Patent Application
20240201110
The present disclosure relates to the field of a cabinet X-ray incorporating a system and method for taking an X-ray image utilizing a photon counting detector.
Today, conventional breast specimen systems can gather a digital breast specimen radiogram and display it in grayscale. In these systems, the radiograms of a tissue or bone specimen are only shown in a grayscale with white distinguishing a very dense item, black distinguishing a non-dense item and various shades of gray distinguishing density level between very dense item and non-dense item, the darker the gray color, the more dense the item.
With a unit incorporating a system and method of utilizing photon counting, the clinician can utilize the resultant image to expeditiously visualize the multitude of densities of the specimen excised from the patient to confirm orientation of the excised sample saving time for both the patient on the treatment table and the clinician.
It would be advantageous in breast procedure rooms to allow the medical professional to operate the cabinet X-ray unit to analyze the excised breast tissue or specimen utilizing the unit to capture an X-ray image captured by a photon counting detector and maybe taken at different energies or techniques of the sample for informational and/or diagnostic purposes. As a result of processing of the multiple projections, a clinician or physician could view the images in the same and exact orientation with different colors denoting a density and construction of the excised tissue.
A major advantage of color or gray scale resolving X-ray Imaging, compared to regular X-ray imaging systems, is the capability to discriminate energy of detected X-rays. This opens the possibility to even recognize different materials in X-ray images. Photons which are in the x-ray spectrum images are measured at different energy discrimination thresholds. The images are then analyzed using software tools and a color or gray scale image is created. Colors or gray scale levels in the image represent different elements in the sample that are of different densities.
The image may then be saved in various formats (e.g., jpeg, .tiff, DICOM, etc.) and resolutions or views and then may be transferred in various resolutions or views in DICOM or any other transmittable format for review.
Specimen radiography is considered the most cost-effective screening method for the detection of breast cancer in surgically removed breast tissue. However, the sensitivity of specimen radiography is often limited by the presence of overlapping dense fibroglandular tissue in the breast specimen. Dense parenchyma reduces the conspicuity of abnormalities and thus constitutes one of the main causes of missed breast cancer diagnosis. The advent of full-field digital detectors offers opportunities to develop advanced techniques for improved imaging of dense breasts.
The present disclosure relates to the field of a cabinet X-ray incorporating an X-ray tube and a photon counting detector for the production of organic and non-organic specimen images. The computing device receives video data from the photon detector and determines the orientation and density composition of the specimen based on the captured photon data. This facilitates and aids the surgeon/user in ensuring that the proper amount of tissue has been excised. In particular, the disclosure relates to a system and method with corresponding apparatus for capturing an X-ray image utilizing a photon counting detector allowing a cabinet X-ray unit to attain and optimize images with the colorization radiograph for easier distinction.
The above radiographic images may be colorized to designate differing densities. In one embodiment, the aspects of the present disclosure are directed to a system and method including a cabinet X-ray system incorporating a photon counting detector. This embodiment includes a cabinet X-ray system, a base unit including an image processor and a display, an imaging chain incorporated into the base unit, including an X-ray source with photon-counting detector, a system configured to receive photon data and an interface for enabling an analog/digital signal to be transferred from an image capture apparatus to the image processor of the base unit. The system may be further be configured to supply standard or high-definition (HD) real-time images. A camera can be used to receive video data and may be digital to provide electronic images. The cabinet X-ray system may concurrently capture an X-ray image, photon-counting image, and a real-time image. The camera may be mounted onto the system so as to integrate an exact capture/orientation image of the sample being X-rayed. The unit may be enclosed in a cabinet X-ray system. The unit may be utilized for excised tissue, organ or bone specimens. The unit may be utilized for any organic or inorganic specimen that fits inside the system framework or X-ray cabinet. The image capturing mechanism may be mounted in a cabinet X-ray system, such as the cabinet system illustrated in the embodiment shown in
In this variation of the above-named embodiments, a photon counting detector is utilized within the same confines of the cabinet as is the multi-spectral x-ray source. Photon counting is a technique in which individual photons are counted using a single-photon detector (SPD). In contrast to a normal photodetector, which generates an analog signal proportional to the photon flux, a single-photon detector emits a pulse of signal every time a photon is detected. The total number of pulses (but not their amplitude) is counted, giving an integer number of photons detected per measurement period. The counting efficiency is determined by the quantum efficiency and any electronic losses that are present in the system.
