Oligonucleotide agonists targeting progranulin

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a direct national of and claims priority to European Patent Application No. 20174322.6 filed May 13, 2020, and to European Patent Application No. 20210822.1 filed Nov. 30, 2020, the entire disclosures of which are incorporated herein by this reference.

REFERENCE TO A SEQUENCE LISTING SUBMITTED VIA EFS-WEB

The content of the ASCII text file of the sequence listing named “Hoffmann-La Roche Inc. updated sequence listing 06022021” which was created on Jun. 11, 2021, and is 799.722 bytes in size submitted electronically via EFS-Web with this U.S. application is incorporated by reference in its entirety.

FIELD OF INVENTION

The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency.

BACKGROUND

Progranulin (PGRN) is a highly conserved secreted protein that is expressed in multiple cell types, both in the CNS and in peripheral tissues.

Deficiency of the secreted protein progranulin in the central nervous system causes the neurodegenerative disease fronto temporal dementia (FTD). Pathogenic progranulin (GRN) mutations lead to a loss of about 50% in progranulin levels through haploinsufficiency and to intraneuronal aggregation of TDP-43 protein. Progranulin plays a supportive and protective role in numerous processes within the brain, including neurite outgrowth, synapse biology, response to exogenous stressors, lysosomal function, neuroinflammation, and angiogenesis in both cell autonomous and non-autonomous manners.

In several neurodegenerative diseases TDP-43 is a common denominator. TDP-43 pathology is associated with cytoplasmic TDP-43 aggregation. For example, more than 95% of ALS patients display pathological mislocalization of TDP-43 and several mutations in its gene cause familial ALS.

The presence of cytoplasmic TDP-43 aggregates is associated with a concomitant loss of nuclear TDP-43, and there is evidence of both loss of function and gain of function associated pathophysiologies.

Both directly and via its conversion to granulins, progranulin regulates lysosomal function, cell growth, survival, repair, and inflammation. Progranulin has a major role in regulation of lysosomal function associated microglial responses in the CNS. Autosomal dominant mutations of the progranulin (GRN) gene leading to protein haploinsufficiency are linked to familial frontotemporal dementia with neuropathologic frontotemporal lobar degeneration (FTLD) associated with accumulation of TAR-DNA binding protein of 43 kDA (TDP-43) inclusions (FTLD-TDP). Homozygous GRN mutations are linked to neuronal ceroid lipofuscinosis (NCL) (Townley, et al., Neurology. 2018 Jun. 12; 90 (24): 1127).

Mutations in the progranulin gene (GRN) have recently been identified as a cause of about 5% of all FTD, including some sporadic cases. Recent studies using mouse models has defined the expression of PGRN in the brain (Petkau et al., 2010). PGRN is expressed late in neurodevelopment, localizing with markers of mature neurons. PGRN is expressed in neurons in most brain regions, with highest expression in the thalamus, hippocampus, and cortex. Microglia cells also express progranulin, and the level of expression is upregulated by microglial activation. Around 70 different GRN mutations have been identified in FTD and all reduce progranulin levels or result in loss of progranulin function.

WO 2020/077165 reports on AAV particle delivery of therapeutic nucleic acids, and lists progranulin as a potential gene of interest.

There is therefore an urgent need for therapeutic agents which can increase the expression of progranulin.

SUMMARY OF INVENTION

The invention provides antisense oligonucleotide agonists of progranulin or antisense oligonucleotide progranulin agonists—i.e. antisense oligonucleotides which are complementary to a progranulin nucleic acid sequence, and which are capable of up-regulating the expression of progranulin. Alternatively stated, the invention provides antisense oligonucleotide positive modulators (i.e. agonists) of progranulin.

The antisense oligonucleotides of the invention may therefore be used to restore progranulin expression in cells which exhibit progranulin haploinsufficiency, or to enhance expression of progranulin in cells.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 8-40 nucleotides in length and comprises a contiguous nucleotide sequence of 8-40 nucleotides in length which are complementary, such as fully complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-40 nucleotides in length and comprises a contiguous nucleotide sequence of 12-40 nucleotides in length which are complementary, such as fully complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-20 nucleotides in length and comprises a contiguous nucleotide sequence of 12-20 nucleotides in length which are complementary, such as fully complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 14-18 nucleotides in length and comprises a contiguous nucleotide sequence of 14-18 nucleotides in length which are complementary, such as fully complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-18 nucleotides in length and comprises a contiguous nucleotide sequence of 12-18 nucleotides in length which are complementary, such as fully complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 8-40 nucleotides in length and comprises a contiguous nucleotide sequence of 8-40 nucleotides in length which are complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 683, 684, 685, 686, 687 and 688.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-40 nucleotides in length and comprises a contiguous nucleotide sequence of 12-40 nucleotides in length which are complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 683, 684, 685, 686, 687 and 688.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-20 nucleotides in length and comprises a contiguous nucleotide sequence of 12-20 nucleotides in length which are complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 683, 684, 685, 686, 687 and 688.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 14-18 nucleotides in length and comprises a contiguous nucleotide sequence of 14-18 nucleotides in length which are complementary, such as fully complementary, to a to a sequence selected from the group consisting of SEQ ID NO 683, 684, 685, 686, 687 and 688.

The invention provides an antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 12-18 nucleotides in length and comprises a contiguous nucleotide sequence of 12-18 nucleotides in length which are complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 683, 684, 685, 686, 687 and 688.

The antisense oligonucleotide progranulin agonist may be 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 or 40 nucleotides in length. In some embodiments the antisense oligonucleotide, or contiguous nucleotide sequence thereof, is 8-40, 12-40, 12-20, 14-18, 12-18 or 16-18 nucleotides in length.

The contiguous nucleotide sequence may be 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 or 40 nucleotides in length. In some embodiments, the contiguous nucleotide sequence is of a length of at least 12 nucleotides in length, such as 12-16 or 12-18 nucleotides in length.

In some embodiments, the contiguous nucleotide sequence is the same length as the antisense oligonucleotide progranulin agonist.

In some embodiments the antisense oligonucleotide consists of the contiguous nucleotide sequence.

In some embodiments the antisense oligonucleotide is the contiguous nucleotide sequence.

In some embodiments, the contiguous nucleotide sequence is fully complementary to a sequence selected from the group consisting of SEQ ID NO 343-682.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to the human progranulin mature mRNA (SEQ ID NO: 1).

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to the human progranulin precursor-mRNA (pre-mRNA) (SEQ ID NO: 3949).

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a 5′UTR region of a human progranulin mature mRNA transcript. Herein the 5′ UTR is defined as nucleotides 38 to 241 according to RefSeq NM_002807.3 (SEQ ID NO 1).

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to nucleotides 38-246 of SEQ ID NO 1.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to SEQ ID NO 689.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to SEQ ID NO 2.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to SEQ ID NO 683.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 343-586.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 568, SEQ ID NO 571, SEQ ID NO 575, SEQ ID NO 576, SEQ ID NO 577, SEQ ID NO 578, SEQ ID NO 584, & SEQ ID NO 586.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 8 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 9 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 10 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 11 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 12 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 13 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 14 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 15 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 16 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is selected from SEQ ID NO 105, SEQ ID NO 106, SEQ ID NO 110, SEQ ID NO 113, SEQ ID NO 114, SEQ ID NO 231 and SEQ ID NO 241 or at least 8 or at least 10 contiguous nucleotides thereof.

In some embodiments the contiguous nucleotide sequence is SEQ ID NO 106.

In some embodiments the contiguous nucleotide sequence is SEQ ID NO 110.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a 3′UTR region of a human progranulin mature mRNA transcript. Herein the 3′ UTR is defined as nucleotides 2044 to 2346 according to RefSeq NM_002807.3 (SEQ ID NO 1).

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to nucleotides 2039-2346 of SEQ ID NO 1.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, and SEQ ID NO 688.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 587-682.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 607, SEQ ID NO 608, SEQ ID NO 609, SEQ ID NO 610, SEQ ID NO 611, SEQ ID NO 612, SEQ ID NO 619, SEQ ID NO 620, SEQ ID NO 633, SEQ ID NO 640, SEQ ID NO 641, SEQ ID NO 645, SEQ ID NO 651, and SEQ ID NO 652.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 2040-3386.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID NO 2040-3386 or at least 8 contiguous nucleotides thereof.

In some embodiments, the contiguous nucleotide sequence is complementary, such as fully complementary, to a sequence selected from the group consisting of SEQ ID 2321, SEQ ID 2322, SEQ ID 2324, SEQ ID 2328, SEQ ID 2329, SEQ ID 2331, SEQ ID 2334, SEQ ID 2335, SEQ ID 2336, SEQ ID 2337, SEQ ID 2338, SEQ ID 2339, SEQ ID 2340, SEQ ID 2341, SEQ ID 2342, SEQ ID 2345, SEQ ID 2346, SEQ ID 2347, SEQ ID 2348, SEQ ID 2349, SEQ ID 2350, SEQ ID 2351, SEQ ID 2352, SEQ ID 2353, SEQ ID 2354, SEQ ID 2355, SEQ ID 2356, SEQ ID 2357, SEQ ID 2358, SEQ ID 2359, SEQ ID 2360, SEQ ID 2361, SEQ ID 2362, SEQ ID 2364, SEQ ID 2365, SEQ ID 2366, SEQ ID 2367, SEQ ID 2368, SEQ ID 2369, SEQ ID 2370, SEQ ID 2371, SEQ ID 2372, SEQ ID 2373, SEQ ID 2374, SEQ ID 2375, SEQ ID 2376, SEQ ID 2377, SEQ ID 2378, SEQ ID 2379, SEQ ID 2380, SEQ ID 2381, SEQ ID 2384, SEQ ID 2386, SEQ ID 2387, SEQ ID 2388, SEQ ID 2389, SEQ ID 2390, SEQ ID 2392, SEQ ID 2393, SEQ ID 2394, SEQ ID 2395, SEQ ID 2396, SEQ ID 2397, SEQ ID 2398, SEQ ID 2399, SEQ ID 2400, SEQ ID 2401, SEQ ID 2403, SEQ ID 2404, SEQ ID 2405, SEQ ID 2406, SEQ ID 2407, SEQ ID 2408, SEQ ID 2410, SEQ ID 2411, SEQ ID 2413, SEQ ID 2414, SEQ ID 2415, SEQ ID 2416, SEQ ID 2418, SEQ ID 2419, SEQ ID 2421, SEQ ID 2424, SEQ ID 2425, SEQ ID 2426, SEQ ID 2427, SEQ ID 2428, SEQ ID 2429, SEQ ID 2430, SEQ ID 2431, SEQ ID 2432, SEQ ID 2433, SEQ ID 2434, SEQ ID 2435, SEQ ID 2436, SEQ ID 2437, SEQ ID 2438, SEQ ID 2439, SEQ ID 2440, SEQ ID 2441, SEQ ID 2442, SEQ ID 2443, SEQ ID 2444, SEQ ID 2445, SEQ ID 2446, SEQ ID 2447, SEQ ID 2448, SEQ ID 2449, SEQ ID 2450, SEQ ID 2451, SEQ ID 2452, SEQ ID 2453, SEQ ID 2454, SEQ ID 2455, SEQ ID 2456, SEQ ID 2457, SEQ ID 2458, SEQ ID 2459, SEQ ID 2460, SEQ ID 2461, SEQ ID 2462, SEQ ID 2463, SEQ ID 2464, SEQ ID 2465, SEQ ID 2466, SEQ ID 2467, SEQ ID 2468, SEQ ID 2469, SEQ ID 2470, SEQ ID 2471, SEQ ID 2472, SEQ ID 2473, SEQ ID 2474, SEQ ID 2475, SEQ ID 2476, SEQ ID 2477, SEQ ID 2478, SEQ ID 2479, SEQ ID 2481, SEQ ID 2482, SEQ ID 2483, SEQ ID 2484, SEQ ID 2485, SEQ ID 2487, SEQ ID 2489, SEQ ID 2490, SEQ ID 2491, SEQ ID 2492, SEQ ID 2493, SEQ ID 2494, SEQ ID 2495, SEQ ID 2496, SEQ ID 2497, SEQ ID 2498, SEQ ID 2499, SEQ ID 2501, SEQ ID 2502, SEQ ID 2503, SEQ ID 2504, SEQ ID 2505, SEQ ID 2506, SEQ ID 2507, SEQ ID 2508, SEQ ID 2509, SEQ ID 2510, SEQ ID 2511, SEQ ID 2512, SEQ ID 2513, SEQ ID 2514, SEQ ID 2515, SEQ ID 2516, SEQ ID 2518, SEQ ID 2519, SEQ ID 2520, SEQ ID 2521, SEQ ID 2522, SEQ ID 2523, SEQ ID 2524, SEQ ID 2525, SEQ ID 2526, SEQ ID 2527, SEQ ID 2528, SEQ ID 2531, SEQ ID 2533, SEQ ID 2534, SEQ ID 2535, SEQ ID 2536, SEQ ID 2537, SEQ ID 2538, SEQ ID 2540, SEQ ID 2541, SEQ ID 2542, SEQ ID 2544, SEQ ID 2546, SEQ ID 2547, SEQ ID 2549, SEQ ID 2550, SEQ ID 2551, SEQ ID 2553, SEQ ID 2554, SEQ ID 2555, SEQ ID 2556, SEQ ID 2557, SEQ ID 2560, SEQ ID 2561, SEQ ID 2562, SEQ ID 2563, SEQ ID 2565, SEQ ID 2566, SEQ ID 2567, SEQ ID 2572, SEQ ID 2573, SEQ ID 2574, SEQ ID 2575, SEQ ID 2576, SEQ ID 2577, SEQ ID 2578, SEQ ID 2579, SEQ ID 2580, SEQ ID 2581, SEQ ID 2582, SEQ ID 2583, SEQ ID 2584, SEQ ID 2585, SEQ ID 2586, SEQ ID 2588, SEQ ID 2589, SEQ ID 2590, SEQ ID 2591, SEQ ID 2592, SEQ ID 2593, SEQ ID 2594, SEQ ID 2595, SEQ ID 2596, SEQ ID 2597, SEQ ID 2598, SEQ ID 2599, SEQ ID 2601, SEQ ID 2602, SEQ ID 2603, SEQ ID 2604, SEQ ID 2606, SEQ ID 2610, SEQ ID 2613, SEQ ID 2614, SEQ ID 2615, SEQ ID 2619, SEQ ID 2622, SEQ ID 2623, SEQ ID 2624, SEQ ID 2625, SEQ ID 2626, SEQ ID 2627, SEQ ID 2628, SEQ ID 2629, SEQ ID 2630, SEQ ID 2631, SEQ ID 2632, SEQ ID 2633, SEQ ID 2634, SEQ ID 2635, SEQ ID 2636, SEQ ID 2637, SEQ ID 2638, SEQ ID 2639, SEQ ID 2640, SEQ ID 2641, SEQ ID 2642, SEQ ID 2643, SEQ ID 2644, SEQ ID 2645, SEQ ID 2646, SEQ ID 2647, SEQ ID 2648, SEQ ID 2649, SEQ ID 2650, SEQ ID 2651, SEQ ID 2652, SEQ ID 2653, SEQ ID 2654, SEQ ID 2655, SEQ ID 2656, SEQ ID 2658, SEQ ID 2659, SEQ ID 2660, SEQ ID 2661, SEQ ID 2662, SEQ ID 2663, SEQ ID 2664, SEQ ID 2665, SEQ ID 2666, SEQ ID 2667, SEQ ID 2668, SEQ ID 2669, SEQ ID 2670, SEQ ID 2671, SEQ ID 2672, SEQ ID 2673, SEQ ID 2674, SEQ ID 2675, SEQ ID 2676, SEQ ID 2677, SEQ ID 2678, SEQ ID 2679, SEQ ID 2680, SEQ ID 2681, SEQ ID 2682, SEQ ID 2683, SEQ ID 2684, SEQ ID 2685, SEQ ID 2686, SEQ ID 2687, SEQ ID 2688, SEQ ID 2689, SEQ ID 2690, SEQ ID 2691, SEQ ID 2693, SEQ ID 2694, SEQ ID 2695, SEQ ID 2696, SEQ ID 2697, SEQ ID 2698, SEQ ID 2699, SEQ ID 2700, SEQ ID 2701, SEQ ID 2702, SEQ ID 2703, SEQ ID 2704, SEQ ID 2705, SEQ ID 2706, SEQ ID 2707, SEQ ID 2708, SEQ ID 2709, SEQ ID 2710, SEQ ID 2711, SEQ ID 2712, SEQ ID 2713, SEQ ID 2714, SEQ ID 2715, SEQ ID 2716, SEQ ID 2717, SEQ ID 2718, SEQ ID 2719, SEQ ID 2720, SEQ ID 2721, SEQ ID 2722, SEQ ID 2723, SEQ ID 2726, SEQ ID 2727, SEQ ID 2728, SEQ ID 2729, SEQ ID 2730, SEQ ID 2733, SEQ ID 2734, SEQ ID 2735, SEQ ID 2736, SEQ ID 2737, SEQ ID 2738, SEQ ID 2739, SEQ ID 2740, SEQ ID 2741, SEQ ID 2742, SEQ ID 2743, SEQ ID 2744, SEQ ID 2745, SEQ ID 2746, SEQ ID 2747, SEQ ID 2748, SEQ ID 2749, SEQ ID 2750, SEQ ID 2751, SEQ ID 2752, SEQ ID 2753, SEQ ID 2754, SEQ ID 2755, SEQ ID 2756, SEQ ID 2757, SEQ ID 2758, SEQ ID 2759, SEQ ID 2760, SEQ ID 2761, SEQ ID 2762, SEQ ID 2763, SEQ ID 2764, SEQ ID 2765, SEQ ID 2766, SEQ ID 2767, SEQ ID 2768, SEQ ID 2769, SEQ ID 2770, SEQ ID 2771, SEQ ID 2772, SEQ ID 2773, SEQ ID 2774, SEQ ID 2775, SEQ ID 2815, SEQ ID 2816, SEQ ID 2817, SEQ ID 2818, SEQ ID 2819, SEQ ID 2820, SEQ ID 2821, SEQ ID 2822, SEQ ID 2823, SEQ ID 2824, SEQ ID 2825, SEQ ID 2826, SEQ ID 2827, SEQ ID 2828, SEQ ID 2829, SEQ ID 2830, SEQ ID 2831, SEQ ID 2832, SEQ ID 2833, SEQ ID 2834, SEQ ID 2835, SEQ ID 2836, SEQ ID 2837, SEQ ID 2838, SEQ ID 2839, SEQ ID 2840, SEQ ID 2841, SEQ ID 2842, SEQ ID 2843, SEQ ID 2844, SEQ ID 2845, SEQ ID 2847, SEQ ID 2848, SEQ ID 2849, SEQ ID 2850, SEQ ID 2851, SEQ ID 2852, SEQ ID 2853, SEQ ID 2854, SEQ ID 2855, SEQ ID 2858, SEQ ID 2859, SEQ ID 2860, SEQ ID 2861, SEQ ID 2862, SEQ ID 2863, SEQ ID 2864, SEQ ID 2865, SEQ ID 2866, SEQ ID 2867, SEQ ID 2868, SEQ ID 2869, SEQ ID 2870, SEQ ID 2871, SEQ ID 2872, SEQ ID 2873, SEQ ID 2874, SEQ ID 2875, SEQ ID 2876, SEQ ID 2878, SEQ ID 2879, SEQ ID 2880, SEQ ID 2881, SEQ ID 2882, SEQ ID 2883, SEQ ID 2884, SEQ ID 2885, SEQ ID 2886, SEQ ID 2887, SEQ ID 2888, SEQ ID 2889, SEQ ID 2890, SEQ ID 2891, SEQ ID 2892, SEQ ID 2893, SEQ ID 2894, SEQ ID 2895, SEQ ID 2896, SEQ ID 2897, SEQ ID 2898, SEQ ID 2899, SEQ ID 2900, SEQ ID 2901, SEQ ID 2902, SEQ ID 2903, SEQ ID 2904, SEQ ID 2905, SEQ ID 2906, SEQ ID 2907, SEQ ID 2908, SEQ ID 2909, SEQ ID 2910, SEQ ID 2911, SEQ ID 2912, SEQ ID 2913, SEQ ID 2914, SEQ ID 2915, SEQ ID 2916, SEQ ID 2917, SEQ ID 2918, SEQ ID 2919, SEQ ID 2920, SEQ ID 2921, SEQ ID 2922, SEQ ID 2923, SEQ ID 2924, SEQ ID 2925, SEQ ID 2926, SEQ ID 2927, SEQ ID 2928, SEQ ID 2929, SEQ ID 2930, SEQ ID 2931, SEQ ID 2932, SEQ ID 2934, SEQ ID 2935, SEQ ID 2936, SEQ ID 2937, SEQ ID 2938, SEQ ID 2939, SEQ ID 2940, SEQ ID 2941, SEQ ID 2942, SEQ ID 2943, SEQ ID 2944, SEQ ID 2945, SEQ ID 2946, SEQ ID 2947, SEQ ID 2948, SEQ ID 2949, SEQ ID 2950, SEQ ID 2951, SEQ ID 2953, SEQ ID 2954, SEQ ID 2955, SEQ ID 2956, SEQ ID 2957, SEQ ID 2958, SEQ ID 2960, SEQ ID 2961, SEQ ID 2963, SEQ ID 2964, SEQ ID 2965, SEQ ID 2966, SEQ ID 2967, SEQ ID 2969, SEQ ID 2970, SEQ ID 2971, SEQ ID 2972, SEQ ID 2973, SEQ ID 2974, SEQ ID 2975, SEQ ID 2976, SEQ ID 2977, SEQ ID 2978, SEQ ID 2979, SEQ ID 2980, SEQ ID 2981, SEQ ID 2982, SEQ ID 2983, SEQ ID 2984, SEQ ID 2985, SEQ ID 3053, SEQ ID 3054, SEQ ID 3055, SEQ ID 3056, SEQ ID 3057, SEQ ID 3058, SEQ ID 3059, SEQ ID 3060, SEQ ID 3061, SEQ ID 3062, SEQ ID 3063, SEQ ID 3064, SEQ ID 3065, SEQ ID 3066, SEQ ID 3068, SEQ ID 3069, SEQ ID 3070, SEQ ID 3071, SEQ ID 3072, SEQ ID 3073, SEQ ID 3074, SEQ ID 3075, SEQ ID 3076, SEQ ID 3077, SEQ ID 3078, SEQ ID 3079, SEQ ID 3080, SEQ ID 3081, SEQ ID 3082, SEQ ID 3083, SEQ ID 3084, SEQ ID 3085, SEQ ID 3086, SEQ ID 3087, SEQ ID 3088, SEQ ID 3089, SEQ ID 3090, SEQ ID 3091, SEQ ID 3092, SEQ ID 3093, SEQ ID 3094, SEQ ID 3095, SEQ ID 3097, SEQ ID 3098, SEQ ID 3099, SEQ ID 3100, SEQ ID 3102, SEQ ID 3103, SEQ ID 3104, SEQ ID 3105, SEQ ID 3106, SEQ ID 3107, SEQ ID 3108, SEQ ID 3109, SEQ ID 3110, SEQ ID 3112, SEQ ID 3113, SEQ ID 3115, SEQ ID 3116, SEQ ID 3117, SEQ ID 3119, SEQ ID 3120, SEQ ID 3121, SEQ ID 3122, SEQ ID 3123, SEQ ID 3124, SEQ ID 3125, SEQ ID 3126, SEQ ID 3127, SEQ ID 3128, SEQ ID 3129, SEQ ID 3130, SEQ ID 3131, SEQ ID 3132, SEQ ID 3133, SEQ ID 3134, SEQ ID 3135, SEQ ID 3136, SEQ ID 3137, SEQ ID 3138, SEQ ID 3139, SEQ ID 3140, SEQ ID 3141, SEQ ID 3142, SEQ ID 3143, SEQ ID 3144, SEQ ID 3145, SEQ ID 3146, SEQ ID 3147, SEQ ID 3148, SEQ ID 3149, SEQ ID 3150, SEQ ID 3151, SEQ ID 3152, SEQ ID 3153, SEQ ID 3154, SEQ ID 3155, SEQ ID 3156, SEQ ID 3157, SEQ ID 3158, SEQ ID 3159, SEQ ID 3160, SEQ ID 3161, SEQ ID 3162, SEQ ID 3163, SEQ ID 3164, SEQ ID 3165, SEQ ID 3166, SEQ ID 3167, SEQ ID 3168, SEQ ID 3169, SEQ ID 3170, SEQ ID 3171, SEQ ID 3172, SEQ ID 3173, SEQ ID 3174, SEQ ID 3175, SEQ ID 3176, SEQ ID 3177, SEQ ID 3178, SEQ ID 3179, SEQ ID 3180, SEQ ID 3181, SEQ ID 3182, SEQ ID 3183, SEQ ID 3184, SEQ ID 3185, SEQ ID 3186, SEQ ID 3187, SEQ ID 3188, SEQ ID 3189, SEQ ID 3190, SEQ ID 3191, SEQ ID 3192, SEQ ID 3193, SEQ ID 3194, SEQ ID 3195, SEQ ID 3196, SEQ ID 3197, SEQ ID 3198, SEQ ID 3199, SEQ ID 3200, SEQ ID 3201, SEQ ID 3202, SEQ ID 3203, SEQ ID 3204, SEQ ID 3205, SEQ ID 3206, SEQ ID 3207, SEQ ID 3208, SEQ ID 3209, SEQ ID 3210, SEQ ID 3211, SEQ ID 3212, SEQ ID 3213, SEQ ID 3214, SEQ ID 3215, SEQ ID 3216, SEQ ID 3217, SEQ ID 3218, SEQ ID 3219, SEQ ID 3220, SEQ ID 3221, SEQ ID 3222, SEQ ID 3223, SEQ ID 3224, SEQ ID 3225, SEQ ID 3226, SEQ ID 3227, SEQ ID 3228, SEQ ID 3229, SEQ ID 3230, SEQ ID 3231, SEQ ID 3232, SEQ ID 3233, SEQ ID 3234, SEQ ID 3235, SEQ ID 3236, SEQ ID 3237, SEQ ID 3238, SEQ ID 3239, SEQ ID 3240, SEQ ID 3241, SEQ ID 3242, SEQ ID 3243, SEQ ID 3244, SEQ ID 3245, SEQ ID 3246, SEQ ID 3248, SEQ ID 3249, SEQ ID 3250, SEQ ID 3251, SEQ ID 3252, SEQ ID 3253, SEQ ID 3254, SEQ ID 3255, SEQ ID 3256, SEQ ID 3257, SEQ ID 3258, SEQ ID 3259, SEQ ID 3260, SEQ ID 3261, SEQ ID 3262, SEQ ID 3263, SEQ ID 3264, SEQ ID 3265, SEQ ID 3266, SEQ ID 3267, SEQ ID 3268, SEQ ID 3269, SEQ ID 3270, SEQ ID 3271, SEQ ID 3272, SEQ ID 3273, SEQ ID 3275, SEQ ID 3276, SEQ ID 3277, SEQ ID 3278, SEQ ID 3279, SEQ ID 3280, SEQ ID 3282, SEQ ID 3284, SEQ ID 3285, SEQ ID 3286, SEQ ID 3287, SEQ ID 3288, SEQ ID 3289, SEQ ID 3291, SEQ ID 3292, SEQ ID 3293, SEQ ID 3294, SEQ ID 3295, SEQ ID 3296, SEQ ID 3297, SEQ ID 3298, SEQ ID 3299, SEQ ID 3300, SEQ ID 3301, SEQ ID 3302, SEQ ID 3303, SEQ ID 3304, SEQ ID 3305, SEQ ID 3306, SEQ ID 3307, SEQ ID 3308, SEQ ID 3309, SEQ ID 3310, SEQ ID 3311, SEQ ID 3312, SEQ ID 3313, SEQ ID 3314, SEQ ID 3315, SEQ ID 3316, SEQ ID 3317, SEQ ID 3318, SEQ ID 3320, SEQ ID 3321, SEQ ID 3322, SEQ ID 3323, SEQ ID 3324, SEQ ID 3325, SEQ ID 3326, SEQ ID 3327, SEQ ID 3329, SEQ ID 3331, SEQ ID 3332, SEQ ID 3333, SEQ ID 3334, SEQ ID 3335, SEQ ID 3336, SEQ ID 3337, SEQ ID 3338, SEQ ID 3339, SEQ ID 3340, SEQ ID 3342, SEQ ID 3343, SEQ ID 3344, SEQ ID 3345, SEQ ID 3346, SEQ ID 3347, SEQ ID 3348, SEQ ID 3349, SEQ ID 3350, SEQ ID 3351, SEQ ID 3352, SEQ ID 3353, SEQ ID 3354, SEQ ID 3355, SEQ ID 3356, SEQ ID 3357, SEQ ID 3358, SEQ ID 3359, SEQ ID 3360, SEQ ID 3361, SEQ ID 3362, SEQ ID 3363, SEQ ID 3364, SEQ ID 3365, SEQ ID 3366, SEQ ID 3367, SEQ ID 3368, SEQ ID 3369, SEQ ID 3370, SEQ ID 3371, SEQ ID 3390, SEQ ID 3391, SEQ ID 3392, SEQ ID 3393, SEQ ID 3394, SEQ ID 3395, SEQ ID 3396, SEQ ID 3397, SEQ ID 3398, SEQ ID 3399, SEQ ID 3400, SEQ ID 3401, SEQ ID 3402, SEQ ID 3403, SEQ ID 3404, SEQ ID 3405, SEQ ID 3406, SEQ ID 3407, SEQ ID 3408, SEQ ID 3409, SEQ ID 3410, SEQ ID 3411, SEQ ID 3412, SEQ ID 3413, SEQ ID 3414, SEQ ID 3415, SEQ ID 3416, SEQ ID 3417, SEQ ID 3418, SEQ ID 3419, SEQ ID 3420, SEQ ID 3421, SEQ ID 3422, SEQ ID 3423, SEQ ID 3424, SEQ ID 3425, SEQ ID 3426, SEQ ID 3427, SEQ ID 3428, SEQ ID 3429, SEQ ID 3430, SEQ ID 3431, SEQ ID 3432, SEQ ID 3433, SEQ ID 3434, SEQ ID 3435, SEQ ID 3436, SEQ ID 3437, SEQ ID 3438, SEQ ID 3439, SEQ ID 3440, SEQ ID 3441, SEQ ID 3442, SEQ ID 3443, SEQ ID 3444, SEQ ID 3445, SEQ ID 3446, SEQ ID 3447, SEQ ID 3448, SEQ ID 3449, SEQ ID 3450, SEQ ID 3451, SEQ ID 3452, SEQ ID 3453, SEQ ID 3454, SEQ ID 3460, SEQ ID 3461, SEQ ID 3464, SEQ ID 3465, SEQ ID 3466, SEQ ID 3467, SEQ ID 3468, SEQ ID 3486, SEQ ID 3487, SEQ ID 3488, SEQ ID 3489, SEQ ID 3490, SEQ ID 3491, SEQ ID 3493, SEQ ID 3494, SEQ ID 3496, SEQ ID 3497, SEQ ID 3501, SEQ ID 3505, SEQ ID 3508, SEQ ID 3511, SEQ ID 3512, SEQ ID 3516, SEQ ID 3517, SEQ ID 3518, SEQ ID 3521, SEQ ID 3522, SEQ ID 3523, SEQ ID 3524, SEQ ID 3525, SEQ ID 3526, SEQ ID 3527, SEQ ID 3528, SEQ ID 3530, SEQ ID 3531, SEQ ID 3532, SEQ ID 3534, SEQ ID 3535, SEQ ID 3536, SEQ ID 3538, SEQ ID 3539, SEQ ID 3541, SEQ ID 3542, SEQ ID 3543, SEQ ID 3544, SEQ ID 3546, SEQ ID 3548, SEQ ID 3549, SEQ ID 3550, SEQ ID 3552, SEQ ID 3556, SEQ ID 3557, SEQ ID 3558, SEQ ID 3560, SEQ ID 3561, SEQ ID 3566, SEQ ID 3567, SEQ ID 3568, SEQ ID 3569, SEQ ID 3571, SEQ ID 3572, SEQ ID 3573, SEQ ID 3574, SEQ ID 3576, SEQ ID 3577, SEQ ID 3578, SEQ ID 3580, SEQ ID 3581, SEQ ID 3584, SEQ ID 3585, SEQ ID 3586, SEQ ID 3588, SEQ ID 3590, SEQ ID 3592, SEQ ID 3594, SEQ ID 3595, SEQ ID 3598, SEQ ID 3599, SEQ ID 3600, SEQ ID 3601, SEQ ID 3602, SEQ ID 3603, SEQ ID 3605, SEQ ID 3607, SEQ ID 3609, SEQ ID 3610, SEQ ID 3613, SEQ ID 3614, SEQ ID 3615, SEQ ID 3616, SEQ ID 3617, SEQ ID 3621, SEQ ID 3623, SEQ ID 3624, SEQ ID 3625, SEQ ID 3626, SEQ ID 3627, SEQ ID 3628, SEQ ID 3629, SEQ ID 3630, SEQ ID 3631, SEQ ID 3632, SEQ ID 3633, SEQ ID 3636, SEQ ID 3637, SEQ ID 3638, SEQ ID 3639, SEQ ID 3641, SEQ ID 3642, SEQ ID 3643, SEQ ID 3645, SEQ ID 3647, SEQ ID 3648, SEQ ID 3649, SEQ ID 3651, SEQ ID 3654, SEQ ID 3656, SEQ ID 3659, SEQ ID 3660, SEQ ID 3661, SEQ ID 3663, SEQ ID 3664, SEQ ID 3665, SEQ ID 3666, SEQ ID 3670, SEQ ID 3672, SEQ ID 3676, SEQ ID 3678, SEQ ID 3679, SEQ ID 3680, SEQ ID 3681, SEQ ID 3682, SEQ ID 3683, SEQ ID 3684, SEQ ID 3685, SEQ ID 3686, SEQ ID 3687, SEQ ID 3688, SEQ ID 3689, SEQ ID 3690, SEQ ID 3691, SEQ ID 3692, SEQ ID 3693, SEQ ID 3694, SEQ ID 3695, SEQ ID 3696, SEQ ID 3697, SEQ ID 3698, SEQ ID 3699, SEQ ID 3700, SEQ ID 3701, SEQ ID 3702, SEQ ID 3703, SEQ ID 3704, SEQ ID 3705, SEQ ID 3706, SEQ ID 3707, SEQ ID 3708, SEQ ID 3709, SEQ ID 3710, SEQ ID 3711, SEQ ID 3712, SEQ ID 3713, SEQ ID 3714, SEQ ID 3715, SEQ ID 3716, SEQ ID 3717, SEQ ID 3718, SEQ ID 3719, SEQ ID 3720, SEQ ID 3721, SEQ ID 3722, SEQ ID 3723, SEQ ID 3724, SEQ ID 3725, SEQ ID 3726, SEQ ID 3727, SEQ ID 3729, SEQ ID 3730, SEQ ID 3731, SEQ ID 3732, SEQ ID 3733, SEQ ID 3734, SEQ ID 3735, SEQ ID 3736, SEQ ID 3737, SEQ ID 3738, SEQ ID 3739, SEQ ID 3740, SEQ ID 3741, SEQ ID 3742, SEQ ID 3743, SEQ ID 3744, SEQ ID 3745, SEQ ID 3746, SEQ ID 3747, SEQ ID 3748, SEQ ID 3749, SEQ ID 3750, SEQ ID 3751, SEQ ID 3752, SEQ ID 3753, SEQ ID 3754, SEQ ID 3755, SEQ ID 3774, SEQ ID 3775, SEQ ID 3776, SEQ ID 3777, SEQ ID 3778, SEQ ID 3779, SEQ ID 3780, SEQ ID 3781, SEQ ID 3782, SEQ ID 3783, SEQ ID 3784, SEQ ID 3785, SEQ ID 3786, SEQ ID 3787, SEQ ID 3788, SEQ ID 3789, SEQ ID 3790, SEQ ID 3791, SEQ ID 3792, SEQ ID 3793, SEQ ID 3794, SEQ ID 3795, SEQ ID 3796, SEQ ID 3797, SEQ ID 3798, SEQ ID 3799, SEQ ID 3800, SEQ ID 3801, SEQ ID 3802, SEQ ID 3803, SEQ ID 3804, SEQ ID 3805, SEQ ID 3806, SEQ ID 3807, SEQ ID 3808, SEQ ID 3809, SEQ ID 3810, SEQ ID 3811, SEQ ID 3812, SEQ ID 3813, SEQ ID 3814, SEQ ID 3815, SEQ ID 3816, SEQ ID 3817, SEQ ID 3818, SEQ ID 3819, SEQ ID 3820, SEQ ID 3821, SEQ ID 3822, SEQ ID 3823, SEQ ID 3824, SEQ ID 3825, SEQ ID 3826, SEQ ID 3827, SEQ ID 3828, SEQ ID 3829, SEQ ID 3830, SEQ ID 3831, SEQ ID 3832, SEQ ID 3833, SEQ ID 3834, SEQ ID 3835, SEQ ID 3836, SEQ ID 3837, SEQ ID 3838, SEQ ID 3839, SEQ ID 3840, SEQ ID 3841, SEQ ID 3842, SEQ ID 3844, SEQ ID 3848, SEQ ID 3850, SEQ ID 3851, SEQ ID 3852, SEQ ID 3853, SEQ ID 3867, SEQ ID 3868, SEQ ID 3869, SEQ ID 3870, SEQ ID 3871, SEQ ID 3872, SEQ ID 3873, SEQ ID 3874, SEQ ID 3875, SEQ ID 3876, SEQ ID 3877, SEQ ID 3878, SEQ ID 3879, SEQ ID 3880, SEQ ID 3881, SEQ ID 3882, SEQ ID 3883, SEQ ID 3884, SEQ ID 3885, SEQ ID 3886, SEQ ID 3887, SEQ ID 3888, SEQ ID 3889, SEQ ID 3890, SEQ ID 3891, SEQ ID 3892, SEQ ID 3893, SEQ ID 3894, SEQ ID 3895, SEQ ID 3896, SEQ ID 3897, SEQ ID 3898, SEQ ID 3899, SEQ ID 3900, SEQ ID 3901, SEQ ID 3902, SEQ ID 3903, SEQ ID 3904, SEQ ID 3905, SEQ ID 3906, SEQ ID 3907, SEQ ID 3908, SEQ ID 3909, SEQ ID 3910, SEQ ID 3911, SEQ ID 3912, SEQ ID 3913, SEQ ID 3914, SEQ ID 3915, SEQ ID 3916, SEQ ID 3917, SEQ ID 3918, SEQ ID 3919, SEQ ID 3920, SEQ ID 3921, SEQ ID 3922, SEQ ID 3923, SEQ ID 3924, SEQ ID 3925, SEQ ID 3926, SEQ ID 3927, SEQ ID 3928, SEQ ID 3929, SEQ ID 3930, SEQ ID 3931, SEQ ID 3932, SEQ ID 3933, SEQ ID 3934, SEQ ID 3935, SEQ ID 3936, SEQ ID 3937, SEQ ID 3938, SEQ ID 3939, SEQ ID 3940, SEQ ID 3941, SEQ ID 3942, SEQ ID 3943, SEQ ID 3944, SEQ ID 3945, SEQ ID 3946, SEQ ID 3947, and SEQ ID 3948, or at least 8, 9, 10, 11, 12, 13, 14, 15 or 16 contiguous nucleotides thereof.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 8 contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 9 contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 10 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 11 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 12 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 13 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 14 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 15 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments the contiguous nucleotide sequence is complementary, such as fully complementary, to at least 16 contiguous nucleotides contiguous nucleotides of any of the target sequences recited herein.

In some embodiments, the antisense oligonucleotide progranulin agonist is or comprises an antisense oligonucleotide mixmer or totalmer. In some embodiments, the contiguous nucleotide sequence is a mixmer or a totalmer.

In some embodiments, the antisense oligonucleotide progranulin agonist or contiguous nucleotide sequence thereof is 10-20 nucleotides in length.

In some embodiments, the antisense oligonucleotide progranulin agonist is selected from the group consisting of SEQ ID NOs 3-342.

In some embodiments, the antisense oligonucleotide progranulin agonist is selected from the group consisting of SEQ ID NOs 693-2039.

