Agarwala, Neena, et al., "Specific Binding of Parathyroid Hormone to Living Osteoclasts", Journal of Bone and Mineral Research, 7:531-539, 1992. |
Bonadio et al., "Transgenic mouse model of the mild dominant form of osteogenesis imperfecta," Proc. Natl. Acad. Sci. USA, 87:7145-7149, 1990. |
Davidson et al., "A model system for in vivo gene transfer into the central nervous system using an adenoviral vector," Nature Genetics, 3:219-223, 1993. |
Falcone et al., "Macrophage and Foam Cell Release of Matrix-bound Growth Factors," The Journal of Biological Chemistry, 268(15) :11951-11958, 1993. |
Flaumenhaft et al., "Role of the Latent TGF-.beta. Binding Protein in the Activation of Latent TGF-.beta. by Co-Cultures of Endothelial and Smooth Muscle Cells," The Journal of Cell Biology, 120(4) :995-1002, 1993. |
Majmudar et al., "Bone Cell Culture in a Three-Dimensional Polymer Bead Stabilizes the Differentiated Phenotype and Provides Evidence That Osteoblastic Cells Synthesize Type III Collagen and Fibronectin," Journal of Bone and Mineral Research, 6(8) :869-881, 1991. |
Miyazono et al., "Retention of the Transforming Growth Factor-.beta.1 Precursor in the Golgi Complex in a Latent Endoglycosidase H-sensitive Form," The Journal of Biological Chemistry, 267(8) :5668-5675, 1992. |
Pereira et al., "Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome," Human Molecular Genetics, 2(7) :961-968, 1993. |
Seitz et al., "Effect of Transforming Growth Factor .beta. on Parathyroid Hormone Receptor Binding and cAMP Formation in Rat Osteosarcoma Cells", Journal of Bone and Mineral Research, 7:541-546, 1992. |
Alper, 1994, "Boning Up: Newly Isolated Proteins Heal Bad Breaks", Science 263:324-325. |
Bandara, G. et al., 1992, "Gene Transfer to Synoviocytes: Prospects for Gene Treatment of Arthritis", DNA and Cell Biol. 11(3):227-231. |
Beck, L.S. et al., 1991, "Rapid Publication of TGF-.beta.1 Induces Bone Closure of Skull Defects", J. Bone Miner, Res. 6(11):1257-1265. |
Boden, S.D. et al., 1989, "Estrogen Receptor mRNA Expression in Callus During Fracture Healing in the Rat", Calcif. Tissue Int. 45:324-325. |
Bonnarens and Einhorn, 1984, "Production of a Standard Closed Fracture in Laboratory Animal Bone", J. Orthop. Res. 2:97-101. |
Carrington, J.L. et al., 1988, "Accumulation, Localization and Compartmentalization of Transforming Growth Factor .beta. During Endochondral Bone Development", J. Cell. Biol. 107:1969-1975. |
Centrella, M. et al., 1988, "Skeletal Tissue and Transforming Growth Factor .beta.", FASEB J. 2:3066-3073. |
Chen, T.L. et al., 1991, "Bone Morphogenetic Protein-2b Stimulation of Growth and Osteogenic Phenotypes in Rat Osteoblast-like Cells: Comparison with TGF-.beta.1", J. Bone Miner. Res. 6(12):1387-1393. |
Cunningham, N.S. et al., 1992, "Osteogenin and Recombinant Bone Morphogenetic Protein 2B are Chemotactic for Human Monocytes and Stimulate Transforming Growth Factor .beta.1 mRNA Expression", Proc. Natl. Acad. Sci. USA 89:11740-11744. |
Gunasekaran, S. et al., 1993, "Mineralized Collagen as a Substitute for Autograft Bone that can Deliver Bone Morphogenic Protein", The 19th Annual Meeting of the Society for Biomaterials, p. 253. |
Gunasekaran, S., 1993, "Role of Mineralized Collagen as an Osteoconductive Biomaterial", The 19th Annual Meeting of the Society for Biomaterials, p. 161. |