Many photodetectors can be configured to detect individual photons, each with relative advantages and disadvantages. Common types include photomultipliers, Geiger counters, single-photon avalanche diodes, superconducting nanowire single-photon detectors, transition edge sensors, and scintillation counters. Charge-coupled devices can also sometimes be used. While in appearance they may appear similar in technology and packaging, photon counting eliminates gain noise, where the proportionality constant between analog signal out and number of photons varies randomly. Thus, the excess noise factor of a photon-counting detector is unity, and the achievable signal-to-noise ratio for a fixed number of photons will usually be higher than if the same detector were operated without photon counting.
Photon counting can improve temporal resolution. In a conventional detector, multiple arriving photons generate overlapping impulse responses, limiting temporal resolution to approximately the fall time of the detector. However, if it is known that a single photon was detected, the center of the impulse response can be evaluated to precisely determine the arrival time of the photon.
The method includes controlling the x-ray photon counting detector to collect an x-ray image of the specimen when the x-ray source is energized; determining the counts of detected photons of different areas of the specimen from data collected from the x-ray detector of the projection x-ray image of the specimen when the x-ray source is energized; creating a pixelated x-ray image of the specimen wherein the multiple pixelated areas and their photon counts of the specimen are indicated as a density or range of densities based on the determined density of different areas of the specimen; and selectively displaying the density x-ray image of the specimen on the display in a plethora of pre-determined colors for the operator to observe
The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
To further clarify the above and other advantages and features of the present disclosure, a more particular description of the disclosure will be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings. It is appreciated that these drawings depict only typical embodiments of the disclosure and are therefore not to be considered limiting of its scope. The disclosure will be described and explained with additional specificity and detail through the use of the accompanying drawings in which:
In general, aspects of this disclosure include a device (cabinet X-ray system) utilizing an optical camera to capture an optical image (in black and white, gray scale or color, preferably color), preferably in real-time, of a sample or specimen which is also being X-rayed utilizing a multi-spectral source to produce an X-ray image either pixelated utilizing photon-counting, in grayscale via a standard x-ray detector indicating the density of different areas of the sample or specimen, via photon-counting or density detection via ADU preferably with the resulting 2 images being at substantially or, preferably exactly, the same orientation. The X-ray image can include a two-dimensional (2-D) X-ray image or a synthetic X-ray image assembled from more than one X-ray image (e.g., a tomosynthetic image). The above captured image is then colorized to display the differing densities via ADU or photon counting.
Gain on a camera represents the conversion factor from electrons (e−) into digital counts, or Analog-Digital Units (ADUs). Gain is expressed as the number of electrons that get converted into a digital number, or electrons per ADU (e−/ADU).
The photo/captured camera optical image, preferably in real-time, may be displayed on the monitor either overlaid/blended/combination image onto the resultant density colorized or gray scale density X-ray image or synthetic X-ray image assembled from more than one X-ray image (e.g., a tomosynthetic image) of the sample or as back to back viewing on a monitor between at least any two of these images or a side-by-side or Picture-In-a-Picture (PIP) including displayed adjacent to the X-ray image or synthetic X-ray image of the sample. A device capturing both an X-ray image and an optical image, the latter two preferably in real-time, of the specimen facilitates confirmation and orientation for the clinician to verify margins and other specimen features are achieved by the professional after it is removed from a patient.
A preferred embodiment system would be to incorporate an HD (high-definition) optical camera into a cabinet X-ray unit allowing the system to capture an HD optical image and X-ray image either pixelated utilizing a standard x-ray detector or a photon counting detector to display the captured images, in grayscale or colorized of the specimen where the images so obtained can be displayed as disclosed herein.
