
[′TGTCTCCTGCAGGACCGGCCGCAGCRTGG

c.1A> G (p.Met1Val)

ACGCTCCCAGGCGGTTTCCGAC′]

4224
NM_024753.4(TTC21B):
79809
TTC21B
[′TAATCGTGCCAGTTCCAACATAATCYGTAG

c.2758 − 2A > G

AGCAAAGGGCTAGATTCATCA′]

4225
NM_001145901.1(SARS2):
54938
SARS2
[′TTCGTCCTTGACCGCAGGGTCCTGGRTATG

c.1175A > G (p.Asp392Gly)

CCCACCCAAGAACTGGGCCTC′]

4226
NM_000552.3(VWF): c.3437A > G
7450
VWF
[′AACGGGTATGAGTGTGAGTGGCGCTRTAA

(p.Tyr1146Cys)

CAGCTGTGCACCTGCCTGTCAA′]

4227
NM_014985.3(CEP152):
22995
CEP152
[′ACCTTACCTATCCACAGCTTCTTGTYTGTC

c.2000A > G (p.Lys667Arg)

ATGGTCAAAATCTTGTACCAT′]

4228
NM_024809.4(TCTN2):
79867
TCTN2
[′GCTGAGAAATGTCTTACTCTCTTGCRGGGA

c.1506 − 2A > G

GAATGCTGTTGAAAGACTTGA′]

4229
NM_198994.2(TGM6): c.980A > G
343641
TGM6
[′CGGACCCTGGAGGACCTGACAGAAGRCAG

(p.Asp327Gly)

CATGTGGTGGGTCCTGCCCCCA′]

4230
NM_052873.2(IFT43): c.1A > G
112752
IFT43
[′GAAGTGACGTCAGGCGGCCGCGGAGRTGG

(p.Met1Val)

AGGATTTGCTCGACTTGGACGA′]

4231
NM_201269.2(ZNF644):
84146
ZNF644
[′AACATTTGGATCAACCTCACAATCARGTA

c.2014A > G (p.Ser672Gly)

GTTTTTCAAAAATTCATAAGCG′]

4232
NM_201269.2(ZNF644):
84146
ZNF644
[′GTAGTAAAAGGACACATCTTACATAYGTA

c.1759A > G (p.Ile587Val)

GGTAGCTGATTTTTTGGATGAT′]

4233
NM_018699.3(PRDM5): c.320A > G
11107
PRDM5
[′TTTCAGGAAGGAGAAAACATTTTCTRTTTG

(p.Tyr107Cys)

GCAGTTGAAGATATAGAAACA′]

4234
NM_001198799.2(ASCC1):
51008
ASCC1
[′CTATAGTTCTCTGGGGGACTTACCAYTGGG

c.953A > G (p.Asn318Ser)

GTCTTTCCTGAATAGTGTATT′]

4235
NM_007055.3(POLR3A):
11128
POLR3A
[′ACCAACTGAGTTTTTCTTCCACACARTGGC

c.2554A > G (p.Met852Val)

CGGCCGGGAAGGTCTAGTCGA′]

4236
NM_001256047.1(C19orf12):
83636
C19orf12
[′TACTGGATCTCGGCCCGCAGCTCCTYGGTG

c.391A > G (p.Lys131Glu)

ACGTAGTTCACCAGCATGGCC′]

4237
NM_016464.4(TMEM138):
51524
TMEM138
[′TACTTTGCCCTCAGCATCTCCCTTCRTGTCT

c.287A > G (p.His96Arg)

GGGTCATGGTAAGAGTGGCA′]

4238
NM_016464.4(TMEM138):
51524
TMEM138
[′TTCCTCCCCACAGCAGCAGTGTTGTRCTGC

c.389A > G (p.Tyr130Cys)

TACTTCTATAAACGGACAGCC′]

4239
NM_177965.3(C8orf37):
157657
C8orf37
[′AAAGGAACACGGGCATATGCCTGCCRGTG

c.545A > G (p.Gln182Arg)

TAGCTGGAGAACTATTGAAGAA′]

4240
NM_001004334.3(GPR179):
440435
GPR179
[′CCCAAGTGGCCGCAGGCAGATGGATRTGT

c.659A > G (p.Tyr220Cys)

GGGGGACACGCAGCAGGTGAGG′]

4241
NM_004963.3(GUCY2C):
2984
GUCY2C
[′AGCAGTGAGACATACTTTCTTGGTGYCCAC

c.1160A > G (p.Asp387Gly)

AGAGGTATACAGAAGCACCAT′]

4242
NM_024110.4(CARD14):
79092
CARD14
[′AGCCTGCAGGAGGAGCTGAACCAGGRAAA

c.425A > G (p.Glu142Gly)

GGGGCAGAAGGAGGTGCTGCTG′]

4243
NM_018105.2(THAP1): c.70A > G
55145
THAP1
[′CAAGGACAAGCCCGTTTCTTTCCACRAGTG

(p.Lys24Glu)

AGGACCCTGCGCGCCTCGCGG′]

4244
NM_000933.3(PLCB4):
5332
PLCB4
[′AACAAACGGCAAATGAGTCGCATTTRCCC

c.1868A > G (p.Tyr623Cys)

CAAGGGAGGCCGAGTCGATTCC′]

4245
NM_001172646.1(PLCB4):
5332
PLCB4
[′CACTACTTCATCAGTTCTTCCCATAVCACT

c.986A > G (p.Asn329Ser)

TATCTCACTGGCAGACAGTTC′]

4246
NM_005850.4(SF3B4): c.1A > G
10262
SF3B4
[′GGGAGACGGCGGGATCTCTTTCGCCRTGG

(p.Met1Val)

CTGCCGGGCCGATCTCCGAGCG′]

4247
NM_014714.3(IFT140):
9742
IFT140
[′TGGGACATAGAACGAGGAGAGAATTRTAT

c.932A > G (p.Tyr311Cys)

ACTGAGTCCAGATGAGAAGTTT′]

4248
NM_000258.2(MYL3): c.517A > G
4634
MYL3
[′GACAGAAGACGAAGTGGAGAAGTTGRTGG

(p.Met173Val)

CTGGGCAAGAGGACTCCAATGG′]

4249
NM_032578.3(MYPN): c.59A > G
84665
MYPN
[′ATATCTCAGCTTCTAAGAGAGAGCTRTTTA

(p.Tyr20Cys)

GCTGAAACCAGACATCGGGGA′]

4250
NM_001018005.1(TPM1):
7168
TPM1
[′TGAGTTTGCGGAGAGGTCAGTAACTRAAT

c.742A > G (p.Lys248Glu)

TGGAGAAAAGCATTGATGACTT′]

4251
NM_005006.6(NDUFS1):
4719
NDUFS1
[′AGCTGCTTACACAGAGAAGTCTGCTRCAT

Gc.1783A > (p.Thr595Ala)

ATGTCAACACTGAGGGTAGAGC′]

4252
NM_033360.3(KRAS): c.439A > G
3845
KRAS
[′AATTCCTTTTATTGAAACATCAGCARAGAC

(p.Lys147Glu)

AAGACAGGTAAGTAACACTGA′]

4253
NM_014236.3(GNPAT):
8443
GNPAT
[′GAAGATGAACTCATCTGCAAAAACAHCAC

c.1556A > G (p.Asp519Gly)

GTAGGAAGCGAAAGCAACTGTA′]

4254
NM_017565.3(FAM20A):
−1
—
[′GGCACCCGTCGGAAGTCCAGAATCCYGCA

c.813 − 2A > G

AGAGAGGAAGCTCTGTTCCATC′]

4255
NM_017565.3(FAM20A):
54757
FAM20A
[′AGGCTTTCTCATCTTGACTGTAATCYGCAA

c.590 − 2A > G

AGGAGGAGAAGGGCAATGAGA′]

4256
NM_017636.3(TRPM4):
54795
TRPM4
[′CTGCTTCACATCTTCACGGTCAACARACAG

c.2741A > G (p.Lys914Arg)

CTGGGGCCCAAGATCGTCATC′]

4257
NM_000076.2(CDKNIC):
1028
CDKNIC
[′GCTGTCGCCCGCAGATTTCTTCGCCRAGCG

Gc.832A > (p.Lys278Glu)

CAAGAGATCAGCGCCTGAGAA′]

4258
NM_022912.2(REEP1):
65055
REEP1
[′AGTGTGCCTCTGTTTTTCCTTTGACRGGAA

c.304 − 2A > G

ATCGATGATTGTCTGGTCCAA′]

4259
NM_000053.3(ATP7B):
540
ATP7B
[′TGTGACATTCTTCGACACGCCCCCCRTGCT

c.2305A > G (p.Met769Val)

CTTTGTGTTCATTGCCCTGGG′]

4260
NM_000053.3(ATP7B):
540
ATP7B
[′GTCCACACCCATGCTCTGCAGCGTGYGCA

c.3620A > G (p.His1207Arg)

CAGCCAGGGCAGCCTCCTGCTT′]

4261
NM_000492.3(CFTR):
1080
CFTR
[′ACATTTTGTGTTTATGTTATTTGCARTGTTT

c.3140 − 26A > G

TCTATGGAAATATTTCACAG′]

4262
NM_000570.4(FCGR3B):
2215
FCGR3B
[′GCTCGAGGCCTGGCTTGAGATGAGGYTCT

Gc.194A > (p.Asn65Ser)

CATTGTGAAACCACTGTGTGGA′]

4263
NM_198253.2(TERT): c.2705A > G
7015
TERT
[′TATGGCTGCGTGGTGAACTTGCGGARGAC

(p.Lys902Arg)

AGTGGTGAACTTCCCTGTAGAA′]

4264
NM_005022.3(PFN1): c.350A > G
5216
PFN1
[′GTTGATCAAACCACCGTGGACACCTYCTTT

(p.Glu117Gly)

GCCCATCAGCAGGACTAGCGC′]

4265
NM_005349.3(RBPJ): c.188A > G
3516
RBPJ
[′GTTGCACAGAAGTCATATGGAAATGRAAA

(p.Glu63Gly)

AAGGTAAGATTATTTTTCTGGT′]

4266
NM_005349.3(RBPJ): c.505A > G
3516
RBPJ
[′GATAAAAGTCATCTCCAAACCTTCCRAAA

(p.Lys169Glu)

AGAAGCAGTCATTGAAAAATGC′]

4267
NM_022787.3(NMNAT1):
64802
NMNAT1
[′GGTCATCCTGGCCCCTTTGCAGAGARACAC

c.817A > G (p.Asn273Asp)

TGCAGAAGCTAAGACATAGGA′]

4268
NM_020921.3(NIN): c.3665A > G
51199
NIN
[′CACAGAAACATCAAAAAGTAGGTCCYGTT

(p.Gln1222Arg)

TCTTTTCAGAAGCTCGATCACA′]

4269
NM_020921.3(NIN): c.5126A > G
51199
NIN
[′AAAATCTCTAGTGTTCTAAGCTACARCGAA

(p.Asn1709Ser)

AAACTGCTGAAAGAAAAGGAA′]

4270
NM_005340.6(HINT1): c.152A > G
3094
HINT1
[′GACATTTCCCCTCAAGCACCAACACRTTTT

(p.His51Arg)

CTGGTGATACCCAAGAAACAT′]

4271
NM_005050.3(ABCD4): c.956A > G
5826
ABCD4
[′GAGCTGGGTGAAGCAGCTGATGAGGYAGA

(p.Tyr319Cys)

TGCACACAAAGGCATTCTGGAC′]

4272
NM_000155.3(GALT): c.950A > G
2592
GALT
[′GCTGGGGCCAACTGGAACCATTGGCRGCT

(p.Gln317Arg)

GCACGCTCATTACTACCCTCCG′]

4273
NM_007294.3(BRCA1):
672
BRCA1
[′ACTTGCTGAGTGTGTTTCTCAAACARTTTA

c.213 − 12A > G

ATTTCAGGAGCCTACAAGAAA′]

4274
NM_007294.3(BRCA1):
672
BRCA1
[′GCAAAGCATGGATTCAAACTTAGGTRTTG

c.4096 + 3A> G

GAACCAGGTTTTTGTGTTTGCC′]

4275
NM_007294.3(BRCA1):
672
BRCA1
[′TGATGGGTTGTGTTTGGTTTCTTTCVGCAT

c.5194 − 2A > G

GATTTTGAAGTCAGAGGAGAT′]

4276
NM_007294.3(BRCA1):
672
BRCA1
[′GTGCAGCCAGATGCCTGGACAGAGGRCAA

c.5453A > G (p.Asp1818Gly)

TGGCTTCCATGGTAAGGTGCCT′]

4277
NM_000059.3(BRCA2):
675
BRCA2
[′TATGCTATACATGATGAAACATCTTRTAAA

c.1799A > G (p.Tyr600Cys)

GGAAAAAAAATACCGAAAGAC′]

4278
NM_000059.3(BRCA2):
675
BRCA2
[′ACAATTTTCCCCTTTTTTTACCCCCRGTGGT

c.476 − 2A > G

ATGTGGGAGTTTGTTTCATA′]

4279
NM_000059.3(BRCA2):
675
BRCA2
[′AAAGTGGCCATTATTGAACTTACAGNTGG

c.8168A > G (p.Asp2723Gly)

GTGGTATGCTGTTAAGGCCCAG′]

4280
NM_000059.3(BRCA2):
675
BRCA2
[′GAATTAATAATCCTTTTGTTTTCTTDGAAA

c.8633 − 2A > G

ACACAACAAAACCATATTTAC′]

4281
NM_000060.3(BTD): c.629A > G
686
BTD
[′AATAATGGAACCCTTGTTGACCGCTRCCGT

(p.Tyr210Cys)

AAACACAACCTCTACTTTGAG′]

4282
NM_000060.3(BTD): c.968A > G
686
BTD
[′ACCCCTCTGGAGTCCTTTTGGTACCRTGAC

(p.His323Arg)

ATGGAAAATCCCAAAAGTCAC′]

4283
NM_000155.3(GALT): c.857A > G
2592
GALT
[′ATCATGAAGAAGCTCTTGACCAAGTRTGA

(p.Tyr286Cys)

CAACCTCTTTGAGACGTCCTTT′]

4284
NM_000060.3(BTD): c.128A > G
686
BTD
[′TGTTACGTGGTTGCCCTGGGAGCCCRCACC

(p.His43Arg)

GGGGAGGAGAGCGTGGCTGAC′]

4285
NM_002437.4(MPV17): c.262A > G
4358
MPV17
[′CACCACCAAAGTGGATGCACTGAAGRAGA

(p.Lys88Glu)

TGTTGTTGGATCAGGTGAGCAG′]

4286
NM_002769.4(PRSS1): c.65A > G
−1
—
[′GTTGCTGCCCCCTTTGATGATGATGRCAAG

(p.Asp22Gly)

ATCGTTGGGGGCTACAACTGT′]

4287
NM_005211.3(CSF1R):
1436
CSF1R
[′GACTAACCCTGCAGTGCTTTCCCTCRGTGC

2c.2320 − A > G

ATCCACCGGGACGTGGCAGCG′]

4288
NM_024312.4(GNPTAB):
79158
GNPTAB
[′GAAAACGTTTCTTTTTCTTTGTTCTRGGTG

c.118 − 2A > G

GTTCTGGAATGGAGCCGAGAT′]

4289
NM_000495.4(COL4A5):
1287
COL4A5
[′AAATATTATATATCACATATTTTCARCAGG

c.3107 − 4A > G

GCCTCAGGGTGTGGAAGGGCC′]

4290
NM_000282.3(PCCA): c.862A > G
5095
PCCA
[′TGGGAATGCTTTATGGCTTAATGAANGAG

(p.Arg288Gly)

AGTGCTCAATTCAGAGAAGAAA′]

4291
NM_000288.3(PEX7): c.854A > G
5191
PEX7
[′TCTCTTCTTGAAACAGTGGAGCATCRTACA

(p.His285Arg)

GAGTTTACTTGTGGTTTAGAC′]

4292
NM_000532.4(PCCB): c.1606A > G
5096
PCCB
[′ACAACGTCCTTGGAGAAAACATGCARATA

(p.Asn536Asp)

TTCCATTGTAAACAAATCAAAG′]

4293
NM_000553.4(WRN):
7486
WRN
[′TCAAAGGAAAAATACATTTAAGATTVTAA

c.2089 − 3024A > G

GTCTGGTTATAAGCTTAAAAAG′]

4294
NM_001039958.1(MESP2):
145873
MESP2
[′GCGGCAGAGCGCCAGCGAGCGGGAGRAA

c.271A > G (p.Lys91Glu)

CTGCGCATGCGCACGCTGGCCCG′]

4295
NM_001099274.1(TINF2):
26277
TINF2
[′TAGGGGAGGCCATAAGGAGCGCCCCRCAG

c.850A > G (p.Thr284Ala)

TCATGCTGTTTCCCTTTAGGAA′]

4296
NM_001099274.1(TINF2):
26277
TINF2
[′CCCCACAGTCATGCTGTTTCCCTTTRGGAA

c.871A > G (p.Arg291Gly)

TCTCGGCTCACCAACCCAGGT′]

4297
NM_001363.4(DKC1): c.115A > G
1736
DKC1
[′ACAACACGCTGAAGAATTTCTTATCRAACC

(p.Lys39Glu)

TGAATCCAAAGTTGCTAAGTT′]

4298
NM_001363.4(DKC1): c.127A > G
1736
DKC1
[′AGAATTTCTTATCAAACCTGAATCCRAAGT

(p.Lys43Glu)

TGCTAAGTTGGACACGTCTCA′]

4299
NM_001363.4(DKC1): c.196A > G
1736
DKC1
[′GAATTTTGATAAGCTGAATGTAAGGRCAA

(p.Thr66Ala)

CACACTATACACCTCTTGCATG′]

4300
NM_001363.4(DKC1): c.941A > G
1736
DKC1
[′GTAAATGCCATCTGCTATGGGGCCARGATT

(p.Lys314Arg)

ATGCTTCCAGGTGTTCTTCGA′]

4301
NM_004614.4(TK2): c.173A > G
7084
TK2
[′GCATGTCGTCTTCCCACTTGCAATAYTGCC

(p.Asn58Ser)

CTCGACACAGATCTGGCAAAA′]

4302
NM_004614.4(TK2): c.278A > G
7084
TK2
[′AACCAACAACCCACTCACCAGAGGAYTGT

(p.Asn93Ser)

GGCCACGGACATTTCTCCACTT′]

4303
NM_004614.4(TK2): c.562A > G
7084
TK2
[′AGTTTACCTTCGGACCAATCCTGAGRCTTG

(p.Thr188Ala)

TTACCAGAGGTTAAAGAAGAG′]

4304
NM_024312.4(GNPTAB):
79158
GNPTAB
[′TTTATTTTCTCTTTGGTTTTATCGTRGGTTT

c.1285 − 2A > G

ATTTGACATGGCCTGTGCCA′]

4305
NM_024312.4(GNPTAB):
79158
GNPTAB
[′TTCACATCGCGGAAAGTCCCTGCTCRCATG

c.2867A > G (p.His956Arg)

CCTCACATGATTGACCGGATT′]

4306
NM_024312.4(GNPTAB):
79158
GNPTAB
[′AGGAAGTTTGTTTGCCTGAATGACARCATT

c.3458A > G (p.Asn1153Ser)

GACCACAATCATAAAGATGCT′]

4307
NM_024312.4(GNPTAB):
79158
GNPTAB
[′AGCAAAAATACTGGGAGGCAACTAARAGA

c.2783A > G (p.Lys928Arg)

TACATTTGCAGATTCCCTCAGA′]

4308
NM_198253.2(TERT): c.2537A > G
7015
TERT
[′TCCACGCTGCTCTGCAGCCTGTGCTRCGGC

(p.Tyr846Cys)

GACATGGAGAACAAGCTGTTT′]

4309
NM_198578.3(LRRK2):
120892
LRRK2
[′TAGAGAAACTGGAGCAGCTCATTTTRGAA

c.3342A > G (p.Leu1114=)

GGGTAAGAAAGAGCTCATTAAA′]

4310
NM_198578.3(LRRK2):
120892
LRRK2
[′TTTGGCTGACCTGCCTAGAAATATTRTGTT

c.5605A > G (p.Met1869Val)

GAATAATGATGAGTTGGAATT′]

4311
NM_207352.3(CYP4V2):
285440
CYP4V2
[′TTCAAAGCAAATTGACAAATCCTCTRTGTA

c.367A > G (p.Met123Val)

CAAGTTTTTAGAACCATGGCT′]

4312
NM_207352.3(CYP4V2):
285440
CYP4V2
[′CTTATGTTTAAAGAAGGATGGGAACRCAA

c.761A > G (p.His254Arg)

AAAGAGCCTTCAGATCCTACAT′]

4313
NR_001566.1(TERC): n.37A > G
7012
TERC
[′GGTGGGCCTGGGAGGGGTGGTGGCCDTTT

TTTGTCTAACCCTAACTGAGAA′]

4314
NR_001566.1(TERC): n.48A > G
7012
TERC
[′GAGGGGTGGTGGCCATTTTTTGTCTRACCC

TAACTGAGAAGGGCGTAGGCG′]

4315
NM_007171.3(POMT1): c.430A > G
10585
POMT1
[′CATGTGTTTCCTCTTTGAAACAGAGRATGC

(p.Asn144Asp)

TCTCATCACTCAGTCAAGGCT′]

4316
NM_003863.3(DPM2): c.68A > G
8818
DPM2
[′GCCGTTAGCCTGATCATCTTCACCTRCTAC

(p.Tyr23Cys)

ACCGCCTGGGTGATTCTCTTG′]

4317
NM_000030.2(AGXT): c.1020A > G
189
AGXT
[′GGAGAGACATCGTCAGCTACGTCATRGAC

(p.Ile340Met)

CACTTCGACATTGAGATCATGG′]

4318
NM_031418.2(ANO3): c.2053A > G
63982
ANO3
[′TTATGTTCTATTTCAGTGTCATCCTRGTGG

(p.Ser685Gly)

CTGTTTGATAGACCTCTGCCT′]

4319
NM_183075.2(CYP2U1):
113612
CYP2U1
[′CCTTTTTACATAGAAAAGGTTCATGRAGAA

c.1139A > G (p.Glu380Gly)

ATTGAAAGAGTCATTGGCGCC′]

4320
NM_003094.3(SNRPE): c.1A > G
6635
SNRPE
[′GGTGTGCTCTTTGTGAAATTCCACCRTGGC

(p.Met1Val)

GTACCGTGGCCAGGGTCAGAA′]

4321
NM_000344.3(SMN1): c.389A > G
6606
SMN1
[′ACCTGTGTTGTGGTTTACACTGGATRTGGA

(p.Tyr130Cys)

AATAGAGAGGAGCAAAATCTG′]

4322
NM_012082.3(ZFPM2):
−1
—
[′CATGCAGAGAACCATGCGCACACGCRAGC

c.2209A > G (p.Lys737Glu)

GCAGAAAGATGTATGAGATGTG′]

4323
NM_006364.2(SEC23A):
10484
SEC23A
[′TGTTCAGTGTCAATGTATCTTGGCAYTGGA

Gc.2104A > G (p.Met702Val)

AATCTGGAGTGAAGAATTTCC′]

4324
NM_001139.2(ALOX12B):
242
ALOX12B
[′ACCCTCCACGGCTGCGTCACTCGGGYAAT

c.1562A > G (p.Tyr521Cys)

AATAGGTGATGATCTCCGTCAC′]

4325
NM_001004434.2(SLC30A2):
7780
SLC30A2
[′GTGACTGTCAGGACCCTTCTGAGCAYGGC

c.161A > G (p.His54Arg)

AGTGATGGTTGCTCTGGGCAGC′]

4326
NM_001168272.1(ITPR1):
3708
ITPR1
[′CACTATCACTGCCCTGCTCCACAATRATCG

c.1759A > G (p.Asn587Asp)

GAAACTCCTGGAAAAACACAT′]

4327
m.15923A > G
−1
—
[′ATAAACTAATACACCAGTCTTGTAARCCG

GAGATGAAAACCTTTTTCCAAG′]

4328
NM_007332.2(TRPA1)
−1
—
[′TTTTTTTACTTTTCTAGATTTGAAARTTGTG

c.2564A > G (p.Asn855Ser)

GAATTTTTATTGTTATGTTG′]

4329
NM_014254.2(TMEM5):
10329
TMEM5
[′CCGGTCGGAGTAAACACAGAATGCTRTCG

c.1016A > G (p.Tyr339Cys)

AATCTATGAGGCTTGCTCCTAT′]

4330
NM_144577.3(CCDC114):
93233
CCDC114
[′ACTGATTTTTTTCTCCTCCCCCCACRGGAG

c.487 − 2A > G

ATCCACCACCTGCATCACCTG′]

4331
NM_000834.3(GRIN2B):
2904
GRIN2B
[′GGATTTGTTTGCTTTTTTCCTGTACRGGAA

c.2172 − 2A > G

ACTGGATGCCTTCATCTATGA′]

4332
NM_018486.2(HDAC8): c.539A > G
55869
HDAC8
[′ATTCTCTACGTGGATTTGGATCTGCRCCAT

(p.His180Arg)

GGAGATGGTAAGCCCTTTGGT′]

4333
NM_018486.2(HDAC8):
55869
HDAC8
[′ACACTATCCTCTGAGATCCCAGATCRTGAG

c.1001A > G (p.His334Arg)

GTAAGTAAGGCTCTGACAAGT′]

4334
NM_178012.4(TUBB2B):
347733
TUBB2B
[′GCAGACCTGCGCAAGCTGGCGGTGARCAT

c.767A > G (p.Asn256Ser)

GGTGCCCTTCCCTCGCCTGCAC′]

4335
NM_006888.4(CALM1): c.293A > G
801
CALM1
[′ATTGCTGAATGTTCACAGGATGGCARTGGT

(p.Asn98Ser)

TATATCAGTGCAGCAGAACTA′]

4336
NM_172107.2(KCNQ2):
3785
KCNQ2
[′GCCCCACCCACCCCCCTGCAGTGTCRTGCG

c.1636A > G (p.Met546Val)

GTTCCTGGTGTCCAAGCGGAA′]

4337
NM_001866.2(COX7B):
1349
COX7B
[′TGTATTCTTTTTTCGTTTTCCTGTARGTTCG

c.41 − 2A > G

AAGCATTCAGCAAACAATGG′]

4338
NM_001099922.2(ALG13):
79868
ALG13
[′TGAACAATCATCAGCTGGAACTGGCRAAG

c.339A > G (p.Ala113=)

CAGCTACACAAAGAGGGTCATC′]

4339
NM_001083614.1(EARS2):
124454
EARS2
[′CCCCATCAGGTATGACAATCGGTGCRGGA

c.502A > G (p.Arg168Gly)

ACATGAGCCAGGAGCAGGTGGC′]

4340
NM_001083614.1(EARS2):
124454
EARS2
[′TGCCTTGTACAACTACATCTTTGCTRAGAA

c.193A > G (p.Lys65Glu)

GTACCAGGGGAGCTTCATCCT′]

4341
NM_033109.4(PNPT1):
87178
PNPT1
[′ACCCTTCATGGATCAGCATTATTTCRAAGA

c.1160A > G (p.Gln387Arg)

GGACAAACACAGGTAATTTAT′]

4342
NM_033109.4(PNPT1):
87178
PNPT1
[′CCTTTCACCATAAGAGTTACATCTGRAGTC

c.1424A > G (p.Glu475Gly)

CTAGAGTCAAATGGTATGGTA′]

