Unspecific monooxygenase (1.14.14.1)

Industry

CPC
C12Y114/14001

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Parent Industries

CCHEMISTRY METALLURGY C12Biochemistry C12YENZYMES C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)

Current Industry

C12Y114/14001Unspecific monooxygenase (1.14.14.1)

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Production of symmetrical bolaform sophorosides
- Patent number 12,110,527
- Issue date Oct 8, 2024
- Universiteit Gent
- Sophie Roelants
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protecting group chemistry for clean, reductant-free dyeing
- Patent number 12,098,405
- Issue date Sep 24, 2024
- The Regents of the University of California
- John Eugene Dueber
- C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information Patent Grant
Methods of producing omega-hydroxylated fatty acid derivatives
- Patent number 11,981,952
- Issue date May 14, 2024
- Genomatica, Inc.
- Andreas W. Schirmer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organelle-targeted genetically-encoded voltage indicators and metho...
- Patent number 11,846,628
- Issue date Dec 19, 2023
- Wisconsin Alumni Research Foundation
- Meyer Jackson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 11,807,874
- Issue date Nov 7, 2023
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Eplerenone for phenotyping of CYP3A5 enzyme activity in saliva samples
- Patent number 11,747,352
- Issue date Sep 5, 2023
- Concordia University, Inc.
- Joseph McGraw
- G01 - MEASURING TESTING
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 11,591,578
- Issue date Feb 28, 2023
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Artificial metalloenzymes containing noble metal-porphyrins
- Patent number 11,518,768
- Issue date Dec 6, 2022
- The Regents of the University of California
- John F. Hartwig
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Monooxygenase and use in preparation of optically pure sulfoxide
- Patent number 11,345,900
- Issue date May 31, 2022
- Jiangsu AoSaiKang Pharmaceutical Co., Ltd.
- Yan Zhang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 11,279,917
- Issue date Mar 22, 2022
- Codexis, Inc.
- Robert Osborne
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Fatty acid decarboxylase and its uses
- Patent number 11,236,367
- Issue date Feb 1, 2022
- Commissariat a l'Energie Atomique et Aux Energies Alternatives
- Frederic Beisson
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Alkane oxidation by modified hydroxylases
- Patent number 11,214,817
- Issue date Jan 4, 2022
- California Institute of Technology
- Frances Arnold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protecting group chemistry for clean, reductant-free dyeing
- Patent number 11,203,774
- Issue date Dec 21, 2021
- The Regents of the University of California
- John Eugene Dueber
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Mutant enzymes
- Patent number 11,155,790
- Issue date Oct 26, 2021
- OXFORD UNIVERSITY INNOVATION LIMITED
- Luet Lok Wong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for producing fragrant alcohols
- Patent number 11,130,972
- Issue date Sep 28, 2021
- Firmenich SA
- Laurent Daviet
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Highly active self-sufficient nitration biocatalysts
- Patent number 11,078,467
- Issue date Aug 3, 2021
- University of Florida Research Foundation, Incorporated
- Yousong Ding
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Mutant 4-hydroxyphenylacetate 3-hydroxylases and uses thereof
- Patent number 10,988,786
- Issue date Apr 27, 2021
- Symrise AG
- Ludger A. Wessjohann
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 10,982,197
- Issue date Apr 20, 2021
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for producing an organosilicon product
- Patent number 10,927,355
- Issue date Feb 23, 2021
- California Institute of Technology
- Sek Bik Jennifer Kan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-F...
- Patent number 10,717,991
- Issue date Jul 21, 2020
- Chong Kun Dang Pharmaceutical Corp.
- Byeong Chun Lee
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Methods of producing omega-hydroxylated fatty acid derivatives
- Patent number 10,711,288
- Issue date Jul 14, 2020
- Genomatica, Inc.
- Andreas W. Schirmer
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 10,704,030
- Issue date Jul 7, 2020
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protecting group chemistry for clean, reductant-free dyeing
- Patent number 10,704,070
- Issue date Jul 7, 2020
- The Regents of the University of California
- John Eugene Dueber
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 10,689,627
- Issue date Jun 23, 2020
- Codexis, Inc.
- Robert Osborne
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Alkane oxidation by modified hydroxylases
- Patent number 10,648,006
- Issue date May 12, 2020
- California Institute of Technology
- Frances Arnold
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Method for producing fragrant alcohols
- Patent number 10,570,420
- Issue date Feb 25, 2020
- Firmenich SA
- Laurent Daviet
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Prodrugs of dithiol mucolytic agents
- Patent number 10,526,283
- Issue date Jan 7, 2020
- Parion Sciences, Inc.
- Michael Ross Johnson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Mutant enzymes
- Patent number 10,501,727
- Issue date Dec 10, 2019
- Isis Innovation Limited
- Luet Lok Wong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and systems for sulfimidation or sulfoximidation of organic...
- Patent number 10,501,762
- Issue date Dec 10, 2019
- California Institute of Technology
- Christopher C. Farwell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
P450-BM3 variants with improved activity
- Patent number 10,450,550
- Issue date Oct 22, 2019
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
PRODUCTION OF D-LYSERGIC ACID
- Publication number 20250027092
- Publication date Jan 23, 2025
- National University of Singapore