The present disclosure and embodiments included therein can relate to specimen radiography but the disclosure is not isolated to specimen radiography but may be utilized, for example, for non-destructive testing, pathology as well as any radiographic analysis of organic and non-organic samples or specimens, requiring a cabinet X-ray system but is not limited to just an HD camera but to any camera fitting within the confines of the cabinet X-ray system.
Various x-ray detector to obtain radiographs are utilized to capture x-rays. Common types for standard x-ray radiography are charge integrating devices such as Complementary metal-oxide-semiconductor (CMOS), direct or indirect detection flat panels (Scintillator screen, Amorphous Silicon (a-Si), Amorphous Selenium (a-Se), Charge-coupled devices (CCD).
Common types for photon counting x-ray detectors include photomultipliers, Geiger counter, single-photon avalanche diodes, superconducting nanowire single-photon detectors, transition edge sensors, and scintillation counters. Charge-coupled devices can also sometimes be used. Also, hybrid photon counting technology which uses CMOS or other ASIC technologies.
Reference will now be made to figures wherein like structures will be provided with like reference designations. It is understood that the drawings are diagrammatic and schematic representations of exemplary embodiments of the disclosure and are not limiting of the present disclosure nor are they necessarily drawn to scale.
The systems and methods of embodiments of the present disclosure also address unmet needs by providing 2-D X-ray imaging and tomosynthesis apparatus and techniques that include optical imaging for imaging breast specimens that overcome the shortfall of the data received from two-dimensional and tomosynthesis imaging systems alone. The aspects of embodiments of the present disclosure also enable the use of tomosynthesis to efficiently provide accurate three-dimensional imaging of a specimen in which overlapping images having differing attenuation characteristics can be obtained by applying a three-dimensional reconstruction algorithm all in an X-ray cabinet system.
As used herein, the term “computer,” “computer system”, or “processor” refers to any suitable device operable to accept input, process the input according to predefined rules, and produce output, including, for example, a server, workstation, personal computer, network computer, wireless telephone, personal digital assistant, one or more microprocessors within these or other devices, or any other suitable processing device with accessible memory.
The term “computer program” or “software” refers to any non-transitory machine-readable instructions, program or library of routines capable of executing on a computer or computer system including computer readable program code.
Digital breast specimen tomosynthesis is disclosed in U.S. Patent Publication No. 208/0131773 (granted as U.S. Pat. No. 9,138,193), Lowe, et al., entitled “SPECIMEN RADIOGRAPHY WITH TOMOSYNTHESIS IN A CABINET,” the disclosure of which is hereby incorporated by reference in its entirety.
The overlaying of the radiograph and related disclosure; U.S. Patent Publication No. 2019/0117073, entitled “SYSTEM AND METHOD FOR ATTAINING, SAVING, AND TRANSFERRING A COMBINATION/BLENDED IMAGE FROM CABINET X-RAY SYSTEMS,” the disclosure of which is hereby incorporated by reference in its entirety.
The terms “camera” or “optical camera” refer to an instrument, including an optical instrument for capturing images in black and white, gray scale or color (preferably color) using reflected and/or emitted wavelengths of the electromagnetic spectrum, for example, visible light or fluorescent light, from an object, similar to a photograph or that which could be viewed by a human eye, using an electronic light-sensitive sensor array. These terms may include such instruments producing images in standard resolution or HD as well as a digital camera that can directly capture and store an image in computer-readable form using an array of electronic light-sensitive elements—typically semiconductor photo-sensors—that produce a light-intensity-dependent electronic signal in response to being illuminated.
Reference will now be made to figures wherein like structures will be provided with like reference designations. It is understood that the drawings are diagrammatic and schematic representations of exemplary embodiments of the disclosure and are not limiting of the present disclosure nor are they necessarily drawn to scale.
Specimen tomography is a three-dimensional specimen imaging system. It involves acquiring images of a sample at multiple viewpoints, typically over an arc or linear path. The three-dimensional image is constructed by the reconstruction of the multiple image data set.