4343
NM_000390.2(CHM): c.1520A > G
1121
CHM
[′ATTTTTTTTTTAACAGATTTGGTTCRTTTGA

(p.His507Arg)

CTTGCACATCTTCTAAAACA′]

4344
NM_181690.2(AKT3): c.686A > G
10000
AKT3
[′TTGTGTTTTGTGATGGAATATGTTARTGGG

(p.Asn229Ser)

GGCGAGGTGAGTCAAGAAGTA′]

4345
NM_006567.3(FARS2): c.431A > G
10667
FARS2
[′CCCAGCAGGAAGAAGGGGGACAACTRTTA

(p.Tyr144Cys)

CCTGAATCGGACTCACATGCTG′]

4346
NM_001410.2(MEGF8):
1954
MEGF8
[′CAAGTGCCGGGAATCATTTCACGGGRGTC

c.7099A > G (p.Ser2367Gly)

CGCTGGGCGGCCAGCAGTGCTA′]

4347
NM_003124.4(SPR):
6697
SPR
[′CCTCATCGTCTCCTTTTCATCCTCTRGGTCC

c.596 − 2A > G

TCTGGACACAGACATGCAGC′]

4348
NM_005609.2(PYGM): c.152A > G
5837
PYGM
[′GACCGCAATGTGGCCACCCCACGAGRCTA

(p.Asp51Gly)

CTACTTTGCTCTGGCCCATACC′]

4349
NM_004247.3(EFTUD2):
9343
EFTUD2
[′TTACTTAGTATTTGCTTTTCAGGACRTGTG

Gc.623A > (p.His208Arg)

AATTTCTCTGATGAGGTCACA′]

4350
NM_001310338.1(MGME1):
92667
MGME1
[′GCTGTTCAACATGAAACCTTAAACTRTATA

c.743A > G (p.Tyr248Cys)

GGTCTGCTGGACTGTGTGGCT′]

4351
NM_001128085.1(ASPA):
−1
—
[′AAGAAAGACGTTTTTGATTTTTTTCRGACT

c.433 − 2A > G

TCTCTGGCTCCACTACCCTGC′]

4352
NM_000108.4(DLD): c.1444A > G
1738
DLD
[′TGGAGCATCCTGTGAAGATATAGCTRGAG

(p.Arg482Gly)

TCTGTCATGCACATCCGGTAAT′]

4353
NM_007215.3(POLG2):
11232
POLG2
[′ACTAACATTAAGAACAAACAAACCCNTAT

c.1105A > G (p.Arg369Gly)

TTTTAGTTTCCCAAGTCTATCT′]

4354
NM_004333.4(BRAF): c.2126A > G
673
BRAF
[′AGAGATGAGAGACCACTCTTTCCCCRAGT

(p.Gln709Arg)

AAGTAAAAGCTTCATGCTATCC′]

4355
NM_004985.4(KRAS): c.65A > G
3845
KRAS
[′GTAGGCAAGAGTGCCTTGACGATACDGCT

(p.Gln22Arg)

AATTCAGAATCATTTTGTGGAC′]

4356
NM_004985.4(KRAS): c.458A > G
3845
KRAS
[′ACTTTTTATGTATTTCAGGGTGTTGDTGAT

(p.Asp153Gly)

GCCTTCTATACATTAGTTCGA′]

4357
NM_002834.3(PTPN11):
5781
PTPN11
[′TAGTAAAAGTAACCCTGGAGACTTCRCAC

c.124A > G (p.Thr42Ala)

TTTCCGTTAGGTAAGTTGGAAT′]

4358
NM_002834.3(PTPN11):
5781
PTPN11
[′AGCTGTCACCCACATCAAGATTCAGNACA

c.172A > G (p.Asn58Asp)

CTGGTGATTACTATGACCTGTA′]

4359
NM_002834.3(PTPN11):
5781
PTPN11
[′TTTCTTTCTTTCCAGACACTACAACRACAG

c.767A > G (p.Gln256Arg)

GAGTGCAAACTTCTCTACAGC′]

4360
NM_002834.3(PTPN11):
5781
PTPN11
[′CAAAAACAAAAATAGATATAAAAACRTCC

c.844A > G (p.Ile282Val)

TGCCCTGTAAGTATCAATATTC′]

4361
NM_002834.3(PTPN11):
5781
PTPN11
[′GATGGTGCGGTCTCAGAGGTCAGGGRTGG

c.1510A > G (p.Met504Val)

TCCAGACAGAAGCACAGTACCG′]

4362
NM_002880.3(RAF1): c.524A > G
5894
RAF1
[′ACTTGTGGCTACAAATTTCATGAGCRCTGT

(p.His175Arg)

AGCACCAAAGTACCTACTATG′]

4363
NM_002880.3(RAF1): c.1279A > G
5894
RAF1
[′AATTGTGACCCAGTGGTGCGAGGGCRGCA

(p.Ser427Gly)

GCCTCTACAAACACCTGCATGT′]

4364
NM_005633.3(SOS1): c.508A > G
6654
SOS1
[′TATTAAAGTGGCAATGTGTGCTGACRAGG

(p.Lys170Glu)

TAGGAAACTGAGCTTTTCTATT′]

4365
NM_030662.3(MAP2K2):
5605
MAP2K2
[′GCGGCTGGAAGCCTTTCTCACCCAGRAAG

c.181A > G (p.Lys61Glu)

CCAAGGTCGGCGAACTCAAAGA′]

4366
NM_024334.2(TMEM43):
79188
TMEM43
[′GGAGAATGAAGGAAGGCTGGTGCACRTCA

c.271A > G (p.Ile91Val)

TTGGCGCCTTACGGACATCCAA′]

4367
NM_000084.4(CLCN5):
1184
CLCN5
[′CTGATGGCTGCAGCCATGACAAGCARGTG

c.1637A > G (p.Lys546Arg)

GGTGGCAGATGCTCTTGGGCGG′]

4368
NM_000084.4(CLCN5): c.815A > G
1184
CLCN5
[′CCTTCTTTCTTCTAGGTCAGCTACTRTTTTC

(p.Tyr272Cys)

CCCTCAAAACATTGTGGCGT′]

4369
NM_000095.2(COMP): c.1760A > G
1311
COMP
[′GGCGTGGACTTCGAGGGCACGTTCCRTGT

(p.His587Arg)

GAACACGGTCACGGATGACGAC′]

4370
NM_000530.6(MPZ): c.389A > G
4359
MPZ
[′AATGGCACGTTCACTTGTGACGTCARAAA

(p.Lys130Arg)

CCCTCCAGACATAGTGGGCAAG′]

4371
NM_000530.6(MPZ): c.347A > G
4359
MPZ
[′AAGGATGGCTCCATTGTCATACACARCCTA

(p.Asn116Ser)

GACTACAGTGACAATGGCACG′]

4372
NM_003611.2(OFD1): c.260A > G
8481
OFD1
[′GCAGATCACTTACAAAGATGTGGCTDTGA

(p.Tyr87Cys)

ATATTCACTTTCTGTTTTCTTT′]

4373
NM_003611.2(OFD1): c.290A > G
8481
OFD1
[′TATTCACTTTCTGTTTTCTTTCCAGRAAGTG

(p.Glu97Gly)

GTTTGGCAAAAGAAAAGGTA′]

4374
NM_003611.2(OFD1):
8481
OFD1
[′TAAAAGTGAAATATTTTCTTTTAACRGGTT

c.382 − 2A > G

TCAGGATCTGATAAAGAAAAT′]

4375
NM_003977.3(AIP): c.721A > G
9049
AIP
[′GCTGCTGCTCAACTACTGCCAGTGCDAGCT

(p.Lys241Glu)

GGTGGTCGAGGAGTACTACGA′]

4376
NM_006158.4(NEFL): c.293A > G
4747
NEFL
[′GAGAAGGCGCAGCTCCAGGACCTCARTGA

(p.Asn98Ser)

CCGCTTCGCCAGCTTCATCGAG′]

4377
NM_024312.4(GNPTAB):
79158
GNPTAB
[′ATATCTCAAGTCTTTGATGAAGTTGRTACA

c.3053A > G (p.Asp1018Gly)

GATCAATCTGGTGTCTTGTCT′]

4378
NM_025137.3(SPG11):
80208
SPG11
[′TAAAGCTAACTTTTATTTTTCCTATRGAGA

c.1457 − 2A > G

ATGGACTCTCTCTGATTTTGT′]

4379
NM_025137.3(SPG11):
80208
SPG11
[′ACAAGAATCCATCCTTCTCCCCAGGRTAAG

c.2608A > G (p.Ile870Val)

TCCAGAAGGCAAGTGTGAGAG′]

4380
NM_025137.3(SPG11):
80208
SPG11
[′GAATGAAATTTTAGATAAGCTGGCCRGGT

c.2833A > G (p.Arg945Gly)

ATTATAACTGTTGAACTAATAC′]

4381
NM_025137.3(SPG11):
80208
SPG11
[′CAGTGAGGAGTATGGGCTGGTGGTARGTA

c.6477 + 4A > G

GCCCCCTCAACCCCAGTCTCCA′]

4382
NM_212472.2(PRKARIA):
5573
PRKARIA
[′ATTTTGCAAACTCGTAATTTCTTTCRGGAG

c.178 − 2A > G

GAGGCAAAACAGATTCAGAAT′]

4383
NM_006231.3(POLE):
5426
POLE
[′CCAGTTCAGCTACCTGGAACCAGGTRTGG

c.4444 + 3A > G

CCTGCACCAGCCGCCCATCATG′]

4384
NM_003156.3(STIM1): c.251A > G
6786
STIM1
[′GACGATGATGCCAATGGTGATGTGGRTGT

(p.Asp84Gly)

GGAAGAAAGTGATGAGGTGAGC′]

4385
NM_003156.3(STIM1): c.326A > G
6786
STIM1
[′CCAACAGTGAAACACAGCACCTTCCRTGG

(p.His 109Arg)

TGAGGATAAGCTCATCAGCGTG′]

4386
NM_001128425.1(MUTYH):
4595
MUTYH
[′GGCTAAGAGCTGTTCCTGCTCCACCYGAG

c.934 − 2A > G

AGGCACAGGGTTGAGTGTCATA′]

4387
NM_133499.2(SYN1): c.1699A > G
6853
SYN1
[′GGCGGAGCCGGGCCAGAGACGGATGYCTG

(p.Thr567Ala)

ACGGGTAGCCTGTGGGGGGCCC′]

4388
NM_021629.3(GNB4): c.265A > G
59345
GNB4
[′TATTTGGGATAGCTATACAACAAATRAGG

(p.Lys89Glu)

TAGAATTTCTTCATAATTCTTT′]

4389
NM_138425.3(C12orf57):
113246
C12orf57
[′CTGAACCTAGAGCTTCAGACGCCCTRTGGC

c.1A > G (p.Met1Val)

GTCCGCCTCGACCCAACCGGC′]

4390
NM_000096.3(CP): c.2953A > G
1356
CP
[′GGGAGATGAAGTCAACTGGTATCTGRTGG

(p.Met985Val)

GAATGGGCAATGAAATAGACTT′]

4391
NM_000057.3(BLM):
641
BLM
[′AATATTAACAACATAATTATTTTATRGCTA

c.1088 − 2A > G

GACAGATAAGTTTACAGCAGC′]

4392
NM_000257.3(MYH7): c.5807A > G
4625
MYH7
[′TTTCAAAAGGGCTTGAATGAGGAGTRGCT

(p.Ter1936Trp)

TTGCCACATCTTGATCTGCTCA′]

4393
NM_152263.3(TPM3): c.505A > G
7170
TPM3
[′GGATCTTTTCCTGTAGGTGGCTCGTRAGTT

(p.Lys169Glu)

GGTGATCATTGAAGGAGACTT′]

4394
NM_152263.3(TPM3): c.733A > G
7170
TPM3
[′AGAGACCCGTGCTGAGTTTGCTGAGRGAT

(p.Arg245Gly)

CGGTAGCCAAGCTGGAAAAGAC′]

4395
NM_000096.3(CP):
1356
CP
[′GCATTAAACACTTTTTTCCCCCTGCRGTGA

c.1209 − 2A > G

CTCAGCGGTGTTTTTTGAACA′]

4396
NM_002739.3(PRKCG): c.76A > G
5582
PRKCG
[′CCTGTTTTGCAGAAAGGGGGCCCTGRGGC

(p.Arg26Gly)

AGAAGGTGGTCCACGAAGTCAA′]

4397
NM_000138.4(FBN1):
2200
FBN1
[′GTGTTTTGTTTTGTTGTGTTTTTCTRGAGGA

c.1148 − 2A > G

TTTCAACAAGCTGTGCTCTG′]

4398
NM_000138.4(FBN1): c.3058A > G
2200
FBN1
[′ACCCGGATTTGCCACAAAAGAAATTRCAA

(p.Thr1020Ala)

ATGGAAAGCCTTTCTTCAAAGG′]

4399
NM_000169.2(GLA): c.1153A > G
−1
—
[′GGCCTGTAATCCTGCCTGCTTCATCRCACA

(p.Thr385Ala)

GCTCCTCCCTGTGAAAAGGAA′]

4400
NM_000256.3(MYBPC3):
4607
MYBPC3
[′ACTTCAACGGCCCCTTCTGTTCTACRGCAA

c.1224 − 2A > G

GTAAGTTCCCCTCTGGATGGC′]

4401
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GTCAGCCTCGTCGGCAGGTGTGACGYCGT

c.1814A > G (p.Asp605Gly)

CAATGGTCAGTTTGTGGACCCT′]

4402
NM_000256.3(MYBPC3):
4607
MYBPC3
[′CTCTGAACTACATTGTGTCTTCTGCRGAAC

c.1928 − 2A > G

CTCCCAAGATCCACCTGGACT′]

4403
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GGGCCGCAGGTGCGTCTGGCACGTCBGGA

c.2309 − 2A > G

TGGGGTGGGATGGACCCACATC′]

4404
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GTGGCTTCTTGCTAAAAGCTGAGACYGAA

c.26 − 2A > G

GGGCCAGGTGGAGGCTACAGCG′]

4405
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GGCCACAGCCTAGACTGCGGGACACRGGG

c.927 − 2A > G

ACTCGAAGCTGGAGGCACCAGC′]

4406
NM_000257.3(MYH7): c.2206A > G
4625
MYH7
[′AGCGGCCATCCCTGAGGGACAGTTCRTTG

(p.Ile736Val)

ATAGCAGGAAGGGGGCAGAGAA′]

4407
NM_000257.3(MYH7): c.2681A > G
4625
MYH7
[′CTCCCCTCTGTTCCTCACCTTCAGGDACAA

(p.Glu894Gly)

GACAACCTGGCAGATGCTGAG′]

4408
NM_000260.3(MYO7A):
4647
MYO7A
[′CCTTACCCCATCCCTGTGCCCCTGCRGCTT

c.1344 − 2A > G

TGAGCAGCTCTGCATCAACTT′]

4409
NM_000260.3(MYO7A):
4647
MYO7A
[′GTGCCAGGGAAGGATCCCATGGCCGRTTC

c.6029A > G (p.Asp2010Gly)

CATCTTCCACTATTACCAGGTG′]

4410
NM_000260.3(MYO7A):
4647
MYO7A
[′CTCTCTATGCCCTTTCTGCTCCCCCRGGAT

c.6439 − 2A > G

ATCCTCACCACTCATCCCTTC′]

4411
NM_000441.1(SLC26A4):
−1
—
[′CCCTCCTCGCTGTCCTCTGGCTCGCRGGTC

c.−3 − 2A > G

ATGGCAGCGCCAGGCGGCAGG′]

4412
NM_000441.1(SLC26A4):
5172
SLC26A4
[′ATTACACCATCGATGGGAACCAGGTDTGG

c.1149 + 3A > G

GTGCCCTTTTGCTGAACTGGTT′]

4413
NM_000551.3(VHL): c.467A > G
7428
VHL
[′GATTTGGTTTTTGCCCTTCCAGTGTRTACTC

(p.Tyr156Cys)

TGAAAGAGCGATGCCTCCAG′]

4414
NM_002294.2(LAMP2):
3920
LAMP2
[′AAATATTATTTTTTTAAATGAATCCRGGAG

c.65 − 2A > G

CTGTGCGGTCTTATGCATTGG′]

4415
NM_004004.5(GJB2): c.1A > G
2706
GJB2
[′CAGAGCAAACCGCCCAGAGTAGAAGRTGG

(p.Met1Val)

ATTGGGGCACGCTGCAGACGAT′]

4416
NM_004004.5(GJB2): c.617A > G
2706
GJB2
[′GTGTCTGGAATTTGCATCCTGCTGARTGTC

(p.Asn206Ser)

ACTGAATTGTGTTATTTGCTA′]

4417
NM_033360.3(KRAS): c.182A > G
3845
KRAS
[′TTGGATATTCTCGACACAGCAGGTCNAGA

(p.Gln61Arg)

GGAGTACAGTGCAATGAGGGAC′]

4418
NM_006218.2(PIK3CA):
5290
PIK3CA
[′GATCCTCTCTCTGAAATCACTGAGCRGGAG

c.1637A > G (p.Gln546Arg)

AAAGATTTTCTATGGAGTCAC′]

4419
NM_006218.2(PIK3CA)
5290
PIK3CA
[′TGATGACATTGCATACATTCGAAAGRCCCT

c.3073A > G (p.Thr1025Ala)

AGCCTTAGATAAAACTGAGCA′]

4420
NM_032119.3(ADGRV1):
84059
ADGRV1
[′TTCTTCATGATTTAATTTTTTTCCCRGATCA

c.14973 − 2A > G

GGTTTCATTGTTGCTGAAAT′]

4421
NM_033056.3(PCDH15):
65217
PCDH15
[′TTATTTGTTTGTTTGTTTTGTCACTRGCACG

c.1998 − 2A > G

GGGATTCTAACCTTAGGGAA′]

4422
NM_138691.2(TMC1):
117531
TMC1
[′ATCTTCAACCAAGGCATGATCTGGTRGGCC

c.1763 + 3A > G

AGCTGTTGGACAGCTTATCAC′]

4423
NM_206933.2(USH2A):
7399
USH2A
[′CAACTTAACCTGTTAATTTTCTTACRGGGA

c.12067 − 2A > G

ACAAGCCATCAAGCCCACCTG′]

4424
NM_206933.2(USH2A):
7399
USH2A
[′CCCGTCACTGAAGATGTTGTATGTCYACAG

c.12295 − 2A > G

AAGGACAGAAGCAAAAGGGAT′]

4425
NM_206933.2(USH2A):
7399
USH2A
[′ATAATGCATAACCTTTCCCTGATGCRGGAA

c.1841 − 2A > G

GGAACTGTGAGCTGTGCAAGG′]

4426
NM_206933.2(USH2A):
7399
USH2A
[′GATGTTCCTGCTTGTCTTTTGCTTTRGATAT

c.8559 − 2A > G

GAGCTTCTGAGACGTAAAAT′]

4427
NM_032415.5(CARD11):
84433
CARD11
[′GGCCTCACGCACTTCCTGATGAACGRGGTC

c.401A > G (p.Glu134Gly)

ATCAAGCTGCAGCAGCAGATG′]

4428
NM_000548.3(TSC2):
7249
TSC2
[′CACCGCTGTCCCCTCTGCTGGTGACRGCAC

c.226 − 2A > G

GCAGTGGAAGCACTCTGGAAG′]

4429
NM_000548.3(TSC2):
7249
TSC2
[′TCATTGGCCTCCCTTGTGCCTGTGCRGGAG

c.1444 − 2A > G

GAGCTGATTAACTCAGTGGTC′]

4430
NM_000548.3(TSC2):
7249
TSC2
[′CCCTGACCACCCTCTCCATTACCGCDGCTC

c.2546 − 2A > G

TGGCCAGGCTGCCGCACCTCT′]

4431
NM_130466.3(UBE3B):
89910
UBE3B
[′TTTGTTCTCACTGTTTTCTTTCTTTRGGTGA

c.545 − 2A > G

AAGTCTTCGACCAGCGATGA′]

4432
NM_005430.3(WNT1):
7471
WNT1
[′CAACAACGAGGCAGGCCGTACGGTGRGCT

c.624 + 4A > G

TTGAGAGGCTCCGCACCCTAAG′]

4433
NM_001893.4(CSNK1D):
1453
CSNK1D
[′AAGCTTGAATGTGTCAAAACCAAACRCCC

c.137A > G (p.His46Arg)

TCAGCTCCACATTGAGAGCAAA′]

4434
NM_018972.2(GDAP1): c.368A > G
54332
GDAP1
[′AGCATGTATTACCCACGGGTACAACRTTAC

(p.His123Arg)

CGAGAGCTGCTTGACTCCTTG′]

4435
NM_032237.4(POMK): c.773A > G
84197
POMK
[′CATGGGGATTTCGTGGCTCCAGAGCRACT

(p.Gln258Arg)

GTGGCCCTATGGAGAGGACGTG′]

4436
NM_201647.2(STAMBP):
10617
STAMBP
[′CGTCGGTACTTCCGCTCTGGAGTTGRGATT

c.125A > G (p.Glu42Gly)

ATCCGAATGGCATCCATTTAC′]

4437
NM_001946.3(DUSP6): c.566A > G
1848
DUSP6
[′ACTACCATCCGAGTCTGTTGCACTAYTGGG

(p.Asn189Ser)

GTCTCGGTCAAGGTCAGACTC′]

4438
NM_003867.3(FGF17): c.560A > G
8822
FGF17
[′TACCAAGGCCAGCTGCCCTTCCCCARCCAC

(p.Asn187Ser)

GCCGAGAAGCAGAAGCAGTTC′]

4439
NM_013281.3(FLRT3):
−1
—
[′GGGCTCATGTGCCAAGCCCCAGAAARGGT

c.1016A > G (p.Lys339Arg)

TCGTGGGATGGCTATTAAGGAT′]

4440
NM_015560.2(OPA1): c.1146A > G
4976
OPA1
[′TTTTTATTTTTCCTGAGTAGACCATRTCCTT

(p.Ile382Met)

AAATGTAAAAGGCCCTGGAC′]

4441
NM_030964.3(SPRY4): c.530A > G
81848
SPRY4
[′CCGGCGGTCCCACCCGAGCTGGACARGCA

(p.Lys177Arg)

CTTCTTGCTGTGCGAGGCCTGT′]

4442
NM_002972.3(SBF1): c.1249A > G
6305
SBF1
[′AAGGCCATGCCCTCCAGCACCTTCAYCAG

(p.Met417Val)

GAAATCGTCCTCTACCAGCCCA′]

4443
NM_002972.3(SBF1): c.4768A > G
6305
SBF1
[′TACATGTAATTGTGGAACACAGGCGYCCT

(p.Thr1590Ala)

CTTGCTCAGCCGGTCCACATAC′]

4444
NM_006876.2(B4GAT1):
11041
B4GAT1
[′GTTCCATCCCCAAAAGGAGGCTGAARATC

c.1168A > G (p.Asn390Asp)

AGCACAATAAGATCCTATATCG′]

4445
NM_000059.3(BRCA2):
675
BRCA2
[′AAAATAAACTATTTTCTTTCCTCCCVGGGT

c.517 − 2A > G

CGTCAGACACCAAAACATATT′]

4446
NM_000059.3(BRCA2):
675
BRCA2
[′ATGTAATATAAAATAATTGTTTCCTRGGCA

c.6938 − 2A > G

CAATAAAAGATCGAAGATTGT′]

4447
NM_000059.3(BRCA2):
675
BRCA2
[′AACTTATATATTTTCTCCCCATTGCDGCAC

2c.7008 − A > G

AACTAAGGAACGTCAAGAGAT′]

4448
NM_000059.3(BRCA2):
675
BRCA2
[′GATAATATTCTACTTTTATTTGTTCRGGGC

c.7806 − 2A > G

TCTGTGTGACACTCCAGGTGT′]

4449
NM_000059.3(BRCA2):
675
BRCA2
[′AGCAGACCCAGCTTACCTTGAGGTGRGAG

c.8754 + 4A > G

AGTAAGAGGACATATAATGAGG′]

4450
NM_000059.3(BRCA2):
675
BRCA2
[′GTTGAATTTTTGTTTTGTTTTCTGTRGGTTT

c.9118 − 2A > G

CAGATGAAATTTTATTTCAG′]

4451
NM_000059.3(BRCA2):
675
BRCA2
[′TAGGCTACGTTTTCATTTTTTTATCRGATGT

c.9649 − 2A > G

CTTCTCCTAATTGTGAGATA′]

NM_000218.2(KCNQ1):
3784
KCNQ1
[]

c.1070A > G (p.Gln357Arg)

4452
NM_000218.2(KCNQ1):
3784
KCNQ1
[′AAGGTGCAGCAGAAGCAGAGGCAGARGC

Gc.1085A > (p.Lys362Arg)

ACTTCAACCGGCAGATCCCGGCG′]

4453
NM_000218.2(KCNQ1):
3784
KCNQ1
[′TCGACGCATGCAGTACTTTGTGGCCVAGA

c.1576A > G (p.Lys526Glu)

AGAAATTCCAGGTAAGCCCTGT′]

NM_000218.2(KCNQ1):
3784
KCNQ1

c.1756A > G (p.Asn586Asp)

4454
NM_000218.2(KCNQ1): c.332A > G
3784
KCNQ1
[′CGCACCCACGTCCAGGGCCGCGTCTRCAA

(p.Tyr111Cys)

CTTCCTCGAGCGTCCCACCGGC′]

NM_000218.2(KCNQ1): c.344A > G
3784
KCNQ1
[]

(p.Glu115Gly)

4455
NM_000218.2(KCNQ1): c.773A > G
3784
KCNQ1
[′CTCCTGGGCTCCGTGGTCTTCATCCVCCGC

(p.His258Arg)

CAGGTGGGTGGCCCGGGTTAG′]

4456
NM_000218.2(KCNQ1): c.944A > G
3784
KCNQ1
[′CAGGTCACAGTCACCACCATCGGCTNTGG

(p.Tyr315Cys)

GGACAAGGTGCCCCAGACGTGG′]

NM_000218.2(KCNQ1): c.964A > G
3784
KCNQ1
=

(p.Thr322Ala)

4457
NM_000492.3(CFTR):
1080
CFTR
[′CCTAATAATGATGGGTTTTATTTCCRGACT

c.1393 − 2A > G

TCACTTCTAATGGTGATTATG′]

4458
NM_000492.3(CFTR):
1080
CFTR
[′ACAGAAAAAGAAATATTTGAAAGGTVTGT

c.1766 + 3A > G

TCTTTGAATACCTTACTTATAA′]

4459
NM_000492.3(CFTR): c.1A > G
1080
CFTR
[′CAGGGACCCCAGCGCCCGAGAGACCRTGC

(p.Met1Val)

AGAGGTCGCCTCTGGAAAAGGC′]

4460
NM_000492.3(CFTR):
1080
CFTR
[′ACCAACATGTTTTCTTTGATCTTACDGTTG

c.2989 − 2A > G

TTATTAATTGTGATTGGAGCT′]

4461
NM_000492.3(CFTR):
1080
CFTR
[′ACAACCTGAACAAATTTGATGAAGTNTGT

c.579 + 3A > G

ACCTATTGATTTAATCTTTTAG′]

4462
NM_007294.3(BRCA1): c.122A > G
672
BRCA1
[′GAACCTGTCTCCACAAAGTGTGACCRCAT

(p.His41Arg)

ATTTTGCAAGTAAGTTTGAATG′]