Gunasekaran, S. et al., "Mineralization of Collagen Without Nucleating Proteins", 11:30 AM, V7.5, p.426. |
Horowitz, M.C. et al., 1989, "Functional and Molecular Changes in Colony Stimulating Factor Secretion by Osteoblasts", Connective Tissue Res. 20:159-168. |
Huggins, C.B. et al., 1936, "Experiments on the Theory of Osteogenesis", Arch. Surg. 32(6):915-931. |
Izumi, T. et al., 1992, "Transforming Growth Factor .beta.1 Stimulates Type II Collagen Expression in Cultured Periosteum-Derived Cells", J. Bone Miner. Res. 7(1):115-121. |
Jingushi, S. et al., 1992, "Genetic Expression of Extracellular Matrix Proteins Correlates with Histologic Changes During Fracture Repair", J. Bone Miner. Res. 7(9):1045-1055. |
Jingushi, S. et al., 1990, "Acidic Fibroblast Growth Factor (aFGF) Injection Stimulates Cartilage Enlargement and Inhibits Cartilage Gene Expression in Rat Fracture Healing", J. Orthop. Res. 8:364-371. |
Joyce, M.E. et al., 1991, "Role of Growth Factors in Fracture Healing", Clinical and Experimental Approaches to Dermal and Epidermal Repair: Normal and Chronic Wounds, Proceedings of the Third International Symposium on Tissue Repair, Miami, FL, Jan. 10-14, 1990, Wiley-Liss, NY, NY pp. 391-416. |
Joyce, M.E. et al., 1990, "Transforming Growth Factor-.beta.and the Initiation of Chondrogenesis and Osteogenesis in the Rat Femur", J. Cell Biol. 110:2195-2207. |
Luyten, F.P. et al., 1989, "Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation", J. Biol. Chem. 264(23):13377-13380. |
O'Malley, Jr. and Ledley, 1993, "Somatic Gene Therapy in Otolaryngology-Head and Neck Surgery" Arch. Otolaryngol. Head Neck Surg. 119:1191-1197. |
Ozkaynak, E. et al., 1990, "Op-1 cDNA Encodes an Osteogenic Protein in the TFG-.beta. Family", EMBO J. 9(7):2085-2093. |
Paralkar, V.M. et al., 1991, "Identification and Characterization of Cellular Binding Proteins (Receptors) for Recombinant Human Bone Morphogenetic Protein 2B, a Initiator of Bone Differentiation Cascade", Proc. Natl. Acad. Sci. USA 88:3397-3401. |
Roessier, B.J. et al., 1993, "Adenoviral-Mediated Gene Transfer to Rabbit Synovium in Vivo", J. Clin. Invest. 92:1085-1092. |
Rosen, V. et al., 1989, "Purification and Molecular Cloning of a Novel Group of BMPs and Localization of BMP mRNA in Developing Bone", Connect. Tissue Res. 20:313-319. |
Sampath, T.K. et al., 1984, "In Vitro Transformation of Mesenchymal Cells Derived From Embryonic Muscle into Cartilage in Response to Extracellular Matrix Components of Bone", Proc. Natl. Acad. Sci. USA 81:3419-3423. |
Sampath and Reddy, 1981, "Dissociative Extraction and Reconstitution of Extracellular Matrix Components Involved in Local Bone Differentiation", Proc. Natl. Acad Sci. USA 78(12):7599-7603. |
Sandusky, Jr., G.E. et al., 1992, "Histologic Findings After In Vivo Placement of Small Intestine Submucosal Vascular Grafts and Saphenous Vein Grafts in the Carotid Artery in Dogs", Am. J. Pathol. 140(2):317-324. |
Shimell, M. et al., 1991, "The Drosophila Dorsal-Ventral Patterning Gene tolloid is Related to Human Bone Morphogenetic Protein 1", Cell 67:469-481. |
Srivastava, C.H. et al., 1989, "Construction of a Recombinant Human Parvovirus B19: Adenoassociated Virus 2 (AAV) DNA Inverted Terminal Repeats are Functional in an AAV-B19 Hybrid Virus", Proc. Natl. Sci. USA 86:8078-8082. |