In one embodiment, the detector 20, X-ray source 10, and the swing arm 60 servo mechanism are controlled via a combination of one or more of software and hardware, such as non-transitory machine-readable instructions stored in a memory that are executable by one or more processors. On example of such a configuration can include controller cards of a computer 470 (
For example, if we bin at a 2×2 ratio, then there would be an effective spatial resolution of approximately 149.6 micrometers. This binning may be achieved within the original programming of the detector 20 or within the computer 470 providing the tomosynthetic compilation and image.
Between the outer wall 421 of cabinet 422 and the sample chamber 444 are sheets of lead 452 that serve as shielding to reduce radiation leakage emitted from the X-ray source 10. In the example of
In one embodiment, a controller or computer 470 controls the collection of data from the detector 20, controls the swing arm 60 and X-ray source 10. A monitor 472 displays the compiled data and can, for example, be mounted on an articulating arm 474 that is attached to the cabinet 422. The computer 470 receives commands and other input information entered by the operator via a user interface 476, such as a keyboard and mouse for example. In one embodiment, the computer 470 can comprise a touch screen or near touch screen device. Although the aspects of the disclosed embodiments will generally be described with respect to a computer 470, it will be understood that the computer 470 can comprise any suitable controller or computing device. Such computing devices can include, but are not limited to, laptop computers, minicomputers, tablets and pad devices.
The computer 470 can be configured to communicate with the components of the X-ray cabinet system 400 in any suitable manner, including hardwired and wireless communication. In one embodiment, the computer 470 can be configured to communicate over a network, such as a Local Area Network or the Internet.
The aspects of the disclosed embodiments are generally directed to a system that can utilize an optical camera, preferably a real-time camera, to capture a visual image of a specimen/sample concurrently or at substantially the same time as the acquisition of an X-ray image. Referring to
In the systems and methods included in this disclosure as well as the embodiments disclosed herein, the resulting X-ray generated and optical camera images can be displayed each alone or together as overlaid/blended together, adjacent or PIP (Picture-in-Picture) on the monitor—472 of
For exemplary descriptive purposes, in a normal X-ray or tomosynthetic image (i.e., before the densities of the different area of the specimen are determined and an image produced therefrom), there can be five different densities that can be useful to determine the nature of an abnormality (e.g., air, fat, soft tissue, bone and metal). If there is an unexpected increase or decrease in the density of a known anatomical structure then this may help determine the tissue structure of the abnormality. Low density material such as air is represented as black on the normal X-ray or radiograph image. Very dense material such as metal or contrast material is represented as white. Bodily tissues are varying degrees of gray, depending on density, and thickness. Utilizing artificial intelligence and neural networks, the algorithm of embodiments of the present disclosure can take the varying degrees of gray of a normal X-ray image and interpolates them in a color palate or gray scale where the different colors or shades of gray indicate different densities or a range of densities of areas of the specimen. Changes in color can be more easily perceived than changes in shades of gray of the initial X-ray image and therefore this procedure makes the interpretation and understanding of the image easier for a medical professional (e.g., surgeon or other medical doctor). During colorization, for example, the algorithm replaces a scalar value representing pixel's intensity with a vector in a given color space. Since the mapping between intensity and color has no inherently correct solution, human interaction and external information usually plays a large role in evaluating the original X-ray image.
One embodiment of the present disclosure utilizes a controller or computer of embodiments of the present disclosure, for example a controller or computer 470 in
Separate image layers for each material, for example, one layer containing only bone, one containing only fat, etc. of the original X-ray image can be assigned a color (or color range) or gray scale level for each material of the specimen. Any color can be chosen, but in one embodiment, colors can be chosen that look similar to what one would expect to see in the specimen itself. Once the colors (or color range) or gray scale for the different densities or range of densities are chosen, the different colors (or color range) or gray scale for those areas of the specimen are combined to produce a single color or gray scale image. Such images can also be adjusted to edit out one or more specific density amounts or range of density amounts, thus, only showing in an image, those densities or range of densities that a medical professional (e.g., surgeon or other medical doctor) desires to examine and have in the image.