4463
NM_007294.3(BRCA1): c.1A > G
672
BRCA1
[′TTAAAGTTCATTGGAACAGAAAGAARTGG

(p.Met1Val)

ATTTATCTGCTCTTCGCGTTGA′]

4464
NM_007294.3(BRCA1):
672
BRCA1
[′TGTAAGAATGATATAACCAAAAGGTRTAT

c.212 + 3A > G

AATTTGGTAATGATGCTAGGTT′]

4465
NM_007294.3(BRCA1):
672
BRCA1
[′TCTGAACCTCTGTTTTTGTTATTTAVGGTG

c.4097 − 2A > G

AAGCAGCATCTGGGTGTGAGA′]

4466
NM_007294.3(BRCA1):
672
BRCA1
[′GTTTTCTCCTTCCATTTATCTTTCTRGGTCA

c.4485 − 2A > G

TCCCCTTCTAAATGCCCATC′]

4467
NM_007294.3(BRCA1):
672
BRCA1
[′ATAATGGAATATTTGATTTAATTTCRGATG

c.4987 − 2A > G

CTCGTGTACAAGTTTGCCAGA′]

4468
NM_007294.3(BRCA1):
672
BRCA1
[′AACTAATCTAATTACTGAAGAGACTRCTCA

c.5053A > G (p.Thr1685Ala)

TGTTGTTATGAAAACAGGTAT′]

4469
NM_007294.3(BRCA1):
672
BRCA1
[′AATGCTCTTTCCTTCCTGGGGATCCDGGGT

c.5407 − 2A > G

GTCCACCCAATTGTGGTTGTG′]

4470
NM_000540.2(RYR1): c.97A > G
6261
RYR1
[′CGCTACCGTGCTCAAGGAGCAGCTCRAGC

(p.Lys33Glu)

TCTGCCTGGCCGCCGAGGGCTT′]

4471
NM_015250.3(BICD2):
23299
BICD2
[′CGGCAGCTGGCGGCTGCTGAGGACGRGAA

c.2321A > G (p.Glu774Gly)

GAAGACGCTGAACTCGCTGCTG′]

4472
NM_006012.2(CLPP):
8192
CLPP
[′CATCGTGTGCGTCATGGGCCCGGTGRGCG

c.270 + 4A > G

CCCCGCGCCGGGACCCTCCCCA′]

4473
NM_004656.3(BAP1): c.277A > G
8314
BAP1
[′AGGAGCACGCTCAGCAAGGCATGAGHTGC

(p.Thr93Ala)

ACAAGAGTTGGGTATCAGCTGT′]

4474
NM_004315.4(ASAH1):
427
ASAH1
[′AGGAATCATTGGATGTATATGAGTARGTA

c.965 + 4A > G

GGTTTGTTAAAGCAAAAGAAGT′]

4475
NM_000100.3(CSTB):
1476
CSTB
[′GCTTCGCTCACTCCGCTCTCTTCCCRGGTG

c.169 − 2A > G

CACGTCGGCGACGAGGACTTC′]

4476
NM_015268.3(DNAJC13):
23317
DNAJC13
[′TTAAAATCTAGGTATGAATTTTTCARTGAG

c.2564A > G (p.Asn855Ser)

CTTTATCATCGCTTCTTGCTC′]

4477
NM_001003722.1(GLE1):
2733
GLE1
[′CTTAAAAAAAAAAAAAAAAAAAAAARCCT

c.433 − 10A > G

TTTCAGGAGGGCCTGAGGCTAT′]

4478
NM_001142519.1(FAM111A):
63901
FAM111A
[′TTCCAGAAAATAGTTCACAACCCTGDTGTG

c.1583A > G (p.Asp528Gly)

ATTACCTATGACACTGAATTT′]

4479
NM_001142519.1(FAM111A):
63901
FAM111A
[′GCATAGAACAACGTTTGGGAAAGTARCAA

c.1012A > G (p.Thr338Ala)

AAAATTCTTCTTCGATTAAAGT′]

4480
NM_001927.3(DES):
1674
DES
[′CTGAGTGTGCGATGGACCCTGTTACRGAA

c.1289 − 2A > G

ACCAGCCCTGAGCAAAGGGGTT′]

4481
NM_014795.3(ZEB2): c.3134A > G
9839
ZEB2
[′AAACACAAGCACCACCTTATCGAGCRCTC

(p.His1045Arg)

AAGGCTTCACTCGGGCGAGAAG′]

4482
NM_002163.2(IRF8): c.322A > G
3394
IRF8
[′CCAACTGGACATTTCCGAGCCATACRAAG

(p.Lys108Glu)

TTTACCGAATTGTTCCTGAGGA′]

4483
NM_002163.2(IRF8): c.238A > G
3394
IRF8
[′CAAAGCTGAACCAGCCACTTGGAAGRCGA

(p.Thr80Ala)

GGTTACGCTGTGCTTTGAATAA′]

4484
NM_001287.5(CLCN7): c.296A > G
1186
CLCN7
[′TGTCCCGGCCTGCAGAGCTTGGACTRTGAC

(p.Tyr99Cys)

AACAGTGAGAACCAGCTGTTC′]

4485
NM_001127217.2(SMAD9):
4093
SMAD9
[′AGAGAAGGCAGTGGACTCTCTAGTGRAGA

c.127A > G (p.Lys43Glu)

AGTTAAAGAAGAAGAAGGGAGC′]

4486
NM_002246.2(KCNK3): c.575A > G
3777
KCNK3
[′TGGACCTTCTTCCAGGCCTACTACTRCTGC

(p.Tyr192Cys)

TTCATCACCCTCACCACCATC′]

4487
NM_080605.3(B3GALT6): c.1A > G
126792
B3GALT6
[′CGCCACGCCCGCCGCAGCAGCTTCAYGGC

(p.Met1Val)

GCCCGCGCCGGGCCGGCGGCCC′]

4488
NM_080605.3(B3GALT6):
126792
B3GALT6
[′CGGCGCTCGGCGGCGCGGGGCGCGCYGGC

c.193A > G (p.Ser65Gly)

CACCAGCACTGCCAGGAAGGCG′]

4489
NM_000388.3(CASR): c.85A > G
846
CASR
[′CGGGCCAGACCAGCGAGCCCAAAAGRAGG

(p.Lys29Glu)

GGGACATTATCCTTGGGGGGCT′]

4490
NM_003793.3(CTSF): c.962A > G
8722
CTSF
[′GGGACCCTGCTCTCCCTCTCTGAACRGGGT

(p.Gln321Arg)

GAGCATCTCGCTCTACTCCTC′]

4491
NM_003793.3(CTSF): c.692A > G
8722
CTSF
[′GAGATCACTGAACTTGGTGACTCCAYACT

(p.Tyr231Cys)

GAGCTGTGCCACGGTCCAGGGC′]

4492
NM_022114.3(PRDM16):
63976
PRDM16
[′GGCAGCCGGGCCCGTGCCAGCCAAARCGG

c.2447A > G (p.Asn816Ser)

CGGCGGGCGGGAGCCCCGCAAG′]

4493
NM_173551.4(ANKS6):
203286
ANKS6
[′GGGCAGCACTGGGATGCTCCAGGGCYGTC

c.1322A > G (p.Gln441Arg)

GGACCTTCGAGTGGGGCAGGGG′]

4494
NM_005689.2(ABCB6): c.508A > G
10058
ABCB6
[′GAACTTGGCCCTGGTGTCTTGGAACRGCCC

(p.Ser170Gly)

ACAGTGGTGGTGGGCAAGGGC′]

4495
NM_001070.4(TUBG1): c.275A > G
7283
TUBG1
[′AAGCTCTACAACCCAGAGAACATCTRCCT

(p.Tyr92Cys)

GTCGGAACATGGAGGAGGAGCT′]

4496
NM_001613.2(ACTA2): c.145A > G
59
ACTA2
[′ACCTTTTTAGGGGGTGATGGTGGGARTGG

(p.Met49Val)

GACAAAAAGACAGCTACGTGGG′]

4497
NM_031157.2(HNRNPA1):
3178
HNRNPA1
[′AGCTACAATGATTTTGGGAATTACARCAAT

c.956A > G (p.Asn319Ser)

CAGTCTTCAAATTTTGGACCC′]

4498
NM_020117.9(LARS): c.1118A > G
51520
LARS
[′CTTAATAGTTAGCATTGGGAGAACAYAGA

(p.Tyr373Cys)

TCACCTTGTATGATGTTAAAGG′]

4499
NM_001651.3(AQP5): c.367A > G
362
AQP5
[′CTAACCCGCTATCCCCTTGCAGCTCRACAA

(p.Asn123Asp)

CAACACAACGCAGGGCCAGGC′]

4500
m.13637A > G
4540
MT-ND5
[′ATAATTCTTCTCACCCTAACAGGTCRACCT

CGCTTCCCCACCCTTACTAAC′]

4501
NM_000081.3(LYST):
1130
LYST
[′GGGAAGGCTTCTGTTCAAGCGATCARTGTT

c.10127A > G (p.Asn3376Ser)

TTTCATCCTGCTGTAAGTGAC′]

4502
NM_000142.4(FGFR3):
2261
FGFR3
[′CCAGCAGTGGGGGCTCGCGGACGTGNAGG

c.2421A > G p.Ter807Trp)

GCCACTGGTCCCCAACAATGTG′]

4503
NM_000207.2(INS): c.*59A > G
−1
—
[′TCCTGCACCGAGAGAGATGGAATAARGCC

CTTGAACCAGCCCTGCTGTGCC′]

4504
NM_000370.3(TTPA): c.191A > G
7274
TTPA
[′CTGCGCGCCCGGGATTTCGATCTGGRCCTG

(p.Asp64Gly)

GCCTGGCGGGTAAGCGTGCGT′]

4505
NM_001006657.1(WDR35):
57539
WDR35
[′AAACCTTTACGTGTCAAGAAGCTCTRTGTA

c.2912A > G (p.Tyr971Cys)

CTGTCAGCCTTACTTATAGAG′]

4506
NM_004595.4(SMS): c.443A > G
6611
SMS
[′GTATATGACGAAGATTCACCTTATCRAAAT

(p.Gln148Arg)

ATAAAAATTCTACACTCGAAG′]

4507
NM_005259.2(MSTN): c.458A > G
−1
—
[′AAAATACAATACAATAAAGTAGTAARGGC

(p.Lys153Arg)

CCAACTATGGATATATTTGAGA′]

4508
NM_000784.3(CYP27A1):
1593
CYP27A1
[′TGGGCCCTGTACCACCTCTCAAAGGRCCCT

c.1061A > G (p.Asp354Gly)

GAGATCCAGGAGGCCTTGCAC′]

4509
NM_000784.3(CYP27A1):
1593
CYP27A1
[′TCACTCTATGCCACCTTCCTCCCCARGTGG

c.776A > G (p.Lys259Arg)

ACTCGCCCCGTGCTGCCTTTC′]

4510
NM_000540.2(RYR1):
6261
RYR1
[′ATCCCAACTATCGGGCGGCTGCGCARGAG

c.10100A > G (p.Lys3367Arg)

GGCAGGGAAGGTGGTGTCCGAG′]

4511
NM_000540.2(RYR1):
6261
RYR1
[′CTACCTGTACACCGTGGTGGCCTTCRACTT

c.14572A > G (p.Asn4858Asp)

CTTCCGCAAGTTCTACAACAA′]

4512
NM_000540.2(RYR1):
6261
RYR1
[′CGCGGGTGACGAATACGAGCTCTACRGGG

c.14740A > G (p.Arg4914Gly)

TGGTCTTCGACATCACCTTCTT′]

4513
NM_000540.2(RYR1):
6261
RYR1
[′GCCTTCAACTTCTTCCGCAAGTTCTRCAAC

c.14591A > G (p.Tyr4864Cys)

AAGAGCGAGGATGAGGATGAA′]

4514
NM_002336.2(LRP6): c.1298A > G
4040
LRP6
[′GATCGAATAGAAGTGACAAGGCTCARTGG

(p.Asn433Ser)

GACCATGAGGAAGATCTTGATT′]

4515
NM_001257235.1(ALG13):
79868
ALG13
[′GTTATAAACGAAAAGTTGATGAACARTCA

c.8A > G (p.Asn3Ser)

TCAGCTGGAACTGGCAAAGCAG′]

4516
NM_001015879.1(AURKC):
6795
AURKC
[′CAGGGTGACTTTTCTTTGCACCCACRGATA

c.379 − 2A > G

ATAGAGGAGTTGGCAGATGCC′]

4517
NM_012160.4(FBXL4):
26235
FBXL4
[′AATTGTACCAGGTTACAGCAGCTGGRCAT

c.1694A > G (p.Asp565Gly)

ATTAGGTAAGGTTACAATATAT′]

4518
NM_020988.2(GNAO1): c.521A > G
2775
GNA01
[′GCCGACTACCAGCCCACCGAGCAGGRCAT

(p.Asp174Gly)

CCTCCGAACCAGGGTCAAAACC′]

4519
NM_001927.3(DES): c.1024A > G
1674
DES
[′GACCTGGGTTCCCCCTCTCCTGCAGRACGA

(p.Asn342Asp)

TTCCCTGATGAGGCAGATGCG′]

4520
NM_001927.3(DES): c.1333A > G
1674
DES
[′GGGTTCTGAGGTCCATACCAAGAAGRCGG

(p.Thr445Ala)

TGATGATCAAGACCATCGAGAC′]

4521
NM_001927.3(DES):
1674
DES
[′TCCTTAAGAAAGTGCATGAAGAGGTRTAC

c.735 + 3A > G

CTTGGCCCCTCTTCCTGGGGTC′]

4522
NM_002055.4(GFAP): c.1097A > G
2670
GFAP
[′GCCCTGGACATCGAGATCGCCACCTRCAG

(p.Tyr366Cys)

GAAGCTGCTAGAGGGCGAGGAG′]

4523
NM_002055.4(GFAP): c.1112A > G
2670
GFAP
[′ATCGCCACCTACAGGAAGCTGCTAGDGGG

(p.Glu371Gly)

CGAGGAGAACCGGTGAGCCCTC′]

4524
NM_002055.4(GFAP): c.1121A > G
2670
GFAP
[′TACAGGAAGCTGCTAGAGGGCGAGGRGAA

(p.Glu374Gly)

CCGGTGAGCCCTCATCACAGCC′]

4525
NM_002055.4(GFAP): c.230A > G
2670
GFAP
[′GAGCGGGCAGAGATGATGGAGCTCARTGA

(p.Asn77Ser)

CCGCTTTGCCAGCTACATCGAG′]

4526
NM_002055.4(GFAP): c.770A > G
2670
GFAP
[′AACATGCATGAAGCCGAAGAGTGGTRCCG

(p.Tyr257Cys)

CTCCAAGGTAGCCCTGCCTGTG′]

4527
NM_002055.4(GFAP): c.835A > G
2670
GFAP
[′CAACGCGGAGCTGCTCCGCCAGGCCRAGC

(p.Lys279Glu)

ACGAAGCCAACGACTACCGGCG′]

4528
NM_005554.3(KRT6A): c.511A > G
3853
KRT6A
[′GGAGCGTGAACAGATCAAGACCCTCDACA

(p.Asn171Asp)

ACAAGTTTGCCTCCTTCATCGA′]

4529
NM_005554.3(KRT6A): c.512A > G
3853
KRT6A
[′GAGCGTGAACAGATCAAGACCCTCAVCAA

(p.Asn171Ser)

CAAGTTTGCCTCCTTCATCGAC′]

4530
NM_005557.3(KRT16): c.373A > G
3868
KRT16
[′TGAGAAGGTGACCATGCAGAACCTCRATG

(p.Asn125Asp)

ACCGCCTGGCCTCCTACCTGGA′]

4531
NM_170707.3(LMNA):
4000
LMNA
[′TTTTGGTTTCTGTGTCCTTCCTCCAVCCCTT

c.640 − 10A > G

CCAGGAGCTGCGTGAGACCA′]

NM_000218.2(KCNQ1): c.1061A >
3784
KCNQ1
[]

G (p.Lys354Arg)

NM_000218.2(KCNQ1): c.1138A >
3784
KCNQ1
[]

G (p.Arg380Gly)

NM_000218.2(KCNQ1): c.1193A >
3784
KCNQ1
[]

G (p.Lys398Arg)

NM_000218.2(KCNQ1): c.1640A >
3784
KCNQ1
[]

G (p.Gln547Arg)

NM_000218.2(KCNQ1): c.1669A >
3784
KCNQ1
[]

G (p.Lys557Glu)

NM_000218.2(KCNQ1): c.1705A >
3784
KCNQ1
[]

G (p.Lys569Glu)

NM_000218.2(KCNQ1): c.1793A >
3784
KCNQ1
[]

G (p.Lys598Arg)

NM_000218.2(KCNQ1): c.430A > G
3784
KCNQ1
[]

(p.Thr144Ala)

NM_000218.2(KCNQ1): c.440A > G
3784
KCNQ1
[]

(p.Gln147Arg)

NM_000218.2(KCNQ1): c.548A > G
3784
KCNQ1
[]

(p.Lys183Arg)

4532
NM_000218.2(KCNQ1): c.592A > G
3784
KCNQ1
[′GCGGCTGCGCTTTGCCCGGAAGCCCRTTTC

(p.Ile198Val)

CATCATCGGTGAGTCATGCCT′]

4533
NM_000218.2(KCNQ1): c.652A > G
3784
KCNQ1
[′CATGGTGGTCCTCTGCGTGGGCTCCRAGGG

(p.Lys218Glu)

GCAGGTGTTTGCCACGTCGGC′]

4534
NM_000218.2(KCNQ1): c.820A > G
3784
KCNQ1
[′CCTGTACATCGGCTTCCTGGGCCTCRTCTT

(p.Ile274Val)

CTCCTCGTACTTTGTGTACCT′]

NM_000218.2(KCNQ1): c.842A > G
3784
KCNQ1
[]

(p.Tyr281Cys)

NM_000218.2(KCNQ1): c.931A > G
3784
KCNQ1
[]

(p.Thr311Ala)

NM_000218.2(KCNQ1): c.950A > G
3784
KCNQ1
[]

(p.Asp317Gly)

NM_000238.3(KCNH2): c.1205A >
3757
KCNH2
[]

G (p.His402Arg)

NM_000238.3(KCNH2): c.1259A >
3757
KCNH2
[]

G (p.Tyr420Cys)

4535
NM_000238.3(KCNH2): c.1280A >
3757
KCNH2
[′ATCTACACGGCTGTCTTCACACCCTVCTCG

G (p.Tyr427Cys)

GCTGCCTTCCTGCTGAAGGAG′]

NM_000238.3(KCNH2): c.128A > G
3757
KCNH2
[]

(p.Tyr43Cys)

NM_000238.3(KCNH2): c.1424A >
3757
KCNH2
[]

G (p.Tyr475Cys)

4536
NM_000238.3(KCNH2): c.1478A >
3757
KCNH2
[′CACCCCGGCCGCATCGCCGTCCACTNCTTC

G (p.Tyr493Cys)

AAGGGCTGGTTCCTCATCGAC′]

NM_000238.3(KCNH2): c.1502A >
3757
KCNH2
[]

G (p.Asp501Gly)

4537
NM_000238.3(KCNH2): c.1685A >
3757
KCNH2
[′ATGTGCACCTTTGCGCTCATCGCGCVCTGG

G (p.His562Arg)

CTAGCCTGCATCTGGTACGCC′]

4538
NM_000238.3(KCNH2): c.1711A >
3757
KCNH2
[′CTGGCTAGCCTGCATCTGGTACGCCVTCGG

G (p.Ile571Val)

CAACATGGAGCAGCCACACAT′]

4539
NM_000238.3(KCNH2): c.1720A >
3757
KCNH2
[′CTGCATCTGGTACGCCATCGGCAACVTGG

G (p.Met574Val)

AGCAGCCACACATGGACTCACG′]

NM_000238.3(KCNH2): c.1724A >
3757
KCNH2
[]

G (p.Glu575Gly)

4540
NM_000238.3(KCNH2): c.173A > G
3757
KCNH2
[′GAGCTGTGCGGCTACTCGCGGGCCGVGGT

(p.Glu58Gly)

GATGCAGCGACCCTGCACCTGC′]

NM_000238.3(KCNH2): c.1747A >
3757
KCNH2
[]

G (p.Ile583Val)

NM_000238.3(KCNH2): c.1762A >
3757
KCNH2
[]

G (p.Asn588Asp)

NM_000238.3(KCNH2): c.1777A >
3757
KCNH2
[]

G (p.Ile593Val)

NM_000238.3(KCNH2): c.1783A >
3757
KCNH2
[]

G (p.Lys595Glu)

NM_000238.3(KCNH2): c.1790A >
3757
KCNH2
[]

G (p.Tyr597Cys)

NM_000238.3(KCNH2): c.1826A >
3757
KCNH2
[]

G (p.Asp609Gly)

NM_000238.3(KCNH2): c.1847A >
3757
KCNH2
[]

G (p.Tyr616Cys)

NM_000238.3(KCNH2): c.1885A >
3757
KCNH2
[]

G (p.Asn629Asp)

4541
NM_000238.3(KCNH2): c.1886A >
3757
KCNH2
[′AGCCTCACCAGTGTGGGCTTCGGCANCGT

G (p.Asn629Ser)

CTCTCCCAACACCAACTCAGAG′]

NM_000238.3(KCNH2): c.1897A >
3757
KCNH2
[]

G (p.Asn633Asp)

4542
NM_000238.3(KCNH2): c.1898A >
3757
KCNH2
[′GTGGGCTTCGGCAACGTCTCTCCCADCACC

G (p.Asn633Ser)

AACTCAGAGAAGATCTTCTCC′]

NM_000238.3(KCNH2): c.1903A >
3757
KCNH2
[]

G (p.Asn635Asp)

NM_000238.3(KCNH2): c.1910A >
3757
KCNH2
[]

G (p.Glu637Gly)

NM_000238.3(KCNH2): c.1912A >
3757
KCNH2
[]

G (p.Lys638Glu)

4543
NM_000238.3(KCNH2): c.1933A >
3757
KCNH2
[′AGAGAAGATCTTCTCCATCTGCGTCDTGCT

G (p.Met645Val)

CATTGGCTGTGAGTGTGCCCA′]

NM_000238.3(KCNH2): c.209A > G
3757
KCNH2
[]

(p.His70Arg)

4544
NM_000238.3(KCNH2): c.2131A >
3757
KCNH2
[′GCACGCCTGGTCCTACACCAACGGCRTCG

G (p.Ile711Val)

ACATGAACGCGGTGAGGCCACC′]

NM_000238.3(KCNH2): c.2266A >
3757
KCNH2
[]

G (p.Met756Val)

NM_000238.3(KCNH2): c.2510A >
3757
KCNH2
[]

G (p.Asp837Gly)

NM_000238.3(KCNH2): c.2591A >
3757
KCNH2
[]

G (p.Asp864Gly)

NM_000238.3(KCNH2): c.286A > G
3757
KCNH2
[]

(p.Ile96Val)

4545
NM_000238.3(KCNH2): c.301A > G
3757
KCNH2
[′CAAAGTGGAAATCGCCTTCTACCGGDAAG

(p.Lys101Glu)

ATGGTAGGAGCGGGCCGGGGCG′]

4546
NM_000238.3(KCNH2): c.3118A >
3757
KCNH2
[′TCGGCGGCCCCGGGGCGACGTGGAGRGCA

G (p.Ser1040Gly)

GGCTGGATGCCCTCCAGCGCCA′]

NM_000238.3(KCNH2): c.3233A >
3757
KCNH2
[]

G (p.Tyr1078Cys)

NM_000238.3(KCNH2): c.3343A >
3757
KCNH2
[]

G (p.Met1115Val)

NM_000238.3(KCNH2): c.652A > G
3757
KCNH2
[]

(p.Met218Val)

NM_000238.3(KCNH2): c.82A > G
3757
KCNH2
[]

(p.Lys28Glu)

NM_000891.2(KCNJ2): c.220A > G
3759
KCNJ2
[]

(p.Thr74Ala)

NM_000891.2(KCNJ2): c.223A > G
3759
KCNJ2
[]

(p.Thr75Ala)

NM_000891.2(KCNJ2): c.233A > G
3759
KCNJ2
[]

(p.Asp78Gly)

NM_000891.2(KCNJ2): c.574A > G
3759
KCNJ2
[]

(p.Thr192Ala)

4547
NM_000891.2(KCNJ2): c.913A > G
3759
KCNJ2
[′CATACTGGAAGGCATGGTGGAAGCCVCTG

(p.Thr305Ala)

CCATGACGACACAGTGCCGTAG′]

NM_172201.1(KCNE2): c.269A > G
9992
KCNE2
[]

(p.Glu90Gly)

4548
NM_172201.1(KCNE2): c.281A > G
9992
KCNE2
[′CAGTACATTGTAGAGGACTGGCAGGRAAA

(p.Glu94Gly)

GTACAAGAGCCAAATCTTGAAT′]

NM_000335.4(SCN5A): c.1217A > G
6331
SCN5A
[]

(p.Asn406Ser)

NM_000335.4(SCN5A): c.1502A > G
6331
SCN5A
[]

(p.Asp501Gly)

NM_000335.4(SCN5A): c.2249A > G
6331
SCN5A
[]

(p.Gln750Arg)

NM_198056.2(SCN5A): c.2527A > G
6331
SCN5A
[]

(p.Thr843Ala)

NM_000335.4(SCN5A): c.2780A > G
6331
SCN5A
[]

(p.Asn927Ser)

NM_000335.4(SCN5A): c.3164A > G
6331
SCN5A
[]

(p.Asp1055Gly)

NM_000335.4(SCN5A): c.343A > G
6331
SCN5A
[]

(p.Ser115Gly)

NM_000335.4(SCN5A): c.3755A > G
6331
SCN5A
[]

(p.Glu1252Gly)

4549
NM_000335.4(SCN5A): c.376A > G
6331
SCN5A
[′AAAGGATATGAGTGAACCAGAATCTYCAC

(p.Lys126Glu)

AGCCGCTCTCCGGATGGGGTGG′]

4550
NM_198056.2(SCN5A): c.4000A > G
6331
SCN5A
[′TGCCCTGGTGGGCGCCATCCCGTCCRTCAT

(p.Ile1334Val)

GAACGTCCTCCTCGTCTGCCT′]

NM_000335.4(SCN5A): c.4223A > G
6331
SCN5A
[]

(p.Tyr1408Cys)

NM_000335.4(SCN5A): c.4252A > G
6331
SCN5A
[]

(p.Lys1418Glu)

NM_000335.4(SCN5A): c.4291A > G
6331
SCN5A
[]

(p.Arg1431Gly)

NM_198056.2(SCN5A): c.4346A > G
6331
SCN5A
[]

(p.Tyr1449Cys)

NM_000335.4(SCN5A): c.4412A > G
6331
SCN5A
[]

(p.Asn1471Ser)

4551
NM_198056.2(SCN5A): c.4478A > G
6331
SCN5A
[′ATCTTCATGACAGAGGAGCAGAAGARGTA

(p.Lys1493Arg)

CTACAATGCCATGAAGAAGCTG′]

NM_000335.4(SCN5A): c.4489A > G
6331
SCN5A
[]

(p.Met1497Val)

NM_000335.4(SCN5A): c.4577A > G
6331
SCN5A
[]

(p.Lys1526Arg)

4552
NM_198056.2(SCN5A): c.4978A > G
6331
SCN5A
[′GATGTCCCTGCCTGCCCTCTTCAACRTCGG

(p.Ile1660Val)

