Patent Grant
8487239
The present invention relates to the field of mass spectrometry.
Ion sources are an important part of the mass spectrometer. Mass spectrometers can only produce results of what is input into the instrument. If the ion source is very inefficient, which means that very few sample ions are produced, the mass spectrometer will also be inefficient. Equally, if the ion source produces too many ions from solvent or other impurities in the instrument noise produced within the instrument may reduce the potential performance.
Ion sources produce greater numbers of sample ions at higher temperatures. However, they will also produce more noise ions at higher temperatures too. These high temperatures also result in the access to source enclosures needing to be restricted for compliance with regulatory requirements. To date, this has been achieved by the use of additional instrument panels.
It would therefore be desirable to produce an ion source that can be regulated to be at the optimum temperature within the ion source, but for the external face of the source to be at room or at least at a safe temperature to touch.
One aspect of the present invention provides a method of enhancing the performance of an ion source for use with a mass spectrometer which ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber and wherein a fluid flow passageway is provided between the ion source enclosure and the outer cover, the method comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60° c. and 80° c. Preferably, the predetermined temperature range is approximately 70° c.
Another aspect of the present invention provides an ion source housing for use with a mass spectrometer which housing incorporates an ion source enclosure defining a chamber and an outer cover remote from the chamber and wherein a fluid flow passageway is provided between the ion source enclosure and the outer cover which passageway has an inlet and at least one outlet positioned so as to encourage an efficient flow of fluid through said fluid flow passageway in order to maintain the ion source enclosure within a predetermined temperature range of substantially between 60 c and 80 c. Preferably, the fluid flow passageway incorporates a heat sink.
Yet another aspect of the present invention provides a mass spectrometer having an ion source enclosure according to the immediately preceding paragraph wherein the ion source has mounting means complementary to mounting means provided by the mass spectrometer to detachably couple the ion source with said mass spectrometer and to allow movement of the housing to bring the ion source chamber into position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position, and a release mechanism that cooperates with said mass spectrometer to allow said movement of said housing. Preferably, the ion source mounting and the complementary mass spectrometer mounting together allow pivotal movement of the ion source housing towards and away from the inlet of said mass spectrometer. Preferably, the ion source mounting and the complementary mass spectrometer mounting together allow translatory movement of the ion source housing when in the retracted position in a direction along the axis of said pivotal movement to allow detachment and replacement of the ion source housing with respect to said inlet of the mass spectrometer.
According to a further feature of this aspect of the invention, pressure sensor means may be provided to allow continuous monitoring of source pressure and periodic leak checking of the source enclosure and wherein the pressure sensor means may be adapted to actuate a pressure check valve to prevent potentially dangerous source over-pressurization occurring in fault conditions. Preferably, the pressure sensor means is operatively connected to an atmospheric pressure ionization (API) solenoid which is adapted to close at a predetermined pressure to protect the pressure sensor means. It also is preferred that an exhaust isolation valve is provided and operative in the event that API gas is not present to prevent migration of external gases into the ion source.
According to yet another feature of this aspect of the invention, sealing means may be provided to create an air tight seal between said housing and said mass spectrometer when the ion source chamber is in said position of use.
Various embodiments of the present invention will now be described, by way of example only, and with reference to the accompanying drawings in which:
The source may be mounted on the mass spectrometer by way of mounting points (21 and 23) and corresponding mounting cavities (not shown) upon the source at a mounting plate (25). The mounting plate is hingably attached to the main source body by a plurality of hinges (27 and 29). A seal (31) seals the ion source to the mass spectrometer so that the source enclosure (33) is sealed in an air tight manner. The figure also shows outlet port (35) from which air is pumped from the mass spectrometer into the cavity (37) of the ion source (1). Heat sink (39) is arranged within the air path to cool the air passing through.
Table 1 and
As can be seen from the table and the graph in
Other Embodiments
It will be apparent that various modifications may be made to the particular embodiments discussed above without departing from the scope of the invention.
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| Number | Date | Country | |
|---|---|---|---|
| 20100301200 A1 | Dec 2010 | US |