Cabinet X-ray systems or units of the present disclosure can operate by analyzing the ADU (analog-to-digital) units that are the formation of all photographs whether they be radiographs or photographs. Such embodiments can minutely compare the differences between neighboring pixels in terms of magnitude and succinctly assigns a color, shade of color or gray scale level to each density or range of densities after assigning a color or gray scale for full black and one for full white.
A radiographic image is composed of a ‘map’ of X-rays that have either passed freely through the specimen or have been variably attenuated (absorbed or scattered) by anatomical structures. The denser the tissue, the more X-rays are attenuated. For example, X-rays are attenuated more by bone than by lung tissue. Contrast within the overall image depends on differences in both the density of structures in the body and the thickness of those structures. The greater the difference in either density or thickness of two adjacent structures leads to greater contrast between those structures within the image.
Another embodiment of the cabinet X-ray systems or units of the present disclosure can distinguish different material of the specimen by training or including an algorithm to analyze the system imaging the specimen using the same technique, kVp and mA (the mA (tube current and exposure time product) and filtration, kVp (tube voltage), two settings that can be adjusted on X-ray system to control the image quality and patient dose. The algorithm would need to be calibrated and it would record the ADU unit for each density/material in the specimen and utilizing a table or other list in memory of information on the densities of different material, discern the different materials making up the specimen.
Another embodiment of the present disclosure can use the difference in X-ray magnitude from each pixel that indicates the density of area of the specimen in a 2-D X-ray and then using that difference (e.g., either from the difference data directly or from 2-D density X-ray images formed using that data) from multiple such 2-D X-ray images of the same specimen area to generate a colorized tomosynthetic image denoting density in that tomosynthetic image.
The detailed images of the embodiments of the present disclosure can be viewed in real-time and/or saved for future examination in various formats in the main computer 470 and then may be transmitted via USB, ethernet, Wi-Fi, etc. in various formats that may include DICOM, .tiff. or .jpeg, non-inclusive.
One embodiment of the cabinet X-ray system or unit of the present disclosure includes a controller or computer, for example a controller or computer 470 in
Display or monitor 472 is for conveniently viewing both images of embodiments of the present disclosure and the output of the processing unit 102 thereon. Display or monitor 472 may also include a user interface as user interface 476 exemplified in the embodiment of
Embodiments of the present disclosure can be illustrated in
In the embodiment utilizing photon-counting,
In the next series of images
Indeed, it is appreciated that the system and its individual components can include additional features and components, though not disclosed herein, while still preserving the principles of the present disclosure. Note also that the base computer can be one of any number devices, including a desktop or laptop computer, etc.
Aspects of the present disclosure may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative, not restrictive. All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope.
This written description uses examples as part of the disclosure, including the best mode, and also to enable any person skilled in the art to practice the disclosed implementations, including making and using any devices or systems and performing any incorporated methods. The patentable scope is defined by the claims, and may include other examples that occur to those skilled in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal languages of the claims.
While there have been shown, described and pointed out, fundamental features of the present disclosure as applied to the exemplary embodiments thereof, it will be understood that various omissions and substitutions and changes in the form and details of compositions, devices and methods illustrated, and in their operation, may be made by those skilled in the art without departing from the spirit or scope of the present disclosure. Moreover, it is expressly intended that all combinations of those elements and/or method steps, which perform substantially the same function in substantially the same way to achieve the same results, are within the scope of the present disclosure. Moreover, it should be recognized that structures and/or elements and/or method steps shown and/or described in connection with any disclosed form or embodiment of the present disclosure may be incorporated in any other disclosed or described or suggested form or embodiment as a general matter of design choice. It is the intention, therefore, to be limited only as indicated by the scope of the claims appended hereto.
| Number | Date | Country | |
|---|---|---|---|
| 63431362 | Dec 2022 | US |