GCTGCTGCTCTTCCTCGTCAT′]

NM_000335.4(SCN5A): c.5138A > G
6331
SCN5A
[]

(p.Asp1713Gly)

NM_000335.4(SCN5A): c.5161A > G
6331
SCN5A
[]

(p.Asn1721Asp)

NM_000335.4(SCN5A): c.5297A > G
6331
SCN5A
[]

(p.Tyr1766Cys)

NM_198056.2(SCN5A): c.5302A > G
6331
SCN5A
[]

(p.Ile1768Val)

NM_000335.4(SCN5A): c.5317A > G
6331
SCN5A
[]

(p.Asn1773Asp)

NM_000335.4(SCN5A): c.5318A > G
6331
SCN5A
[]

(p.Asn1773Ser)

NM_000335.4(SCN5A): c.5366A > G
6331
SCN5A
[]

(p.Asp1789Gly)

NM_000335.4(SCN5A): c.5402A > G
6331
SCN5A
[]

(p.Asp1801Gly)

NM_000335.4(SCN5A): c.5513A > G
6331
SCN5A
[]

(p.Asp1838Gly)

NM_198056.2(SCN5A): c.5726A > G
6331
SCN5A
[]

(p.Gln1909Arg)

4553
NM_000335.4(SCN5A): c.688A > G
6331
SCN5A
[′CCGAGTCCTCCGGGCCCTGAAAACTRTATC

(p.Ile230Val)

AGTCATTTCAGGTGAAAATCA′]

NM_000335.4(SCN5A): c.715A > G
6331
SCN5A
[]

(p.Ile239Val)

NM_000335.4(SCN5A): c.89A > G
6331
SCN5A
[]

(p.Glu30Gly)

4554
NM_000383.3(AIRE): c.254A > G
326
AIRE
[′TTCTGGAGGGTGCTGTTCAAGGACTRCAAC

(p.Tyr85Cys)

CTGGAGCGCTATGGCCGGCTG′]

4555
NM_006920.4(SCN1A): c.1876A > G
6323
SCN1A
[′ACGCAACAGCAACCTGAGTCAGACCRGTA

(p.Ser626Gly)

GGTCATCCCGGATGCTGGCAGT′]

4556
NM_006920.4(SCN1A): c.4352A > G
−1
—
[′GAAGAAAGTCTGTACATGTATCTTTRCTTT

(p.Tyr1451Cys)

GTTATTTTCATCATCTTTGGG′]

4557
NM_000165.4(GJA1): c.617A > G
2697
GJA1
[′TGTTTCCTCTCTCGCCCCACGGAGARAACC

(p.Lys206Arg)

ATCTTCATCATCTTCATGCTG′]

4558
NM_000833.4(GRIN2A):
2903
GRIN2A
[′AGCTGTGTCTTTGTGTTTGTGCTGCRGGTG

c.1123 − 2A > G

GGCAAGTGGGAGAACCATACG′]

4559
NC_000007.14: g.62535490A > G
−1
—
[′GGAGAGTTTTGAGGCCTGTGGTTGARATG

GAAATATCTTCACAGAAAAACT′]

4560
NM_004595.4(SMS): c.983A > G
6611
SMS
[′AATCTGACAGAAGCACTGTCGCTCTVTGA

(p.Tyr328Cys)

AGAACAGCTGGGGCGCCTGTAT′]

4561
NM_001256864.1(DNAJC6):
9829
DNAJC6
[′CAAGAGAGTGCCAACCTTCTGTTTCRGATA

c.801 − 2A > G

CCTGGGCTATATGTGTGACCT′]

4562
NM_001204316.1(PRLR):
5618
PRLR
[′GTCCAGGTTCGCTGCAAACCAGACCRTGG

c.635A > G (p.His212Arg)

ATACTGGAGTGCATGGAGTCCA′]

4563
NM_012243.2(SLC35A3):
23443
SLC35A3
[′TTGGCTTCAAGATTTTGTGCCAACCRGGTA

c.886A > G (p.Ser296Gly)

AAATGTTCTTTTCTATTTTTT′]

4564
NM_000179.2(MSH6):
2956
MSH6
[′AAAGACCTTTTCCTCCCTCATTCACRGGCT

c.3439 − 2A > G

GGCTTATTAGCTGTAATGGCC′]

4565
NM_000249.3(MLH1): c.113A > G
4292
MLH1
[′AATGCTATCAAAGAGATGATTGAGARCTG

(p.Asn38Ser)

GTACGGAGGGAGTCGAGCCGGG′]

4566
NM_000249.3(MLH1): c.122A > G
4292
MLH1
[′TTTTCTGTTTGATTTGCCAGTTTAGRTGCA

(p.Asp41Gly)

AAATCCACAAGTATTCAAGTG′]

4567
NM_000249.3(MLH1):
4292
MLH1
[′TTTTTGGTTTTATTTTTTGTTTTGCNGTTCT

c.1559 − 2A > G

CCGGGAGATGTTGCATAACC′]

4568
NM_000249.3(MLH1):
4292
MLH1
[′TTGAGGTATTGAATTTCTTTGGACCRGGTG

c.1990 − 2A > G

AATTGGGACGAAGAAAAGGAA′]

4569
NM_000249.3(MLH1):
4292
MLH1
[′TTTACTCATCTTTTTGGTATCTAACVGAAA

c.208 − 2A > G

GAAGATCTGGATATTGTATGT′]

4570
NM_000249.3(MLH1): c.544A > G
4292
MLH1
[′TGGGAAAATTTTGGAAGTTGTTGGCRGGT

(p.Arg182Gly)

ACAGTCCAAAATCTGGGAGTGG′]

4571
NM_000249.3(MLH1):
4292
MLH1
[′AAAATTTTGGAAGTTGTTGGCAGGTRCAGT

c.545 + 3A > G

CCAAAATCTGGGAGTGGGTCT′]

4572
NM_000249.3(MLH1):
4292
MLH1
[′TCTTACTCTTTTGTTTTTCTTTTCCVGGTAT

c.546 − 2A > G

TCAGTACACAATGCAGGCAT′]

4573
NM_000249.3(MLH1):
4292
MLH1
[′TTGTGTCTTCTGCTGTTTGTTTATCRGCAAG

c.589 − 2A > G

GAGAGACAGTAGCTGATGTT′]

4574
NM_000249.3(MLH1):
4292
MLH1
[′GATTTTTTTATATAGGTTATCGACABACCG

c.677 + 3A > G

ACTAACAGCATTTCCAAAGAT′]

4575
NM_000249.3(MLH1):
4292
MLH1
[′ACTGGTTGCTTTCTTTTTATTGTTTRGATCG

c.791 − 2A > G

TCTGGTAGAATCAACTTCCT′]

4576
NM_000249.3(MLH1): c.883A > G
4292
MLH1
[′AAACACACACCCATTCCTGTACCTCVGGTA

(p.Ser295Gly)

ATGTAGCACCAAACTCCTCAA′]

4577
NM_000249.3(MLH1):
4292
MLH1
[′CACACCCATTCCTGTACCTCAGGTARTGTA

c.884 + 4A > G

GCACCAAACTCCTCAACCAAG′]

4578
NM_000251.2(MSH2):
4436
MSH2
[′TTTGTTTGTTTTACTACTTTCTTTTVGGAAA

2c.1277 − A > G

ACACCAGAAATTATTGTTGG′]

4579
NM_000251.2(MSH2):
4436
MSH2
[′CTTTTTCTTTTCTTCTTGATTATCARGGCTT

c.1511 − 2A > G

GGACCCTGGCAAACAGATTA′]

4580
NM_000251.2(MSH2): c.1660A > G
4436
MSH2
[′GAAGAATGGTGTTAAATTTACCAACNGGT

(p.Ser554Gly)

TTGCAAGTCGTTATTATATTTT′]

4581
NM_000535.5(PMS2): c.1A > G
5395
PMS2
[′CCGAGGCGGATCGGGTGTTGCATCCDTGG

(p.Met1Val)

AGCGAGCTGAGAGCTCGAGGTG′]

4582
NM_000535.5(PMS2):
5395
PMS2
[′ATAAATATGTTTTCTTTTTTGCCTTRGAATG

c.989 − 2A > G

CGTTGATATCAATGTTACTC′]

4583
NM_000059.3(BRCA2):
675
BRCA2
[′TAAGGGATTTGCTTTGTTTTATTTTRGTCCT

c.426 − 2A > G

GTTGTTCTACAATGTACACA′]

4584
NM_024876.3(ADCK4): c.857A > G
79934
ADCK4
[′CAGCAGGAGCTGGCTTGGGAGTGTGRCTA

(p.Asp286Gly)

CCGTCGTGAGGCGGCTTGTGCC′]

4585
NM_006005.3(WFS1): c.1385A > G
7466
WFS1
[′TACACGCGCAGGGCCCTGGCCACCGRGGT

(p.Glu462Gly)

CACCGCCGGCCTGCTATCGCTG′]

4586
NM_000019.3(ACAT1): c.472A > G
38
ACAT1
[′GGCAGGTGGGATGGAGAGCATGTCCRATG

(p.Asn158Asp)

TTCCATATGTAATGAACAGAGG′]

4587
NM_000050.4(ASS1):
445
ASS1
[′TCCACCTGTGCTGTCTCTTTCCTGCRGCAA

c.496 − 2A > G

CACGGGATTCCCATCCCGGTC′]

4588
NM_000117.2(EMD):
2010
EMD
[′CCCACTTGCTCCCCTCTTTTGCCTCRGGGA

c.450 − 2A > G

ACGCCCCATGTACGGCCGGGA′]

4589
NM_000153.3(GALC): c.334A > G
2581
GALC
[′GCATAATGCATGTGGGAGGGCTCAGBGCC

(p.Thr112Ala)

GTCTGAATAGAGGAGAGCAAAA′]

4590
NM_000155.3(GALT):
2592
GALT
[′CCCCACTGTCTCTCTTCTTTCTGTCRGGGG

c.905 − 2A > G

CTCCCACAGGATCAGAGGCTG′]

4591
NM_000159.3(GCDH): c.542A > G
2639
GCDH
[′CTCCTGGGCTGCTTCGGGCTCACAGRGCCC

(p.Glu181Gly)

AACAGCGGAAGTGACCCCAGC′]

4592
NM_000169.2(GLA): c.509A > G
−1
—
[′TGGGGAGTAGATCTGCTAAAATTTGRTGGT

(p.Asp170Gly)

TGTTACTGTGACAGTTTGGAA′]

4593
NM_000169.2(GLA):
−1
—
[′TATTTTACCCATTGTTTTCTCATACRGGTTA

c.548 − 2A > G

TAAGCACATGTCCTTGGCCC′]

4594
NM_000169.2(GLA): c.647A > G
−1
—
[′TCATATCTGTTTTCACAGCCCAATTRTACA

(p.Tyr216Cys)

GAAATCCGACAGTACTGCAAT′]

4595
NM_000232.4(SGCB): c.1A > G
6443
SGCB
[′GCTCGGCGGCGGCGGGCGCGGGAAGRTGG

(p.Met1Val)

CGGCAGCGGCGGCGGCGGCTGC′]

4596
NM_000255.3(MUT):
4594
MUT
[′TAAAATTTTTCTTTGGGAAATTACCRGGTT

c.1445 − 2A > G

CTGAAGTAATTGTTGGAGTAA′]

4597
NM_000277.1(PAH): c.533A > G
5053
PAH
[′AGTGGGCAGCCCATCCCTCGAGTGGDATA

(p.Glu178Gly)

CATGGAGGAAGAAAAGAAAACA′]

4598
NM_000277.1(PAH): c.974A > G
5053
PAH
[′CAGATTGACTTTCCATTCCAGATTTRCTGG

(p.Tyr325Cys)

TTTACTGTGGAGTTTGGGCTC′]

4599
NM_000328.2(RPGR):
6103
RPGR
[′TGATTATTTCTTTTTCCCTCCTACCRGGAA

c.155 − 2A > G

ATAATAAACTTTACATGTTTG′]

4600
NM_000350.2(ABCA4):
24
ABCA4
[′ATTAACGTGGGTGTCTCATTGCCTCRGAGA

c.4540 − 2A > G

ACACAGCGCAGCACGGAAATT′]

4601
NM_000350.2(ABCA4):
24
ABCA4
[′TTCTCTCTTTTTGTTTTGTTTTTCCRGATTC

c.67 − 2A > G

GCTTTGTGGTGGAACTCGTG′]

4602
NM_000487.5(ARSA):
410
ARSA
[′CCCCGTGACCCCTGACTCTGCCCCCRGAGC

2c.1108 − A > G

CCTCGGCAGTCTCTCTTCTTC′]

4603
NM_000489.4(ATRX):
546
ATRX
[′TAATGTTCTTTATTTCTTCTTTTTTRGATAA

c.134 − 2A > G

AATCAGTGGTTCTGGAAGTA′]

4604
NM_000489.4(ATRX): c.536A > G
546
ATRX
[′TGCACTGCTTGTGGACAACAGGTCARTCAT

(p.Asn179Ser)

TTTCAAAAAGATTCCATTTAT′]

4605
NM_000512.4(GALNS):
2588
GALNS
[′CTTCTATTACCGTGGCGACACGCTGRTGGC

c.1171A > G (p.Met391Val)

GGCCACCCTCGGGCAGCACAA′]

4606
NM_000521.3(HEXB):
3074
HEXB
[′ATGTATTGCAATTTGTAACGTTAATRGCTT

c.1243 − 2A > G

GCGCCGGGCACAATAGTTGAA′]

4607
NM_000531.5(OTC): c.238A > G
5009
OTC
[′ATAGTATTTGCCTTTATTGCAAGGGRAGTC

(p.Lys80Glu)

CTTAGGCATGATTTTTGAGAA′]

4608
NM_000551.3(VHL): c.233A > G
7428
VHL
[′GAGCCCTCCCAGGTCATCTTCTGCARTCGC

(p.Asn78Ser)

AGTCCGCGCGTCGTGCTGCCC′]

4609
NM_001848.2(COL6A1):
1291
COL6A1
[′CCAACCTTGACCTGTTTTGTGTTCCRGGGA

c.805 − 2A > G

GAACGAGGCAAGCCGGGGCTC′]

4610
NM_001918.3(DBT):
1629
DBT
[′AATGAATAACAATTTAATGCTTTTCRGGCT

c.773 − 2A > G

TTCAAAAAGCAATGGTCAAGA′]

4611
NM_003482.3(KMT2D):
8085
KMT2D
[′TCAACAGTGTCCTTCATTCCCCCACRGAAC

c.5645 − 2A > G

TGCCCAAGATGGAATCCAAGG′]

4612
NM_003494.3(DYSF):
8291
DYSF
[′CAGGCCCTCTCTGCTCCCTTGCTCTRGGGA

c.1398 − 2A > G

CCGCCTGACTCACAATGACAT′]

4613
NM_004006.2(DMD):
1756
DMD
[′AAGAGGTCATAATAGGCTTCTTTCAVATTT

c.1332 − 9A > G

TCAGTTTACATAGAGTTTTAA′]

4614
NM_004006.2(DMD):
1756
DMD
[′AGTGGGATCACATGTGCCAACAGGTRTAG

c.3432 + 3A > G

ACAATCTCTTTCACTGTGGCTT′]

4615
NM_004006.2(DMD):
1756
DMD
[′AAACGTTGTTGCATTTGTCTGTTTCRGTTA

c.6763 − 2A > G

CTGGTGGAAGAGTTGCCCCTG′]

4616
NM_004006.2(DMD):
1756
DMD
[′AGCTGTGAATGCTTCATTCAGGCCCRAGTA

c.9224 + 61934A > G

AATATAGGAAGAGGTGTAGTG′]

4617
NM_004006.2(DMD):
1756
DMD
[′GCTGTGAATGCTTCATTCAGGCCCARGTAA

c.9225 − 647A > G

ATATAGGAAGAGGTGTAGTGG′]

4618
NM_004006.2(DMD):
1756
DMD
[′TGTTGCAATTTTCTTCTTCCTTTGTRGACCT

c.9650 − 2A > G

TTTCAAGCAAGTGGCAAGTT′]

4619
NM_015560.2(OPA1): c.983A > G
4976
OPA1
[′GAGATGATGACACGTTCTCCAGTTAVGGT

(p.Lys328Arg)

AAGAACATAGGCCGTCTCAGTG′]

4620
NM_144997.5(FLCN):
201163
FLCN
[′TTGCTCTGCCCCTGCCCTTCTCCCCRGTGG

2c.1433 − A > G

GCCCCACCATCCTGAATAAGA′]

4621
NM_144997.5(FLCN):
201163
FLCN
[′AGATTTACTTTTCCTTTTCATGGACRGGGC

c.250 − 2A > G

TGCCGGTCACTTGCTGCAGGG′]

4622
NM_000146.3(FTL): c.1A > G
2512
FTL
[′GTTAGCTCCTTCTTGCCAACCAACCRTGAG

(p.Met1Val)

CTCCCAGATTCGTCAGAATTA′]

4623
NM_024531.4(SLC52A2):
79581
SLC52A2
[′GTGCAGAGCTTTTCCTGCTTACCCTRCGGG

c.914A > G (p.Tyr305Cys)

CGTCTGGCCTACCACCTGGCT′]

4624
NM_001743.5(CALM2): c.293A > G
805
CALM2
[′TACTAAATTTTTTGCTAGGATGGCADTGGC

(p.Asn98Ser)

TATATTAGTGCTGCAGAACTT′]

4625
NM_014754.2(PTDSS1): c.1058A >
9791
PTDSS1
[′ACACAGTGCAAGCGCGTAGGAACACRATG

G (p.Gln353Arg)

CTGGGTGTTTGGGTGAGTAATC′]

4626
NM_052844.3(WDR34): c.1307A >
89891
WDR34
[′GGACCAGCGCACAGCAAACAGATACYTGA

G (p.Lys436Arg)

GGGAGAGCTGCAGCGAAGTCAA′]

4627
NM_001130010.2(C15orf41):
84529
C15orf41
[′TACTTCTGTTTTATAAAGGTGGACTVTGCG

c.281A > G (p.Tyr94Cys)

CCCTCATTAATGGCTCGGCTT′]

4628
NM_001290048.1(ATL3): c.521A >
25923
ATL3
[′AATTTCATCCATTGCCAGACGACCGYATTC

G (p.Tyr174Cys)

TGTGAAGAGCTTTAAAAAAGA′]

4629
NM_000531.5(OTC): c.1034A > G
5009
OTC
[′GTCATGGTGTCCCTGCTGACAGATTRCTCA

(p.Tyr345Cys)

CCTCAGCTCCAGAAGCCTAAA′]

4630
NM_000531.5(OTC): c.122A > G
5009
OTC
[′AATAAAGTGCAGCTGAAGGGCCGTGRCCT

(p.Asp41Gly)

TCTCACTCTAAAAAACTTTACC′]

4631
NM_000531.5(OTC): c.155A > G
5009
OTC
[′ACTCTAAAAAACTTTACCGGAGAAGRAAT

(p.Glu52Gly)

TAAATATATGCTATGGCTATCA′]

4632
NM_000531.5(OTC): c.1A > G
5009
OTC
[′TCGTCCTTTACACAATTAAAAGAAGDTGCT

(p.Met1Val)

GTTTAATCTGAGGATCCTGTT′]

4633
NM_000531.5(OTC): c.268A > G
5009
OTC
[′CTTAGGCATGATTTTTGAGAAAAGARGTA

(p.Ser90Gly)

CTCGAACAAGATTGTCTACAGA′]

4634
NM_000531.5(OTC): c.277A > G
5009
OTC
[′GATTTTTGAGAAAAGAAGTACTCGARCAA

(p.Thr93Ala)

GATTGTCTACAGAAACAGGTAA′]

4635
NM_000531.5(OTC): c.350A > G
5009
OTC
[′TGTTTTCTTACCACACAAGATATTCDTTTG

(p.His117Arg)

GGTGTGAATGAAAGTCTCACG′]

4636
NM_000531.5(OTC): c.377A > G
5009
OTC
[′TTGGGTGTGAATGAAAGTCTCACGGRCAC

(p.Asp126Gly)

GGCCCGGTTTGTAAATATTTTC′]

4637
NM_000531.5(OTC):
5009
OTC
[′GATTATCTTTTTCTTGGTTTGCCACNGTGT

c.387 − 2A > G

ATTGTCTAGCATGGCAGATGC′]

4638
NM_000531.5(OTC): c.481A > G
5009
OTC
[′TAAAGAAGCATCCATCCCAATTATCRATG

(p.Asn161Asp)

GGCTGTCAGATTTGTACCATCC′]

4639
NM_000531.5(OTC): c.482A > G
5009
OTC
[′AAAGAAGCATCCATCCCAATTATCARTGG

(p.Asn161Ser)

GCTGTCAGATTTGTACCATCCT′]

4640
NM_000531.5(OTC): c.503A > G
5009
OTC
[′ATCAATGGGCTGTCAGATTTGTACCVTCCT

(p.His168Arg)

ATCCAGATCCTGGCTGATTAC′]

4641
NM_000531.5(OTC): c.524A > G
5009
OTC
[′TACCATCCTATCCAGATCCTGGCTGDTTAC

(p.Asp175Gly)

CTCACGCTCCAGGTTGGTTTA′]

4642
NM_000531.5(OTC): c.527A > G
5009
OTC
[′CATCCTATCCAGATCCTGGCTGATTRCCTC

(p.Tyr176Cys)

ACGCTCCAGGTTGGTTTATTT′]

4643
NM_000531.5(OTC):
5009
OTC
[′TCATCTCCTTCATCCCGTGCCTTTTRGGAA

c.541 − 2A > G

CACTATAGCTCTCTGAAAGGT′]

4644
NM_000531.5(OTC): c.542A > G
5009
OTC
[′TCTCCTTCATCCCGTGCCTTTTAGGRACAC

(p.Glu181Gly)

TATAGCTCTCTGAAAGGTCTT′]

4645
NM_000531.5(OTC): c.548A > G
5009
OTC
[′TCATCCCGTGCCTTTTAGGAACACTRTAGC

(p.Tyr183Cys)

TCTCTGAAAGGTCTTACCCTC′]

4646
NM_000531.5(OTC): c.595A > G
5009
OTC
[′CCTCAGCTGGATCGGGGATGGGAACRATA

(p.Asn199Asp)

TCCTGCACTCCATCATGATGAG′]

4647
NM_000531.5(OTC): c.596A > G
5009
OTC
[′CTCAGCTGGATCGGGGATGGGAACARTAT

(p.Asn199Ser)

CCTGCACTCCATCATGATGAGC′]

4648
NM_000531.5(OTC): c.613A > G
5009
OTC
[′TGGGAACAATATCCTGCACTCCATCRTGAT

(p.Met205Val)

GAGCGCAGCGAAATTCGGAAT′]

4649
NM_000531.5(OTC): c.716A > G
5009
OTC
[′AAGTTGGCAGAGCAGTATGCCAAAGDGGT

(p.Glu239Gly)

ATGCTCTTTACATGTAAAGCTA′]

4650
NM_000531.5(OTC):
5009
OTC
[′TGGCAGAGCAGTATGCCAAAGAGGTRTGC

c.717 + 3A > G

TCTTTACATGTAAAGCTATTAT′]

4651
NM_000531.5(OTC):
5009
OTC
[′TTTAACCAGCGTGTTTATGTATGCTRGAAT

c.718 − 2A > G

GGTACCAAGCTGTTGCTGACA′]

4652
NM_000531.5(OTC): c.788A > G
5009
OTC
[′CATGGAGGCAATGTATTAATTACAGRCAC

(p.Asp263Gly)

TTGGATAAGCATGGGACAAGAA′]

4653
NM_000531.5(OTC): c.790A > G
5009
OTC
[′TGGAGGCAATGTATTAATTACAGACRCTTG

(p.Thr264Ala)

GATAAGCATGGGACAAGAAGA′]

4654
NM_000531.5(OTC): c.905A > G
5009
OTC
[′GCTGCCTCTGACTGGACATTTTTACDCTGC

(p.His302Arg)

TTGCCCAGAAAGCCAGAAGAA′]

4655
NM_000531.5(OTC): c.929A > G
5009
OTC
[′CACTGCTTGCCCAGAAAGCCAGAAGRAGT

(p.Glu310Gly)

GGATGATGAAGTCTTTTATTCT′]

4656
NM_000531.5(OTC): c.988A > G
5009
OTC
[′ACTAGTGTTCCCAGAGGCAGAAAACRGAA

(p.Arg330Gly)

AGTGGACAATCATGGTAAGCAA′]

4657
NM_000322.4(PRPH2): c.422A > G
5961
PRPH2
[′GGGCTCAAGAACGGCATGAAGTACTRCCG

(p.Tyr141Cys)

GGACACAGACACCCCTGGCAGG′]

NM_003590.4(CUL3):
8452
CUL3
[]

c.1207 − 26A > G

NM_003590.4(CUL3): c.1376A > G
8452
CUL3
[]

(p.Lys459Arg)

NM_003590.4(CUL3):
8452
CUL3
[]

c.1377 + 3A > G

4658
NM_017415.2(KLHL3): c.232A > G
26249
KLHL3
[′AGCCTGCAGCCCCTACTTCTGTGCGDTGTT

(p.Met78Val)

CACAGGTATGGTGAGTGGCCA′]

NM_017415.2(KLHL3): c.926A > G
26249
KLHL3
[]

(p.Gln309Arg)

4659
NM_005763.3(AASS): c.874A > G
10157
AASS
[′CTCACATCAGTATTAAAACGACTTAYGTA

(p.Ile292Val)

GCGCTCCGGATGTTTGTCATAC′]

4660
NM_000203.4(IDUA): c.1874A > G
3425
IDUA
[′TCCTACCGAGTTCGAGCCCTGGACTRCTGG

(p.Tyr625Cys)

GCCCGACCAGGCCCCTTCTCG′]

4661
NM_000546.5(TP53): c.736A > G
7157
TP53
[′GTGTAACAGTTCCTGCATGGGCGGCVTGA

(p.Met246Val)

ACCGGAGGCCCATCCTCACCAT′]

4662
NM_194442.2(LBR): c.1639A > G
3930
LBR
[′GCCATGATGAGATCACCCAAGTAATYGGG

(p.Asn547Asp)

GTGGCGAACAAAGCCCCACCAT′]

4663
NM_000090.3(COL3A1):
1281
COL3A1
[′ATTAAAAAATATTTTTATTTCCTCTRGGGT

c.2284 − 2A > G

CCTACTGGTCCTATTGGTCCT′]

(p.Gly762_Lys779del)

4664
NM_000090.3(COL3A1):
1281
COL3A1
[′TCTTGAAATTGTATTTAATTTTTTCRGGGC

c.997 − 2A > G

CCTCCTGGTCCTCCTGGAACT′]

(p.Gly333_Lys350del+)

4665
NM_000090.3(COL3A1):
1281
COL3A1
[′CATTGTGATGTCATGATACTTTCTTDGGGA

c.3418 − 2A > G

CCTGTTGGACCCAGTGGACCT′]

(p.Arg1139_Gly1140ins

VSSTERYYRSTCFRCLHFRKIFWHCDVMILSW)

4666
NM_000090.3(COL3A1):
1281
COL3A1
[′AAAAGAGCTCTTGAAATTGTATTTARTTTT

c.997 − 10A > G

TTCAGGGCCCTCCTGGTCCTC′]

(p.Pro332_Gly333insFFQ)

