Claims
- 1. A method of identifying at least one polymer for binding with a receptor comprising the steps of:
a) on a substrate, said substrate comprising polymers immobilized on a surface of said substrate, said polymers comprising a photoremovable protective group, irradiating a first region of said substrate without irradiating a second region of said substrate to remove said protecting group from said polymers in said first region; and b) contacting said substrate with a first monomer to couple said monomer to said polymer in said first region, forming a first polymer on said substrate in said first region that is different from said polymer in said second region.
- 2. The method as recited in claim 1 wherein said step of irradiating is a step of masking a light source with a mask, said mask comprising first transparent regions and second opaque regions, said transparent regions transmitting light from said source to said first regions, and said opaque regions blocking light from said source to said second regions.
- 3. The method as recited in claim 1 wherein said first and second regions each have total areas less than about 1 cm2.
- 4. The method as recited in claim 1 wherein said steps of irradiating are conducted with a monochromatic light.
- 5. The method as recited in claim 1 wherein said step of irradiating a first region is a step of masking a light source with a mask located in a first position, and wherein said step of irradiating a second region is a step of masking a light source with said mask located in a second position.
- 6. The method as recited in claim 1 wherein the step of irradiating further comprises the steps of:
a) placing a mask adjacent to said substrate, said mask having substantially transparent regions and substantially opaque regions at a wavelength of light; and b) illuminating said mask with a light source, said light source producing at least said wavelength of light.
- 7. The method as recited in claim 1 wherein said steps of irradiating are repeated so as to synthesize 103 different polymers on said substrate.
RELATED APPLICATIONS
[0001] This application is a continuation in part of U.S. Ser. No. 492,462, filed Mar. 7, 1990 and U.S. Ser. No. 624,120, filed Dec. 6, 1990. It is also related to the following United States applications: U.S. Ser. No. 362,901, filed Jun. 7, 1989; U.S. Ser. No. 626,730, filed Dec. 6, 1990; U.S. Ser. No. 624,114, filed Dec. 6, 1990. Each of these applications is incorporated herein by reference for all purposes. This application is also related to application Ser. No. ______, ______, and ______ (attorney docket numbers 11509-39, 11509-46, and 11509-51), all filed on Nov. 22, 1991 and all incorporated herein by reference for all purposes. This application is also related to PCT application WO 90/15070 which was published Dec. 13, 1990 and is also incorporated by reference herein for all purposes.
Continuations (2)
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Number |
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Parent |
08348471 |
Nov 1994 |
US |
Child |
10014716 |
Dec 2001 |
US |
Parent |
07805727 |
Dec 1991 |
US |
Child |
08348471 |
Nov 1994 |
US |
Continuation in Parts (4)
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Parent |
07492462 |
Mar 1990 |
US |
Child |
07805727 |
Dec 1991 |
US |
Parent |
07362901 |
Jun 1989 |
US |
Child |
07492462 |
Mar 1990 |
US |
Parent |
07492462 |
Mar 1990 |
US |
Child |
07624120 |
Dec 1990 |
US |
Parent |
07362901 |
Jun 1989 |
US |
Child |
07624120 |
Dec 1990 |
US |