In some embodiments, the antisense oligonucleotide progranulin agonist is selected from the group consisting of SEQ ID 693, SEQ ID 694, SEQ ID 696, SEQ ID 700, SEQ ID 701, SEQ ID 703, SEQ ID 706, SEQ ID 707, SEQ ID 708, SEQ ID 709, SEQ ID 710, SEQ ID 711, SEQ ID 712, SEQ ID 713, SEQ ID 714, SEQ ID 717, SEQ ID 718, SEQ ID 719, SEQ ID 720, SEQ ID 721, SEQ ID 722, SEQ ID 723, SEQ ID 724, SEQ ID 725, SEQ ID 726, SEQ ID 727, SEQ ID 728, SEQ ID 729, SEQ ID 730, SEQ ID 731, SEQ ID 732, SEQ ID 733, SEQ ID 734, SEQ ID 736, SEQ ID 737, SEQ ID 738, SEQ ID 739, SEQ ID 740, SEQ ID 741, SEQ ID 742, SEQ ID 743, SEQ ID 744, SEQ ID 745, SEQ ID 746, SEQ ID 747, SEQ ID 748, SEQ ID 749, SEQ ID 750, SEQ ID 751, SEQ ID 752, SEQ ID 753, SEQ ID 756, SEQ ID 758, SEQ ID 759, SEQ ID 760, SEQ ID 761, SEQ ID 762, SEQ ID 764, SEQ ID 765, SEQ ID 766, SEQ ID 767, SEQ ID 768, SEQ ID 769, SEQ ID 770, SEQ ID 771, SEQ ID 772, SEQ ID 773, SEQ ID 775, SEQ ID 776, SEQ ID 777, SEQ ID 778, SEQ ID 779, SEQ ID 780, SEQ ID 782, SEQ ID 783, SEQ ID 785, SEQ ID 786, SEQ ID 787, SEQ ID 788, SEQ ID 790, SEQ ID 791, SEQ ID 793, SEQ ID 796, SEQ ID 797, SEQ ID 798, SEQ ID 799, SEQ ID 800, SEQ ID 801, SEQ ID 802, SEQ ID 803, SEQ ID 804, SEQ ID 805, SEQ ID 806, SEQ ID 807, SEQ ID 808, SEQ ID 809, SEQ ID 810, SEQ ID 811, SEQ ID 812, SEQ ID 813, SEQ ID 814, SEQ ID 815, SEQ ID 816, SEQ ID 817, SEQ ID 818, SEQ ID 819, SEQ ID 820, SEQ ID 821, SEQ ID 822, SEQ ID 823, SEQ ID 824, SEQ ID 825, SEQ ID 826, SEQ ID 827, SEQ ID 828, SEQ ID 829, SEQ ID 830, SEQ ID 831, SEQ ID 832, SEQ ID 833, SEQ ID 834, SEQ ID 835, SEQ ID 836, SEQ ID 837, SEQ ID 838, SEQ ID 839, SEQ ID 840, SEQ ID 841, SEQ ID 842, SEQ ID 843, SEQ ID 844, SEQ ID 845, SEQ ID 846, SEQ ID 847, SEQ ID 848, SEQ ID 849, SEQ ID 850, SEQ ID 851, SEQ ID 853, SEQ ID 854, SEQ ID 855, SEQ ID 856, SEQ ID 857, SEQ ID 859, SEQ ID 861, SEQ ID 862, SEQ ID 863, SEQ ID 864, SEQ ID 865, SEQ ID 866, SEQ ID 867, SEQ ID 868, SEQ ID 869, SEQ ID 870, SEQ ID 871, SEQ ID 873, SEQ ID 874, SEQ ID 875, SEQ ID 876, SEQ ID 877, SEQ ID 878, SEQ ID 879, SEQ ID 880, SEQ ID 881, SEQ ID 882, SEQ ID 883, SEQ ID 884, SEQ ID 885, SEQ ID 886, SEQ ID 887, SEQ ID 888, SEQ ID 890, SEQ ID 891, SEQ ID 892, SEQ ID 893, SEQ ID 894, SEQ ID 895, SEQ ID 896, SEQ ID 897, SEQ ID 898, SEQ ID 899, SEQ ID 900, SEQ ID 903, SEQ ID 905, SEQ ID 906, SEQ ID 907, SEQ ID 908, SEQ ID 909, SEQ ID 910, SEQ ID 912, SEQ ID 913, SEQ ID 914, SEQ ID 916, SEQ ID 918, SEQ ID 919, SEQ ID 921, SEQ ID 922, SEQ ID 923, SEQ ID 925, SEQ ID 926, SEQ ID 927, SEQ ID 928, SEQ ID 929, SEQ ID 932, SEQ ID 933, SEQ ID 934, SEQ ID 935, SEQ ID 937, SEQ ID 938, SEQ ID 939, SEQ ID 944, SEQ ID 945, SEQ ID 946, SEQ ID 947, SEQ ID 948, SEQ ID 949, SEQ ID 950, SEQ ID 951, SEQ ID 952, SEQ ID 953, SEQ ID 954, SEQ ID 955, SEQ ID 956, SEQ ID 957, SEQ ID 958, SEQ ID 960, SEQ ID 961, SEQ ID 962, SEQ ID 963, SEQ ID 964, SEQ ID 965, SEQ ID 966, SEQ ID 967, SEQ ID 968, SEQ ID 969, SEQ ID 970, SEQ ID 971, SEQ ID 973, SEQ ID 974, SEQ ID 975, SEQ ID 976, SEQ ID 978, SEQ ID 982, SEQ ID 985, SEQ ID 986, SEQ ID 987, SEQ ID 991, SEQ ID 994, SEQ ID 995, SEQ ID 996, SEQ ID 997, SEQ ID 998, SEQ ID 999, SEQ ID 1000, SEQ ID 1001, SEQ ID 1002, SEQ ID 1003, SEQ ID 1004, SEQ ID 1005, SEQ ID 1006, SEQ ID 1007, SEQ ID 1008, SEQ ID 1009, SEQ ID 1010, SEQ ID 1011, SEQ ID 1012, SEQ ID 1013, SEQ ID 1014, SEQ ID 1015, SEQ ID 1016, SEQ ID 1017, SEQ ID 1018, SEQ ID 1019, SEQ ID 1020, SEQ ID 1021, SEQ ID 1022, SEQ ID 1023, SEQ ID 1024, SEQ ID 1025, SEQ ID 1026, SEQ ID 1027, SEQ ID 1028, SEQ ID 1030, SEQ ID 1031, SEQ ID 1032, SEQ ID 1033, SEQ ID 1034, SEQ ID 1035, SEQ ID 1036, SEQ ID 1037, SEQ ID 1038, SEQ ID 1039, SEQ ID 1040, SEQ ID 1041, SEQ ID 1042, SEQ ID 1043, SEQ ID 1044, SEQ ID 1045, SEQ ID 1046, SEQ ID 1047, SEQ ID 1048, SEQ ID 1049, SEQ ID 1050, SEQ ID 1051, SEQ ID 1052, SEQ ID 1053, SEQ ID 1054, SEQ ID 1055, SEQ ID 1056, SEQ ID 1057, SEQ ID 1058, SEQ ID 1059, SEQ ID 1060, SEQ ID 1061, SEQ ID 1062, SEQ ID 1063, SEQ ID 1065, SEQ ID 1066, SEQ ID 1067, SEQ ID 1068, SEQ ID 1069, SEQ ID 1070, SEQ ID 1071, SEQ ID 1072, SEQ ID 1073, SEQ ID 1074, SEQ ID 1075, SEQ ID 1076, SEQ ID 1077, SEQ ID 1078, SEQ ID 1079, SEQ ID 1080, SEQ ID 1081, SEQ ID 1082, SEQ ID 1083, SEQ ID 1084, SEQ ID 1085, SEQ ID 1086, SEQ ID 1087, SEQ ID 1088, SEQ ID 1089, SEQ ID 1090, SEQ ID 1091, SEQ ID 1092, SEQ ID 1093, SEQ ID 1094, SEQ ID 1095, SEQ ID 1098, SEQ ID 1099, SEQ ID 1100, SEQ ID 1101, SEQ ID 1102, SEQ ID 1105, SEQ ID 1106, SEQ ID 1107, SEQ ID 1108, SEQ ID 1109, SEQ ID 1110, SEQ ID 1111, SEQ ID 1112, SEQ ID 1113, SEQ ID 1114, SEQ ID 1115, SEQ ID 1116, SEQ ID 1117, SEQ ID 1118, SEQ ID 1119, SEQ ID 1120, SEQ ID 1121, SEQ ID 1122, SEQ ID 1123, SEQ ID 1124, SEQ ID 1125, SEQ ID 1126, SEQ ID 1127, SEQ ID 1128, SEQ ID 1129, SEQ ID 1130, SEQ ID 1131, SEQ ID 1132, SEQ ID 1133, SEQ ID 1134, SEQ ID 1135, SEQ ID 1136, SEQ ID 1137, SEQ ID 1138, SEQ ID 1139, SEQ ID 1140, SEQ ID 1141, SEQ ID 1142, SEQ ID 1143, SEQ ID 1144, SEQ ID 1145, SEQ ID 1146, SEQ ID 1147, SEQ ID 1187, SEQ ID 1188, SEQ ID 1189, SEQ ID 1190, SEQ ID 1191, SEQ ID 1192, SEQ ID 1193, SEQ ID 1194, SEQ ID 1195, SEQ ID 1196, SEQ ID 1197, SEQ ID 1198, SEQ ID 1199, SEQ ID 1200, SEQ ID 1201, SEQ ID 1202, SEQ ID 1203, SEQ ID 1204, SEQ ID 1205, SEQ ID 1206, SEQ ID 1207, SEQ ID 1208, SEQ ID 1209, SEQ ID 1210, SEQ ID 1211, SEQ ID 1212, SEQ ID 1213, SEQ ID 1214, SEQ ID 1215, SEQ ID 1216, SEQ ID 1217, SEQ ID 1219, SEQ ID 1220, SEQ ID 1221, SEQ ID 1222, SEQ ID 1223, SEQ ID 1224, SEQ ID 1225, SEQ ID 1226, SEQ ID 1227, SEQ ID 1230, SEQ ID 1231, SEQ ID 1232, SEQ ID 1233, SEQ ID 1234, SEQ ID 1235, SEQ ID 1236, SEQ ID 1237, SEQ ID 1238, SEQ ID 1239, SEQ ID 1240, SEQ ID 1241, SEQ ID 1242, SEQ ID 1243, SEQ ID 1244, SEQ ID 1245, SEQ ID 1246, SEQ ID 1247, SEQ ID 1248, SEQ ID 1250, SEQ ID 1251, SEQ ID 1252, SEQ ID 1253, SEQ ID 1254, SEQ ID 1255, SEQ ID 1256, SEQ ID 1257, SEQ ID 1258, SEQ ID 1259, SEQ ID 1260, SEQ ID 1261, SEQ ID 1262, SEQ ID 1263, SEQ ID 1264, SEQ ID 1265, SEQ ID 1266, SEQ ID 1267, SEQ ID 1268, SEQ ID 1269, SEQ ID 1270, SEQ ID 1271, SEQ ID 1272, SEQ ID 1273, SEQ ID 1274, SEQ ID 1275, SEQ ID 1276, SEQ ID 1277, SEQ ID 1278, SEQ ID 1279, SEQ ID 1280, SEQ ID 1281, SEQ ID 1282, SEQ ID 1283, SEQ ID 1284, SEQ ID 1285, SEQ ID 1286, SEQ ID 1287, SEQ ID 1288, SEQ ID 1289, SEQ ID 1290, SEQ ID 1291, SEQ ID 1292, SEQ ID 1293, SEQ ID 1294, SEQ ID 1295, SEQ ID 1296, SEQ ID 1297, SEQ ID 1298, SEQ ID 1299, SEQ ID 1300, SEQ ID 1301, SEQ ID 1302, SEQ ID 1303, SEQ ID 1304, SEQ ID 1306, SEQ ID 1307, SEQ ID 1308, SEQ ID 1309, SEQ ID 1310, SEQ ID 1311, SEQ ID 1312, SEQ ID 1313, SEQ ID 1314, SEQ ID 1315, SEQ ID 1316, SEQ ID 1317, SEQ ID 1318, SEQ ID 1319, SEQ ID 1320, SEQ ID 1321, SEQ ID 1322, SEQ ID 1323, SEQ ID 1325, SEQ ID 1326, SEQ ID 1327, SEQ ID 1328, SEQ ID 1329, SEQ ID 1330, SEQ ID 1332, SEQ ID 1333, SEQ ID 1335, SEQ ID 1336, SEQ ID 1337, SEQ ID 1338, SEQ ID 1339, SEQ ID 1341, SEQ ID 1342, SEQ ID 1343, SEQ ID 1344, SEQ ID 1345, SEQ ID 1346, SEQ ID 1347, SEQ ID 1348, SEQ ID 1349, SEQ ID 1350, SEQ ID 1351, SEQ ID 1352, SEQ ID 1353, SEQ ID 1354, SEQ ID 1355, SEQ ID 1356, SEQ ID 1357, SEQ ID 1425, SEQ ID 1426, SEQ ID 1427, SEQ ID 1428, SEQ ID 1429, SEQ ID 1430, SEQ ID 1431, SEQ ID 1432, SEQ ID 1433, SEQ ID 1434, SEQ ID 1435, SEQ ID 1436, SEQ ID 1437, SEQ ID 1438, SEQ ID 1440, SEQ ID 1441, SEQ ID 1442, SEQ ID 1443, SEQ ID 1444, SEQ ID 1445, SEQ ID 1446, SEQ ID 1447, SEQ ID 1448, SEQ ID 1449, SEQ ID 1450, SEQ ID 1451, SEQ ID 1452, SEQ ID 1453, SEQ ID 1454, SEQ ID 1455, SEQ ID 1456, SEQ ID 1457, SEQ ID 1458, SEQ ID 1459, SEQ ID 1460, SEQ ID 1461, SEQ ID 1462, SEQ ID 1463, SEQ ID 1464, SEQ ID 1465, SEQ ID 1466, SEQ ID 1467, SEQ ID 1469, SEQ ID 1470, SEQ ID 1471, SEQ ID 1472, SEQ ID 1474, SEQ ID 1475, SEQ ID 1476, SEQ ID 1477, SEQ ID 1478, SEQ ID 1479, SEQ ID 1480, SEQ ID 1481, SEQ ID 1482, SEQ ID 1484, SEQ ID 1485, SEQ ID 1487, SEQ ID 1488, SEQ ID 1489, SEQ ID 1491, SEQ ID 1492, SEQ ID 1493, SEQ ID 1494, SEQ ID 1495, SEQ ID 1496, SEQ ID 1497, SEQ ID 1498, SEQ ID 1499, SEQ ID 1500, SEQ ID 1501, SEQ ID 1502, SEQ ID 1503, SEQ ID 1504, SEQ ID 1505, SEQ ID 1506, SEQ ID 1507, SEQ ID 1508, SEQ ID 1509, SEQ ID 1510, SEQ ID 1511, SEQ ID 1512, SEQ ID 1513, SEQ ID 1514, SEQ ID 1515, SEQ ID 1516, SEQ ID 1517, SEQ ID 1518, SEQ ID 1519, SEQ ID 1520, SEQ ID 1521, SEQ ID 1522, SEQ ID 1523, SEQ ID 1524, SEQ ID 1525, SEQ ID 1526, SEQ ID 1527, SEQ ID 1528, SEQ ID 1529, SEQ ID 1530, SEQ ID 1531, SEQ ID 1532, SEQ ID 1533, SEQ ID 1534, SEQ ID 1535, SEQ ID 1536, SEQ ID 1537, SEQ ID 1538, SEQ ID 1539, SEQ ID 1540, SEQ ID 1541, SEQ ID 1542, SEQ ID 1543, SEQ ID 1544, SEQ ID 1545, SEQ ID 1546, SEQ ID 1547, SEQ ID 1548, SEQ ID 1549, SEQ ID 1550, SEQ ID 1551, SEQ ID 1552, SEQ ID 1553, SEQ ID 1554, SEQ ID 1555, SEQ ID 1556, SEQ ID 1557, SEQ ID 1558, SEQ ID 1559, SEQ ID 1560, SEQ ID 1561, SEQ ID 1562, SEQ ID 1563, SEQ ID 1564, SEQ ID 1565, SEQ ID 1566, SEQ ID 1567, SEQ ID 1568, SEQ ID 1569, SEQ ID 1570, SEQ ID 1571, SEQ ID 1572, SEQ ID 1573, SEQ ID 1574, SEQ ID 1575, SEQ ID 1576, SEQ ID 1577, SEQ ID 1578, SEQ ID 1579, SEQ ID 1580, SEQ ID 1581, SEQ ID 1582, SEQ ID 1583, SEQ ID 1584, SEQ ID 1585, SEQ ID 1586, SEQ ID 1587, SEQ ID 1588, SEQ ID 1589, SEQ ID 1590, SEQ ID 1591, SEQ ID 1592, SEQ ID 1593, SEQ ID 1594, SEQ ID 1595, SEQ ID 1596, SEQ ID 1597, SEQ ID 1598, SEQ ID 1599, SEQ ID 1600, SEQ ID 1601, SEQ ID 1602, SEQ ID 1603, SEQ ID 1604, SEQ ID 1605, SEQ ID 1606, SEQ ID 1607, SEQ ID 1608, SEQ ID 1609, SEQ ID 1610, SEQ ID 1611, SEQ ID 1612, SEQ ID 1613, SEQ ID 1614, SEQ ID 1615, SEQ ID 1616, SEQ ID 1617, SEQ ID 1618, SEQ ID 1620, SEQ ID 1621, SEQ ID 1622, SEQ ID 1623, SEQ ID 1624, SEQ ID 1625, SEQ ID 1626, SEQ ID 1627, SEQ ID 1628, SEQ ID 1629, SEQ ID 1630, SEQ ID 1631, SEQ ID 1632, SEQ ID 1633, SEQ ID 1634, SEQ ID 1635, SEQ ID 1636, SEQ ID 1637, SEQ ID 1638, SEQ ID 1639, SEQ ID 1640, SEQ ID 1641, SEQ ID 1642, SEQ ID 1643, SEQ ID 1644, SEQ ID 1645, SEQ ID 1647, SEQ ID 1648, SEQ ID 1649, SEQ ID 1650, SEQ ID 1651, SEQ ID 1652, SEQ ID 1654, SEQ ID 1656, SEQ ID 1657, SEQ ID 1658, SEQ ID 1659, SEQ ID 1660, SEQ ID 1661, SEQ ID 1663, SEQ ID 1664, SEQ ID 1665, SEQ ID 1666, SEQ ID 1667, SEQ ID 1668, SEQ ID 1669, SEQ ID 1670, SEQ ID 1671, SEQ ID 1672, SEQ ID 1673, SEQ ID 1674, SEQ ID 1675, SEQ ID 1676, SEQ ID 1677, SEQ ID 1678, SEQ ID 1679, SEQ ID 1680, SEQ ID 1681, SEQ ID 1682, SEQ ID 1683, SEQ ID 1684, SEQ ID 1685, SEQ ID 1686, SEQ ID 1687, SEQ ID 1688, SEQ ID 1689, SEQ ID 1690, SEQ ID 1692, SEQ ID 1693, SEQ ID 1694, SEQ ID 1695, SEQ ID 1696, SEQ ID 1697, SEQ ID 1698, SEQ ID 1699, SEQ ID 1701, SEQ ID 1703, SEQ ID 1704, SEQ ID 1705, SEQ ID 1706, SEQ ID 1707, SEQ ID 1708, SEQ ID 1709, SEQ ID 1710, SEQ ID 1711, SEQ ID 1712, SEQ ID 1714, SEQ ID 1715, SEQ ID 1716, SEQ ID 1717, SEQ ID 1718, SEQ ID 1719, SEQ ID 1720, SEQ ID 1721, SEQ ID 1722, SEQ ID 1723, SEQ ID 1724, SEQ ID 1725, SEQ ID 1726, SEQ ID 1727, SEQ ID 1728, SEQ ID 1729, SEQ ID 1730, SEQ ID 1731, SEQ ID 1732, SEQ ID 1733, SEQ ID 1734, SEQ ID 1735, SEQ ID 1736, SEQ ID 1737, SEQ ID 1738, SEQ ID 1739, SEQ ID 1740, SEQ ID 1741, SEQ ID 1742, SEQ ID 1743, SEQ ID 1762, SEQ ID 1763, SEQ ID 1764, SEQ ID 1765, SEQ ID 1766, SEQ ID 1767, SEQ ID 1768, SEQ ID 1769, SEQ ID 1770, SEQ ID 1771, SEQ ID 1772, SEQ ID 1773, SEQ ID 1774, SEQ ID 1775, SEQ ID 1776, SEQ ID 1777, SEQ ID 1778, SEQ ID 1779, SEQ ID 1780, SEQ ID 1781, SEQ ID 1782, SEQ ID 1783, SEQ ID 1784, SEQ ID 1785, SEQ ID 1786, SEQ ID 1787, SEQ ID 1788, SEQ ID 1789, SEQ ID 1790, SEQ ID 1791, SEQ ID 1792, SEQ ID 1793, SEQ ID 1794, SEQ ID 1795, SEQ ID 1796, SEQ ID 1797, SEQ ID 1798, SEQ ID 1799, SEQ ID 1800, SEQ ID 1801, SEQ ID 1802, SEQ ID 1803, SEQ ID 1804, SEQ ID 1805, SEQ ID 1806, SEQ ID 1807, SEQ ID 1808, SEQ ID 1809, SEQ ID 1810, SEQ ID 1811, SEQ ID 1812, SEQ ID 1813, SEQ ID 1814, SEQ ID 1815, SEQ ID 1816, SEQ ID 1817, SEQ ID 1818, SEQ ID 1819, SEQ ID 1820, SEQ ID 1821, SEQ ID 1822, SEQ ID 1823, SEQ ID 1824, SEQ ID 1825, SEQ ID 1826, SEQ ID 1832, SEQ ID 1833, SEQ ID 1836, SEQ ID 1837, SEQ ID 1838, SEQ ID 1839, SEQ ID 1840, SEQ ID 1858, SEQ ID 1859, SEQ ID 1860, SEQ ID 1861, SEQ ID 1862, SEQ ID 1863, SEQ ID 1865, SEQ ID 1866, SEQ ID 1868, SEQ ID 1869, SEQ ID 1873, SEQ ID 1877, SEQ ID 1880, SEQ ID 1883, SEQ ID 1884, SEQ ID 1888, SEQ ID 1889, SEQ ID 1890, SEQ ID 1893, SEQ ID 1894, SEQ ID 1895, SEQ ID 1896, SEQ ID 1897, SEQ ID 1898, SEQ ID 1899, SEQ ID 1900, SEQ ID 1902, SEQ ID 1903, SEQ ID 1904, SEQ ID 1906, SEQ ID 1907, SEQ ID 1908, SEQ ID 1910, SEQ ID 1911, SEQ ID 1913, SEQ ID 1914, SEQ ID 1915, SEQ ID 1916, SEQ ID 1918, SEQ ID 1920, SEQ ID 1921, SEQ ID 1922, SEQ ID 1924, SEQ ID 1928, SEQ ID 1929, SEQ ID 1930, SEQ ID 1932, SEQ ID 1933, SEQ ID 1938, SEQ ID 1939, SEQ ID 1940, SEQ ID 1941, SEQ ID 1943, SEQ ID 1944, SEQ ID 1945, SEQ ID 1946, SEQ ID 1948, SEQ ID 1949, SEQ ID 1950, SEQ ID 1952, SEQ ID 1953, SEQ ID 1956, SEQ ID 1957, SEQ ID 1958, SEQ ID 1960, SEQ ID 1962, SEQ ID 1964, SEQ ID 1966, SEQ ID 1967, SEQ ID 1970, SEQ ID 1971, SEQ ID 1972, SEQ ID 1973, SEQ ID 1974, SEQ ID 1975, SEQ ID 1977, SEQ ID 1979, SEQ ID 1981, SEQ ID 1982, SEQ ID 1985, SEQ ID 1986, SEQ ID 1987, SEQ ID 1988, SEQ ID 1989, SEQ ID 1993, SEQ ID 1995, SEQ ID 1996, SEQ ID 1997, SEQ ID 1998, SEQ ID 1999, SEQ ID 2000, SEQ ID 2001, SEQ ID 2002, SEQ ID 2003, SEQ ID 2004, SEQ ID 2005, SEQ ID 2008, SEQ ID 2009, SEQ ID 2010, SEQ ID 2011, SEQ ID 2013, SEQ ID 2014, SEQ ID 2015, SEQ ID 2017, SEQ ID 2019, SEQ ID 2020, SEQ ID 2021, SEQ ID 2023, SEQ ID 2026, SEQ ID 2028, SEQ ID 2031, SEQ ID 2032, SEQ ID 2033, SEQ ID 2035, SEQ ID 2036, SEQ ID 2037, SEQ ID 2038, SEQ ID 2042, SEQ ID 2044, SEQ ID 2048, SEQ ID 2050, SEQ ID 2051, SEQ ID 2052, SEQ ID 2053, SEQ ID 2054, SEQ ID 2055, SEQ ID 2056, SEQ ID 2057, SEQ ID 2058, SEQ ID 2059, SEQ ID 2060, SEQ ID 2061, SEQ ID 2062, SEQ ID 2063, SEQ ID 2064, SEQ ID 2065, SEQ ID 2066, SEQ ID 2067, SEQ ID 2068, SEQ ID 2069, SEQ ID 2070, SEQ ID 2071, SEQ ID 2072, SEQ ID 2073, SEQ ID 2074, SEQ ID 2075, SEQ ID 2076, SEQ ID 2077, SEQ ID 2078, SEQ ID 2079, SEQ ID 2080, SEQ ID 2081, SEQ ID 2082, SEQ ID 2083, SEQ ID 2084, SEQ ID 2085, SEQ ID 2086, SEQ ID 2087, SEQ ID 2088, SEQ ID 2089, SEQ ID 2090, SEQ ID 2091, SEQ ID 2092, SEQ ID 2093, SEQ ID 2094, SEQ ID 2095, SEQ ID 2096, SEQ ID 2097, SEQ ID 2098, SEQ ID 2099, SEQ ID 2101, SEQ ID 2102, SEQ ID 2103, SEQ ID 2104, SEQ ID 2105, SEQ ID 2106, SEQ ID 2107, SEQ ID 2108, SEQ ID 2109, SEQ ID 2110, SEQ ID 2111, SEQ ID 2112, SEQ ID 2113, SEQ ID 2114, SEQ ID 2115, SEQ ID 2116, SEQ ID 2117, SEQ ID 2118, SEQ ID 2119, SEQ ID 2120, SEQ ID 2121, SEQ ID 2122, SEQ ID 2123, SEQ ID 2124, SEQ ID 2125, SEQ ID 2126, SEQ ID 2127, SEQ ID 2146, SEQ ID 2147, SEQ ID 2148, SEQ ID 2149, SEQ ID 2150, SEQ ID 2151, SEQ ID 2152, SEQ ID 2153, SEQ ID 2154, SEQ ID 2155, SEQ ID 2156, SEQ ID 2157, SEQ ID 2158, SEQ ID 2159, SEQ ID 2160, SEQ ID 2161, SEQ ID 2162, SEQ ID 2163, SEQ ID 2164, SEQ ID 2165, SEQ ID 2166, SEQ ID 2167, SEQ ID 2168, SEQ ID 2169, SEQ ID 2170, SEQ ID 2171, SEQ ID 2172, SEQ ID 2173, SEQ ID 2174, SEQ ID 2175, SEQ ID 2176, SEQ ID 2177, SEQ ID 2178, SEQ ID 2179, SEQ ID 2180, SEQ ID 2181, SEQ ID 2182, SEQ ID 2183, SEQ ID 2184, SEQ ID 2185, SEQ ID 2186, SEQ ID 2187, SEQ ID 2188, SEQ ID 2189, SEQ ID 2190, SEQ ID 2191, SEQ ID 2192, SEQ ID 2193, SEQ ID 2194, SEQ ID 2195, SEQ ID 2196, SEQ ID 2197, SEQ ID 2198, SEQ ID 2199, SEQ ID 2200, SEQ ID 2201, SEQ ID 2202, SEQ ID 2203, SEQ ID 2204, SEQ ID 2205, SEQ ID 2206, SEQ ID 2207, SEQ ID 2208, SEQ ID 2209, SEQ ID 2210, SEQ ID 2211, SEQ ID 2212, SEQ ID 2213, SEQ ID 2214, SEQ ID 2216, SEQ ID 2220, SEQ ID 2222, SEQ ID 2223, SEQ ID 2224, SEQ ID 2225, SEQ ID 2239, SEQ ID 2240, SEQ ID 2241, SEQ ID 2242, SEQ ID 2243, SEQ ID 2244, SEQ ID 2245, SEQ ID 2246, SEQ ID 2247, SEQ ID 2248, SEQ ID 2249, SEQ ID 2250, SEQ ID 2251, SEQ ID 2252, SEQ ID 2253, SEQ ID 2254, SEQ ID 2255, SEQ ID 2256, SEQ ID 2257, SEQ ID 2258, SEQ ID 2259, SEQ ID 2260, SEQ ID 2261, SEQ ID 2262, SEQ ID 2263, SEQ ID 2264, SEQ ID 2265, SEQ ID 2266, SEQ ID 2267, SEQ ID 2268, SEQ ID 2269, SEQ ID 2270, SEQ ID 2271, SEQ ID 2272, SEQ ID 2273, SEQ ID 2274, SEQ ID 2275, SEQ ID 2276, SEQ ID 2277, SEQ ID 2278, SEQ ID 2279, SEQ ID 2280, SEQ ID 2281, SEQ ID 2282, SEQ ID 2283, SEQ ID 2284, SEQ ID 2285, SEQ ID 2286, SEQ ID 2287, SEQ ID 2288, SEQ ID 2289, SEQ ID 2290, SEQ ID 2291, SEQ ID 2292, SEQ ID 2293, SEQ ID 2294, SEQ ID 2295, SEQ ID 2296, SEQ ID 2297, SEQ ID 2298, SEQ ID 2299, SEQ ID 2300, SEQ ID 2301, SEQ ID 2302, SEQ ID 2303, SEQ ID 2304, SEQ ID 2305, SEQ ID 2306, SEQ ID 2307, SEQ ID 2308, SEQ ID 2309, SEQ ID 2310, SEQ ID 2311, SEQ ID 2312, SEQ ID 2313, SEQ ID 2314, SEQ ID 2315, SEQ ID 2316, SEQ ID 2317, SEQ ID 2318, SEQ ID 2319, and SEQ ID 2320.

In some embodiments, the antisense oligonucleotide progranulin agonist is selected from the group consisting of SEQ ID 693, SEQ ID 707, SEQ ID 708, SEQ ID 709, SEQ ID 710, SEQ ID 711, SEQ ID 720, SEQ ID 721, SEQ ID 723, SEQ ID 724, SEQ ID 725, SEQ ID 726, SEQ ID 727, SEQ ID 730, SEQ ID 732, SEQ ID 736, SEQ ID 737, SEQ ID 738, SEQ ID 739, SEQ ID 741, SEQ ID 743, SEQ ID 745, SEQ ID 747, SEQ ID 758, SEQ ID 759, SEQ ID 760, SEQ ID 761, SEQ ID 766, SEQ ID 775, SEQ ID 798, SEQ ID 800, SEQ ID 801, SEQ ID 802, SEQ ID 803, SEQ ID 804, SEQ ID 807, SEQ ID 812, SEQ ID 813, SEQ ID 814, SEQ ID 816, SEQ ID 818, SEQ ID 819, SEQ ID 822, SEQ ID 823, SEQ ID 824, SEQ ID 825, SEQ ID 826, SEQ ID 827, SEQ ID 828, SEQ ID 830, SEQ ID 831, SEQ ID 833, SEQ ID 835, SEQ ID 836, SEQ ID 837, SEQ ID 838, SEQ ID 839, SEQ ID 840, SEQ ID 841, SEQ ID 842, SEQ ID 843, SEQ ID 844, SEQ ID 845, SEQ ID 846, SEQ ID 847, SEQ ID 848, SEQ ID 849, SEQ ID 850, SEQ ID 854, SEQ ID 855, SEQ ID 856, SEQ ID 857, SEQ ID 859, SEQ ID 861, SEQ ID 866, SEQ ID 867, SEQ ID 868, SEQ ID 869, SEQ ID 871, SEQ ID 873, SEQ ID 874, SEQ ID 876, SEQ ID 878, SEQ ID 879, SEQ ID 880, SEQ ID 881, SEQ ID 883, SEQ ID 885, SEQ ID 887, SEQ ID 888, SEQ ID 890, SEQ ID 891, SEQ ID 892, SEQ ID 893, SEQ ID 895, SEQ ID 897, SEQ ID 906, SEQ ID 909, SEQ ID 916, SEQ ID 918, SEQ ID 926, SEQ ID 927, SEQ ID 928, SEQ ID 932, SEQ ID 933, SEQ ID 934, SEQ ID 967, SEQ ID 998, SEQ ID 1000, SEQ ID 1001, SEQ ID 1002, SEQ ID 1003, SEQ ID 1005, SEQ ID 1010, SEQ ID 1011, SEQ ID 1012, SEQ ID 1021, SEQ ID 1023, SEQ ID 1024, SEQ ID 1027, SEQ ID 1030, SEQ ID 1037, SEQ ID 1038, SEQ ID 1039, SEQ ID 1041, SEQ ID 1042, SEQ ID 1048, SEQ ID 1049, SEQ ID 1050, SEQ ID 1051, SEQ ID 1054, SEQ ID 1058, SEQ ID 1060, SEQ ID 1061, SEQ ID 1063, SEQ ID 1066, SEQ ID 1070, SEQ ID 1071, SEQ ID 1072, SEQ ID 1073, SEQ ID 1075, SEQ ID 1078, SEQ ID 1081, SEQ ID 1083, SEQ ID 1084, SEQ ID 1085, SEQ ID 1086, SEQ ID 1091, SEQ ID 1092, SEQ ID 1093, SEQ ID 1109, SEQ ID 1111, SEQ ID 1112, SEQ ID 1113, SEQ ID 1114, SEQ ID 1115, SEQ ID 1116, SEQ ID 1117, SEQ ID 1118, SEQ ID 1119, SEQ ID 1120, SEQ ID 1121, SEQ ID 1122, SEQ ID 1123, SEQ ID 1124, SEQ ID 1125, SEQ ID 1126, SEQ ID 1127, SEQ ID 1128, SEQ ID 1129, SEQ ID 1130, SEQ ID 1132, SEQ ID 1135, SEQ ID 1136, SEQ ID 1137, SEQ ID 1138, SEQ ID 1139, SEQ ID 1140, SEQ ID 1141, SEQ ID 1142, SEQ ID 1143, SEQ ID 1144, SEQ ID 1146, SEQ ID 1188, SEQ ID 1189, SEQ ID 1190, SEQ ID 1191, SEQ ID 1192, SEQ ID 1196, SEQ ID 1200, SEQ ID 1201, SEQ ID 1202, SEQ ID 1203, SEQ ID 1204, SEQ ID 1205, SEQ ID 1206, SEQ ID 1207, SEQ ID 1208, SEQ ID 1209, SEQ ID 1223, SEQ ID 1224, SEQ ID 1238, SEQ ID 1243, SEQ ID 1244, SEQ ID 1258, SEQ ID 1259, SEQ ID 1262, SEQ ID 1263, SEQ ID 1264, SEQ ID 1267, SEQ ID 1268, SEQ ID 1271, SEQ ID 1276, SEQ ID 1282, SEQ ID 1283, SEQ ID 1284, SEQ ID 1285, SEQ ID 1286, SEQ ID 1288, SEQ ID 1290, SEQ ID 1291, SEQ ID 1292, SEQ ID 1294, SEQ ID 1297, SEQ ID 1298, SEQ ID 1304, SEQ ID 1311, SEQ ID 1313, SEQ ID 1314, SEQ ID 1315, SEQ ID 1344, SEQ ID 1345, SEQ ID 1346, SEQ ID 1347, SEQ ID 1348, SEQ ID 1349, SEQ ID 1352, SEQ ID 1355, SEQ ID 1357, SEQ ID 1425, SEQ ID 1426, SEQ ID 1427, SEQ ID 1428, SEQ ID 1430, SEQ ID 1431, SEQ ID 1432, SEQ ID 1433, SEQ ID 1434, SEQ ID 1435, SEQ ID 1436, SEQ ID 1437, SEQ ID 1438, SEQ ID 1440, SEQ ID 1441, SEQ ID 1442, SEQ ID 1443, SEQ ID 1444, SEQ ID 1445, SEQ ID 1446, SEQ ID 1447, SEQ ID 1448, SEQ ID 1449, SEQ ID 1450, SEQ ID 1451, SEQ ID 1454, SEQ ID 1455, SEQ ID 1456, SEQ ID 1457, SEQ ID 1460, SEQ ID 1461, SEQ ID 1462, SEQ ID 1463, SEQ ID 1464, SEQ ID 1467, SEQ ID 1469, SEQ ID 1474, SEQ ID 1478, SEQ ID 1480, SEQ ID 1482, SEQ ID 1488, SEQ ID 1492, SEQ ID 1493, SEQ ID 1497, SEQ ID 1498, SEQ ID 1505, SEQ ID 1506, SEQ ID 1507, SEQ ID 1509, SEQ ID 1510, SEQ ID 1512, SEQ ID 1513, SEQ ID 1514, SEQ ID 1515, SEQ ID 1517, SEQ ID 1520, SEQ ID 1524, SEQ ID 1525, SEQ ID 1528, SEQ ID 1529, SEQ ID 1530, SEQ ID 1531, SEQ ID 1532, SEQ ID 1533, SEQ ID 1534, SEQ ID 1535, SEQ ID 1536, SEQ ID 1537, SEQ ID 1538, SEQ ID 1539, SEQ ID 1540, SEQ ID 1541, SEQ ID 1542, SEQ ID 1544, SEQ ID 1545, SEQ ID 1546, SEQ ID 1547, SEQ ID 1548, SEQ ID 1549, SEQ ID 1550, SEQ ID 1551, SEQ ID 1552, SEQ ID 1553, SEQ ID 1554, SEQ ID 1555, SEQ ID 1556, SEQ ID 1558, SEQ ID 1560, SEQ ID 1563, SEQ ID 1565, SEQ ID 1568, SEQ ID 1569, SEQ ID 1575, SEQ ID 1577, SEQ ID 1578, SEQ ID 1579, SEQ ID 1582, SEQ ID 1583, SEQ ID 1584, SEQ ID 1585, SEQ ID 1586, SEQ ID 1587, SEQ ID 1588, SEQ ID 1589, SEQ ID 1590, SEQ ID 1591, SEQ ID 1593, SEQ ID 1594, SEQ ID 1595, SEQ ID 1596, SEQ ID 1599, SEQ ID 1608, SEQ ID 1609, SEQ ID 1610, SEQ ID 1611, SEQ ID 1612, SEQ ID 1613, SEQ ID 1614, SEQ ID 1615, SEQ ID 1616, SEQ ID 1617, SEQ ID 1618, SEQ ID 1620, SEQ ID 1621, SEQ ID 1622, SEQ ID 1623, SEQ ID 1624, SEQ ID 1626, SEQ ID 1630, SEQ ID 1631, SEQ ID 1633, SEQ ID 1635, SEQ ID 1637, SEQ ID 1638, SEQ ID 1639, SEQ ID 1643, SEQ ID 1644, SEQ ID 1645, SEQ ID 1648, SEQ ID 1649, SEQ ID 1651, SEQ ID 1658, SEQ ID 1667, SEQ ID 1669, SEQ ID 1677, SEQ ID 1679, SEQ ID 1681, SEQ ID 1684, SEQ ID 1685, SEQ ID 1686, SEQ ID 1688, SEQ ID 1689, SEQ ID 1690, SEQ ID 1692, SEQ ID 1704, SEQ ID 1707, SEQ ID 1708, SEQ ID 1709, SEQ ID 1710, SEQ ID 1711, SEQ ID 1712, SEQ ID 1714, SEQ ID 1715, SEQ ID 1717, SEQ ID 1718, SEQ ID 1719, SEQ ID 1720, SEQ ID 1721, SEQ ID 1722, SEQ ID 1723, SEQ ID 1724, SEQ ID 1725, SEQ ID 1726, SEQ ID 1727, SEQ ID 1728, SEQ ID 1731, SEQ ID 1732, SEQ ID 1733, SEQ ID 1734, SEQ ID 1735, SEQ ID 1736, SEQ ID 1737, SEQ ID 1738, SEQ ID 1741, SEQ ID 1742, SEQ ID 1762, SEQ ID 1764, SEQ ID 1765, SEQ ID 1766, SEQ ID 1767, SEQ ID 1768, SEQ ID 1769, SEQ ID 1770, SEQ ID 1771, SEQ ID 1773, SEQ ID 1775, SEQ ID 1776, SEQ ID 1779, SEQ ID 1780, SEQ ID 1781, SEQ ID 1782, SEQ ID 1783, SEQ ID 1784, SEQ ID 1785, SEQ ID 1786, SEQ ID 1787, SEQ ID 1789, SEQ ID 1791, SEQ ID 1792, SEQ ID 1794, SEQ ID 1795, SEQ ID 1796, SEQ ID 1800, SEQ ID 1801, SEQ ID 1802, SEQ ID 1804, SEQ ID 1805, SEQ ID 1806, SEQ ID 1807, SEQ ID 1808, SEQ ID 1809, SEQ ID 1811, SEQ ID 1812, SEQ ID 1813, SEQ ID 1814, SEQ ID 1815, SEQ ID 1816, SEQ ID 1817, SEQ ID 1818, SEQ ID 1819, SEQ ID 1820, SEQ ID 1821, SEQ ID 1822, SEQ ID 1823, SEQ ID 1824, SEQ ID 1832, SEQ ID 1833, SEQ ID 1838, SEQ ID 1839, SEQ ID 1840, SEQ ID 1862, SEQ ID 1866, SEQ ID 1868, SEQ ID 1873, SEQ ID 1877, SEQ ID 1883, SEQ ID 1884, SEQ ID 1888, SEQ ID 1889, SEQ ID 1893, SEQ ID 1894, SEQ ID 1928, SEQ ID 1929, SEQ ID 1933, SEQ ID 1938, SEQ ID 1939, SEQ ID 1940, SEQ ID 1941, SEQ ID 1943, SEQ ID 1944, SEQ ID 1948, SEQ ID 1950, SEQ ID 1952, SEQ ID 1956, SEQ ID 1966, SEQ ID 1985, SEQ ID 1986, SEQ ID 1996, SEQ ID 1997, SEQ ID 1998, SEQ ID 1999, SEQ ID 2000, SEQ ID 2005, SEQ ID 2013, SEQ ID 2015, SEQ ID 2020, SEQ ID 2023, SEQ ID 2026, SEQ ID 2028, SEQ ID 2031, SEQ ID 2032, SEQ ID 2033, SEQ ID 2042, SEQ ID 2048, SEQ ID 2052, SEQ ID 2053, SEQ ID 2055, SEQ ID 2056, SEQ ID 2057, SEQ ID 2058, SEQ ID 2059, SEQ ID 2060, SEQ ID 2061, SEQ ID 2063, SEQ ID 2065, SEQ ID 2066, SEQ ID 2067, SEQ ID 2068, SEQ ID 2070, SEQ ID 2072, SEQ ID 2073, SEQ ID 2075, SEQ ID 2076, SEQ ID 2079, SEQ ID 2080, SEQ ID 2081, SEQ ID 2082, SEQ ID 2083, SEQ ID 2084, SEQ ID 2085, SEQ ID 2086, SEQ ID 2087, SEQ ID 2088, SEQ ID 2089, SEQ ID 2090, SEQ ID 2091, SEQ ID 2092, SEQ ID 2093, SEQ ID 2094, SEQ ID 2095, SEQ ID 2097, SEQ ID 2116, SEQ ID 2119, SEQ ID 2120, SEQ ID 2121, SEQ ID 2122, SEQ ID 2123, SEQ ID 2124, SEQ ID 2125, SEQ ID 2126, SEQ ID 2127, SEQ ID 2146, SEQ ID 2147, SEQ ID 2148, SEQ ID 2158, SEQ ID 2160, SEQ ID 2162, SEQ ID 2163, SEQ ID 2165, SEQ ID 2166, SEQ ID 2167, SEQ ID 2168, SEQ ID 2169, SEQ ID 2170, SEQ ID 2171, SEQ ID 2172, SEQ ID 2173, SEQ ID 2174, SEQ ID 2175, SEQ ID 2176, SEQ ID 2177, SEQ ID 2181, SEQ ID 2182, SEQ ID 2183, SEQ ID 2184, SEQ ID 2185, SEQ ID 2186, SEQ ID 2187, SEQ ID 2193, SEQ ID 2194, SEQ ID 2195, SEQ ID 2196, SEQ ID 2197, SEQ ID 2198, SEQ ID 2199, SEQ ID 2200, SEQ ID 2202, SEQ ID 2203, SEQ ID 2204, SEQ ID 2206, SEQ ID 2208, SEQ ID 2209, SEQ ID 2210, SEQ ID 2211, SEQ ID 2212, SEQ ID 2213, SEQ ID 2214, SEQ ID 2216, SEQ ID 2222, SEQ ID 2224, SEQ ID 2239, SEQ ID 2240, SEQ ID 2242, SEQ ID 2243, SEQ ID 2244, SEQ ID 2245, SEQ ID 2246, SEQ ID 2247, SEQ ID 2248, SEQ ID 2251, SEQ ID 2252, SEQ ID 2253, SEQ ID 2254, SEQ ID 2255, SEQ ID 2256, SEQ ID 2257, SEQ ID 2258, SEQ ID 2259, SEQ ID 2260, SEQ ID 2261, SEQ ID 2262, SEQ ID 2263, SEQ ID 2264, SEQ ID 2265, SEQ ID 2266, SEQ ID 2267, SEQ ID 2268, SEQ ID 2269, SEQ ID 2280, SEQ ID 2281, SEQ ID 2282, SEQ ID 2283, SEQ ID 2284, SEQ ID 2285, SEQ ID 2294, SEQ ID 2295, SEQ ID 2302, SEQ ID 2307, SEQ ID 2308, SEQ ID 2309, SEQ ID 2310, SEQ ID 2311, SEQ ID 2312, SEQ ID 2316, SEQ ID 2317, SEQ ID 2318, SEQ ID 2319, and SEQ ID 2320.

The invention provides for a conjugate comprising the antisense oligonucleotide progranulin agonist according to the invention, and at least one conjugate moiety covalently attached to said antisense oligonucleotide progranulin agonist.

The invention provides an antisense oligonucleotide progranulin agonist covalently attached to at least one conjugate moiety.

The invention provides for a pharmaceutically acceptable salt of the antisense oligonucleotide progranulin agonist according to the invention, or the conjugate according to the invention.

The invention provides for an antisense oligonucleotide progranulin agonist according to the invention wherein the antisense oligonucleotide progranulin agonist is in the form of a pharmaceutically acceptable salt. In some embodiments the pharmaceutically acceptable salt may be a sodium salt or a potassium salt.

The invention provides for a pharmaceutically acceptable sodium salt of the antisense oligonucleotide progranulin agonist according to the invention, or the conjugate according to the invention.

The invention provides for a pharmaceutically acceptable potassium salt of the antisense oligonucleotide progranulin agonist according to the invention, or the conjugate according to the invention.

The invention provides for a pharmaceutical composition comprising the antisense oligonucleotide progranulin agonist of the invention, or the conjugate of the invention, and a pharmaceutically acceptable diluent, solvent, carrier, salt and/or adjuvant.

The invention provides for a pharmaceutical composition according to the invention, wherein the pharmaceutical composition comprises the antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the pharmaceutically acceptable salt of the invention; and an aqueous diluent or solvent.

The invention provides for a solution, such as a phosphate buffered saline solution of the antisense oligonucleotide progranulin agonist of the invention, or the conjugate of the invention, or the pharmaceutically acceptable salt of the invention. Suitably the solution, such as phosphate buffered saline solution, of the invention, is a sterile solution.

The invention provides for a method for enhancing the expression of progranulin in a cell which is expressing progranulin, said method comprising administering an antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention in an effective amount to said cell. In some embodiments the method is an in vitro method. In some embodiments the method is an in vivo method.

In some embodiments, the cell is either a human cell or a mammalian cell.

The invention provides for a method for treating or preventing neurological disease, comprising administering a therapeutically or prophylactically effective amount of an antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the salt of the invention, or the pharmaceutical composition of the invention to a subject suffering from or susceptible to neurological disease. In one embodiment the neurological disease may be a TDP-43 pathology.

The invention provides for a method for treating progranulin haploinsufficiency disease, comprising administering a therapeutically or prophylactically effective amount of an antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the salt of the invention, or the pharmaceutical composition of the invention to a subject suffering from progranulin haploinsufficiency or a related disorder.

The invention provides for an antisense oligonucleotide progranulin agonist, for use as a medicament.

The invention provides for an antisense oligonucleotide progranulin agonist, for use in therapy.

The invention provides for the antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the salt of the invention, or the pharmaceutical composition of the invention, for use as a medicament.

The invention provides an antisense oligonucleotide progranulin agonist of the invention or the conjugate of the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention for use in therapy.

The invention provides for an antisense oligonucleotide progranulin agonist of the invention or the conjugate according to the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention for use in the treatment of a neurological disease. In one embodiment the neurological disease may be a TDP-43 pathology.

The invention provides for an antisense oligonucleotide progranulin agonist of the invention or the conjugate according to the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention for use in the treatment of progranulin haploinsufficiency, or a related disorder.

The invention provides for the use of an antisense oligonucleotide progranulin agonist of the invention or the conjugate according to the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention, for the preparation of a medicament for treatment or prevention of a neurological disease In one embodiment the neurological disease may be a TDP-43 pathology.

The invention provides for the use of the antisense oligonucleotide progranulin agonist of the invention or the conjugate according to the invention, or the salt according to the invention, or the pharmaceutical composition according to the invention, for the preparation of a medicament for treatment of progranulin haploinsufficiency or a related disorder.

In some embodiments the method or use of the invention is for the treatment of fronto temporal dementia (FTD), neuropathologic frontotemporal lobar degeneration or neuroinflammation. In other embodiments the method or use of the invention is for the treatment of amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Autism, Hippocampal sclerosis dementia, Down syndrome, Huntington's disease, polyglutamine diseases, spinocerebellar ataxia 3, myopathies or Chronic Traumatic Encephalopathy.

In one aspect the invention includes an oligonucleotide progranulin agonist having the structure:

embedded image

The invention also includes an antisense oligonucleotide progranulin agonist wherein the oligonucleotide is the oligonucleotide compound TgGccAggGatCagGG (SEQ ID NO: 106) wherein capital letters represent beta-D-oxy LNA nucleosides, lowercase letters represent DNA nucleosides, all LNA C are 5-methyl cytosine, and all internucleoside linkages are phosphorothioate internucleoside linkages.

BRIEF DESCRIPTION OF FIGURES

FIG. 1 shows progranulin expression levels in H4 neuroglioma cells following 5 days of treatment with 16-mer oligos targeting the progranulin 5′ UTR uORF region. Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364).

FIG. 2 shows localization of compounds #105, #106, #110 and #114 to the 5′ UTR of the proganulin mature mRNA transcript, targeting the uORF region.

FIGS. 3 and 4 show progranulin expression levels in H4 neuroglioma cells following 5 days of treatment with 16-mer oligos targeting 5′ UTR uORF region. Progranulin expression levels were evaluated in cell lysate (RIPA lysis and extraction buffer from Pierce cat. No. 89900) using the WES platform (ProteinSimple) and GRN antibody Invitrogen PA5-27275 diluted 1:25 and HPRT1 antibody ab109021 (Abcam) diluted 1:50.

FIG. 5 shows the level of progranulin expression in hiPSC derived microglia following 5 days of treatment with Compound #106. Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364).

FIG. 6 shows progranulin expression levels in H4 neuroglioma cells following 5 days of treatment with 18-mer oligos targeting the progranulin 5′ UTR uORF region. Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364).

FIG. 7 shows the structure of Compound ID #106 (SEQ ID NO 106).

FIG. 8 shows progranulin expression in H4 neuroglioma cells following treatment with Compound #106, Compound #106 full 2′MOE, and Compound #106 full 2′oMe.

FIG. 9 shows heat maps indicating genes upregulated and down regulated relative to PBS control treated cells. Left is compound #106, middle is Compound #106 full 2′oMe and right is Compound #106 full 2′MOE.

FIG. 10 is a plot showing the position of oligos within the progranulin precursor-mRNA (pre-mRNA) sequence (SEQ ID NO 3949) relative to the activity of the oligo. Oligos complementary to exon-exon junctions are plotted downstream of the schematic figure of the pre-mRNA

DEFINITIONS

Progranulin Agonist

The term “progranulin agonist” as used herein refers to a compound which is capable of enhancing the expression of progranulin transcripts and/or protein in a cell which is expressing progranulin.

TDP-43 Pathologies

A TDP-43 pathology is a disease which is associated with reduced or aberrant expression of TDP-43, often associated with an increase in cytoplasmic TDP-43, particularly hyper-phosphorylated and ubiquitinated TDP-43.

Diseases associated with TDP-43 pathology include amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease, Parkinson's disease, Autism, Hippocampal sclerosis dementia, Down syndrome, Huntington's disease, polyglutamine diseases, such as spinocerebellar ataxia 3, myopathies and Chronic Traumatic Encephalopathy.

Oligonucleotide

The term “oligonucleotide” as used herein is defined as it is generally understood by the skilled person as a molecule comprising two or more covalently linked nucleosides. Such covalently bound nucleosides may also be referred to as nucleic acid molecules or oligomers.

Oligonucleotides are commonly made in the laboratory by solid-phase chemical synthesis followed by purification and isolation. When referring to a sequence of the oligonucleotide, reference is made to the sequence or order of nucleobase moieties, or modifications thereof, of the covalently linked nucleotides or nucleosides. The oligonucleotides of the invention are man-made, and are chemically synthesized, and are typically purified or isolated. The oligonucleotides of the invention may comprise one or more modified nucleosides such as 2′ sugar modified nucleosides. The oligonucleotides of the invention may comprise one or more modified internucleoside linkages, such as one or more phosphorothioate internucleoside linkages.

Antisense Oligonucleotides

The term “antisense oligonucleotide” as used herein is defined as an oligonucleotide capable of modulating expression of a target gene by hybridizing to a target nucleic acid, in particular to a contiguous sequence on a target nucleic acid. Antisense oligonucleotides are not essentially double stranded and are therefore not siRNAs or shRNAs. The antisense oligonucleotides of the present invention may be single stranded. It is understood that single stranded oligonucleotides of the present invention can form hairpins or intermolecular duplex structures (duplex between two molecules of the same oligonucleotide), as long as the degree of intra or inter self-complementarity is less than approximately 50% across of the full length of the oligonucleotide.

In some embodiments, the single stranded antisense oligonucleotides of the invention may not contain RNA nucleosides.

Advantageously, the antisense oligonucleotides of the invention comprise one or more modified nucleosides or nucleotides, such as 2′ sugar modified nucleosides. Furthermore, in some antisense oligonucleotides of the invention, it may be advantageous that the nucleosides which are not modified are DNA nucleosides.

Contiguous Nucleotide Sequence

The term “contiguous nucleotide sequence” refers to the region of the oligonucleotide which is complementary to a target nucleic acid, which may be or may comprise an oligonucleotide motif sequence. The term is used interchangeably herein with the term “contiguous nucleobase sequence”. In some embodiments all the nucleosides of the oligonucleotide constitute the contiguous nucleotide sequence. The contiguous nucleotide sequence is the sequence of nucleotides in the oligonucleotide of the invention which are complementary to, and in some instances fully complementary to, the target nucleic acid or target sequence, or target site sequence.

In some embodiments the target sequence is SEQ ID NO 2.

SEQ ID NO 2:

TAGCCCTGATCCCTGGCCAATGGAAACTGAGGTAGG

In some embodiments the target sequence is selected from the group consisting of SEQ ID NO 343-682.

In some embodiments the target sequence is nucleotides 38-246 of SEQ ID NO 1.

In some embodiments the target sequence is selected from the group consisting of SEQ ID NO 568, SEQ ID NO 571, SEQ ID NO 575, SEQ ID NO 576, SEQ ID NO 577, SEQ ID NO 578, SEQ ID NO 584 & SEQ ID NO 586.

In some embodiments the target sequence is SEQ ID NO 683.

SEQ ID NO 683 = TGGCCAATGGAAACTGAGGTAGG

In some embodiments the target sequence is SEQ ID NO 684.

SEQ ID NO 684 = CCCTAGCACCTCCCCCTAACCAAATTCTCCCTG

In some embodiments the target sequence is SEQ ID NO 685.

SEQ ID NO 685 = CCCATTCTGAGCTCCCCATCA

In some embodiments the target sequence is SEQ ID NO 686.

SEQ ID NO 686 = AGGGGGTTGTGGCAAAAGCCA

In some embodiments the target sequence is SEQ ID NO 687.

SEQ ID NO 687 = CCATCCCCTCCCCGTTTCAGT

In some embodiments the target sequence is SEQ ID NO 688.

SEQ ID NO 688 = ATCCACAGGGGTGTTTGT

In some embodiments the target sequence is SEQ ID NO 689.

SEQ ID NO 689 = TAAGTAGCCAATGGGAGCGGGTAGCCCTGATCCC

TGGCCAATGGAAACTGAGGTAGG

SEQ ID NO 689 is in the human progranulin mature mRNA 5′ UTR from position 119 to 158 according to RefSeq NM_002087 (SEQ ID NO 1), as targeted by SEQ ID NOs 207 to 246 and identified herein as an advantageous region to target for progranulin agonist activity.

In some embodiments the target sequence is nucleotides 2039-2346 of SEQ ID NO 1.

In some embodiments the target sequence is selected from the group consisting of SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 683, SEQ ID NO 686, SEQ ID NO 687, and SEQ ID NO 688.

In some embodiments the target sequence is selected from the group consisting of SEQ ID NO 607, SEQ ID NO 608, SEQ ID NO 609, SEQ ID NO 610, SEQ ID NO 611, SEQ ID NO 612, SEQ ID NO 619, SEQ ID NO 620, SEQ ID NO 633, SEQ ID NO 640, SEQ ID NO 641, SEQ ID NO 645, SEQ ID NO 651, and SEQ ID NO 652.

In some embodiments the target sequence is selected from the group consisting of SEQ ID NO 2040-3386.

