Detector for a bipolar time-of-flight mass spectrometer

Abstract

A replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity is disclosed. A mass detector is electro-optically isolated from a charge collector with an electron multiplier for converting a charged particle into a multiplicity of electrons and a scintillator for converting the multiplicity of electrons into a multiplicity of photons. A light sensor is provided to convert the multiplicity of photons back into electrons which are summed into a charge pulse. The light sensor is realized by any of a plurality of photo-responsive devices.

Description

BACKGROUND OF THE INVENTION

Conventional time-of-flight mass spectrometry (TOFMS) is a technique that uses electron impact (EI) ionization. EI ionization involves irradiating a gas phase molecule of the unknown composition with an electron beam, which displaces outer orbital electrons, thereby producing a net positive charge on the newly formed ion.

TOFMS has seen a resurgence due to the commercial development of two new ionization methods: electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). The availability of low cost pulsed extraction electronics, high speed digital oscilloscopes and ultra-high speed microchannel plate detectors have improved the mass resolution capability of the traditional TOFMS technique.

Mass spectrometers include three major components: (1) an ionization source; (2) a mass filter; and (3) a detector. The ionization source ionizes an unknown composition. The mass filter temporally separates the resultant ions so that lighter ions reach the detector before the heavier ions. The detector converts the ions into a charge pulse. The detector ascertains the arrival times of the charge pulses, which correspond to the masses of the ions. Identifying the masses of the ions enables identification of the unknown composition.

Typically, a TOF mass spectrometer also has a digitizer connected to the detector to process the signals.

In the MALDI technique, the analyte of interest is usually mixed in solution with a large excess of light absorbing matrix material. The sample mixture is placed on a mass spectrometer sample plate and illuminated with a pulse of light from a pulsed laser. The matrix material absorbs the laser light, the analyte molecules are desorbed from the sample surface and ionized by one of a number of ionization mechanisms.

In ESI, the analyte of interest is normally dissolved in an acidified solution. This solution is pumped out the end of a metallic capillary tube held at a high potential. This potential causes the evaporation of extremely small droplets that acquire a high positive charge. Through one of a number of mechanisms, these small droplets continue to evaporate until individual molecular ions are evaporated from the droplet surface into the gas phase. These ions then are extracted through a series of ion optics into the source region of the TOFMS.

The mass filter temporally separates ions by accelerating the ions with a bias voltage ranging up to ±30 M Since like charges repel, negative ions, for example, experience repulsive forces, thus tend to accelerate from, a negative potential toward a positive or less negative potential. A higher bias voltage will generate stronger repelling forces, thus greater ion acceleration. The repelling force accelerates lighter particles faster than heavier particles. Although smaller voltages foster better temporal separation, larger voltages allow for greater detection efficiency.

Detectors typically convert an ion into many electrons, forming an electron cloud which is more readily discernable. Three conventional types of detectors, or electron multipliers, generally have been used. The first type of electron multiplier is a single channel electron multiplier (SCEM). SCEM's typically are not used in modern TOFMS instruments because SCEM's provide limited dynamic range and temporal resolution, in the order of 20–30 nanoseconds to full width at half maximum (ns FWHM).

The second type of electron multiplier is a discrete dynode electron multiplier (DDEM). DDEMs exhibit good dynamic range, and are used in moderate and low resolution applications because of relatively poor pulse widths, in the order of 6–10 ns FWHM.

The third type of electron multiplier is a microchannel plate (MCP) electron multiplier. MCP's typically have limited dynamic range, in the order of 20 MHz/cm² of active area. However, MCP's provide the highest temporal resolution, in the order of 650 ps FWHM.

An ideal TOF electron multiplier should exhibit both high temporal resolution and high sensitivity to high-mass ions, as well as a disinclination to saturation.

As the present invention obtains both high temporal resolution and high sensitivity from an MCP-type electron multiplier, the following reviews the general operating characteristics of an MCP.

FIG. 1 shows an MCP 10. MCP 10 typically is constructed from a fused array of drawn glass tubes filled with a solid, acid-etchable core. Each tube is drawn according to conventional fiber-optic techniques to form single fibers called mono-fibers. A number of these mono-fibers then are stacked in a hexagonal array called a multi. The entire assembly is drawn again to form multi-fibers. The multi-fibers then are stacked to form a boule or billet which is fused together at high temperature. The fused billet is sliced on a wafer saw to the required bias angle, edged to size, then ground and polished to an optical finish, defining a glass wafer 15. Glass wafer 15 is chemically processed to remove the solid core material, leaving a honeycomb structure of millions of pores, also known as holes or channels, 20, which extend at an angle 25 relative to the normal flight trajectory of an ion between the surfaces 30 and 32 of MCP 10.