Ulmer, J.B. et al., 1993, "Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein", Science 259:1745-1749. |
Urist, M.R. et al., 1983, "Bone Cell Differentiation Growth Factors", Science 220:680-686. |
Urist, M.R., 1965, "Bone: Formation by Autoinduction", Science 150:893-899. |
Wang, E.A. et al., 1990, "Recombinant Human Bone Morphogenetic Protein Induces Bone Formation", Proc. Natl. Acad. Sci. USA 87:2220-2224. |
Wilson, J.M. et al., "Somatic Gene Transfer in the Development of an Animal Model for Primary Hyperparathyroidism", Endocrinology 130(5):2947-2954. |
Wolff, J.A. et al., 1990, "Direct Gene Transfer into Mouse Muscle in Vivo"Science 247:1465-1468. |
Wozney, J.M. et al., 1988, "Novel Regulators of Bone Formation: Molecular Clones and Activities" Science 242:1528-1534. |
Yasko, A.W. et al., 1992, "The Healing of Segmental Bone Defects, Induced by Recombinant Human Bone Morphogenetic Protein (rhBMP-2)", J. Bone and Joint Surg. 74-A(5):659-670. |
Agarwala, N. et al., 1992, Specific Binding of Parathyroid Hormone to Living Osteoclasts:. J. Bone Miner. Res. 7:531-539. |
Bonadio et al., 1990, "Transgenic Mouse Model of the Mild Dominant Form of Osteogenesis Imperfecta", Proc. Natl. Acad. Sci. USA 87:7145-7149. |
Davidson et al., 1993, "A Model System for in Vivo Gene Transfer into the Central Nervous System Using an Adenoviral Vector", Nature Genetics 3:219-223. |
Falcone et al., 1993, "Macrophage and Foam Cell Release of Matrix-Bound Growth Factors", J. Biol. Chem. 268(15):11951-11958. |
Flaumenhaft et al., 1993, "Role of the Latent TGF-.beta. Binding Protein in the Activation of Latent TGF-.beta. by Co-Cultures of Endothelial and Smooth Muscle Cells.", J. Cell Biol. 120(4):995-1002. |
Majmudar et al., 1991, "Bone Cell Culture in a Three-Dimensional Polymer Bead Stabilizes the Differentiated Phenotype and Provides Evidence that Osteoblastic Cells Synthesize Type III Collagen and Fibronectin" J. Bone Miner. Res. 6(8):869-881. |
Miyazono et al., 1992, "Retention of the Transforming Growth Factor-.beta.1 Precursor in the Golgi Complex in a Latent Endoglycosidase H-Sensitive Form" J. Biol. Chem. 267(8):5668-5675. |
Pereira et al., 1993, "Genomic Organization of the Sequence Coding for Fibrillin, the Defective Gene Product in Marfan Syndrome", Hum. Mol. Genet. 2(7):961-968. |
Seitz et al., 1992, Effect of Transforming Growth Factor .beta. on Parathyroid Hormone Receptor Binding and cAMP Formation in Rat Osteosarcoma Cells, J. Bone Miner. Res. 7:541-546. |
Selander-Sunnerhagen et al., 1992, "How an Epidermal Growth Factor (EGF)-Like Domain Binds Calcium", J. Biol. Chem. 267(27):19642-19649. |
Steiner et al., 1992, "The New Enzymology of Precursor Processing Endoproteases", J. Biol. Chem. 267(33):23435-23438. |
Stratford-Perricaudet et al., 1992, "Widespread Long-Term Gene Transfer to Mouse Skeletal Muscles and Heart", J. Clin. Invest. 90:626-630. |
Rosen and Thies, 1992, "The BMP Proteins in Bone Formation and Repair", Trends in Genetics 8(3):97-102. |
International Search Report from WO95/22611. |
Badylak et al., 1992, "Directed Connective Tissue Remodeling Upon a Biologic Collagen Substrate". J. Cell. Biochem. Suppl. 16F:124. |