In some embodiments the target sequence is selected from the group consisting of SEQ ID 2321, SEQ ID 2322, SEQ ID 2324, SEQ ID 2328, SEQ ID 2329, SEQ ID 2331, SEQ ID 2334, SEQ ID 2335, SEQ ID 2336, SEQ ID 2337, SEQ ID 2338, SEQ ID 2339, SEQ ID 2340, SEQ ID 2341, SEQ ID 2342, SEQ ID 2345, SEQ ID 2346, SEQ ID 2347, SEQ ID 2348, SEQ ID 2349, SEQ ID 2350, SEQ ID 2351, SEQ ID 2352, SEQ ID 2353, SEQ ID 2354, SEQ ID 2355, SEQ ID 2356, SEQ ID 2357, SEQ ID 2358, SEQ ID 2359, SEQ ID 2360, SEQ ID 2361, SEQ ID 2362, SEQ ID 2364, SEQ ID 2365, SEQ ID 2366, SEQ ID 2367, SEQ ID 2368, SEQ ID 2369, SEQ ID 2370, SEQ ID 2371, SEQ ID 2372, SEQ ID 2373, SEQ ID 2374, SEQ ID 2375, SEQ ID 2376, SEQ ID 2377, SEQ ID 2378, SEQ ID 2379, SEQ ID 2380, SEQ ID 2381, SEQ ID 2384, SEQ ID 2386, SEQ ID 2387, SEQ ID 2388, SEQ ID 2389, SEQ ID 2390, SEQ ID 2392, SEQ ID 2393, SEQ ID 2394, SEQ ID 2395, SEQ ID 2396, SEQ ID 2397, SEQ ID 2398, SEQ ID 2399, SEQ ID 2400, SEQ ID 2401, SEQ ID 2403, SEQ ID 2404, SEQ ID 2405, SEQ ID 2406, SEQ ID 2407, SEQ ID 2408, SEQ ID 2410, SEQ ID 2411, SEQ ID 2413, SEQ ID 2414, SEQ ID 2415, SEQ ID 2416, SEQ ID 2418, SEQ ID 2419, SEQ ID 2421, SEQ ID 2424, SEQ ID 2425, SEQ ID 2426, SEQ ID 2427, SEQ ID 2428, SEQ ID 2429, SEQ ID 2430, SEQ ID 2431, SEQ ID 2432, SEQ ID 2433, SEQ ID 2434, SEQ ID 2435, SEQ ID 2436, SEQ ID 2437, SEQ ID 2438, SEQ ID 2439, SEQ ID 2440, SEQ ID 2441, SEQ ID 2442, SEQ ID 2443, SEQ ID 2444, SEQ ID 2445, SEQ ID 2446, SEQ ID 2447, SEQ ID 2448, SEQ ID 2449, SEQ ID 2450, SEQ ID 2451, SEQ ID 2452, SEQ ID 2453, SEQ ID 2454, SEQ ID 2455, SEQ ID 2456, SEQ ID 2457, SEQ ID 2458, SEQ ID 2459, SEQ ID 2460, SEQ ID 2461, SEQ ID 2462, SEQ ID 2463, SEQ ID 2464, SEQ ID 2465, SEQ ID 2466, SEQ ID 2467, SEQ ID 2468, SEQ ID 2469, SEQ ID 2470, SEQ ID 2471, SEQ ID 2472, SEQ ID 2473, SEQ ID 2474, SEQ ID 2475, SEQ ID 2476, SEQ ID 2477, SEQ ID 2478, SEQ ID 2479, SEQ ID 2481, SEQ ID 2482, SEQ ID 2483, SEQ ID 2484, SEQ ID 2485, SEQ ID 2487, SEQ ID 2489, SEQ ID 2490, SEQ ID 2491, SEQ ID 2492, SEQ ID 2493, SEQ ID 2494, SEQ ID 2495, SEQ ID 2496, SEQ ID 2497, SEQ ID 2498, SEQ ID 2499, SEQ ID 2501, SEQ ID 2502, SEQ ID 2503, SEQ ID 2504, SEQ ID 2505, SEQ ID 2506, SEQ ID 2507, SEQ ID 2508, SEQ ID 2509, SEQ ID 2510, SEQ ID 2511, SEQ ID 2512, SEQ ID 2513, SEQ ID 2514, SEQ ID 2515, SEQ ID 2516, SEQ ID 2518, SEQ ID 2519, SEQ ID 2520, SEQ ID 2521, SEQ ID 2522, SEQ ID 2523, SEQ ID 2524, SEQ ID 2525, SEQ ID 2526, SEQ ID 2527, SEQ ID 2528, SEQ ID 2531, SEQ ID 2533, SEQ ID 2534, SEQ ID 2535, SEQ ID 2536, SEQ ID 2537, SEQ ID 2538, SEQ ID 2540, SEQ ID 2541, SEQ ID 2542, SEQ ID 2544, SEQ ID 2546, SEQ ID 2547, SEQ ID 2549, SEQ ID 2550, SEQ ID 2551, SEQ ID 2553, SEQ ID 2554, SEQ ID 2555, SEQ ID 2556, SEQ ID 2557, SEQ ID 2560, SEQ ID 2561, SEQ ID 2562, SEQ ID 2563, SEQ ID 2565, SEQ ID 2566, SEQ ID 2567, SEQ ID 2572, SEQ ID 2573, SEQ ID 2574, SEQ ID 2575, SEQ ID 2576, SEQ ID 2577, SEQ ID 2578, SEQ ID 2579, SEQ ID 2580, SEQ ID 2581, SEQ ID 2582, SEQ ID 2583, SEQ ID 2584, SEQ ID 2585, SEQ ID 2586, SEQ ID 2588, SEQ ID 2589, SEQ ID 2590, SEQ ID 2591, SEQ ID 2592, SEQ ID 2593, SEQ ID 2594, SEQ ID 2595, SEQ ID 2596, SEQ ID 2597, SEQ ID 2598, SEQ ID 2599, SEQ ID 2601, SEQ ID 2602, SEQ ID 2603, SEQ ID 2604, SEQ ID 2606, SEQ ID 2610, SEQ ID 2613, SEQ ID 2614, SEQ ID 2615, SEQ ID 2619, SEQ ID 2622, SEQ ID 2623, SEQ ID 2624, SEQ ID 2625, SEQ ID 2626, SEQ ID 2627, SEQ ID 2628, SEQ ID 2629, SEQ ID 2630, SEQ ID 2631, SEQ ID 2632, SEQ ID 2633, SEQ ID 2634, SEQ ID 2635, SEQ ID 2636, SEQ ID 2637, SEQ ID 2638, SEQ ID 2639, SEQ ID 2640, SEQ ID 2641, SEQ ID 2642, SEQ ID 2643, SEQ ID 2644, SEQ ID 2645, SEQ ID 2646, SEQ ID 2647, SEQ ID 2648, SEQ ID 2649, SEQ ID 2650, SEQ ID 2651, SEQ ID 2652, SEQ ID 2653, SEQ ID 2654, SEQ ID 2655, SEQ ID 2656, SEQ ID 2658, SEQ ID 2659, SEQ ID 2660, SEQ ID 2661, SEQ ID 2662, SEQ ID 2663, SEQ ID 2664, SEQ ID 2665, SEQ ID 2666, SEQ ID 2667, SEQ ID 2668, SEQ ID 2669, SEQ ID 2670, SEQ ID 2671, SEQ ID 2672, SEQ ID 2673, SEQ ID 2674, SEQ ID 2675, SEQ ID 2676, SEQ ID 2677, SEQ ID 2678, SEQ ID 2679, SEQ ID 2680, SEQ ID 2681, SEQ ID 2682, SEQ ID 2683, SEQ ID 2684, SEQ ID 2685, SEQ ID 2686, SEQ ID 2687, SEQ ID 2688, SEQ ID 2689, SEQ ID 2690, SEQ ID 2691, SEQ ID 2693, SEQ ID 2694, SEQ ID 2695, SEQ ID 2696, SEQ ID 2697, SEQ ID 2698, SEQ ID 2699, SEQ ID 2700, SEQ ID 2701, SEQ ID 2702, SEQ ID 2703, SEQ ID 2704, SEQ ID 2705, SEQ ID 2706, SEQ ID 2707, SEQ ID 2708, SEQ ID 2709, SEQ ID 2710, SEQ ID 2711, SEQ ID 2712, SEQ ID 2713, SEQ ID 2714, SEQ ID 2715, SEQ ID 2716, SEQ ID 2717, SEQ ID 2718, SEQ ID 2719, SEQ ID 2720, SEQ ID 2721, SEQ ID 2722, SEQ ID 2723, SEQ ID 2726, SEQ ID 2727, SEQ ID 2728, SEQ ID 2729, SEQ ID 2730, SEQ ID 2733, SEQ ID 2734, SEQ ID 2735, SEQ ID 2736, SEQ ID 2737, SEQ ID 2738, SEQ ID 2739, SEQ ID 2740, SEQ ID 2741, SEQ ID 2742, SEQ ID 2743, SEQ ID 2744, SEQ ID 2745, SEQ ID 2746, SEQ ID 2747, SEQ ID 2748, SEQ ID 2749, SEQ ID 2750, SEQ ID 2751, SEQ ID 2752, SEQ ID 2753, SEQ ID 2754, SEQ ID 2755, SEQ ID 2756, SEQ ID 2757, SEQ ID 2758, SEQ ID 2759, SEQ ID 2760, SEQ ID 2761, SEQ ID 2762, SEQ ID 2763, SEQ ID 2764, SEQ ID 2765, SEQ ID 2766, SEQ ID 2767, SEQ ID 2768, SEQ ID 2769, SEQ ID 2770, SEQ ID 2771, SEQ ID 2772, SEQ ID 2773, SEQ ID 2774, SEQ ID 2775, SEQ ID 2815, SEQ ID 2816, SEQ ID 2817, SEQ ID 2818, SEQ ID 2819, SEQ ID 2820, SEQ ID 2821, SEQ ID 2822, SEQ ID 2823, SEQ ID 2824, SEQ ID 2825, SEQ ID 2826, SEQ ID 2827, SEQ ID 2828, SEQ ID 2829, SEQ ID 2830, SEQ ID 2831, SEQ ID 2832, SEQ ID 2833, SEQ ID 2834, SEQ ID 2835, SEQ ID 2836, SEQ ID 2837, SEQ ID 2838, SEQ ID 2839, SEQ ID 2840, SEQ ID 2841, SEQ ID 2842, SEQ ID 2843, SEQ ID 2844, SEQ ID 2845, SEQ ID 2847, SEQ ID 2848, SEQ ID 2849, SEQ ID 2850, SEQ ID 2851, SEQ ID 2852, SEQ ID 2853, SEQ ID 2854, SEQ ID 2855, SEQ ID 2858, SEQ ID 2859, SEQ ID 2860, SEQ ID 2861, SEQ ID 2862, SEQ ID 2863, SEQ ID 2864, SEQ ID 2865, SEQ ID 2866, SEQ ID 2867, SEQ ID 2868, SEQ ID 2869, SEQ ID 2870, SEQ ID 2871, SEQ ID 2872, SEQ ID 2873, SEQ ID 2874, SEQ ID 2875, SEQ ID 2876, SEQ ID 2878, SEQ ID 2879, SEQ ID 2880, SEQ ID 2881, SEQ ID 2882, SEQ ID 2883, SEQ ID 2884, SEQ ID 2885, SEQ ID 2886, SEQ ID 2887, SEQ ID 2888, SEQ ID 2889, SEQ ID 2890, SEQ ID 2891, SEQ ID 2892, SEQ ID 2893, SEQ ID 2894, SEQ ID 2895, SEQ ID 2896, SEQ ID 2897, SEQ ID 2898, SEQ ID 2899, SEQ ID 2900, SEQ ID 2901, SEQ ID 2902, SEQ ID 2903, SEQ ID 2904, SEQ ID 2905, SEQ ID 2906, SEQ ID 2907, SEQ ID 2908, SEQ ID 2909, SEQ ID 2910, SEQ ID 2911, SEQ ID 2912, SEQ ID 2913, SEQ ID 2914, SEQ ID 2915, SEQ ID 2916, SEQ ID 2917, SEQ ID 2918, SEQ ID 2919, SEQ ID 2920, SEQ ID 2921, SEQ ID 2922, SEQ ID 2923, SEQ ID 2924, SEQ ID 2925, SEQ ID 2926, SEQ ID 2927, SEQ ID 2928, SEQ ID 2929, SEQ ID 2930, SEQ ID 2931, SEQ ID 2932, SEQ ID 2934, SEQ ID 2935, SEQ ID 2936, SEQ ID 2937, SEQ ID 2938, SEQ ID 2939, SEQ ID 2940, SEQ ID 2941, SEQ ID 2942, SEQ ID 2943, SEQ ID 2944, SEQ ID 2945, SEQ ID 2946, SEQ ID 2947, SEQ ID 2948, SEQ ID 2949, SEQ ID 2950, SEQ ID 2951, SEQ ID 2953, SEQ ID 2954, SEQ ID 2955, SEQ ID 2956, SEQ ID 2957, SEQ ID 2958, SEQ ID 2960, SEQ ID 2961, SEQ ID 2963, SEQ ID 2964, SEQ ID 2965, SEQ ID 2966, SEQ ID 2967, SEQ ID 2969, SEQ ID 2970, SEQ ID 2971, SEQ ID 2972, SEQ ID 2973, SEQ ID 2974, SEQ ID 2975, SEQ ID 2976, SEQ ID 2977, SEQ ID 2978, SEQ ID 2979, SEQ ID 2980, SEQ ID 2981, SEQ ID 2982, SEQ ID 2983, SEQ ID 2984, SEQ ID 2985, SEQ ID 3053, SEQ ID 3054, SEQ ID 3055, SEQ ID 3056, SEQ ID 3057, SEQ ID 3058, SEQ ID 3059, SEQ ID 3060, SEQ ID 3061, SEQ ID 3062, SEQ ID 3063, SEQ ID 3064, SEQ ID 3065, SEQ ID 3066, SEQ ID 3068, SEQ ID 3069, SEQ ID 3070, SEQ ID 3071, SEQ ID 3072, SEQ ID 3073, SEQ ID 3074, SEQ ID 3075, SEQ ID 3076, SEQ ID 3077, SEQ ID 3078, SEQ ID 3079, SEQ ID 3080, SEQ ID 3081, SEQ ID 3082, SEQ ID 3083, SEQ ID 3084, SEQ ID 3085, SEQ ID 3086, SEQ ID 3087, SEQ ID 3088, SEQ ID 3089, SEQ ID 3090, SEQ ID 3091, SEQ ID 3092, SEQ ID 3093, SEQ ID 3094, SEQ ID 3095, SEQ ID 3097, SEQ ID 3098, SEQ ID 3099, SEQ ID 3100, SEQ ID 3102, SEQ ID 3103, SEQ ID 3104, SEQ ID 3105, SEQ ID 3106, SEQ ID 3107, SEQ ID 3108, SEQ ID 3109, SEQ ID 3110, SEQ ID 3112, SEQ ID 3113, SEQ ID 3115, SEQ ID 3116, SEQ ID 3117, SEQ ID 3119, SEQ ID 3120, SEQ ID 3121, SEQ ID 3122, SEQ ID 3123, SEQ ID 3124, SEQ ID 3125, SEQ ID 3126, SEQ ID 3127, SEQ ID 3128, SEQ ID 3129, SEQ ID 3130, SEQ ID 3131, SEQ ID 3132, SEQ ID 3133, SEQ ID 3134, SEQ ID 3135, SEQ ID 3136, SEQ ID 3137, SEQ ID 3138, SEQ ID 3139, SEQ ID 3140, SEQ ID 3141, SEQ ID 3142, SEQ ID 3143, SEQ ID 3144, SEQ ID 3145, SEQ ID 3146, SEQ ID 3147, SEQ ID 3148, SEQ ID 3149, SEQ ID 3150, SEQ ID 3151, SEQ ID 3152, SEQ ID 3153, SEQ ID 3154, SEQ ID 3155, SEQ ID 3156, SEQ ID 3157, SEQ ID 3158, SEQ ID 3159, SEQ ID 3160, SEQ ID 3161, SEQ ID 3162, SEQ ID 3163, SEQ ID 3164, SEQ ID 3165, SEQ ID 3166, SEQ ID 3167, SEQ ID 3168, SEQ ID 3169, SEQ ID 3170, SEQ ID 3171, SEQ ID 3172, SEQ ID 3173, SEQ ID 3174, SEQ ID 3175, SEQ ID 3176, SEQ ID 3177, SEQ ID 3178, SEQ ID 3179, SEQ ID 3180, SEQ ID 3181, SEQ ID 3182, SEQ ID 3183, SEQ ID 3184, SEQ ID 3185, SEQ ID 3186, SEQ ID 3187, SEQ ID 3188, SEQ ID 3189, SEQ ID 3190, SEQ ID 3191, SEQ ID 3192, SEQ ID 3193, SEQ ID 3194, SEQ ID 3195, SEQ ID 3196, SEQ ID 3197, SEQ ID 3198, SEQ ID 3199, SEQ ID 3200, SEQ ID 3201, SEQ ID 3202, SEQ ID 3203, SEQ ID 3204, SEQ ID 3205, SEQ ID 3206, SEQ ID 3207, SEQ ID 3208, SEQ ID 3209, SEQ ID 3210, SEQ ID 3211, SEQ ID 3212, SEQ ID 3213, SEQ ID 3214, SEQ ID 3215, SEQ ID 3216, SEQ ID 3217, SEQ ID 3218, SEQ ID 3219, SEQ ID 3220, SEQ ID 3221, SEQ ID 3222, SEQ ID 3223, SEQ ID 3224, SEQ ID 3225, SEQ ID 3226, SEQ ID 3227, SEQ ID 3228, SEQ ID 3229, SEQ ID 3230, SEQ ID 3231, SEQ ID 3232, SEQ ID 3233, SEQ ID 3234, SEQ ID 3235, SEQ ID 3236, SEQ ID 3237, SEQ ID 3238, SEQ ID 3239, SEQ ID 3240, SEQ ID 3241, SEQ ID 3242, SEQ ID 3243, SEQ ID 3244, SEQ ID 3245, SEQ ID 3246, SEQ ID 3248, SEQ ID 3249, SEQ ID 3250, SEQ ID 3251, SEQ ID 3252, SEQ ID 3253, SEQ ID 3254, SEQ ID 3255, SEQ ID 3256, SEQ ID 3257, SEQ ID 3258, SEQ ID 3259, SEQ ID 3260, SEQ ID 3261, SEQ ID 3262, SEQ ID 3263, SEQ ID 3264, SEQ ID 3265, SEQ ID 3266, SEQ ID 3267, SEQ ID 3268, SEQ ID 3269, SEQ ID 3270, SEQ ID 3271, SEQ ID 3272, SEQ ID 3273, SEQ ID 3275, SEQ ID 3276, SEQ ID 3277, SEQ ID 3278, SEQ ID 3279, SEQ ID 3280, SEQ ID 3282, SEQ ID 3284, SEQ ID 3285, SEQ ID 3286, SEQ ID 3287, SEQ ID 3288, SEQ ID 3289, SEQ ID 3291, SEQ ID 3292, SEQ ID 3293, SEQ ID 3294, SEQ ID 3295, SEQ ID 3296, SEQ ID 3297, SEQ ID 3298, SEQ ID 3299, SEQ ID 3300, SEQ ID 3301, SEQ ID 3302, SEQ ID 3303, SEQ ID 3304, SEQ ID 3305, SEQ ID 3306, SEQ ID 3307, SEQ ID 3308, SEQ ID 3309, SEQ ID 3310, SEQ ID 3311, SEQ ID 3312, SEQ ID 3313, SEQ ID 3314, SEQ ID 3315, SEQ ID 3316, SEQ ID 3317, SEQ ID 3318, SEQ ID 3320, SEQ ID 3321, SEQ ID 3322, SEQ ID 3323, SEQ ID 3324, SEQ ID 3325, SEQ ID 3326, SEQ ID 3327, SEQ ID 3329, SEQ ID 3331, SEQ ID 3332, SEQ ID 3333, SEQ ID 3334, SEQ ID 3335, SEQ ID 3336, SEQ ID 3337, SEQ ID 3338, SEQ ID 3339, SEQ ID 3340, SEQ ID 3342, SEQ ID 3343, SEQ ID 3344, SEQ ID 3345, SEQ ID 3346, SEQ ID 3347, SEQ ID 3348, SEQ ID 3349, SEQ ID 3350, SEQ ID 3351, SEQ ID 3352, SEQ ID 3353, SEQ ID 3354, SEQ ID 3355, SEQ ID 3356, SEQ ID 3357, SEQ ID 3358, SEQ ID 3359, SEQ ID 3360, SEQ ID 3361, SEQ ID 3362, SEQ ID 3363, SEQ ID 3364, SEQ ID 3365, SEQ ID 3366, SEQ ID 3367, SEQ ID 3368, SEQ ID 3369, SEQ ID 3370, SEQ ID 3371, SEQ ID 3390, SEQ ID 3391, SEQ ID 3392, SEQ ID 3393, SEQ ID 3394, SEQ ID 3395, SEQ ID 3396, SEQ ID 3397, SEQ ID 3398, SEQ ID 3399, SEQ ID 3400, SEQ ID 3401, SEQ ID 3402, SEQ ID 3403, SEQ ID 3404, SEQ ID 3405, SEQ ID 3406, SEQ ID 3407, SEQ ID 3408, SEQ ID 3409, SEQ ID 3410, SEQ ID 3411, SEQ ID 3412, SEQ ID 3413, SEQ ID 3414, SEQ ID 3415, SEQ ID 3416, SEQ ID 3417, SEQ ID 3418, SEQ ID 3419, SEQ ID 3420, SEQ ID 3421, SEQ ID 3422, SEQ ID 3423, SEQ ID 3424, SEQ ID 3425, SEQ ID 3426, SEQ ID 3427, SEQ ID 3428, SEQ ID 3429, SEQ ID 3430, SEQ ID 3431, SEQ ID 3432, SEQ ID 3433, SEQ ID 3434, SEQ ID 3435, SEQ ID 3436, SEQ ID 3437, SEQ ID 3438, SEQ ID 3439, SEQ ID 3440, SEQ ID 3441, SEQ ID 3442, SEQ ID 3443, SEQ ID 3444, SEQ ID 3445, SEQ ID 3446, SEQ ID 3447, SEQ ID 3448, SEQ ID 3449, SEQ ID 3450, SEQ ID 3451, SEQ ID 3452, SEQ ID 3453, SEQ ID 3454, SEQ ID 3460, SEQ ID 3461, SEQ ID 3464, SEQ ID 3465, SEQ ID 3466, SEQ ID 3467, SEQ ID 3468, SEQ ID 3486, SEQ ID 3487, SEQ ID 3488, SEQ ID 3489, SEQ ID 3490, SEQ ID 3491, SEQ ID 3493, SEQ ID 3494, SEQ ID 3496, SEQ ID 3497, SEQ ID 3501, SEQ ID 3505, SEQ ID 3508, SEQ ID 3511, SEQ ID 3512, SEQ ID 3516, SEQ ID 3517, SEQ ID 3518, SEQ ID 3521, SEQ ID 3522, SEQ ID 3523, SEQ ID 3524, SEQ ID 3525, SEQ ID 3526, SEQ ID 3527, SEQ ID 3528, SEQ ID 3530, SEQ ID 3531, SEQ ID 3532, SEQ ID 3534, SEQ ID 3535, SEQ ID 3536, SEQ ID 3538, SEQ ID 3539, SEQ ID 3541, SEQ ID 3542, SEQ ID 3543, SEQ ID 3544, SEQ ID 3546, SEQ ID 3548, SEQ ID 3549, SEQ ID 3550, SEQ ID 3552, SEQ ID 3556, SEQ ID 3557, SEQ ID 3558, SEQ ID 3560, SEQ ID 3561, SEQ ID 3566, SEQ ID 3567, SEQ ID 3568, SEQ ID 3569, SEQ ID 3571, SEQ ID 3572, SEQ ID 3573, SEQ ID 3574, SEQ ID 3576, SEQ ID 3577, SEQ ID 3578, SEQ ID 3580, SEQ ID 3581, SEQ ID 3584, SEQ ID 3585, SEQ ID 3586, SEQ ID 3588, SEQ ID 3590, SEQ ID 3592, SEQ ID 3594, SEQ ID 3595, SEQ ID 3598, SEQ ID 3599, SEQ ID 3600, SEQ ID 3601, SEQ ID 3602, SEQ ID 3603, SEQ ID 3605, SEQ ID 3607, SEQ ID 3609, SEQ ID 3610, SEQ ID 3613, SEQ ID 3614, SEQ ID 3615, SEQ ID 3616, SEQ ID 3617, SEQ ID 3621, SEQ ID 3623, SEQ ID 3624, SEQ ID 3625, SEQ ID 3626, SEQ ID 3627, SEQ ID 3628, SEQ ID 3629, SEQ ID 3630, SEQ ID 3631, SEQ ID 3632, SEQ ID 3633, SEQ ID 3636, SEQ ID 3637, SEQ ID 3638, SEQ ID 3639, SEQ ID 3641, SEQ ID 3642, SEQ ID 3643, SEQ ID 3645, SEQ ID 3647, SEQ ID 3648, SEQ ID 3649, SEQ ID 3651, SEQ ID 3654, SEQ ID 3656, SEQ ID 3659, SEQ ID 3660, SEQ ID 3661, SEQ ID 3663, SEQ ID 3664, SEQ ID 3665, SEQ ID 3666, SEQ ID 3670, SEQ ID 3672, SEQ ID 3676, SEQ ID 3678, SEQ ID 3679, SEQ ID 3680, SEQ ID 3681, SEQ ID 3682, SEQ ID 3683, SEQ ID 3684, SEQ ID 3685, SEQ ID 3686, SEQ ID 3687, SEQ ID 3688, SEQ ID 3689, SEQ ID 3690, SEQ ID 3691, SEQ ID 3692, SEQ ID 3693, SEQ ID 3694, SEQ ID 3695, SEQ ID 3696, SEQ ID 3697, SEQ ID 3698, SEQ ID 3699, SEQ ID 3700, SEQ ID 3701, SEQ ID 3702, SEQ ID 3703, SEQ ID 3704, SEQ ID 3705, SEQ ID 3706, SEQ ID 3707, SEQ ID 3708, SEQ ID 3709, SEQ ID 3710, SEQ ID 3711, SEQ ID 3712, SEQ ID 3713, SEQ ID 3714, SEQ ID 3715, SEQ ID 3716, SEQ ID 3717, SEQ ID 3718, SEQ ID 3719, SEQ ID 3720, SEQ ID 3721, SEQ ID 3722, SEQ ID 3723, SEQ ID 3724, SEQ ID 3725, SEQ ID 3726, SEQ ID 3727, SEQ ID 3729, SEQ ID 3730, SEQ ID 3731, SEQ ID 3732, SEQ ID 3733, SEQ ID 3734, SEQ ID 3735, SEQ ID 3736, SEQ ID 3737, SEQ ID 3738, SEQ ID 3739, SEQ ID 3740, SEQ ID 3741, SEQ ID 3742, SEQ ID 3743, SEQ ID 3744, SEQ ID 3745, SEQ ID 3746, SEQ ID 3747, SEQ ID 3748, SEQ ID 3749, SEQ ID 3750, SEQ ID 3751, SEQ ID 3752, SEQ ID 3753, SEQ ID 3754, SEQ ID 3755, SEQ ID 3774, SEQ ID 3775, SEQ ID 3776, SEQ ID 3777, SEQ ID 3778, SEQ ID 3779, SEQ ID 3780, SEQ ID 3781, SEQ ID 3782, SEQ ID 3783, SEQ ID 3784, SEQ ID 3785, SEQ ID 3786, SEQ ID 3787, SEQ ID 3788, SEQ ID 3789, SEQ ID 3790, SEQ ID 3791, SEQ ID 3792, SEQ ID 3793, SEQ ID 3794, SEQ ID 3795, SEQ ID 3796, SEQ ID 3797, SEQ ID 3798, SEQ ID 3799, SEQ ID 3800, SEQ ID 3801, SEQ ID 3802, SEQ ID 3803, SEQ ID 3804, SEQ ID 3805, SEQ ID 3806, SEQ ID 3807, SEQ ID 3808, SEQ ID 3809, SEQ ID 3810, SEQ ID 3811, SEQ ID 3812, SEQ ID 3813, SEQ ID 3814, SEQ ID 3815, SEQ ID 3816, SEQ ID 3817, SEQ ID 3818, SEQ ID 3819, SEQ ID 3820, SEQ ID 3821, SEQ ID 3822, SEQ ID 3823, SEQ ID 3824, SEQ ID 3825, SEQ ID 3826, SEQ ID 3827, SEQ ID 3828, SEQ ID 3829, SEQ ID 3830, SEQ ID 3831, SEQ ID 3832, SEQ ID 3833, SEQ ID 3834, SEQ ID 3835, SEQ ID 3836, SEQ ID 3837, SEQ ID 3838, SEQ ID 3839, SEQ ID 3840, SEQ ID 3841, SEQ ID 3842, SEQ ID 3844, SEQ ID 3848, SEQ ID 3850, SEQ ID 3851, SEQ ID 3852, SEQ ID 3853, SEQ ID 3867, SEQ ID 3868, SEQ ID 3869, SEQ ID 3870, SEQ ID 3871, SEQ ID 3872, SEQ ID 3873, SEQ ID 3874, SEQ ID 3875, SEQ ID 3876, SEQ ID 3877, SEQ ID 3878, SEQ ID 3879, SEQ ID 3880, SEQ ID 3881, SEQ ID 3882, SEQ ID 3883, SEQ ID 3884, SEQ ID 3885, SEQ ID 3886, SEQ ID 3887, SEQ ID 3888, SEQ ID 3889, SEQ ID 3890, SEQ ID 3891, SEQ ID 3892, SEQ ID 3893, SEQ ID 3894, SEQ ID 3895, SEQ ID 3896, SEQ ID 3897, SEQ ID 3898, SEQ ID 3899, SEQ ID 3900, SEQ ID 3901, SEQ ID 3902, SEQ ID 3903, SEQ ID 3904, SEQ ID 3905, SEQ ID 3906, SEQ ID 3907, SEQ ID 3908, SEQ ID 3909, SEQ ID 3910, SEQ ID 3911, SEQ ID 3912, SEQ ID 3913, SEQ ID 3914, SEQ ID 3915, SEQ ID 3916, SEQ ID 3917, SEQ ID 3918, SEQ ID 3919, SEQ ID 3920, SEQ ID 3921, SEQ ID 3922, SEQ ID 3923, SEQ ID 3924, SEQ ID 3925, SEQ ID 3926, SEQ ID 3927, SEQ ID 3928, SEQ ID 3929, SEQ ID 3930, SEQ ID 3931, SEQ ID 3932, SEQ ID 3933, SEQ ID 3934, SEQ ID 3935, SEQ ID 3936, SEQ ID 3937, SEQ ID 3938, SEQ ID 3939, SEQ ID 3940, SEQ ID 3941, SEQ ID 3942, SEQ ID 3943, SEQ ID 3944, SEQ ID 3945, SEQ ID 3946, SEQ ID 3947, and SEQ ID 3948.

In some embodiments the target sequence is selected from the group consisting of SEQ ID 2321, SEQ ID 2335, SEQ ID 2336, SEQ ID 2337, SEQ ID 2338, SEQ ID 2339, SEQ ID 2348, SEQ ID 2349, SEQ ID 2351, SEQ ID 2352, SEQ ID 2353, SEQ ID 2354, SEQ ID 2355, SEQ ID 2358, SEQ ID 2360, SEQ ID 2364, SEQ ID 2365, SEQ ID 2366, SEQ ID 2367, SEQ ID 2369, SEQ ID 2371, SEQ ID 2373, SEQ ID 2375, SEQ ID 2386, SEQ ID 2387, SEQ ID 2388, SEQ ID 2389, SEQ ID 2394, SEQ ID 2403, SEQ ID 2426, SEQ ID 2428, SEQ ID 2429, SEQ ID 2430, SEQ ID 2431, SEQ ID 2432, SEQ ID 2435, SEQ ID 2440, SEQ ID 2441, SEQ ID 2442, SEQ ID 2444, SEQ ID 2446, SEQ ID 2447, SEQ ID 2450, SEQ ID 2451, SEQ ID 2452, SEQ ID 2453, SEQ ID 2454, SEQ ID 2455, SEQ ID 2456, SEQ ID 2458, SEQ ID 2459, SEQ ID 2461, SEQ ID 2463, SEQ ID 2464, SEQ ID 2465, SEQ ID 2466, SEQ ID 2467, SEQ ID 2468, SEQ ID 2469, SEQ ID 2470, SEQ ID 2471, SEQ ID 2472, SEQ ID 2473, SEQ ID 2474, SEQ ID 2475, SEQ ID 2476, SEQ ID 2477, SEQ ID 2478, SEQ ID 2482, SEQ ID 2483, SEQ ID 2484, SEQ ID 2485, SEQ ID 2487, SEQ ID 2489, SEQ ID 2494, SEQ ID 2495, SEQ ID 2496, SEQ ID 2497, SEQ ID 2499, SEQ ID 2501, SEQ ID 2502, SEQ ID 2504, SEQ ID 2506, SEQ ID 2507, SEQ ID 2508, SEQ ID 2509, SEQ ID 2511, SEQ ID 2513, SEQ ID 2515, SEQ ID 2516, SEQ ID 2518, SEQ ID 2519, SEQ ID 2520, SEQ ID 2521, SEQ ID 2523, SEQ ID 2525, SEQ ID 2534, SEQ ID 2537, SEQ ID 2544, SEQ ID 2546, SEQ ID 2554, SEQ ID 2555, SEQ ID 2556, SEQ ID 2560, SEQ ID 2561, SEQ ID 2562, SEQ ID 2595, SEQ ID 2626, SEQ ID 2628, SEQ ID 2629, SEQ ID 2630, SEQ ID 2631, SEQ ID 2633, SEQ ID 2638, SEQ ID 2639, SEQ ID 2640, SEQ ID 2649, SEQ ID 2651, SEQ ID 2652, SEQ ID 2655, SEQ ID 2658, SEQ ID 2665, SEQ ID 2666, SEQ ID 2667, SEQ ID 2669, SEQ ID 2670, SEQ ID 2676, SEQ ID 2677, SEQ ID 2678, SEQ ID 2679, SEQ ID 2682, SEQ ID 2686, SEQ ID 2688, SEQ ID 2689, SEQ ID 2691, SEQ ID 2694, SEQ ID 2698, SEQ ID 2699, SEQ ID 2700, SEQ ID 2701, SEQ ID 2703, SEQ ID 2706, SEQ ID 2709, SEQ ID 2711, SEQ ID 2712, SEQ ID 2713, SEQ ID 2714, SEQ ID 2719, SEQ ID 2720, SEQ ID 2721, SEQ ID 2737, SEQ ID 2739, SEQ ID 2740, SEQ ID 2741, SEQ ID 2742, SEQ ID 2743, SEQ ID 2744, SEQ ID 2745, SEQ ID 2746, SEQ ID 2747, SEQ ID 2748, SEQ ID 2749, SEQ ID 2750, SEQ ID 2751, SEQ ID 2752, SEQ ID 2753, SEQ ID 2754, SEQ ID 2755, SEQ ID 2756, SEQ ID 2757, SEQ ID 2758, SEQ ID 2760, SEQ ID 2763, SEQ ID 2764, SEQ ID 2765, SEQ ID 2766, SEQ ID 2767, SEQ ID 2768, SEQ ID 2769, SEQ ID 2770, SEQ ID 2771, SEQ ID 2772, SEQ ID 2774, SEQ ID 2816, SEQ ID 2817, SEQ ID 2818, SEQ ID 2819, SEQ ID 2820, SEQ ID 2824, SEQ ID 2828, SEQ ID 2829, SEQ ID 2830, SEQ ID 2831, SEQ ID 2832, SEQ ID 2833, SEQ ID 2834, SEQ ID 2835, SEQ ID 2836, SEQ ID 2837, SEQ ID 2851, SEQ ID 2852, SEQ ID 2866, SEQ ID 2871, SEQ ID 2872, SEQ ID 2886, SEQ ID 2887, SEQ ID 2890, SEQ ID 2891, SEQ ID 2892, SEQ ID 2895, SEQ ID 2896, SEQ ID 2899, SEQ ID 2904, SEQ ID 2910, SEQ ID 2911, SEQ ID 2912, SEQ ID 2913, SEQ ID 2914, SEQ ID 2916, SEQ ID 2918, SEQ ID 2919, SEQ ID 2920, SEQ ID 2922, SEQ ID 2925, SEQ ID 2926, SEQ ID 2932, SEQ ID 2939, SEQ ID 2941, SEQ ID 2942, SEQ ID 2943, SEQ ID 2972, SEQ ID 2973, SEQ ID 2974, SEQ ID 2975, SEQ ID 2976, SEQ ID 2977, SEQ ID 2980, SEQ ID 2983, SEQ ID 2985, SEQ ID 3053, SEQ ID 3054, SEQ ID 3055, SEQ ID 3056, SEQ ID 3058, SEQ ID 3059, SEQ ID 3060, SEQ ID 3061, SEQ ID 3062, SEQ ID 3063, SEQ ID 3064, SEQ ID 3065, SEQ ID 3066, SEQ ID 3068, SEQ ID 3069, SEQ ID 3070, SEQ ID 3071, SEQ ID 3072, SEQ ID 3073, SEQ ID 3074, SEQ ID 3075, SEQ ID 3076, SEQ ID 3077, SEQ ID 3078, SEQ ID 3079, SEQ ID 3082, SEQ ID 3083, SEQ ID 3084, SEQ ID 3085, SEQ ID 3088, SEQ ID 3089, SEQ ID 3090, SEQ ID 3091, SEQ ID 3092, SEQ ID 3095, SEQ ID 3097, SEQ ID 3102, SEQ ID 3106, SEQ ID 3108, SEQ ID 3110, SEQ ID 3116, SEQ ID 3120, SEQ ID 3121, SEQ ID 3125, SEQ ID 3126, SEQ ID 3133, SEQ ID 3134, SEQ ID 3135, SEQ ID 3137, SEQ ID 3138, SEQ ID 3140, SEQ ID 3141, SEQ ID 3142, SEQ ID 3143, SEQ ID 3145, SEQ ID 3148, SEQ ID 3152, SEQ ID 3153, SEQ ID 3156, SEQ ID 3157, SEQ ID 3158, SEQ ID 3159, SEQ ID 3160, SEQ ID 3161, SEQ ID 3162, SEQ ID 3163, SEQ ID 3164, SEQ ID 3165, SEQ ID 3166, SEQ ID 3167, SEQ ID 3168, SEQ ID 3169, SEQ ID 3170, SEQ ID 3172, SEQ ID 3173, SEQ ID 3174, SEQ ID 3175, SEQ ID 3176, SEQ ID 3177, SEQ ID 3178, SEQ ID 3179, SEQ ID 3180, SEQ ID 3181, SEQ ID 3182, SEQ ID 3183, SEQ ID 3184, SEQ ID 3186, SEQ ID 3188, SEQ ID 3191, SEQ ID 3193, SEQ ID 3196, SEQ ID 3197, SEQ ID 3203, SEQ ID 3205, SEQ ID 3206, SEQ ID 3207, SEQ ID 3210, SEQ ID 3211, SEQ ID 3212, SEQ ID 3213, SEQ ID 3214, SEQ ID 3215, SEQ ID 3216, SEQ ID 3217, SEQ ID 3218, SEQ ID 3219, SEQ ID 3221, SEQ ID 3222, SEQ ID 3223, SEQ ID 3224, SEQ ID 3227, SEQ ID 3236, SEQ ID 3237, SEQ ID 3238, SEQ ID 3239, SEQ ID 3240, SEQ ID 3241, SEQ ID 3242, SEQ ID 3243, SEQ ID 3244, SEQ ID 3245, SEQ ID 3246, SEQ ID 3248, SEQ ID 3249, SEQ ID 3250, SEQ ID 3251, SEQ ID 3252, SEQ ID 3254, SEQ ID 3258, SEQ ID 3259, SEQ ID 3261, SEQ ID 3263, SEQ ID 3265, SEQ ID 3266, SEQ ID 3267, SEQ ID 3271, SEQ ID 3272, SEQ ID 3273, SEQ ID 3276, SEQ ID 3277, SEQ ID 3279, SEQ ID 3286, SEQ ID 3295, SEQ ID 3297, SEQ ID 3305, SEQ ID 3307, SEQ ID 3309, SEQ ID 3312, SEQ ID 3313, SEQ ID 3314, SEQ ID 3316, SEQ ID 3317, SEQ ID 3318, SEQ ID 3320, SEQ ID 3332, SEQ ID 3335, SEQ ID 3336, SEQ ID 3337, SEQ ID 3338, SEQ ID 3339, SEQ ID 3340, SEQ ID 3342, SEQ ID 3343, SEQ ID 3345, SEQ ID 3346, SEQ ID 3347, SEQ ID 3348, SEQ ID 3349, SEQ ID 3350, SEQ ID 3351, SEQ ID 3352, SEQ ID 3353, SEQ ID 3354, SEQ ID 3355, SEQ ID 3356, SEQ ID 3359, SEQ ID 3360, SEQ ID 3361, SEQ ID 3362, SEQ ID 3363, SEQ ID 3364, SEQ ID 3365, SEQ ID 3366, SEQ ID 3369, SEQ ID 3370, SEQ ID 3390, SEQ ID 3392, SEQ ID 3393, SEQ ID 3394, SEQ ID 3395, SEQ ID 3396, SEQ ID 3397, SEQ ID 3398, SEQ ID 3399, SEQ ID 3401, SEQ ID 3403, SEQ ID 3404, SEQ ID 3407, SEQ ID 3408, SEQ ID 3409, SEQ ID 3410, SEQ ID 3411, SEQ ID 3412, SEQ ID 3413, SEQ ID 3414, SEQ ID 3415, SEQ ID 3417, SEQ ID 3419, SEQ ID 3420, SEQ ID 3422, SEQ ID 3423, SEQ ID 3424, SEQ ID 3428, SEQ ID 3429, SEQ ID 3430, SEQ ID 3432, SEQ ID 3433, SEQ ID 3434, SEQ ID 3435, SEQ ID 3436, SEQ ID 3437, SEQ ID 3439, SEQ ID 3440, SEQ ID 3441, SEQ ID 3442, SEQ ID 3443, SEQ ID 3444, SEQ ID 3445, SEQ ID 3446, SEQ ID 3447, SEQ ID 3448, SEQ ID 3449, SEQ ID 3450, SEQ ID 3451, SEQ ID 3452, SEQ ID 3460, SEQ ID 3461, SEQ ID 3466, SEQ ID 3467, SEQ ID 3468, SEQ ID 3490, SEQ ID 3494, SEQ ID 3496, SEQ ID 3501, SEQ ID 3505, SEQ ID 3511, SEQ ID 3512, SEQ ID 3516, SEQ ID 3517, SEQ ID 3521, SEQ ID 3522, SEQ ID 3556, SEQ ID 3557, SEQ ID 3561, SEQ ID 3566, SEQ ID 3567, SEQ ID 3568, SEQ ID 3569, SEQ ID 3571, SEQ ID 3572, SEQ ID 3576, SEQ ID 3578, SEQ ID 3580, SEQ ID 3584, SEQ ID 3594, SEQ ID 3613, SEQ ID 3614, SEQ ID 3624, SEQ ID 3625, SEQ ID 3626, SEQ ID 3627, SEQ ID 3628, SEQ ID 3633, SEQ ID 3641, SEQ ID 3643, SEQ ID 3648, SEQ ID 3651, SEQ ID 3654, SEQ ID 3656, SEQ ID 3659, SEQ ID 3660, SEQ ID 3661, SEQ ID 3670, SEQ ID 3676, SEQ ID 3680, SEQ ID 3681, SEQ ID 3683, SEQ ID 3684, SEQ ID 3685, SEQ ID 3686, SEQ ID 3687, SEQ ID 3688, SEQ ID 3689, SEQ ID 3691, SEQ ID 3693, SEQ ID 3694, SEQ ID 3695, SEQ ID 3696, SEQ ID 3698, SEQ ID 3700, SEQ ID 3701, SEQ ID 3703, SEQ ID 3704, SEQ ID 3707, SEQ ID 3708, SEQ ID 3709, SEQ ID 3710, SEQ ID 3711, SEQ ID 3712, SEQ ID 3713, SEQ ID 3714, SEQ ID 3715, SEQ ID 3716, SEQ ID 3717, SEQ ID 3718, SEQ ID 3719, SEQ ID 3720, SEQ ID 3721, SEQ ID 3722, SEQ ID 3723, SEQ ID 3725, SEQ ID 3744, SEQ ID 3747, SEQ ID 3748, SEQ ID 3749, SEQ ID 3750, SEQ ID 3751, SEQ ID 3752, SEQ ID 3753, SEQ ID 3754, SEQ ID 3755, SEQ ID 3774, SEQ ID 3775, SEQ ID 3776, SEQ ID 3786, SEQ ID 3788, SEQ ID 3790, SEQ ID 3791, SEQ ID 3793, SEQ ID 3794, SEQ ID 3795, SEQ ID 3796, SEQ ID 3797, SEQ ID 3798, SEQ ID 3799, SEQ ID 3800, SEQ ID 3801, SEQ ID 3802, SEQ ID 3803, SEQ ID 3804, SEQ ID 3805, SEQ ID 3809, SEQ ID 3810, SEQ ID 3811, SEQ ID 3812, SEQ ID 3813, SEQ ID 3814, SEQ ID 3815, SEQ ID 3821, SEQ ID 3822, SEQ ID 3823, SEQ ID 3824, SEQ ID 3825, SEQ ID 3826, SEQ ID 3827, SEQ ID 3828, SEQ ID 3830, SEQ ID 3831, SEQ ID 3832, SEQ ID 3834, SEQ ID 3836, SEQ ID 3837, SEQ ID 3838, SEQ ID 3839, SEQ ID 3840, SEQ ID 3841, SEQ ID 3842, SEQ ID 3844, SEQ ID 3850, SEQ ID 3852, SEQ ID 3867, SEQ ID 3868, SEQ ID 3870, SEQ ID 3871, SEQ ID 3872, SEQ ID 3873, SEQ ID 3874, SEQ ID 3875, SEQ ID 3876, SEQ ID 3879, SEQ ID 3880, SEQ ID 3881, SEQ ID 3882, SEQ ID 3883, SEQ ID 3884, SEQ ID 3885, SEQ ID 3886, SEQ ID 3887, SEQ ID 3888, SEQ ID 3889, SEQ ID 3890, SEQ ID 3891, SEQ ID 3892, SEQ ID 3893, SEQ ID 3894, SEQ ID 3895, SEQ ID 3896, SEQ ID 3897, SEQ ID 3908, SEQ ID 3909, SEQ ID 3910, SEQ ID 3911, SEQ ID 3912, SEQ ID 3913, SEQ ID 3922, SEQ ID 3923, SEQ ID 3930, SEQ ID 3935, SEQ ID 3936, SEQ ID 3937, SEQ ID 3938, SEQ ID 3939, SEQ ID 3940, SEQ ID 3944, SEQ ID 3945, SEQ ID 3946, SEQ ID 3947, and SEQ ID 3948.

In some embodiments the oligonucleotide comprises the contiguous nucleotide sequence, and may optionally comprise further nucleotide(s), for example a nucleotide linker region which may be used to attach a functional group (e.g. a conjugate group) to the contiguous nucleotide sequence. The nucleotide linker region may or may not be complementary to the target nucleic acid. It is understood that the contiguous nucleotide sequence of the oligonucleotide cannot be longer than the oligonucleotide as such and that the oligonucleotide cannot be shorter than the contiguous nucleotide sequence.

Nucleotides and Nucleosides

Nucleotides and nucleosides are the building blocks of oligonucleotides and polynucleotides, and for the purposes of the present invention include both naturally occurring and non-naturally occurring nucleotides and nucleosides. In nature, nucleotides, such as DNA and RNA nucleotides comprise a ribose sugar moiety, a nucleobase moiety and one or more phosphate groups (which is absent in nucleosides). Nucleosides and nucleotides may also interchangeably be referred to as “units” or “monomers”.

Modified Nucleoside

Advantageously, the antisense oligonucleotide progranulin agonist of the invention may comprise one or more modified nucleoside.

The term “modified nucleoside” or “nucleoside modification” as used herein refers to nucleosides modified as compared to the equivalent DNA or RNA nucleoside by the introduction of one or more modifications of the sugar moiety or the (nucleo) base moiety. Advantageously, one or more of the modified nucleosides of the antisense oligonucleotides of the invention may comprise a modified sugar moiety. The term modified nucleoside may also be used herein interchangeably with the term “nucleoside analogue” or modified “units” or modified “monomers”. Nucleosides with an unmodified DNA or RNA sugar moiety are termed DNA or RNA nucleosides herein. Nucleosides with modifications in the base region of the DNA or RNA nucleoside are still generally termed DNA or RNA if they allow Watson Crick base pairing. Exemplary modified nucleosides which may be used in the antisense oligonucleotide progranulin agonists of the invention include LNA, 2′-O-MOE, 2′oMe and morpholino nucleoside analogues.

Modified Internucleoside Linkage

Advantageously, the antisense oligonucleotide progranulin agonist of the invention comprises one or more modified internucleoside linkage.

The term “modified internucleoside linkage” is defined as generally understood by the skilled person as linkages other than phosphodiester (PO) linkages, that covalently couple two nucleosides together. The antisense oligonucleotide progranulin agonists of the invention may therefore comprise one or more modified internucleoside linkages such as one or more phosphorothioate internucleoside linkage.

In some embodiments at least 50% of the internucleoside linkages in the antisense oligonucleotide progranulin agonist, or contiguous nucleotide sequence thereof, are phosphorothioate, such as at least 60%, such as at least 70%, such as at least 75%, such as at least 80%, such as at least 90% or more of the internucleoside linkages in the antisense oligonucleotide progranulin agonist, or contiguous nucleotide sequence thereof, are phosphorothioate. In some embodiments all of the internucleoside linkages of the antisense oligonucleotide progranulin agonist, or contiguous nucleotide sequence thereof, are phosphorothioate.

Advantageously, all the internucleoside linkages of the contiguous nucleotide sequence of the antisense oligonucleotide progranulin agonist may be phosphorothioate, or all the internucleoside linkages of the antisense oligonucleotide progranulin agonist may be phosphorothioate linkages.

Nucleobase

The term nucleobase includes the purine (e.g. adenine and guanine) and pyrimidine (e.g. uracil, thymine and cytosine) moiety present in nucleosides and nucleotides which form hydrogen bonds in nucleic acid hybridization. In the context of the present invention the term nucleobase also encompasses modified nucleobases which may differ from naturally occurring nucleobases, but which are functional during nucleic acid hybridization. In this context “nucleobase” refers to both naturally occurring nucleobases such as adenine, guanine, cytosine, thymidine, uracil, xanthine and hypoxanthine, as well as non-naturally occurring variants. Such variants are for example described in Hirao et al (2012) Accounts of Chemical Research vol 45 page 2055 and Bergstrom (2009) Current Protocols in Nucleic Acid Chemistry Suppl. 37 1.4.1.

In some embodiments the nucleobase moiety is modified by changing the purine or pyrimidine into a modified purine or pyrimidine, such as substituted purine or substituted pyrimidine, such as a nucleobase selected from isocytosine, pseudoisocytosine, 5-methyl cytosine, 5-thiozolo-cytosine, 5-propynyl-cytosine, 5-propynyl-uracil, 5-bromouracil 5-thiazolo-uracil, 2-thio-uracil, 2′thio-thymine, inosine, diaminopurine, 6-aminopurine, 2-aminopurine, 2,6-diaminopurine and 2-chloro-6-aminopurine.

The nucleobase moieties may be indicated by the letter code for each corresponding nucleobase, e.g. A, T, G, C or U, wherein each letter may optionally include modified nucleobases of equivalent function. For example, in the exemplified oligonucleotides, the nucleobase moieties are selected from A, T, G, C, and 5-methyl cytosine. Optionally, for LNA gapmers, 5-methyl cytosine LNA nucleosides may be used.

Modified Oligonucleotide

The antisense oligonucleotide progranulin agonist of the invention may be a modified oligonucleotide.

The term modified oligonucleotide describes an oligonucleotide comprising one or more sugar-modified nucleosides and/or modified internucleoside linkages. The term “chimeric oligonucleotide” is a term that has been used in the literature to describe oligonucleotides comprising sugar modified nucleosides and DNA nucleosides. In some embodiments, it may be advantageous for the antisense oligonucleotide progranulin agonist of the invention to be a chimeric oligonucleotide.

Complementarity

The term “complementarity” describes the capacity for Watson-Crick base-pairing of nucleosides/nucleotides. Watson-Crick base pairs are guanine (G)-cytosine (C) and adenine (A)-thymine (T)/uracil (U).

It will be understood that oligonucleotides may comprise nucleosides with modified nucleobases, for example 5-methyl cytosine is often used in place of cytosine, and as such the term complementarity encompasses Watson Crick base-paring between non-modified and modified nucleobases (see for example Hirao et al (2012) Accounts of Chemical Research vol 45 page 2055 and Bergstrom (2009) Current Protocols in Nucleic Acid Chemistry Suppl. 37 1.4.1).

The term “% complementary” as used herein, refers to the proportion of nucleotides (in percent) of a contiguous nucleotide sequence in a nucleic acid molecule (e.g. oligonucleotide) which across the contiguous nucleotide sequence, are complementary to a reference sequence (e.g. a target sequence or sequence motif). The percentage of complementarity is thus calculated by counting the number of aligned nucleobases that are complementary (from Watson Crick base pairs) between the two sequences (when aligned with the target sequence 5′-3′ and the oligonucleotide sequence from 3′-5′), dividing that number by the total number of nucleotides in the oligonucleotide and multiplying by 100. In such a comparison a nucleobase/nucleotide which does not align (form a base pair) is termed a mismatch. Insertions and deletions are not allowed in the calculation of % complementarity of a contiguous nucleotide sequence. It will be understood that in determining complementarity, chemical modifications of the nucleobases are disregarded as long as the functional capacity of the nucleobase to form Watson Crick base pairing is retained (e.g. 5′-methyl cytosine is considered identical to a cytosine for the purpose of calculating % identity).

Within the present invention the term “complementary” requires the antisense oligonucleotide progranulin agonist to be at least about 80% complementary, or at least about 90% complementary, to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript. In some embodiments the antisense oligonucleotide progranulin agonist may be at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98% or at least about 99% complementary to a human progranulin precursor-mRNA (pre-mRNA) or mature mRNA transcript. Put another way, for some embodiments, an antisense oligonucleotide progranulin agonist of the invention may include one, two, three or more mis-matches, wherein a mis-match is a nucleotide within the antisense oligonucleotide progranulin agonist of the invention which does not base pair with its target.

The term “fully complementary”, refers to 100% complementarity.

The antisense oligonucleotide progranulin agonists of the invention are advantageously complementary to the human progranulin precursor mRNA (pre-mRNA) or the human progranulin mature mRNA sequence. The human progranulin mature mRNA sequence is exemplified herein as SEQ ID NO 1. The human progranulin precursor-mRNA (pre-mRNA) sequence is exemplified herein as SEQ ID NO 3949. SEQ ID NO 1 and SEQ ID NO 3949 are provided herein as reference sequences and it will be understood that the target progranulin nucleic acid may be an allelic variant of SEQ ID NO 1 or SEQ ID NO 3949, such as an allelic variant which comprises one or more polymorphism in the human progranulin nucleic acid sequence.

Identity

The term “identity” as used herein, refers to the proportion of nucleotides (expressed in percent) of a contiguous nucleotide sequence in a nucleic acid molecule (e.g. oligonucleotide) which across the contiguous nucleotide sequence, are identical to a reference sequence (e.g. a sequence motif).

The percentage of identity is thus calculated by counting the number of aligned nucleobases that are identical (a Match) between two sequences (in the contiguous nucleotide sequence of the compound of the invention and in the reference sequence), dividing that number by the total number of nucleotides in the oligonucleotide and multiplying by 100. Therefore, Percentage of Identity=(Matches×100)/Length of aligned region (e.g. the contiguous nucleotide sequence). Insertions and deletions are not allowed in the calculation the percentage of identity of a contiguous nucleotide sequence. It will be understood that in determining identity, chemical modifications of the nucleobases are disregarded as long as the functional capacity of the nucleobase to form Watson Crick base pairing is retained (e.g. 5-methyl cytosine is considered identical to a cytosine for the purpose of calculating % identity).

Hybridization

The terms “hybridizing” or “hybridizes” as used herein are to be understood as two nucleic acid strands (e.g. an oligonucleotide and a target nucleic acid) forming hydrogen bonds between base pairs on opposite strands thereby forming a duplex. The affinity of the binding between two nucleic acid strands is the strength of the hybridization. It is often described in terms of the melting temperature (T_m) defined as the temperature at which half of the oligonucleotides are duplexed with the target nucleic acid. At physiological conditions T_mis not strictly proportional to the affinity (Mergny and Lacroix, 2003, Oligonucleotides 13:515-537). The standard state Gibbs free energy ΔG° is a more accurate representation of binding affinity and is related to the dissociation constant (K_d) of the reaction by ΔG°=−RTIn(K_d), where R is the gas constant and T is the absolute temperature. Therefore, a very low ΔG° of the reaction between an oligonucleotide and the target nucleic acid reflects a strong hybridization between the oligonucleotide and target nucleic acid. ΔG° is the energy associated with a reaction where aqueous concentrations are 1M, the pH is 7, and the temperature is 37° C. The hybridization of oligonucleotides to a target nucleic acid is a spontaneous reaction and for spontaneous reactions ΔG° is less than zero. ΔG° can be measured experimentally, for example, by use of the isothermal titration calorimetry (ITC) method as described in Hansen et al., 1965, Chem. Comm. 36-38 and Holdgate et al., 2005, Drug Discov Today. The skilled person will know that commercial equipment is available for ΔG° measurements. ΔG° can also be estimated numerically by using the nearest neighbor model as described by SantaLucia, 1998, Proc Natl Acad Sci USA. 95:1460-1465 using appropriately derived thermodynamic parameters described by Sugimoto et al., 1995, Biochemistry 34:11211-11216 and McTigue et al., 2004, Biochemistry 43:5388-5405.

In some embodiments, antisense oligonucleotide progranulin agonists of the present invention hybridize to a target nucleic acid with estimated ΔG° values below −10 kcal for oligonucleotides that are 10-30 nucleotides in length.

In some embodiments the degree or strength of hybridization is measured by the standard state Gibbs free energy ΔG°. The oligonucleotides may hybridize to a target nucleic acid with estimated ΔG° values below the range of −10 kcal, such as below −15 kcal, such as below −20 kcal and such as below −25 kcal for oligonucleotides that are 8-30 nucleotides in length. In some embodiments the oligonucleotides hybridize to a target nucleic acid with an estimated ΔG° value of −10 to −60 kcal, such as −12 to −40, such as from −15 to −30 kcal, or −16 to −27 kcal such as −18 to −25 kcal.

High Affinity Modified Nucleosides

A high affinity modified nucleoside is a modified nucleotide which, when incorporated into the oligonucleotide enhances the affinity of the oligonucleotide for its complementary target, for example as measured by the melting temperature (T^m). A high affinity modified nucleoside of the present invention preferably results in an increase in melting temperature between +0.5 to +12° C., more preferably between +1.5 to +10° C. and most preferably between +3 to +8° C. per modified nucleoside. Numerous high affinity modified nucleosides are known in the art and include for example, many 2′ substituted nucleosides as well as locked nucleic acids (LNA) (see e.g. Freier & Altmann; Nucl. Acid Res., 1997, 25, 4429-4443 and Uhlmann; Curr. Opinion in Drug Development, 2000, 3 (2), 293-213).

Sugar Modifications

The antisense oligonucleotide progranulin agonist of the invention may comprise one or more nucleosides which have a modified sugar moiety, i.e. a modification of the sugar moiety when compared to the ribose sugar moiety found in DNA and RNA.

Numerous nucleosides with modification of the ribose sugar moiety have been made, primarily with the aim of improving certain properties of oligonucleotides, such as affinity and/or nuclease resistance.