Referring also to FIG. 2, subsequent processing of the interior surface 35 of each channel 20 produces conductive and secondary electron emissive properties. These secondary electron emissive properties cause channel 20 to produce one or more electrons upon absorption or conversion of a particle, such as an ion, impacting surface 35. As a result, each channel 20 functions like an SCEM, having a continuous dynode source which operates relatively independently of surrounding channels 20.

Finally, a thin metal electrode 40, typically constructed from Inconel or Nichrome, is vacuum deposited on the surfaces 30 and 32 of wafer 15, electrically connecting all channels 20 in parallel. Electrodes 40 permit application of a voltage 45 across MCP 10.

MCP 10 receives ions 50 accelerated thereto by an ion-separating voltage. Ion 50 enters an input end 60 of channel 20 and strikes interior surface 35 at a point 62. The impact on surface 35 causes the emission of at least one secondary electron 65. Each secondary electron 65 is accelerated by the electrostatic field created by voltage 45 across channel 20 until electron 65 strikes another point (not shown) on interior surface 35. Assuming secondary electrons 65 have accumulated enough energy from the electrostatic field, each impact releases more secondary electrons 70. This process typically occurs ten to twenty times in channel 20, depending upon the design and use thereof, resulting in a significant signal gain or cascade of output electrons 80. For example, channel 20 may generate 50–500 electrons for each ion.

Gain impacts the sensitivity, or ability to detect an ion, of a spectrometer. A spectrometer with a high gain produces many electrons in an electron cloud corresponding to an ion, thus providing a larger target to detect.

To increase the gain of channel 20, or produce a greater amount of electrons for every ion strike, channel 20 must exhibit enhanced secondary emissivity qualities or conversion efficiency. Enhancing the secondary emissivity qualities of channel 20 is a standing goal.

The gain of channel 20 also is a function of the length-to-diameter ratio (l/d) thereof. This allows for considerable reduction in both length and diameter which permits the fabrication of very small arrays of channels 20 in MCP 10.

In conventional TOF mass spectrometers, electron clouds produced at the channel output are driven toward an anode or charge collector, such as a Faraday cup (not shown). The charge collector sums or integrates the electron charges into a charge pulse, which is analyzed by a digitizer. Because lighter ions accelerate faster than the heavier ions, the voltage pulses correspond to the masses of the respective ions. The aggregate of arrival times of the voltage pulses corresponds to the mass spectrum of the ions. The mass spectrum of the ions aids in discerning the composition of the unknown composition.

Detecting the masses of very massive ions requires a high “post acceleration” potential between the ionization source and the MCP. A high post acceleration potential permits sufficient high mass ion conversion efficiency to enable detection of massive ions. However, MCP's cannot withstand excessive voltages there across without risk of significant degradation. Accordingly, some MCP-based spectrometers “float” or electronically isolate the anode from the charge collector. To this end, the MCP's output voltage is dropped to ground through a voltage divider. Unfortunately, this creates great potential for arcing or short circuiting between the output and the anode, the energy from which could damage or destroy sensitive and expensive spectrometry equipment. Thus, attaining superior temporal range with an MCP-based spectrometer which also has superior dynamic capabilities, or high sensitivity, may come at significant, unpredictable cost.

Another problem with MCP-based detectors is that, over time, MCP's wear and require replacement. Some mass spectrometers are constructed in a manner that does not permit field replacement of the MCP. Thus, when an MCP requires replacement, the entire spectrometer has to be returned to the manufacturer for refurbishment. This is undesirable in terms of cost and out-of-service time for the instrument.

To overcome this inconvenience, U.S. Pat. No. 5,770,858 ('858 patent) provides a cartridge containing an MCP which may be installed and uninstalled in the field. However, the charge collector of the '858 cartridge is not electro-optically isolated from the high post acceleration potential of the MCP element therein, like the present cartridge.

Ideally, a TOF electron multiplier should be bipolar, or able to detect both negative and positive ions, which are common to chemical compositions. Thus, the TOF electron multiplier should accommodate positive and negative ion acceleration voltages.

What is needed is a replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity.

SUMMARY OF THE INVENTION

The invention overcomes the problems discussed above with a replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity.