- Wei Jie Garrett WONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods Of Producing Omega-Hydroxylated Fatty Acid Derivatives
- Publication number 20250019731
- Publication date Jan 16, 2025
- Genomatica, Inc.
- Andreas W. Schirmer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
OPTIMIZED CYP4V2 GENE AND APPLICATION THEREOF
- Publication number 20240366794
- Publication date Nov 7, 2024
- SUZHOU NGGT BIOTECHNOLOGY CO.,LTD.
- Qing CAO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Variant Cytochrome P450 Monooxygenases and Uses Thereof
- Publication number 20240352431
- Publication date Oct 24, 2024
- BluumBio Inc.
- Katherine French
- C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
Information Patent Application
Compositions, Systems and Methods for Atom Transfer Radical Additio...
- Publication number 20240336943
- Publication date Oct 10, 2024
- The Regents of the University of California
- Yang Yang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BIOSYNTHETIC PRODUCTION OF DELTA-LACTONES USING CYTOCHROME P450 HYD...
- Publication number 20240318210
- Publication date Sep 26, 2024
- Conagen Inc.
- Haiyun Pan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
- Publication number 20240318152
- Publication date Sep 26, 2024
- Codexis, Inc.
- David Entwistle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CYTOCHROME P450 ENZYME
- Publication number 20240263208
- Publication date Aug 8, 2024
- HYPHA DISCOVERY LTD.
- Jonathan STEELE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Tropane Alkaloid Transporters and Methods of Making Tropane Alkaloi...
- Publication number 20240191267
- Publication date Jun 13, 2024
- The Board of Trustees of the Leland Stanford Junior University
- Christina D. Smolke
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BIOSYNTHESIS OF MOGROSIDES
- Publication number 20240158451
- Publication date May 16, 2024
- Ginkgo Gioworks, Inc.
- Diveena Becker
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF
- Publication number 20240084272
- Publication date Mar 14, 2024
- The University of British Columbia
- Thu-Thuy T. Dang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HEPATOCELLULAR CARCINOMA TREATMENTS, PROPHYLACTIC THERAPIES, AND CO...
- Publication number 20240075108
- Publication date Mar 7, 2024
- Repair Biotechnologies, Inc.
- Mourad Topors
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Cytochrome P450 Mutant Protein and Use Thereof
- Publication number 20240035062
- Publication date Feb 1, 2024
- GsynBioT (Shanghai) Co., Ltd.
- Zhihua Zhou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
- Publication number 20240026313
- Publication date Jan 25, 2024
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENZYMATIC METHODS FOR CONVERTING LCA AND 3-KCA TO UDCA AND 3-KUDCA
- Publication number 20230416800
- Publication date Dec 28, 2023
- Sandhill One, LLC
- J. GREGORY REID
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
A PROPOFOL SENSOR
- Publication number 20230293063
- Publication date Sep 21, 2023
- SOMNUS SCIENTIFIC LTD
- David FERRIER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
- Publication number 20230250403
- Publication date Aug 10, 2023
- Codexis, Inc.
- Robert Osborne
- H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
Information Patent Application
ORGANELLE-TARGETED GENETICALLY-ENCODED VOLTAGE INDICATORS AND METHO...
- Publication number 20230228737
- Publication date Jul 20, 2023
- Wisconsin Alumni Research Foundation
- Meyer Jackson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
P450 BM3 MONOOXYGENASE VARIANTS FOR C19-HYDROXYLATION OF STEROIDS
- Publication number 20230212532
- Publication date Jul 6, 2023
- Bayer Aktiengesellschaft
- Oliver KENSCH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BIOCATALYTIC TECHNIQUES
- Publication number 20230040326
- Publication date Feb 9, 2023
- HYPHA DISCOVERY LIMITED
- Jonathan Charles Paul STEELE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
- Publication number 20220169994
- Publication date Jun 2, 2022
- Codexis, Inc.
- Robert Osborne
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING
- Publication number 20220136024
- Publication date May 5, 2022
- The Regents of the University of California
- John Eugene DUEBER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ALKANE OXIDATION BY MODIFIED HYDROXYLASES
- Publication number 20220112524
- Publication date Apr 14, 2022
- THE CALIFORNIA INSTITUTE OF TECHNOLOGY
- Frances Arnold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DEVICE FOR DETECTING ORGANOPHOSPHATES
- Publication number 20220062906
- Publication date Mar 3, 2022
- Plantvax, Inc.
- Yvonne J. Rosenberg
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
METHOD FOR PRODUCING FRAGRANT ALCOHOLS
- Publication number 20220056485
- Publication date Feb 24, 2022
- FIRMENICH SA
- Laurent Daviet
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMPROVED PRODUCTION OF SYMMETRICAL BOLAFORM SOPHOROSIDES
- Publication number 20220033869
- Publication date Feb 3, 2022
- Universiteit Gent
- Sophie Roelants
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MONOXYGENASE AND USE IN PREPARATION OF OPTICALLY PURE SULFOXIDE
- Publication number 20220002684
- Publication date Jan 6, 2022
- East China University of Science and Technology
- Yan ZHANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
- Publication number 20210214694
- Publication date Jul 15, 2021
- Codexis, Inc.
- Robert Osborne
- H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
Information Patent Application
METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES
- Publication number 20210071212
- Publication date Mar 11, 2021
- Genomatica, Inc.
- Andreas W. Schirmer
- Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMA...
Information Patent Application
ALKANE OXIDATION BY MODIFIED HYDROXYLASES
- Publication number 20200399662
- Publication date Dec 24, 2020
- THE CALIFORNIA INSTITUTE OF TECHNOLOGY
- Frances Arnold
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Unspecific monooxygenase (1.14.14.1)