Such modifications include those where the ribose ring structure is modified, e.g. by replacement with a hexose ring (HNA), or a bicyclic ring, which typically have a biradicle bridge between the C2 and C4 carbons on the ribose ring (LNA), or an unlinked ribose ring which typically lacks a bond between the C2 and C3 carbons (e.g. UNA). Other sugar modified nucleosides include, for example, bicyclohexose nucleic acids (WO2011/017521) or tricyclic nucleic acids (WO2013/154798). Modified nucleosides also include nucleosides where the sugar moiety is replaced with a non-sugar moiety, for example in the case of peptide nucleic acids (PNA), or morpholino nucleic acids.

Sugar modifications also include modifications made via altering the substituent groups on the ribose ring to groups other than hydrogen, or the 2′-OH group naturally found in DNA and RNA nucleosides. Substituents may, for example be introduced at the 2′, 3′, 4′ or 5′ positions.

2′ Sugar Modified Nucleosides

A 2′ sugar modified nucleoside is a nucleoside which has a substituent other than H or -OH at the 2′ position (2′ substituted nucleoside) or comprises a 2′ linked biradicle capable of forming a bridge between the 2′ carbon and a second carbon in the ribose ring, such as LNA (2′-4′ biradicle bridged) nucleosides.

Indeed, much focus has been spent on developing 2′ sugar substituted nucleosides, and numerous 2′ substituted nucleosides have been found to have beneficial properties when incorporated into oligonucleotides. For example, the 2′ modified sugar may provide enhanced binding affinity and/or increased nuclease resistance to the oligonucleotide. Examples of 2′ substituted modified nucleosides are 2′-O-alkyl-RNA, 2′-O-methyl-RNA (2′oMe), 2′-alkoxy-RNA, 2′-O-methoxyethyl-RNA (MOE), 2′-amino-DNA, 2′-Fluoro-RNA, and 2′-F-ANA nucleoside. For further examples, please see e.g. Freier & Altmann; Nucl. Acid Res., 1997, 25, 4429-4443 and Uhlmann; Curr. Opinion in Drug Development, 2000, 3 (2), 293-213, and Deleavey and Damha, Chemistry and Biology 2012, 19, 937. Below are illustrations of some 2′ substituted modified nucleosides.

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In relation to the present invention 2′ substituted sugar modified nucleosides does not include 2′ bridged nucleosides like LNA.

Locked Nucleic Acid Nucleosides (LNA Nucleoside)

A “LNA nucleoside” is a 2′-modified nucleoside which comprises a biradical linking the C2′ and C4′ of the ribose sugar ring of said nucleoside (also referred to as a “2′-4′ bridge”), which restricts or locks the conformation of the ribose ring. These nucleosides are also termed bridged nucleic acid or bicyclic nucleic acid (BNA) in the literature. The locking of the conformation of the ribose is associated with an enhanced affinity of hybridization (duplex stabilization) when the LNA is incorporated into an oligonucleotide for a complementary RNA or DNA molecule. This can be routinely determined by measuring the melting temperature of the oligonucleotide/complement duplex.

Non limiting, exemplary LNA nucleosides are disclosed in WO 99/014226, WO 00/66604, WO 98/039352, WO 2004/046160, WO 00/047599, WO 2007/134181, WO 2010/077578, WO 2010/036698, WO 2007/090071, WO 2009/006478, WO 2011/156202, WO 2008/154401, WO 2009/067647, WO 2008/150729, Morita et al., Bioorganic & Med. Chem. Lett. 12, 73-76, Seth et al. J. Org. Chem. 2010, Vol 75 (5) pp. 1569-81, and Mitsuoka et al., Nucleic Acids Research 2009, 37 (4), 1225-1238, and Wan and Seth, J. Medical Chemistry 2016, 59, 9645-9667.

Further non limiting, exemplary LNA nucleosides are disclosed in Scheme 1.

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Particular LNA nucleosides are beta-D-oxy-LNA, 6′-methyl-beta-D-oxy LNA such as(S)-6′-methyl-beta-D-oxy-LNA (ScET) and ENA.

A particularly advantageous LNA is beta-D-oxy-LNA.

Morpholino Oligonucleotides

In some embodiments, the antisense oligonucleotide progranulin agonist of the invention comprises or consists of morpholino nucleosides (i.e. is a Morpholino oligomer and as a phosphorodiamidate Morpholino oligomer (PMO)). Splice modulating morpholino oligonucleotides have been approved for clinical use—see for example eteplirsen, a 30 nt morpholino oligonucleotide targeting a frame shift mutation in DMD, used to treat Duchenne muscular dystrophy. Morpholino oligonucleotides have nucleobases attached to six membered morpholine rings rather ribose, such as methylenemorpholine rings linked through phosphorodiamidate groups, for example as illustrated by the following illustration of 4 consecutive morpholino nucleotides:

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In some embodiments, morpholino oligonucleotides of the invention may be, for example 20-40 morpholino nucleotides in length, such as morpholino 25-35 nucleotides in length.

Rnase H Activity and Recruitment

The RNase H activity of an antisense oligonucleotide refers to its ability to recruit RNase H when in a duplex with a complementary RNA molecule. WO01/23613 provides in vitro methods for determining RNaseH activity, which may be used to determine the ability to recruit RNaseH. Typically an oligonucleotide is deemed capable of recruiting RNase H if it, when provided with a complementary target nucleic acid sequence, has an initial rate, as measured in pmol/l/min, of at least 5%, such as at least 10%, at least 20% or more than 20%, of the initial rate determined when using an oligonucleotide having the same base sequence as the modified oligonucleotide being tested, but containing only DNA monomers with phosphorothioate linkages between all monomers in the oligonucleotide, and using the methodology provided by Examples 91-95 of WO01/23613 (hereby incorporated by reference). For use in determining RHase H activity, recombinant RNase H1 is available from Lubio Science GmbH, Lucerne, Switzerland.

DNA oligonucleotides are known to effectively recruit RNaseH, as are gapmer oligonucleotides which comprise a region of DNA nucleosides (typically at least 5 or 6 contiguous DNA nucleosides), flanked 5′ and 3′ by regions comprising 2′ sugar modified nucleosides, typically high affinity 2′ sugar modified nucleosides, such as 2-O-MOE and/or LNA. For effective modulation of splicing, degradation of the pre-mRNA is not desirable, and as such it is preferable to avoid the RNaseH degradation of the target. Therefore, the antisense oligonucleotide progranulin agonists of the invention are not RNaseH recruiting gapmer oligonucleotide.

RNaseH recruitment may be avoided by limiting the number of contiguous DNA nucleotides in the oligonucleotide—therefore mixes and totalmer designs may be used. Advantageously the antisense oligonucleotide progranulin agonist of the invention, or the contiguous nucleotide sequence thereof, do not comprise more than 3 contiguous DNA nucleosides. Further, advantageously the antisense oligonucleotide progranulin agonists of the invention, or the contiguous nucleotide sequence thereof, do not comprise more than 4 contiguous DNA nucleosides. Further advantageously, the progranulin agonist antisense oligonucleotide agonists of the invention, or contiguous nucleotide sequence thereof, do not comprise more than 2 contiguous DNA nucleosides.

Mixmers and Totalmers

For splice modulation it is often advantageous to use antisense oligonucleotides which do not recruit RNAaseH. As RNaseH activity requires a contiguous sequence of DNA nucleotides, RNaseH activity of antisense oligonucleotide may be achieved by designing antisense oligonucleotides which do not comprise a region of more than 3 or more than 4 contiguous DNA nucleosides. This may be achieved by using antisense oligonucleotides or contiguous nucleoside regions thereof with a mixmer design, which comprise sugar modified nucleosides, such as 2′ sugar modified nucleosides, and short regions of DNA nucleosides, such as 1, 2 or 3 DNA nucleosides. Mixmers are exemplified herein by every second design, wherein the nucleosides alternate between 1 LNA and 1 DNA nucleoside, e.g. LDLDLDLDLDLDLDLL, with 5′ and 3′ terminal LNA nucleosides, and every third design, such as LDDLDDLDDLDDLDDL, where every third nucleoside is a LNA nucleoside.

A totalmer is an antisense oligonucleotide or a contiguous nucleotide sequence thereof which does not comprise DNA or RNA nucleosides, and may for example comprise only 2′-O-MOE nucleosides, such as a fully MOE phosphorothioate, e.g. MMMMMMMMMMMMMMMMMMMM, where M=2′-O-MOE, or may for example comprise only 2′oMe nucleosides, which are reported to be effective splice modulators for therapeutic use.

Alternatively, a mixmer may comprise a mixture of modified nucleosides, such as MLMLMLMLMLMLMLMLMLML, wherein L=LNA and M=2′-O-MOE nucleosides. Advantageously, the internucleoside nucleosides in mixmers and totalmers may be phosphorothioate, or a majority of nucleoside linkages in mixmers may be phosphorothioate. Mixmers and totalmers may comprise other internucleoside linkages, such as phosphodiester or phosphorodithioate, by way of example.

Region D′ or D″ in an Oligonucleotide

The antisense oligonucleotide progranulin agonist of the invention may in some embodiments comprise or consist of the contiguous nucleotide sequence of the oligonucleotide which is complementary to the target nucleic acid, such as a mixmer or totalmer region, and further 5′ and/or 3′ nucleosides. The further 5′ and/or 3′ nucleosides may or may not be complementary, such as fully complementary, to the target nucleic acid. Such further 5′ and/or 3′ nucleosides may be referred to as region D′ and D″ herein.

The addition of region D′ or D″ may be used for the purpose of joining the contiguous nucleotide sequence, such as the mixmer or totalmer, to a conjugate moiety or another functional group. When used for joining the contiguous nucleotide sequence with a conjugate moiety is can serve as a biocleavable linker. Alternatively, it may be used to provide exonuclease protection or for ease of synthesis or manufacture.

Region D′ or D″ may independently comprise or consist of 1, 2, 3, 4 or 5 additional nucleotides, which may be complementary or non-complementary to the target nucleic acid. The nucleotide adjacent to the F or F′ region is not a sugar-modified nucleotide, such as a DNA or RNA or base modified versions of these. The D′ or D′ region may serve as a nuclease susceptible biocleavable linker (see definition of linkers). In some embodiments the additional 5′ and/or 3′ end nucleotides are linked with phosphodiester linkages, and are DNA or RNA. Nucleotide based biocleavable linkers suitable for use as region D′ or D″ are disclosed in WO2014/076195, which include by way of example a phosphodiester linked DNA dinucleotide. The use of biocleavable linkers in poly-oligonucleotide constructs is disclosed in WO2015/113922, where they are used to link multiple antisense constructs within a single oligonucleotide.

In one embodiment the antisense oligonucleotide progranulin agonist of the invention comprises a region D′ and/or D″ in addition to the contiguous nucleotide sequence which constitutes a mixmer or a totalmer.

In some embodiments the internucleoside linkage positioned between region D′ or D″ and the mixmer or totalmer region is a phosphodiester linkage.

Conjugate

The invention encompasses an antisense oligonucleotide progranulin agonist covalently attached to at least one conjugate moiety. In some embodiments this may be referred to as a conjugate of the invention.

The term “conjugate” as used herein refers to an antisense oligonucleotide progranulin agonist which is covalently linked to a non-nucleotide moiety (conjugate moiety or region C or third region). The conjugate moiety may be covalently linked to the antisense oligonucleotide, optionally via a linker group, such as region D′ or D″.

Oligonucleotide conjugates and their synthesis has also been reported in comprehensive reviews by Manoharan in Antisense Drug Technology, Principles, Strategies, and Applications, S. T. Crooke, ed., Ch. 16, Marcel Dekker, Inc., 2001 and Manoharan, Antisense and Nucleic Acid Drug Development, 2002, 12, 103.

In some embodiments, the non-nucleotide moiety (conjugate moiety) is selected from the group consisting of carbohydrates (e.g. GalNAc), cell surface receptor ligands, drug substances, hormones, lipophilic substances, polymers, proteins, peptides, toxins (e.g. bacterial toxins), vitamins, viral proteins (e.g. capsids) or combinations thereof.

Linkers

A linkage or linker is a connection between two atoms that links one chemical group or segment of interest to another chemical group or segment of interest via one or more covalent bonds. Conjugate moieties can be attached to the antisense oligonucleotide progranulin agonist directly or through a linking moiety (e.g. linker or tether). Linkers serve to covalently connect a third region, e.g. a conjugate moiety (Region C), to a first region, e.g. an oligonucleotide or contiguous nucleotide sequence complementary to the target nucleic acid (region A).

In some embodiments of the invention the conjugate or antisense oligonucleotide progranulin agonist conjugate of the invention may optionally comprise a linker region (second region or region B and/or region Y) which is positioned between the oligonucleotide or contiguous nucleotide sequence complementary to the target nucleic acid (region A or first region) and the conjugate moiety (region C or third region).

Region B refers to biocleavable linkers comprising or consisting of a physiologically labile bond that is cleavable under conditions normally encountered or analogous to those encountered within a mammalian body. Conditions under which physiologically labile linkers undergo chemical transformation (e.g., cleavage) include chemical conditions such as pH, temperature, oxidative or reductive conditions or agents, and salt concentration found in or analogous to those encountered in mammalian cells. Mammalian intracellular conditions also include the presence of enzymatic activity normally present in a mammalian cell such as from proteolytic enzymes or hydrolytic enzymes or nucleases. In one embodiment the biocleavable linker is susceptible to S1 nuclease cleavage. In some embodiments the nuclease susceptible linker comprises between 1 and 5 nucleosides, such as DNA nucleoside(s) comprising at least two consecutive phosphodiester linkages. Phosphodiester containing biocleavable linkers are described in more detail in WO 2014/076195.

Region Y refers to linkers that are not necessarily biocleavable but primarily serve to covalently connect a conjugate moiety (region C or third region), to an oligonucleotide (region A or first region). The region Y linkers may comprise a chain structure or an oligomer of repeating units such as ethylene glycol, amino acid units or amino alkyl groups The antisense oligonucleotide progranulin agonist conjugates of the present invention can be constructed of the following regional elements A-C, A-B-C, A-B-Y-C, A-Y-B-C or A-Y-C. In some embodiments the linker (region Y) is an amino alkyl, such as a C2-C36 amino alkyl group, including, for example C6 to C12 amino alkyl groups. In some embodiments the linker (region Y) is a C6 amino alkyl group.

Treatment

The term ‘treatment’ as used herein refers to both treatment of an existing disease (e.g. a disease or disorder as herein referred to), or prevention of a disease, i.e. prophylaxis. It will therefore be recognized that treatment as referred to herein may, in some embodiments, be prophylactic.

DETAILED DESCRIPTION OF THE INVENTION

The inventors have identified that the expression level of the progranulin transcript can be effectively enhanced by targeting the progranulin precursor-mRNA (pre-mRNA) transcript or the progranulin mature mRNA sequence with antisense oligonucleotides, particularly antisense oligonucleotides which comprise high affinity sugar modified nucleosides, such as high affinity 2′ sugar modified nucleosides, such as LNA nucleosides or 2′-O-methoxyethyl (MOE) nucleosides.

Described herein are target sites present on the human progranulin nucleic acid target, such as a progranulin precursor-mRNA (pre-mRNA) or mature mRNA sequence, which can be targeted by antisense oligonucleotide agonists of progranulin.

The inventors have surprisingly determined that targeting the 5′ UTR and 3′ UTR of the progranulin mature mRNA can be particularly effective.

The 5′ UTR contains upstream start sites (AUG sites), also known as upstream open reading frames (uORFs). Without wishing to be bound by theory, it is considered that the antisense oligonucleotide progranulin agonists of the invention can increase progranulin production by binding to these regions and affecting, such as reducing, protein translation from these upstream AUG sites. This ensures that protein translation is initiated from the downstream canonical start site (ORF), increasing progranulin production.

The 3′ UTR contains binding sites for microRNAs. Without wishing to be bound by theory, it is considered that the antisense oligonucleotide progranulin agonists of the invention may regulate gene expression by binding to these sites in the 3′UTR and preventing microRNA-induced repression of gene expression, leading to increased progranulin production.

Oligonucleotides, such as RNaseH recruiting single stranded antisense oligonucleotides or siRNAs are used extensively in the art to inhibit target RNAs—i.e. are used as antagonists of their complementary nucleic acid target.

The antisense oligonucleotide of the present invention are agonists, i.e. enhance the expression of their complementary target, progranulin nucleic acids, and thereby enhance the expression of progranulin protein. Enhanced progranulin expression is desirable to treat a range of neurological disorders, such as TDP-43 pathologies, or disorders which are characterized by, or caused by progranulin haploinsufficiency.

In certain embodiments the antisense oligonucleotide progranulin agonists of the present invention may enhance the production of their complementary target, progranulin nucleic acids, by at least about 10%. In other embodiments the antisense oligonucleotide progranulin agonists of the present invention may enhance the production of their complementary target, progranulin nucleic acids, by at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50% or more, at least about 60% or more, at least about 70% or more, at least about 80% or more, at least about 90% or more, at least about 100% or more, at least about 200% or more, at least about 300% or more, at least about 400% or more, or at least about 500% or more.

In some embodiments, the antisense oligonucleotide progranulin agonist of the invention or the contiguous nucleotide sequence thereof comprises or consists of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 or 40 contiguous nucleotides in length.

In some embodiments, the entire nucleotide sequence of the antisense oligonucleotide is the contiguous nucleotide sequence.

In some embodiments the contiguous nucleotide sequence is complementary to a 5′UTR region of a human progranulin mature mRNA transcript. The contiguous nucleotide sequence may be fully complementary to a 5′UTR region of a human progranulin mature mRNA transcript. As indicated above, and without wishing to be bound by theory, targeting the 5′UTR may increase progranulin expression by binding to upstream start sites (AUG sites) and affecting, such as reducing, protein translation from these upstream AUG sites. This ensures that protein translation is initiated from the downstream canonical start site (ORF), increasing progranulin production.

In some embodiments the contiguous nucleotide sequence may be complementary to SEQ ID NO 2, SEQ ID NO 689, SEQ ID NO 683, SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, SEQ ID NO 688, or a sequence selected from the group consisting of SEQ ID NO 343-586.

In another embodiment the contiguous nucleotide sequence may be complementary to nucleotides 38-246 of SEQ ID NO 1.

In another embodiment the contiguous nucleotide sequence may be fully complementary to SEQ ID NO 2, or SEQ ID NO 689.

In another embodiment the contiguous nucleotide sequence may be fully complementary to a sequence selected from the group consisting of SEQ ID NO 568, SEQ ID NO 571, SEQ ID NO 575, SEQ ID NO 576, SEQ ID NO 577, SEQ ID NO 578, SEQ ID NO 584 & SEQ ID NO 586.

In one embodiment the contiguous nucleotide sequence may a sequence selected from the group consisting of SEQ ID NO 3-342. The invention also contemplates fragments of these contiguous nucleotide sequences, including fragments of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 or at least 17 contiguous nucleotides thereof.

In certain embodiments the contiguous nucleotide sequence may be selected from the group consisting of SEQ ID NO 105, SEQ ID NO 106, SEQ ID NO 110, SEQ ID NO 113, SEQ ID NO 114, SEQ ID NO 231 and SEQ ID NO 241. The invention also contemplates fragments of these contiguous nucleotide sequences, including fragments of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16 or at least 17 contiguous nucleotides thereof.

In some embodiments the contiguous nucleotide sequence is complementary to a 3′UTR region of a human progranulin mature mRNA transcript. The contiguous nucleotide sequence may be fully complementary to a 3′UTR region of a human progranulin mature mRNA transcript. As indicated above, and without wishing to be bound by theory, the antisense oligonucleotide progranulin agonists of the invention may regulate gene expression by binding to microRNA sites in the 3′UTR and preventing microRNA-induced repression of gene expression, leading to increased progranulin production.

In some embodiments the contiguous nucleotide sequence may be complementary to SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, SEQ ID NO 688, or a sequence selected from the group consisting of SEQ ID NO 587-682.

In another embodiment the contiguous nucleotide sequence may be complementary to nucleotides 2039-2346 of SEQ ID NO 1.

In another embodiment the contiguous nucleotide sequence may be fully complementary to SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, and SEQ ID NO 688.

In another embodiment the contiguous nucleotide sequence may be fully complementary to a sequence selected from the group consisting of SEQ ID NOs 607, SEQ ID NO 608, SEQ ID NO 609, SEQ ID NO 610, SEQ ID NO 611, SEQ ID NO 612, SEQ ID NO 619, SEQ ID NO 620, SEQ ID NO 633, SEQ ID NO 640, SEQ ID NO 641, SEQ ID NO 645, SEQ ID NO 651, and SEQ ID NO 652.

In some embodiments, the antisense oligonucleotide progranulin agonist or contiguous nucleotide sequence comprises or consists of a sequence selected from the group consisting of sequences SEQ ID NO 3-342. It will be understood that the sequences shown in SEQ ID NO 3-342 may include modified nucleobases which function as the shown nucleobase in base pairing, for example 5-methyl cytosine may be used in place of methyl cytosine. Inosine may be used as a universal base.

In some embodiments, the antisense oligonucleotide progranulin agonist or contiguous nucleotide sequence comprises or consists of 8 to 30 or 8 to 40 nucleotides in length with at least 90% identity, preferably 100% identity, to a sequence selected from the group consisting of SEQ ID NO: 3 to 342. In some embodiments the antisense oligonucleotide progranulin agonist may be 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 or 40 nucleotides in length.

Without wishing to be bound by theory, it is considered that the antisense oligonucleotide progranulin agonists of the invention which bind to target sites outside the 5′ UTR and 3′ UTR regions of the progranulin mature mRNA may increase progranulin protein expression. This increased progranulin protein expression may occur as a result of effects of the antisense oligonucleotide progranulin agonists on secondary regulatory mRNA structures and/or on binding of RNA binding proteins that would otherwise negatively affect protein translation or progranulin mRNA stability.

It is understood that the contiguous nucleobase sequences (motif sequence) can be modified to for example increase nuclease resistance and/or binding affinity to the target nucleic acid.

The pattern in which the modified nucleosides (such as high affinity modified nucleosides) are incorporated into the oligonucleotide sequence is generally termed oligonucleotide design.

The antisense oligonucleotide progranulin agonists of the invention are designed with modified nucleosides and DNA nucleosides. Advantageously, high affinity modified nucleosides are used.

In an embodiment, the oligonucleotide comprises at least 1 modified nucleoside, such as at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15 or at least 16 modified nucleosides.

In an embodiment the oligonucleotide comprises from 1 to 10 modified nucleosides, such as from 2 to 9 modified nucleosides, such as from 3 to 8 modified nucleosides, such as from 4 to 7 modified nucleosides, such as 6 or 7 modified nucleosides. Suitable modifications are described in the “Definitions” section under “modified nucleoside”, “high affinity modified nucleosides”, “sugar modifications”, “2′ sugar modifications” and Locked nucleic acids (LNA)”.

In an embodiment, the antisense oligonucleotide progranulin agonist comprises one or more sugar modified nucleosides, such as 2′ sugar modified nucleosides. Preferably the antisense oligonucleotide progranulin agonist of the invention comprises one or more 2′ sugar modified nucleoside independently selected from the group consisting of 2′-O-alkyl-RNA, 2′-O-methyl-RNA (2′oMe), 2′-alkoxy-RNA, 2′-O-methoxyethyl-RNA (2′MOE), 2′-amino-DNA, 2′-fluoro-DNA, arabino nucleic acid (ANA), 2′-fluoro-ANA and LNA nucleosides. It is advantageous if one or more of the modified nucleoside(s) is a locked nucleic acid (LNA).

In a further embodiment the antisense oligonucleotide progranulin agonist comprises at least one modified internucleoside linkage. Suitable internucleoside modifications are described in the “Definitions” section under “Modified internucleoside linkage”. It is advantageous if at least 75%, such as all, the internucleoside linkages within the contiguous nucleotide sequence are phosphorothioate or boranophosphate internucleoside linkages. In some embodiments all the internucleotide linkages in the contiguous sequence of the oligonucleotide are phosphorothioate linkages.

An antisense oligonucleotide progranulin agonist may have the structure:

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Numbered Paragraphs of the Invention

Aspects of the present invention will now be described by way of numbered paragraphs.

1. An antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 8-40 nucleotides in length and comprises a contiguous nucleotide sequence of 8-40 nucleotides in length which are fully complementary to a human progranulin pre-mRNA or mRNA transcript, such as SEQ ID NO 1.

2. The antisense oligonucleotide according to paragraph 1, wherein the contiguous nucleotide sequence is of a length of at least 12 nucleotides in length, such as 12-16 or 12-18 nucleotides in length.

3. The antisense oligonucleotide according to paragraph 1 or 2, wherein the contiguous nucleotide sequence is the same length as the antisense oligonucleotide.

4. The antisense oligonucleotide according to any one of paragraphs 1-3, wherein contiguous nucleotide sequence is fully complementary to SEQ ID NO 2, SEQ ID NO 689, SEQ ID NO 683, SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, SEQ ID NO 688, or a sequence selected from the group consisting of SEQ ID NO 343-682.

5. The antisense oligonucleotide according to any one of paragraphs 1-4, wherein contiguous nucleotide sequence is fully complementary to a 5′UTR region of a human progranulin mRNA transcript.

6. The antisense oligonucleotide according to any one of paragraphs 1-5, wherein contiguous nucleotide sequence is fully complementary to nucleotides 38-246 of SEQ ID NO 1.

7. The antisense oligonucleotide according to any one of paragraphs 1-6, wherein contiguous nucleotide sequence is fully complementary to SEQ ID NO 2, or SEQ ID NO 689.

8. The antisense oligonucleotide according to any one of paragraphs 1-7, wherein the contiguous nucleotide sequence is fully complementary to a sequence selected from the group consisting of SEQ ID NO 568, 571, 575, 576, 577, 578, 584 & 586.

9. The antisense oligonucleotide according to any one of paragraphs 1-4, wherein contiguous nucleotide sequence is fully complementary to a 3′UTR region of a human progranulin mRNA transcript.

10. The antisense oligonucleotide according to any one of paragraphs 1˜4 or 9, wherein contiguous nucleotide sequence is fully complementary to nucleotides 2039-2346 of SEQ ID NO 1.

11. The antisense oligonucleotide according to any one of paragraphs 1-4, 9 or 10 wherein contiguous nucleotide sequence is fully complementary to a sequence selected from the group consisting of SEQ ID NO 684, 685, 683, 686, 687, and 688.

12. The antisense oligonucleotide according to any one of paragraphs 1-4, 9, 10, or 11 wherein contiguous nucleotide sequence is fully complementary to a sequence selected from the group consisting of SEQ ID NOs 607, 608, 609, 610, 611, 612, 619, 620, 633, 640, 641, 645, 651, and 652.

13. The antisense oligonucleotide according to any one of paragraphs 1-12, wherein contiguous nucleotide sequence is a sequence selected from the group consisting of SEQ ID NO 3-342, or at least 8 or at least 10 contiguous nucleotides thereof.

14. The antisense oligonucleotide according to any one of paragraphs 1-13, wherein the oligonucleotide is or comprises an antisense oligonucleotide mixmer or totalmer.

15. The antisense oligonucleotide of any one of paragraphs 1-14, wherein the antisense oligonucleotide or contiguous nucleotide sequence thereof is 10-20 nucleotides in length.

16. The antisense oligonucleotide according to paragraph 1, wherein the antisense oligonucleotide is selected from the group consisting of COMP ID NOs 3-342.

17. A conjugate comprising the antisense oligonucleotide according to any one of paragraphs 1-16, and at least one conjugate moiety covalently attached to said oligonucleotide.

18. A pharmaceutically acceptable salt of the antisense oligonucleotide according to any one of paragraphs 1-16, or the conjugate according to paragraph 17.

19. The pharmaceutically acceptable salt of paragraph 18, wherein the salt is a sodium salt or a potassium salt.

20. A pharmaceutical composition comprising the antisense oligonucleotide of paragraph 1-16 or the conjugate of paragraph 17 and a pharmaceutically acceptable diluent, solvent, carrier, salt and/or adjuvant.

21. A pharmaceutical composition according to paragraph 20, wherein the pharmaceutical composition comprises the antisense oligonucleotide of paragraph 1-16 or the conjugate of paragraph 17, or the pharmaceutically acceptable salt of paragraph 18 or 19 and an aqueous diluent or solvent, such as phosphate buffered saline.

22. An in vivo or in vitro method for enhancing the expression of progranulin in a cell which is expressing progranulin, said method comprising administering an antisense oligonucleotide of any one of paragraphs 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 in an effective amount to said cell.

23. The method according to paragraph 22, wherein the cell is either a human cell or a mammalian cell.

24. A method for treating or preventing neurological disease comprising administering a therapeutically or prophylactically effective amount of an antisense oligonucleotide of any one of paragraphs 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 to a subject suffering from or susceptible to neurological disease.

25. The antisense oligonucleotide of any one of paragraphs 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 for use as a medicament.

26. The an antisense oligonucleotide of any one of paragraphs 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 for use in the treatment of a neurological disease, such as a TDP-43 pathology.

27. The an antisense oligonucleotide of any one of paragraphs 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 for use in the treatment of progranulin haploinsufficiency.

28. Use of the antisense oligonucleotide of paragraph 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21 for the preparation of a medicament for treatment or prevention of a neurological disease, such as a TDP-43 pathology.

29. Use of the antisense oligonucleotide of paragraph 1-16 or the conjugate according to paragraph 17, or the salt according to paragraph 18 or 19, or the pharmaceutical composition according to paragraph 20 or 21, for the preparation of a medicament for treatment of progranulin haploinsufficiency.

30. The method or use according to any one of paragraphs 22-29, wherein the method or use is for the treatment of fronto temporal dementia (FTD), neuropathologic frontotemporal lobar degeneration or neuroinflammation.

Numbered Embodiments of the Invention

Numbered embodiments of the present invention will now be described.

1. An antisense oligonucleotide progranulin agonist, wherein the antisense oligonucleotide is 8-40 nucleotides in length and comprises a contiguous nucleotide sequence of 8-40 nucleotides in length which are complementary to a human progranulin pre-mRNA or mRNA transcript.

2. The antisense oligonucleotide progranulin agonist according to embodiment 1, wherein the contiguous nucleotide sequence is of a length of at least 12 nucleotides in length.

3. The antisense oligonucleotide progranulin agonist according to embodiment 1 or embodiment 2, wherein the contiguous nucleotide sequence is the same length as the antisense oligonucleotide.

4. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-3, wherein the contiguous nucleotide sequence is complementary to a 5′UTR region of a human progranulin mRNA transcript.

5. The antisense oligonucleotide progranulin agonist according to embodiment 4, wherein the contiguous nucleotide sequence is complementary to SEQ ID NO 2, SEQ ID NO 689, SEQ ID NO 683, or a sequence selected from the group consisting of SEQ ID NO 343-586.

6. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-5, wherein the contiguous nucleotide sequence is selected from SEQ ID NO 105, SEQ ID NO 106, SEQ ID NO 110, SEQ ID NO 113, SEQ ID NO 114, SEQ ID NO 231 and SEQ ID NO 241 or at least 8 or at least 10 contiguous nucleotides thereof.

7. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-3, wherein contiguous nucleotide sequence is complementary to a 3′UTR region of a human progranulin mRNA transcript.

8. The antisense oligonucleotide progranulin agonist according to embodiment 7, wherein the contiguous nucleotide sequence is complementary to SEQ ID NO 684, SEQ ID NO 685, SEQ ID NO 686, SEQ ID NO 687, SEQ ID NO 688, or a sequence selected from the group consisting of SEQ ID NO 587-682.

9. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-8, wherein the antisense oligonucleotide progranulin agonist is or comprises an antisense oligonucleotide mixmer or totalmer.

10. An antisense oligonucleotide progranulin agonist having the structure:

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11. An antisense oligonucleotide progranulin agonist wherein the oligonucleotide is the oligonucleotide compound TgGccAggGatCagGG (SEQ ID NO: 106) wherein capital letters represent beta-D-oxy LNA nucleosides, lowercase letters represent DNA nucleosides, all LNA C are 5-methyl cytosine, and all internucleoside linkages are phosphorothioate internucleoside linkages.

12. An in vivo or in vitro method for enhancing the expression of progranulin in a cell which is expressing progranulin, said method comprising administering an antisense oligonucleotide progranulin agonist according to any one of embodiments 1-11 in an effective amount to said cell.

13. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-11, for use in the treatment of a neurological disease.

14. The antisense oligonucleotide progranulin agonist or pharmaceutical composition for use in the treatment of a neurological disease according to embodiment 13, wherein the neurological disease is a TDP-43 pathology.

15. The antisense oligonucleotide progranulin agonist according to any one of embodiments 1-11 for use in the treatment of progranulin haploinsufficiency.

EXAMPLES
Example 1

GRN 5′ UTR Luciferase Reporter Constructs

The GRN 5′ UTR sequence (SEQ ID #690) was cloned into the psiCHECK2 plasmid (Promega) immediately in front of the renilla luciferase ATG site using the Q5 site-directed mutagenesis kit (New England Biolabs) according to manufacturer's instruction.

5′ UTR sequence from nucleotide number 38 to 256 according to Homo sapiens granulin precursor (GRN), RefSeq NM_002087.3 (SEQ ID NO 1):

SEQ 690

ID#GGCGAGAGGAAGCAGGGAGGAGAGTGATTTGAGTAGAAAAGAAACAC

AGCATTCCAGGCTGGCCCCACCTCTATATTGATAAGTAGCCAATGGGAGC

GGGTAGCCCTGATCCCTGGCCAATGGAAACTGAGGTAGGCGGGTCATCGC

GCTGGGGTCTGTAGTCTGAGCGCTACCCGGTTGCTGCTGCCCAAGGACCG

CGGAGTCGGACGCAGGCAGACC

For the site-directed mutagenesis and insertion of the GRN 5′ UTR the following primers were used:

Forward primer

SEQ ID NO 691

5′-ATGGAAACTGAGGTAGGCGGGTCATCGCGCTGGGGTCTGTAGTCTGA

GCGCTACCCGGTTGCTGCTGCCCAAGGACCGCGGAGTCGGACGCAGGCAG

ACCATGGCTTCCAAGGTGTACGACCCCGAGC-3′

and

reverse primer

SEQ ID NO 692

5′-TGGCCAGGGATCAGGGCTACCCGCTCCCATTGGCTACTTATCAATAT

AGAGGTGGGGCCAGCCTGGAATGCTGTGTTTCTTTTCTACTCAAATCACT

CTCCTCCCTGCTTCCTCTCGCCGGCTAGCCTATAGTGAGTCGTATTAAGT

AC

After transformation of chemical competent bacteria (One Shot TOP10 Chemically Competent E. coli, Thermofisher) and overnight growth on LB agar plates containing ampicillin (imMedia Growth Medium, agar, ampicillin, Thermofisher), single colonies were selected and further grown overnight with constant shaking at 37 Degrees Celcius in LB broth medium containing ampicillin (50 μg/mL) (Thermofisher). Final mini- and midi-prep plasmid purifications were done according to vendors instruction (Qiagen). The inserted 5′ UTR GRN sequences were verified using Sanger sequencing (Eurofins Genomics, Ebersberg, Germany).

Example 2

GRN 3′ UTR Luciferase Reporter Constructs

The GRN 3′ UTR (SEQ ID #2) was cloned into the psiCHECK2 plasmid (Promega) after the renilla luciferase coding sequence using the psiCHECK2 multiple cloning site and the XhoI and NotI restriction sites.

3′ UTR sequence from nucleotide number 2039 to 2346 according to Homo sapiens granulin precursor (GRN), RefSeq NM_002087.3 (SEQ ID NO 1).

SEQ ID#2:

GGGACAGTACTGAAGACTCTGCAGCCCTCGGGACCCCACTCGGAGGGTGC

CCTCTGCTCAGGCCTCCCTAGACCTCCCCCTAACCAAATTCTCCCTGGAC

CCCATTCTGAGCTCCCCATCACCATGGGAGGTGGGGCCTCAATCTAAGGC

CTTCCCTGTCAGAAGGGGGTTGTGGCAAAAGCCACATTACAAGCTGCCAT

CCCCTCCCCGTTTCAGTGGACCCTGTGGCCAGGTGCTTTTCCCTATCCAC

AGGGGTGTTTGTGTGTGTGCGCGTGTGCGTTTCAATAAAGTTTGTACACT

TTCTTAA

Double stranded DNA fragment (gBlock, Integrated DNA technologies) containing the GRN 3′ UTR (SEQ ID #2) flanked by XhoI and NotI sites was cut by XhoI and NotI enzymes (New England Biolabs) according to vendors protocol and ligated using T4 Ligase (New England Biolabs) into the previously XhoI/NotI cut psiCHECK2 plasmid.

After transformation of chemical competent bacteria (One Shot® TOP10 Chemically Competent E. coli, Thermofisher) and overnight growth on LB agar plates containing ampicillin (imMedia Growth Medium, agar, ampicillin, Thermofisher), single colonies were selected and further grown overnight with constant shaking at 37 Degrees Celcius in LB broth medium containing ampicillin (50 μg/mL) (Thermofisher). Final mini- and midiprep plasmid purifications were done according to vendors instruction (Qiagen). The inserted 3′ UTR GRN sequence was verified using Sanger sequencing (Eurofins Genomics, Ebersberg, Germany).

Example 3 Luciferase Reporter Assays

The day before transfection, 15000 Hela cells per well were seeded in 96-well plates (Nunc™ F96 MicroWell™ White Polystyrene Plates) in 100 μL full growth medium. The day at transfection, media is removed and the transfection mixture consisting of 80 μL Opti-MEM Reduced Serum Medium (ThermoFisher Scientific), 6.25 μg/mL Lipofectamine 2000 (ThermoFisher Scientific) and 100 ng psiCHECK2 plasmid with 5′ UTR/3′UTR of GRN is added to each well according to manufacturer's instructions (ThermoFisher Scientific). Shortly after, 20 μL of Opti-MEM Reduced Serum Medium with 500 nM of each antisense oligonucleotide is added to each well for a final concentration of 100 nM. Wells with seeded cells not exposed to transfection reagents are included to correct for background luciferase activity. After 6 hours incubation, transfection mixture is removed from all wells and replaced with full growth medium. The following day, media is removed and replaced with 75 μL PBS, and the Firefly luciferase activity is measured using the Dual-GLo luciferase system (Promega) according to vendors protocol and the EnSight Multimode Plate Reader (Perkin Elmer). Measurement of The firefly luciferase activity is followed by measurement of the renilla luciferase activity. After correction of the background luciferase activity for each well, the relative luciferase activity is calculated by dividing the Renilla luciferase activity by the firefly luciferase activity for each well to correct for transfection efficiency. Finally, for each antisense oligonucleotides the relative luciferase activity is normalized to PBS transfected cells (PBS=1) and values >1 reflects that the respective antisense oligonucleotides have increased the activity/expression of the renilla luciferase activity.

Example 4

Antisense oligonucleotides were designed for the 5′ UTR from position 38 to 241 according to RefSeq NM_002087.3 (SEQ ID NO 1) with one nucleotide basepair shift as shown in table 1, which also provides the data from the luciferase assay, were a value of greater than 1 indicates an increased expression of progranulin (i.e. progranulin agonist activity of the antisense oligonucleotide), and a value lower than 1 indicates a decreased expression of progranulin (i.e. an inhibition or antagonistic effect, on progranulin expression).

TABLE 1

All the antisense oligonucleotides are designed as 16-mers DNA-LNA mixmers with

a phosphorothioate backbone. LNA at the very 5′ and 3′ position

and e.g. LNA for every 2^nd or 3^rd nucleotide (see Compound table).

RefSeq

Relative

Compound
Oligonucleotide
NM_002087.3
Target

luciferase

ID (See
Sequence Motif
(SEQ ID NO 1)
Site

activity

Compound
(nucleobase
Start
End
Sequence
Target
(Relative

SEQ ID
Table)
Sequence)
Position
Position
ID
Site Sequence
to PBS)

SEQ ID 3
COMP ID 3
CCTGCTTCCTCTCGCC
38
53
SEQ ID 343
GGCGAGAGGAAGCAGG
0.47

SEQ ID 4
COMP ID 4
CCCTGCTTCCTCTCGC
39
54
SEQ ID 344
GCGAGAGGAAGCAGGG
0.60

SEQ ID 5
COMP ID 5
TCCCTGCTTCCTCTCG
40
55
SEQ ID 345
CGAGAGGAAGCAGGGA
0.62

SEQ ID 6
COMP ID 6
CTCCCTGCTTCCTCTC
41
56
SEQ ID 346
GAGAGGAAGCAGGGAG
0.65

SEQ ID 7
COMP ID 7
CCTCCCTGCTTCCTCT
42
57
SEQ ID 347
AGAGGAAGCAGGGAGG
0.85

SEQ ID 8
COMP ID 8
TCCTCCCTGCTTCCTC
43
58
SEQ ID 348
GAGGAAGCAGGGAGGA
0.81

SEQ ID 9
COMP ID 9
CTCCTCCCTGCTTCCT
44
59
SEQ ID 349
AGGAAGCAGGGAGGAG
0.53

SEQ ID 10
COMP ID 10
TCTCCTCCCTGCTTCC
45
60
SEQ ID 350
GGAAGCAGGGAGGAGA
0.80

SEQ ID 11
COMP ID 11
CTCTCCTCCCTGCTTC
46
61
SEQ ID 351
GAAGCAGGGAGGAGAG
0.78

SEQ ID 12
COMP ID 12
ACTCTCCTCCCTGCTT
47
62
SEQ ID 352
AAGCAGGGAGGAGAGT
0.78

SEQ ID 13
COMP ID 13
CACTCTCCTCCCTGCT
48
63
SEQ ID 353
AGCAGGGAGGAGAGTG
0.53

SEQ ID 14
COMP ID 14
TCACTCTCCTCCCTGC
49
64
SEQ ID 354
GCAGGGAGGAGAGTGA
0.66

SEQ ID 15
COMP ID 15
ATCACTCTCCTCCCTG
50
65
SEQ ID 355
CAGGGAGGAGAGTGAT
n.d.

SEQ ID 16
COMP ID 16
AATCACTCTCCTCCCT
51
66
SEQ ID 356
AGGGAGGAGAGTGATT
n.d.

SEQ ID 17
COMP ID 17
AAATCACTCTCCTCCC
52
67
SEQ ID 357
GGGAGGAGAGTGATTT
n.d.

SEQ ID 18
COMP ID 18
CAAATCACTCTCCTCC
53
68
SEQ ID 358
GGAGGAGAGTGATTTG
n.d.

SEQ ID 19
COMP ID 19
TCAAATCACTCTCCTC
54
69
SEQ ID 359
GAGGAGAGTGATTTGA
0.56

SEQ ID 20
COMP ID 20
CTCAAATCACTCTCCT
55
70
SEQ ID 360
AGGAGAGTGATTTGAG
0.58

SEQ ID 21
COMP ID 21
ACTCAAATCACTCTCC
56
71
SEQ ID 361
GGAGAGTGATTTGAGT
0.50

SEQ ID 22
COMP ID 22
TACTCAAATCACTCTC
57
72
SEQ ID 362
GAGAGTGATTTGAGTA
0.44

SEQ ID 23
COMP ID 23
CTACTCAAATCACTCT
58
73
SEQ ID 363
AGAGTGATTTGAGTAG
0.61

SEQ ID 24
COMP ID 24
TCTACTCAAATCACTC
59
74
SEQ ID 364
GAGTGATTTGAGTAGA
0.44

SEQ ID 25
COMP ID 25
TTCTACTCAAATCACT
60
75
SEQ ID 365
AGTGATTTGAGTAGAA
0.47

SEQ ID 26
COMP ID 26
TTTCTACTCAAATCAC
61
76
SEQ ID 366
GTGATTTGAGTAGAAA
0.57

SEQ ID 27
COMP ID 27
TTTTCTACTCAAATCA
62
77
SEQ ID 367
TGATTTGAGTAGAAAA
0.49

SEQ ID 28
COMP ID 28
CTTTTCTACTCAAATC
63
78
SEQ ID 368
GATTTGAGTAGAAAAG
0.54

SEQ ID 29
COMP ID 29
TCTTTTCTACTCAAAT
64
79
SEQ ID 369
ATTTGAGTAGAAAAGA
0.49

SEQ ID 30
COMP ID 30
TTCTTTTCTACTCAAA
65
80
SEQ ID 370
TTTGAGTAGAAAAGAA
0.38

SEQ ID 31
COMP ID 31
TTTCTTTTCTACTCAA
66
81
SEQ ID 371
TTGAGTAGAAAAGAAA
0.59

SEQ ID 32
COMP ID 32
GTTTCTTTTCTACTCA
67
82
SEQ ID 372
TGAGTAGAAAAGAAAC
0.44

SEQ ID 33
COMP ID 33
TGTTTCTTTTCTACTC
68
83
SEQ ID 373
GAGTAGAAAAGAAACA
0.61

SEQ ID 34
COMP ID 34
GTGTTTCTTTTCTACT
69
84
SEQ ID 374
AGTAGAAAAGAAACAC
0.56

SEQ ID 35
COMP ID 35
TGTGTTTCTTTTCTAC
70
85
SEQ ID 375
GTAGAAAAGAAACACA
0.47

SEQ ID 36
COMP ID 36
CTGTGTTTCTTTTCTA
71
86
SEQ ID 376
TAGAAAAGAAACACAG
0.36

SEQ ID 37
COMP ID 37
GCTGTGTTTCTTTTCT
72
87
SEQ ID 377
AGAAAAGAAACACAGC
0.45

SEQ ID 38
COMP ID 38
TGCTGTGTTTCTTTTC
73
88
SEQ ID 378
GAAAAGAAACACAGCA
0.58

SEQ ID 39
COMP ID 39
ATGCTGTGTTTCTTTT
74
89
SEQ ID 379
AAAAGAAACACAGCAT
0.77

SEQ ID 40
COMP ID 40
AATGCTGTGTTTCTTT
75
90
SEQ ID 380
AAAGAAACACAGCATT
0.53

SEQ ID 41
COMP ID 41
GAATGCTGTGTTTCTT
76
91
SEQ ID 381
AAGAAACACAGCATTC
0.73

SEQ ID 42
COMP ID 42
GGAATGCTGTGTTTCT
77
92
SEQ ID 382
AGAAACACAGCATTCC
0.77

SEQ ID 43
COMP ID 43
TGGAATGCTGTGTTTC
78
93
SEQ ID 383
GAAACACAGCATTCCA
0.69

SEQ ID 44
COMP ID 44
CTGGAATGCTGTGTTT
79
94
SEQ ID 384
AAACACAGCATTCCAG
0.63

SEQ ID 45
COMP ID 45
CCTGGAATGCTGTGTT
80
95
SEQ ID 385
AACACAGCATTCCAGG
0.58

SEQ ID 46
COMP ID 46
GCCTGGAATGCTGTGT
81
96
SEQ ID 386
ACACAGCATTCCAGGC
0.57

SEQ ID 47
COMP ID 47
AGCCTGGAATGCTGTG
82
97
SEQ ID 387
CACAGCATTCCAGGCT
0.48

SEQ ID 48
COMP ID 48
CAGCCTGGAATGCTGT
83
98
SEQ ID 388
ACAGCATTCCAGGCTG
0.62

SEQ ID 49
COMP ID 49
CCAGCCTGGAATGCTG
84
99
SEQ ID 389
CAGCATTCCAGGCTGG
0.40

SEQ ID 50
COMP ID 50
GCCAGCCTGGAATGCT
85
100
SEQ ID 390
AGCATTCCAGGCTGGC
0.32

SEQ ID 51
COMP ID 51
GGCCAGCCTGGAATGC
86
101
SEQ ID 391
GCATTCCAGGCTGGCC
0.24

SEQ ID 52
COMP ID 52
GGGCCAGCCTGGAATG
87
102
SEQ ID 392
CATTCCAGGCTGGCCC
0.15

SEQ ID 53
COMP ID 53
GGGGCCAGCCTGGAAT
88
103
SEQ ID 393
ATTCCAGGCTGGCCCC
0.20

SEQ ID 54
COMP ID 54
TGGGGCCAGCCTGGAA
89
104
SEQ ID 394
TTCCAGGCTGGCCCCA
0.62

SEQ ID 55
COMP ID 55
GTGGGGCCAGCCTGGA
90
105
SEQ ID 395
TCCAGGCTGGCCCCAC
0.54

SEQ ID 56
COMP ID 56
GGTGGGGCCAGCCTGG
91
106
SEQ ID 396
CCAGGCTGGCCCCACC
0.62

SEQ ID 57
COMP ID 57
AGGTGGGGCCAGCCTG
92
107
SEQ ID 397
CAGGCTGGCCCCACCT
0.38

SEQ ID 58
COMP ID 58
GAGGTGGGGCCAGCCT
93
108
SEQ ID 398
AGGCTGGCCCCACCTC
0.46

SEQ ID 59
COMP ID 59
AGAGGTGGGGCCAGCC
94
109
SEQ ID 399
GGCTGGCCCCACCTCT
0.32

SEQ ID 60
COMP ID 60
TAGAGGTGGGGCCAGC
95
110
SEQ ID 400
GCTGGCCCCACCTCTA
0.53

SEQ ID 61
COMP ID 61
ATAGAGGTGGGGCCAG
96
111
SEQ ID 401
CTGGCCCCACCTCTAT
0.37

SEQ ID 62
COMP ID 62
TATAGAGGTGGGGCCA
97
112
SEQ ID 402
TGGCCCCACCTCTATA
0.68

SEQ ID 63
COMP ID 63
ATATAGAGGTGGGGCC
98
113
SEQ ID 403
GGCCCCACCTCTATAT
0.65

SEQ ID 64
COMP ID 64
AATATAGAGGTGGGGC
99
114
SEQ ID 404
GCCCCACCTCTATATT
0.61

SEQ ID 65
COMP ID 65
CAATATAGAGGTGGGG
100
115
SEQ ID 405
CCCCACCTCTATATTG
0.79

SEQ ID 66
COMP ID 66
TCAATATAGAGGTGGG
101
116
SEQ ID 406
CCCACCTCTATATTGA
0.86

SEQ ID 67
COMP ID 67
ATCAATATAGAGGTGG
102
117
SEQ ID 407
CCACCTCTATATTGAT
0.80

SEQ ID 68
COMP ID 68
TATCAATATAGAGGTG
103
118
SEQ ID 408
CACCTCTATATTGATA
0.65

SEQ ID 69
COMP ID 69
TTATCAATATAGAGGT
104
119
SEQ ID 409
ACCTCTATATTGATAA
0.49

SEQ ID 70
COMP ID 70
CTTATCAATATAGAGG
105
120
SEQ ID 410
CCTCTATATTGATAAG
0.93

SEQ ID 71
COMP ID 71
ACTTATCAATATAGAG
106
121
SEQ ID 411
CTCTATATTGATAAGT
0.73

SEQ ID 72
COMP ID 72
TACTTATCAATATAGA
107
122
SEQ ID 412
TCTATATTGATAAGTA
0.87

SEQ ID 73
COMP ID 73
CTACTTATCAATATAG
108
123
SEQ ID 413
CTATATTGATAAGTAG
0.83

SEQ ID 74
COMP ID 74
GCTACTTATCAATATA
109
124
SEQ ID 414
TATATTGATAAGTAGC
0.64

SEQ ID 75
COMP ID 75
GGCTACTTATCAATAT
110
125
SEQ ID 415
ATATTGATAAGTAGCC
0.71

SEQ ID 76
COMP ID 76
TGGCTACTTATCAATA
111
126
SEQ ID 416
TATTGATAAGTAGCCA
0.81

SEQ ID 77
COMP ID 77
TTGGCTACTTATCAAT
112
127
SEQ ID 417
ATTGATAAGTAGCCAA
0.48

SEQ ID 78
COMP ID 78
ATTGGCTACTTATCAA
113
128
SEQ ID 418
TTGATAAGTAGCCAAT
0.88

SEQ ID 79
COMP ID 79
CATTGGCTACTTATCA
114
129
SEQ ID 419
TGATAAGTAGCCAATG
0.72

SEQ ID 80
COMP ID 80
CCATTGGCTACTTATC
115
130
SEQ ID 420
GATAAGTAGCCAATGG
0.53

SEQ ID 81
COMP ID 81
CCCATTGGCTACTTAT
116
131
SEQ ID 421
ATAAGTAGCCAATGGG
0.63

SEQ ID 82
COMP ID 82
TCCCATTGGCTACTTA
117
132
SEQ ID 422
TAAGTAGCCAATGGGA
0.53

SEQ ID 83
COMP ID 83
CTCCCATTGGCTACTT
118
133
SEQ ID 423
AAGTAGCCAATGGGAG
0.57

SEQ ID 84
COMP ID 84
GCTCCCATTGGCTACT
119
134
SEQ ID 424
AGTAGCCAATGGGAGC
0.52

SEQ ID 85
COMP ID 85
CGCTCCCATTGGCTAC
120
135
SEQ ID 425
GTAGCCAATGGGAGCG
0.25

SEQ ID 86
COMP ID 86
CCGCTCCCATTGGCTA
121
136
SEQ ID 426
TAGCCAATGGGAGCGG
0.37

SEQ ID 87
COMP ID 87
CCCGCTCCCATTGGCT
122
137
SEQ ID 427
AGCCAATGGGAGCGGG
0.28

SEQ ID 88
COMP ID 88
ACCCGCTCCCATTGGC
123
138
SEQ ID 428
GCCAATGGGAGCGGGT
0.30

SEQ ID 89
COMP ID 89
TACCCGCTCCCATTGG
124
139
SEQ ID 429
CCAATGGGAGCGGGTA
0.43

SEQ ID 90
COMP ID 90
CTACCCGCTCCCATTG
125
140
SEQ ID 430
CAATGGGAGCGGGTAG
0.38

SEQ ID 91
COMP ID 91
GCTACCCGCTCCCATT
126
141
SEQ ID 431
AATGGGAGCGGGTAGC
0.65

SEQ ID 92
COMP ID 92
GGCTACCCGCTCCCAT
127
142
SEQ ID 432
ATGGGAGCGGGTAGCC
0.51

SEQ ID 93
COMP ID 93
GGGCTACCCGCTCCCA
128
143
SEQ ID 433
TGGGAGCGGGTAGCCC
0.38

SEQ ID 94
COMP ID 94
AGGGCTACCCGCTCCC
129
144
SEQ ID 434
GGGAGCGGGTAGCCCT
0.50

SEQ ID 95
COMP ID 95
CAGGGCTACCCGCTCC
130
145
SEQ ID 435
GGAGCGGGTAGCCCTG
0.45

SEQ ID 96
COMP ID 96
TCAGGGCTACCCGCTC
131
146
SEQ ID 436
GAGCGGGTAGCCCTGA
0.50

SEQ ID 97
COMP ID 97
ATCAGGGCTACCCGCT
132
147
SEQ ID 437
AGCGGGTAGCCCTGAT
0.39

SEQ ID 98
COMP ID 98
GATCAGGGCTACCCGC
133
148
SEQ ID 438
GCGGGTAGCCCTGATC
0.31

SEQ ID 99
COMP ID 99
GGATCAGGGCTACCCG
134
149
SEQ ID 439
CGGGTAGCCCTGATCC
0.32

SEQ ID 100
COMP ID 100
GGGATCAGGGCTACCC
135
150
SEQ ID 440
GGGTAGCCCTGATCCC
0.56

SEQ ID 101
COMP ID 101
AGGGATCAGGGCTACC
136
151
SEQ ID 441
GGTAGCCCTGATCCCT
0.41

SEQ ID 102
COMP ID 102
CAGGGATCAGGGCTAC
137
152
SEQ ID 442
GTAGCCCTGATCCCTG
0.86

SEQ ID 103
COMP ID 103
CCAGGGATCAGGGCTA
138
153
SEQ ID 443
TAGCCCTGATCCCTGG
0.65

SEQ ID 104
COMP ID 104
GCCAGGGATCAGGGCT
139
154
SEQ ID 444
AGCCCTGATCCCTGGC
0.65

SEQ ID 105
COMP ID 105
GGCCAGGGATCAGGGC
140
155
SEQ ID 445
GCCCTGATCCCTGGCC
1.00

SEQ ID 106
COMP ID 106
TGGCCAGGGATCAGGG
141
156
SEQ ID 446
CCCTGATCCCTGGCCA
1.07

SEQ ID 107
COMP ID 107
TTGGCCAGGGATCAGG
142
157
SEQ ID 447
CCTGATCCCTGGCCAA
0.52

SEQ ID 108
COMP ID 108
ATTGGCCAGGGATCAG
143
158
SEQ ID 448
CTGATCCCTGGCCAAT
0.86

SEQ ID 109
COMP ID 109
CATTGGCCAGGGATCA
144
159
SEQ ID 449
TGATCCCTGGCCAATG
0.67

SEQ ID 110
COMP ID 110
CCATTGGCCAGGGATC
145
160
SEQ ID 450
GATCCCTGGCCAATGG
0.54

SEQ ID 111
COMP ID 111
TCCATTGGCCAGGGAT
146
161
SEQ ID 451
ATCCCTGGCCAATGGA
n.d.