The invention eliminates the potential for destruction of expensive spectrometry equipment from high-voltage power surges due to current source, vacuum or other failures by electro-optically isolating the charge collector from the high post-acceleration potential across the detector assembly.

The invention improves the uptime of a TOF mass spectrometry device by providing an easily replaceable, electro-optically isolated MCP cartridge.

The invention improves the sensitivity of an MCP-based spectroscope by providing a coating on the MCP that enhances the secondary electron emissivity characteristics of the MCP selected from magnesium oxide (MgO), tin oxide (SnO₂), quartz (SiO₂), barium fluoride (BaF₂), rubidium tin (Rb₃Sn), beryllium oxide (BeO), diamond and combinations thereof.

The invention electro-optically isolates the detector from a spectrometer with a method of detecting a particle including accelerating the particle with a voltage, converting the particle into a multiplicity of electrons and converting the multiplicity of electrons into a multiplicity of photons. The photons then are converted back into electrons and summed into a charge pulse.

The invention also electro-optically isolates the detector from a spectrometer with an arrangement including an electron multiplier, for converting a particle into a multiplicity of electrons, and a scintillator, for converting the multiplicity of electrons into a multiplicity of photons.

Other features and advantages of the invention will become apparent upon reference to the following description and drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention is described below in conjunction with the following drawings, throughout which similar reference characters denote corresponding features, wherein:

FIG. 1 is a perspective view, partially in section, of a microchannel plate;

FIG. 2 is a schematic view of a single channel of the microchannel plate of FIG. 1;

FIG. 3 is a side elevational view of a detector assembly configured according to principles of the invention assembled with a vacuum flange of a mass spectrometer and an interposed shield;

FIG. 4 is an environmental perspective view of the embodiment of FIG. 3, without the interposed shield;

FIG. 5 is a side elevational view in partial cross-section of the detector assembly of FIG. 3 as viewed along line V—V in FIG. 6;

FIGS. 6 and 7 respectively are front and rear elevational views of the detector assembly of FIG. 3;

FIG. 8 is a side elevational view in partial cross-section, of the detector cartridge of FIG. 5 as viewed along line VIII—VIII in FIG. 9;

FIG. 9 is a front elevational view of the detector cartridge of FIG. 8;

FIG. 10 is an exploded, axial cross-sectional view of the detector cartridge of FIG. 8;

FIG. 10A is a fragmentary schematic view of a channel input having a coating, in accordance with the invention; and

FIGS. 11 and 12 are schematic views of alternative voltages across a mass spectrometer incorporating the detector assembly of FIG. 3.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The invention is a replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity.

FIGS. 3 and 4 show a modular detector assembly 100 assembled with a modified vacuum flange 200 of a TOF spectrometer (not shown). FIG. 3 also shows a shield 103 interposed between detector assembly 100 and flange 200. An ionization source (not shown) directs charged or neutral particles, for example, electrons, ions and photons, toward an input end 105 of detector assembly 100.

Detector assembly 100 is adapted to be secured to a vacuum side 210 of vacuum flange 200 with a plurality of rods 215.

A plurality of connectors 300 pass through flange 200. Connectors 300 supply electrical energy to pogo pins (not shown) which contact elements (not shown) for creating electric fields in detector assembly 100 for accelerating particles therein, as discussed below.

Shield 103 is connected to detector assembly 100 with threaded fasteners 107. Shield 103 shields connectors 300 from electromagnetic interference from particles directed toward detector assembly 100 during operation of the spectrometer.

Referring to FIGS. 5–7, detector assembly 100 includes a detector cartridge 700, a scintillator 800 and a charge collector 900. Detector cartridge 700 receives the ions which enter input end 105 from an ionization source (not shown) and produces electrons at intervals that correspond to the respective masses of the ions, as described above. Scintillator 800 receives output electrons from detector cartridge 700 and produces approximately 400 output photons for every electron absorbed. Collector 900 receives and converts the output photons into up to 10×10⁶ electrons and sums the electrons into a charge pulse. As discussed above, the timing of the pulses correspond to the masses of the ions, thereby aiding identification of an unknown composition.

Detector assembly 100 includes a base 110, a cap 115 and a collector mounting plate 120 which cooperate to receive and support detector cartridge 700, scintillator 800 and collector 900 in a spaced relationship therewith.