Benevisty and Reshef, 1986, "Direct Introduction of Genes into Rats and Expression of the Genes", Proc. Natl. Acad. Sci. USA 83:9551-9555. |
Bonadio, J. and Goldstein, S., 1994, "Direct Gene Transfer into Skeletal Tissue in Vivo", Gene Therapy Meeting: Cold Spring Harbor, Conference Abstract, Sep. 21-25. |
Edelman et al., 1995, "c-myc in Vasculoproliferative Disease" Circulation Res. 76(2):1.2-1.8. |
Evans and Robbins, 1995, "Possible Orthopaedic Applications of Gene Therapy", J. Bone and Joint Surg. 77-A(7):1103-1114. |
Indolfi et al., 1995, "Inhibition of Cellular ras Prevents Smooth Muscle Cell Proliferation After Vascular Injury in vivo", Nature Medicine 1(16):541-545. |
Badylak, S., Bonadio, J and Voytik, S., Invention Disclosure entitled: "Small Intestinal Submucosa as Biomaterial to Promote Gene Transfer", Sep. 4, 1992. |
Kaneda et al., 1989, "Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver", Science 243:375-378. |
Mannino and Gould-Fogerite, 1988, "Liposome Mediated Gene Transfer"BioTechniques 6(7):682-690. |
Mumper et al., 1995, "Interactive Polymeric Gene Delivery Systems for Enhanced Muscle Expression", Abstract, Amer. Assoc. of Pharmaceutical Science, Miami Beach, FL, Nov. 6-9, 1995. |
Nicolau et al., 1983, "In Vivo Expression of Rat Insulin After Intravenous Administration of the Liposome-Entrapped Gene for Rat Insulin I"Proc. Natl. Acad. Sci USA 80:1068-1072. |
Simons et al., 1992, "Antisense c-myb Oligonucleotides Inhibit Intimal Arterial Smooth Muscle Cell Accumulation in Vivo", Nature 359:67-70. |
Sumner et al., 1995, "Enhancement of Bone Ingrowth by Transforming Growth Factor-.beta.", J. Bone and Joint Surg. 77-A(8):1135-1147. |
Wolfe et al., 1991, "Conditions Affecting Direct Gene Transfer into Rodent Muscle in Vivo", BioTechniques 11(4):474-485. |
Wu and Wu, 1988, "Receptor-Mediated Gene Delivery and Expression in Vivo", J. Biol. Chem. 263(29):14621-14624. |
Yin et al., 1994, "Molecular Cloning of a Novel Fibrillin-Like cDNA: Expression in Callus Tissue as Alternatively Spliced Transcripts", 40th Annual Meeting, Orthopaedic Research Society, Conference Abstract, Feb. 21-24, 1994. |
Zhu et al., 1994, "Direct Gene Transfer into Regenerating Achilles' Tendon", 40th Annual Meeting, Orthopaedic Research Society, Conference Abstract, Feb. 21-24, 1994. |
U.S. Patent Application Serial No. 08/176,565, filed Jan. 03, 1994, entitled "Fluidized Intestinal Submucosa and its Use as an Injectable Tissue Graft". |
U.S. Patent Application Serial No. 08/343,204, filed Nov. 22, 1994, entitled "Fluidized Intestinal Submucosa and its Use as an Injectable Tissue Graft". |
U.S. Patent Application Serial No. 08/390,700, filed Feb. 17, 1995, entitled "Compositions and Method for Production of Transformed Cells". |
U.S. Patent Application Serial No. 08/386,432, filed Feb. 10, 1995, entitled "Bone Graft Composition". |
U.S. Patent Application Serial No. 08/386,452, filed Feb. 10, 1995, entitled "Submucosa as a Growth Substrate for Cells". |
Ledley, F.D., 1987, "Somatic gene Therapy for Human Disease: Background and Prospects. Part I", J. Pediatrics 110(1):1-8. |
James Wilson et al., Endocrinology, vol. 30, 5:2947-2954. |
Matthews et al (Experimental Hematology 21:697-702, 1993). |
Rosen and Thies, "The BMP proteins in bone formation and repair," Trends in Genetics, 8(3) :97-102, Mar. 1992. |