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Production of symmetrical bolaform sophorosides

Protecting group chemistry for clean, reductant-free dyeing

Methods of producing omega-hydroxylated fatty acid derivatives

Organelle-targeted genetically-encoded voltage indicators and metho...

P450-BM3 variants with improved activity

Eplerenone for phenotyping of CYP3A5 enzyme activity in saliva samples

P450-BM3 variants with improved activity

Artificial metalloenzymes containing noble metal-porphyrins

Monooxygenase and use in preparation of optically pure sulfoxide

P450-BM3 variants with improved activity

Fatty acid decarboxylase and its uses

Alkane oxidation by modified hydroxylases

Protecting group chemistry for clean, reductant-free dyeing

Mutant enzymes

Method for producing fragrant alcohols

Highly active self-sufficient nitration biocatalysts

Mutant 4-hydroxyphenylacetate 3-hydroxylases and uses thereof

P450-BM3 variants with improved activity

Method for producing an organosilicon product

Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-F...

Methods of producing omega-hydroxylated fatty acid derivatives

P450-BM3 variants with improved activity

Protecting group chemistry for clean, reductant-free dyeing

P450-BM3 variants with improved activity

Alkane oxidation by modified hydroxylases

Method for producing fragrant alcohols

Prodrugs of dithiol mucolytic agents

Mutant enzymes

Methods and systems for sulfimidation or sulfoximidation of organic...

P450-BM3 variants with improved activity

Patents Applicationslast 30 patents

PRODUCTION OF D-LYSERGIC ACID

Methods Of Producing Omega-Hydroxylated Fatty Acid Derivatives

OPTIMIZED CYP4V2 GENE AND APPLICATION THEREOF

Variant Cytochrome P450 Monooxygenases and Uses Thereof

Compositions, Systems and Methods for Atom Transfer Radical Additio...

BIOSYNTHETIC PRODUCTION OF DELTA-LACTONES USING CYTOCHROME P450 HYD...

P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

CYTOCHROME P450 ENZYME

Tropane Alkaloid Transporters and Methods of Making Tropane Alkaloi...

BIOSYNTHESIS OF MOGROSIDES

CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF

HEPATOCELLULAR CARCINOMA TREATMENTS, PROPHYLACTIC THERAPIES, AND CO...

Cytochrome P450 Mutant Protein and Use Thereof

NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

ENZYMATIC METHODS FOR CONVERTING LCA AND 3-KCA TO UDCA AND 3-KUDCA

A PROPOFOL SENSOR

NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

ORGANELLE-TARGETED GENETICALLY-ENCODED VOLTAGE INDICATORS AND METHO...

P450 BM3 MONOOXYGENASE VARIANTS FOR C19-HYDROXYLATION OF STEROIDS

BIOCATALYTIC TECHNIQUES

NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

PROTECTING GROUP CHEMISTRY FOR CLEAN, REDUCTANT-FREE DYEING

ALKANE OXIDATION BY MODIFIED HYDROXYLASES

DEVICE FOR DETECTING ORGANOPHOSPHATES

METHOD FOR PRODUCING FRAGRANT ALCOHOLS

IMPROVED PRODUCTION OF SYMMETRICAL BOLAFORM SOPHOROSIDES

MONOXYGENASE AND USE IN PREPARATION OF OPTICALLY PURE SULFOXIDE

NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES

ALKANE OXIDATION BY MODIFIED HYDROXYLASES