Base 110 has a stepped and tapered central opening 112 for receiving cartridge 700. Base 110 has a second stepped and tapered central opening 125 for receiving collector 900. Collector-mounting plate 120 has threads 122 which threadingly engage corresponding threads 124 of cap 115, which facilitates assembling cartridge 700, scintillator 800 and collector 900 within detector assembly 100.

Base 110 has a shoulder 135 that receives and maintains cartridge 700 in spaced relationship with respect to collector 900. Base 110 has a second shoulder 140 that receives scintillator 800. Base 110 maintains scintillator 800 in spaced relationship with respect to collector 900. A ring 145 maintains scintillator 800 against shoulder 140 and imparts a spaced relationship between scintillator 800 and cartridge 700.

Referring also to FIGS. 8–10, cartridge 700 has an input 705 through which ions enter cartridge 700 from opening 130 in cap 115, as shown in FIG. 3. Cartridge 700 includes an insulated cartridge body 710 having an interior chamber 715. Cartridge body 710 has an interior shoulder 720 which supports a conductive output plate 725. Output plate 725 is generally circular and has an edge portion 765 removed for providing clearance for an opening 767 in cartridge body 710. An insulating centering ring 730, having a central opening 735, rests on output plate 725. Centering ring 730 receives and centers an MCP 740, which rests on an inner annular edge 745 of output plate 725. A conductive input plate 750 sandwiches centering ring 730 against output plate 725. An inner annular edge 755 of input plate 750 sandwiches MCP 740 against inner annular edge 745. An insulated spacer 775 rests on input plate 750.

A conductive grid or mesh 780 rests on insulated spacer 775. Grid 780 includes crossed wires (not shown) which define a grounded plane for MCP 740. A voltage between grid 780 and the input of MCP 740 defines a “post acceleration” potential which urges ions toward and into MCP 740.

A ring 785 rests on grid 780. An insulating ring retainer 790 threadingly engages with cartridge body 710 and compresses ring 785, grid 780, spacer 775, input plate 750, MCP 740 and output plate 725 against shoulder 720, as shown in FIG. 8. Ring 785 protects grid 780 from damage which might occur if insulating ring retainer 790 is threadingly advanced directly against grid 780.

As shown in FIG. 8, cartridge body 710 has a first contact opening 712 in registration with a contact surface 727 of output plate 725. A contact member 760 extending from input plate 750 passes through a second contact opening 770 of cartridge body 710. As shown in FIG. 5, pogo pin assemblies 150 and 155 respectively contact contact surface 727 and contact member 760, producing a voltage across input plate 750 and output plate 725, hence across MCP 740.

Referring also to FIG. 9, base 110 of detector assembly 100 has upstanding registration pins 160 which mate with corresponding apertures 716 in cartridge body 710 for ensuring that the appropriate pogo pin assemblies 150, 155 contact the appropriate contact surface 727 or contact member 760. This ensures proper voltage polarity upon replacement of cartridge 700. Cartridge 700 is easily replaceable, which reduces the downtime of dependent mass spectrometry equipment.

To provide a high post acceleration potential and safeguard mass spectrometry equipment from voltage surges, the invention employs scintillator 800 to electro-optically isolate collector 900 from upstream voltages. Scintillator 800 converts electrons received from MCP 740 into photons, on the order of 400 photons per electron. The photons cross a neutral field to collector 900, which converts the photons into electrons which are summed into a charge pulse.

Referring again to FIG. 5, scintillator 800 is constructed of specially-formulated plastic scintillator material. Preferred scintillator materials include the BC-418 and BC-422 plastic scintillator materials manufactured and sold by Saint-Gobain Crystals & Detectors, Inc. These materials provide the bandwidth capability necessary for converting the electron clouds produced by MCP 740 within the typical range of frequencies encountered during mass spectrometry of very massive ions. This bandwidth extends up to about 3 GHz.

Scintillator 800 has an input working area 810 defined by ring 145. Upstream of scintillator 800, MCP 740 has an active area 746 defined by the channel array. Working areas 746 and 810 generally are coextensive. Additionally, the voltage between MCP 740 and the input of scintillator 800 accelerates the electrons from MCP 740 toward scintillator 800.

Referring to FIG. 7, pogo pin 165 applies a voltage to an input side of scintillator 800 which provides the uniform field for drawing electrons from MCP 740. The output of scintillator 800 is grounded. Thus, collector 900 is electrically isolated from scintillator 800, preventing arcing or voltage surges from being transferred to expensive instrumentation coupled to detector assembly 100.