SEQ ID 112
COMP ID 112
TTCCATTGGCCAGGGA
147
162
SEQ ID 452
TCCCTGGCCAATGGAA
n.d.

SEQ ID 113
COMP ID 113
TTTCCATTGGCCAGGG
148
163
SEQ ID 453
CCCTGGCCAATGGAAA
n.d.

SEQ ID 114
COMP ID 114
GTTTCCATTGGCCAGG
149
164
SEQ ID 454
CCTGGCCAATGGAAAC
n.d.

SEQ ID 115
COMP ID 115
AGTTTCCATTGGCCAG
150
165
SEQ ID 455
CTGGCCAATGGAAACT
0.43

SEQ ID 116
COMP ID 116
CAGTTTCCATTGGCCA
151
166
SEQ ID 456
TGGCCAATGGAAACTG
0.56

SEQ ID 117
COMP ID 117
TCAGTTTCCATTGGCC
152
167
SEQ ID 457
GGCCAATGGAAACTGA
0.61

SEQ ID 118
COMP ID 118
CTCAGTTTCCATTGGC
153
168
SEQ ID 458
GCCAATGGAAACTGAG
0.71

SEQ ID 119
COMP ID 119
CCTCAGTTTCCATTGG
154
169
SEQ ID 459
CCAATGGAAACTGAGG
1.03

SEQ ID 120
COMP ID 120
ACCTCAGTTTCCATTG
155
170
SEQ ID 460
CAATGGAAACTGAGGT
0.90

SEQ ID 121
COMP ID 121
TACCTCAGTTTCCATT
156
171
SEQ ID 461
AATGGAAACTGAGGTA
0.95

SEQ ID 122
COMP ID 122
CTACCTCAGTTTCCAT
157
172
SEQ ID 462
ATGGAAACTGAGGTAG
0.63

SEQ ID 123
COMP ID 123
CCTACCTCAGTTTCCA
158
173
SEQ ID 463
TGGAAACTGAGGTAGG
0.62

SEQ ID 124
COMP ID 124
GCCTACCTCAGTTTCC
159
174
SEQ ID 464
GGAAACTGAGGTAGGC
0.49

SEQ ID 125
COMP ID 125
CGCCTACCTCAGTTTC
160
175
SEQ ID 465
GAAACTGAGGTAGGCG
1.18

SEQ ID 126
COMP ID 126
CCGCCTACCTCAGTTT
161
176
SEQ ID 466
AAACTGAGGTAGGCGG
0.55

SEQ ID 127
COMP ID 127
CCCGCCTACCTCAGTT
162
177
SEQ ID 467
AACTGAGGTAGGCGGG
0.72

SEQ ID 128
COMP ID 128
ACCCGCCTACCTCAGT
163
178
SEQ ID 468
ACTGAGGTAGGCGGGT
0.44

SEQ ID 129
COMP ID 129
GACCCGCCTACCTCAG
164
179
SEQ ID 469
CTGAGGTAGGCGGGTC
0.42

SEQ ID 130
COMP ID 130
TGACCCGCCTACCTCA
165
180
SEQ ID 470
TGAGGTAGGCGGGTCA
0.28

SEQ ID 131
COMP ID 131
ATGACCCGCCTACCTC
166
181
SEQ ID 471
GAGGTAGGCGGGTCAT
0.19

SEQ ID 132
COMP ID 132
GATGACCCGCCTACCT
167
182
SEQ ID 472
AGGTAGGCGGGTCATC
0.18

SEQ ID 133
COMP ID 133
CGATGACCCGCCTACC
168
183
SEQ ID 473
GGTAGGCGGGTCATCG
0.34

SEQ ID 134
COMP ID 134
GCGATGACCCGCCTAC
169
184
SEQ ID 474
GTAGGCGGGTCATCGC
0.73

SEQ ID 135
COMP ID 135
CGCGATGACCCGCCTA
170
185
SEQ ID 475
TAGGCGGGTCATCGCG
0.66

SEQ ID 136
COMP ID 136
GCGCGATGACCCGCCT
171
186
SEQ ID 476
AGGCGGGTCATCGCGC
0.46

SEQ ID 137
COMP ID 137
AGCGCGATGACCCGCC
172
187
SEQ ID 477
GGCGGGTCATCGCGCT
0.46

SEQ ID 138
COMP ID 138
CAGCGCGATGACCCGC
173
188
SEQ ID 478
GCGGGTCATCGCGCTG
0.53

SEQ ID 139
COMP ID 139
CCAGCGCGATGACCCG
174
189
SEQ ID 479
CGGGTCATCGCGCTGG
0.23

SEQ ID 140
COMP ID 140
CCCAGCGCGATGACCC
175
190
SEQ ID 480
GGGTCATCGCGCTGGG
0.23

SEQ ID 141
COMP ID 141
CCCCAGCGCGATGACC
176
191
SEQ ID 481
GGTCATCGCGCTGGGG
0.42

SEQ ID 142
COMP ID 142
ACCCCAGCGCGATGAC
177
192
SEQ ID 482
GTCATCGCGCTGGGGT
0.30

SEQ ID 143
COMP ID 143
GACCCCAGCGCGATGA
178
193
SEQ ID 483
TCATCGCGCTGGGGTC
0.63

SEQ ID 144
COMP ID 144
AGACCCCAGCGCGATG
179
194
SEQ ID 484
CATCGCGCTGGGGTCT
0.57

SEQ ID 145
COMP ID 145
CAGACCCCAGCGCGAT
180
195
SEQ ID 485
ATCGCGCTGGGGTCTG
0.31

SEQ ID 146
COMP ID 146
ACAGACCCCAGCGCGA
181
196
SEQ ID 486
TCGCGCTGGGGTCTGT
0.29

SEQ ID 147
COMP ID 147
TACAGACCCCAGCGCG
182
197
SEQ ID 487
CGCGCTGGGGTCTGTA
0.34

SEQ ID 148
COMP ID 148
CTACAGACCCCAGCGC
183
198
SEQ ID 488
GCGCTGGGGTCTGTAG
0.32

SEQ ID 149
COMP ID 149
ACTACAGACCCCAGCG
184
199
SEQ ID 489
CGCTGGGGTCTGTAGT
0.34

SEQ ID 150
COMP ID 150
GACTACAGACCCCAGC
185
200
SEQ ID 490
GCTGGGGTCTGTAGTC
0.64

SEQ ID 151
COMP ID 151
AGACTACAGACCCCAG
186
201
SEQ ID 491
CTGGGGTCTGTAGTCT
0.95

SEQ ID 152
COMP ID 152
CAGACTACAGACCCCA
187
202
SEQ ID 492
TGGGGTCTGTAGTCTG
0.52

SEQ ID 153
COMP ID 153
TCAGACTACAGACCCC
188
203
SEQ ID 493
GGGGTCTGTAGTCTGA
0.53

SEQ ID 154
COMP ID 154
CTCAGACTACAGACCC
189
204
SEQ ID 494
GGGTCTGTAGTCTGAG
0.43

SEQ ID 155
COMP ID 155
GCTCAGACTACAGACC
190
205
SEQ ID 495
GGTCTGTAGTCTGAGC
0.33

SEQ ID 156
COMP ID 156
CGCTCAGACTACAGAC
191
206
SEQ ID 496
GTCTGTAGTCTGAGCG
0.43

SEQ ID 157
COMP ID 157
GCGCTCAGACTACAGA
192
207
SEQ ID 497
TCTGTAGTCTGAGCGC
0.46

SEQ ID 158
COMP ID 158
AGCGCTCAGACTACAG
193
208
SEQ ID 498
CTGTAGTCTGAGCGCT
0.80

SEQ ID 159
COMP ID 159
TAGCGCTCAGACTACA
194
209
SEQ ID 499
TGTAGTCTGAGCGCTA
0.47

SEQ ID 160
COMP ID 160
GTAGCGCTCAGACTAC
195
210
SEQ ID 500
GTAGTCTGAGCGCTAC
0.67

SEQ ID 161
COMP ID 161
GGTAGCGCTCAGACTA
196
211
SEQ ID 501
TAGTCTGAGCGCTACC
0.74

SEQ ID 162
COMP ID 162
GGGTAGCGCTCAGACT
197
212
SEQ ID 502
AGTCTGAGCGCTACCC
0.62

SEQ ID 163
COMP ID 163
CGGGTAGCGCTCAGAC
198
213
SEQ ID 503
GTCTGAGCGCTACCCG
0.43

SEQ ID 164
COMP ID 164
CCGGGTAGCGCTCAGA
199
214
SEQ ID 504
TCTGAGCGCTACCCGG
0.38

SEQ ID 165
COMP ID 165
ACCGGGTAGCGCTCAG
200
215
SEQ ID 505
CTGAGCGCTACCCGGT
0.45

SEQ ID 166
COMP ID 166
AACCGGGTAGCGCTCA
201
216
SEQ ID 506
TGAGCGCTACCCGGTT
0.61

SEQ ID 167
COMP ID 167
CAACCGGGTAGCGCTC
202
217
SEQ ID 507
GAGCGCTACCCGGTTG
0.56

SEQ ID 168
COMP ID 168
GCAACCGGGTAGCGCT
203
218
SEQ ID 508
AGCGCTACCCGGTTGC
0.50

SEQ ID 169
COMP ID 169
AGCAACCGGGTAGCGC
204
219
SEQ ID 509
GCGCTACCCGGTTGCT
0.35

SEQ ID 170
COMP ID 170
CAGCAACCGGGTAGCG
205
220
SEQ ID 510
CGCTACCCGGTTGCTG
0.21

SEQ ID 171
COMP ID 171
GCAGCAACCGGGTAGC
206
221
SEQ ID 511
GCTACCCGGTTGCTGC
0.19

SEQ ID 172
COMP ID 172
AGCAGCAACCGGGTAG
207
222
SEQ ID 512
CTACCCGGTTGCTGCT
0.26

SEQ ID 173
COMP ID 173
CAGCAGCAACCGGGTA
208
223
SEQ ID 513
TACCCGGTTGCTGCTG
0.22

SEQ ID 174
COMP ID 174
GCAGCAGCAACCGGGT
209
224
SEQ ID 514
ACCCGGTTGCTGCTGC
0.42

SEQ ID 175
COMP ID 175
GGCAGCAGCAACCGGG
210
225
SEQ ID 515
CCCGGTTGCTGCTGCC
0.41

SEQ ID 176
COMP ID 176
GGGCAGCAGCAACCGG
211
226
SEQ ID 516
CCGGTTGCTGCTGCCC
0.44

SEQ ID 177
COMP ID 177
TGGGCAGCAGCAACCG
212
227
SEQ ID 517
CGGTTGCTGCTGCCCA
0.42

SEQ ID 178
COMP ID 178
TTGGGCAGCAGCAACC
213
228
SEQ ID 518
GGTTGCTGCTGCCCAA
0.36

SEQ ID 179
COMP ID 179
CTTGGGCAGCAGCAAC
214
229
SEQ ID 519
GTTGCTGCTGCCCAAG
0.28

SEQ ID 180
COMP ID 180
CCTTGGGCAGCAGCAA
215
230
SEQ ID 520
TTGCTGCTGCCCAAGG
0.31

SEQ ID 181
COMP ID 181
TCCTTGGGCAGCAGCA
216
231
SEQ ID 521
TGCTGCTGCCCAAGGA
0.26

SEQ ID 182
COMP ID 182
GTCCTTGGGCAGCAGC
217
232
SEQ ID 522
GCTGCTGCCCAAGGAC
0.60

SEQ ID 183
COMP ID 183
GGTCCTTGGGCAGCAG
218
233
SEQ ID 523
CTGCTGCCCAAGGACC
0.39

SEQ ID 184
COMP ID 184
CGGTCCTTGGGCAGCA
219
234
SEQ ID 524
TGCTGCCCAAGGACCG
0.30

SEQ ID 185
COMP ID 185
GCGGTCCTTGGGCAGC
220
235
SEQ ID 525
GCTGCCCAAGGACCGC
0.44

SEQ ID 186
COMP ID 186
CGCGGTCCTTGGGCAG
221
236
SEQ ID 526
CTGCCCAAGGACCGCG
0.21

SEQ ID 187
COMP ID 187
CCGCGGTCCTTGGGCA
222
237
SEQ ID 527
TGCCCAAGGACCGCGG
0.25

SEQ ID 188
COMP ID 188
TCCGCGGTCCTTGGGC
223
238
SEQ ID 528
GCCCAAGGACCGCGGA
0.21

SEQ ID 189
COMP ID 189
CTCCGCGGTCCTTGGG
224
239
SEQ ID 529
CCCAAGGACCGCGGAG
0.25

SEQ ID 190
COMP ID 190
ACTCCGCGGTCCTTGG
225
240
SEQ ID 530
CCAAGGACCGCGGAGT
0.55

SEQ ID 191
COMP ID 191
GACTCCGCGGTCCTTG
226
241
SEQ ID 531
CAAGGACCGCGGAGTC
0.33

SEQ ID 192
COMP ID 192
CGACTCCGCGGTCCTT
227
242
SEQ ID 532
AAGGACCGCGGAGTCG
0.49

SEQ ID 193
COMP ID 193
CCGACTCCGCGGTCCT
228
243
SEQ ID 533
AGGACCGCGGAGTCGG
0.23

SEQ ID 194
COMP ID 194
TCCGACTCCGCGGTCC
229
244
SEQ ID 534
GGACCGCGGAGTCGGA
0.20

SEQ ID 195
COMP ID 195
GTCCGACTCCGCGGTC
230
245
SEQ ID 535
GACCGCGGAGTCGGAC
0.25

SEQ ID 196
COMP ID 196
CGTCCGACTCCGCGGT
231
246
SEQ ID 536
ACCGCGGAGTCGGACG
0.55

SEQ ID 197
COMP ID 197
GCGTCCGACTCCGCGG
232
247
SEQ ID 537
CCGCGGAGTCGGACGC
0.41

SEQ ID 198
COMP ID 198
TGCGTCCGACTCCGCT
233
248
SEQ ID 538
CGCGGAGTCGGACGCA
0.33

SEQ ID 199
COMP ID 199
CTGCGTCCGACTCCGC
234
249
SEQ ID 539
GCGGAGTCGGACGCAG
0,180.47

SEQ ID 200
COMP ID 200
CCTGCGTCCGACTCCG
235
250
SEQ ID 540
CGGAGTCGGACGCAGG
0,140.60

SEQ ID 201
COMP ID 201
GCCTGCGTCCGACTCC
236
251
SEQ ID 541
GGAGTCGGACGCAGGC
0,150.62

SEQ ID 202
COMP ID 202
TGCCTGCGTCCGACTC
237
252
SEQ ID 542
GAGTCGGACGCAGGCA
0,230.65

SEQ ID 203
COMP ID 203
CTGCCTGCGTCCGACT
238
253
SEQ ID 543
AGTCGGACGCAGGCAG
0,270.85

SEQ ID 204
COMP ID 204
TCTGCCTGCGTCCGAC
239
254
SEQ ID 544
GTCGGACGCAGGCAGA
0,270.81

SEQ ID 205
COMP ID 205
GTCTGCCTGCGTCCGA
240
255
SEQ ID 545
TCGGACGCAGGCAGAC
0,220.53

SEQ ID 206
COMP ID 206
GGTCTGCCTGCGTCCG
241
256
SEQ ID 546
CGGACGCAGGCAGACC
0,330.80

Example 5

Antisense oligonucleotides were designed for the 5′ UTR from position 119 to 158 according to RefSeq NM_002087.3 (SEQ ID NO 1) with one nucleotide basepair shift as shown in table 2, which also provides the data from the luciferase assay, were a value of greater than 1 indicates an increased expression of progranulin (i.e. progranulin agonist activity of the antisense oligonucleotide), and a value lower than 1 indicates a decreased expression of progranulin (i.e. an inhibition or antagonistic effect, on progranulin expression).

The results from example 4 and 5 show that antisense oligonucleotide agonism was identified for several compounds targeting the progranulin 5′UTR, particularly compounds with a contiguous nucleotide complementary to nucleotides 1-229 of SEQ ID NO 1, such as compounds complementary to SEQ ID NO 445, SEQ ID NO: 446, SEQ ID NO: 459, SEQ ID NO 465, SEQ ID NO 683, SEQ ID NO 568, SEQ ID NO 571, SEQ ID NO 575, SEQ ID NO 576, SEQ ID NO 577, SEQ ID NO 578, SEQ ID NO 584, & SEQ ID NO 586.

Compounds 105, 106, 119, 125, 117, 228, 231, 235-8, 244 and 246 were identified as having progranulin agonist activity in the luciferase assay.

TABLE 2

All the antisense oligonucleotides are designed as 18-mers DNA-LNA mixmers with a

phosphorothioate backbone, DNA-LNA mixmers with a phosphorothioate backbone, LNA at the

very 5′ and 3′ position and e.g. LNA for every 2^ndor 3^rd nucleotide (see Compound table).

Compound

ID

RefSeq

Relative

number

NM_002087.3
Target

luciferase

-See
Oligonucleotide
(SEQ ID NO 1)
Site

activity

Compound
Sequence Motif
Start
End
Sequence

Relative

SEQ ID
Table
(nucleobase Sequence)
Position
Position
ID
Target Site Sequence
to PBS)

SEQ
COMP ID
GCTCCCATTGGCTACTTA
119
136
SEQ ID
TAAGTAGCCAATGGGAGC
0.32

ID#207
207

547

SEQ
COMP ID
CGCTCCCATTGGCTACTT
120
137
SEQ ID
AAGTAGCCAATGGGAGCG
0.22

ID#208
208

548

SEQ
COMP ID
CCGCTCCCATTGGCTACT
121
138
SEQ ID
AGTAGCCAATGGGAGCGG
0.19

ID#209
209

549

SEQ
COMP ID
CCCGCTCCCATTGGCTAC
122
139
SEQ ID
GTAGCCAATGGGAGCGGG
0.24

ID#210
210

550

SEQ
COMP ID
ACCCGCTCCCATTGGCTA
123
140
SEQ ID
TAGCCAATGGGAGCGGGT
0.37

ID#211
211

551

SEQ
COMP ID
TACCCGCTCCCATTGGCT
124
141
SEQ ID
AGCCAATGGGAGCGGGTA
0.38

ID#212
212

552

SEQ
COMP ID
CTACCCGCTCCCATTGGC
125
142
SEQ ID
GCCAATGGGAGCGGGTAG
0.39

ID#213
213

553

SEQ
COMP ID
GCTACCCGCTCCCATTGG
126
143
SEQ ID
CCAATGGGAGCGGGTAGC
0.47

ID#214
214

554

SEQ
COMP ID
GGCTACCCGCTCCCATTG
127
144
SEQ ID
CAATGGGAGCGGGTAGCC
0.55

ID#215
215

555

SEQ
COMP ID
GGGCTACCCGCTCCCATT
128
145
SEQ ID
AATGGGAGCGGGTAGCCC
0.53

ID#216
216

556

SEQ
COMP ID
AGGGCTACCCGCTCCCAT
129
146
SEQ ID
ATGGGAGCGGGTAGCCCT
0.56

ID#217
217

557

SEQ
COMP ID
CAGGGCTACCCGCTCCCA
130
147
SEQ ID
TGGGAGCGGGTAGCCCTG
0.49

ID#218
218

558

SEQ
COMP ID
TCAGGGCTACCCGCTCCC
131
148
SEQ ID
GGGAGCGGGTAGCCCTGA
0.58

ID#219
219

559

SEQ
COMP ID
ATCAGGGCTACCCGCTCC
132
149
SEQ ID
GGAGCGGGTAGCCCTGAT
0.48

ID#220
220

560

SEQ
COMP ID
GATCAGGGCTACCCGCTC
133
150
SEQ ID
GAGCGGGTAGCCCTGATC
0.49

ID#221
221

561

SEQ
COMP ID
GGATCAGGGCTACCCGCT
134
151
SEQ ID
AGCGGGTAGCCCTGATCC
0.38

ID#222
222

562

SEQ
COMP ID
GGGATCAGGGCTACCCGC
135
152
SEQ ID
GCGGGTAGCCCTGATCCC
0.33

ID#223
223

563

SEQ
COMP ID
AGGGATCAGGGCTACCCG
136
153
SEQ ID
CGGGTAGCCCTGATCCCT
0.36

ID#224
224

564

SEQ
COMP ID
CAGGGATCAGGGCTACCC
137
154
SEQ ID
GGGTAGCCCTGATCCCTG
0.48

ID#225
225

565

SEQ
COMP ID
CCAGGGATCAGGGCTACC
138
155
SEQ ID
GGTAGCCCTGATCCCTGG
0.69

ID#226
226

566

SEQ
COMP ID
GCCAGGGATCAGGGCTAC
139
156
SEQ ID
GTAGCCCTGATCCCTGGC
0.94

ID#227
227

567

SEQ
COMP ID
GGCCAGGGATCAGGGCTA
140
157
SEQ ID
TAGCCCTGATCCCTGGCC
1.15

ID#228
228

568

SEQ
COMP ID
TGGCCAGGGATCAGGGCT
141
158
SEQ ID
AGCCCTGATCCCTGGCCA
0.92

ID#229
229

569

SEQ
COMP ID
TTGGCCAGGGATCAGGGC
142
159
SEQ ID
GCCCTGATCCCTGGCCAA
0.85

ID#230
230

570

SEQ
COMP ID
ATTGGCCAGGGATCAGGG
143
160
SEQ ID
CCCTGATCCCTGGCCAAT
1.12

ID#231
231

571

SEQ
COMP ID
CATTGGCCAGGGATCAGG
144
161
SEQ ID
CCTGATCCCTGGCCAATG
0.72

ID#232
232

572

SEQ
COMP ID
CCATTGGCCAGGGATCAG
145
162
SEQ ID
CTGATCCCTGGCCAATGG
0.75

ID#233
233

573

SEQ
COMP ID
TCCATTGGCCAGGGATCA
146
163
SEQ ID
TGATCCCTGGCCAATGGA
0.97

ID#234
234

574

SEQ
COMP ID
TTCCATTGGCCAGGGATC
147
164
SEQ ID
GATCCCTGGCCAATGGAA
1.22

ID#235
235

575

SEQ
COMP ID
TTTCCATTGGCCAGGGAT
148
165
SEQ ID
ATCCCTGGCCAATGGAAA
1.13

ID#236
236

576

SEQ
COMP ID
GTTTCCATTGGCCAGGGA
149
166
SEQ ID
TCCCTGGCCAATGGAAAC
1.01

ID#237
237

577

SEQ
COMP ID
AGTTTCCATTGGCCAGGG
150
167
SEQ ID
CCCTGGCCAATGGAAACT
1.09

ID#238
238

578

SEQ
COMP ID
CAGTTTCCATTGGCCAGG
151
168
SEQ ID
CCTGGCCAATGGAAACTG
0.79

ID#239
239

579

SEQ
COMP ID
TCAGTTTCCATTGGCCAG
152
169
SEQ ID
CTGGCCAATGGAAACTGA
0.69

ID#240
240

580

SEQ
COMP ID
CTCAGTTTCCATTGGCCA
153
170
SEQ ID
TGGCCAATGGAAACTGAG
0.59

ID#241
241

581

SEQ
COMP ID
CCTCAGTTTCCATTGGCC
154
171
SEQ ID
GGCCAATGGAAACTGAGG
0.39

ID#242
242

582

SEQ
COMP ID
ACCTCAGTTTCCATTGGC
155
172
SEQ ID
GCCAATGGAAACTGAGGT
0.95

ID#243
243

583

SEQ
COMP ID
TACCTCAGTTTCCATTGG
156
173
SEQ ID
CCAATGGAAACTGAGGTA
1.12

ID#244
244

584

SEQ
COMP ID
CTACCTCAGTTTCCATTG
157
174
SEQ ID
CAATGGAAACTGAGGTAG
1.00

ID#245
245

585

SEQ
COMP ID
CCTACCTCAGTTTCCATT
158
175
SEQ ID
AATGGAAACTGAGGTAGG
1.26

ID#246
246

586

Example 6

Antisense oligonucleotides were designed for the 3′ UTR from position 2044 to 2346 according to RefSeq NM_002807.3 with three nucleotide basepair shift as shown in table 3 which also provides the data from the luciferase assay, were a value of greater than 1 indicates an increased expression of progranulin (i.e. progranulin agonist activity of the antisense oligonucleotide), and a value lower than 1 indicates a decreased expression of progranulin (i.e. an inhibition or antagonistic effect, on progranulin expression).

The data shows antisense oligonucleotide antisense oligonucleotides with progranulin agonist activity that are complementary to the 3′UTR region of a human progranulin mRNA transcript were identified, for example compounds with a contiguous nucleotide sequence which is complementary to a sequence selected from the group consisting of SEQ ID NO 684, 685, 683, 686, 687, and 688, such as compounds with a contiguous nucleotide sequence which is complementary to a sequence selected from the group consisting of 607, 608, 609, 610, 611, 612, 619, 620, 633, 640, 641,645, 651, and 652.

Compounds 263, 267, 269-272, 279, 280, 293, 300, 301, 305, 311, 312 and 327 were identified as exhibiting progranulin agonist activity in the luciferase assay system used.

TABLE 3

All the antisense oligonucleotides are designed as 18-mers DNA-LNA mixmers with a

phosphorothioate backbone, DNA-LNA mixmers with a phosphorothioate backbone, LNA at the

very 5′ and 3′ position and e.g. LNA for every 2^nd or 3^rd nucleotide (see Compound table).

RefSeq

Relative

Compound

NM_002087.3
Target

luciferase

ID #
Oligonucleotide
(SEQ ID NO 1)
Site

activity

(see
Sequence Motif
Start
End
Sequence
Target
Relative

SEQ ID
Compound
(nucleobase Sequence)
Position
Position
ID
Site Sequence
to PBS)

SEQ ID
COMP ID
5′-TGCAGAGTCTTCAGTACT-3′
2044
2061
SEQ ID
AGTACTGAAGACTCTGCA
0.46

#247
247

587

SEQ ID
COMP ID
5′-GGCTGCAGAGTCTTCAGT-3′
2047
2064
SEQ ID
ACTGAAGACTCTGCAGCC
0.25

#248
248

588

SEQ ID
COMP ID
5′-GAGGGCTGCAGAGTCTTC-3′
2050
2067
SEQ ID
GAAGACTCTGCAGCCCTC
0.35

#249
249

589

SEQ ID
COMP ID
5′-CCCGAGGGCTGCAGAGTC-3′
2053
2070
SEQ ID
GACTCTGCAGCCCTCGGG
0.65

#250
250

590

SEQ ID
COMP ID
5′-GGTCCCGAGGGCTGCAGA-3′
2056
2073
SEQ ID
TCTGCAGCCCTCGGGACC
0.69

#251
251

591

SEQ ID
COMP ID
5′-TGGGGTCCCGAGGGCTGC-3′
2059
2076
SEQ ID
GCAGCCCTCGGGACCCCA
0.37

#252
252

592

SEQ ID
COMP ID
5′-GAGTGGGGTCCCGAGGGC-3′
2062
2079
SEQ ID
GCCCTCGGGACCCCACTC
0.77

#253
253

593

SEQ ID
COMP ID
5′-TCCGAGTGGGGTCCCGAG-3′
2065
2082
SEQ ID
CTCGGGACCCCACTCGGA
0.75

#254
254

594

SEQ ID
COMP ID
5′-CCCTCCGAGTGGGGTCCC-3′
2068
2085
SEQ ID
GGGACCCCACTCGGAGGG
0.67

#255
255

595

SEQ ID
COMP ID
5′-GCACCCTCCGAGTGGGGT-3′
2071
2088
SEQ ID
ACCCCACTCGGAGGGTGC
0.57

#256
256

596

SEQ ID
COMP ID
5′-AGGGCACCCTCCGAGTGG-3′
2074
2091
SEQ ID
CCACTCGGAGGGTGCCCT
0.78

#257
257

597

SEQ ID
COMP ID
5′-CAGAGGGCACCCTCCGAG-3′
2077
2094
SEQ ID
CTCGGAGGGTGCCCTCTG
0.92

#258
258

598

SEQ ID
COMP ID
5′-GAGCAGAGGGCACCCTCC-3′
2080
2097
SEQ ID
GGAGGGTGCCCTCTGCTC
0.29

#259
259

599

SEQ ID
COMP ID
5′-CCTGAGCAGAGGGCACCC-3′
2083
2100
SEQ ID
GGGTGCCCTCTGCTCAGG
0.63

#260
260

600

SEQ ID
COMP ID
5′-AGGCCTGAGCAGAGGGCA-3′
2086
2103
SEQ ID
TGCCCTCTGCTCAGGCCT
0.56

#261
261

601

SEQ ID
COMP ID
5′-GGGAGGCCTGAGCAGAGG-3′
2089
2106
SEQ ID
CCTCTGCTCAGGCCTCCC
0.74

#262
262

602

SEQ ID
COMP ID
5′-CTAGGGAGGCCTGAGCAG-3′
2092
2109
SEQ ID
CTGCTCAGGCCTCCCTAG
1.13

#263
263

603

SEQ ID
COMP ID
5′-GTGCTAGGGAGGCCTGAG-3′
2095
2112
SEQ ID
CTCAGGCCTCCCTAGCAC
0.99

#264
264

604

SEQ ID
COMP ID
5′-GAGGTGCTAGGGAGGCCT-3′
2098
2115
SEQ ID
AGGCCTCCCTAGCACCTC
0.83

#265
265

605

SEQ ID
COMP ID
5′-GGGGAGGTGCTAGGGAGG-3′
2101
2118
SEQ ID
CCTCCCTAGCACCTCCCC
0.89

#266
266

606

SEQ ID
COMP ID
5′-TAGGGGGAGGTGCTAGGG-3′
2104
2121
SEQ ID
CCCTAGCACCTCCCCCTA
1.27

#267
267

607

SEQ ID
COMP ID
5′-GGTTAGGGGGAGGTGCTA-3′
2107
2124
SEQ ID
TAGCACCTCCCCCTAACC
0.58

#268
268

608

SEQ ID
COMP ID
5′-TTTGGTTAGGGGGAGGTG-3′
2110
2127
SEQ ID
CACCTCCCCCTAACCAAA
1.09

#269
269

609

SEQ ID
COMP ID
5′-GAATTTGGTTAGGGGGAG-3′
2113
2130
SEQ ID
CTCCCCCTAACCAAATTC
1.24

#270
270

610

SEQ ID
COMP ID
5′-GGAGAATTTGGTTAGGGG-3′
2116
2133
SEQ ID
CCCCTAACCAAATTCTCC
1.05

#271
271

611

SEQ ID
COMP ID
5′-CAGGGAGAATTTGGTTAG-3′
2119
2136
SEQ ID
CTAACCAAATTCTCCCTG
1.04

#272
272

612

SEQ ID
COMP ID
5′-GTCCAGGGAGAATTTGGT-3′
2122
2139
SEQ ID
ACCAAATTCTCCCTGGAC
0.94

#273
273

613

SEQ ID
COMP ID
5′-GGGGTCCAGGGAGAATTT-3′
2125
2142
SEQ ID
AAATTCTCCCTGGACCCC
0.89

#274
274

614

SEQ ID
COMP ID
5′-AATGGGGTCCAGGGAGAA-3′
2128
2145
SEQ ID
TTCTCCCTGGACCCCATT
0.99

#275
275

615

SEQ ID
COMP ID
5′-CAGAATGGGGTCCAGGGA-3′
2131
2148
SEQ ID
TCCCTGGACCCCATTCTG
0.60

#276
276

616

SEQ ID
COMP ID
5′-GCTCAGAATGGGGTCCAG-3′
2134
2151
SEQ ID
CTGGACCCCATTCTGAGC
0.52

#277
277

617

SEQ ID
COMP ID
5′-GGAGCTCAGAATGGGGTC-3′
2137
2154
SEQ ID
GACCCCATTCTGAGCTCC
0.91

#278
278

618

SEQ ID
COMP ID
5′-TGGGGAGCTCAGAATGGG-3′
2140
2157
SEQ ID
CCCATTCTGAGCTCCCCA
1.14

#279
279

619

SEQ ID
COMP ID
5′-TGATGGGGAGCTCAGAAT-3′
2143
2160
SEQ ID
ATTCTGAGCTCCCCATCA
1.11

#280
280

620

SEQ ID
COMP ID
5′-TGGTGATGGGGAGCTCAG-3′
2156
2163
SEQ ID
CTGAGCTCCCCATCACCA
0.97

#281
281

621

SEQ ID
COMP ID
5′-CCATGGTGATGGGGAGCT-3′
2149
2166
SEQ ID
AGCTCCCCATCACCATGG
0.97

#282
282

622

SEQ ID
COMP ID
5′-CTCCCATGGTGATGGGGA-3′
2152
2169
SEQ ID
TCCCCATCACCATGGGAG
0.81

#283
283

623

SEQ ID
COMP ID
5′-CACCTCCCATGGTGATGG-3′
2155
2172
SEQ ID
CCATCACCATGGGAGGTG
0.69

#284
284

624

SEQ ID
COMP ID
5′-CCCCACCTCCCATGGTGA-3′
2158
2175
SEQ ID
TCACCATGGGAGGTGGGG
0.69

#285
285

625

SEQ ID
COMP ID
5′-AGGCCCCACCTCCCATGG-3′
2161
2178
SEQ ID
CCATGGGAGGTGGGGCCT
0.58

#286
286

626

SEQ ID
COMP ID
5′-TTGAGGCCCCACCTCCCA-3′
2164
2181
SEQ ID
TGGGAGGTGGGGCCTCAA
0.47

#287
287

627

SEQ ID
COMP ID
5′-AGATTGAGGCCCCACCTC-3′
2167
2184
SEQ ID
GAGGTGGGGCCTCAATCT
0.59

#288
288

628

SEQ ID
COMP ID
5′-CTTAGATTGAGGCCCCAC-3′
2170
2187
SEQ ID
GTGGGGCCTCAATCTAAG
0.38

#289
289

629

SEQ ID
COMP ID
5′-GGCCTTAGATTGAGGCCC-3′
2173
2190
SEQ ID
GGGCCTCAATCTAAGGCC
0.43

#290
290

630

SEQ ID
COMP ID
5′-GAAGGCCTTAGATTGAGG-3′
2176
2193
SEQ ID
CCTCAATCTAAGGCCTTC
0.76

#291
291

631

SEQ ID
COMP ID
5′-AGGGAAGGCCTTAGATTG-3′
2179
2196
SEQ ID
CAATCTAAGGCCTTCCCT
0.86

#292
292

632

SEQ ID
COMP ID
5′-GACAGGGAAGGCCTTAGA-3′
2182
2199
SEQ ID
TCTAAGGCCTTCCCTGTC
1.04

#293
293

633

SEQ ID
COMP ID
5′-TCTGACAGGGAAGGCCTT-3′
2185
2202
SEQ ID
AAGGCCTTCCCTGTCAGA
0.81

#294
294

634

SEQ ID
COMP ID
5′-CCTTCTGACAGGGAAGGC-3′
2188
2205
SEQ ID
GCCTTCCCTGTCAGAAGG
0.89

#295
295

635

SEQ ID
COMP ID
5′-CCCCCTTCTGACAGGGAA-3′
2191
2208
SEQ ID
TTCCCTGTCAGAAGGGGG
0.71

#296
296

636

SEQ ID
COMP ID
5′-CAACCCCCTTCTGACAGG-3′
2194
2211
SEQ ID
CCTGTCAGAAGGGGGTTG
0.89

#297
297

637

SEQ ID
COMP ID
5′-CCACAACCCCCTTCTGAC-3′
2197
2214
SEQ ID
GTCAGAAGGGGGTTGTGG
0.42

#298
298

638

SEQ ID
COMP ID
5′-TTGCCACAACCCCCTTCT-3′
2200
2217
SEQ ID
AGAAGGGGGTTGTGGCAA
0.88

#299
299

639

SEQ ID
COMP ID
5′-CTTTTGCCACAACCCCCT-3′
2203
2220
SEQ ID
AGGGGGTTGTGGCAAAAG
1.16

#300
300

640

SEQ ID
COMP ID
5′-TGGCTTTTGCCACAACCC-3′
2206
2223
SEQ ID
GGGTTGTGGCAAAAGCCA
1.08

#301
301

641

SEQ ID
COMP ID
5′-ATGTGGCTTTTGCCACAA-3′
2209
2226
SEQ ID
TTGTGGCAAAAGCCACAT
1.01

#302
302

642

SEQ ID
COMP ID
5′-GTAATGTGGCTTTTGCCA-3′
2212
2229
SEQ ID
TGGCAAAAGCCACATTAC
0.55

#303
303

643

SEQ ID
COMP ID
5′-CTTGTAATGTGGCTTTTG-3′
2215
2232
SEQ ID
CAAAAGCCACATTACAAG
1.01

#304
304

644

SEQ ID
COMP ID
5′-CAGCTTGTAATGTGGCTT-3′
2218
2235
SEQ ID
AAGCCACATTACAAGCTG
1.50

#305
305

645

SEQ ID
COMP ID
5′-TGGCAGCTTGTAATGTGG-3′
2221
2238
SEQ ID
CCACATTACAAGCTGCCA
0.96

#306
306

646

SEQ ID
COMP ID
5′-GGATGGCAGCTTGTAATG-3′
2224
2241
SEQ ID
CATTACAAGCTGCCATCC
0.74

#307
307

647

SEQ ID
COMP ID
5′-AGGGGATGGCAGCTTGTA-3′
2227
2244
SEQ ID
TACAAGCTGCCATCCCCT
0.84

#308
308

648

SEQ ID
COMP ID
5′-GGGAGGGGATGGCAGCTT-3′
2230
2247
SEQ ID
AAGCTGCCATCCCCTCCC
0.63

#309
309

649

SEQ ID
COMP ID
5′-ACGGGGAGGGGATGGCAG-3′
2233
2250
SEQ ID
CTGCCATCCCCTCCCCGT
0.71

#310
310

650

SEQ ID
COMP ID
5′-GAAACGGGGAGGGGATGG-3′
2236
2253
SEQ ID
CCATCCCCTCCCCGTTTC
1.06

#311
311

651

SEQ ID
COMP ID
5′-ACTGAAACGGGGAGGGGA-3′
2239
2256
SEQ ID
TCCCCTCCCCGTTTCAGT
1.08

#312
312

652

SEQ ID
COMP ID
5′-TCCACTGAAACGGGGAGG-3′
2242
2259
SEQ ID
CCTCCCCGTTTCAGTGGA
0.53

#313
313

653

SEQ ID
COMP ID
5′-GGGTCCACTGAAACGGGG-3′
2245
2262
SEQ ID
CCCCGTTTCAGTGGACCC
0.93

#314
314

654

SEQ ID
COMP ID
5′-ACAGGGTCCACTGAAACG-3′
2248
2265
SEQ ID
CGTTTCAGTGGACCCTGT
0.49

#315
315

655

SEQ ID
COMP ID
5′-GCCACAGGGTCCACTGAA-3′
2251
2268
SEQ ID
TTCAGTGGACCCTGTGGC
0.57

#316
316

656

SEQ ID
COMP ID
5′-CTGGCCACAGGGTCCACT-3′
2254
2271
SEQ ID
AGTGGACCCTGTGGCCAG
0.51

#317
317

657

SEQ ID
COMP ID
5′-CACCTGGCCACAGGGTCC-3′
2257
2274
SEQ ID
GGACCCTGTGGCCAGGTG
0.73

#318
318

658

SEQ ID
COMP ID
5′-AAGCACCTGGCCACAGGG-3′
2260
2277
SEQ ID
CCCTGTGGCCAGGTGCTT
0.43

#319
319

659

SEQ ID
COMP ID
5′-GAAAAGCACCTGGCCACA-3′
2263
2280
SEQ ID
TGTGGCCAGGTGCTTTTC
0.33

#320
320

660

SEQ ID
COMP ID
5′-AGGGAAAAGCACCTGGCC-3′
2266
2283
SEQ ID
GGCCAGGTGCTTTTCCCT
0.16

#321
321

661

SEQ ID
COMP ID
5′-GATAGGGAAAAGCACCTG-3′
2269
2286
SEQ ID
CAGGTGCTTTTCCCTATC
0.65

#322
322

662

SEQ ID
COMP ID
5′-GTGGATAGGGAAAAGCAC-3′
2272
2289
SEQ ID
GTGCTTTTCCCTATCCAC
0.54

#323
323

663

SEQ ID
COMP ID
5′-CCTGTGGATAGGGAAAAG-3′
2275
2292
SEQ ID
CTTTTCCCTATCCACAGG
0.63

#324
324

664

SEQ ID
COMP ID
5′-ACCCCTGTGGATAGGGAA-3′
2278
2295
SEQ ID
TTCCCTATCCACAGGGGT
0.29

#325
325

665

SEQ ID
COMP ID
5′-AACACCCCTGTGGATAGG-3′
2281
2298
SEQ ID
CCTATCCACAGGGGTGTT
0.62

#326
326

666

SEQ ID
COMP ID
5′-ACAAACACCCCTGTGGAT-3′
2284
2301
SEQ ID
ATCCACAGGGGTGTTTGT
1.08

#327
327

667

SEQ ID
COMP ID
5′-CACACAAACACCCCTGTG-3′
2287
2304
SEQ ID
CACAGGGGTGTTTGTGTG
0.81

#328
328

668

SEQ ID
COMP ID
5′-ACACACACAAACACCCCT-3′
2290
2307
SEQ ID
AGGGGTGTTTGTGTGTGT
0.88

#329
329

669

SEQ ID
COMP ID
5′-CGCACACACACAAACACC-3′
2293
2310
SEQ ID
GGTGTTTGTGTGTGTGCG
0.60

#330
330

670

SEQ ID
COMP ID
5′-ACGCGCACACACACAAAC-3′
2296
2313
SEQ ID
GTTTGTGTGTGTGCGCGT
0.68

#331
331

671

SEQ ID
COMP ID
5′-CACACGCGCACACACACA-3′
2299
2316
SEQ ID
TGTGTGTGTGCGCGTGTG
0.51

#332
332

672

SEQ ID
COMP ID
5′-ACGCACACGCGCACACAC-3′
2302
2319
SEQ ID
GTGTGTGCGCGTGTGCGT
0.25

#333
333

673

SEQ ID
COMP ID
5′-GAAACGCACACGCGCACA-3′
2305
2322
SEQ ID
TGTGCGCGTGTGCGTTTC
0.66

#334
334

674

SEQ ID
COMP ID
5′-ATTGAAACGCACACGCGC-3′
2308
2325
SEQ ID
GCGCGTGTGCGTTTCAAT
0.82

#335
335

675

SEQ ID
COMP ID
5′-TTTATTGAAACGCACACG-3′
2311
2328
SEQ ID
CGTGTGCGTTTCAATAAA
0.76

#336
336

676

SEQ ID
COMP ID
5′-AACTTTATTGAAACGCAC-3′
2314
2331
SEQ ID
GTGCGTTTCAATAAAGTT
0.73

#337
337

677

SEQ ID
COMP ID
5′-ACAAACTTTATTGAAACG-3′
2317
2334
SEQ ID
CGTTTCAATAAAGTTTGT
0.84

#338
338

678

SEQ ID
COMP ID
5′-TGTACAAACTTTATTGAA-3′
2320
2337
SEQ ID
TTCAATAAAGTTTGTACA
0.98

#339
339

679

SEQ ID
COMP ID
5′-AAGTGTACAAACTTTATT-3′
2323
2340
SEQ ID
AATAAAGTTTGTACACTT
0.87

#340
340

680

SEQ ID
COMP ID
5′-AGAAAGTGTACAAACTTT-3′
2326
2343
SEQ ID
AAAGTTTGTACACTTTCT
0.72

#341
341

681

SEQ ID
COMP ID
5′-TTAAGAAAGTGTACAAAC-3′
2329
2346
SEQ ID
GTTTGTACACTTTCTTAA
0.87

#342
342

682

Example 7:16-Mer Oligos Targeting the 5′ UTR

16-mer Oligos targeting 5′ UTR uORF region (SEQ ID Nos 95-136) were selected, prepared and profiled for effects on Progranulin protein expression.

H4 neuroglioma cells were seeded in 96 well plates 5000 pr well, and treated with 10 μM final concentration of compounds for 5 days in 200 μL medium.

Microglia cells were chosen for analysis because these cells produce high levels of progranulin. Reduction of progranulin in microglia cells alone is sufficient to effect inflammation, lysosomal dysfunction, and hyperproliferation in a cell-autonomous manner. Therefore, targeting microglial dysfunction caused by progranulin insufficiency represents a potential therapeutic strategy to manage neurodegeneration in Frontotemporal dementia. To study effects on Progranulin in cellular systems, H4 cells (ATCC HTB-148) a commercial available glial cell line derived from a cancer patient have been used for identifying oligonucleotides capable of increasing progranulin production.

To further use Microglia that exhibit functional characteristics similar to human microglia, including phagocytosis and cytokine-mediated inflammatory responses, and express relevant microglial markers, hiPSC derived microglia iCell® Microglia from FujiFilm Cellular Dynamics Inc. (Cat. no R1131) have been used for investigating effects of selected oligonucleotides on progranulin production.

Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364). Compound #105, #106, #110, #113 and #114 induced progranulin secretion more than 150% compared to PBS as shown in FIG. 1.

Compounds #105, #106, #110 and #114 localise on the 5′ UTR of Proganulin transcript, targeting the uORF region as shown in FIG. 2.

H4 cells were seeded in 96 well plates 5000 pr well, and treated with 10 μM final concentration of compounds for 5 days in 200 μL medium. Progranulin expression levels were evaluated in cell lysate (RIPA lysis and extraction buffer from Pierce cat. No. 89900) using the WES platform (ProteinSimple) and GRN antibody Invitrogen PA5-27275 diluted 1:25 and HPRT1 antibody ab109021 (Abcam) diluted 1:50. GRN expression was normalized to endogenous housekeeping protein HPRT1.

Compounds #106, #110, and #114 induced Progranulin in cell lysate compared to PBS as shown in FIGS. 3 and 4.

Example 8: Compound #106

hiPSC derived microglia (iCell Microglia Kit, 01279, Cat. no R1131) were seeded in 48 well plates with 100000 pr well in 500 μL, and were treated with varying concentrations of Compound #106 for 5 days.

Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364).

Compound #106 (n=3) dose-dependently induced Progranulin secretion compared to PBS as shown in FIG. 5.

Example 9:18-Mer Oligos Targeting 5′ UTR

18-mer Oligos targeting 5′ UTR uORF region (SEQ ID NOs: 207-245) were selected, prepared and profiled for effects on Progranulin protein expression.

H4 neuroglioma cells were seeded in 96 well plates 5000 pr well and treated with 10 μM final concentration of compounds for 5 days in 200 μL medium. Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364).

Compound #231 and #241 induced Progranulin secretion compared to PBS as shown in FIG. 6.

Example 10: Compound #106

The structure of Compound ID #106 (SEQ ID NO 106) inducing upregulation of Progranulin in both H4 cells and hiPSC derived Microglia cells, is shown in FIG. 7.

Example 11: Full 2′MOE and 2′oMe Modified Versions of SEQ ID NO: 106

SEQ ID NO: 106 (TGGCCAGGGATCAGGG) was tested as both a full 2′MOE modified oligo (Compound #106 full 2′MOE) and a full 2′oMe modified oligo (Compound #106 full 2′oMe).

H4 neuroglioma cells seeded in 96 well plates 5000 pr well were treated with 10 μM final concentration of compounds for 5 days in 200 μL medium. Progranulin expression levels were evaluated in media after dilution 1:8 by ELISA from Abcam (ab252364). Compound #106 and

Compound #106 full 2′MOE and Compound #106 full 2′oMe induced a ˜2-fold increase in progranulin secretion to the media compared to PBS.

Example 12: Gene Transcript Regulation by Compound #106, Compound #106 Full 2′MOE and Compound #106 Full 2′oMe

To understand the number of gene transcripts regulated by compound #106, Compound #106 full 2′MOE and Compound #106 full 2′oMe, H4 neuroglioma cells seeded in 48 well plates 15000 per well were treated with 10 μM final concentration of compounds for 5 days in 500 μL medium. mRNA was isolated using the MagNAPure 96 system (Roche) according to manufacturer's protocol. The purified mRNA were sent for gene expression array analysis at Eurofins Genomics, using Clariom™ S Arrays (ThermoFisher Scientific). Expression analysis was conducted using the QIucore Omics Explorer software, using a two-group comparison and by adjusting the FDR<0.1. The number of genes regulated more than 2-fold either up and down compared to PBS were identified. Compound #106 showed 1207 genes regulated more than 2-fold, Compound #106 full 2′oMe showed 782 genes regulated more than 2-fold, whereas Compound #106 full 2′MOE only showed 43 transcripts regulated. FIG. 9 shows that Compound #106 full 2′MOE has less off-targets compared to compound #106 and Compound #106 full 2′oMe.

The genes regulated more than 2-fold with a FDR<0.1 are shown below.