4667
NM_000090.3(COL3A1):
1281
COL3A1
[′ACAGAGTGTATCATTATACTTTTCTDGGGG

c.1870 − 2A > G

CCTGGTGGTGACAAAGGAGAC′]

(p.Gly624_Gln641del)

4668
NM_000090.3(COL3A1):
1281
COL3A1
[′CTTCTCAATTGAATGTTTTCATCTTRGGGC

2c.3202 − A > G

CCTGCTGGCCCTGCTGGTGCT′]

(p.Gly1068_Pro1085del)

4669
NM_000090.3(COL3A1):
1281
COL3A1
[′AGTAAATACCGACCACTTCTTCTTTRGGGT

2c.1762 − A > G

GCTCCTGGTAAGAATGGAGAA′]

(p.Gly588_Gln605del)

4670
NM_003611.2(OFD1):
8481
OFD1
[′CTTTTTGGCAATAATGAAAAGGTAARTTGA

c.935 + 706A > G

TCAAGAGAGAGGAAATAGGCA′]

4671
NM_014740.3(EIF4A3): c.809A > G
9775
EIF4A3
[′AGTGATGGTCAGTGTGTCGTAGAGGYCAC

(p.Asp270Gly)

ACAGAGTGTCAAATTTCCACTC′]

4672
NM_001040436.2(YARS2):
51067
YARS2
[′TTTGTTACTTGTTGGTGATTTATGCYGACT

c.1303A > G (p.Ser435Gly)

CCGCCTTCTGTTATCATTCGA′]

4673
NM_000277.1(PAH): c.1157A > G
5053
PAH
[′ACTGTCACGGAGTTCCAGCCCCTCTRTTAC

(p.Tyr386Cys)

GTGGCAGAGAGTTTTAATGAT′]

4674
NM_000277.1(PAH): c.812A > G
5053
PAH
[′TTCCACTGCACACAGTACATCAGACDTGG

(p.His271Arg)

ATCCAAGCCCATGTATACCCCC′]

4675
NM_004820.3(CYP7B1): c.889A > G
9420
CYP7B1
[′ATTGCCCAGAACATAGTTGGAATAGYGTT

(p.Thr297Ala)

TGCCACAGAGGCCCAGAGAAAG′]

4676
NM_024301.4(FKRP): c.1A > G
79147
FKRP
[′CCAGCTAGCCCCAGACTTCGGCCCCRTGCG

(p.Met1Val)

GCTCACCCGCTGCCAGGCTGC′]

4677
NM_001955.4(EDN1): c.271A > G
1906
EDN1
[′GTATGGACTTGGAAGCCCTAGGTCCRAGA

(p.Lys91Glu)

GAGCCTTGGAGAATTTACTTCC′]

4678
NM_198947.3(FAM111B):
374393
FAM111B
[′TAATGTATACTGTATGTTTACCCAARGAAG

c.1879A > G (p.Arg627Gly)

TTTCCTATCAGAGGTTTGGAA′]

4679
NM_001282227.1(CECR1):
51816
CECR1
[′GCCCATGAAGACCTCATAGAAATCAYAGG

c.1232A > G (p.Tyr411Cys)

ACAAGCCTTTGGCACCAAACAT′]

4680
NM_033419.4(PGAP3): c.914A > G
93210
PGAP3
[′TGATTCCTTCAGCAGGTACAGGCTGYCATC

(p.Asp305Gly)

TTCCAGAAAGCTGTGGGCCAA′]

4681
NM_007294.3(BRCA1):
672
BRCA1
[′TGTTCTTTCTTTCTTTATAATTTATRGATTT

c.135 − 2A > G

TGCATGCTGAAACTTCTCAA′]

4682
NM_007294.3(BRCA1):
672
BRCA1
[′AAATTAAACTTCTCCCATTCCTTTCRGAGG

c.4676 − 2A > G

GAACCCCTTACCTGGAATCTG′]

4683
NM_015474.3(SAMHD1):
25939
SAMHD1
[′GGAAATGACAATCAAGTTTCTTACAYTGT

c.1153A > G (p.Met385Val)

ATCAATAATGTTGCCAACTTTG′]

4684
NM_015474.3(SAMHD1):
25939
SAMHD1
[′TTTTGGAAGAGATTCATAGTCCTCCYGGAA

c.1411 − 2A > G

AACACAAGACTCCCCATGTTA′]

4685
NM_000097.5(CPOX): c.980A > G
1371
CPOX
[′ACCAATGCCCCGCCGTTCTCCACGAYGGG

(p.His327Arg)

CTATAAAGAAGTAATCATCACA′]

4686
NM_012338.3(TSPAN12): c.413A
23554
TSPAN12
[′AAGCCACCGATATCTAGGTAATCCAYAAT

G (p.Tyr138Cys)

TTGTCATCCTGGCTTTCAAAGT′]

4687
NM_000406.2(GNRHR): c.94A > G
2798
GNRHR
[′GTCACTCGGATCTTTCCAGACAAGGYCAG

(p.Thr32Ala)

AGTGGGGAGGTTGCCCTGCATC′]

4688
NM_199189.2(MATR3): c.1864A >
9782
MATR3
[′TGGTTCCCAGAAGACTGAGAGTTCARCCG

G (p.Thr622Ala)

AAGGTAAAGAACAAGAAGAGAA′]

4689
NM_003181.3(T): c.512A > G
6862
T
[′CTGTGGACCCCCAACTCTCACTATGYGGAT

(p.His171Arg)

TCGAGGCTCATACTTATGCAA′]

4690
NM_000321.2(RB1): c.1927A > G
5925
RB1
[′AGCCTTCCAGACCCAGAAGCCATTGRAAT

(p.Lys643Glu)

CTACCTCTCTTTCACTGTTTTA′]

4691
NM_002234.3(KCNA5): c.143A > G
3741
KCNA5
[′GCTGGGCTCAGCGATGGGCCCAAGGRGCC

(p.Glu48Gly)

GGCGCCAAAGGGGCGCGGCGCG′]

4692
NM_178014.3(TUBB): c.895A > G
203068
TUBB
[′CCAGCAGGTCTTCGATGCCAAGAACRTGA

(p.Met299Val)

TGGCTGCCTGTGACCCCCGCCA′]

4693
NM_000136.2(FANCC):
2176
FANCC
[′TGCTTCTATTTGTTCCCTTTCTTACRGATTT

c.−78 − 2A > G

AATGTGTGCCGACCATTTCC′]

4694
NM_000546.5(TP53): c.488A > G
7157
TP53
[′CTCCGTCATGTGCTGTGACTGCTTGYAGAT

(p.Tyr163Cys)

GGCCATGGCGCGGACGCGGGT′]

4695
NM_000546.5(TP53): c.659A > G
7157
TP53
[′TTTCGACATAGTGTGGTGGTGCCCTVTGAG

(p.Tyr220Cys)

CCGCCTGAGGTCTGGTTTGCA′]

4696
NM_000546.5(TP53): c.701A > G
7157
TP53
[′GGCTCTGACTGTACCACCATCCACTRCAAC

(p.Tyr234Cys)

TACATGTGTAACAGTTCCTGC′]

4697
NM_002878.3(RAD51D): c.1A > G
−1
—
[′CACAGTCCGACCCTGAGCACGCCCAYGTT

(p.Met1Val)

CCCCGCAGGCCGGAACAGCCCC′]

4698
NM_058216.2(RAD51C):
5889
RAD51C
[′ATCTAATATTATCTCTTCTGTATTTRGGTTC

c.706 − 2A > G

GACTAGTGATAGTGGATGGT′]

4699
NM_015713.4(RRM2B): c.556A > G
50484
RRM2B
[′TCTACAGCAGCAAAGGCCACCACTCYTTC

(p.Arg186Gly)

CCCTGGGAGACATAAAATCGTT′]

4700
NM_015713.4(RRM2B): c.581A > G
50484
RRM2B
[′AAAAGATCCTGAGAAGAAAACTCCTYCTA

(p.Glu194Gly)

CAGCAGCAAAGGCCACCACTCT′]

4701
NM_000219.5(KCNE1): c.242A > G
3753
KCNE1
[′CACTCGAACGACCCATTCAACGTCTDCATC

(p.Tyr81Cys)

GAGTCCGATGCCTGGCAAGAG′]

4702
NM_000271.4(NPC1): c.1832A > G
4864
NPC1
[′TTCACTGCTGAACGAAGTATTGAAGRTGA

(p.Asp611Gly)

ACTAAATCGTGAAAGTGACAGT′]

4703
NM_000257.3(MYH7): c.1952A > G
4625
MYH7
[′CTGGGGCTGTGTCCCACTCACCCTGYGCAG

(p.His651Arg)

AGCTGACACAGTCTGAAAGGA′]

4704
NM_000540.2(RYR1): c.7043A > G
6261
RYR1
[′GGGTGGCCAGGCGAGAGCGTGGAGGRGA

(p.Glu2348Gly)

ACGCCAATGTGGTGGTGCGGCTG′]

4705
NM_058216.2(RAD51C):
5889
RAD51C
[′TTTGTATATATATTTTTTATCTTTCRGCCTC

c.1027 − 2A > G

AGGGATTTAGAGATACTGTT′]

4706
NM_130838.1(UBE3A):
7337
UBE3A
[′TGTATTTTTAAAAATCATTTCTTATRGGTA

c.1694 − 2A > G

TGTTCACATACGATGAATCTA′]

4707
NM_022168.3(IFIH1): c.1009A > G
64135
IFIH1
[′TCCTTGGCAATGTAAACAGCCACTCYGGTT

(p.Arg337Gly)

TTTCCACTCCCTGTAGGGAGG′]

4708
NM_022068.3(PIEZO2): c.2134A >
63895
PIEZO2
[′GCCACACAGAACAGGAACAGCACCAYGTA

G (p.Met712Val)

GATGATTTTGTACATTACGATT′]

4709
NM_001164342.2(ZBTB20):
26137
ZBTB20
[′ACCGCCAAACAGAACTACGTCAAGCRCAT

c.1787A > G (p.His596Arg)

GTTCGTACACACAGGTGAGTGT′]

4710
NM_001128159.2(VPS53):
55275
VPS53
[′TGCCTGATACTACGTCCATCTCACCYGTTC

c.2084A > G (p.Gln695Arg)

TGCTCCCACCATGCTAATTGG′]

4711
NM_003108.3(SOX11): c.347A > G
6664
SOX11
[′AAGCACATGGCCGACTACCCCGACTRCAA

(p.Tyr116Cys)

GTACCGGCCCCGGAAAAAGCCC′]

4712
NM_020435.3(GJC2):
57165
GJC2
[′TTCAGACCCTGAGGCCGAGGGGGGARCAA

c.−170A > G

TGGGGCCCTTGAGGGCCCCTCC′]

4713
NM_004817.3(TJP2):
9414
TJP2
[′GATTTACTTCCCGTGGTTTCTTCTCRGAGC

c.1992 − 2A > G

TGAACAAATGGCCAGTGTTCA′]

4714
NM_017565.3(FAM20A):
−1
—
[′GGTGTCTCCTCATCTCGCTGCTGTCYGGAA

c.720 − 2A > G

GGAAGGAAGGAATCACGCCCT′]

4715
NM_002764.3(PRPS1): c.343A > G
5631
PRPS1
[′AATCTCAGCCAAGCTTGTTGCAAATRTGCT

(p.Met115Val)

ATCTGTAGCAGGTGCAGATCA′]

4716
NM_000216.2(ANOS1): c.1A > G
3730
ANOS1
[′TCGCCCTCGCCCTCGACCCGCAGCCRTGGT

(p.Met1Val)

GCCCGGGGTGCCCGGCGCGGT′]

4717
NM_031229.2(RBCK1): c.1160A >
10616
RBCK1
[′TGGTGCTTCTTTGAGGATGATGTCARTGAG

G (p.Asn387Ser)

TTCACCTGCCCTGTGTGTTTC′]

4718
NM_015599.2(PGM3): c.737A > G
5238
PGM3
[′CACAAAGTCAGCTCCACATAAATGAYTGA

(p.Asn246Ser)

GTTTGCCCTTGGACCCATCATT′]

4719
NM_015599.2(PGM3): c.1352A > G
5238
PGM3
[′TTTCTCTCACACCTGAACTTTAAGTYGTCT

(p.Gln451Arg)

GTTTGGAAGATCTGTATAGAG′]

4720
NM_000535.5(PMS2):
5395
PMS2
[′CTTTTCTACTCCTTGTATTTTGTGCRGGTCT

c.904 − 2A > G

GCAGACTCGTGAATGAGGTC′]

4721
NM_000546.5(TP53): c.358A > G
7157
TP53
[′GGGCTTCTTGCATTCTGGGACAGCCDAGTC

(p.Lys120Glu)

TGTGACTTGCACGGTCAGTTG′]

4722
NM_000546.5(TP53): c.842A > G
7157
TP53
[′CGTGTTTGTGCCTGTCCTGGGAGAGDCCGG

(p.Asp281Gly)

CGCACAGAGGAAGAGAATCTC′]

4723
NM_001128425.1(MUTYH):
4595
MUTYH
[′CCCCTGCCTGGCTGCCCTCCCTCTCRGGTC

c.1187 − 2A > G

TGCTGGCAGGACTGTGGGAGT′]

4724
NM_000546.5(TP53):
7157
TP53
[′TCTCCTCCCTGCTTCTGTCTCCTACRGCCAC

c.1101 − 2A > G

CTGAAGTCCAAAAAGGGTCA′]

4725
NM_000314.6(PTEN):
5728
PTEN
[′GGCTTCTCTTTTTTTTCTGTCCACCRGGGA

c.493 − 2A > G

GTAACTATTCCCAGTCAGAGG′]

4726
NM_000051.3(ATM):
472
ATM
[′ATATATTTTAATTTTGTGCCCTTGCRGATT

c.3994 − 2A > G

GATCACTTATTCATTAGTAAT′]

4727
NM_000314.6(PTEN): c.403A > G
5728
PTEN
[′TGGAAAGGGACGAACTGGTGTAATGRTAT

(p.Ile135Val)

GTGCATATTTATTACATCGGGG′]

4728
NM_000249.3(MLH1):
4292
MLH1
[′TAAATTATTTTCTGTTTGATTTGCCDGTTTA

c.117 − 2A > G

GATGCAAAATCCACAAGTAT′]

4729
NM_025150.4(TARS2):
80222
TARS2
[′GGTCCAACAGCAACAGTATATGGGTRAGA

c.695 + 3A > G

GTTGTCAAGATTAAGGCAAACA′]

4730
NM_206933.2(USH2A): c.10544A >
7399
USH2A
[′TGGACCAAAATAGACAATCTTGAAGVTAC

G (p.Asp3515Gly)

AATTGTCTTAAACTGGAGAAAA′]

4731
NM_000834.3(GRIN2B): c.1238A >
2904
GRIN2B
[′CATCTGAGCATTGTGACCCTGGAGGRGGC

G (p.Glu413Gly)

ACCATTTGTCATTGTGGAAAGT′]

4732
NM_004830.3(MED23): c.3638A >
9439
MED23
[′TGTAGCTATACGTTAGCTCTTGCACRTGCT

G (p.His1213Arg)

GTGTGGCACCATTCTAGCATC′]

4733
NM_003159.2(CDKL5): c.125A > G
6792
CDKL5
[′GAAACACATGAAATTGTGGCGATCARGAA

(p.Lys42Arg)

ATTCAAGGACAGTGAAGGTAGA′]

4734
NM_003159.2(CDKL5): c.380A > G
6792
CDKL5
[′CTAATCAAGGCTATTCACTGGTGCCRTAAG

(p.His127Arg)

AATGATATTGTCCATCGAGGT′]

4735
NM_003159.2(CDKL5): c.578A > G
6792
CDKL5
[′AGCGCTCCCTATGGAAAGTCCGTGGRCAT

(p.Asp193Gly)

GTGGTCGGTGGGCTGTATTCTT′]

4736
NM_198282.3(TMEM173):
340061
TMEM173
[′TGACCATGCCAGCCCATGGGCCACGYTGA

c.461A > G (p.Asn154Ser)

AATTCCCTTTTTCACACACTGC′]

4737
NM_032018.6(SPRTN): c.350A > G
83932
SPRTN
[′CTCCTGCATGAAATGATACATGCCTRTTTA

(p.Tyr117Cys)

TTTGTCACTAATAACGACAAA′]

4738
NM_001759.3(CCND2): c.838A > G
894
CCND2
[′GGAGGATGAACTGGACCAAGCCAGCRCCC

(p.Thr280Ala)

CTACAGACGTGCGGGATATCGA′]

4739
NM_007315.3(STAT1): c.854A > G
6772
STAT1
[′AGGGTCATGTTCGTAGGTGTATTTCYGTTC

(p.Gln285Arg)

CAATTCCTCCAACTTTTTAAG′]

4740
NM_139276.2(STAT3): c.1175A > G
6774
STAT3
[′GTTGGATTCTTCCATGTTCATCACTYTTGT

(p.Lys392Arg)

GTTTGTGCCCAGAATGTTAAA′]

4741
NM_001037811.2(HSD17B10):
3028
HSD17B10
[′GATGCCTGCACAGTTGACAGCTACAYCCA

7c.25A > G (p.Asp86Gly)

CACGGCCAAACTTTCCTTTTGC′]

4742
NM_005726.5(TSFM):
10102
TSFM
[′CGCGCGGACCGGGAGCTACCCGGTGRGAA

c.57 + 4A > G

GTCCTGGTGCTGGTACCGACCT′]

4743
NM_000166.5(GJB1): c.580A > G
2705
GJB1
[′CGAGAAAACCGTCTTCACCGTCTTCRTGCT

(p.Met194Val)

AGCTGCCTCTGGCATCTGCAT′]

4744
NM_001077494.3(NFKB2):
4791
NFKB2
[′TTACCCCCAGCAGAGGTGAAGGAAGRCAG

c.2594A > G (p.Asp865Gly)

TGCGTACGGGAGCCAGTCAGTG′]

4745
NC_012920.1: m.5559A > G
4578
MT-TW
[′TGTTACAGAAATTAAGTATTGCAACYTACT

GAGGGCTTTGAAGGCTCTTGG′]

4746
NC_012920.1: m.13514A > G
4540
MT-ND5
[′TTCCTCACAGGTTTCTACTCCAAAGRCCAC

ATCATCGAAACCGCAAACATA′]

4747
NM_007315.3(STAT1): c.2018A > G
6772
STAT1
[′GTAATACTTTCCAAAGGCATGGTCTYTGTC

(p.Lys673Arg)

AATATTTGGATACAGATACTT′]

4748
NM_007315.3(STAT1): c.1909A > G
6772
STAT1
[′GGGAAAGTAACAGCAGAAAGTTCTTYCTT

(p.Lys637Glu)

CGTGTAGGGTTCAACCGCATGG′]

4749
NM_000060.3(BTD): c.683A > G
686
BTD
[′GCATTCGATGTTCCTCTTAAAGTGGRTCTC

(p.Asp228Gly)

ATCACCTTTGATACCCCCTTT′]

4750
NM_004992.3(MECP2):
4204
MECP2
[′TACTTACATACTTGTTTAACACTTCRGGGA

c.27 − 2A > G

AGAAAAGTCAGAAGACCAGGA′]

4751
NM_004992.3(MECP2):
4204
MECP2
[′CTTGTGTCTTTCTGTTTGTCCCCACNGTCCC

c.378 − 2A > G

CAGGGAAAAGCCTTTCGCTC′]

4752
NM_003159.2(CDKL5):
6792
CDKL5
[′TTTCCTTCTGCTTCTTTTCCCTTGCRGGAAA

2c.100 − A > G

CACATGAAATTGTGGCGATC′]

4753
NM_003159.2(CDKL5):
6792
CDKL5
[′ACAACTTTGGACTTTGCTATCTTTCRGGTT

2c.464 − A > G

TTGCTCGTAATCTGTCAGAAGT

4754
NM_003159.2(CDKL5):
6792
CDKL5
[′GATATACTTCTTTTGTTTTTAACATRGAAA

c.978 − 2A > G

CCAAGCCGGCAAAAGTACTGC′]

4755
NM_032492.3(JAGN1): c.485A > G
84522
JAGN1
[′TTGGCAGTGCAAGTGCATGCCTGGCRGTTG

(p.Gln162Arg)

TACTACAGCAAGAAGCTCCTA′]

4756
NM_178517.3(PIGW): c.499A > G
284098
PIGW
[′AACTGAGCTCTATGGGACAGGAGCARTGG

(p.Met167Val)

ATTTTGGAGTAGGTGGCTTTGT′]

4757
NM_004387.3(NKX2-5): c.461A > G
1482
NKX2-5
[′TCGCAGGCGCAGGTCTATGAGCTGGRGCG

(p.Glu154Gly)

GCGCTTCAAGCAGCAGCGGTAC′]

4758
NM_005859.4(PURA): c.289A > G
5813
PURA
[′CGCCGAGGTGGGCGCGGGCGGCAACRAGA

(p.Lys97Glu)

GCCGCCTTACTCTCTCCATGTC′]

4759
NM_004046.5(ATP5A1): c.962A > G
498
ATP5A1
[′GCGGAGCAACAGAGACATCTGACGGHAAG

(p.Tyr321Cys)

CAACAGCCTATGGTACAGAATA′]

4760
NM_000038.5(APC):
324
APC
[′GATGACCCATATTCTGTTTCTTACTRGGAA

c.1744 − 2A > G

TCAACCCTCAAAAGCGTATTG′]

4761
NM_000751.2(CHRND): c.1319A >
1144
CHRND
[′TTCAATGAGCTGAAGCCAGCTGTGGWTGG

G (p.Asp440Gly)

GGCAAACTTCATTGTTAACCAC′]

4762
NM_130466.3(UBE3B): c.1A > G
89910
UBE3B
[′GCAGGGTTTGTGCAAGTTTGCAAACRTGTT

(p.Met1Val)

CACCCTGTCTCAGACCTCGAG′]

4763
NM_003159.2(CDKL5): c.211A > G
6792
CDKL5
[′AATGCTTCGGACTCTCAAGCAGGAARACA

(p.Asn71Asp)

TTGTGGAGTTGAAGGAAGCATT′]

4764
NM_003159.2(CDKL5):
6792
CDKL5
[′AATTTTTTTTTTATCTTGACACTCCRGATAT

c.404 − 2A > G

AAAACCAGAAAATCTCTTAA′]

4765
NM_003159.2(CDKL5): c.449A > G
6792
CDKL5
[′TTAATCAGCCACAATGATGTCCTAARACTG

(p.Lys150Arg)

TGTGACTTTGGTAAGTTAAAA′]

4766
NM_001813.2(CENPE): c.4063A > G
1062
CENPE
[′ACTTCAAGGGCTTCTTTTATCGTTTYAAGG

(p.Lys1355Glu)

TTGTCTCTTTCCTTGGTTAGA′]

4767
NM_023073.3(C5orf42):
65250
C5orf42
[′ATTTTACCAAATTTTTGTATTTGATRGATC

c.3290 − 2A > G

CCATTGAAGAGGAAGATGCAA′]

4768
NM_002977.3(SCN9A): c.2215A > G
−1
—
[′GTGTTTAAAACTATGCAAATGGTAAYTGC

(p.Ile739Val)

AAGATCTACAAAAGGATCCATT′]

4769
NM_002354.2(EPCAM):
4072
EPCAM
[′TATTAGTATTAATTTGTATTATTCANTTTTT

c.556 − 14A > G

TTCCCCAGTATGAGAATAAT′]

4770
NM_002354.2(EPCAM):
4072
EPCAM
[′TTAATACAGATTTTAAATTCTTTACRGTGC

c.492 − 2A > G

ACTTCAGAAGGAGATCACAAC′]

4771
NM_000053.3(ATP7B): c.122A > G
540
ATP7B
[′ATCCAGACCACCTTCATAGCCAACAYTGTC

(p.Asn41Ser)

AAAAGCAAAACTCTTCTTCAT′]

4772
NM_022455.4(NSD1):
64324
NSD1
[′ATGTGGGACATTATTTTTTCTTTGCRAGGG

c.4498 − 3A > G

AGAACTAATGCCTCACAGGAC′]

4773
NM_022455.4(NSD1):
64324
NSD1
[′TAAGTCAGGAGGTATTTCTTGTTCTRGGGT

c.5893 − 2A > G

GAATTTGTGAATGAGTATGTG′]

4774
NM_022455.4(NSD1): c.6059A > G
64324
NSD1
[′AAAGGAAACTATGCTCGGTTCATGARTCA

(p.Asn2020Ser)

TTGCTGCCAGCCCAACTGTGAA′]

4775
NM_022455.4(NSD1): c.6356A > G
64324
NSD1
[′GGTGAAATCACAAAGGAGCGAGAAGRTGA

(p.Asp2119Gly)

GTGTTTTAGTTGTGGGGATGCT′]

4776
NM_133433.3(NIPBL): c.737A > G
25836
NIPBL
[′AATCCTAGACATGGTTCAAGTGAGGRCTA

(p.Asp246Gly)

CCTACACATGGTGCACAGGCTA′]

4777
NM_133433.3(NIPBL):
25836
NIPBL
[′TGTTTTTTTCTCTTCATTTTTCTTTRGCTTG

2c.5428 − A > G

ATATGCAACGAGGTGTTCAT′]

4778
NM_005249.4(FOXG1): c.757A > G
2290
FOXG1
[′CCACTACGACGACCCGGGCAAGGGCRACT

(p.Asn253Asp)

ACTGGATGCTGGACCCGTCGAG′]

4779
NM_004380.2(CREBBP): c.4508A >
1387
CREBBP
[′AAGCCAAAACGACTGCAGGAGTGGTRCAA

G (p.Tyr1503Cys)

AAAGATGCTGGACAAGGCGTTT′]

4780
NM_004380.2(CREBBP):
1387
CREBBP
[′CTCACCTGCTCCTTCTGGACTTCCTRGGGC

2c.3983 − A > G

TGCAGACCACAAGACTGGGAA′]

4781
NM_001083962.1(TCF4):
6925
TCF4
[′TTTTTTTTTTCTCCTTATTGTTTTARGATCT

2c.991 − A > G

ATTCTCCAGATCACACTAAC′]

4782
NM_178151.2(DCX):
1641
DCX
[′TTAACTTTGTCTCTTCTCTTCTTATRGGACC

c.1027 − 2A > G

TGTACCTGCCTCTGTCCTTG′]

4783
NM_178151.2(DCX): c.607A > G
1641
DCX
[′TGTGCGTGTGCTTCTGAACAAGAAGRCAG

(p.Thr203Ala)

CCCACTCTTTTGAGCAAGTCCT′]

4784
NM_178151.2(DCX): c.538A > G
1641
DCX
[′GGAGAACAAGGACTTTGTGCGCCCCRAGC

(p.Lys180Glu)

TGGTTACCATCATCCGCAGTGG′]

4785
NM_178151.2(DCX): c.520A > G
1641
DCX
[′CAACAGTGCACAGGCCAGGGAGAACRAGG

(p.Lys174Glu)

ACTTTGTGCGCCCCAAGCTGGT′]

4786
NM_178151.2(DCX): c.451A > G
1641
DCX
[′CAATCCCAACTGGTCTGTCAACGTADAAA

(p.Lys151Glu)

CATCTGCCAATATGAAAGCCCC′]

4787
NM_178151.2(DCX): c.413A > G
1641
DCX
[′GACAACTTCTTTAAAAAGGTGGAGTRCAC

(p.Tyr138Cys)

CAAGAATGTCAATCCCAACTGG′]