The input side of scintillator 800 has a layer 805 of aluminum, on the order of 1000 Å, deposited thereon. Layer 805 also may be chrome. Metalized layer 805 provides a field plane for attracting electrons to scintillator 800. Metalized layer 805 also fosters converting electrons just under the surface thereof into photons.

Layer 805 also functions as a mirror to reflect photons which may have a rearward or wayward trajectory toward collector 900. The reflective properties of layer 805 approximately double electron-to-photon conversion capability of scintillator 800, thus making practical the use of scintillator 800 for electro-optically isolating high post-acceleration voltages across detector assembly 100 from collector 900, promoting high sensitivity to massive ions.

Referring again to FIG. 5, collector 900 includes a light sensing device 905 which, in response to the output photons of scintillator 800, generates on the order of 10×10⁶ electrons for every photon that strikes photomultiplier 905. Collector 900 also includes a socket 910 into which the light sensor is received. Light sensor 905 and socket 910 are electrically connected with pins (not shown) extending from light sensor 905 and received in electrical contacts (not shown) in socket 910 in a known manner.

An exemplary light sensor 905 is a photomultiplier tube, preferably a “fast” photomultiplier. “Fast” refers to the reaction time from when a photon strikes a dynode to when a resultant electron strikes an anode of the photomultiplier. For example, the reaction time of a preferred fast photomultiplier is approximately 3.2 ns FWHM. Faster reaction times improve the dynamic range of a detector because the detector may identify individual ions, rather than groups of ions.

A photomultiplier tube can be operated with ‘stage skipping’. Normally, the electron cascade initiated by emission from the photocathode is relayed sequentially through a series of dynodes in a dynode cage before it terminates at the anode to generate the response signal. In stage skipping, some of the dynodes are bypassed resulting in reduced gain, but modified frequency response characteristics. Faster reaction times may be provided in the photomultiplier by such stage skipping. resulting in reduced gain, but modified frequency response characteristics. Faster reaction times may be provided in the photomultiplier by such stage skipping.

As an alternative to the dynode-cage photomultiplier, a microchannel plate type photomultiplier can be used. In a microchannel plate device, the dynode multiplication is effected by a voltage-biased microchannel plate (MCP) that is comprised of a multitude of microchannels with surfaces that are conducive to electron emission in response to absorption of energetic particles. Electrons admitted into the channels impact the sidewalls of the microchannels and initiate an electron cascade that terminates at an anode to generate a response current, thus realizing a multiplication effect and signal gain.

The detector according to the present invention can utilize various solid state or vacuum tube photodetectors, or image intensifiers as the light sensing and conversion means, in lieu of a photomultiplier tube. More specifically, the light sensor/converter can be realized by an avalanche diode, a charge coupled device, a photovoltaic device, a CdS photoconductive cell, a PN or PIN photodiode, a phototransistor, a vacuum photodiode, or an array of any of such devices. Further, the light sensor/converter can be realized as an image intensifier in which the luminescent phosphor screen is replaced with a metal anode or a plurality of metal anodes.

A photoconductive cell, such as made by assembling two electrical contacts to a piece of CdS, can be used as a photodetector. CdS is a photosensitive semiconductor that exhibits significant changes in conductivity when illuminated with light of a certain spectral range. Thus, if the two electrical contacts formed on a CdS photocell are biased with a constant voltage difference, the current through the contacts will vary according to the intensity of light incident upon the CdS element. Similarly, if a constant current is imposed between the two contacts, the voltage between the contacts will vary according to the light intensity.

A PN photodiode is a semiconductor light detection device comprised of a PN junction and two electrical contacts. Photodiodes are commonly made from silicon, germanium, and various semiconductor compounds and alloys such as gallium arsenide (GaAs), gallium nitride (GaN), indium arsenide (InAs), and indium gallium arsenide (InGaAs). The selection of semiconductor material determines the spectral sensitivity range of the device. The diode is based on a junction or interface between two materials with distinct electrical properties. Diodes based on PN junctions are comprised of a p-type doped semiconductor region wherein the charge conduction is primarily due to positive charged particles called ‘holes,’ in contact to an n-type semiconductor region where conduction is primarily due to negatively-charged electrons. Photodiodes are essentially large-area diodes designed to enhance the absorption and generation of photons near the PN junction. Photodiodes are generally operated in reverse voltage bias in which case, with no illumination a very small thermally-generated reverse-bias or leakage current persists in the device. In contrast, under illumination the photodiode reverse current increases in proportion to the light intensity. The increase in reverse current thus provides a measure of the incident light intensity.