International Search Report dated Sep. 15, 1995. |
Nicolau et al., "In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I," Proc. Natl. Acad. Sci. USA, 80:1068-1072, Feb., 1983. |
Simons et al., "Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo," Nature, 359:67-70, Sep., 1992. |
Sumner et al., "Enhancement of Bone Ingrowth by Transforming Growth Factor-.beta.," The Journal of Bone and Joint Surgery, 77-A(8):1135-1147, Aug., 1995. |
Wolff et al., "Conditions Affecting Direct Gene Transfer into Rodent Muscle In Vivo," BioTechniques, 11(4): 474-485, 1991. |
Wolff et al., "Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle," Journal of Cell Science, 103:1249-1259, 1992. |
Indolfi et al., "Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo," Nature Medicine, 1(6):541-545, Jun., 1995. |
Invention Disclosure entitled "Small Intestinal Submucosa as Biomaterial to Promote Gene Transfer," Stephen G. Badylak, Jeffrey Bonadio and Sherry L. Voytik, Sep. 4, 1992. |
Kaneda et al., "Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver," Science, 243:375-378, Jan., 1989. |
Mannino and Gould-Fogerite, "Liposome Mediated Gene Transfer," BioTechniques, 6(7):682-690, 1988. |
Mumper et al., "Interactive Polymeric Gene Delivery Systems for Enhanced Muscle Expression," Abstract, American Assoc. of Pharmaceutical Science, Miami Beach, FL, Nov. 6-9, 1995. |
Badylak et al., "Directed Connective Tissue Remodeling Upon a Biologic Collagen Substrate," J. Cell Biochem. Supplement 16F, p. 124, Apr. 3-16, 1992. |
Benevisty and Reshef, "Direct introduction of genes into rats and expression of the genes," Proc. Natl. Acad. Sci. USA, 83:9551-9555, Dec, 1986. |
Bonadio and Goldstein, "Direct Gene Transfer into Skeletal Tissues In Vivo,"Gene Therapy Meeting: Cold Spring Harbor, Conference Abstract, Sep. 21-25, 1994. |
Edelman et al., "c-myc in Vasculoproliferative Disease," Circulation Research, 76(2):1.2-1.8, Feb., 1995. |
Evans and Robbins, "Possible Orthopaedic Applications of Gene Therapy," The Journal of Bone and Joint Surgery, 77-A(7):1103-1114, Jul., 1995. |
U.S. Patent Application Serial No. 08/386,432; filed Feb. 10, 1995; entitled "Bone Graft Composition". |
U.S. Patent Application Serial No. 08/386,452; filed Feb. 10, 1995; entitled "Submucosa as a Growth Substrate for Cells.". |
Wu and Wu, "Receptor-mediated Gene Delivery and Expression in Vivo," The Journal of Biological Chemistry, 263(29):14621-14624, 1988. |
Yin et al., "Molecular Cloning of a Novel Fibrillin-Like cDNA: Expression in Callus Tissue as Alternatively Spliced Transcripts," 40th Annual Meeting, Orthopaedic Research Society, Conference Abstract, Feb. 21-24, 1994. |
Zhu et al., "Direct Gene Transfer into Regenerating Achilles' Tendon," 40th Annual Meeting, Orthopaedic Research Society, Conference Abstract, Feb. 21-24, 1994. |
U.S. Patent Application Serial No. 08/176,565; filed Jan. 03, 1994; entitled "Fluidized Intestinal Submucosa and its Use as an Injectable Tissue Graft". |
U.S. Patent Application Serial No. 08/343,204; filed Nov. 22, 1994; entitled "Fluidized Intestinal Submucosa and its Use as an Injectable Tissue Graft". |
U.S. Patent Application Serial No. 08/390,700; filed Feb. 17, 1995; entitled "Compositions and Method for Production of Transformed Cells". |