4788
NM_000252.2(MTM1): c.301A > G
4534
MTM1
[′AATTGAAAAAATGGGAGGCGCGACARGTA

(p.Ser101Gly)

GAGGAGAAAATTCCTATGGTCT′]

4789
NM_000252.2(MTM1):
4534
MTM1
[′ACTGTCATACTTCTCCTTTGCCCCCRGGAC

c.343 − 2A > G

ATGAGAAACCTGAGGTTCGCT′]

4790
NM_000252.2(MTM1):
4534
MTM1
[′GACTTGAATTTCTTTTTTTCCTCACRGGGCT

c.529 − 2A > G

TGCCCAATCACCATTGGAGA′]

4791
NM_000252.2(MTM1): c.550A > G
4534
MTM1
[′ACAGGGCTTGCCCAATCACCATTGGRGAA

(p.Arg184Gly)

TAACTTTTATTAATAAGTGCTA′]

4792
NM_000252.2(MTM1): c.629A > G
4534
MTM1
[′TTGGTGGTTCCGTATCGTGCCTCAGRTGAT

(p.Asp210Gly)

GACCTCCGGAGAGTTGCAACT′]

4793
NM_000252.2(MTM1): c.1406A > G
4534
MTM1
[′CAATTTTTGATTATAATTTTGGATCRTCTGT

(p.His469Arg)

ATAGTTGCCGATTTGGTACT′]

4794
NM_003159.2(CDKL5): c.62A > G
6792
CDKL5
[′TTTGAGATCCTTGGGGTTGTAGGTGRAGGT

(p.Glu21Gly)

AAGTTGGAATTTTTGCGTTCC′]

4795
NM_006306.3(SMC1A): c.3254A >
8243
SMC1A
[′GTGGCTACCAACATTGATGAGATCTRTAA

G (p.Tyr1085Cys)

GGCCCTGTCCCGCAATAGCAGT′]

4796
NM_006306.3(SMC1A):
8243
SMC1A
[′CCTGCCACCATTCCCCTGTTTGCACRGGCT

c.616 − 2A > G

GACCGGTACCAGCGCCTGAAG′]

4797
NM_003937.2(KYNU): c.592A > G
8942
KYNU
[′GCCTAACTTGATTTAGGGGGAAGAARCCT

(p.Thr198Ala)

TAAGAATAGAGGATATCCTTGA′]

4798
NM_005343.2(HRAS): c.182A > G
−1
—
[′TTGGACATCCTGGATACCGCCGGCCNGGA

(p.Gln61Arg)

GGAGTACAGCGCCATGCGGGAC′]

4799
NM_012275.2(IL36RN): c.104A > G
26525
IL36RN
[′CTAGCTGGAGGGCTGCATGCAGGGARGGT

(p.Lys35Arg)

CATTAAAGGTTGGTGATGAAAC′]

4800
NM_152296.4(ATP1A3): c.2318A >
478
ATP1A3
[′TCCATTGCCTACACCCTGACCAGCADTATC

G (p.Asn773Ser)

CCGGAGATCACGCCCTTCCTG′]

4801
NM_000891.2(KCNJ2): c.953A > G
3759
KCNJ2
[′CAGTGCCGTAGCTCTTATCTAGCAARTGAA

(p.Asn318Ser)

ATCCTGTGGGGCCACCGCTAT′]

4802
NM_017909.3(RMND1): c.713A > G
55005
RMND1
[′TACACTTACAGTTTTGTCTTTCACAYTCCA

(p.Asn238Ser)

AAACACAGCAGCTCCTTCCCT′]

4803
NM_005154.4(USP8): c.2150A > G
9101
USP8
[′GAACCTTCCAAACTGAAGCGCTCCTDCTCC

(p.Tyr717Cys)

TCCCCAGATATAACCCAGGCT′]

4804
NM_014191.3(SCN8A): c.667A > G
6334
SCN8A
[′CAATGTTTCAGCTCTACGCACTTTCRGGGT

(p.Arg223Gly)

ACTGAGGGCTTTGAAAACTAT′]

4805
NM_021830.4(C10orf2): c.1754A >
56652
C10orf2
[′CCCCAGGCAAGCCAGGAAGCAGACARTGT

G (p.Asn585Ser)

TCTGATCCTGCAGGACAGGAAG′]

4806
NM_001164405.1(BHLHA9):
727857
BHLHA9
[′GTCCAAGGCGCGGCGCATGGCCGCCRACG

c.211A > G (p.Asn71Asp)

TGCGGGAGCGCAAGCGCATCCT′]

4807
NM_002887.3(RARS): c.5A > G
5917
RARS
[′GAGTGAGACGCTGATGGGAGGATGGRCGT

(p.Asp2Gly)

ACTGGTGTCTGAGTGCTCCGCG′]

4808
NM_002887.3(RARS): c.1A > G
5917
RARS
[′TGGCGAGTGAGACGCTGATGGGAGGRTGG

(p.Met1Val)

ACGTACTGGTGTCTGAGTGCTC′]

4809
NM_005861.3(STUB1): c.194A > G
10273
STUB1
[′CCGCTGGTGGCCGTGTATTACACCARCCGG

(p.Asn65Ser)

GCCTTGTGCTACCTGAAGATG′]

4810
NM_005211.3(CSF1R):
1436
CSF1R
[′ATGGGCATCCTCTGTCCTATCTCCCRGATA

2c.2655 − A > G

CAGCATCATGCAGGCCTGCTG′]

4811
NM_032228.5(FAR1): c.1094A > G
84188
FAR1
[′CATAAGGCCCCAGCATTCCTGTATGRTATC

(p.Asp365Gly)

TACCTCAGGATGACTGGAAGA′]

4812
NM_020461.3(TUBGCP6):
85378
TUBGCP6
[′GCCATCCCAGGCAGGCGAGTGTTGCYCTG

c.2546A > G (p.Glu849Gly)

CAGACCCAGAATCACAGCCTTG′]

4813
NM_014305.3(TGDS): c.269A > G
23483
TGDS
[′TTTGTGAAACTGCTTTTTGAAACAGRGAAA

(p.Glu90Gly)

ATAGATATAGTACTACATTTT′]

4814
NM_014305.3(TGDS): c.892A > G
23483
TGDS
[′TCTGTTTTGTTTTCCAAGACCCACCRATGA

(p.Asn298Asp)

CATGAGATACCCAATGAAGTC′]

4815
NM_000118.3(ENG):
2022
ENG
[′GCTCGACAGGATATTGACCACCGCCYGCG

c.1273 − 2A > G

GGGATAAAGCCAGGGAGCTGGT′]

4816
NM_005360.4(MAF): c.172A > G
4094
MAF
[′CATCGCCGGGGGCTCGCTGTCCTCCRCCCC

(p.Thr58Ala)

CATGAGCACGCCGTGCAGCTC′]

4817
NM_002238.3(KCNH1): c.1399A >
3756
KCNH1
[′ACCTCTAGCACTTCTCTATGCCACCRTCTT

G (p.Ile467Val)

CGGGAATGTGACGACTATTTT′]

4818
NM_172362.2(KCNH1): c.1508A >
3756
KCNH1
[′TTCGGGAATGTGACGACTATTTTCCRACAG

G (p.Gln503Arg)

ATGTATGCCAACACCAACAGA′]

4819
NM_003392.4(WNT5A): c.257A > G
7474
WNT5A
[′GGACAGAAGAAACTGTGCCACTTGTRTCA

(p.Tyr86Cys)

GGACCACATGCAGTACATCGGA′]

4820
NM_001199252.2(SGOL1): c.67A >
−1
—
[′GCCAAGTTTTTATTCCTTTTCTCTTYCATTC

G (p.Lys23Glu)

GCTTCTTTATGTCTTCAAGA′]

4821
NM_000256.3(MYBPC3):
4607
MYBPC3
[′ACTTAGCTACCCACTCTATACCCACRGAAC

c.2906 − 2A > G

GGCCACGGCTTCAGCTGCCCA′]

4822
NM_000256.3(MYBPC3):
4607
MYBPC3
[′GCTCAAGAATGGCCAGGAGATCCAGRTGA

c.1213A > G (p.Met405Val)

GCGGCAGGTGCAGCCTGGGGTG′]

4823
NM_005188.3(CBL):
867
CBL
[′TGTTACTATCTTTTGCTTCTTCTGCRGGAAT

c.1228 − 2A > G

CAGAAGGTCAGGGCTGTCCT′]

4824
NM_000257.3(MYH7): c.5326A > G
4625
MYH7
[′TTCTTCATGCGCTCCAGGTGGGCGCYGGTG

(p.Ser1776Gly)

TCCTGCTCCTTCTTCAGCTCC′]

4825
NM_000257.3(MYH7): c.2708A > G
4625
MYH7
[′CAAGACAACCTGGCAGATGCTGAGGRGCG

(p.Glu903Gly)

CTGTGATCAGCTGATCAAAAAC′]

4826
NM_000257.3(MYH7): c.1727A > G
4625
MYH7
[′AATATCAAGGGGAAGCCTGAAGCCCRCTT

(p.His576Arg)

CTCCCTGATCCACTATGCCGGC′]

4827
NM_000257.3(MYH7): c.1496A > G
4625
MYH7
[′CACCACATGTTTGTGCTGGAGCAGGRGGA

(p.Glu499Gly)

GTACAAGAAGGAGGGCATCGAG′]

4828
NM_000257.3(MYH7): c.2539A > G
4625
MYH7
[′GCTGCTGAAGAGTGCAGAAAGAGAGRAGG

(p.Lys847Glu)

AGATGGCCTCCATGAAGGAGGA′]

4829
NM_000257.3(MYH7): c.1954A > G
4625
MYH7
[′CTTTCAGACTGTGTCAGCTCTGCACRGGGT

(p.Arg652Gly)

GAGTGGGACACAGCCCCAGCC′]

4830
NM_000257.3(MYH7): c.1157A > G
4625
MYH7
[′CTTCCAGAGGCTGACAAGTCTGCCTRCCTC

(p.Tyr386Cys)

ATGGGGCTGAACTCAGCCGAC′]

4831
NM_000501.3(ELN):
2006
ELN
[′TACATTGCACTGTCCCCATCTCAACRGGTG

c.800 − 2A > G

CTGGAGCAGCCGGAGTCCTCC′]

4832
NM_000117.2(EMD):
2010
EMD
[′TCTGCTACCGCTGCCCCCCTTCCCARGGCT

c.266 − 2A > G

ACAATGACGACTACTATGAAG′]

4833
NM_000191.2(HMGCL): c.698A > G
3155
HMGCL
[′GTGCCTCTGGCTGCCCTGGCTGTCCRCTGC

(p.His233Arg)

CATGACACCTATGGTCAAGCC′]

4834
NM_207352.3(CYP4V2): c.1393A >
285440
CYP4V2
[′CTACGTGCCCTTCTCTGCTGGCCCCRGGAA

G (p.Arg465Gly)

CTGTATAGGTTTGTATCCATC′]

4835
NM_013382.5(POMT2):
29954
POMT2
[′GTCAGCAGGGTGGTCTCTATTCCACRGGGC

2c.1726 − A > G

CTACGCTTCTCAGGGGTCAAT′]

4836
NM_000169.2(GLA):
−1
—
[′TTTGAATTATTTCATTCTTTTTCTCRGTTAG

c.802 − 2A > G

TGATTGGCAACTTTGGCCTC′]

4837
NM_020166.4(MCCC1):
56922
MCCC1
[′GTGTGATTTTCATGGTGTTTTAAACRGGAA

c.137 − 2A > G

GAAACATTACCAAGGTCCTCA′]

4838
NM_006920.4(SCN1A):
6323
SCN1A
[′AATATATATTAATCTTTCATTTTCCRGCTG

c.2557 − 2A > G

CGAGTTTTCAAGTTGGCAAAA′]

4839
NM_000501.3(ELN):
2006
ELN
[′CCTCACCCTCTGTGGCTGTGTTTTCRGGCG

c.890 − 2A > G

TTGGGACTCCAGCTGCAGCTG′]

4840
NM_006306.3(SMC1A):
8243
SMC1A
[′TGACATTGCTGGGCCTGGGGCTTACRGGAT

c.2974 − 2A > G

GCCCAGGCTGAGGAAGAGATC′]

4841
NM_001110792.1(MECP2):
4204
MECP2
[′TGATTTTGACTTCACGGTAACTGGGRGAGG

c.520A > G (p.Arg174Gly)

GAGCCCCTCCCGGCGAGAGCA′]

4842
NM_004646.3(NPHS1): c.1756A > G
4868
NPHS1
[′CTTGTCCTGGGACAAGGAAGGGGAGRGGT

(p.Arg586Gly)

GGGAGTGCGAGGGATCCCTCCC′]

4843
NM_003002.3(SDHD): c.275A > G
6392
SDHD
[′TATTTGAATCCTTGCTCTGCGATGGRCTAT

(p.Asp92Gly)

TCCCTGGCTGCAGCCCTCACT′]

4844
NM_004793.3(LONP1): c.2353A > G
9361
LONP1
[′CACGCTGTTTGTGGAGACATCCCTGRGACG

(p.Arg785Gly)

GCCACAGGACAAGGATGCCAA′]

4845
NC_012920.1: m.4279A > G
4565
MT-TI
[′TCAAACCTAAGAAATATGTCTGATARAAG

AGTTACTTTGATAGAGTAAATA′]

4846
NM_005633.3(SOS1): c.1430A > G
6654
SOS1
[′ATTTGCTGTAAATCAAATCATGGGCRGCCA

(p.Gln477Arg)

AGACTTCCTGGTGCTAGCAAT′]

4847
NM_000256.3(MYBPC3):
4607
MYBPC3
[′TGCCACTTCCCTGCGGCCCCCACCCRGGTA

c.1227 − 2A > G

CATCTTTGAGTCCATCGGTGC′]

4848
NM_002834.3(PTPN11): c.661A > G
5781
PTPN11
[′CGATCAGCCCCTTAACACGACTCGTDTAA

(p.Ile221Val)

ATGCTGCTGAAATAGAAAGCAG′]

4849
NM_000257.3(MYH7): c.4664A > G
−1
—
[′TCCCAGGCCTCCCTGGAGCACGAGGRGGG

(p.Glu1555Gly)

CAAGATCCTCCGGGCCCAGCTG′]

4850
NM_000257.3(MYH7): c.2792A > G
4625
MYH7
[′AACGAGAGGCTGGAGGATGAGGAGGRGA

(p.Glu931Gly)

TGAATGCTGAGCTCACTGCCAAG′]

4851
NM_000257.3(MYH7): c.2087A > G
4625
MYH7
[′CTGGTCATGCACCAGCTGCGCTGCARTGGT

(p.Asn696Ser)

GTGCTGGAGGGCATCCGCATC′]

4852
NM_000257.3(MYH7): c.1805A > G
4625
MYH7
[′CTGCAGAAGAACAAGGATCCTCTCARTGA

(p.Asn602Ser)

GACTGTCGTGGGCTTGTATCAG′]

4853
NM_000257.3(MYH7): c.1615A > G
4625
MYH7
[′CATGTCCATCCTGGAAGAGGAGTGCRTGTT

(p.Met539Val)

CCCCAAGGCCACCGACATGAC′]

4854
NM_000257.3(MYH7): c.1477A > G
4625
MYH7
[′GCTGCAGCAGTTCTTCAACCACCACRTGTT

(p.Met493Val)

TGTGCTGGAGCAGGAGGAGTA′]

4855
NM_000257.3(MYH7): c.1331A > G
4625
MYH7
[′TTCAACTGGATGGTGACGCGCATCAVTGC

(p.Asn444Ser)

CACCCTGGAGACCAAGCAGCCA′]

4856
NM_000257.3(MYH7): c.1315A > G
4625
MYH7
[′AGGGTGGCATTGATGCGCGTCACCAHCCA

(p.Met439Val)

GTTGAACATCCTCTCATACACT′]

4857
NM_000257.3(MYH7): c.1051A > G
4625
MYH7
[′TTCAGAGGAGAAAAACTCCATGTATRAGC

(p.Lys351Glu)

TGACAGGCGCCATCATGCACTT′]

4858
NM_000257.3(MYH7): c.789A > G
4625
MYH7
[′CAGGAAAGTTGGCATCTGCAGACATRGAG

(p.Ile263Met)

ACCTGTGAGTGCCATGAATCTG′]

4859
NM_000257.3(MYH7): c.617A > G
4625
MYH7
[′ATTGCAGCCATTGGGGACCGCAGCARGAA

(p.Lys206Arg)

GGACCAGAGCCCGGGCAAGGTA′]

4860
NM_000363.4(TNNI3): c.616A > G
7137
TNNI3
[′ACTGAGTGGAATGGAGGGCCGCAAGVAAA

(p.Lys206Glu)

AGTTTGAGAGCTGAGCCTTCCT′]

4861
NM_000363.4(TNNI3): c.547A > G
7137
TNNI3
[′GCAGGTGAAGAAGGAGGACACCGAGRAG

(p.Lys183Glu)

GTGAGTGTGGGCTAAGGCCAGGA′]

4862
NM_000169.2(GLA):
−1
—
[′TGACTCTTTTCCTCCCTCTCATTTCRGGTTC

c.370 − 2A > G

ACAGCAAAGGACTGAAGCTA′]

4863
NM_000051.3(ATM): c.1A > G
472
ATM
[′GATGTGTGTTCTGAAATTGTGAACCVTGAG

(p.Met1Val)

TCTAGTACTTAATGATCTGCT′]

4864
NM_000051.3(ATM):
472
ATM
[′TATTTAACCACAGTTCTTTTCCCGTRGGCT

c.3154 − 2A > G

GATCCTTATTCAAAATGGGCC′]

4865
NM_024675.3(PALB2):
79728
PALB2
[′AGTTATATACATTTTTTTCCTCCTCRGAAC

c.212 − 2A > G

CTAAAAATAAAATATGTGTTT′]

4866
NM_024675.3(PALB2):
79728
PALB2
[′TTCTGGGGCTGTTTTTGTCTCCTCTRGCGTG

c.109 − 2A > G

CCCAAAGAGCTGAAAAGATT′]

4867
NM_000546.5(TP53): c.709A > G
7157
TP53
[′CTGTACCACCATCCACTACAACTACRTGTG

(p.Met237Val)

TAACAGTTCCTGCATGGGCGG′]

4868
NM_000455.4(STK11): c.889A > G
6794
STK11
[′GATGCTTGAGTACGAACCGGCCAAGRGGT

(p.Arg297Gly)

TCTCCATCCGGCAGATCCGGCA′]

4869
NM_017777.3(MKS1): c.1382A > G
54903
MKS1
[′TCTCTGGAACTGGAGGACCTCTCCTRTGTA

(p.Tyr461Cys)

CGGATACCAGGATCCTTCAAG′]

4870
NM_001231.4(CASQ1): c.731A > G
844
CASQ1
[′ATGGAAGAGCCTGTGACCATCCCAGRCAA

(p.Asp244Gly)

GCCCAATAGCGAAGAGGAGATT′]

4871
NM_001242896.1(DEPDC5):
9681
DEPDC5
[′GTATGAGCAATCATCTGTTGTTTTCRGGAG

c.2355 − 2A > G

GGACGAAGATGGTGTGCAGAT′]

(p.Arg785_Gly839del)

4872
NM_001039550.1(DNAJB2):
3300
DNAJB2
[′TGACCAGTTGCCATGGCATCCTACTRCGAG

c.14A > G (p.Tyr5Cys)

ATCCTAGACGTGCCGCGAAGT′]

4873
NM_007294.3(BRCA1): c.5057A >
672
BRCA1
[′AATCTAATTACTGAAGAGACTACTCRTGTT

G (p.His1686Arg)

GTTATGAAAACAGGTATACCA′]

4874
NM_006888.4(CALM1): c.389A > G
801
CALM1
[′GTAGATGAAATGATCAGAGAAGCAGRTAT

(p.Asp130Gly)

TGATGGAGACGGACAAGTCAAC′]

4875
NM_001082538.2(TCTN1):
79600
TCTN1
[′TTGTATTATTATTTTTTTAATTTTCRGGGGC

c.342 − 2A > G

GACAGCCAGTTTTGTAGTCA′]

4876
NM_003000.2(SDHB):
6390
SDHB
[′TCCTGCCTCTCTTTTCTCCCCATACRGGAC

c.541 − 2A > G

GGGCTCTACGAGTGCATTCTC′]

4877
NM_000143.3(FH): c.700A > G
2271
FH
[′AGTGGAACAGCATCCTGAGTATGAGYACG

(p.Thr234Ala)

TCCAATCTTGATGATCTGTGCA′]

4878
NM_000038.5(APC):
324
APC
[′ATAAAAACTTGTTTCTATTTTATTTRGAGC

c.221 − 2A > G

TTAACTTAGATAGCAGTAATT′]

4879
NM_000314.6(PTEN): c.527A > G
5728
PTEN
[′ATTCCCAGTCAGAGGCGCTATGTGTRTTAT

(p.Tyr176Cys)

TATAGCTACCTGTTAAAGAAT′]

4880
NM_030813.5(CLPB): c.1850A > G
81570
CLPB
[′CTGGTCGACGGCTACAATGTGCACTRTGGC

(p.Tyr617Cys)

GCCCGCTCCATCAAACATGAG′]

4881
NM_030813.5(CLPB): c.1222A > G
81570
CLPB
[′TCCTGGAACTCGGACATGTCCAGCCHGAT

(p.Arg408Gly)

GAAGCCCTGTGTGGAAACAAGC′]

4882
NM_016069.9(PAM16): c.226A > G
−1
—
[′CTCACCCGTCCCCTCTCCTCTGCAGRACTA

(p.Asn76Asp)

TGAACACTTATTTAAGGTGAA′]

4883
NM_058163.1(TSR2): c.191A > G
90121
TSR2
[′TACTTAGCTGACTTGGAGCTAGATGRGGTG

(p.Glu64Gly)

GAAGACTTCCTTGGAGAGCTG′]

4884
NM_001031.4(RPS28): c.1A > G
6234
RPS28
[′ATAGGCTGCACACGGCTGGTGTCCAYGAT

(p.Met1Val)

GGCGGCGCGGCGGCGGTCTGGC′]

4885
NM_005957.4(MTHFR): c.1114A >
4524
MTHFR
[′TCCCATCTTCTGGGCCTCCAGACCARAGAG

G (p.Lys372Glu)

TTACATCTACCGTACCCAGGA′]

4886
NM_014946.3(SPAST): c.1165A > G
6683
SPAST
[′CTTTGGTCCACCTGGGAATGGGAAGRCAA

(p.Thr389Ala)

TGCTGGTAAGGGTTCTCTTCAA′]

4887
NM_000228.2(LAMB3):
3914
LAMB3
[′TAAATCCATAAGGTTAAGTTGGACCYACA

2c.565 − A > G

GAGGGAAGGGAAAGAGAAGCGC′]

4888
NM_000492.3(CFTR):
1080
CFTR
[′TCATTTACGTCTTTTGTGCATCTATDGGAG

c.3368 − 2A > G

AAGGAGAAGGAAGAGTTGGTA′]

4889
NM_006785.3(MALT1):
10892
MALT1
[′AACACCCCCTTTCTTTTTTTTTCAARGCGA

c.1019 − 2A > G

AGGACAAGGTTGCCCTTTTGA′]

4890
NM_004771.3(MMP20): c.611A > G
9313
MMP20
[′GGAGAAGGCCTGGGAGGAGATACACRTTT

(p.His204Arg)

CGACAATGCTGAGAAGTGGACT′]

4891
NM_000918.3(P4HB): c.1178A > G
5034
P4HB
[′CACCCTAGAACTGCTTTCTTTTCAGRTGCC

(p.Tyr393Cys)

CCATGGTGTGGTCACTGCAAA′]

4892
NM_177405.2(CECR1): c.355A > G
51816
CECR1
[′TGCTCGCATCCCGCAGGCTCACCTGYTTCT

(p.Thr119Ala)

CCGGCGTGGAAGAAGTAAGGC′]

4893
NM_004990.3(MARS): c.1031A > G
4141
MARS
[′TACCACATCATCCATGCTGACATCTRCCGC

(p.Tyr344Cys)

TGGTTTAACATTTCGTTTGAT′]

4894
NM_025132.3(WDR19):
57728
WDR19
[′TCTGTATAAAAATAATCTCTTTTTCRGGAA

2c.407 − A > G

AACATACTAAGAGAATCACTT′]

4895
NM_000314.6(PTEN): c.139A > G
5728
PTEN
[′TGCAGAAAGACTTGAAGGCGTATACRGGA

(p.Arg47Gly)

ACAATATTGATGATGTAGTAAG′]

4896
NM_000314.6(PTEN): c.182A > G
5728
PTEN
[′GTTTTAAGGTTTTTGGATTCAAAGCDTAAA

(p.His61Arg)

AACCATTACAAGATATACAAT′]

4897
NM_000314.6(PTEN):
5728
PTEN
[′TATTCTGAGGTTATCTTTTTACCACRGTTG

c.254 − 2A > G

CACAATATCCTTTTGAAGACC′]

4898
NM_000314.6(PTEN): c.320A > G
5728
PTEN
[′GAACTTATCAAACCCTTTTGTGAAGRTCTT

(p.Asp107Gly)

GACCAATGGCTAAGTGAAGAT′]

4899
NM_000314.6(PTEN): c.512A > G
5728
PTEN
[′CACCAGGGAGTAACTATTCCCAGTCRGAG

(p.Gln171Arg)

GCGCTATGTGTATTATTATAGC′]

4900
NM_000314.6(PTEN):
5728
PTEN
[′TTTTCTTTTCTTTTTTTTTTTTTTTDGGACAA

c.802 − 2A > G

AATGTTTCACTTTTGGGTA′]

4901
NM_001103.3(ACTN2): c.1883A >
88
ACTN2
[′ATCCGCGATCAATCCCTGCAGGAGGRGCT

G (p.Glu628Gly)

GGCTCGCCAGCATGCTAACGAG′]

4902
NM_003159.2(CDKL5):
6792
CDKL5
[′GCTTTTAATTGTGTTTGTTTTTTTCRGGGAG

c.−162 − 2A > G

TCATTTAATACTTCATGATT′]

4903
NM_003159.2(CDKL5): c.91A > G
6792
CDKL5
[′AGCCTATGGAGTTGTACTTAAATGCRGAC

(p.Arg31Gly)

ACAAGGCAAGTACATTATTTTT′]

4904
NM_003159.2(CDKL5): c.458A > G
6792
CDKL5
[′CACAATGATGTCCTAAAACTGTGTGRCTTT

(p.Asp153Gly)

GGTAAGTTAAAAAGAAATTAA′]

4905
NM_003159.2(CDKL5):
6792
CDKL5
[′ATATGATAAAAATGTCTTCTCATTTRGGAA

c.2277 − 2A > G

AAGTCCTGAAAATATTAGTCA′]

4906
NM_021098.2(CACNA1H):
8912
CACNA1H
[′CATCGTCAGCTTCTTCGTGCTCAACRTGTT

c.4645A > G (p.Met1549Val)

CGTGGGCGTCGTGGTCGAGAA′]

4907
NM_003816.2(ADAM9):
8754
ADAM9
[′TGTTTAATTTGAATTCTATTTCACTRGTTCC

c.1396 − 2A > G

TTCCAGGAGGTACTTTATGC′]

4908
NM_212472.2(PRKAR1A):
5573
PRKAR1A
[′AATACTTTGAGAGGTTGGAGAAGGTRAAA

c.177 +3 A > G

ATAAATGTGGGGAGATGATGAG′]