A PIN photodiode is similar to the PN photodiode described above, except that an undoped or intrinsic (I) region is sandwiched between the p-type and n-type regions of the device structure. This has the effect of increasing the light-absorption and generation of charge carriers, and thus the PIN diode is generally more sensitive than the simpler PN photodiode. The PIN design is useful for photodiodes made in semiconductors that have relatively weak optical absorption, such as silicon, but has less relative advantage when semiconductors with strong optical absorption, such as GaAs, are used. At any rate, not all semiconductors can be made intrinsic, and thus are not amenable to application for pin photodiodes.

Photodiodes can also be made with metal-semiconductor (Schottky barrier type) junctions, metal-oxide semiconductor (MOS) junctions, and heterojunctions between two different semiconductor materials.

An avalanche photodiode (APD) is a photodiode that is operated with sufficient reverse voltage bias to induce avalanche multiplication effects wherein photogenerated charge carriers induce the ionization of lattice atoms, creating still more charge carriers. The avalanche ionization effect thus multiplies the number of carriers generated in response to light absorption, and thereby provides an effective gain and enhancement of photodiode sensitivity. Avalanche photodiodes are designed with doping and layer thicknesses to enhance the avalanche ionization carrier multiplication effect.

A photovoltaic detector is similar in structure to a PN photodiode. In fact, a photovoltaic detector can be realized by operating a PN diode in forward bias instead of the normal reverse-voltage bias used with photodiodes, pin photodiodes, or avalanche photodiodes. In practice, no external bias need be applied to a photovoltaic detector as the photocurrent due to light absorption will self-bias the device to produce both a current and a voltage, either of which serves as an indicator of incident light intensity.

A phototransistor is a bipolar transistor that is designed to absorb light in its base region. The absorption of light generates so-called minority carriers, i.e., electrons in p-type material and/or holes in n-type material, in the base region of the transistor. This excess concentration of minority carries constitutes a photocurrent that is amplified by the inherent gain of the transistor.

Photodiodes, avalanche photodiodes and phototransistors can be integrated into one-dimensional (linear) or two-dimensional arrays to provide spatial resolution and imaging of light sources. The array can be assembled on a circuit board from discrete photodetector devices, or fabricated monolithically on a die cut from a semiconductor wafer, in which case the photodetectors are integrated on a single chip. The operation of each photodetector device element of the array is basically the same as that of the discrete device with the added feature that the detector elements of the array are interconnected so that they can be individually addressed and read.

The charge coupled device (CCD) is a monolithic integrated circuit comprised of a one- or two-dimensional layout of metal-semiconductor or metal-oxide-semiconductor capacitors made in a semiconductor wafer using microelectronics fabrication techniques. They are most commonly made in silicon. Each capacitor element serves as a pixel when the CCD is used as an imager. The electrodes of the capacitors are interconnected by conductor lines formed on the integrated circuit. For imaging applications, the CCD is configured such that an incident photon creates excess charge on a capacitor element. By applying specific voltage waveforms to the interconnect lines, charge formed under each capacitor element can be transferred to an adjacent capacitor. In this way, the photogenerated charge can be relayed to an external sampling circuit in a manner such that the photogenerated charge for each pixel can be measured in order to form an image of the photons incident on the CCD array.

The simplest vacuum tube detector is the vacuum (tube) photodiode. It functions much as the venerable vacuum tube diode based on effects first observed by Edison and developed into a useful electronic device by Fleming. The vacuum diode is comprised of cathode and anode electrodes positioned in a sealed vacuum tube. When the cathode is voltage-biased negative with respect to the anode, electrons emitted by the (heated) cathode traverse a small gap that separates the anode and cathode and thus constitute a conduction current. The vacuum diode is the vacuum tube equivalent of the semiconductor diode. In a vacuum tube photodiode, the cathode emission is enhanced by the absorption of photons. The resulting additional current due to photoemission from the cathode is thus a measure of the light intensity incident on the cathode.