Genes regulated more than 2-fold with a FDR<0.1 following treatment with Compound #106: AATF, ABCA1, ABCC2, ABCC3, ABCG1, ABLIM3, ACAT2, ACKR3, ACSL5, ACSS3, ACTA2, ACVR1B, ADAM9, ADAMTS16, ADAMTS19, ADAMTS3, ADAMTSL4, ADGRA3, ADGRB3, ADI1, ADRBK1, ADRM1, ADSL, AFAP1, AGT, AHCY, AHI1, AHNAK2, AHR, AJAP1, AKAP6, ALCAM, ALDH1L2, ALDH3A1, ALDOA, ALDOC, ALG8, ALKBH5, ALPK2, ALYREF, AMMECR1, AMMECR1L, AMPD2, AMTN, ANGPT1, ANK3, ANKRD18A, ANKRD44, ANLN, ANO7, ANPEP, ANTXR2, ANXA1, AOAH, APCDD1, APEX1, APH1A, APOBEC3B, APOL2, APOL3, APRT, AQP1, AQP3, ARAF, ARCN1, ARHGAP11B, ARHGAP35, ARHGAP8, ARHGEF2, ARL4A, ARMC6, ARPC4, ARPC4-TTLL3, ARRDC3, ARRDC4, ARSG, ASNA1, ASNS, ASPM, ASS1, ATAD2, ATN1, ATP6AP1L, ATP6VOA1, ATP8B3, ATXN2, ATXN2L, AVEN, B4GALT5, BCAM, BCL6, BDNF, BEX1, BHLHE40, BIRC5, BLID, BLM, BMP5, BNC2, BNIP3, BNIP3L, BSG, BTAF1, BUB1B, C10orf10, C10orf107, C12orf76, C17orf89, C1RL, C1orf174, C1orf21, C1orf52, C1orf53, C20orf24, C7orf26, C7orf73, C8orf4, C8orf48, C8orf58, CA12, CA5B, CA9, CACNG4, CACYBP, CALCOCO1, CALR, CAMK4, CAPNS1, CAPZB, CASC5, CASK, CBLB, CCBL1, CCDC102B, CCDC150, CCDC163P, CCDC34, CCNA2, CCNB1, CCNB2, CCND1, CCNE2, CCPG1, CCT2, CD151, CD24, CD55, CD96, CD99, CD99, CDC20, CDC42SE1, CDC45, CDC6, CDCA5, CDCA8, CDH6, CDH8, CDK1, CDKN1A, CDKN3, CDT1, CENPA, CENPF, CENPH, CENPI, CENPM, CENPN, CENPU, CENPW, CEP128, CEP19, CEP55, CEP78, CFC1, CFH, CFI, CFL1, CHAC1, CHAC2, CHAF1B, CHMP1B, CHP1, CHST15, CKAP2, CKS2, CLEC2D, CLIC4, CLIP4, CLK2, CLMN, CLSPN, CLSTN2, CLTA, CLTB, CMTM7, CNTNAP1, CNTNAP3, CNTNAP3B, CNTNAP3B, CNTNAP3P2, COASY, COBLL1, COG7, COL1A1, COL21A1, COL3A1, COL5A2, COLEC12, COMMD3-BMI1, COPRS, COPZ1, CORIN, CORO2B, COX2, COX5A, CP, CPA4, CPD, CPSF3, CRISPLD1, CSF1, CSGALNACT1, CTBP2, CTBS, CTH, CTNND1, CTSB, CTSC, CTSL, CTSO, CUL7, CXADR, CXCL14, CXCL8, CYB5D2, CYTL1, DACT1, DBI, DBN1, DCTPP1, DDIT4, DDR2, DDX39A, DDX46, DECR1, DEDD, DEPDC1, DEPTOR, DGKD, DGKD, DGKD, DGKD, DGKD, DGKD, DHCR24, DHFR, DHRS3, DHX15, DHX9, DLGAP5, DLX1, DMKN, DOCK10, DPT, DPYD, DPYSL2, DPYSL3, DPYSL5, DSEL, DSN1, DSTN, DTNBP1, DUSP6, E2F8, EBI3, EBP, EDC4, EDEM1, EDIL3, EEF1B2, EEPD1, EFEMP2, EFTUD1, EGLN3, EGR1, EID1, EIF5, EIF5A, EIF6, ELAVL2, EMP1, ENC1, ENGASE, ENO2, ENPP1, ENPP2, ENTPD4, EPAS1, EPHX1, EPT1, ERGIC1, ERH, ERN1, ERO1A, ERRFI1, ETV1, ETV5, EXO1, EXT1, EXT1, EYA4, FAM101B, FAM111A, FAM111B, FAM114A1, FAM127B, FAM13A, FAM13C, FAM155A, FAM155A, FAM155A, FAM160A2, FAM161A, FAM162A, FAM200B, FAM20B, FAM214B, FAM219A, FAM234A, FAM46A, FAM83D, FANCA, FANCD2, FANCI, FBL, FBN1, FBXO32, FBXO36, FBXO44, FBXO7, FCHSD1, FDPS, FDX1L, FEM1C, FEM1C, FEN1, FGF7, FH, FIBIN, FJX1, FKBP10, FKBP1A, FKBP1A-SDCBP2, FKBP9, FLOT1, FLOT2, FLRT2, FN1, FNBP4, FOSL1, FOSL2, FOXF1, FOXF2, FOXK1, FOXM1, FRMD4B, FSCN1, FSTL1, FSTL4, FTSJ2, FUCA1, FUNDC2, FURIN, FUS, FUT11, FXYD5, FYCO1, GABRE, GALNT1, GALNT13, GANAB, GAR1, GATAD1, GBA, GBE1, GCLC, GCSH, GDI1, GFPT1, GFRA1, GFRA2, GINS1, GINS2, GLCCI1, GLI3, GLIPR2, GLIS3, GLRX2, GLT8D2, GLUL, GML, GMNN, GNAI1, GPAA1, GPATCH2L, GPATCH4, GPI, GPNMB, GPR137C, GPR34, GPRC5B, GPT2, GRAMD1A, GRINA, GRM8, GRWD1, GTF3A, GTPBP6, GTPBP6, H2AFV, H2AFX, H2AFY2, H6PD, HDAC9, HELLS, HGF, HIBCH, HILPDA, HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2AB, HIST1H2AG, HIST1H2AH, HIST1H2AI, HIST1H2AJ, HIST1H2AL, HIST1H2AM, HIST1H2BF, HIST1H2BG, HIST1H2BH, HIST1H2BI, HIST1H2BJ, HIST1H2BK, HIST1H2BL, HIST1H2BO, HIST1H3B, HIST1H3D, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4H, HIST1H41, HIST2H2AA3, HIST2H2AA4, HIST2H2AB, HIST2H2AC, HIST2H2BE, HIST2H2BF, HIST2H3A, HIST2H3A, HIST2H3D, HIST2H4A, HIST2H4B, HIST3H2A, HIST3H2BB, HJURP, HK2, HLTF, HMGB3, HMGCS1, HMGCS2, HNRNPM, HOXA13, HOXA3, HOXB3, HPCAL1, HS6ST2, HSD17B13, HSF4, HSP90AA1, HSPA13, HSPB3, HSPH1, HTATSF1, HTR7, ID2, ID3, IDH2, IDI1, IDO1, IER3, IFI16, IFI44L, IFITM1, IFITM2, IFITM3, IFNGR2, IGF2, IGF2BP3, IGFBP3, IGFBP5, IK, IL13RA1, IL13RA2, IL1R1, IL1RAP, IL20RB, IL32, IL6, INAFM1, INHBB, INSIG2, IRF9, ISY1, ITFG2, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA8, ITGAX, ITGB3, ITGB5, ITGB6, ITGBL1, ITM2C, ITPKB, JAK2, JAK2, JUN, KAZALD1, KCNQ3, KCTD11, KDM4C, KDM5C, KEAP1, KIAA0101, KIAA1456, KIF11, KIF14, KIF15, KIF15, KIF15, KIF15, KIF15, KIF18A, KIF20A, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KLF10, KLF9, KLHL4, KNSTRN, KNTC1, KPNA2, KPTN, KRT17, KRT81, KYNU, LACTB, LAMA1, LAMB1, LAMTOR4, LANCL2, LBH, LEF1, LEFTY2, LHX8, LIF, LIFR, LIMCH1, LINC00473, LINGO2, LMAN1, LMBR1L, LMNB1, LMNB2, LMNTD2, LOC100130880, LOX, LPAR6, LPCAT1, LPXN, LRIG3, LRP1, LRRC1, LRRC15, LRRC17, LRRC23, LRRC8C, LRRTM4, LRRTM4, LSAMP, LSG1, LSM3, LSM5, LUZP1, LY6E, LYPD6B, MAGEA1, MAP1LC3C, MAP2K6, MAP3K7CL, MAP9, MAPK14, MAPK1IP1L, MAPK3, MAPRE3, MARS, MASP1, MATN2, MBOAT7, MCAT, MCFD2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCM8, MCOLN1, MCTP2, MDH1B, MECOM, MEF2A, MEIS2, MELK, METTL15, MFAP3L, MFSD1, MFSD10, MGAT5, MGST3, MILR1, MIR99AHG, MKI67, MMAB, MMD, MMP13, MMP3, MNS1, MOCOS, MOCS2, MOGS, MORF4L2, MOSPD2, MPI, MPP7, MPPED2, MPRIP, MRPL3, MRPL51, MRPL57, MRPS11, MSANTD2, MSH2, MT1B, MT1G, MT1IP, MT1L, MT1X, MT2A, MTCH2, MTERF3, MTHFD1, MTIF2, MTPAP, MX1, MYADM, MYBL2, MYLK, MYO6, MYO6, NAGK, NALCN, NAMPT, NANOS1, NAP1L1, NAPA, NASP, NCAM1, NCAPD2, NCAPG, NCAPH, NCK1, NCKAP5, NCL, NCOA4, NCOA7, ND4L, NDC80, NDNF, NDRG1, NDUFA4L2, NDUFS6, NDUFS8, NEIL3, NETO2, NEU1, NEXN, NFAT5, NFE2, NFE2L1, NFKB2, NFKBIA, NFYB, NHEJ1, NHP2, NMI, NOL3, NPIPA1, NPIPA5, NPIPA7, NPIPA7, NPIPA8, NR2C1, NR2F1, NR4A1, NSDHL, NSMAF, NSUN4, NUAK1, NUSAP1, NXPH4, NYAP2, OAS1, OAS2, OASL, OCIAD2, ODC1, OGN, OGT, OLA1, OLFML2B, OLFML3, OR8B12, ORAI3, ORC1, ORC6, OSBPL3, OSGEP, OSMR, OXCT1, P4HA1, P4HA2, PABPC4, PAFAH1B3, PAK1IP1, PAN2, PAQR6, PARD3B, PARM1, PARP14, PCDH10, PCF11, PCMTD1, PCNA, PCNX, PCP4, PCYOX1L, PDE10A, PDE4B, PDE5A, PDGFD, PDGFRA, PDIA4, PDK1, PDLIM5, PELI1, PELO, PEPD, PFKFB4, PFKP, PGAM1, PGK1, PHF19, PHLDA1, PIDD1, PIF1, PIK3R3, PITPNM1, PITX1, PLA2G6, PLAC8, PLAGL1, PLAT, PLAU, PLD1, PLD1, PLEKHA2, PLEKHG1, PLEKHS1, PLIN2, PLK4, PLN, PLOD1, PLOD2, PLOD3, PLPP3, PLPP4, PLSCR1, PLXDC2, PLXNC1, PMEPA1, PMM2, PNPLA2, PNPLA6, PNRC1, PODXL, POLQ, POLR1E, POLR2J4, POLR3D, POMT1, PON2, POSTN, PPARGC1A, PPIL1, PPM1B, PPP1R37, PPP1R7, PPP1R8, PPP3CA, PQBP1, PRADC1, PRC1, PRH1, PRIM1, PRKAA2, PRKAB2, PRKAR1A, PRKDC, PRKG1, PROCR, PROZ, PRR4, PRRC2B, PRRT1, PRUNE2, PSAT1, PSD3, PSMA2, PSMB1, PSMD1, PSMD2, PSMD3, PSMD9, PSMG1, PSMG2, PTAR1, PTCHD1, PTGES, PTGES3L-AARSD1, PTGR2, PTGS2, PTPMT1, PTPN13, PTPRG, PTPRM, PTPRN2, PUS7L, PVRL2, QRICH2, RAB27A, RAB33B, RAB7B, RABEP2, RABGGTA, RAD51, RAD51AP1, RAD51C, RALGAPA2, RALGPS2, RANBP3L, RASA4, RASL11A, RBL1, RBL2, RBM3, RBM8A, RBPMS, RCN3, REC8, RECQL4, RELA, REPS1, RFC4, RFPL4A, RGL2, RGS10, RGS18, RGS2, RMI2, RNF144A, RNF145, RNF213, RNF24, RNPEP, RORA, RP11-307P5.1, RPP21, RPP30, RPP40, RPS26, RPS26, RPS6KA3, RRAGC, RRAS, RRBP1, RRM1, RRM2, RTKN2, RTN3, RUNX2, RWDD1, S100A10, SAFB2, SAMD15, SAMD5, SAMD8, SAT1, SATB2, SBNO2, SCAMP3, SCARA3, SCN9A, SCOC, SCRIB, SDC4, SEC14L2, SEC23B, SECISBP2L, SEL1L3, SEMA3C, SEMA4B, SEMA6D, SERHL2, SERINC5, SERPINA3, SETD5, SF3B1, SFR1, SFRP4, SGIP1, SGK1, SGOL2, SGSH, SH3BGRL3, SH3BP2, SHB, SHC1, SHC4, SHCBP1, SHISA5, SHMT1, SIDT2, SIGMAR1, SKA2, SLC14A1, SLC16A1, SLC16A1, SLC16A3, SLC16A4, SLC16A6, SLC1A3, SLC1A5, SLC20A1, SLC25A19, SLC25A36, SLC25A37, SLC26A11, SLC29A1, SLC29A4, SLC2A1, SLC2A14, SLC2A3, SLC35F5, SLC37A3, SLC43A2, SLC4A4, SLC6A6, SLC7A5, SLCO4A1, SLFN5, SLIT2, SLITRK2, SLPI, SMAD7, SMAD9, SMAGP, SMC3, SMIM3, SMOX, SMPD1, SMPDL3A, SNAI1, SNAPC3, SNED1, SNRNP25, SNRPF, SNX2, SNX33, SOBP, SOCS4, SOCS5, SORT1, SOST, SPC24, SPC25, SPDL1, SPOCD1, SPON2, SPP1, SPRY1, SPRY3, SPRY3, SPRY4, SQLE, SRM, SRPX2, SRRT, SSBP2, ST8SIA4, STAG3L4, STC1, STC2, STEAP1B, STEAP2, STEAP3, STIL, STK11IP, STRA6, STXBP5L, SURF4, SURF4, SURF4, SURF4, SUV39H1, SVIP, SYNC, SYNJ2, SYT14, SYTL2, TACC3, TADA3, TAF9, TAF9B, TAGLN2, TANGO6, TAPBP, TAS2R31, TBC1D1, TBC1D28, TBC1D31, TBL1X, TBXAS1, TCEAL2, TCEAL4, TCF19, TCHP, TCP1, TDO2, TEX264, TFAP2A, TFAP2C, TFPI, TFRC, TGFA, TGFB2, THTPA, TIMELESS, TIMM10, TIMP1, TIMP3, TIPARP, TM2D2, TM4SF1, TM9SF4, TMED4, TMED7-TICAM2, TMEM100, TMEM160, TMEM182, TMEM2, TMEM2, TMEM230, TMEM30A, TMEM39A, TMEM70, TMEM97, TMEM98, TMEM99, TMPO, TMSB15A, TMUB1, TNFRSF10B, TNFRSF1A, TNFRSF9, TNFSF10, TOE1, TOMM34, TOP2A, TOR3A, TP63, TPBG, TPCN1, TPM1, TPMT, TPX2, TRAPPC2L, TRAPPC4, TRAPPC5, TRIB2, TRIB3, TRIM22, TRIM25, TRIM36, TRIM5, TRIP10, TRIP13, TRIT1, TRMO, TROAP, TSPAN9, TSR2, TSR3, TTC25, TTC37, TTLL12, TUBG2, TVP23C, TWISTNB, TXN, TXNIP, TYMS, U2AF1, UBE2C, UBR7, UGGT2, UHRF1, UMPS, UNC93B1, UNG, USP3, VAT1, VCAM1, VCAN, VGF, VOPP1, VPS11, VRK1, VWA5A, WARS, WDR27, WDR34, WDR60, WDR62, WDR76, WDR90, WNT2B, WNT5B, WSB1, XBP1, XRCC2, XRCC3, XRCC6BP1, YEATS4, YIF1A, YY1AP1, ZBED6, ZBTB25, ZC4H2, ZDHHC15, ZDHHC4, ZNF160, ZNF326, ZNF358, ZNF382, ZNF395, ZNF414, ZNF511, ZNF512B, ZNF521, ZNF529-AS1, ZNF532, ZNF570, ZNF667, ZNF682, ZNF692, ZNF777, ZNF785, ZNF830, ZNF92, ZWILCH and ZWINT.

Genes regulated more than 2-fold with a FDR<0.1 following treatment with Compound #106 full 2′oMe: AARS, ABCA1, ABLIM1, ACAT2, ACSL5, ADAM9, ADAMTS16, ADAMTS19, ADAMTSL4, ADGRA2, ADRBK1, ADRM1, ADSSL1, AGPS, AGRN, AGT, AHNAK, AHNAK2, AHR, AJAP1, AK7, AKAP12, AKAP6, AKR1C2, AKR1C3, ALCAM, ALDH1L2, ALDH3A1, ALDOC, ALPK2, ALYREF, AMTN, ANK3, ANKRD44, ANPEP, ANTXR2, AOAH, AP4S1, APCDD1, AQP1, ARHGAP11B, ARHGDIB, ARHGEF2, ARL15, ARMC6, ARRDC3, ARRDC4, ARSG, ASPN, ATAD2, ATHL1, ATP13A2, ATP6AP1L, ATP6V1C1, ATXN1, AURKB, BANF1, BCAR3, BCAT1, BCL6, BCO1, BDNF, BEX1, BLID, BMP5, BNC2, BNIP3, BSG, BST2, BTAF1, BTG2, BTG3, BUB1, BUB1B, C10orf107, C14orf1, C14orf132, C1QTNF3, C3orf14, C3orf58, C4A, C4B, C8orf4, C9orf43, C9orf50, CA12, CA9, CACNG4, CALCB, CAMK4, CARS, CASK, CASP4, CBFA2T3, CCDC102B, CCDC34, CCNA2, CCPG1, CD24, CD55, CD82, CD96, CDC45, CDC6, CDCA3, CDCA5, CDCA8, CDH6, CDK1, CEBPG, CENPF, CENPI, CENPM, CENPN, CENPU, CEP128, CFH, CFI, CHAC1, CHEK1, CHL1, CHMP1B, CHRNA1, CHRNA9, CHST15, CLDND1, CLEC2B, CLIC2, CLIC5, CLMN, CLSTN2, CMKLR1, CMTM3, CNPPD1, CNTNAP1, CNTNAP3, CNTNAP3B, CNTNAP3B, CNTNAP3P2, COBLL1, COL1A1, COL3A1, COL5A2, COLEC12, CORIN, CP, CPA4, CSF1, CSGALNACT1, CSGALNACT2, CSNK1E, CTBP1, CTBS, CTH, CTNS, CTSC, CXADR, CXCL14, CXCL3, CXCL8, CYP51A1, CYTH3, DACT1, DACT1, DBI, DBN1, DDIT4, DDX39A, DDX58, DDX60, DECR1, DEPTOR, DET1, DGKD, DGKD, DGKD, DGKD, DGKD, DHCR24, DHCR7, DHFR, DHFR, DHRS3, DHX58, DLG3, DLGAP5, DLX1, DNAH5, DNAJB1, DOCK10, DPT, DPYSL3, DSEL, DSN1, DUSP10, DUSP6, EBP, EEPD1, EFEMP2, EFTUD1, EGLN3, EID1, EIF2AK2, ELAVL2, EMP1, ENC1, ENGASE, ENO1, ENO2, ENPP2, ENTPD4, EPAS1, ERICH1, ERO1A, ERRFI1, ETV1, EXO1, EXT1, EXT1, F3, FAM111A, FAM111B, FAM118B, FAM13A, FAM13C, FAM155A, FAM155A, FAM161A, FAM162A, FAM198B, FAM20C, FAM46A, FAM83D, FANCI, FAP, FAS, FBLN5, FBN1, FBXO32, FGF7, FJX1, FLOT1, FN1, FOXF2, FOXM1, FSTL1, FSTL4, FUT11, GABRE, GADD45A, GATAD1, GBE1, GCLC, GDF15, GDI1, GFRA1, GINS1, GINS2, GLRX, GLT8D2, GLUL, GMFG, GNAI1, GNPDA1, GPC4, GPCPD1, GPI, GPNMB, GPRC5B, GPS2, GPT2, GPX3, GRIP1, H2AFV, H2AFX, HACE1, HDAC9, HDLBP, HGF, HHAT, HIPK2, HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2AG, HIST1H2AH, HIST1H2AI, HIST1H2AJ, HIST1H2AL, HIST1H2AM, HIST1H2BF, HIST1H2BH, HIST1H2BI, HIST1H2BJ, HIST1H2BK, HIST1H2BL, HIST1H3B, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H4B, HIST1H4C, HIST1H4H, HIST2H2AA3, HIST2H2AA4, HIST2H2AB, HIST2H2AC, HIST2H2BE, HIST2H2BF, HIST2H3A, HIST2H3A, HIST2H3D, HIST2H4A, HIST2H4B, HIST3H2BB, HLA-DRA, HMCN1, HMGB3, HMGCR, HMGCS1, HMGN2, HNRNPM, HOXA3, HPCAL1, HS6ST2, HSD17B10, HSD17B13, HSF4, HSP90B1, HSPB3, HTR7, ID3, IDI1, IDO1, IER3, IFI16, IFI27, IFI44, IFI44L, IFI6, IFITM1, IFITM2, IFITM3, IGF1, IGFBP3, IGFBP5, IL13RA1, IL13RA2, IL1R1, IL20RB, IL6, IL7R, ILF2, INAFM1, INHBA, INHBB, INSIG1, INSIG2, IRF9, ITGA11, ITGA2, ITGA5, ITGA6, ITGA8, ITGAX, ITGB6, ITGBL1, ITPKB, JAK2, JUN, KBTBD11, KCNH1, KCNQ3, KIAA0101, KIAA1456, KIF11, KIF15, KIF15, KIF15, KIF20A, KIF22, KIF23, KIF26B, KIF2C, KIF4A, KIFC1, KIRREL3, KPNA2, KRT17, KRTAP9-3, KYNU, LACTB, LAMB1, LBH, LEF1, LEFTY1, LEMD1, LEPR, LFNG, LGR4, LIF, LIMCH1, LINC00473, LINC00663, LINC01565, LINGO2, LITAF, LMAN1, LMNB1, LMNB2, LOX, LPAR6, LPCAT1, LRIG3, LRRC15, LRRC23, LRRN1, LRRTM4, LSAMP, LSS, LST1, LXN, LY6E, LY6E, LYPD6B, MAP1LC3C, MAP2K6, MAP3K5, MAP3K7CL, MASP1, MB21D2, MCM2, MCM3, MCM4, MCM5, MCOLN1, MCTP2, MECOM, MEIS2, MELK, MERTK, MET, MFAP2, MFAP3L, MFAP4, MFSD10, MGLL, MGP, MILR1, MIR99AHG, MKI67, MMD, MMP13, MOCOS, MPI, MPP7, MPPED2, MSC, MSH2, MT1X, MTFR2, MTHFD1, MTIF2, MX1, MX2, MYBL2, MYLK, MYO5B, MYO6, NAMPT, NANOS1, NBL1, NBN, NCAM1, NCAPD2, NCAPG, NCKAP1, NCOA7, NDC80, NDNF, NDOR1, NDUFA4L2, NES, NEXN, NFE2, NFKBIA, NKAP, NNT, NOL3, NPAS2, NPIPA1, NPIPA5, NPIPA7, NPIPA8, NQO1, NR2F1, NREP, NTM, NUAK1, NUCB2, NUDT22, NUSAP1, NXPH4, NYAP2, OAS1, OAS2, OBFC1, OLFM1, OLFML2A, OLFML2B, OLFML3, OR5H1, OSBPL3, OSGEP, OSMR, OXCT1, P2RX7, P4HA1, PABPC1, PABPC1L2A, PADI3, PADI3, PAN2, PARM1, PARP1, PARP14, PARP9, PAX9, PCDH10, PCNA, PCNX, PCP4, PDE10A, PDE5A, PDGFD, PDGFRA, PDIK1L, PDK1, PDK2, PDLIM5, PEPD, PFKFB4, PFKP, PGK1, PHLDA1, PIDD1, PIK3R3, PITX1, PKD1, PLAC8, PLAT, PLAU, PLD1, PLD1, PLIN2, PLK1, PLK4, PLOD1, PLPP3, PLPP4, PLSCR1, PLXDC2, PMEPA1, PNPLA3, POFUT2, POLD2, POLR1E, POLR2J4, POSTN, POU6F1, PPARG, PPARGC1A, PPP1CC, PRC1, PREX2, PRICKLE1, PRIM1, PRKAA2, PRKD1, PROCR, PRR11, PRSS12, PRUNE2, PSD3, PSG4, PTCH1, PTCHD1, PTGES, PTGS2, PTPN13, PTPRM, PVRL2, PXDC1, PYROXD1, RAB27A, RAB43, RACGAP1, RAD54L, RALGAPA2, RANBP3L, RAP2B, RASL11A, RASL11B, RBL2, RBM3, RBPMS, RCN3, REC8, RELB, RGS10, RGS18, RGS2, RHOJ, RNF145, RNF217, RNFT2, RORA, RPS6KA3, RRAGC, RRM1, RTKN2, RUNX2, SAMD15, SAMD8, SAT1, SATB2, SBNO2, SC5D, SDC4, SDR42E1, SECISBP2L, SEL1L3, SEMA4B, SERINC5, SERPINB1, SERPINE2, SERTAD4, SESN3, SFRP4, SGIP1, SGK1, SGOL1, SGSH, SHC1, SHC4, SHCBP1, SHISA5, SHMT1, SIDT2, SIX1, SLC14A1, SLC16A3, SLC16A4, SLC16A6, SLC1A3, SLC20A1, SLC25A37, SLC29A1, SLC29A4, SLC2A14, SLC2A3, SLC39A8, SLC44A4, SLC4A4, SLC50A1, SLC7A5, SLC9A3R2, SLCO1C1, SLCO4A1, SLFN5, SLIT2, SLITRK2, SLPI, SMAD9, SNAI1, SNAP25, SNAPC1, SNX8, SORBS2, SORT1, SPAG4, SPC24, SPC25, SPDL1, SPECC1, SPOCD1, SPP1, SPRY1, SSBP2, ST8SIA4, STARD4, STAT1, STC1, STC2, STEAP2, STEAP3, STMN1, SULT1E1, SYNC, SYNGR1, SYNM, SYT14, TACC3, TAF9B, TBC1D2, TBC1D3L, TBL1X, TDO2, TET3, TFAP2C, TFB1M, TFPI, TFRC, TGFB2, TIMELESS, TIMP1, TIMP3, TIPARP, TK1, TLR3, TM4SF1, TMCO4, TMEM100, TMEM140, TMEM189, TMEM19, TMEM2, TMEM255A, TMEM257, TMEM97, TNC, TNFRSF10B, TNFRSF9, TNFSF10, TOB1, TOP2A, TP63, TPBG, TPM1, TPM2, TPX2, TRAPPC2L, TRIB2, TRIB3, TRIM36, TRIM49C, TSPAN2, TSPAN9, TUBA1A, TVP23C, TXK, TXNIP, TYMS, UAP1L1, UBR7, UHRF1, VASH2, VCAM1, VCAN, VEGFA, VGLL2, VWA5A, WARS, WDR60, WDR62, WDR76, WFDC3, WFS1, WNT2B, WSB1, XBP1, XRCC2, YARS, YIF1A, ZBTB25, ZFP36L2, ZNF395, ZNF521, ZNF667, ZNF804A and ZNF814.

Genes regulated more than 2-fold with a FDR<0.1 following treatment with Compound #106 full 2′MOE: ACAT2, ADI1, ARRDC4, CCPG1, CDCA5, COL3A1, CP, CXCL8, EFEMP2, ENC1, FANCD2, FBN1, HIST1H1B, HIST1H2AG, HIST1H2AI, HIST1H2AL, HIST1H2BA, HIST1H3B, HIST2H2AA4, HIST2H2BF, HIST3H2BB, HSF4, IFI44L, IFI6, IGFBP3, KHDC1, KIF20A, LEF1, LOX, LY6E, MGAT4C, MMP3, MX1, NDNF, NDUFA4L2, NUSAP1, PDGFD, PHLDA1, PTX3, RGS18, SFRP4, TPBG and VCAN.

Example 13

H4 neuroglioma cells seeded in 96 well plates 5000 pr well were treated with 10 μM final concentration of compounds for 5 days in 200 μL full growth medium. Progranulin expression levels were evaluated in the media after dilution 1:8 by ELISA from Abcam (ab252364) according to manufacturer's protocol. Progranulins levels were normalized to PBS treated cells and values above >1 therefore indicates an upregulation of PGRN protein levels. Table 4 list the compounds tested, their sequences and their corresponding target site on the PGRN mRNA as well as the Progranulin protein expression levels.

TABLE 4

All the antisense oligonucleotides are designed as 18-mers DNA-LNA mixmers with a phosphorothioate backbone, DNA-LNA mixmers

with a phosphorothioate backbone, LNA at the very 5′ and 3′ position and e.g. LNA for every 2^nd or 3^rd nucleotide (see Compound table).

Mature mRNA
Precursor-mRNA

Relative

Compound

Postion
Position

Progranulin

ID (See
Oligonucleotide
(SEQ ID NO 1)
(SEQ ID NO 3949)
Target Site

expression

Compound
Sequence Motif
Start
End
Start
Position
Sequence
Target
(Relative

SEQ ID
Table)
(nucleobase Sequence)
Position
Position
Position
End
ID
Site Sequence
to PBS)