4909
NM_001204830.1(LIPT1): c.535A >
−1
—
[′CCGGACTACTGCCTATCACCATTGCRCTTT

G (p.Thr179Ala)

ATTATGTAGTACTGATGGGAC′]

4910
NM_001165963.1(SCN1A):
−1
—
[′AACCCTGGAAGCTCAGTTAAGGGAGRCTG

c.5264A > G (p.Asp1755Gly)

TGGGAACCCATCTGTTGGAATT′]

4911
NM_001165963.1(SCN1A):
−1
—
[′TAATTGTTATTATTTTTGTGTGTGCRGGTTT

c.3880 − 2A > G

CATTGGTCAGTTTAACAGCA′]

4912
NM_001165963.1(SCNIA):
6323
SCN1A
[′TTTATTGTGACGCTTAGCCTGGTAGRACTT

c.2537A > G (p.Glu846Gly)

GGACTCGCCAATGTGGAAGGA′]

4913
NM_001165963.1(SCNIA):
6323
SCN1A
[′GTCATTGGATAGTGCTCCATGGCCAHGAA

c.2353A > G (p.Met785Val)

AAGAGTATTTAAGACAATACAG′]

4914
NM_001165963.1(SCN1A):
6323
SCN1A
[′AGAGGTACTCCTCCCCACACCAGGTRTGG

c.1662 + 3A > G

CACTGCTGAGTTTACTGATGCA′]

4915
NM_001165963.1(SCN1A):
6323
SCN1A
[′TGTGTGAAAGCTGGTAGAAATCCCADTTA

c.1076A > G (p.Asn359Ser)

TGGCTACACAAGCTTTGATACC′]

4916
NM_001165963.1(SCN1A):
6323
SCN1A
[′TTGCAGCCAATGTCCAGAGGGATATRTGT

c.1048A > G (p.Met350Val)

GTGTGAAAGCTGGTAGAAATCC′]

4917
NM_001165963.1(SCN1A):
6323
SCN1A
[′ACTTGCAGCCAATGTCCAGAGGGATRTAT

c.1046A > G (p.Tyr349Cys)

GTGTGTGAAAGCTGGTAGAAAT′]

4918
NM_001165963.1(SCN1A):
6323
SCN1A
[′CACTATTTTGACAAACTGTGTGTTTRTGAC

c.433A > G (p.Met145Val)

AATGAGTAACCCTCCTGATTG′]

4919
NM_001165963.1(SCN1A):
6323
SCN1A
[′TAGCTATTAAGATTTTGGTACATTCRTATC

c.383 + 1A > G

CTTTTTCAAGTGATTAATATT′]

4920
NM_001605.2(AARS): c.2251A > G
16
AARS
[′TCGGCACCTGTGACAGCCACAATCCYCCG

(p.Arg751Gly)

GATACCCTTGGCAATGGCTTCT′]

4921
NM_000124.3(ERCC6):
2074
ERCC6
[′TATTCTCCATGCTCGCTCCCGGGCCYGCAA

c.2830 − 2A > G

CAGAGAGAGAGAGACCTCTCA′]

4922
NM_000124.3(ERCC6):
2074
ERCC6
[′ACTGGGAATGTGTATTTGCTTTGCAVACTC

c.2599 − 26A > G

CTATCCCCCACCTCCAAACAG′]

4923
NM_001110556.1(FLNA):
2316
FLNA
[′ACTGAGGGGACTGGTGGCTGTTGTCRGGC

c.1829 − 2A > G

TTCTCGGTGGAAGGGCCATCGC′]

4924
NM_006129.4(BMP1): c.808A > G
649
BMP1
[′GGAGACCTATGACTTCGACAGCATCRTGC

(p.Met270Val)

ATTACGCTCGGAACACATTCTC′]

4925
NM_001987.4(ETV6): c.1252A > G
2120
ETV6
[′GGAGCCAGGACAAAGGCTTTTGTTCRGGT

(p.Arg418Gly)

AGCACTTCCTTTTTCTCCTTTC′]

4926
NM_014423.3(AFF4): c.760A > G
27125
AFF4
[′GTCCAATTCAATGTTACAGAAACCCRCTGC

(p.Thr254Ala)

CTATGTGCGGCCCATGGACGG′]

4927
NM_002055.4(GFAP): c.1085A > G
2670
GFAP
[′AATGTCAAGCTGGCCCTGGACATCGRGAT

(p.Glu362Gly)

CGCCACCTACAGGAAGCTGCTA′]

4928
NM_002055.4(GFAP): c.256A > G
2670
GFAP
[′TGACCGCTTTGCCAGCTACATCGAGRAGGT

(p.Lys86Glu)

TCGCTTCCTGGAACAGCAAAA′]

4929
NM_006017.2(PROM1):
8842
PROM1
[′ATTTGCTGTTCTTCACAGCTTTAGGRTATG

c.2077 − 521A > G

TATCCAATGTTTTCTTCAGGT′]

4930
NM_002755.3(MAP2K1): c.305A >
5604
MAP2K1
[′ACCTTTCTCCAGCTAATTCATCTGGRGATC

G (p.Glu102Gly)

AAACCCGCAATCCGGAACCAG′]

4931
NM_001288953.1(TTC7A):
57217
TTC7A
[′CGTCCCCACAGCCTGATGTTCACCARGGTG

Ac.1715 > G (p.Lys572Arg)

AAGCTGGAGCAGGTGCTGAAA′]

4932
NM_016218.2(POLK): c.181A > G
51426
POLK
[′TGAGCTCAAGAAAGAAAAGCAAGTCRACC

(p.Asn61Asp)

AACGAATTGAAAATATGATGCA′]

4933
NM_016218.2(POLK): c.1385A > G
51426
POLK
[′AGAACTGTTACCATTAAGTTGAAGARTGT

(p.Asn462Ser)

GAATTTTGAAGTAAAAACTCGT′]

4934
NM_016218.2(POLK): c.1477A > G
51426
POLK
[′ATTTGCCATTGCTAAGGAATTGCTARAAAC

(p.Lys493Glu)

AGAAATTGATGCTGATTTTCC′]

4935
NM_001040431.2(COA3): c.215A >
28958
COA3
[′GGAAATCGAGTAGAAGGTGTAACCAYCTG

G (p.Tyr72Cys)

GGGAGGTAGGTTCAGGAAACCA′]

4936
NM_000891.2(KCNJ2): c.901A > G
3759
KCNJ2
[′TGAAATCGTGGTCATACTGGAAGGCRTGG

(p.Met301Val)

TGGAAGCCACTGCCATGACGAC′]

4937
NM_144499.2(GNAT1): c.386A > G
2779
GNAT1
[′GACATCATCCAGCGGCTGTGGAAGGRCTC

(p.Asp129Gly)

CGGTATCCAGGCCTGTTTTGAG′]

4938
NM_018965.3(TREM2): c.113A > G
54209
TREM2
[′CAGTCCCTGCAGGTGTCTTGCCCCTRTGAC

(p.Tyr38Cys)

TCCATGAAGCACTGGGGGAGG′]

4939
NM_194277.2(FRMD7): c.556A > G
90167
FRMD7
[′ACTGGACATAGCAAGGAAGCTGGATRTGT

(p.Met186Val)

ATGGCATCAGGCCTCACCCCGC′]

4940
NM_001003811.1(TEX11):
56159
TEX11
[′TCACTCTCAACAGTAATCTTCTCCAYGGTC

c.511A > G (p.Met171Val)

AAGTCAGCCTCAGGGGAGCTC′]

4941
NM_000921.4(PDE3A): c.1333A > G
5139
PDE3A
[′AGTTTCTTCCACTTGGACCACCACCRCCTC

(p.Thr445Ala)

GGCCACAGGTCTACCCACCTT′]

4942
NM_000033.3(ABCD1): c.887A > G
215
ABCD1
[′GCCAACTCGGAGGAGATCGCCTTCTRTGG

(p.Tyr296Cys)

GGGCCATGAGGTGGGGCAGGTT′]

4943
NM_000169.2(GLA): c.137A > G
−1
—
[′AGGACGCCTACCATGGGCTGGCTGCDCTG

(p.His46Arg)

GGAGCGCTTCATGTGCAACCTT′]

4944
NM_000033.3(ABCD1):
215
ABCD1
[′CCCTGACCCTGTCCCTCTCCTGGCCRGGAA

c.1992 − 2A > G

ATACCACACACACTTGCTACA′]

4945
NM_000182.4(HADHA):
3030
HADHA
[′TTGCTCAATTCCAGTCTTTACCACCYAAAA

c.919 − 2A > G

AACATATAAAGCACTTGCTCA′]

4946
NM_000159.3(GCDH): c.1213A > G
2639
GCDH
[′CGAGTATCACGTGATCCGGCACGCCRTGA

(p.Met405Val)

ACCTGGAGGCCGTGAACACCTA′]

4947
NM_004006.2(DMD):
1756
DMD
[′ACAATTGTTAACTTCCTTCTTTGTCRGGGG

c.1150 − 2A > G

TACATGATGGATTTGACAGCC′]

4948
NM_019109.4(ALG1):
56052
ALG
[′CTCAGGCTCCCTTGGTTCTCTCTGCRGTTT

c.1188 − 2A > G

ACATGAGCTGGTGAAACATGA′]

4949
NM_004463.2(FGD1):
2245
FGD1
[′TCTTTCTTTTTTATTCCCCACCCCARGGACT

c.2016 − 2A > G

GAGGAGGAGAAGAAAGACTG′]

4950
NM_198525.2(KIF7): c.2981A > G
374654
KIF7
[′CTGCTGCTGGCTCTGGGCGCTGCCCYGCCG

(p.Gln994Arg)

CAGCTGCCCGCTCTTCTCGGA′]

4951
NM_020366.3(RPGRIP1):
57096
RPGRIP1
[′ATGCTGTTTTTTTCCCTTTCCCAACRGTTGT

c.3749 − 2A > G

TAGCCCTGAAGATCTGGCTA′]

4952
NM_003494.3(DYSF): c.3041A > G
8291
DYSF
[′GTTCCCCCTCCCCCAGGCTGGGAGTRTAGC

(p.Tyr1014Cys)

ATCACCATCCCCCCGGAGCGG′]

4953
NM_003494.3(DYSF):
8291
DYSF
[′CTGCCATAACCAGCTTCGTGTCTCCRGGGC

c.3349 − 2A > G

GGCGTGATGGATGACAAGAGT′]

4954
NM_004006.2(DMD):
1756
DMD
[′ATTACATTTCATTATAATTCTTTTCRGGTA

c.4675 − 2A > G

ACAGAAAGAAAGCAACAGTTG′]

4955
NM_000169.2(GLA): c.620A > G
−1
—
[′GTGTACTCCTGTGAGTGGCCTCTTTRTATG

(p.Tyr207Cys)

TGGCCCTTTCAAAAGGTGAGA′]

4956
NM_022124.5(CDH23):
−1
—
[′CTCTGCTCTCTCCCTTGGCTACTCCRGGTTC

c.146 − 2A > G

TTCTGTGACCCAGTTGCTGG′]

4957
NM_000169.2(GLA):
−1
—
[′GGGGTTGGAATGACCCAGATATGGTRAAA

c.801 + 3A > G

ACTTGAGCCCTCCTTGTTCAAG′]

4958
NM_000019.3(ACAT1): c.473A > G
38
ACAT1
[′GCAGGTGGGATGGAGAGCATGTCCARTGT

(p.Asn158Ser)

TCCATATGTAATGAACAGAGGA′]

4959
NM_000553.4(WRN): c.561A > G
7486
WRN
[′GTCTGGTTAAACACCTCTTAGGTAARCAGC

(p.Lys187=)

TCCTGAAAGACAAGTCTATCC′]

4960
NM_000050.4(ASS1):
445
ASS1
[′GGCTCTGACCCCTTGTCCTATGTCCDGGTC

c.421 − 2A > G

ATTGCTCCCTGGAGGATGCCT′]

4961
NM_020166.4(MCCC1):
56922
MCCC1
[′TTCTGATCTAACAATCCTCATTCCCYAAGA

c.640 − 2A > G

GAGAAAAGATGATTATGACTA′]

4962
NM_004006.2(DMD):
1756
DMD
[′TCTTTTTTACTTTTTTGATGCCAATRGGAAT

c.10554 − 2A > G

CTGCAAGCAGAATATGACCG′]

4963
NM_017653.3(DYM):
54808
DYM
[′ACAAGTTTGCTGGTGTATGGAAGACYATA

c.621 − 2A > G

CAAAAAGGAAAAAAAAATCAAA′]

4964
NM_001098398.1(COPA): c.728A >
−1
—
[′TCAGAATCAAAGGCATGGGAGGTTGRTAC

G (p.Asp243Gly)

CTGCCGGGGCCATTACAACAAT′]

4965
NM_005045.3(RELN): c.2288A > G
5649
RELN
[′CGTCAGCTAATTACATCTTTCCTTGRCAGC

(p.Asp763Gly)

TCACAATCCAGGTGAGTGAAG′]

4966
NM_207111.3(RNF216): c.1616A >
54476
RNF216
[′TGCCATCTCTTTGATTTTCTGCTCAHAGAA

G (p.Tyr539Cys)

CTCCTGCTCTTGTTGCACAGC′]

4967
NM_001035.2(RYR2): c.568A > G
6262
RYR2
[′CATCTTAGTTAGCGTGTCCTCTGAARGGTA

(p.Arg190Gly)

CTTGGTAAGTGTGGAAAGTAG′]

4968
NM_001035.2(RYR2): c.11965A > G
6262
RYR2
[′AAATGCAACTGCTTTACCACCAGGTVATGT

(p.Asn3989Asp)

TGTTAATGGAACGATTGGCAA′]

4969
NM_001035.2(RYR2): c.12290A > G
6262
RYR2
[′GAACCTGCGAAGGACATCGGCTTCARCGT

(p.Asn4097Ser)

CGCCGTCCTTCTGACAAACCTC′]

4970
NM_001035.2(RYR2): c.12533A > G
6262
RYR2
[′AGACAGTTCATATTTGACGTGGTCARCGA

(p.Asn4178Ser)

AGGCGGAGAGAAAGAGAAGATG′]

4971
NM_000090.3(COL3A1):
1281
COL3A1
[′ACAGTGACATGGCTTCTCTTTTTCCRGGGT

c.2338 − 2A > G

GAAGGTGGTGCCCCCGGACTT′]

4972
NM_198056.2(SCN5A): c.4462A > G
6331
SCN5A
[′CTTAGGGGGCCAGGACATCTTCATGRCAG

(p.Thr1488Ala)

AGGAGCAGAAGAAGTACTACAA′]

4973
NM_198056.2(SCN5A): c.4453A > G
6331
SCN5A
[′CTCTTTGCACTTAGGGGGCCAGGACRTCTT

(p.Ile1485Val)

CATGACAGAGGAGCAGAAGAA′]

4974
NM_198056.2(SCN5A):
6331
SCN5A
[′GGTGAGCCTGACCCATTATCTCGACRGGTC

c.2788 − 2A > G

CTGAATCTCTTCCTGGCCTTG′]

4975
NM_198056.2(SCN5A): c.1247A > G
6331
SCN5A
[′GATGGTGGCTTGGTTTTGCTCCTCAYAGGC

(p.Tyr416Cys)

CATTGCGACCACGGCCAGGAT′]

4976
NM_004415.2(DSP):
1832
DSP
[′TTCACTGATCACTCTCATCCTTCACRGTTTT

c.1141 − 2A > G

TTGAAGAGGCGCAGTCTACT′]

4977
NM_000238.3(KCNH2): c.2582A >
3757
KCNH2
[′TGGTCCAGCCTGGAGATCACCTTCANCCTG

G (p.Asn861Ser)

CGAGATGTGAGTTGGCTGCCC′]

4978
NM_000238.3(KCNH2): c.1913A >
3757
KCNH2
[′GTCTCTCCCAACACCAACTCAGAGARGAT

G (p.Lys638Arg)

CTTCTCCATCTGCGTCATGCTC′]

4979
NM_000238.3(KCNH2): c.1904A >
3757
KCNH2
[′TTCGGCAACGTCTCTCCCAACACCADCTCA

G (p.Asn635Ser)

GAGAAGATCTTCTCCATCTGC′]

4980
NM_000238.3(KCNH2): c.1900A >
3757
KCNH2
[′GGGCTTCGGCAACGTCTCTCCCAACRCCAA

G (p.Thr634Ala)

CTCAGAGAAGATCTTCTCCAT′]

4981
NM_000238.3(KCNH2):
3757
KCNH2
[′CCACACCTCCGCCTTCCCCGGGTGCRGGTC

c.1129 − 2A > G

CTGTCCCTGGGCGCCGACGTG′]

4982
NM_000238.3(KCNH2): c.296A > G
3757
KCNH2
[′GAGCGCAAAGTGGAAATCGCCTTCTVCCG

(p.Tyr99Cys)

GAAAGATGGTAGGAGCGGGCCG′]

4983
NM_000238.3(KCNH2): c.133A > G
3757
KCNH2
[′GGAGAACTGCGCCGTCATCTACTGCDACG

(p.Asn45Asp)

ACGGCTTCTGCGAGCTGTGCGG′]

4984
NM_001613.2(ACTA2): c.1A > G
59
ACTA2
[′AGAATCCTGTGAAGCAGCTCCAGCTRTGT

(p.Met1Val)

GTGAAGAAGAGGACAGCACTGC′]

4985
NM_000218.2(KCNQ1): c.605A > G
3784
KCNQ1
[′GCTCCCCCTCTCCTGCACTCCACAGRCCTC

(p.Asp202Gly)

ATCGTGGTCGTGGCCTCCATG′]

4986
NM_000218.2(KCNQ1):
3784
KCNQ1
[′GGGAGCCTCCTGTCCATTCCTTCCCVGGGG

c.1033 − 2A > G

ATTCTTGGCTCGGGGTTTGCC′]

4987
NM_000218.2(KCNQ1):
3784
KCNQ1
[′CAATCTCCTCTCCTCTCTCCACTGCRGGCT

c.1515 − 2A > G

GCGGGAACACCATCGGGCCAC′]

4988
NM_000218.2(KCNQ1): c.1787A >
3784
KCNQ1
[′ATCGGCGCCCGCCTGAACCGAGTAGRAGA

G (p.Glu596Gly)

CAAGGTAGGCTCACGCGCCGGC′]

4989
NM_000138.4(FBN1): c.7916A > G
2200
FBN1
[′TGCATGTGTCCCGCCGGCTTCCAGTRTGAA

(p.Tyr2639Cys)

CAGTTCAGTGGAGGATGCCAA′]

4990
NM_000138.4(FBN1)
2200
FBN1
[′TTTTGCTTTTTTCTCCCTCCCCCCARGATAT

c.4337 − 2A > G

TGATGAGTGCTCCCTTCCGA′]

4991
NM_000138.4(FBN1): c.3344A > G
2200
FBN1
[′GGTCATTTCCATTTTGCAGATATTGRTGAG

(p.Asp1115Gly)

TGTCAGAGAGATCCTCTCCTA′]

4992
NM_001943.3(DSG2): c.880A > G
1829
DSG2
[′AGTCAACGTAGAAGTTACGCGCATARAAG

(p.Lys294Glu)

TGTTCGATGCAGATGAAATAGG′]

4993
NM_001927.3(DES): c.1324A > G
1674
DES
[′TGAGCAAAGGGGTTCTGAGGTCCATRCCA

(p.Thr442Ala)

AGAAGACGGTGATGATCAAGAC′]

4994
NM_004572.3(PKP2):
5318
PKP2
[′AGAAATATGCATCTGCTTCTTCCCCRGGTT

c.1171 − 2A > G

AACCAGCTTCGTGGCATCCTC′]

4995
NM_001256850.1(TTN):
−1
—
[′GATATGAATATTTCACTCTTTTCTCRGGTC

c.45629 − 2A > G

CTCCCTCACCACCCCTTGACC′]

4996
NM_013254.3(TBK1): c.1201A > G
29110
TBK1
[′ACTTCATATTTCAGTTTCCCTCCCTRAAGT

(p.Lys401Glu)

ACATCCACGTTATGATTTAGA′]

4997
NM_030973.3(MED25): c.116A > G
81857
MED25
[′TACTTCGAGGGGCTCCGCAAGCACTRCCTG

(p.Tyr39Cys)

CTCCCGGCCATCGAGTGAGTG′]

4998
NM_145207.2(SPATA5): c.1883A >
166378
SPATA5
[′TCTATTTTTCAGGTATCCTGGTCAGRTATA

G (p.Asp628Gly)

GGAGGACTGGAAAGTATCAAA′]

4999
NM_000016.5(ACADM): c.329A >
34
ACADM
[′ACTTTTGATGCTTGTTTAATTAGTGRAGAA

G (p.Glu110Gly)

TTGGCTTATGGATGTACAGGG′]

5000
NM_000016.5(ACADM): c.797A >
34
ACADM
[′CCTAAAGAAAATGTTTTAATTGGTGRCGG

G (p.Asp266Gly)

AGCTGGTTTCAAAGTTGCAATG′]

5001
NM_000532.4(PCCB):
5096
PCCB
[′GACTGTTCTGGAAATCTTTTATTTCRGGAC

c.655 − 2A > G

ACCTCCTACCTGTTCATCACT′]

5002
NM_004453.3(ETFDH): c.929A > G
2110
ETFDH
[′CATACCTATGGAGGATCTTTCCTCTRTCAT

(p.Tyr310Cys)

TTGAATGAAGGTGAACCCCTA′]

5003
NM_000255.3(MUT): c.1885A > G
4594
MUT
[′AAAAATGGGACAAGATGGCCATGACRGAG

(p.Arg629Gly)

GAGCAAAAGTTATTGCTACAGG′]

5004
NM_000255.3(MUT): c.329A > G
4594
MUT
[′TTTAGGCCCTGGACCATCCGCCAGTRTGCT

(p.Tyr110Cys)

GGTTTTAGTACTGTGGAAGAA′]

5005
NM_000017.3(ACADS): c.1108A >
35
ACADS
[′TCAGGCCATCCAGATCCTGGGCGGCRTGG

G (p.Met370Val)

GCTACGTGACAGAGATGCCGGC′]

5006
NM_174917.4(ACSF3): c.1A > G
197322
ACSF3
[′TCCAGCTCGGCCGCCTGTCAGTGCARTGCT

(p.Met1Val)

GCCCCATGTGGTGCTCACCTT′]

5007
NM_000531.5(OTC): c.919A > G
5009
OTC
[′GACATTTTTACACTGCTTGCCCAGARAGCC

(p.Lys307Glu)

AGAAGAAGTGGATGATGAAGT′]

5008
NM_000030.2(AGXT): c.248A > G
189
AGXT
[′ACACTGGTCATCTCTGGCTCGGGACRCTGT

(p.His83Arg)

GCCCTGGAGGCCGCCCTGGTC′]

5009
NM_000030.2(AGXT):
189
AGXT
[′CACCCACAGCCGTCCCTGCTTCCTCRGGGC

c.424 − 2A > G

CTGGCCCAGCACAAGCCAGTG′]

(p.Gly_142Gln145del)

5010
NM_000030.2(AGXT):
189
AGXT
[′CGTCCCGAGCAAACCACCCATCTACRGGC

c.596 − 2A > G

ATCGACATCCTGTACTCGGGCT′]

5011
NM_000030.2(AGXT):
189
AGXT
[′TGGACCAAGCCCCCTCGTGTCTTCCRGGTA

c.777 − 2A > G

CCATCACACAATCCCCGTCAT′]

5012
NM_012203.1(GRHPR):
9380
GRHPR
[′CTCCTGAGGGCCTCCCTTTCCCCGCRGCTG

c.84 − 2A > G

TGAGGTGGAGCAGTGGGACTC′]

5013
NM_012203.1(GRHPR): c.934A > G
9380
GRHPR
[′CACCATGTCCTTGTTGGCAGCTAACRACTT

(p.Asn312Asp)

GCTGGCTGGCCTGAGAGGGGA′]

5014
NM_203290.2(POLRIC): c.221A >
9533
POLRIC
[′GTGGGAATTGACGCAGCCATTGCCARTGC

G (p.Asn74Ser)

TTTTCGACGAATTCTGCTAGCT′]

5015
NM_006516.2(SLC2A1): c.848A > G
6513
SLC2A1
[′GCTGTGGTGCTGCAGCTGTCCCAGCRGCTG

(p.Gln283Arg)

TCTGGCATCAACGCTGTGAGT′]

5016
NM_006516.2(SLC2A1):
6513
SLC2A1
[′ATAACAGTGTGGTTTGTTTCTCCGCRGAAG

c.19 − 2A > G

CTGACGGGTCGCCTCATGCTG′]

5017
NM_021007.2(SCN2A):
6326
SCN2A
[′ACTTTGTCTTCCTTGACGATATTCTRCTTTA

c.387 − 2A > G

TTCAATATGCTCATTATGTG′]

5018
NM_021007.2(SCN2A): c.851A > G
6326
SCN2A
[′AATAAATGTTTGCAATGGCCTCCAGRTAAT

(p.Asp284Gly)

TCTTCCTTTGAAATAAATATC′]

5019
NM_021007.2(SCN2A): c.4036A > G
6326
SCN2A
[′CATGAATGTACTTCTGGTTTGTCTGRTCTTT

(p.Ile1346Val)

TGGCTAATATTCAGTATCAT′]

5020
NM_001165963.1(SCN1A):
−1
—
[′TAATTTCAACCAGCAGAAAAAGAAGDTAA

c.4476 + 1A > G

GTATTTCTAATATTTTCTCTCC′]

5021
NM_001165963.1(SCN1A):
6323
SCN1A
[′ATCCTGGCTGTGGTGGCCATGGCCTRCGAG

c.1277A > G (p.Tyr426Cys)

GAACAGAATCAGGCCACCTTG′]

5022
NM_000391.3(TPP1): c.833A > G
1200
TPP1
[′GGGATTGAGGCCAGTCTAGATGTGCRGTA

(p.Gln278Arg)

CCTGATGAGTGCTGGTGCCAAC′]

5023
NM_017882.2(CLN6): c.767A > G
54982
CLN6
[′GGAGAAGAGGAAGAGGCCGTTGCTGYCCA

(p.Asp256Gly)

GGAAGAGGCGCTTGCGCTTCTG′]

5024
NM_002693.2(POLG): c.3470A > G
5428
POLG
[′GGGCCCCGCATACCTGGTCAAGAGGYTGG

(p.Asn1157Ser)

TGATCTGCAAGGCCAGGGCAGC′]

5025
NM_002693.2(POLG): c.2840A > G
5428
POLG
[′GTGGGCATCAGCCGTGAGCATGCCARAAT

(p.Lys947Arg)

CTTCAACTACGGCCGCATCTAT′]

5026
NM_002693.2(POLG): c.2636A > G
5428
POLG
[′CACAAGGGTGTAGCCAGGTGGGGCCYGCA

(p.Gln879Arg)

CCATGGCTTTCAACTCACTGCC′]

5027
NM_000833.4(GRIN2A): c.2449A >
2903
GRIN2A
[′GAGCAGCCAGCTGGACATTGACAACRTGG

G (p.Met817Val)

CGGGCGTATTCTACATGCTGGC′]

5028
NM_000833.4(GRIN2A): c.1930A >
2903
GRIN2A
[′CTTCTTCGCTGTCATATTCCTGGCTRGCTA

G (p.Ser644Gly)

CACAGCCAATCTGGCTGCCTT′]