Image intensifiers have features similar to those of photomultiplier tubes. Image intensifiers are comprised of an evacuated tube that is sealed at one end with a transparent faceplate and at the opposite end with a luminescent (e.g., phosphor) screen. The side of the faceplate disposed to the evacuated enclosure is coated with a photoemissive material and thus serves as a photocathode. Light is made incident upon the faceplate and photons of certain spectral characteristics stimulate emission of electrons from the photocathode. A voltage imposed along the axis of the tube accelerates the electrons emitted from the photocathode toward the luminescent screen where their impact generates photons to create an image that replicates the pattern formed by radiation incident on the faceplate. In this way, the image projected onto the photocathode faceplate is intensified on the luminescent screen. For the present invention as related to mass spectrometry applications, the imaging of scintillator light is in itself not useful. Therefore, for the mass spectrometer according to the present invention, the luminescent screen is replaced with a metal anode or an array of metal anodes, so that the electrons emitted from the photocathode are accelerated to the anode(s) and upon impact with the anode(s) induce a current that serves as an indicator of radiation incident on the faceplate photocathode. Image intensifiers have been developed for more than five decades as the basic component of night vision devices, and their degrees of sophistication are commonly classified as Generation 0, Generation 1, Generation 2, etc. In Generation 0 image intensifier devices, the scene must be illuminated with an external light source. Generation 1 image intensifiers are sufficiently sensitive so that the external illumination source can be dispensed with for many night vision applications. Generation 2 image intensifiers use a microchannel plate to amplify the electrons emitted from the photocathode, thus providing gain. As such, and when used with an anode in place of a luminescent screen, these devices resemble conventional microchannel plate photomultiplier tubes. Generation 3 image intensifiers use a gallium arsenide based photocathode which provides improved resolution and sensitivity.

Referring to FIG. 10A, the invention provides improved MCP sensitivity by depositing on the surface 744 of MCP 740 a coating 742. Coating 742 also extends into each channel 20 of MCP 740. Coating 742 enhances the first strike conversion capability, or ability to convert ions into electrons, of MCP 740. An exemplary coating 742 is magnesium oxide (MgO). Magnesium oxide has been found to provide superior secondary electron emissivity properties over other coatings, such as aluminum oxide. Coating 742 also may be tin oxide (SnO₂), quartz (SiO₂), barium fluoride (BaF₂), rubidium tin (Rb₃Sn), beryllium oxide (BeO), or diamond.

Referring to FIG. 11, in operation, detector assembly 100 may be used to detect, for example, large negative ions. Ionization source S has multiple plates (not shown) across which a voltage repels only negative ions −i into the field free drift tube. A net +10 kV voltage exists across the gap between ionization source S and MCP 740, between ionization source output S_o, which is at ground, and MCP input voltage P_mi Ions −i are attracted to MCP 740 by the net positive voltage bias with respect to MCP 740. The voltage between ionization source S and MCP 740 temporally separates negative ions −i by mass. Ions −i may be post-accelerated with a high voltage to increase overall ion detection efficiency.

A net positive potential, such as +1 kV, across MCP 740, i.e. between MCP input (P_mi=+10 kV) and MCP output (P_mo=+11 kV), accelerates electrons −e, converted from ions −i, as discussed above, through MCP 740. A net positive voltage, such as +2 kV, between MCP 740 and scintillator 800, i.e., between MCP output (P_mo=+11 kV) and scintillator input (P_si=+13 kV), accelerates electrons −e from MCP 740 toward scintillator 800.

Scintillator 800 converts the electrons −e into photons P. Photons P are insensitive to electrical fields, therefore the voltage across scintillator 800 may drop to ground. Photons P strike collector 900.

The light sensor (not shown in FIG. 11, but see FIG. 5) of collector 900 converts photons P into electrons (not shown). A net positive voltage across collector 900, such as+600 kV, from collector input (P_co=−600 kV) to the grounded output, urges electrons through collector 900. The electrons are summed into a charge pulse at the output C.

Referring to FIG. 12, detector assembly 100 is bi-polar in that detector assembly 100 may be operated to detect large positive ions as well as negative ions. Similar to the above, ionization source S directs only positive ions +i toward MCP 740. A net −10 kV voltage between ionization source S and MCP 740, i.e., between ionization source output S_o and MCP input voltage P_mi. Ions +i are attracted to MCP 740 by the net negative voltage bias with respect to MCP 740.

A net positive potential, such as+1 kV, across MCP 740, between MCP input voltage P_mi (e.g. −10 kV) and MCP output voltage P_mo (e.g. −9 kV), likewise accelerates electrons −e through MCP 740.

Electrons −e from MCP 740 travel toward scintillator 800, driven by a net positive voltage, such as+3 kV, between MCP 740 and scintillator 800, i.e. between MCP output (P_mo=−9 kV) and scintillator input (P_si=−6 kV).