SEQ ID
COMP ID
TTTCTAGGGATCATGTGA
10
27
10
27
SEQ ID
TCACATGATCCCTAGAAA
1.53

693
693

2321

SEQ ID
COMP ID
CATTTCTAGGGATCATGT
12
29
12
29
SEQ ID
ACATGATCCCTAGAAATG
1.17

694
694

2322

SEQ ID
COMP ID
CCCATTTCTAGGGATCAT
14
31
14
31
SEQ ID
ATGATCCCTAGAAATGGG
no data

695
695

2323

SEQ ID
COMP ID
ACCCCATTTCTAGGGATC
16
33
16
33
SEQ ID
GATCCCTAGAAATGGGGT
1.06

696
696

2324

SEQ ID
COMP ID
ACACCCCATTTCTAGGGA
18
35
18
35
SEQ ID
TCCCTAGAAATGGGGTGT
no data

697
697

2325

SEQ ID
COMP ID
CCACACCCCATTTCTAGG
20
37
20
37
SEQ ID
CCTAGAAATGGGGTGTGG
no data

698
698

2326

SEQ ID
COMP ID
CCCCACACCCCATTTCTA
22
39
22
39
SEQ ID
TAGAAATGGGGTGTGGGG
no data

699
699

2327

SEQ ID
COMP ID
CGCCCCACACCCCATTTC
24
41
24
41
SEQ ID
GAAATGGGGTGTGGGGCG
1.02

700
700

2328

SEQ ID
COMP ID
CTCGCCCCACACCCCATT
26
43
26
43
SEQ ID
AATGGGGTGTGGGGCGAG
1.03

701
701

2329

SEQ ID
COMP ID
CTCTCGCCCCACACCCCA
28
45
28
45
SEQ ID
TGGGGTGTGGGGCGAGAG
no data

702
702

2330

SEQ ID
COMP ID
TCCTCTCGCCCCACACCC
30
47
30
47
SEQ ID
GGGTGTGGGGCGAGAGGA
1.03

703
703

2331

SEQ ID
COMP ID
CTTCCTCTCGCCCCACAC
32
49
32
49
SEQ ID
GTGTGGGGCGAGAGGAAG
no data

704
704

2332

SEQ ID
COMP ID
TGCTTCCTCTCGCCCCAC
34
51
34
51
SEQ ID
GTGGGGCGAGAGGAAGCA
0.99

705
705

2333

SEQ ID
COMP ID
CCTGCTTCCTCTCGCCCC
36
53
36
53
SEQ ID
GGGGCGAGAGGAAGCAGG
1

706
706

2334

SEQ ID
COMP ID
TGGCCAGGGATCAGGGCT
139
156
139
156
SEQ ID
AGCCCTGATCCCTGGCCA
3.56

707
707

2335

SEQ ID
COMP ID
TTGGCCAGGGATCAGGGC
140
157
140
157
SEQ ID
GCCCTGATCCCTGGCCAA
2.3

708
708

2336

SEQ ID
COMP ID
ATTGGCCAGGGATCAGGG
141
158
141
158
SEQ ID
CCCTGATCCCTGGCCAAT
3.89

709
709

2337

SEQ ID
COMP ID
TGGCCAGGGATCAGGG
141
156
141
156
SEQ ID
CCCTGATCCCTGGCCA
3.9

710
710

2338

SEQ ID
COMP ID
CTGCGTCCGACTCCGCGG
232
249
232
249
SEQ ID
CCGCGGAGTCGGACGCAG
1.71

711
711

2339

SEQ ID
COMP ID
ACCTGCGTCCGACTCCGC

234
251
SEQ ID
GCGGAGTCGGACGCAGGT
1.11

712
712

2340

SEQ ID
COMP ID
CTACCTGCGTCCGACTCC

236
253
SEQ ID
GGAGTCGGACGCAGGTAG
1.27

713
713

2341

SEQ ID
COMP ID
TCCTACCTGCGTCCGACT

238
255
SEQ ID
AGTCGGACGCAGGTAGGA
1.31

714
714

2342

SEQ ID
COMP ID
TCTCCTACCTGCGTCCGA

240
257
SEQ ID
TCGGACGCAGGTAGGAGA
0.84

715
715

2343

SEQ ID
COMP ID
GCTCTCCTACCTGCGTCC

242
259
SEQ ID
GGACGCAGGTAGGAGAGC
0.99

716
716

2344

SEQ ID
COMP ID
CCGCTCTCCTACCTGCGT

244
261
SEQ ID
ACGCAGGTAGGAGAGCGG
1.17

717
717

2345

SEQ ID
COMP ID
GGCCGCTCTCCTACCTGC

246
263
SEQ ID
GCAGGTAGGAGAGCGGCC
1.16

718
718

2346

SEQ ID
COMP ID
GCGGCCGCTCTCCTACCT

248
265
SEQ ID
AGGTAGGAGAGCGGCCGC
1.38

719
719

2347

SEQ ID
COMP ID
GCGCGGCCGCTCTCCTAC

250
267
SEQ ID
GTAGGAGAGCGGCCGCGC
1.5

720
720

2348

SEQ ID
COMP ID
CTGCGCGGCCGCTCTCCT

252
269
SEQ ID
AGGAGAGCGGCCGCGCAG
1.5

721
721

2349

SEQ ID
COMP ID
GTCTGCGCGGCCGCTCTC

254
271
SEQ ID
GAGAGCGGCCGCGCAGAC
1.37

722
722

2350

SEQ ID
COMP ID
AGGTCTGCGCGGCCGCTC

256
273
SEQ ID
GAGCGGCCGCGCAGACCT
1.76

723
723

2351

SEQ ID
COMP ID
AGAGGTCTGCGCGGCCGC

258
275
SEQ ID
GCGGCCGCGCAGACCTCT
2.24

724
724

2352

SEQ ID
COMP ID
CGAGAGGTCTGCGCGGCC

260
277
SEQ ID
GGCCGCGCAGACCTCTCG
2.02

725
725

2353

SEQ ID
COMP ID
GGCGAGAGGTCTGCGCGG

262
279
SEQ ID
CCGCGCAGACCTCTCGCC
3.43

726
726

2354

SEQ ID
COMP ID
CAGGCGAGAGGTCTGCGC

264
281
SEQ ID
GCGCAGACCTCTCGCCTG
1.76

727
727

2355

SEQ ID
COMP ID
AGCAGGCGAGAGGTCTGC

266
283
SEQ ID
GCAGACCTCTCGCCTGCT
1.47

728
728

2356

SEQ ID
COMP ID
GGAGCAGGCGAGAGGTCT

268
285
SEQ ID
AGACCTCTCGCCTGCTCC
1.38

729
729

2357

SEQ ID
COMP ID
CAGGAGCAGGCGAGAGGT

270
287
SEQ ID
ACCTCTCGCCTGCTCCTG
3.25

730
730

2358

SEQ ID
COMP ID
GGCAGGAGCAGGCGAGAG

272
289
SEQ ID
CTCTCGCCTGCTCCTGCC
1.44

731
731

2359

SEQ ID
COMP ID
TGGGCAGGAGCAGGCGAG

274
291
SEQ ID
CTCGCCTGCTCCTGCCCA
3.77

732
732

2360

SEQ ID
COMP ID
CCTGGGCAGGAGCAGGCG

276
293
SEQ ID
CGCCTGCTCCTGCCCAGG
1.22

733
733

2361

SEQ ID
COMP ID
CCCCTGGGCAGGAGCAGG

278
295
SEQ ID
CCTGCTCCTGCCCAGGGG
1.37

734
734

2362

SEQ ID
COMP ID
GGCCCCTGGGCAGGAGCA

280
297
SEQ ID
TGCTCCTGCCCAGGGGCC
no data

735
735

2363

SEQ ID
COMP ID
CGGGCCCCTGGGCAGGAG

282
299
SEQ ID
CTCCTGCCCAGGGGCCCG
1.77

736
736

2364

SEQ ID
COMP ID
GGCGGGCCCCTGGGCAGG

284
301
SEQ ID
CCTGCCCAGGGGCCCGCC
1.97

737
737

2365

SEQ ID
COMP ID
CTGGCGGGCCCCTGGGCA

286
303
SEQ ID
TGCCCAGGGGCCCGCCAG
1.64

738
738

2366

SEQ ID
COMP ID
CCCTGGCGGGCCCCTGGG

288
305
SEQ ID
CCCAGGGGCCCGCCAGGG
2.19

739
739

2367

SEQ ID
COMP ID
GGCCCTGGCGGGCCCCTG

290
307
SEQ ID
CAGGGGCCCGCCAGGGCC
1.3

740
740

2368

SEQ ID
COMP ID
ATGGCCCTGGCGGGCCCC

292
309
SEQ ID
GGGGCCCGCCAGGGCCAT
2.44

741
741

2369

SEQ ID
COMP ID
ACATGGCCCTGGCGGGCC

294
311
SEQ ID
GGCCCGCCAGGGCCATGT
1.07

742
742

2370

SEQ ID
COMP ID
TCACATGGCCCTGGCGGG

296
313
SEQ ID
CCCGCCAGGGCCATGTGA
2.48

743
743

2371

SEQ ID
COMP ID
GCTCACATGGCCCTGGCG

298
315
SEQ ID
CGCCAGGGCCATGTGAGC
1.48

744
744

2372

SEQ ID
COMP ID
AAGCTCACATGGCCCTGG

300
317
SEQ ID
CCAGGGCCATGTGAGCTT
1.52

745
745

2373

SEQ ID
COMP ID
TCAAGCTCACATGGCCCT

302
319
SEQ ID
AGGGCCATGTGAGCTTGA
1.16

746
746

2374

SEQ ID
COMP ID
CTCAAGCTCACATGGCCC

303
320
SEQ ID
GGGCCATGTGAGCTTGAG
1.54

747
747

2375

SEQ ID
COMP ID
CCTCAAGCTCACATGGCC

304
321
SEQ ID
GGCCATGTGAGCTTGAGG
1.28

748
748

2376

SEQ ID
COMP ID
CTCAAGCTCACATGGC

305
320
SEQ ID
GCCATGTGAGCTTGAG
1.36

749
749

2377

SEQ ID
COMP ID
ACCTCAAGCTCACATGGC

305
322
SEQ ID
GCCATGTGAGCTTGAGGT
1.38

750
750

2378

SEQ ID
COMP ID
AACCTCAAGCTCACATGG

306
323
SEQ ID
CCATGTGAGCTTGAGGTT
1.01

751
751

2379

SEQ ID
COMP ID
GGAACCTCAAGCTCACAT

308
325
SEQ ID
ATGTGAGCTTGAGGTTCC
1.16

752
752

2380

SEQ ID
COMP ID
GGGGAACCTCAAGCTCAC

310
327
SEQ ID
GTGAGCTTGAGGTTCCCC
1.1

753
753

2381

SEQ ID
COMP ID
CAGGGGAACCTCAAGCTC

312
329
SEQ ID
GAGCTTGAGGTTCCCCTG
0.89

754
754

2382

SEQ ID
COMP ID
TCCAGGGGAACCTCAAGC

314
331
SEQ ID
GCTTGAGGTTCCCCTGGA
0.74

755
755

2383

SEQ ID
COMP ID
ACTCCAGGGGAACCTCAA

316
333
SEQ ID
TTGAGGTTCCCCTGGAGT
1.03

756
756

2384

SEQ ID
COMP ID
AGACTCCAGGGGAACCTC

318
335
SEQ ID
GAGGTTCCCCTGGAGTCT
0.94

757
757

2385

SEQ ID
COMP ID
TGAGACTCCAGGGGAACC

320
337
SEQ ID
GGTTCCCCTGGAGTCTCA
1.61

758
758

2386

SEQ ID
COMP ID
GCTGAGACTCCAGGGGAA

322
339
SEQ ID
TTCCCCTGGAGTCTCAGC
3.32

759
759

2387

SEQ ID
COMP ID
CGGCTGAGACTCCAGGGG

324
341
SEQ ID
CCCCTGGAGTCTCAGCCG
3.72

760
760

2388

SEQ ID
COMP ID
TCCGGCTGAGACTCCAGG

326
343
SEQ ID
CCTGGAGTCTCAGCCGGA
1.61

761
761

2389

SEQ ID
COMP ID
TCTCCGGCTGAGACTCCA

328
345
SEQ ID
TGGAGTCTCAGCCGGAGA
1.27

762
762

2390

SEQ ID
COMP ID
TGTCTCCGGCTGAGACTC

330
347
SEQ ID
GAGTCTCAGCCGGAGACA
no data

763
763

2391

SEQ ID
COMP ID
GTTGTCTCCGGCTGAGAC

332
349
SEQ ID
GTCTCAGCCGGAGACAAC
1.35

764
764

2392

SEQ ID
COMP ID
CTGTTGTCTCCGGCTGAG

334
351
SEQ ID
CTCAGCCGGAGACAACAG
1.43

765
765

2393

SEQ ID
COMP ID
TTCTGTTGTCTCCGGCTG

336
353
SEQ ID
CAGCCGGAGACAACAGAA
1.5

766
766

2394

SEQ ID
COMP ID
TCTTCTGTTGTCTCCGGC

338
355
SEQ ID
GCCGGAGACAACAGAAGA
1.08

767
767

2395

SEQ ID
COMP ID
GTTCTTCTGTTGTCTCCG

340
357
SEQ ID
CGGAGACAACAGAAGAAC
1.11

768
768

2396

SEQ ID
COMP ID
CGGTTCTTCTGTTGTCTC

342
359
SEQ ID
GAGACAACAGAAGAACCG
1.23

769
769

2397

SEQ ID
COMP ID
AGCGGTTCTTCTGTTGTC

344
361
SEQ ID
GACAACAGAAGAACCGCT
1.44

770
770

2398

SEQ ID
COMP ID
TAAGCGGTTCTTCTGTTG

346
363
SEQ ID
CAACAGAAGAACCGCTTA
1.43

771
771

2399

SEQ ID
COMP ID
AGTAAGCGGTTCTTCTGT

348
365
SEQ ID
ACAGAAGAACCGCTTACT
1.33

772
772

2400

SEQ ID
COMP ID
TCAGTAAGCGGTTCTTCT

350
367
SEQ ID
AGAAGAACCGCTTACTGA
1.16

773
773

2401

SEQ ID
COMP ID
TTTCAGTAAGCGGTTCTT

352
369
SEQ ID
AAGAACCGCTTACTGAAA
0.96

774
774

2402

SEQ ID
COMP ID
AGTTTCAGTAAGCGGTTC

354
371
SEQ ID
GAACCGCTTACTGAAACT
1.5

775
775

2403

SEQ ID
COMP ID
GGAGTTTCAGTAAGCGGT

356
373
SEQ ID
ACCGCTTACTGAAACTCC
1.46

776
776

2404

SEQ ID
COMP ID
AAGGAGTTTCAGTAAGCG

358
375
SEQ ID
CGCTTACTGAAACTCCTT
1.38

777
777

2405

SEQ ID
COMP ID
CCAAGGAGTTTCAGTAAG

360
377
SEQ ID
CTTACTGAAACTCCTTGG
1.29

778
778

2406

SEQ ID
COMP ID
CCCCAAGGAGTTTCAGTA

362
379
SEQ ID
TACTGAAACTCCTTGGGG
1.37

779
779

2407

SEQ ID
COMP ID
ACCCCCAAGGAGTTTCAG

364
381
SEQ ID
CTGAAACTCCTTGGGGGT
1

780
780

2408

SEQ ID
COMP ID
GAACCCCCAAGGAGTTTC

366
383
SEQ ID
GAAACTCCTTGGGGGTTC
0.89

781
781

2409

SEQ ID
COMP ID
CAGAACCCCCAAGGAGTT

368
385
SEQ ID
AACTCCTTGGGGGTTCTG
1.22

782
782

2410

SEQ ID
COMP ID
ATCAGAACCCCCAAGGAG

370
387
SEQ ID
CTCCTTGGGGGTTCTGAT
1.07

783
783

2411

SEQ ID
COMP ID
GTATCAGAACCCCCAAGG

372
389
SEQ ID
CCTTGGGGGTTCTGATAC
0.9

784
784

2412

SEQ ID
COMP ID
GTGTATCAGAACCCCCAA

374
391
SEQ ID
TTGGGGGTTCTGATACAC
1.05

785
785

2413

SEQ ID
COMP ID
TAGTGTATCAGAACCCCC

376
393
SEQ ID
GGGGGTTCTGATACACTA
1.02

786
786

2414

SEQ ID
COMP ID
CCTAGTGTATCAGAACCC

378
395
SEQ ID
GGGTTCTGATACACTAGG
1.17

787
787

2415

SEQ ID
COMP ID
CCCCTAGTGTATCAGAAC

380
397
SEQ ID
GTTCTGATACACTAGGGG
1.2

788
788

2416

SEQ ID
COMP ID
TCCCCCTAGTGTATCAGA

382
399
SEQ ID
TCTGATACACTAGGGGGA
0.94

789
789

2417

SEQ ID
COMP ID
ACTCCCCCTAGTGTATCA

384
401
SEQ ID
TGATACACTAGGGGGAGT
1.08

790
790

2418

SEQ ID
COMP ID
AAACTCCCCCTAGTGTAT

386
403
SEQ ID
ATACACTAGGGGGAGTTT
1

791
791

2419

SEQ ID
COMP ID
TAAAACTCCCCCTAGTGT

388
405
SEQ ID
ACACTAGGGGGAGTTTTA
0.64

792
792

2420

SEQ ID
COMP ID
CATAAAACTCCCCCTAGT

390
407
SEQ ID
ACTAGGGGGAGTTTTATG
1.26

793
793

2421

SEQ ID
COMP ID
CCCATAAAACTCCCCCTA

392
409
SEQ ID
TAGGGGGAGTTTTATGGG
0.8

794
794

2422

SEQ ID
COMP ID
TTCCCATAAAACTCCCCC

394
411
SEQ ID
GGGGGAGTTTTATGGGAA
0.99

795
795

2423

SEQ ID
COMP ID
CTTTCCCATAAAACTCCC

396
413
SEQ ID
GGGAGTTTTATGGGAAAG
1.31

796
796

2424

SEQ ID
COMP ID
CTCTTTCCCATAAAACTC

398
415
SEQ ID
GAGTTTTATGGGAAAGAG
1.44

797
797

2425

SEQ ID
COMP ID
TCCTCTTTCCCATAAAAC

400
417
SEQ ID
GTTTTATGGGAAAGAGGA
1.89

798
798

2426

SEQ ID
COMP ID
CTTCCTCTTTCCCATAAA

402
419
SEQ ID
TTTATGGGAAAGAGGAAG
1.25

799
799

2427

SEQ ID
COMP ID
TGCTTCCTCTTTCCCATA

404
421
SEQ ID
TATGGGAAAGAGGAAGCA
3.2

800
800

2428

SEQ ID
COMP ID
ACTGCTTCCTCTTTCCCA

406
423
SEQ ID
TGGGAAAGAGGAAGCAGT
1.68

801
801

2429

SEQ ID
COMP ID
TTACTGCTTCCTCTTTCC

408
425
SEQ ID
GGAAAGAGGAAGCAGTAA
1.7

802
802

2430

SEQ ID
COMP ID
AATTACTGCTTCCTCTTT

410
427
SEQ ID
AAAGAGGAAGCAGTAATT
2.78

803
803

2431

SEQ ID
COMP ID
GCAATTACTGCTTCCTCT

412
429
SEQ ID
AGAGGAAGCAGTAATTGC
3.72

804
804

2432

SEQ ID
COMP ID
CTGCAATTACTGCTTCCT

414
431
SEQ ID
AGGAAGCAGTAATTGCAG
1.17

805
805

2433

SEQ ID
COMP ID
CACTGCAATTACTGCTTC

416
433
SEQ ID
GAAGCAGTAATTGCAGTG
1.22

806
806

2434

SEQ ID
COMP ID
GTCACTGCAATTACTGCT

418
435
SEQ ID
AGCAGTAATTGCAGTGAC
1.87

807
807

2435

SEQ ID
COMP ID
GCGTCACTGCAATTACTG

420
437
SEQ ID
CAGTAATTGCAGTGACGC
1.03

808
808

2436

SEQ ID
COMP ID
GGGCGTCACTGCAATTAC

422
439
SEQ ID
GTAATTGCAGTGACGCCC
1.46

809
809

2437

SEQ ID
COMP ID
CGGGGCGTCACTGCAATT

424
441
SEQ ID
AATTGCAGTGACGCCCCG
1.2

810
810

2438

SEQ ID
COMP ID
AACGGGGCGTCACTGCAA

426
443
SEQ ID
TTGCAGTGACGCCCCGTT
1.39

811
811

2439

SEQ ID
COMP ID
CTAACGGGGCGTCACTGC

428
445
SEQ ID
GCAGTGACGCCCCGTTAG
3.79

812
812

2440

SEQ ID
COMP ID
TTCTAACGGGGCGTCACT

430
447
SEQ ID
AGTGACGCCCCGTTAGAA
1.79

813
813

2441

SEQ ID
COMP ID
CCTTCTAACGGGGCGTCA

432
449
SEQ ID
TGACGCCCCGTTAGAAGG
1.76

814
814

2442

SEQ ID
COMP ID
CCCCTTCTAACGGGGCGT

434
451
SEQ ID
ACGCCCCGTTAGAAGGGG
1.36

315
815

2443

SEQ ID
COMP ID
AGCCCCTTCTAACGGGGC

436
453
SEQ ID
GCCCCGTTAGAAGGGGCT
3.19

816
816

2444

SEQ ID
COMP ID
AAAGCCCCTTCTAACGGG

438
455
SEQ ID
CCCGTTAGAAGGGGCTTT
1.06

817
817

2445

SEQ ID
COMP ID
AGAAAGCCCCTTCTAACG

440
457
SEQ ID
CGTTAGAAGGGGCTTTCT
1.6

818
818

2446

SEQ ID
COMP ID
GTAGAAAGCCCCTTCTAA

442
459
SEQ ID
TTAGAAGGGGCTTTCTAC
2.25

819
819

2447

SEQ ID
COMP ID
AGGTAGAAAGCCCCTTCT

444
461
SEQ ID
AGAAGGGGCTTTCTACCT
1.29

820
820

2448

SEQ ID
COMP ID
GGAGGTAGAAAGCCCCTT

446
463
SEQ ID
AAGGGGCTTTCTACCTCC
1.43

821
821

2449

SEQ ID
COMP ID
GGGGAGGTAGAAAGCCCC

448
465
SEQ ID
GGGGCTTTCTACCTCCCC
1.64

822
822

2450

SEQ ID
COMP ID
CTGGGGAGGTAGAAAGCC

450
467
SEQ ID
GGCTTTCTACCTCCCCAG
2.6

823
823

2451

SEQ ID
COMP ID
TGCTGGGGAGGTAGAAAG

452
469
SEQ ID
CTTTCTACCTCCCCAGCA
3.42

824
824

2452

SEQ ID
COMP ID
AATGCTGGGGAGGTAGAA

454
471
SEQ ID
TTCTACCTCCCCAGCATT
2.21

825
825

2453

SEQ ID
COMP ID
GGAATGCTGGGGAGGTAG

456
473
SEQ ID
CTACCTCCCCAGCATTCC
2.43

826
826

2454

SEQ ID
COMP ID
GGGGAATGCTGGGGAGGT

458
475
SEQ ID
ACCTCCCCAGCATTCCCC
1.6

827
827

2455

SEQ ID
COMP ID
TGGGGGAATGCTGGGGAG

460
477
SEQ ID
CTCCCCAGCATTCCCCCA
3.44

828
828

2456

SEQ ID
COMP ID
TTTGGGGGAATGCTGGGG

462
479
SEQ ID
CCCCAGCATTCCCCCAAA
1.07

829
829

2457

SEQ ID
COMP ID
GCTTTGGGGGAATGCTGG

464
481
SEQ ID
CCAGCATTCCCCCAAAGC
2.17

830
830

2458

SEQ ID
COMP ID
CTGCTTTGGGGGAATGCT

466
483
SEQ ID
AGCATTCCCCCAAAGCAG
1.98

831
831

2459

SEQ ID
COMP ID
CCCTGCTTTGGGGGAATG

468
485
SEQ ID
CATTCCCCCAAAGCAGGG
1.31

832
832

2460

SEQ ID
COMP ID
GTCCCTGCTTTGGGGGAA

470
487
SEQ ID
TTCCCCCAAAGCAGGGAC
1.51

833
833

2461

SEQ ID
COMP ID
TGGTCCCTGCTTTGGGGG

472
489
SEQ ID
CCCCCAAAGCAGGGACCA
1.4

834
834

2462

SEQ ID
COMP ID
TGTGGTCCCTGCTTTGGG

474
491
SEQ ID
CCCAAAGCAGGGACCACA
3.59

835
835

2463

SEQ ID
COMP ID
GGTGTGGTCCCTGCTTTG

476
493
SEQ ID
CAAAGCAGGGACCACACC
3.28

836
836

2464

SEQ ID
COMP ID
ATGGTGTGGTCCCTGCTT

478
495
SEQ ID
AAGCAGGGACCACACCAT
2.45

837
837

2465

SEQ ID
COMP ID
GAATGGTGTGGTCCCTGC

480
497
SEQ ID
GCAGGGACCACACCATTC
2.59

838
838

2466

SEQ ID
COMP ID
AGAATGGTGTGGTCCCTG

481
498
SEQ ID
CAGGGACCACACCATTCT
2.2

839
839

2467

SEQ ID
COMP ID
GAATGGTGTGGTCCCT

482
497
SEQ ID
AGGGACCACACCATTC
2.02

840
840

2468

SEQ ID
COMP ID
AAGAATGGTGTGGTCCCT

482
499
SEQ ID
AGGGACCACACCATTCTT
1.64

841
841

2469

SEQ ID
COMP ID
CAAGAATGGTGTGGTCCC

483
500
SEQ ID
GGGACCACACCATTCTTG
1.99

842
842

2470

SEQ ID
COMP ID
TCAAGAATGGTGTGGTCC

484
501
SEQ ID
GGACCACACCATTCTTGA
2.61

843
843

2471

SEQ ID
COMP ID
CAAGAATGGTGTGGTC

485
500
SEQ ID
GACCACACCATTCTTG
2.61

844
844

2472

SEQ ID
COMP ID
GTCAAGAATGGTGTGGTC

485
502
SEQ ID
GACCACACCATTCTTGAC
2.79

845
845

2473

SEQ ID
COMP ID
GGTCAAGAATGGTGTGGT

486
503
SEQ ID
ACCACACCATTCTTGACC
1.99

846
846

2474

SEQ ID
COMP ID
GGGTCAAGAATGGTGTGG

487
504
SEQ ID
CCACACCATTCTTGACCC
3.09

847
847

2475

SEQ ID
COMP ID
GGTCAAGAATGGTGTG

488
503
SEQ ID
CACACCATTCTTGACC
1.65

848
848

2476

SEQ ID
COMP ID
TGGGTCAAGAATGGTGTG

488
505
SEQ ID
CACACCATTCTTGACCCA
2.16

849
849

2477

SEQ ID
COMP ID
GCTGGGTCAAGAATGGTG

490
507
SEQ ID
CACCATTCTTGACCCAGC
1.94

850
850

2478

SEQ ID
COMP ID
GAGCTGGGTCAAGAATGG

492
509
SEQ ID
CCATTCTTGACCCAGCTC
1.28

851
851

2479

SEQ ID
COMP ID
TGGAGCTGGGTCAAGAAT

494
511
SEQ ID
ATTCTTGACCCAGCTCCA
0.97

852
852

2480

SEQ ID
COMP ID
GGTGGAGCTGGGTCAAGA

496
513
SEQ ID
TCTTGACCCAGCTCCACC
1.37

853
853

2481

SEQ ID
COMP ID
GGGGTGGAGCTGGGTCAA

498
515
SEQ ID
TTGACCCAGCTCCACCCC
3.35

854
854

2482

SEQ ID
COMP ID
CAGGGGTGGAGCTGGGTC

500
517
SEQ ID
GACCCAGCTCCACCCCTG
2.53

855
855

2483

SEQ ID
COMP ID
GACAGGGGTGGAGCTGGG

502
519
SEQ ID
CCCAGCTCCACCCCTGTC
1.83

856
856

2484

SEQ ID
COMP ID
CCGACAGGGGTGGAGCTG

504
521
SEQ ID
CAGCTCCACCCCTGTCGG
3.06

857
857

2485

SEQ ID
COMP ID
TACCGACAGGGGTGGAGC

506
523
SEQ ID
GCTCCACCCCTGTCGGTA
0.99

858
858

2486

SEQ ID
COMP ID
CCTACCGACAGGGGTGGA

508
525
SEQ ID
TCCACCCCTGTCGGTAGG
2.78

859
859

2487

SEQ ID
COMP ID
CACCTACCGACAGGGGTG

510
527
SEQ ID
CACCCCTGTCGGTAGGTG
0.99

860
860

2488

SEQ ID
COMP ID
AGCACCTACCGACAGGGG

512
529
SEQ ID
CCCCTGTCGGTAGGTGCT
1.89

861
861

2489

SEQ ID
COMP ID
CCAGCACCTACCGACAGG

514
531
SEQ ID
CCTGTCGGTAGGTGCTGG
1.45

862
862

2490

SEQ ID
COMP ID
AGCCAGCACCTACCGACA

516
533
SEQ ID
TGTCGGTAGGTGCTGGCT
1.36

863
863

2491

SEQ ID
COMP ID
GAAGCCAGCACCTACCGA

518
535
SEQ ID
TCGGTAGGTGCTGGCTTC
1.44

864
864

2492

SEQ ID
COMP ID
AAGAAGCCAGCACCTACC

520
537
SEQ ID
GGTAGGTGCTGGCTTCTT
1.37

865
865

2493

SEQ ID
COMP ID
GGAAGAAGCCAGCACCTA

522
539
SEQ ID
TAGGTGCTGGCTTCTTCC
3.34

866
866

2494

SEQ ID
COMP ID
GGGGAAGAAGCCAGCACC

524
541
SEQ ID
GGTGCTGGCTTCTTCCCC
2.17

867
867

2495

SEQ ID
COMP ID
GAGGGGAAGAAGCCAGCA

526
543
SEQ ID
TGCTGGCTTCTTCCCCTC
3.05

868
868

2496

SEQ ID
COMP ID
GAGAGGGGAAGAAGCCAG

528
545
SEQ ID
CTGGCTTCTTCCCCTCTC
4.04

869
869

2497

SEQ ID
COMP ID
AGGAGAGGGGAAGAAGCC

530
547
SEQ ID
GGCTTCTTCCCCTCTCCT
1.08

870
870

2498

SEQ ID
COMP ID
CCAGGAGAGGGGAAGAAG

532
549
SEQ ID
CTTCTTCCCCTCTCCTGG
2.49

871
871

2499

SEQ ID
COMP ID
CACCAGGAGAGGGGAAGA

534
551
SEQ ID
TCTTCCCCTCTCCTGGTG
0.99

872
872

2500

SEQ ID
COMP ID
ACCACCAGGAGAGGGGAA

536
553
SEQ ID
TTCCCCTCTCCTGGTGGT
1.81

873
873

2501

SEQ ID
COMP ID
CCACCACCAGGAGAGGGG

538
555
SEQ ID
CCCCTCTCCTGGTGGTGG
1.65

874
874

2502

SEQ ID
COMP ID
CACCACCACCAGGAGAGG

540
557
SEQ ID
CCTCTCCTGGTGGTGGTG
1.2

875
875

2503

SEQ ID
COMP ID
CCCACCACCACCAGGAGA

542
559
SEQ ID
TCTCCTGGTGGTGGTGGG
1.69

876
876

2504

SEQ ID
COMP ID
CACCCACCACCACCAGGA

544
561
SEQ ID
TCCTGGTGGTGGTGGGTG
1.16

877
877

2505

SEQ ID
COMP ID
ACCACCCACCACCACCAG

546
563
SEQ ID
CTGGTGGTGGTGGGTGGT
3.65

878
878

2506

SEQ ID
COMP ID
GAACCACCCACCACCACC

548
565
SEQ ID
GGTGGTGGTGGGTGGTTC
2.58

879
879

2507

SEQ ID
COMP ID
GGGAACCACCCACCACCA

550
567
SEQ ID
TGGTGGTGGGTGGTTCCC
2.19

880
880

2508

SEQ ID
COMP ID
GCGGGAACCACCCACCAC

552
569
SEQ ID
GTGGTGGGTGGTTCCCGC
2.9

881
881

2509

SEQ ID
COMP ID
CCTCCTGTTTACCCTAAA

999
1016
SEQ ID
TTTAGGGTAAACAGGAGG
1.02

882
882

2510

SEQ ID
COMP ID
CCCCTCCTGTTTACCCTA

1001
1018
SEQ ID
TAGGGTAAACAGGAGGGG
2.58

883
883

2511

SEQ ID
COMP ID
GGCCCCTCCTGTTTACCC

1003
1020
SEQ ID
GGGTAAACAGGAGGGGCC
1.09

884
884

2512

SEQ ID
COMP ID
GTGGCCCCTCCTGTTTAC

1005
1022
SEQ ID
GTAAACAGGAGGGGCCAC
2.42

885
885

2513

SEQ ID
COMP ID
ATGTGGCCCCTCCTGTTT

1007
1024
SEQ ID
AAACAGGAGGGGCCACAT
1.39

886
886

2514

SEQ ID
COMP ID
GCATGTGGCCCCTCCTGT

1009
1026
SEQ ID
ACAGGAGGGGCCACATGC
1.64

887
887

2515

SEQ ID
COMP ID
GTGCATGTGGCCCCTCCT

1011
1028
SEQ ID
AGGAGGGGCCACATGCAC
1.97

888
888

2516

SEQ ID
COMP ID
CTGTGCATGTGGCCCCTC

1013
1030
SEQ ID
GAGGGGCCACATGCACAG
0.96

889
889

2517

SEQ ID
COMP ID
ACCTGTGCATGTGGCCCC

1015
1032
SEQ ID
GGGGCCACATGCACAGGT
4.64

890
890

2518

SEQ ID
COMP ID
TTACCTGTGCATGTGGCC

1017
1034
SEQ ID
GGCCACATGCACAGGTAA
1.75

891
891

2519

SEQ ID
COMP ID
AATTACCTGTGCATGTGG

1019
1036
SEQ ID
CCACATGCACAGGTAATT
1.65

892
892

2520

SEQ ID
COMP ID
TGAATTACCTGTGCATGT

1021
1038
SEQ ID
ACATGCACAGGTAATTCA
2.75

893
893

2521

SEQ ID
COMP ID
GGTGAATTACCTGTGCAT

1023
1040
SEQ ID
ATGCACAGGTAATTCACC
1.08

894
894

2522

SEQ ID
COMP ID
CTGGTGAATTACCTGTGC

1025
1042
SEQ ID
GCACAGGTAATTCACCAG
2.77

895
895

2523

SEQ ID
COMP ID
CCCTGGTGAATTACCTGT

1027
1044
SEQ ID
ACAGGTAATTCACCAGGG
1.25

896
896

2524

SEQ ID
COMP ID
CTCCCTGGTGAATTACCT

1029
1046
SEQ ID
AGGTAATTCACCAGGGAG
2.17

897
897

2525

SEQ ID
COMP ID
GGCTCCCTGGTGAATTAC

1031
1048
SEQ ID
GTAATTCACCAGGGAGCC
1.49

898
898

2526

SEQ ID
COMP ID
TCGGCTCCCTGGTGAATT

1033
1050
SEQ ID
AATTCACCAGGGAGCCGA
1

899
899

2527

SEQ ID
COMP ID
GTTCGGCTCCCTGGTGAA

1035
1052
SEQ ID
TTCACCAGGGAGCCGAAC
1.21

900
900

2528

SEQ ID
COMP ID
GTGTTCGGCTCCCTGGTG

1037
1054
SEQ ID
CACCAGGGAGCCGAACAC
no data

901
901

2529

SEQ ID
COMP ID
GAGTGTTCGGCTCCCTGG

1039
1056
SEQ ID
CCAGGGAGCCGAACACTC
0.95

902
902

2530

SEQ ID
COMP ID
AGGAGTGTTCGGCTCCCT

1041
1058
SEQ ID
AGGGAGCCGAACACTCCT
1.27

903
903

2531

SEQ ID
COMP ID
ACAGGAGTGTTCGGCTCC

1043
1060
SEQ ID
GGAGCCGAACACTCCTGT
no data

904
904

2532

SEQ ID
COMP ID
GCACAGGAGTGTTCGGCT

1045
1062
SEQ ID
AGCCGAACACTCCTGTGC
1.17

905
905

2533

SEQ ID
COMP ID
TGGATACCACTGCGGGGG

1327
1344
SEQ ID
CCCCCGCAGTGGTATCCA
4.37

906
906

2534

SEQ ID
COMP ID
TGTGGATACCACTGCGGG

1329
1346
SEQ ID
CCCGCAGTGGTATCCACA
1.46

907
907

2535

SEQ ID
COMP ID
GGTGTGGATACCACTGCG

1331
1348
SEQ ID
CGCAGTGGTATCCACACC
1.33

908
908

2536

SEQ ID
COMP ID
TGGGAATGGTGCAACAGG

1472
1489
SEQ ID
CCTGTTGCACCATTCCCA
1.8

909
909

2537

SEQ ID
COMP ID
CCTGGGAATGGTGCAACA

1474
1491
SEQ ID
TGTTGCACCATTCCCAGG
1.31

910
910

2538

SEQ ID
COMP ID
TGCCTGGGAATGGTGCAA

1476
1493
SEQ ID
TTGCACCATTCCCAGGCA
no data

911
911

2539

SEQ ID
COMP ID
AGTGCCTGGGAATGGTGC

1478
1495
SEQ ID
GCACCATTCCCAGGCACT
1.25

912
912

2540

SEQ ID
COMP ID
ACACCTATAACACGTCAC

1578
1595
SEQ ID
GTGACGTGTTATAGGTGT
1.1

913
913

2541

SEQ ID
COMP ID
GGACACCTATAACACGTC

1580
1597
SEQ ID
GACGTGTTATAGGTGTCC
1.15

914
914

2542

SEQ ID
COMP ID
AGGGACACCTATAACACG

1582
1599
SEQ ID
CGTGTTATAGGTGTCCCT
0.95

915
915

2543

SEQ ID
COMP ID
CAGCCGACATGTCATTTC

1736
1753
SEQ ID
GAAATGACATGTCGGCTG
1.69

916
916

2544

SEQ ID
COMP ID
CCCAGCCGACATGTCATT

1738
1755
SEQ ID
AATGACATGTCGGCTGGG
no data

917
917

2545

SEQ ID
COMP ID
CGCCCAGCCGACATGTCA

1740
1757
SEQ ID
TGACATGTCGGCTGGGCG
1.53

918
918

2546

SEQ ID
COMP ID
CACGCCCAGCCGACATGT

1742
1759
SEQ ID
ACATGTCGGCTGGGCGTG
1.27

919
919

2547

SEQ ID
COMP ID
ACCACGCCCAGCCGACAT

1744
1761
SEQ ID
ATGTCGGCTGGGCGTGGT
0.96

920
920

2548

SEQ ID
COMP ID
ATGGCATTTCTTTTTCTT

2048
2065
SEQ ID
AAGAAAAAGAAATGCCAT
1.2

921
921

2549

SEQ ID
COMP ID
ACATGGCATTTCTTTTTC

2050
2067
SEQ ID
GAAAAAGAAATGCCATGT
1.38

922
922

2550

SEQ ID
COMP ID
TTACATGGCATTTCTTTT

2052
2069
SEQ ID
AAAAGAAATGCCATGTAA
1.17

923
923

2551

SEQ ID
COMP ID
ATTTACATGGCATTTCTT

2054
2071
SEQ ID
AAGAAATGCCATGTAAAT
no data

924
924

2552

SEQ ID
COMP ID
GGCTTACGATGGGTGCAT

2135
2152
SEQ ID
ATGCACCCATCGTAAGCC
1.28

925
925

2553

SEQ ID
COMP ID
TAGGCTTACGATGGGTGC

2137
2154
SEQ ID
GCACCCATCGTAAGCCTA
1.6

926
926

2554

SEQ ID
COMP ID
GTTAGGCTTACGATGGGT

2139
2156
SEQ ID
ACCCATCGTAAGCCTAAC
3.46

927
927

2555

SEQ ID
COMP ID
TAGTTAGGCTTACGATGG

2141
2158
SEQ ID
CCATCGTAAGCCTAACTA
1.89

928
928

2556

SEQ ID
COMP ID
AAAAAACCCCTGAAAATG

2185
2202
SEQ ID
CATTTTCAGGGGTTTTTT
1.08

929
929

2557

SEQ ID
COMP ID
CAAAAAAACCCCTGAAAA

2187
2204
SEQ ID
TTTTCAGGGGTTTTTTTG
0.76

930
930

2558

SEQ ID
COMP ID
AACAAAAAAACCCCTGAA

2189
2206
SEQ ID
TTCAGGGGTTTTTTTGTT
0.89

931
931

2559

SEQ ID
COMP ID
ATATATTGGGCGCGGTGG

2487
2504
SEQ ID
CCACCGCGCCCAATATAT
3.89

932
932

2560

SEQ ID
COMP ID
AAATATATTGGGCGCGGT

2489
2506
SEQ ID
ACCGCGCCCAATATATTT
4.84

933
933

2561

SEQ ID
COMP ID
CAAAATATATTGGGCGCG

2491
2508
SEQ ID
CGCGCCCAATATATTTTG
3.54

934
934

2562

SEQ ID
COMP ID
ATCAAAATATATTGGGCG

2493
2510
SEQ ID
CGCCCAATATATTTTGAT
1.46

935
935

2563

SEQ ID
COMP ID
TAAGTACAGTCAGCCCTC

2526
2543
SEQ ID
GAGGGCTGACTGTACTTA
0.96

936
936

2564

SEQ ID
COMP ID
GTTAAGTACAGTCAGCCC

2528
2545
SEQ ID
GGGCTGACTGTACTTAAC
1.05

937
937

2565

SEQ ID
COMP ID
ATGTTAAGTACAGTCAGC

2530
2547
SEQ ID
GCTGACTGTACTTAACAT
1.19

938
938

2566

SEQ ID
COMP ID
CAGCCACACCTTTATTTT

2572
2589
SEQ ID
AAAATAAAGGTGTGGCTG
1.01

939
939

2567

SEQ ID
COMP ID
CCCAGCCACACCTTTATT

2574
2591
SEQ ID
AATAAAGGTGTGGCTGGG
no data

940
940

2568

SEQ ID
COMP ID
CACCCAGCCACACCTTTA

2576
2593
SEQ ID
TAAAGGTGTGGCTGGGTG
0.97

941
941

2569

SEQ ID
COMP ID
CACACCCAGCCACACCTT

2578
2595
SEQ ID
AAGGTGTGGCTGGGTGTG
0.97

942
942

2570

SEQ ID
COMP ID
ACCACACCCAGCCACACC

2580
2597
SEQ ID
GGTGTGGCTGGGTGTGGT
0.95

943
943

2571

SEQ ID
COMP ID
TCACCCCCTTTTTTTTTT

2850
2867
SEQ ID
AAAAAAAAAAGGGGGTGA
1.24

944
944

2572

SEQ ID
COMP ID
GCTCACCCCCTTTTTTTT

2852
2869
SEQ ID
AAAAAAAAGGGGGTGAGC
1.06

945
945

2573

SEQ ID
COMP ID
CTGCTCACCCCCTTTTTT

2854
2871
SEQ ID
AAAAAAGGGGGTGAGCAG
1.05

946
946

2574

SEQ ID
COMP ID
GTCTGCTCACCCCCTTTT

2856
2873
SEQ ID
AAAAGGGGGTGAGCAGAC
1.29

947
947

2575

SEQ ID
COMP ID
ACGTCTGCTCACCCCCTT

2858
2875
SEQ ID
AAGGGGGTGAGCAGACGT
1.19

948
948

2576

SEQ ID
COMP ID
CCACGTCTGCTCACCCCC

2860
2877
SEQ ID
GGGGGTGAGCAGACGTGG
1

949
949

2577

SEQ ID
COMP ID
CACCACGTCTGCTCACCC

2862
2879
SEQ ID
GGGTGAGCAGACGTGGTG
1.09

950
950

2578

SEQ ID
COMP ID
CTTTACTTTTATTTTATT

2989
3006
SEQ ID
AATAAAATAAAAGTAAAG
1.1

951
951

2579

SEQ ID
COMP ID
ACCTTTACTTTTATTTTA

2991
3008
SEQ ID
TAAAATAAAAGTAAAGGT
1.49

952
952

2580

SEQ ID
COMP ID
ATACCTTTACTTTTATTT

2993
3010
SEQ ID
AAATAAAAGTAAAGGTAT
1.29

953
953

2581

SEQ ID
COMP ID
TAATACCTTTACTTTTAT

2995
3012
SEQ ID
ATAAAAGTAAAGGTATTA
1.27

954
954

2582

SEQ ID
COMP ID
AAACAGTAATGTCTGTTG

3090
3107
SEQ ID
CAACAGACATTACTGTTT
1.38

955
955

2583

SEQ ID
COMP ID
AAAAACAGTAATGTCTGT

3092
3109
SEQ ID
ACAGACATTACTGTTTTT
1.36

956
956

2584

SEQ ID
COMP ID
GCAAAAACAGTAATGTCT

3094
3111
SEQ ID
AGACATTACTGTTTTTGC
1.23

957
957

2585

SEQ ID
COMP ID
AAGCAAAAACAGTAATGT

3096
3113
SEQ ID
ACATTACTGTTTTTGCTT
1.25

958
958

2586

SEQ ID
COMP ID
TTAAGCCCACGCCACCCT

4023
4040
SEQ ID
AGGGTGGCGTGGGCTTAA
0.78

959
959

2587

SEQ ID
COMP ID
GCTTAAGCCCACGCCACC

4025
4042
SEQ ID
GGTGGCGTGGGCTTAAGC
1.18

960
960

2588

SEQ ID
COMP ID
CTGCTTAAGCCCACGCCA

4027
4044
SEQ ID
TGGCGTGGGCTTAAGCAG
1.25

961
961

2589

SEQ ID
COMP ID
AACTGCTTAAGCCCACGC

4029
4046
SEQ ID
GCGTGGGCTTAAGCAGTT
1.32

962
962

2590

SEQ ID
COMP ID
GCAACTGCTTAAGCCCAC

4031
4048
SEQ ID
GTGGGCTTAAGCAGTTGC
1.31

963
963

2591

SEQ ID
COMP ID
TGGCAACTGCTTAAGCCC

4033
4050
SEQ ID
GGGCTTAAGCAGTTGCCA
1.06

964
964

2592

SEQ ID
COMP ID
TCTGGCAACTGCTTAAGC

4035
4052
SEQ ID
GCTTAAGCAGTTGCCAGA
1.28

965
965

2593

SEQ ID
COMP ID
CGTCTGGCAACTGCTTAA

4037
4054
SEQ ID
TTAAGCAGTTGCCAGACG
1.02

966
966

2594

SEQ ID
COMP ID
AACGTCTGGCAACTGCTT

4039
4056
SEQ ID
AAGCAGTTGCCAGACGTT
1.78

967
967

2595

SEQ ID
COMP ID
GGAACGTCTGGCAACTGC

4041
4058
SEQ ID
GCAGTTGCCAGACGTTCC
1.32

968
968

2596

SEQ ID
COMP ID
AAGGAACGTCTGGCAACT

4043
4060
SEQ ID
AGTTGCCAGACGTTCCTT
1.17

969
969

2597

SEQ ID
COMP ID
CCAAGGAACGTCTGGCAA

4045
4062
SEQ ID
TTGCCAGACGTTCCTTGG
1.29

970
970

2598

SEQ ID
COMP ID
TACCAAGGAACGTCTGGC

4047
4064
SEQ ID
GCCAGACGTTCCTTGGTA
1.34

971
971

2599

SEQ ID
COMP ID
AGTACCAAGGAACGTCTG

4049
4066
SEQ ID
CAGACGTTCCTTGGTACT
no data

972
972

2600

SEQ ID
COMP ID
AAAGTACCAAGGAACGTC

4051
4068
SEQ ID
GACGTTCCTTGGTACTTT
1.1

973
973

2601

SEQ ID
COMP ID
GCAAAGTACCAAGGAACG

4053
4070
SEQ ID
CGTTCCTTGGTACTTTGC
1.05

974
974

2602

SEQ ID
COMP ID
CTGCAAAGTACCAAGGAA

4055
4072
SEQ ID
TTCCTTGGTACTTTGCAG
1.11

975
975

2603

SEQ ID
COMP ID
AGCTCACCAGGGTCCACA
258
275
4081
4098
SEQ ID
TGTGGACCCTGGTGAGCT
1.11

976
976

2604

SEQ ID
COMP ID
CCAGCTCACCAGGGTCCA
260
277
4083
4100
SEQ ID
TGGACCCTGGTGAGCTGG
0.95

977
977

2605

SEQ ID
COMP ID
ACCCAGCTCACCAGGGTC
262
279
4085
4102
SEQ ID
GACCCTGGTGAGCTGGGT
1.1

978
978

2606

SEQ ID
COMP ID
CCACCCAGCTCACCAGGG
264
281
4087
4104
SEQ ID
CCCTGGTGAGCTGGGTGG
0.98

979
979

2607

SEQ ID
COMP ID
GGCCACCCAGCTCACCAG
266
283
4089
4106
SEQ ID
CTGGTGAGCTGGGTGGCC
no data

980
980

2608

SEQ ID
COMP ID
AAGGCCACCCAGCTCACC
268
285
4091
4108
SEQ ID
GGTGAGCTGGGTGGCCTT
0.98

981
981

2609

SEQ ID
COMP ID
TTAAGGCCACCCAGCTCA
270
287
4093
4110
SEQ ID
TGAGCTGGGTGGCCTTAA
1.11

982
982

2610

SEQ ID
COMP ID
TGTTAAGGCCACCCAGCT
272
289
4095
4112
SEQ ID
AGCTGGGTGGCCTTAACA
no data

983
983

2611

SEQ ID
COMP ID
GCTGTTAAGGCCACCCAG
274
291
4097
4114
SEQ ID
CTGGGTGGCCTTAACAGC
no data

984
984

2612

SEQ ID
COMP ID
CTGCTGTTAAGGCCACCC
276
293
4099
4116
SEQ ID
GGGTGGCCTTAACAGCAG
1.37

985
985

2613

SEQ ID
COMP ID
CCCTGCTGTTAAGGCCAC
278
295
4101
4118
SEQ ID
GTGGCCTTAACAGCAGGG
1.15

986
986

2614

SEQ ID
COMP ID
AGCCCTGCTGTTAAGGCC
280
297
4103
4120
SEQ ID
GGCCTTAACAGCAGGGCT
1.32

987
987

2615

SEQ ID
COMP ID
CCAGCCCTGCTGTTAAGG
282
299
4105
4122
SEQ ID
CCTTAACAGCAGGGCTGG
no data

988
988

2616

SEQ ID
COMP ID
CACCAGCCCTGCTGTTAA
284
301
4107
4124
SEQ ID
TTAACAGCAGGGCTGGTG
no data

989
989

2617

SEQ ID
COMP ID
GCCACCAGCCCTGCTGTT
286
303
4109
4126
SEQ ID
AACAGCAGGGCTGGTGGC
no data

990
990

2618

SEQ ID
COMP ID
CAGCCACCAGCCCTGCTG
288
305
4111
4128
SEQ ID
CAGCAGGGCTGGTGGCTG
1.03

991
991

2619

SEQ ID
COMP ID
TCCAGCCACCAGCCCTGC
290
307
4113
4130
SEQ ID
GCAGGGCTGGTGGCTGGA
no data

992
992

2620

SEQ ID
COMP ID
GTTCCAGCCACCAGCCCT
292
309
4115
4132
SEQ ID
AGGGCTGGTGGCTGGAAC
no data

993
993

2621

SEQ ID
COMP ID
GCGTTCCAGCCACCAGCC
294
311
4117
4134
SEQ ID
GGCTGGTGGCTGGAACGC
1.08

994
994

2622

SEQ ID
COMP ID
CCGCGTTCCAGCCACCAG
296
313
4119
4136
SEQ ID
CTGGTGGCTGGAACGCGG
1.3

995
995

2623

SEQ ID
COMP ID
CACCGCGTTCCAGCCACC
298
315
4121
4138
SEQ ID
GGTGGCTGGAACGCGGTG
1.1

996
996

2624

SEQ ID
COMP ID
GGCACCGCGTTCCAGCCA
300
317
4123
4140
SEQ ID
TGGCTGGAACGCGGTGCC
1.37

997
997

2625

SEQ ID
COMP ID
TGGGCACCGCGTTCCAGC
302
319
4125
4142
SEQ ID
GCTGGAACGCGGTGCCCA
2.02

998
998

2626

SEQ ID
COMP ID
TCTGGGCACCGCGTTCCA
304
321
4127
4144
SEQ ID
TGGAACGCGGTGCCCAGA
1.39

999
999

2627

SEQ ID
COMP ID
CATCTGGGCACCGCGTTC
306
323
4129
4146
SEQ ID
GAACGCGGTGCCCAGATG
3.11

1000
1000

2628

SEQ ID
COMP ID
ACCATCTGGGCACCGCGT
308
325
4131
4148
SEQ ID
ACGCGGTGCCCAGATGGT
1.72

1001
1001

2629

SEQ ID
COMP ID
TGACCATCTGGGCACCGC
310
327
4133
4150
SEQ ID
GCGGTGCCCAGATGGTCA
1.59

1002
1002

2630

SEQ ID
COMP ID
ACTGACCATCTGGGCACC
312
329
4135
4152
SEQ ID
GGTGCCCAGATGGTCAGT
2.08

1003
1003

2631

SEQ ID
COMP ID
GAACTGACCATCTGGGCA
314
331
4137
4154
SEQ ID
TGCCCAGATGGTCAGTTC
1.41

1004
1004

2632

SEQ ID
COMP ID
CAGAACTGACCATCTGGG
316
333
4139
4156
SEQ ID
CCCAGATGGTCAGTTCTG
1.56

1005
1005

2633

SEQ ID
COMP ID
GGCAGAACTGACCATCTG
318
335
4141
4158
SEQ ID
CAGATGGTCAGTTCTGCC
1.44

1006
1006

2634

SEQ ID
COMP ID
AGGGCAGAACTGACCATC
320
337
4143
4160
SEQ ID
GATGGTCAGTTCTGCCCT
1.27

1007
1007

2635

SEQ ID
COMP ID
ACAGGGCAGAACTGACCA
322
339
4145
4162
SEQ ID
TGGTCAGTTCTGCCCTGT
1.42

1008
1008

2636

SEQ ID
COMP ID
CCACAGGGCAGAACTGAC
324
341
4147
4164
SEQ ID
GTCAGTTCTGCCCTGTGG
1.19

1009
1009

2637

SEQ ID
COMP ID
GGCCACAGGGCAGAACTG
326
343
4149
4166
SEQ ID
CAGTTCTGCCCTGTGGCC
1.68

1010
1010

2638

SEQ ID
COMP ID
CAGGCCACAGGGCAGAAC
328
345
4151
4168
SEQ ID
GTTCTGCCCTGTGGCCTG
3.42

1011
1011

2639

SEQ ID
COMP ID
AGCAGGCCACAGGGCAGA
330
347
4153
4170
SEQ ID
TCTGCCCTGTGGCCTGCT
2.95

1012
1012

2640

SEQ ID
COMP ID
GCAGCAGGCCACAGGGCA
332
349
4155
4172
SEQ ID
TGCCCTGTGGCCTGCTGC
1.37

1013
1013

2641

SEQ ID
COMP ID
AGGCAGCAGGCCACAGGG
334
351
4157
4174
SEQ ID
CCCTGTGGCCTGCTGCCT
1.46

1014
1014

2642

SEQ ID
COMP ID
CCAGGCAGCAGGCCACAG
336
353
4159
4176
SEQ ID
CTGTGGCCTGCTGCCTGG
1.34

1015
1015

2643

SEQ ID
COMP ID
GTCCAGGCAGCAGGCCAC
338
355
4161
4178
SEQ ID
GTGGCCTGCTGCCTGGAC
1.49

1016
1016

2644

SEQ ID
COMP ID
GGGTCCAGGCAGCAGGCC
340
357
4163
4180
SEQ ID
GGCCTGCTGCCTGGACCC
1.45

1017
1017

2645

SEQ ID
COMP ID
CGGGGTCCAGGCAGCAGG
342
359
4165
4182
SEQ ID
CCTGCTGCCTGGACCCCG
1.31

1018
1018

2646

SEQ ID
COMP ID
TCCGGGGTCCAGGCAGCA
344
361
4167
4184
SEQ ID
TGCTGCCTGGACCCCGGA
1.37

1019
1019

2647

SEQ ID
COMP ID
CCTCCGGGGTCCAGGCAG
346
363
4169
4186
SEQ ID
CTGCCTGGACCCCGGAGG
1.27

1020
1020

2648

SEQ ID
COMP ID
CTCCTCCGGGGTCCAGGC
348
365
4171
4188
SEQ ID
GCCTGGACCCCGGAGGAG
1.5

1021
1021

2649

SEQ ID
COMP ID
GGCTCCTCCGGGGTCCAG
350
367
4173
4190
SEQ ID
CTGGACCCCGGAGGAGCC
1.12

1022
1022

2650

SEQ ID
COMP ID
CTGGCTCCTCCGGGGTCC
352
369
4175
4192
SEQ ID
GGACCCCGGAGGAGCCAG
1.99

1023
1023

2651

SEQ ID
COMP ID
AGCTGGCTCCTCCGGGGT
354
371
4177
4194
SEQ ID
ACCCCGGAGGAGCCAGCT
3.06

1024
1024

2652

SEQ ID
COMP ID
GTAGCTGGCTCCTCCGGG
356
373
4179
4196
SEQ ID
CCCGGAGGAGCCAGCTAC
1.47

1025
1025

2653

SEQ ID
COMP ID
CTGTAGCTGGCTCCTCCG
358
375
4181
4198
SEQ ID
CGGAGGAGCCAGCTACAG
1.28

1026
1026

2654

SEQ ID
COMP ID
AGCTGTAGCTGGCTCCTC
360
377
4183
4200
SEQ ID
GAGGAGCCAGCTACAGCT
1.51

1027
1027

2655

SEQ ID
COMP ID
GCAGCTGTAGCTGGCTCC
362
379
4185
4202
SEQ ID
GGAGCCAGCTACAGCTGC
1.39

1028
1028

2656

SEQ ID
COMP ID
CAGCAGCTGTAGCTGGCT
364
381
4187
4204
SEQ ID
AGCCAGCTACAGCTGCTG
no data

1029
1029

2657

SEQ ID
COMP ID
GGCAGCAGCTGTAGCTGG
366
383
4189
4206
SEQ ID
CCAGCTACAGCTGCTGCC
2.41

1030
1030

2658

SEQ ID
COMP ID
ACGGCAGCAGCTGTAGCT
368
385
4191
4208
SEQ ID
AGCTACAGCTGCTGCCGT
1.28

1031
1031

2659

SEQ ID
COMP ID
GGACGGCAGCAGCTGTAG
370
387
4193
4210
SEQ ID
CTACAGCTGCTGCCGTCC
1.38

1032
1032

2660

SEQ ID
COMP ID
GGGGACGGCAGCAGCTGT
372
389
4195
4212
SEQ ID
ACAGCTGCTGCCGTCCCC
1.3

1033
1033

2661

SEQ ID
COMP ID
AAGGGGACGGCAGCAGCT
374
391
4197
4214
SEQ ID
AGCTGCTGCCGTCCCCTT
1.09

1034
1034

2662

SEQ ID
COMP ID
AGAAGGGGACGGCAGCAG
376
393
4199
4216
SEQ ID
CTGCTGCCGTCCCCTTCT
1.46

1035
1035

2663

SEQ ID
COMP ID
CCAGAAGGGGACGGCAGC
378
395
4201
4218
SEQ ID
GCTGCCGTCCCCTTCTGG
1.43

1036
1036

2664

SEQ ID
COMP ID
CACCAGAAGGGGACGGCA

4203
4220
SEQ ID
TGCCGTCCCCTTCTGGTG
2.14

1037
1037

2665

SEQ ID
COMP ID
CTCACCAGAAGGGGACGG

4205
4222
SEQ ID
CCGTCCCCTTCTGGTGAG
1.57

1038
1038

2666

SEQ ID
COMP ID
CACTCACCAGAAGGGGAC

4207
4224
SEQ ID
GTCCCCTTCTGGTGAGTG
1.99

1039
1039

2667

SEQ ID
COMP ID
GGCACTCACCAGAAGGGG

4209
4226
SEQ ID
CCCCTTCTGGTGAGTGCC
1.3

1040
1040

2668

SEQ ID
COMP ID
GGGGCACTCACCAGAAGG

4211
4228
SEQ ID
CCTTCTGGTGAGTGCCCC
1.55

1041
1041

2669

SEQ ID
COMP ID
GAGGGGCACTCACCAGAA

4213
4230
SEQ ID
TTCTGGTGAGTGCCCCTC
1.6

1042
1042

2670

SEQ ID
COMP ID
CTGAGGGGCACTCACCAG

4215
4232
SEQ ID
CTGGTGAGTGCCCCTCAG
1.45

1043
1043

2671

SEQ ID
COMP ID
GGCTGAGGGGCACTCACC

4217
4234
SEQ ID
GGTGAGTGCCCCTCAGCC
1.36

1044
1044

2672

SEQ ID
COMP ID
TAGGCTGAGGGGCACTCA

4219
4236
SEQ ID
TGAGTGCCCCTCAGCCTA
1.04

1045
1045

2673

SEQ ID
COMP ID
CCTAGGCTGAGGGGCACT

4221
4238
SEQ ID
AGTGCCCCTCAGCCTAGG
1.28

1046
1046

2674

SEQ ID
COMP ID
TGCCTAGGCTGAGGGGCA

4223
4240
SEQ ID
TGCCCCTCAGCCTAGGCA
1.04

1047
1047

2675

SEQ ID
COMP ID
CTTGCCTAGGCTGAGGGG

4225
4242
SEQ ID
CCCCTCAGCCTAGGCAAG
2.21

1048
1048

2676

SEQ ID
COMP ID
CTCTTGCCTAGGCTGAGG

4227
4244
SEQ ID
CCTCAGCCTAGGCAAGAG
2.23

1049
1049

2677

SEQ ID
COMP ID
AGCTCTTGCCTAGGCTGA

4229
4246
SEQ ID
TCAGCCTAGGCAAGAGCT
1.6

1050
1050

2678

SEQ ID
COMP ID
CCAGCTCTTGCCTAGGCT

4231
4248
SEQ ID
AGCCTAGGCAAGAGCTGG
2.54

1051
1051

2679

SEQ ID
COMP ID
TGCCAGCTCTTGCCTAGG

4233
4250
SEQ ID
CCTAGGCAAGAGCTGGCA
1.49

1052
1052

2680

SEQ ID
COMP ID
GCTGCCAGCTCTTGCCTA

4235
4252
SEQ ID
TAGGCAAGAGCTGGCAGC
.33

1053
1053

2681

SEQ ID
COMP ID
AGGCTGCCAGCTCTTGCC

4237
4254
SEQ ID
GGCAAGAGCTGGCAGCCT
2.65

1054
1054

2682

SEQ ID
COMP ID
CCAGGCTGCCAGCTCTTG

4239
4256
SEQ ID
CAAGAGCTGGCAGCCTGG
1.35

1055
1055

2683

SEQ ID
COMP ID
ACCCAGGCTGCCAGCTCT

4241
4258
SEQ ID
AGAGCTGGCAGCCTGGGT
1.36

1056
1056

2684

SEQ ID
COMP ID
AAACCCAGGCTGCCAGCT

4243
4260
SEQ ID
AGCTGGCAGCCTGGGTTT
1.39

1057
1057

2685

SEQ ID
COMP ID
GAAAACCCAGGCTGCCAG

4245
4262
SEQ ID
CTGGCAGCCTGGGTTTTC
1.98

1058
1058

2686

SEQ ID
COMP ID
GGGAAAACCCAGGCTGCC

4247
4264
SEQ ID
GGCAGCCTGGGTTTTCCC
1.33

1059
1059

2687

SEQ ID
COMP ID
TTGGGAAAACCCAGGCTG

4249
4266
SEQ ID
CAGCCTGGGTTTTCCCAA
1.98

1060
1060

2688

SEQ ID
COMP ID
CTTTGGGAAAACCCAGGC

4251
4268
SEQ ID
GCCTGGGTTTTCCCAAAG
2.94

1061
1061

2689

SEQ ID
COMP ID
CTTGTGCCTGGCGTCCTC

4291
4308
SEQ ID
GAGGACGCCAGGCACAAG
1.49

1062
1062

2690

SEQ ID
COMP ID
GACTTGTGCCTGGCGTCC

4293
4310
SEQ ID
GGACGCCAGGCACAAGTC
2.06

1063
1063

2691

SEQ ID
COMP ID
CAGACTTGTGCCTGGCGT

4295
4312
SEQ ID
ACGCCAGGCACAAGTCTG
