Claims
- 1. An antibody-PE40 recombinant fusion protein wherein said antibody is a single-chain Fv fragment (scFv) and said PE40 is a Pseudomonas exotoxin (PE) fragment omitting amino acids 1 through 252 possessing at least the translocating and ADP ribosylating activity of PE.
- 2. The fusion protein of claim 1, wherein said fusion protein has a single polypeptide chain.
- 3. The fusion protein of claim 2 wherein the antibody is anti-Tac(Fv).
- 4. A composition comprising an effective amount of the fusion protein of claim 1 to kill cells bearing a receptor or an antigen to which the antibody binds, and a pharmaceutically acceptable carrier.
- 5. The composition of claim 4, wherein the antibody is anti-Tac(Fv).
Parent Case Info
This is a divisional of U.S. Ser. No. 07/865,722, filed Apr. 8, 1992, which is a continuation of U.S. Ser. No. 07/341,361, filed on Apr. 21, 1989, now abandoned, which is a continuation-in-part of U.S. Ser. No. 06/911,227, filed on Sep. 24, 1986, U.S. Pat. No. 4,892,827.
US Referenced Citations (5)
Non-Patent Literature Citations (8)
Entry |
Kelley et al., 85 Proc. Nat'l. Acad. Sci. USA 3980-2984 (1988). |
Williams, G. 1988 Tibtech. 6, 36-42. |
Chaudhary et al., 1989 Nature 339, 394-397. |
Vitteto et al., 197 Science 238, 1098-1104. |
Chaudhary et al., 1988 Proc. Nat'l. Acad. Sci. USA 85, 2939-2943. |
Hwang et al., 1987 Cell 48, 129-136. |
Seigall et al., 1988 Proc. Nat'l Acad. Sci. USA 85, 9738-9742. |
Lorderbaum-Galski et al., 1988 Proc. Nat'l Acad. Sci. USA 85, 1922-1926. |
Divisions (1)
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Number |
Date |
Country |
Parent |
865722 |
Apr 1992 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
341361 |
Apr 1989 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
911227 |
Sep 1986 |
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