Scintillator 800 converts electrons −e into photons P. The output of scintillator 800 is grounded.

The light sensor (not shown in FIG. 12, but see FIG. 5) in collector 900 converts photons P into electrons (not shown), which are urged therethrough with a net +600 kV voltage and summed into a charge pulse at output C.

While the foregoing is considered to be exemplary of the invention, various changes and modifications of feature of the invention may be made without departing from the invention. The appended claims cover such changes and modifications as fall within the true spirit and scope of the invention.

Claims

1. A detector for a time-of-flight mass spectrometer comprising: an electron multiplier, for converting a charged particle into a multiplicity of electrons;a scintillator, for converting the multiplicity of electrons into a multiplicity of photons; anda collector disposed for receiving the multiplicity of photons and adapted for reconverting said photons into a second multiplicity of electrons and integrating said second multiplicity of electrons into a charge pulse corresponding to the mass of the charged particle;wherein said collector comprises a light sensor selected from the group consisting of an avalanche photodiode, an avalanche photodiode array, a charge coupled device, a photovoltaic device, a CdS photoconductive cell, a PN photodiode, a PIN photodiode, a phototransistor, a vacuum photodiode, an image intensifier tube having a metal anode in place of a luminescent screen, a microchannel plate type photomultiplier, and a photomultiplier tube incorporating stage skipping.

2. The detector set forth in claim 1, wherein said electron multiplier comprises a coating formed on a surface thereof, said coating being formed of a material selected from the group consisting of aluminum oxide (Al2O3), magnesium oxide (MgO), tin oxide (SnO2), quartz (SiO2), barium fluoride (BaF2), rubidium tin (Rb3Sn), beryllium oxide (BeO), diamond and combinations thereof.

3. The detector set forth in claim 1, wherein said electron multiplier comprises a microchannel plate.

4. The detector set forth in claim 1 comprising a cartridge configured to receive said microchannel plate, said cartridge being readily removable from and installable in said detector.

5. The detector set forth in claim 1, wherein said scintillator is configured to provide a frequency bandwidth which accommodates arrival times of the multiplicity of electrons.

6. The detector set forth in claim 1, wherein said scintillator is constructed from a plastic scintillator material.

7. The detector set forth in claim 1, further comprising a conductive coating on said scintillator configured to internally reflect photons generated therein.

8. The detector set forth in claim 7, wherein the conductive coating on said scintillator is selected from the group consisting of aluminum, chrome and combinations thereof.

9. The detector set forth in claim 1 wherein the light sensor is an avalanche photodiode.

10. The detector set forth in claim 1 wherein the light sensor is an avalanche photodiode array.

11. The detector set forth in claim 1 wherein the light sensor is a charge coupled device.

12. The detector set forth in claim 1 wherein the light sensor is a photovoltaic device.

13. The detector set forth in claim 1 wherein the light sensor is a CdS photoconductive cell.

14. The detector set forth in claim 1 wherein the light sensor is a PIN photodiode.

15. The detector set forth in claim 1 wherein the light sensor is a phototransistor.

16. The detector set forth in claim 1 wherein the light sensor is a vacuum photodiode.

17. The detector set forth in claim 1 wherein the light sensor is an image intensifier tube having a metal anode in place of a luminescent screen.

18. The detector set forth in claim 1 wherein the light sensor is a microchannel plate type photomultiplier.

19. The detector set forth in claim 1 wherein the light sensor is a photomultiplier tube incorporating stage skipping.

20. A detector for a time-of-flight mass spectrometer comprising: a microchannel plate disposed for receiving a charged particle and formed for converting the charged particle into a multiplicity of electrons;a scintillator disposed for receiving the multiplicity of electrons from said microchannel plate for converting the multiplicity of electrons into a multiplicity of photons; anda collector disposed for receiving the multiplicity of photons and adapted for reconverting the multiplicity of photons into a second multiplicity of electrons and integrating said second multiplicity of electrons into a charge pulse corresponding to the mass of the charged particle;wherein said collector comprises a light sensor selected from the group consisting of an avalanche photodiode, an avalanche photodiode array, a charge coupled device, a photovoltaic device, a CdS photoconductive cell, a PN photodiode, a PIN photodiode, a phototransistor, a vacuum photodiode, an image intensifier tube having a metal anode in place of a luminescent screen, a microchannel plate type photomultiplier, and a photomultiplier tube incorporating stage skipping.