5029
NM_000156.5(GAMT): c.1A > G
2593
GAMT
[′GTCGGGTCGCCGTCCAGCCTGCAGCRTGA

(p.Met1Val)

GCGCCCCCAGCGCGACCCCCAT′]

5030
NM_172107.2(KCNQ2): c.848A > G
3785
KCNQ2
[′CTGACCACCATTGGCTACGGGGACARGTA

(p.Lys283Arg)

CCCCCAGACCTGGAACGGCAGG′]

5031
NM_172107.2(KCNQ2): c.611A > G
3785
KCNQ2
[′GCGCTCCGGAGCCTGCGCTTCCTGCRGATT

(p.Gln204Arg)

CTGCGGATGATCCGCATGGAC′]

5032
NM_172107.2(KCNQ2):
3785
KCNQ2
[′CTGAGAGCGCGCGTTCCCTGCCCCCRGGTT

c.297 − 2A > G

CCTCCTGGTTTTCTCCTGCCT′]

5033
NM_001105243.1(PCDH19):
57526
PCDH19
[′GTCACCGTCAGCGTGCTGGACACCARTGA

c.1019A > G (p.Asn340Ser)

CAATCCGCCGGTCATCAACCTG′]

5034
NM_001105243.1(PCDH19):
57526
PCDH19
[′CTTAGTATCAAGGTGACCGACTCCADTGA

c.695A > G (p.Asn232Ser)

CAACAACCCGGTGTTTAGCGAG′]

5035
NM_052859.3(RFT1): c.454A > G
91869
RFT1
[′TTCACAGCAGAAGGTGCACTGACCTBGAG

(p.Lys152Glu)

CTTCACAAACATATGTGCTTGT′]

5036
NM_052859.3(RFT1): c.1222A > G
91869
RFT1
[′TCTCCTCCCCAGGTACAATTTTGTGRTGCT

(p.Met408Val)

GGCCCTGTCCTCCTCATTCCT′]

5037
NM_020533.2(MCOLN1):
57192
MCOLN1
[′TCTGAGTGCCTGTTCTCGCTCATCARTGGG

c.1406A > G (p.Asn469Ser)

GACGACATGTTTGTGACGTTC′]

5038
NM_004456.4(EZH2): c.458A > G
2146
EZH2
[′TTCATTGAAGAACTAATAAAAAATTRTGAT

(p.Tyr153Cys)

GGGAAAGTACACGGGGATAGA′]

5039
NM_005045.3(RELN): c.2168A > G
5649
RELN
[′ACCACGGATAGAGTAAAAGTTATGGYAAG

(p.Tyr723Cys)

AGGAGAGCCTGGAACTGCCAAA′]

5040
NM_006772.2(SYNGAP1):
8831
SYNGAP1
[′CCCACCCCATCCCCATTTCCCCCCCRGCAA

c.388 − 2A > G

GGCTTCCTGAGCCGACGGCTA′]

5041
NM_001080508.2(TBX18):
9096
TBX18
[′GATAGGCACTGAGATGATCATCACCRAGG

c.487A > G (p.Lys163Glu)

CCGGCAGGTAATGGGCAAGCTG′]

5042
NM_004964.2(HDAC1): c.461A > G
3065
HDAC1
[′GAGGCATCTGGCTTCTGTTACGTCARTGAT

(p.Asn154Ser)

ATCGTCTTGGCCATCCTGGAA′]

5043
NM_014946.3(SPAST): c.1168A > G
6683
SPAST
[′TGGTCCACCTGGGAATGGGAAGACARTGC

(p.Met390Val)

TGGTAAGGGTTCTCTTCAAATT′]

5044
NM_000314.6(PTEN): c.71A > G
5728
PTEN
[′TATCAAGAGGATGGATTCGACTTAGRCTTG

(p.Asp24Gly)

ACCTGTATCCATTTCTGCGGC′]

5045
NM_004380.2(CREBBP): c.4409A >
1387
CREBBP
[′GGGTCCTGCAGGTATGTGACAGGGCRCAT

G (p.His1470Arg)

CTGGGCCTGTCCTCCAAGTGAA′]

5046
NM_018206.4(VPS35): c.1463A > G
55737
VPS35
[′GATCCAGAAGATTTTGCTGATGAGCRGAG

(p.Gln488Arg)

CCTTGTGGGCCGCTTCATTCAT′]

5047
NM_152296.4(ATP1A3): c.971A > G
478
ATP1A3
[′GGCATCATCGTGGCCAATGTCCCAGRGGG

(p.Glu324Gly)

TCTGCTGGCCACTGTCACTGTA′]

5048
NM_172107.2(KCNQ2): c.710A > G
3785
KCNQ2
[′TCTCAGGAGCTGGTCACTGCCTGGTRCATC

(p.Tyr237Cys)

GGCTTCCTTTGTCTCATCCTG′]

5049
NM_001017980.3(VMA21):
203547
VMA21
[′ACTAAATCTTACATATTTGAAGGTARTCTT

c.163 + 4A > G

AGACCCATTAAAACAAGATGT′]

5050
NM_000489.4(ATRX): c.740A > G
546
ATRX
[′TTCTGCAAGAAATGCATTCTACGCARCCTT

(p.Asn247Ser)

GGTCGAAAGGAGTTGTCCACA′]

5051
NM_021147.4(CCNO): c.716A > G
10309
CCNO
[′CCCACCATTAGCTTCTTCCTGGAGCRTTTC

(p.His239Arg)

ACGCACGCTCGCGTGGAGGCG′]

5052
NM_031924.4(RSPH3):
83861
RSPH3
[′CTCTAGAGAATCAGGCCGTCCGAGCYAAC

c.631 − 2A > G

AGTGATAGAAAATACTTCTAGA′]

5053
NM_000069.2(CACNA1S):
779
CACNAIS
[′TCGCTTTCCCATCCTTTTCCTTCCCRGGGCT

c.3526 − 2A > G

ACTTTGGAGACCCCTGGAAT′]

5054
NM_000533.4(PLP1): c.1A > G
5354
PLP1
[′CAATTGGAGTCAGAGTCCCAAAGACRTGG

(p.Met1Val)

GTAAGTTTCAAAAACTTTAGCA′]

5055
NM_207352.3(CYP4V2): c.1396A >
285440
CYP4V2
[′CGTGCCCTTCTCTGCTGGCCCCAGGRACTG

G (p.Asn466Asp)

TATAGGTTTGTATCCATCTGA′]

5056
NM_033409.3(SLC52A3): c.403A >
113278
SLC52A3
[′ACAAAGAAGGTGGTGAGGTAGTAGGYGG

G (p.Thr135Ala)

GCAGCCGGCTCATGAACGGCAGG′]

5057
NM_033409.3(SLC52A3): c.62A > G
113278
SLC52A3
[′CAGGGGCAGCTCTACCCAGAGCCCAYTGA

(p.Asn21Ser)

TGGTCACCCAGGAGCCCATTCC′]

5058
NM_017662.4(TRPM6): c.3173A >
140803
TRPM6
[′CAAGCTGTCTACCTCTTCGTGCAATRTATC

G (p.Tyr1058Cys)

ATCATGGTGAACCTGTTGATT′]

5059
NM_006642.3(SDCCAG8):
10806
SDCCAG8
[′AATAAACCCTCTGCTTTTGCTCTATRGTTA

c.221 − 2A > G

ATCAGCTCAAAGATTTGTTGC′]

5060
NM_022455.4(NSD1): c.5990A > G
64324
NSD1
[′CAAGAACATGATATCACTAATTTCTRTATG

(p.Tyr1997Cys)

CTCACCCTAGACAAAGTAAGT′]

5061
NM_000352.4(ABCC8): c.563A > G
6833
ABCC8
[′GGGATGCTGCTCCTCGTGGAGGTCARTGTC

(p.Asn188Ser)

ATCAGGGTGAGGGTAAGCAGG′]

5062
NM_000275.2(OCA2): c.1427A > G
4948
OCA2
[′GATGGCAGTGGCAGCTCCTCCAATGYTTGT

(p.Asn476Ser)

GAAGATCACTTCTGCAATCAG′]

5063
NM_001848.2(COL6A1):
1291
COL6A1
[′ATTTTCTAGTTTTCTTCCTCTTTCCRGGGGG

c.1003 − 2A > G

AGATGGGGTACCCAGGCCTG′]

5064
NM_003560.2(PLA2G6)
8398
PLA2G6
[′CAGCATGCCCTGCTCTGTGCCTCACRGAAC

c.1349 − 2A > G

TACAGGATCTCATGCACATCT′]

5065
NM_178151.2(DCX): c.280A > G
1641
DCX
[′TGACCTGACGCGATCTCTGTCTGACRACAT

(p.Asn94Asp)

CAACCTGCCTCAGGGAGTGCG′]

5066
NM_000425.4(L1CAM): c.2351A >
3897
LICAM
[′TCCAACACGTCCACCTTCGTGCCCTRTGAG

G (p.Tyr784Cys)

ATCAAAGTCCAGGCCGTCAAC′]

5067
NM_000052.6(ATP7A):
538
ATP7A
[′TCAATGATTATCATTCCTATATTGCRGTTTT

c.2173 − 2A > G

TCGGAGGCTGGTACTTCTAC′]

5068
NM_020247.4(ADCK3): c.1286A >
56997
ADCK3
[′CTGCTGAAGGGCCACCCCTTCTTCTRTGTG

G (p.Tyr429Cys)

CCTGAGATTGTGGATGAGCTC′]

5069
NM_000143.3(FH): c.554A > G
2271
FH
[′AAACAGCAAAGCTCACATACTGACCYGGC

(p.Gln185Arg)

TTTTATTAACATGATCGTTGGG′]

5070
NM_033109.4(PNPT1): c.1453A > G
87178
PNPT1
[′AAACTTCCGCCACATGCAGATGCCAKAGA

(p.Met485Val)

AGATGACCCTATAGAAAGAAAA′]

5071
NM_005888.3(SLC25A3):
5250
SLC25A3
[′TACTTACTTGATTTTTTTTTTTCCARTCAAA

c.158 − 9A > G

CAGAGCAGTATAGCTGTGAC′]

5072
NM_181426.1(CCDC39):
339829
CCDC39
[′TTGTGCTGCTTTATCCAATTCTAACYGTCA

c.610 − 2A > G

AACAGAGAGCAAAGAACATTT′]

5073
NM_153704.5(TMEM67): c.725A >
91147
TMEM67
[′ATTGTTCTGTTGTAGGTATATGCCARTCTA

G (p.Asn242Ser)

ACATCTTGTCAAGCTCTTGGA′]

5074
NM_000166.5(GJB1): c.305A > G
2705
GJB1
[′CACGTGGCTCACCAGCAACACATAGRGAA

(p.Glu102Gly)

GAAAATGCTACGGCTTGAGGGC′]

5075
NM_019098.4(CNGB3): c.1193A >
54714
CNGB3
[′AATTAAAGTTCGAACTGCCCAATAAYAAC

G (p.Tyr398Cys)

ATCTCAGATACCTGTGAAAACA′]

5076
NM_000070.2(CAPN3):
825
CAPN3
[′CCATATGGCTCTCTCTCTTCTTCCARCCTCT

c.1194 − 9A > G

CAGGATGTCCTATGAGGATT′]

5077
NM_002860.3(ALDH18A1):
5832
ALDH18A1
[′AGGAATAGGGAGGTTCTCATGAAGABATT

c.2345A > G (p.Tyr782Cys)

TTAAACTTCCATGCTCTGAGAA′]

5078
NM_001414.3(EIF2B1): c.824A > G
1967
EIF2B1
[′CAGAGTGATTAAGGAAGGGGCAGTGYAGT

(p.Tyr275Cys)

CGACCCACGGATGCTCCTCTTT′]

5079
NM_182896.2(ARL13B): c.461A > G
200894
ARL13B
[′TGTCTATCTCTGGAAAAATTGGTCARTGAG

(p.Asn154Ser)

CACAAGTGCCTGTGTCAGATA′]

5080
NM_001134831.1(AHI1):
54806
AHI1
[′TAGTAAGATGAAACAGGCCGTCCACYGTA

c.1152 − 2A > G

CAAAAAAAGATACTTCCATTAA′]

5081
NM_153704.5(TMEM67):
91147
TMEM67
[′TCAGTTTTAAAGGAGAAAACCAGGTRAAA

c.978 + 3A > G

GTGTCTAATATCATTAGAGGAT′]

5082
NM_015681.3(B9D1): c.95A > G
27077
B9D1
[′CCAGTCCTGGCCGTACACAAAGCAGYACT

(p.Tyr32Cys)

TGCAGTAGAGGTCATCATACTC′]

5083
NM_014049.4(ACAD9): c.1A > G
28976
ACAD9
[′CTGAGGCTGGGGAACATCGGGCAGCWTGA

(p.Met1Val)

GCGGCTGCGGGCTCTTCCTGCG′]

TABLE 8

xCas9v3 Mutations (K294R/Q1256K Series)

xCas9 3.0
xCas9 3.1
xCas9 3.2
xCas9 3.3
xCas9 3.4

N175T

P230F

D257N

S267G

S267G
S267G

K294R
K294R
K294R
K294R
K294R

T466A

E480K
E480K
E480K
E480K
E480K

E543D
E543D
E543D
E543D
E543D

A711E

E1207G

I1063V

E1219V
E1219V
E1219V
E1219V
E1219V

Q1256K
Q1256K
Q1256K
Q1256K
Q1256K

TABLE 9

xCas9v3 Mutations (A262T/S409I Series)

xCas9 3.5
xCas9 3.6
xCas9 3.7
xCas9 3.8
xCas9 3.9
xCas9 3.10
xCas9 3.11
xCas9 3.12

E108G
E108G

E108G
E108G

S217A

A262T
A262T
A262T
A262T
A262T
A262T
A262T
A262T

R324L

S409I
S409I
S409I
S409I
S409I
S409I
S409I
S409I

E480K
E480K
E480K
E480K
E480K
E480K
E480K
E480K

E543D
E543D
E543D
E543D
E543D
E543D
E543D
E543D

D605D
D605D

K673E

K673E

M694I
M694I
M694I
M694I
M694I
M694I
M694I
M694I

E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V
E1219V

H1264Y

L1365I
L1365I

L1365I

L1365I

TABLE 10

PAM Depletion Scores (xCas9v3.0-3.6 Mutations)

22-4
22-10
22-11
22-14
22-21
22-65
22-66

xCas9
xCas9
xCas9
xCas9
xCas9
xCas9
xCas9

3.0
3.1
3.2
3.3
3.4
3.5
3.6

AAA
0.61
0.69
1.38
0.90
0.98
1.29
1.47

AAC
0.67
0.77
0.78
0.71
0.93
0.80
1.55

AAG
13.88
15.70
32.70
28.75
22.79
48.60
92.02

AAT
0.52
0.59
0.87
0.63
0.76
0.87
0.84

ACA
0.52
0.52
0.48
0.51
0.57
0.59
0.72

ACC
0.54
0.50
0.48
0.48
0.47
0.46
0.55

ACG
10.15
30.07
41.38
108.50
32.19
25.52
158.44

ACT
0.46
0.47
0.39
0.41
0.44
0.40
0.50

AGA
13.22
28.30
34.42
57.31
38.26
31.93
170.85

AGC
7.55
5.84
11.17
8.69
7.63
13.13
5.54

AGG
12.23
188.82
37.97
182.49
194.93
82.99
355.32

AGT
13.19
9.75
17.03
16.09
10.90
19.84
22.47

ATA
0.58
0.56
0.51
0.52
0.51
0.53
0.49

ATC
0.52
0.50
0.45
0.45
0.47
0.42
0.38

ATG
11.38
14.85
23.55
40.11
20.48
30.27
108.77

ATT
0.48
0.46
0.43
0.42
0.43
0.41
0.39

CAA
1.55
2.00
6.63
5.06
3.42
6.29
4.66

CAC
0.57
0.65
0.99
0.75
0.86
0.93
3.20

CAG
15.05
11.83
26.90
26.86
22.15
32.07
137.31

CAT
4.41
6.06
17.67
7.55
6.30
8.13
7.87

CCA
0.48
0.46
0.41
0.43
0.42
0.40
0.39

CCC
0.53
0.51
0.46
0.45
0.45
0.43
0.44

CCG
3.35
2.67
6.87
6.98
4.69
8.56
5.44

CCT
0.53
0.50
0.45
0.49
0.46
0.43
0.38

CGA
9.23
49.45
43.50
106.20
62.04
27.17
116.32

CGC
13.79
8.59
17.62
15.06
12.16
21.40
11.61

CGG
16.85
223.84
46.41
346.14
96.28
90.82
252.73

CGT
12.66
23.87
36.06
42.02
20.18
27.33
179.69

CTA
0.54
0.50
0.45
0.47
0.47
0.45
0.49

CTC
0.51
0.48
0.43
0.44
0.45
0.42
0.38

CTG
5.39
3.40
6.92
8.28
5.95
11.34
4.20

CTT
0.52
0.52
0.46
0.46
0.44
0.44
0.82

GAA
10.98
7.67
14.45
11.25
9.75
11.86
6.86

GAC
0.88
1.35
4.85
2.92
2.40
5.25
4.15

GAG
11.85
55.33
39.91
118.83
109.84
85.83
390.44

GAT
7.69
5.68
10.55
9.22
6.41
11.03
9.53

GCA
0.49
0.49
0.47
0.52
0.53
0.59
0.61

GCC
0.53
0.52
0.50
0.50
0.49
0.46
0.52

GCG
13.68
13.44
22.56
46.72
32.75
35.86
97.69

GCT
0.51
0.50
0.45
0.48
0.46
0.45
0.61

GGA
9.74
82.32
39.45
172.39
102.30
85.53
77.46

GGC
12.21
10.04
17.84
15.18
14.04
27.07
17.46

GGG
18.90
381.76
70.36
281.12
164.21
111.87
718.40

GGT
10.87
22.11
32.25
88.31
40.66
40.16
257.92

GTA
0.56
0.59
0.77
0.72
0.76
1.03
1.55

GTC
0.52
0.51
0.46
0.52
0.49
0.45
0.58

GTG
11.43
16.42
28.54
72.25
33.31
47.65
382.48

GTT
0.48
0.45
0.41
0.43
0.43
0.42
0.76

TAA
0.58
0.67
1.59
0.99
1.04
1.69
1.53

TAC
0.56
0.54
0.51
0.51
0.52
0.50
0.44

TAG
11.34
10.19
15.99
22.04
15.24
27.89
35.59

TAT
0.56
0.64
1.26
0.85
0.89
1.21
2.60

TCA
0.50
0.48
0.43
0.45
0.46
0.45
0.44

TCC
0.50
0.48
0.43
0.46
0.44
0.42
0.47

TCG
10.38
8.24
14.95
15.64
9.96
15.57
34.80

TCT
0.52
0.50
0.45
0.44
0.46
0.41
0.46

TGA
9.68
61.64
44.45
188.12
99.42
46.89
186.41

TGC
13.64
9.07
15.11
11.69
11.22
15.01
8.15

TGG
12.90
223.88
63.67
259.65
115.56
80.51
210.65

TGT
11.53
18.90
31.99
36.30
18.72
21.90
122.87

TTA
0.61
0.57
0.52
0.54
0.51
0.52
0.30

TTC
0.53
0.50
0.44
0.45
0.44
0.43
0.27

TTG
13.57
6.61
10.15
13.27
7.38
14.26
12.24

TTT
0.53
0.49
0.44
0.45
0.48
0.44
0.28

PAM Depletion Scores (xCas9v3.7-3.12 Mutations)

22-68
22-75
22-78
22-82
22-87
22-90

xCas9
xCas9
xCas9
xCas9
xCas9
xCas9

3.7
3.8
3.9
3.10
3.11
3.12

AAA
0.92
1.00
4.30
0.63
0.48
1.67

AAC
8.72
3.59
1.55
1.59
0.94
1.34

AAG
23.44
20.16
16.46
10.63
26.46
22.44

AAT
1.03
0.89
1.22
1.07
0.76
0.96

ACA
0.80
0.92
0.52
0.68
1.09
0.83

ACC
0.42
1.37
0.32
1.03
0.81
0.53

ACG
11.20
6.65
21.80
1.38
1.23
0.88

ACT
0.27
0.38
0.24
0.88
0.54
0.66

AGA
11.63
11.95
14.60
0.89
1.42
1.78

AGC
1.03
11.25
8.05
1.54
1.77
2.39

AGG
8.05
11.61
21.28
1.37
33.28
113.98

AGT
11.10
6.85
12.73
0.39
2.70
0.91

ATA
0.73
0.79
0.58
1.04
0.70
0.94

ATC
0.43
0.47
0.28
0.63
0.86
0.87

ATG
15.46
13.03
4.76
2.21
2.39
1.73

ATT
0.62
0.30
0.53
0.59
0.91
0.74

CAA
8.96
6.08
1.97
1.46
0.53
0.67

CAC
1.65
1.31
0.81
0.60
0.75
0.73

CAG
3.46
1.99
1.44
23.50
9.51
13.76

CAT
20.52
44.57
18.70
16.29
15.96
0.36

CCA
0.40
0.31
0.64
0.87
0.55
0.64

CCC
0.35
0.54
0.55
1.12
0.56
0.69

CCG
4.35
5.28
5.57
1.37
0.94
0.8

CCT
0.40
1.04
0.36
1.22
0.67
0.59

CGA
4.47
7.60
5.26
1.35
1.36
2.02

CGC
13.35
10.98
5.45
4.03
5.37
3.66

CGG
6.06
5.52
25.23
31.85
19.44
34.65

CGT
17.13
7.41
17.31
0.63
1.44
0.66

CTA
0.76
0.50
0.50
1.97
1.45
1.05

CTC
0.40
0.26
0.65
0.58
0.45
0.81

CTG
5.64
9.49
6.82
1.35
1.41
2.11

CTT
0.50
0.63
0.68
0.54
0.73
0.88

GAA
9.81
6.07
4.68
2.07
0.87
1.09

GAC
3.91
3.95
2.82
0.44
0.86
0.56

GAG
23.26
21.32
9.88
16.93
18.42
40.73

GAT
5.06
9.85
1.07
0.75
1.06
0.63

GCA
0.56
0.81
0.79
1.46
0.44
0.89

GCC
0.35
0.52
0.71
0.65
3.67
0.73

GCG
16.11
12.53
9.43
1.59
1.98
2.22

GCT
0.42
0.88
0.27
0.66
1.14
0.76

GGA
3.01
18.40
33.07
27.28
16.20
46.82

GGC
6.03
3.83
11.69
8.03
22.56
3.92

GGG
12.16
10.26
15.08
17.30
25.85
128.03

GGT
11.25
13.77
2.94
12.71
16.11
16.22

GTA
1.38
1.08
1.24
0.75
3.52
1.09

GTC
0.96
0.31
0.50
0.93
0.72
0.81

GTG
6.68
17.93
26.86
9.93
9.61
2.72

GTT
0.45
0.33
0.99
0.65
1.61
1.01

TAA
3.04
2.16
1.84
1.21
1.08
0.68

TAC
0.61
0.52
0.68
0.95
0.68
0.86

TAG
4.76
15.71
1.10
8.15
8.25
8.87

TAT
1.62
2.10
1.01
0.73
0.74
0.66

TCA
0.41
0.66
0.58
0.46
0.77
0.68

TCC
0.54
0.29
0.38
1.36
0.86
0.82

TCG
1.41
4.20
9.11
0.84
0.46
0.69

TCT
0.47
0.44
0.38
0.60
1.00
0.94

TGA
22.42
5.39
15.72
1.78
3.13
3.69

TGC
6.78
6.81
11.35
2.4
6.55
4.08

TGG
20.36
11.36
11.56
9.97
21.64
19.87

TGT
10.32
8.82
21.17
0.94
0.79
0.73

TTA
0.65
0.29
0.77
0.94
1.35
0.75

TTC
0.62
1.07
0.55
0.86
1.07
0.58

TTG
8.41
6.07
9.07
0.67
0.56
0.72

TTT
0.43
0.56
0.44
0.68
0.60
0.75

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All publications, patents, patent applications, publication, and database entries (e.g., sequence database entries) mentioned herein, e.g., in the Background, Summary, Detailed Description, Examples, and/or References sections, are hereby incorporated by reference in their entirety as if each individual publication, patent, patent application, publication, and database entry was specifically and individually incorporated herein by reference. In case of conflict, the present application, including any definitions herein, will control.

EQUIVALENTS AND SCOPE

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents of the embodiments described herein. The scope of the present disclosure is not intended to be limited to the above description, but rather is as set forth in the appended claims.

Articles such as “a,” “an,” and “the” may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include “or” between two or more members of a group are considered satisfied if one, more than one, or all of the group members are present, unless indicated to the contrary or otherwise evident from the context. The disclosure of a group that includes “or” between two or more group members provides embodiments in which exactly one member of the group is present, embodiments in which more than one members of the group are present, and embodiments in which all of the group members are present. For purposes of brevity those embodiments have not been individually spelled out herein, but it will be understood that each of these embodiments is provided herein and may be specifically claimed or disclaimed.

It is to be understood that the invention encompasses all variations, combinations, and permutations in which one or more limitation, element, clause, or descriptive term, from one or more of the claims or from one or more relevant portion of the description, is introduced into another claim. For example, a claim that is dependent on another claim can be modified to include one or more of the limitations found in any other claim that is dependent on the same base claim. Furthermore, where the claims recite a composition, it is to be understood that methods of making or using the composition according to any of the methods of making or using disclosed herein or according to methods known in the art, if any, are included, unless otherwise indicated or unless it would be evident to one of ordinary skill in the art that a contradiction or inconsistency would arise.

Where elements are presented as lists, e.g., in Markush group format, it is to be understood that every possible subgroup of the elements is also disclosed, and that any element or subgroup of elements can be removed from the group. It is also noted that the term “comprising” is intended to be open and permits the inclusion of additional elements or steps. It should be understood that, in general, where an embodiment, product, or method is referred to as comprising particular elements, features, or steps, embodiments, products, or methods that consist, or consist essentially of, such elements, features, or steps, are provided as well. For purposes of brevity those embodiments have not been individually spelled out herein, but it will be understood that each of these embodiments is provided herein and may be specifically claimed or disclaimed.

Where ranges are given, endpoints are included. Furthermore, it is to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value within the stated ranges in some embodiments, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise. For purposes of brevity, the values in each range have not been individually spelled out herein, but it will be understood that each of these values is provided herein and may be specifically claimed or disclaimed. It is also to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values expressed as ranges can assume any subrange within the given range, wherein the endpoints of the subrange are expressed to the same degree of accuracy as the tenth of the unit of the lower limit of the range.

In addition, it is to be understood that any particular embodiment of the present invention may be explicitly excluded from any one or more of the claims. Where ranges are given, any value within the range may explicitly be excluded from any one or more of the claims. Any embodiment, element, feature, application, or aspect of the compositions and/or methods of the invention, can be excluded from any one or more claims. For purposes of brevity, all of the embodiments in which one or more elements, features, purposes, or aspects is excluded are not set forth explicitly herein.

Number	Date	Country
62408686	Oct 2016	US
62398490	Sep 2016	US
62370700	Aug 2016	US
62357352	Jun 2016	US
62357332	Jun 2016	US
62322178	Apr 2016	US
62311763	Mar 2016	US
62279346	Jan 2016	US
62245828	Oct 2015	US

	Number	Date	Country
Parent	15770076	Apr 2018	US
Child	18732559		US

EVOLVED CAS9 PROTEINS FOR GENE EDITING

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