0.96

1064
1064

2692

SEQ ID
COMP ID
CACAGACTTGTGCCTGGC

4297
4314
SEQ ID
GCCAGGCACAAGTCTGTG
1.39

1065
1065

2693

SEQ ID
COMP ID
ACCACAGACTTGTGCCTG

4299
4316
SEQ ID
CAGGCACAAGTCTGTGGT
3.05

1066
1066

2694

SEQ ID
COMP ID
AAACCACAGACTTGTGCC

4301
4318
SEQ ID
GGCACAAGTCTGTGGTTT
1.3

1067
1067

2695

SEQ ID
COMP ID
ATAAACCACAGACTTGTG

4303
4320
SEQ ID
CACAAGTCTGTGGTTTAT
1.03

1068
1068

2696

SEQ ID
COMP ID
TGATAAACCACAGACTTG

4305
4322
SEQ ID
CAAGTCTGTGGTTTATCA
1.45

1069
1069

2697

SEQ ID
COMP ID
AATGATAAACCACAGACT

4307
4324
SEQ ID
AGTCTGTGGTTTATCATT
1.7

1070
1070

2698

SEQ ID
COMP ID
AAAATGATAAACCACAGA

4309
4326
SEQ ID
TCTGTGGTTTATCATTTT
3.49

1071
1071

2699

SEQ ID
COMP ID
GGAAAATGATAAACCACA

4311
4328
SEQ ID
TGTGGTTTATCATTTTCC
4

1072
1072

2700

SEQ ID
COMP ID
AGGGAAAATGATAAACCA

4313
4330
SEQ ID
TGGTTTATCATTTTCCCT
1.86

1073
1073

2701

SEQ ID
COMP ID
ACAGGGAAAATGATAAAC

4315
4332
SEQ ID
GTTTATCATTTTCCCTGT
1.21

1074
1074

2702

SEQ ID
COMP ID
AGACAGGGAAAATGATAA

4317
4334
SEQ ID
TTATCATTTTCCCTGTCT
1.56

1075
1075

2703

SEQ ID
COMP ID
AAAGACAGGGAAAATGAT

4319
4336
SEQ ID
ATCATTTTCCCTGTCTTT
1.42

1076
1076

2704

SEQ ID
COMP ID
AGAAAGACAGGGAAAATG

4321
4338
SEQ ID
CATTTTCCCTGTCTTTCT
1.43

1077
1077

2705

SEQ ID
COMP ID
CTAGAAAGACAGGGAAAA

4323
4340
SEQ ID
TTTTCCCTGTCTTTCTAG
2.88

1078
1078

2706

SEQ ID
COMP ID
TCCTAGAAAGACAGGGAA

4325
4342
SEQ ID
TTCCCTGTCTTTCTAGGA
1.09

1079
1079

2707

SEQ ID
COMP ID
TGTCCTAGAAAGACAGGG

4327
4344
SEQ ID
CCCTGTCTTTCTAGGACA
1.31

1080
1080

2708

SEQ ID
COMP ID
TTTGTCCTAGAAAGACAG

4329
4346
SEQ ID
CTGTCTTTCTAGGACAAA
1.75

1081
1081

2709

SEQ ID
COMP ID
CATTTGTCCTAGAAAGAC

4331
4348
SEQ ID
GTCTTTCTAGGACAAATG
1.43

1082
1082

2710

SEQ ID
COMP ID
GCCATTTGTCCTAGAAAG

4333
4350
SEQ ID
CTTTCTAGGACAAATGGC
2.88

1083
1083

2711

SEQ ID
COMP ID
GGGCCATTTGTCCTAGAA

4335
4352
SEQ ID
TTCTAGGACAAATGGCCC
1.65

1084
1084

2712

SEQ ID
COMP ID
GTGGGCCATTTGTCCTAG

4337
4354
SEQ ID
CTAGGACAAATGGCCCAC
1.73

1085
1085

2713

SEQ ID
COMP ID
TTGTGGGCCATTTGTCCT

4339
4356
SEQ ID
AGGACAAATGGCCCACAA
.52

1086
1086

2714

SEQ ID
COMP ID
TGTTGTGGGCCATTTGTC
395
412
4341
4358
SEQ ID
GACAAATGGCCCACAACA
1.27

1087
1087

2715

SEQ ID
COMP ID
AGTGTTGTGGGCCATTTG
397
414
4343
4360
SEQ ID
CAAATGGCCCACAACACT
1.35

1088
1088

2716

SEQ ID
COMP ID
TCAGTGTTGTGGGCCATT
399
416
4345
4362
SEQ ID
AATGGCCCACAACACTGA
1.46

1089
1089

2717

SEQ ID
COMP ID
GCTCAGTGTTGTGGGCCA
401
418
4347
4364
SEQ ID
TGGCCCACAACACTGAGC
1.49

1090
1090

2718

SEQ ID
COMP ID
CTGCTCAGTGTTGTGGGC
403
420
4349
4366
SEQ ID
GCCCACAACACTGAGCAG
1.51

1091
1091

2719

SEQ ID
COMP ID
GCCTGCTCAGTGTTGTGG
405
422
4351
4368
SEQ ID
CCACAACACTGAGCAGGC
1.5

1092
1092

2720

SEQ ID
COMP ID
ATGCCTGCTCAGTGTTGT
407
424
4353
4370
SEQ ID
ACAACACTGAGCAGGCAT
1.56

1093
1093

2721

SEQ ID
COMP ID
AGATGCCTGCTCAGTGTT
409
426
4355
4372
SEQ ID
AACACTGAGCAGGCATCT
1.43

1094
1094

2722

SEQ ID
COMP ID
CCAGATGCCTGCTCAGTG
411
428
4357
4374
SEQ ID
CACTGAGCAGGCATCTGG
1.21

1095
1095

2723

SEQ ID
COMP ID
ACCCAGATGCCTGCTCAG
413
430
4359
4376
SEQ ID
CTGAGCAGGCATCTGGGT
0.95

1096
1096

2724

SEQ ID
COMP ID
CCACCCAGATGCCTGCTC
415
432
4361
4378
SEQ ID
GAGCAGGCATCTGGGTGG
0.95

1097
1097

2725

SEQ ID
COMP ID
GGCCACCCAGATGCCTGC
417
434
4363
4380
SEQ ID
GCAGGCATCTGGGTGGCC
1.25

1098
1098

2726

SEQ ID
COMP ID
GGGGCCACCCAGATGCCT
419
436
4365
4382
SEQ ID
AGGCATCTGGGTGGCCCC
1.44

1099
1099

2727

SEQ ID
COMP ID
CAGGGGCCACCCAGATGC
421
438
4367
4384
SEQ ID
GCATCTGGGTGGCCCCTG
1.44

1100
1100

2728

SEQ ID
COMP ID
GGCAGGGGCCACCCAGAT
423
440
4369
4386
SEQ ID
ATCTGGGTGGCCCCTGCC
1.05

1101
1101

2729

SEQ ID
COMP ID
CTGGCAGGGGCCACCCAG
425
442
4371
4388
SEQ ID
CTGGGTGGCCCCTGCCAG
1.19

1102
1102

2730

SEQ ID
COMP ID
ACCTGGCAGGGGCCACCC
427
444
4373
4390
SEQ ID
GGGTGGCCCCTGCCAGGT
0.94

1103
1103

2731

SEQ ID
COMP ID
CAACCTGGCAGGGGCCAC
429
446
4375
4392
SEQ ID
GTGGCCCCTGCCAGGTTG
0.89

1104
1104

2732

SEQ ID
COMP ID
ATCAACCTGGCAGGGGCC
431
448
4377
4394
SEQ ID
GGCCCCTGCCAGGTTGAT
1.01

1105
1105

2733

SEQ ID
COMP ID
GCATCAACCTGGCAGGGG
433
450
4379
4396
SEQ ID
CCCCTGCCAGGTTGATGC
1.46

1106
1106

2734

SEQ ID
COMP ID
GGGCATCAACCTGGCAGG
435
452
4381
4398
SEQ ID
CCTGCCAGGTTGATGCCC
1.04

1107
1107

2735

SEQ ID
COMP ID
GTGGGCATCAACCTGGCA
437
454
4383
4400
SEQ ID
TGCCAGGTTGATGCCCAC
1.21

1108
1108

2736

SEQ ID
COMP ID
CAGTGGGCATCAACCTGG
439
456
4385
4402
SEQ ID
CCAGGTTGATGCCCACTG
1.61

1109
1109

2737

SEQ ID
COMP ID
AGCAGTGGGCATCAACCT
441
458
4387
4404
SEQ ID
AGGTTGATGCCCACTGCT
1.46

1110
1110

2738

SEQ ID
COMP ID
AGAGCAGTGGGCATCAAC
443
460
4389
4406
SEQ ID
GTTGATGCCCACTGCTCT
1.91

1111
1111

2739

SEQ ID
COMP ID
GCAGAGCAGTGGGCATCA
445
462
4391
4408
SEQ ID
TGATGCCCACTGCTCTGC
1.64

1112
1112

2740

SEQ ID
COMP ID
CGGCAGAGCAGTGGGCAT
447
464
4393
4410
SEQ ID
ATGCCCACTGCTCTGCCG
1.71

1113
1113

2741

SEQ ID
COMP ID
GCCGGCAGAGCAGTGGGC
449
466
4395
4412
SEQ ID
GCCCACTGCTCTGCCGGC
1.56

1114
1114

2742

SEQ ID
COMP ID
TGGCCGGCAGAGCAGTGG
451
468
4397
4414
SEQ ID
CCACTGCTCTGCCGGCCA
2.52

1115
1115

2743

SEQ ID
COMP ID
AGTGGCCGGCAGAGCAGT
453
470
4399
4416
SEQ ID
ACTGCTCTGCCGGCCACT
2.42

1116
1116

2744

SEQ ID
COMP ID
GGAGTGGCCGGCAGAGCA
455
472
4401
4418
SEQ ID
TGCTCTGCCGGCCACTCC
2.76

1117
1117

2745

SEQ ID
COMP ID
CAGGAGTGGCCGGCAGAG
457
474
4403
4420
SEQ ID
CTCTGCCGGCCACTCCTG
2.72

1118
1118

2746

SEQ ID
COMP ID
TGCAGGAGTGGCCGGCAG
459
476
4405
4422
SEQ ID
CTGCCGGCCACTCCTGCA
2.53

1119
1119

2747

SEQ ID
COMP ID
GATGCAGGAGTGGCCGGC
461
478
4407
4424
SEQ ID
GCCGGCCACTCCTGCATC
3.01

1120
1120

2748

SEQ ID
COMP ID
AAGATGCAGGAGTGGCCG
463
480
4409
4426
SEQ ID
CGGCCACTCCTGCATCTT
2.48

1121
1121

2749

SEQ ID
COMP ID
TAAAGATGCAGGAGTGGC
465
482
4411
4428
SEQ ID
GCCACTCCTGCATCTTTA
2.48

1122
1122

2750

SEQ ID
COMP ID
GGTAAAGATGCAGGAGTG
467
484
4413
4430
SEQ ID
CACTCCTGCATCTTTACC
1.85

1123
1123

2751

SEQ ID
COMP ID
ACGGTAAAGATGCAGGAG
469
486
4415
4432
SEQ ID
CTCCTGCATCTTTACCGT
1.92

1124
1124

2752

SEQ ID
COMP ID
AGACGGTAAAGATGCAGG
471
488
4417
4434
SEQ ID
CCTGCATCTTTACCGTCT
1.59

1125
1125

2753

SEQ ID
COMP ID
TGAGACGGTAAAGATGCA
473
490
4419
4436
SEQ ID
TGCATCTTTACCGTCTCA
1.73

1126
1126

2754

SEQ ID
COMP ID
CCTGAGACGGTAAAGATG
475
492
4421
4438
SEQ ID
CATCTTTACCGTCTCAGG
1.82

1127
1127

2755

SEQ ID
COMP ID
TCCCTGAGACGGTAAAGA
477
494
4423
4440
SEQ ID
TCTTTACCGTCTCAGGGA
1.56

1128
1128

2756

SEQ ID
COMP ID
AGTCCCTGAGACGGTAAA
479
496
4425
4442
SEQ ID
TTTACCGTCTCAGGGACT
1.56

1129
1129

2757

SEQ ID
COMP ID
GAAGTCCCTGAGACGGTA
481
498
4427
4444
SEQ ID
TACCGTCTCAGGGACTTC
1.64

1130
1130

2758

SEQ ID
COMP ID
TGGAAGTCCCTGAGACGG
483
500
4429
4446
SEQ ID
CCGTCTCAGGGACTTCCA
1.43

1131
1131

2759

SEQ ID
COMP ID
ACTGGAAGTCCCTGAGAC
485
502
4431
4448
SEQ ID
GTCTCAGGGACTTCCAGT
1.51

1132
1132

2760

SEQ ID
COMP ID
CAACTGGAAGTCCCTGAG
487
504
4433
4450
SEQ ID
CTCAGGGACTTCCAGTTG
1.35

1133
1133

2761

SEQ ID
COMP ID
AGCAACTGGAAGTCCCTG
489
506
4435
4452
SEQ ID
CAGGGACTTCCAGTTGCT
1.29

1134
1134

2762

SEQ ID
COMP ID
GCAGCAACTGGAAGTCCC
491
508
4437
4454
SEQ ID
GGGACTTCCAGTTGCTGC
1.64

1135
1135

2763

SEQ ID
COMP ID
GGGCAGCAACTGGAAGTC
493
510
4439
4456
SEQ ID
GACTTCCAGTTGCTGCCC
3.51

1136
1136

2764

SEQ ID
COMP ID
AGGGGCAGCAACTGGAAG
495
512
4441
4458
SEQ ID
CTTCCAGTTGCTGCCCCT
2.93

1137
1137

2765

SEQ ID
COMP ID
GAAGGGGCAGCAACTGGA
497
514
4443
4460
SEQ ID
TCCAGTTGCTGCCCCTTC
3.49

1138
1138

2766

SEQ ID
COMP ID
GGGAAGGGGCAGCAACTG
499
516
4445
4462
SEQ ID
CAGTTGCTGCCCCTTCCC
3.34

1139
1139

2767

SEQ ID
COMP ID
CTGGGAAGGGGCAGCAAC
501
518
4447
4464
SEQ ID
GTTGCTGCCCCTTCCCAG
3.12

1140
1140

2768

SEQ ID
COMP ID
CTCTGGGAAGGGGCAGCA
503
520
4449
4466
SEQ ID
TGCTGCCCCTTCCCAGAG
2.58

1141
1141

2769

SEQ ID
COMP ID
ACCTCTGGGAAGGGGCAG

4451
4468
SEQ ID
CTGCCCCTTCCCAGAGGT
3.04

1142
1142

2770

SEQ ID
COMP ID
TCACCTCTGGGAAGGGGC

4453
4470
SEQ ID
GCCCCTTCCCAGAGGTGA
2.53

1143
1143

2771

SEQ ID
COMP ID
GCTCACCTCTGGGAAGGG

4455
4472
SEQ ID
CCCTTCCCAGAGGTGAGC
1.9

1144
1144

2772

SEQ ID
COMP ID
ACGCTCACCTCTGGGAAG

4457
4474
SEQ ID
CTTCCCAGAGGTGAGCGT
1.37

1145
1145

2773

SEQ ID
COMP ID
GCACGCTCACCTCTGGGA

4459
4476
SEQ ID
TCCCAGAGGTGAGCGTGC
1.82

1146
1146

2774

SEQ ID
COMP ID
TGGCACGCTCACCTCTGG

4461
4478
SEQ ID
CCAGAGGTGAGCGTGCCA
1.43

1147
1147

2775

SEQ ID
COMP ID
GATGGCACGCTCACCTCT

4463
4480
SEQ ID
AGAGGTGAGCGTGCCATC
no data

1148
1148

2776

SEQ ID
COMP ID
CTGATGGCACGCTCACCT

4465
4482
SEQ ID
AGGTGAGCGTGCCATCAG
no data

1149
1149

2777

SEQ ID
COMP ID
GGCTGATGGCACGCTCAC

4467
4484
SEQ ID
GTGAGCGTGCCATCAGCC
no data

1150
1150

2778

SEQ ID
COMP ID
TGGGCTGATGGCACGCTC

4469
4486
SEQ ID
GAGCGTGCCATCAGCCCA
no data

1151
1151

2779

SEQ ID
COMP ID
ACTGGGCTGATGGCACGC

4471
4488
SEQ ID
GCGTGCCATCAGCCCAGT
no data

1152
1152

2780

SEQ ID
COMP ID
CCACTGGGCTGATGGCAC

4473
4490
SEQ ID
GTGCCATCAGCCCAGTGG
no data

1153
1153

2781

SEQ ID
COMP ID
CTCCACTGGGCTGATGGC

4475
4492
SEQ ID
GCCATCAGCCCAGTGGAG
no data

1154
1154

2782

SEQ ID
COMP ID
CCCTCCACTGGGCTGATG

4477
4494
SEQ ID
CATCAGCCCAGTGGAGGG
no data

1155
1155

2783

SEQ ID
COMP ID
GCCCCTCCACTGGGCTGA

4479
4496
SEQ ID
TCAGCCCAGTGGAGGGGC
no data

1156
1156

2784

SEQ ID
COMP ID
AAGCCCCTCCACTGGGCT

4481
4498
SEQ ID
AGCCCAGTGGAGGGGCTT
no data

1157
1157

2785

SEQ ID
COMP ID
CTAAGCCCCTCCACTGGG

4483
4500
SEQ ID
CCCAGTGGAGGGGCTTAG
no data

1158
1158

2786

SEQ ID
COMP ID
ACCTAAGCCCCTCCACTG

4485
4502
SEQ ID
CAGTGGAGGGGCTTAGGT
no data

1159
1159

2787

SEQ ID
COMP ID
AGACCTAAGCCCCTCCAC

4487
4504
SEQ ID
GTGGAGGGGCTTAGGTCT
no data

1160
1160

2788

SEQ ID
COMP ID
GCAGACCTAAGCCCCTCC

4489
4506
SEQ ID
GGAGGGGCTTAGGTCTGC
no data

1161
1161

2789

SEQ ID
COMP ID
ATGCAGACCTAAGCCCCT

4491
4508
SEQ ID
AGGGGCTTAGGTCTGCAT
no data

1162
1162

2790

SEQ ID
COMP ID
AAATGCAGACCTAAGCCC

4493
4510
SEQ ID
GGGCTTAGGTCTGCATTT
no data

1163
1163

2791

SEQ ID
COMP ID
ATAAATGCAGACCTAAGC

4495
4512
SEQ ID
GCTTAGGTCTGCATTTAT
no data

1164
1164

2792

SEQ ID
COMP ID
GCATAAATGCAGACCTAA

4497
4514
SEQ ID
TTAGGTCTGCATTTATGC
no data

1165
1165

2793

SEQ ID
COMP ID
AAGCATAAATGCAGACCT

4499
4516
SEQ ID
AGGTCTGCATTTATGCTT
no data

1166
1166

2794

SEQ ID
COMP ID
CCCTTTTATCTGCAGGTG

4531
4548
SEQ ID
CACCTGCAGATAAAAGGG
no data

1167
1167

2795

SEQ ID
COMP ID
GGCCCTTTTATCTGCAGG

4533
4550
SEQ ID
CCTGCAGATAAAAGGGCC
no data

1168
1168

2796

SEQ ID
COMP ID
AGGGCCCTTTTATCTGCA

4535
4552
SEQ ID
TGCAGATAAAAGGGCCCT
no data

1169
1169

2797

SEQ ID
COMP ID
GCAGGGCCCTTTTATCTG

4537
4554
SEQ ID
CAGATAAAAGGGCCCTGC
no data

1170
1170

2798

SEQ ID
COMP ID
TGGCAGGGCCCTTTTATC

4539
4556
SEQ ID
GATAAAAGGGCCCTGCCA
no data

171
1171

2799

SEQ ID
COMP ID
ATTGGCAGGGCCCTTTTA

4541
4558
SEQ ID
TAAAAGGGCCCTGCCAAT
no data

1172
1172

2800

SEQ ID
COMP ID
GCATTGGCAGGGCCCTTT

4543
4560
SEQ ID
AAAGGGCCCTGCCAATGC
no data

1173
1173

2801

SEQ ID
COMP ID
CTGCATTGGCAGGGCCCT

4545
4562
SEQ ID
AGGGCCCTGCCAATGCAG
no data

1174
1174

2802

SEQ ID
COMP ID
ACCTGCATTGGCAGGGCC

4547
4564
SEQ ID
GGCCCTGCCAATGCAGGT
no data

1175
1175

2803

SEQ ID
COMP ID
AAACCTGCATTGGCAGGG

4549
4566
SEQ ID
CCCTGCCAATGCAGGTTT
no data

1176
1176

2804

SEQ ID
COMP ID
AGAAACCTGCATTGGCAG

4551
4568
SEQ ID
CTGCCAATGCAGGTTTCT
no data

1177
1177

2805

SEQ ID
COMP ID
AGAGAAACCTGCATTGGC

4553
4570
SEQ ID
GCCAATGCAGGTTTCTCT
no data

1178
1178

2806

SEQ ID
COMP ID
ACAGAGAAACCTGCATTG

4555
4572
SEQ ID
CAATGCAGGTTTCTCTGT
no data

1179
1179

2807

SEQ ID
COMP ID
ACACAGAGAAACCTGCAT

4557
4574
SEQ ID
ATGCAGGTTTCTCTGTGT
no data

1180
1180

2808

SEQ ID
COMP ID
GAACACAGAGAAACCTGC

4559
4576
SEQ ID
GCAGGTTTCTCTGTGTTC
no data

1181
1181

2809

SEQ ID
COMP ID
TGGAACACAGAGAAACCT

4561
4578
SEQ ID
AGGTTTCTCTGTGTTCCA
no data

1182
1182

2810

SEQ ID
COMP ID
TGTGGAACACAGAGAAAC

4563
4580
SEQ ID
GTTTCTCTGTGTTCCACA
no data

1183
1183

2811

SEQ ID
COMP ID
CCTGTGGAACACAGAGAA

4565
4582
SEQ ID
TTCTCTGTGTTCCACAGG
no data

1184
1184

2812

SEQ ID
COMP ID
GGCCTGTGGAACACAGAG

4567
4584
SEQ ID
CTCTGTGTTCCACAGGCC
no data

1185
1185

2813

SEQ ID
COMP ID
ACGGCCTGTGGAACACAG

4569
4586
SEQ ID
CTGTGTTCCACAGGCCGT
no data

1186
1186

2814

SEQ ID
COMP ID
CCACGGCCTGTGGAACAC

4571
4588
SEQ ID
GTGTTCCACAGGCCGTGG
1.25

1187
1187

2815

SEQ ID
COMP ID
TGCCACGGCCTGTGGAAC

4573
4590
SEQ ID
GTTCCACAGGCCGTGGCA
1.69

1188
1188

2816

SEQ ID
COMP ID
CATGCCACGGCCTGTGGA

4575
4592
SEQ ID
TCCACAGGCCGTGGCATG
1.65

1189
1189

2817

SEQ ID
COMP ID
CGCATGCCACGGCCTGTG

4577
4594
SEQ ID
CACAGGCCGTGGCATGCG
1.91

1190
1190

2818

SEQ ID
COMP ID
CCCGCATGCCACGGCCTG

4579
4596
SEQ ID
CAGGCCGTGGCATGCGGG
1.81

1191
1191

2819

SEQ ID
COMP ID
TCCCCGCATGCCACGGCC
520
537
4581
4598
SEQ ID
GGCCGTGGCATGCGGGGA
1.63

1192
1192

2820

SEQ ID
COMP ID
CATCCCCGCATGCCACGG
522
539
4583
4600
SEQ ID
CCGTGGCATGCGGGGATG
1.05

1193
1193

2821

SEQ ID
COMP ID
GCCATCCCCGCATGCCAC
524
541
4585
4602
SEQ ID
GTGGCATGCGGGGATGGC
1.05

1194
1194

2822

SEQ ID
COMP ID
TGGCCATCCCCGCATGCC
526
543
4587
4604
SEQ ID
GGCATGCGGGGATGGCCA
1.37

1195
1195

2823

SEQ ID
COMP ID
GATGGCCATCCCCGCATG
528
545
4589
4606
SEQ ID
CATGCGGGGATGGCCATC
1.58

1196
1196

2824

SEQ ID
COMP ID
GTGATGGCCATCCCCGCA
530
547
4591
4608
SEQ ID
TGCGGGGATGGCCATCAC
1.23

1197
1197

2825

SEQ ID
COMP ID
CAGTGATGGCCATCCCCG
532
549
4593
4610
SEQ ID
CGGGGATGGCCATCACTG
1.46

1198
1198

2826

SEQ ID
COMP ID
AGCAGTGATGGCCATCCC
534
551
4595
4612
SEQ ID
GGGATGGCCATCACTGCT
1.3

1199
1199

2827

SEQ ID
COMP ID
GCAGCAGTGATGGCCATC
536
553
4597
4614
SEQ ID
GATGGCCATCACTGCTGC
2.46

1200
1200

2828

SEQ ID
COMP ID
GGGCAGCAGTGATGGCCA
538
555
4599
4616
SEQ ID
TGGCCATCACTGCTGCCC
1.74

1201
1201

2829

SEQ ID
COMP ID
GTGGGCAGCAGTGATGGC
540
557
4601
4618
SEQ ID
GCCATCACTGCTGCCCAC
1.59

1202
1202

2830

SEQ ID
COMP ID
CCGTGGGCAGCAGTGATG
542
559
4603
4620
SEQ ID
CATCACTGCTGCCCACGG
1.66

1203
1203

2831

SEQ ID
COMP ID
CCCCGTGGGCAGCAGTGA
544
561
4605
4622
SEQ ID
TCACTGCTGCCCACGGGG
1.52

1204
1204

2832

SEQ ID
COMP ID
AGCCCCGTGGGCAGCAGT
546
563
4607
4624
SEQ ID
ACTGCTGCCCACGGGGCT
1.53

1205
1205

2833

SEQ ID
COMP ID
GAAGCCCCGTGGGCAGCA
548
565
4609
4626
SEQ ID
TGCTGCCCACGGGGCTTC
1.66

1206
1206

2834

SEQ ID
COMP ID
TGGAAGCCCCGTGGGCAG
550
567
4611
4628
SEQ ID
CTGCCCACGGGGCTTCCA
2.45

1207
1207

2835

SEQ ID
COMP ID
AGTGGAAGCCCCGTGGGC
552
569
4613
4630
SEQ ID
GCCCACGGGGCTTCCACT
1.72

1208
1208

2836

SEQ ID
COMP ID
GCAGTGGAAGCCCCGTGG
554
571
4615
4632
SEQ ID
CCACGGGGCTTCCACTGC
1.98

1209
1209

2837

SEQ ID
COMP ID
CTGCAGTGGAAGCCCCGT
556
573
4617
4634
SEQ ID
ACGGGGCTTCCACTGCAG
1.48

1210
1210

2838

SEQ ID
COMP ID
CACTGCAGTGGAAGCCCC
558
575
4619
4636
SEQ ID
GGGGCTTCCACTGCAGTG
1.31

1211
1211

2839

SEQ ID
COMP ID
TGCACTGCAGTGGAAGCC
560
577
4621
4638
SEQ ID
GGCTTCCACTGCAGTGCA
1.42

1212
1212

2840

SEQ ID
COMP ID
TCTGCACTGCAGTGGAAG
562
579
4623
4640
SEQ ID
CTTCCACTGCAGTGCAGA
1.3

1213
1213

2841

SEQ ID
COMP ID
CGTCTGCACTGCAGTGGA
564
581
4625
4642
SEQ ID
TCCACTGCAGTGCAGACG
1.35

1214
1214

2842

SEQ ID
COMP ID
CCCGTCTGCACTGCAGTG
566
583
4627
4644
SEQ ID
CACTGCAGTGCAGACGGG
1.12

1215
1215

2843

SEQ ID
COMP ID
CGCCCGTCTGCACTGCAG
568
585
4629
4646
SEQ ID
CTGCAGTGCAGACGGGCG
1.03

1216
1216

2844

SEQ ID
COMP ID
ATCGCCCGTCTGCACTGC
570
587
4631
4648
SEQ ID
GCAGTGCAGACGGGCGAT
1.05

1217
1217

2845

SEQ ID
COMP ID
GGATCGCCCGTCTGCACT
572
589
4633
4650
SEQ ID
AGTGCAGACGGGCGATCC
0.93

1218
1218

2846

SEQ ID
COMP ID
CAGGATCGCCCGTCTGCA
574
591
4635
4652
SEQ ID
TGCAGACGGGCGATCCTG
1.17

1219
1219

2847

SEQ ID
COMP ID
AGCAGGATCGCCCGTCTG
576
593
4637
4654
SEQ ID
CAGACGGGCGATCCTGCT
1.2

1220
1220

2848

SEQ ID
COMP ID
GAAGCAGGATCGCCCGTC
578
595
4639
4656
SEQ ID
GACGGGCGATCCTGCTTC
1.4

1221
1221

2849

SEQ ID
COMP ID
TGGAAGCAGGATCGCCCG
580
597
4641
4658
SEQ ID
CGGGCGATCCTGCTTCCA
1.46

1222
1222

2850

SEQ ID
COMP ID
TTTGGAAGCAGGATCGCC
582
599
4643
4660
SEQ ID
GGCGATCCTGCTTCCAAA
1.55

1223
1223

2851

SEQ ID
COMP ID
TCTTTGGAAGCAGGATCG
584
601
4645
4662
SEQ ID
CGATCCTGCTTCCAAAGA
1.62

1224
1224

2852

SEQ ID
COMP ID
GATCTTTGGAAGCAGGAT
586
603
4647
4664
SEQ ID
ATCCTGCTTCCAAAGATC
1.44

1225
1225

2853

SEQ ID
COMP ID
CTGATCTTTGGAAGCAGG
588
605
4649
4666
SEQ ID
CCTGCTTCCAAAGATCAG
1.13

1226
1226

2854

SEQ ID
COMP ID
ACCCACACCCCAGCTGCA

4668
4685
SEQ ID
TGCAGCTGGGGTGTGGGT
1.22

1227
1227

2855

SEQ ID
COMP ID
GCACCCACACCCCAGCTG

4670
4687
SEQ ID
CAGCTGGGGTGTGGGTGC
0.93

1228
1228

2856

SEQ ID
COMP ID
CTGCACCCACACCCCAGC

4672
4689
SEQ ID
GCTGGGGTGTGGGTGCAG
0.89

1229
1229

2857

SEQ ID
COMP ID
CCCTGCACCCACACCCCA

4674
4691
SEQ ID
TGGGGTGTGGGTGCAGGG
1.04

1230
1230

2858

SEQ ID
COMP ID
TGCCCTGCACCCACACCC

4676
4693
SEQ ID
GGGTGTGGGTGCAGGGCA
1.04

1231
1231

2859

SEQ ID
COMP ID
CCTGCCCTGCACCCACAC

4678
4695
SEQ ID
GTGTGGGTGCAGGGCAGG
1.22

1232
1232

2860

SEQ ID
COMP ID
TGCCTGCCCTGCACCCAC

4680
4697
SEQ ID
GTGGGTGCAGGGCAGGCA
1.14

1233
1233

2861

SEQ ID
COMP ID
TCTGCCTGCCCTGCACCC

4682
4699
SEQ ID
GGGTGCAGGGCAGGCAGA
1.19

1234
1234

2862

SEQ ID
COMP ID
CGTCTGCCTGCCCTGCAC

4684
4701
SEQ ID
GTGCAGGGCAGGCAGACG
1.42

1235
1235

2863

SEQ ID
COMP ID
CCCGTCTGCCTGCCCTGC

4686
4703
SEQ ID
GCAGGGCAGGCAGACGGG
1.09

1236
1236

2864

SEQ ID
COMP ID
TGCCCGTCTGCCTGCCCT

4688
4705
SEQ ID
AGGGCAGGCAGACGGGCA
1.27

1237
1237

2865

SEQ ID
COMP ID
GCTGCCCGTCTGCCTGCC

4690
4707
SEQ ID
GGCAGGCAGACGGGCAGC
1.56

1238
1238

2866

SEQ ID
COMP ID
ATGCTGCCCGTCTGCCTG

4692
4709
SEQ ID
CAGGCAGACGGGCAGCAT
1.38

1239
1239

2867

SEQ ID
COMP ID
CCACATGCTGCCCGTCTG

4696
4713
SEQ ID
CAGACGGGCAGCATGTGG
1.1

1240
1240

2868

SEQ ID
COMP ID
CTCCACATGCTGCCCGTC

4698
4715
SEQ ID
GACGGGCAGCATGTGGAG
1.18

1241
1241

2869

SEQ ID
COMP ID
GACTCCACATGCTGCCCG

4700
4717
SEQ ID
CGGGCAGCATGTGGAGTC
1.42

1242
1242

2870

SEQ ID
COMP ID
CCACTCAGGGAAGGTGAC

5093
5110
SEQ ID
GTCACCTTCCCTGAGTGG
1.78

1243
1243

2871

SEQ ID
COMP ID
GCCCACTCAGGGAAGGTG

5095
5112
SEQ ID
CACCTTCCCTGAGTGGGC
1.68

1244
1244

2872

SEQ ID
COMP ID
CAGCCCACTCAGGGAAGG

5097
5114
SEQ ID
CCTTCCCTGAGTGGGCTG
1.15

1245
1245

2873

SEQ ID
COMP ID
ACCAGCCCACTCAGGGAA

5099
5116
SEQ ID
TTCCCTGAGTGGGCTGGT
1

1246
1246

2874

SEQ ID
COMP ID
CTACCAGCCCACTCAGGG

5101
5118
SEQ ID
CCCTGAGTGGGCTGGTAG
1.14

1247
1247

2875

SEQ ID
COMP ID
TACTACCAGCCCACTCAG

5103
5120
SEQ ID
CTGAGTGGGCTGGTAGTA
1.14

1248
1248

2876

SEQ ID
COMP ID
GATACTACCAGCCCACTC

5105
5122
SEQ ID
GAGTGGGCTGGTAGTATC
no data

1249
1249

2877

SEQ ID
COMP ID
AGGATACTACCAGCCCAC

5107
5124
SEQ ID
GTGGGCTGGTAGTATCCT
1.23

1250
1250

2878

SEQ ID
COMP ID
CCAGGATACTACCAGCCC

5109
5126
SEQ ID
GGGCTGGTAGTATCCTGG
1.2

1251
1251

2879

SEQ ID
COMP ID
ACCCAGGATACTACCAGC

5111
5128
SEQ ID
GCTGGTAGTATCCTGGGT
1.08

1252
1252

2880

SEQ ID
COMP ID
TGACCCAGGATACTACCA

5113
5130
SEQ ID
TGGTAGTATCCTGGGTCA
1.16

1253
1253

2881

SEQ ID
COMP ID
GATGACCCAGGATACTAC

5115
5132
SEQ ID
GTAGTATCCTGGGTCATC
1.26

1254
1254

2882

SEQ ID
COMP ID
AAGATGACCCAGGATACT

5117
5134
SEQ ID
AGTATCCTGGGTCATCTT
1.16

1255
1255

2883

SEQ ID
COMP ID
ACAAGATGACCCAGGATA

5119
5136
SEQ ID
TATCCTGGGTCATCTTGT
1.17

1256
1256

2884

SEQ ID
COMP ID
GGACAAGATGACCCAGGA

5121
5138
SEQ ID
TCCTGGGTCATCTTGTCC
1.3

1257
1257

2885

SEQ ID
COMP ID
GTGGACAAGATGACCCAG

5123
5140
SEQ ID
CTGGGTCATCTTGTCCAC
1.5

1258
1258

2886

SEQ ID
COMP ID
CTGTGGACAAGATGACCC

5125
5142
SEQ ID
GGGTCATCTTGTCCACAG
1.6

1259
1259

2887

SEQ ID
COMP ID
ACCTGTGGACAAGATGAC

5127
5144
SEQ ID
GTCATCTTGTCCACAGGT
1.21

1260
1260

2888

SEQ ID
COMP ID
TTACCTGTGGACAAGATG

5129
5146
SEQ ID
CATCTTGTCCACAGGTAA
1.22

1261
1261

2889

SEQ ID
COMP ID
TGTTACCTGTGGACAAGA

5131
5148
SEQ ID
TCTTGTCCACAGGTAACA
1.69

1262
1262

2890

SEQ ID
COMP ID
GTTGTTACCTGTGGACAA

5133
5150
SEQ ID
TTGTCCACAGGTAACAAC
1.6

1263
1263

2891

SEQ ID
COMP ID
GAGTTGTTACCTGTGGAC

5135
5152
SEQ ID
GTCCACAGGTAACAACTC
1.93

1264
1264

2892

SEQ ID
COMP ID
CGGAGTTGTTACCTGTGG

5137
5154
SEQ ID
CCACAGGTAACAACTCCG
1.48

1265
1265

2893

SEQ ID
COMP ID
CACGGAGTTGTTACCTGT

5139
5156
SEQ ID
ACAGGTAACAACTCCGTG
1.41

1266
1266

2894

SEQ ID
COMP ID
CCCACGGAGTTGTTACCT
604
621
5141
5158
SEQ ID
AGGTAACAACTCCGTGGG
1.52

1267
1267

2895

SEQ ID
COMP ID
CACCCACGGAGTTGTTAC
606
623
5143
5160
SEQ ID
GTAACAACTCCGTGGGTG
1.74

1268
1268

2896

SEQ ID
COMP ID
GGCACCCACGGAGTTGTT
608
625
5145
5162
SEQ ID
AACAACTCCGTGGGTGCC
1.22

1269
1269

2897

SEQ ID
COMP ID
ATGGCACCCACGGAGTTG
610
627
5147
5164
SEQ ID
CAACTCCGTGGGTGCCAT
1.21

1270
1270

2898

SEQ ID
COMP ID
GGATGGCACCCACGGAGT
612
629
5149
5166
SEQ ID
ACTCCGTGGGTGCCATCC
1.9

1271
1271

2899

SEQ ID
COMP ID
CTGGATGGCACCCACGGA
614
631
5151
5168
SEQ ID
TCCGTGGGTGCCATCCAG
1.3

1272
1272

2900

SEQ ID
COMP ID
CACTGGATGGCACCCACG
616
633
5153
5170
SEQ ID
CGTGGGTGCCATCCAGTG
1.16

1273
1273

2901

SEQ ID
COMP ID
GGCACTGGATGGCACCCA
618
635
5155
5172
SEQ ID
TGGGTGCCATCCAGTGCC
1.31

1274
1274

2902

SEQ ID
COMP ID
AGGGCACTGGATGGCACC
620
637
5157
5174
SEQ ID
GGTGCCATCCAGTGCCCT
1.49

1275
1275

2903

SEQ ID
COMP ID
TCAGGGCACTGGATGGCA
622
639
5159
5176
SEQ ID
TGCCATCCAGTGCCCTGA
1.7

1276
1276

2904

SEQ ID
COMP ID
TATCAGGGCACTGGATGG
624
641
5161
5178
SEQ ID
CCATCCAGTGCCCTGATA
1.04

1277
1277

2905

SEQ ID
COMP ID
ACTATCAGGGCACTGGAT
626
643
5163
5180
SEQ ID
ATCCAGTGCCCTGATAGT
1.19

1278
1278

2906

SEQ ID
COMP ID
TGACTATCAGGGCACTGG
628
645
5165
5182
SEQ ID
CCAGTGCCCTGATAGTCA
1.18

1279
1279

2907

SEQ ID
COMP ID
ACTGACTATCAGGGCACT
630
647
5167
5184
SEQ ID
AGTGCCCTGATAGTCAGT
1.04

1280
1280

2908

SEQ ID
COMP ID
GAACTGACTATCAGGGCA
632
649
5169
5186
SEQ ID
TGCCCTGATAGTCAGTTC
1.08

1281
1281

2909

SEQ ID
COMP ID
TCGAACTGACTATCAGGG
634
651
5171
5188
SEQ ID
CCCTGATAGTCAGTTCGA
1.59

1282
1282

2910

SEQ ID
COMP ID
ATTCGAACTGACTATCAG
636
653
5173
5190
SEQ ID
CTGATAGTCAGTTCGAAT
1.64

1283
1283

2911

SEQ ID
COMP ID
GCATTCGAACTGACTATC
638
655
5175
5192
SEQ ID
GATAGTCAGTTCGAATGC
1.67

1284
1284

2912

SEQ ID
COMP ID
GGGCATTCGAACTGACTA
640
657
5177
5194
SEQ ID
TAGTCAGTTCGAATGCCC
1.55

1285
1285

2913

SEQ ID
COMP ID
CCGGGCATTCGAACTGAC
642
659
5179
5196
SEQ ID
GTCAGTTCGAATGCCCGG
1.81

1286
1286

2914

SEQ ID
COMP ID
GTCCGGGCATTCGAACTG
644
661
5181
5198
SEQ ID
CAGTTCGAATGCCCGGAC
1.09

1287
1287

2915

SEQ ID
COMP ID
AAGTCCGGGCATTCGAAC
646
663
5183
5200
SEQ ID
GTTCGAATGCCCGGACTT
1.62

1288
1288

2916

SEQ ID
COMP ID
AGAAGTCCGGGCATTCGA
648
665
5185
5202
SEQ ID
TCGAATGCCCGGACTTCT
1.48

1289
1289

2917

SEQ ID
COMP ID
GGAGAAGTCCGGGCATTC
650
667
5187
5204
SEQ ID
GAATGCCCGGACTTCTCC
1.8

1290
1290

2918

SEQ ID
COMP ID
GTGGAGAAGTCCGGGCAT
652
669
5189
5206
SEQ ID
ATGCCCGGACTTCTCCAC
2.43

1291
1291

2919

SEQ ID
COMP ID
ACGTGGAGAAGTCCGGGC
654
671
5191
5208
SEQ ID
GCCCGGACTTCTCCACGT
1.93

1292
1292

2920

SEQ ID
COMP ID
GCACGTGGAGAAGTCCGG
656
673
5193
5210
SEQ ID
CCGGACTTCTCCACGTGC
1.44

1293
1293

2921

SEQ ID
COMP ID
CAGCACGTGGAGAAGTCC
658
675
5195
5212
SEQ ID
GGACTTCTCCACGTGCTG
1.71

1294
1294

2922

SEQ ID
COMP ID
CACAGCACGTGGAGAAGT
660
677
5197
5214
SEQ ID
ACTTCTCCACGTGCTGTG
1.2

1295
1295

2923

SEQ ID
COMP ID
AACACAGCACGTGGAGAA
662
679
5199
5216
SEQ ID
TTCTCCACGTGCTGTGTT
1.39

1296
1296

2924

SEQ ID
COMP ID
ATAACACAGCACGTGGAG
664
681
5201
5218
SEQ ID
CTCCACGTGCTGTGTTAT
1.51

1297
1297

2925

SEQ ID
COMP ID
CCATAACACAGCACGTGG
666
683
5203
5220
SEQ ID
CCACGTGCTGTGTTATGG
1.78

1298
1298

2926

SEQ ID
COMP ID
GACCATAACACAGCACGT
668
685
5205
5222
SEQ ID
ACGTGCTGTGTTATGGTC
1.22

1299
1299

2927

SEQ ID
COMP ID
TCGACCATAACACAGCAC
670
687
5207
5224
SEQ ID
GTGCTGTGTTATGGTCGA
1.16

1300
1300

2928

SEQ ID
COMP ID
CATCGACCATAACACAGC
672
689
5209
5226
SEQ ID
GCTGTGTTATGGTCGATG
1.06

1301
1301

2929

SEQ ID
COMP ID
GCCATCGACCATAACACA
674
691
5211
5228
SEQ ID
TGTGTTATGGTCGATGGC
1.14

1302
1302

2930

SEQ ID
COMP ID
GAGCCATCGACCATAACA
676
693
5213
5230
SEQ ID
TGTTATGGTCGATGGCTC
1.29

1303
1303

2931

SEQ ID
COMP ID
AGGAGCCATCGACCATAA
678
695
5215
5232
SEQ ID
TTATGGTCGATGGCTCCT
1.52

1304
1304

2932

SEQ ID
COMP ID
CCAGGAGCCATCGACCAT
680
697
5217
5234
SEQ ID
ATGGTCGATGGCTCCTGG
0.81

1305
1305

2933

SEQ ID
COMP ID
CCCCAGGAGCCATCGACC
682
699
5219
5236
SEQ ID
GGTCGATGGCTCCTGGGG
1.3

1306
1306

2934

SEQ ID
COMP ID
ACCCCCAGGAGCCATCGA
684
701
5221
5238
SEQ ID
TCGATGGCTCCTGGGGGT
1.46

1307
1307

2935

SEQ ID
COMP ID
GCACCCCCAGGAGCCATC
686
703
5223
5240
SEQ ID
GATGGCTCCTGGGGGTGC
1.19

1308
1308

2936

SEQ ID
COMP ID
CAGCACCCCCAGGAGCCA
688
705
5225
5242
SEQ ID
TGGCTCCTGGGGGTGCTG
1.2

1309
1309

2937

SEQ ID
COMP ID
GGCAGCACCCCCAGGAGC
690
707
5227
5244
SEQ ID
GCTCCTGGGGGTGCTGCC
1.22

1310
1310

2938

SEQ ID
COMP ID
GGGGCAGCACCCCCAGGA
692
709
5229
5246
SEQ ID
TCCTGGGGGTGCTGCCCC
1.61

1311
1311

2939

SEQ ID
COMP ID
ATGGGGCAGCACCCCCAG
694
711
5231
5248
SEQ ID
CTGGGGGTGCTGCCCCAT
1.3

1312
1312

2940

SEQ ID
COMP ID
GCATGGGGCAGCACCCCC
696
713
5233
5250
SEQ ID
GGGGGTGCTGCCCCATGC
1.9

1313
1313

2941

SEQ ID
COMP ID
GGGCATGGGGCAGCACCC
698
715
5235
5252
SEQ ID
GGGTGCTGCCCCATGCCC
2.75

1314
1314

2942

SEQ ID
COMP ID
TGGGGCATGGGGCAGCAC
700
717
5237
5254
SEQ ID
GTGCTGCCCCATGCCCCA
2.3

1315
1315

2943

SEQ ID
COMP ID
TCTCCCCCAGATTTGTAC

5256
5273
SEQ ID
GTACAAATCTGGGGGAGA
1.34

1316
1316

2944

SEQ ID
COMP ID
CATCTCCCCCAGATTTGT

5258
5275
SEQ ID
ACAAATCTGGGGGAGATG
1.28

1317
1317

2945

SEQ ID
COMP ID
CCCATCTCCCCCAGATTT

5260
5277
SEQ ID
AAATCTGGGGGAGATGGG
1.33

1318
1318

2946

SEQ ID
COMP ID
CCCCCATCTCCCCCAGAT

5262
5279
SEQ ID
ATCTGGGGGAGATGGGGG
1.32

1319
1319

2947

SEQ ID
COMP ID
TACCCCCATCTCCCCCAG

5264
5281
SEQ ID
CTGGGGGAGATGGGGGTA
1.04

1320
1320

2948

SEQ ID
COMP ID
CATACCCCCATCTCCCCC

5266
5283
SEQ ID
GGGGGAGATGGGGGTATG
1.02

1321
1321

2949

SEQ ID
COMP ID
CACATACCCCCATCTCCC

5268
5285
SEQ ID
GGGAGATGGGGGTATGTG
1.05

1322
1322

2950

SEQ ID
COMP ID
TCCACATACCCCCATCTC

5270
5287
SEQ ID
GAGATGGGGGTATGTGGA
1.05

1323
1323

2951

SEQ ID
COMP ID
CCTCCACATACCCCCATC

5272
5289
SEQ ID
GATGGGGGTATGTGGAGG
0.77

1324
1324

2952

SEQ ID
COMP ID
TCCCTCCACATACCCCCA

5274
5291
SEQ ID
TGGGGGTATGTGGAGGGA
1.25

1325
1325

2953

SEQ ID
COMP ID
CTTCCCTCCACATACCCC

5276
5293
SEQ ID
GGGGTATGTGGAGGGAAG
1.03

1326
1326

2954

SEQ ID
COMP ID
CACTTCCCTCCACATACC

5278
5295
SEQ ID
GGTATGTGGAGGGAAGTG
1.29

1327
1327

2955

SEQ ID
COMP ID
CCCACTTCCCTCCACATA

5280
5297
SEQ ID
TATGTGGAGGGAAGTGGG
1.07

1328
1328

2956

SEQ ID
COMP ID
CCCCCACTTCCCTCCACA

5282
5299
SEQ ID
TGTGGAGGGAAGTGGGGG
1.21

1329
1329

2957

SEQ ID
COMP ID
TGCCCCCACTTCCCTCCA

5284
5301
SEQ ID
TGGAGGGAAGTGGGGGCA
1.12

1330
1330

2958

SEQ ID
COMP ID
TCTGCCCCCACTTCCCTC

5286
5303
SEQ ID
GAGGGAAGTGGGGGCAGA
0.97

1331
1331

2959

SEQ ID
COMP ID
ACTCTGCCCCCACTTCCC

5288
5305
SEQ ID
GGGAAGTGGGGGCAGAGT
1.08

1332
1332

2960

SEQ ID
COMP ID
CCCTGCCCCTGGCCCCCA

5306
5323
SEQ ID
TGGGGGCCAGGGGCAGGG
1.31

1333
1333

2961

SEQ ID
COMP ID
CCCCCTGCCCCTGGCCCC

5308
5325
SEQ ID
GGGGCCAGGGGCAGGGGG
0.97

1334
1334

2962

SEQ ID
COMP ID
CACCCCCTGCCCCTGGCC

5310
5327
SEQ ID
GGCCAGGGGCAGGGGGTG
1.29

1335
1335

2963

SEQ ID
COMP ID
TTCACCCCCTGCCCCTGG

5312
5329
SEQ ID
CCAGGGGCAGGGGGTGAA
1.28

1336
1336

2964

SEQ ID
COMP ID
TCTTCACCCCCTGCCCCT

5314
5331
SEQ ID
AGGGGCAGGGGGTGAAGA
1.07

1337
1337

2965

SEQ ID
COMP ID
CGTCTTCACCCCCTGCCC

5316
5333
SEQ ID
GGGCAGGGGGTGAAGACG
1.05

1338
1338

2966

SEQ ID
COMP ID
TCCGTCTTCACCCCCTGC

5318
5335
SEQ ID
GCAGGGGGTGAAGACGGA
1

1339
1339

2967

SEQ ID
COMP ID
ACTCCGTCTTCACCCCCT

5320
5337
SEQ ID
AGGGGGTGAAGACGGAGT
no data

1340
1340

2968

SEQ ID
COMP ID
TGACTCCGTCTTCACCCC

5322
5339
SEQ ID
GGGGTGAAGACGGAGTCA
1.14

1341
1341

2969

SEQ ID
COMP ID
CCTGACTCCGTCTTCACC

5324
5341
SEQ ID
GGTGAAGACGGAGTCAGG
1.14

1342
1342

2970

SEQ ID
COMP ID
GTCCTGACTCCGTCTTCA

5326
5343
SEQ ID
TGAAGACGGAGTCAGGAC
1.38

1343
1343

2971

SEQ ID
COMP ID
TGGTCCTGACTCCGTCTT

5328
5345
SEQ ID
AAGACGGAGTCAGGACCA
1.57

1344
1344

2972

SEQ ID
COMP ID
AATGGTCCTGACTCCGTC

5330
5347
SEQ ID
GACGGAGTCAGGACCATT
2.04

1345
1345

2973

SEQ ID
COMP ID
AAAATGGTCCTGACTCCG

5332
5349
SEQ ID
CGGAGTCAGGACCATTTT
2.27

1346
1346

2974

SEQ ID
COMP ID
AAAAAATGGTCCTGACTC

5334
5351
SEQ ID
GAGTCAGGACCATTTTTT
1.83

1347
1347

2975

SEQ ID
COMP ID
AGAAAAAATGGTCCTGAC

5336
5353
SEQ ID
GTCAGGACCATTTTTTCT
1.71

1348
1348

2976

SEQ ID
COMP ID
TGAGAAAAAATGGTCCTG

5338
5355
SEQ ID
CAGGACCATTTTTTCTCA
2.21

1349
1349

2977

SEQ ID
COMP ID
GTCTTCACAGCAGGAAGC
719
736
5357
5374
SEQ ID
GCTTCCTGCTGTGAAGAC
1.33

1350
1350

2978

SEQ ID
COMP ID
CTGTCTTCACAGCAGGAA
721
738
5359
5376
SEQ ID
TTCCTGCTGTGAAGACAG
1.49

1351
1351

2979

SEQ ID
COMP ID
CCCTGTCTTCACAGCAGG
723
740
5361
5378
SEQ ID
CCTGCTGTGAAGACAGGG
1.76

1352
1352

2980

SEQ ID
COMP ID
CACCCTGTCTTCACAGCA
725
742
5363
5380
SEQ ID
TGCTGTGAAGACAGGGTG
1.15

1353
1353

2981

SEQ ID
COMP ID
TGCACCCTGTCTTCACAG
727
744
5365
5382
SEQ ID
CTGTGAAGACAGGGTGCA
1.34

1354
1354

2982

SEQ ID
COMP ID
AGTGCACCCTGTCTTCAC
729
746
5367
5384
SEQ ID
GTGAAGACAGGGTGCACT
2.19

1355
1355

2983

SEQ ID
COMP ID
GCAGTGCACCCTGTCTTC
731
748
5369
5386
SEQ ID
GAAGACAGGGTGCACTGC
1.27

1356
1356

2984

SEQ ID
COMP ID
CAGCAGTGCACCCTGTCT
733
750
5371
5388
SEQ ID
AGACAGGGTGCACTGCTG
1.66

1357
1357

2985

SEQ ID
COMP ID
GACAGCAGTGCACCCTGT
735
752
5373
5390
SEQ ID
ACAGGGTGCACTGCTGTC
no data

1358
1358

2986

SEQ ID
COMP ID
CGGACAGCAGTGCACCCT
737
754
5375
5392
SEQ ID
AGGGTGCACTGCTGTCCG
no data

1359
1359

2987

SEQ ID
COMP ID
TGCGGACAGCAGTGCACC
739
756
5377
5394
SEQ ID
GGTGCACTGCTGTCCGCA
no data

1360
1360

2988

SEQ ID
COMP ID
CGTGCGGACAGCAGTGCA
741
758
5379
5396
SEQ ID
TGCACTGCTGTCCGCACG
no data

1361
1361

2989

SEQ ID
COMP ID
ACCGTGCGGACAGCAGTG
743
760
5381
5398
SEQ ID
CACTGCTGTCCGCACGGT
no data

1362
1362

2990

SEQ ID
COMP ID
GCACCGTGCGGACAGCAG
745
762
5383
5400
SEQ ID
CTGCTGTCCGCACGGTGC
no data

1363
1363

2991

SEQ ID
COMP ID
AGGCACCGTGCGGACAGC
747
764
5385
5402
SEQ ID
GCTGTCCGCACGGTGCCT
no data

1364
1364

2992

SEQ ID
COMP ID
GAAGGCACCGTGCGGACA
749
766
5387
5404
SEQ ID
TGTCCGCACGGTGCCTTC
no data

1365
1365

2993

SEQ ID
COMP ID
CAGAAGGCACCGTGCGGA
751
768
5389
5406
SEQ ID
TCCGCACGGTGCCTTCTG
no data

1366
1366

2994

SEQ ID
COMP ID
CGCAGAAGGCACCGTGCG
753
770
5391
5408
SEQ ID
CGCACGGTGCCTTCTGCG
no data

1367
1367

2995

SEQ ID
COMP ID
GTCGCAGAAGGCACCGTG
755
772
5393
5410
SEQ ID
CACGGTGCCTTCTGCGAC
no data

1368
1368

2996

SEQ ID
COMP ID
AGGTCGCAGAAGGCACCG
757
774
5395
5412
SEQ ID
CGGTGCCTTCTGCGACCT
no data

1369
1369

2997

SEQ ID
COMP ID
CCAGGTCGCAGAAGGCAC
759
776
5397
5414
SEQ ID
GTGCCTTCTGCGACCTGG
no data

1370
1370

2998

SEQ ID
COMP ID
AACCAGGTCGCAGAAGGC
761
778
5399
5416
SEQ ID
GCCTTCTGCGACCTGGTT
no data

1371
1371

2999

SEQ ID
COMP ID
TGAACCAGGTCGCAGAAG
763
780
5401
5418
SEQ ID
CTTCTGCGACCTGGTTCA
no data

1372
1372

3000

SEQ ID
COMP ID
TGTGAACCAGGTCGCAGA
765
782
5403
5420
SEQ ID
TCTGCGACCTGGTTCACA
no data

1373
1373

3001

SEQ ID
COMP ID
GGTGTGAACCAGGTCGCA
767
784
5405
5422
SEQ ID
TGCGACCTGGTTCACACC
no data

1374
1374

3002

SEQ ID
COMP ID
CGGGTGTGAACCAGGTCG
769
786
5407
5424
SEQ ID
CGACCTGGTTCACACCCG
no data

1375
1375

3003

SEQ ID
COMP ID
AGCGGGTGTGAACCAGGT
771
788
5409
5426
SEQ ID
ACCTGGTTCACACCCGCT
no data

1376
1376

3004

SEQ ID
COMP ID
GCAGCGGGTGTGAACCAG
773
790
5411
5428
SEQ ID
CTGGTTCACACCCGCTGC
no data

1377
1377

3005

SEQ ID
COMP ID
ATGCAGCGGGTGTGAACC
775
792
5413
5430
SEQ ID
GGTTCACACCCGCTGCAT
no data

1378
1378

3006

SEQ ID
COMP ID
TGATGCAGCGGGTGTGAA
777
794
5415
5432
SEQ ID
TTCACACCCGCTGCATCA
no data

1379
1379

3007

SEQ ID
COMP ID
TGTGATGCAGCGGGTGTG
779
796
5417
5434
SEQ ID
CACACCCGCTGCATCACA
no data

1380
1380

3008

SEQ ID
COMP ID
GGTGTGATGCAGCGGGTG
781
798
5419
5436
SEQ ID
CACCCGCTGCATCACACC
no data

1381
1381

3009

SEQ ID
COMP ID
TGGGTGTGATGCAGCGGG
783
800
5421
5438
SEQ ID
CCCGCTGCATCACACCCA
no data

1382
1382

3010

SEQ ID
COMP ID
CGTGGGTGTGATGCAGCG
785
802
5423
5440
SEQ ID
CGCTGCATCACACCCACG
no data

1383
1383

3011

SEQ ID
COMP ID
CCCGTGGGTGTGATGCAG
787
804
5425
5442
SEQ ID
CTGCATCACACCCACGGG
no data

1384
1384

3012

SEQ ID
COMP ID
TGCCCGTGGGTGTGATGC
789
806
5427
5444
SEQ ID
GCATCACACCCACGGGCA
no data

1385
1385

3013

SEQ ID
COMP ID
GGTGCCCGTGGGTGTGAT
791
808
5429
5446
SEQ ID
ATCACACCCACGGGCACC
no data

1386
1386

3014

SEQ ID
COMP ID
TGGGTGCCCGTGGGTGTG
793
810
5431
5448
SEQ ID
CACACCCACGGGCACCCA
no data

1387
1387

3015

SEQ ID
COMP ID
GGTGGGTGCCCGTGGGTG
795
812
5433
5450
SEQ ID
CACCCACGGGCACCCACC
no data

1388
1388

3016

SEQ ID
COMP ID
GGGGTGGGTGCCCGTGGG
797
814
5435
5452
SEQ ID
CCCACGGGCACCCACCCC
no data

1389
1389

3017

SEQ ID
COMP ID
AGGGGGTGGGTGCCCGTG
799
816
5437
5454
SEQ ID
CACGGGCACCCACCCCCT
no data

1390
1390

3018

SEQ ID
COMP ID
CCAGGGGGTGGGTGCCCG
801
818
5439
5456
SEQ ID
CGGGCACCCACCCCCTGG
no data

1391
1391

3019

SEQ ID
COMP ID
TGCCAGGGGGTGGGTGCC
803
820
5441
5458
SEQ ID
GGCACCCACCCCCTGGCA
no data

1392
1392

3020

SEQ ID
COMP ID
TTTGCCAGGGGGTGGGTG
805
822
5443
5460
SEQ ID
CACCCACCCCCTGGCAAA
no data

1393
1393

3021

SEQ ID
COMP ID
TCTTTGCCAGGGGGTGGG
807
824
5445
5462
SEQ ID
CCCACCCCCTGGCAAAGA
no data

1394
1394

3022

SEQ ID
COMP ID
CTTCTTTGCCAGGGGGTG
809
826
5447
5464
SEQ ID
CACCCCCTGGCAAAGAAG
no data

1395
1395

3023

SEQ ID
COMP ID
AGCTTCTTTGCCAGGGGG
811
828
5449
5466
SEQ ID
CCCCCTGGCAAAGAAGCT
no data

1396
1396

3024

SEQ ID
COMP ID
GGAGCTTCTTTGCCAGGG
813
830
5451
5468
SEQ ID
CCCTGGCAAAGAAGCTCC
no data

1397
1397

3025

SEQ ID
COMP ID
AGGGAGCTTCTTTGCCAG
815
832
5453
5470
SEQ ID
CTGGCAAAGAAGCTCCCT
no data

1398
1398

3026

SEQ ID
COMP ID
GCAGGGAGCTTCTTTGCC
817
834
5455
5472
SEQ ID
GGCAAAGAAGCTCCCTGC
no data

1399
1399

3027

SEQ ID
COMP ID
GGGCAGGGAGCTTCTTTG
819
836
5457
5474
SEQ ID
CAAAGAAGCTCCCTGCCC
no data

1400
1400

3028

SEQ ID
COMP ID
CTGGGCAGGGAGCTTCTT
821
838
5459
5476
SEQ ID
AAGAAGCTCCCTGCCCAG
no data

1401
1401

3029

SEQ ID
COMP ID
CTCTGGGCAGGGAGCTTC
823
840
5461
5478
SEQ ID
GAAGCTCCCTGCCCAGAG
no data

1402
1402

3030

SEQ ID
COMP ID
TCCTCTGGGCAGGGAGCT
825
842
5463
5480
SEQ ID
AGCTCCCTGCCCAGAGGA
no data

1403
1403

3031

SEQ ID
COMP ID
AGTCCTCTGGGCAGGGAG
827
844
5465
5482
SEQ ID
CTCCCTGCCCAGAGGACT
no data

1404
1404

3032

SEQ ID
COMP ID
TTAGTCCTCTGGGCAGGG
829
846
5467
5484
SEQ ID
CCCTGCCCAGAGGACTAA
no data

1405
1405

3033

SEQ ID
COMP ID
TGTTAGTCCTCTGGGCAG
831
848
5469
5486
SEQ ID
CTGCCCAGAGGACTAACA
no data

1406
1406

3034

SEQ ID
COMP ID
CCTGTTAGTCCTCTGGGC
833
850
5471
5488
SEQ ID
GCCCAGAGGACTAACAGG
no data

1407
1407

3035

SEQ ID
COMP ID
GCCCTGTTAGTCCTCTGG
835
852
5473
5490
SEQ ID
CCAGAGGACTAACAGGGC
no data

1408
1408

3036

SEQ ID
COMP ID
CTGCCCTGTTAGTCCTCT
837
854
5475
5492
SEQ ID
AGAGGACTAACAGGGCAG
no data

1409
1409

3037

SEQ ID
COMP ID
ACCTGCCCTGTTAGTCCT

5477
5494
SEQ ID
AGGACTAACAGGGCAGGT
no data

1410
1410

3038

SEQ ID
COMP ID
TCACCTGCCCTGTTAGTC

5479
5496
SEQ ID
GACTAACAGGGCAGGTGA
no data

1411
1411

3039

SEQ ID
COMP ID
CCTCACCTGCCCTGTTAG

5481
5498
SEQ ID
CTAACAGGGCAGGTGAGG
no data

1412
1412

3040

SEQ ID
COMP ID
CTCCTCACCTGCCCTGTT

5483
5500
SEQ ID
AACAGGGCAGGTGAGGAG
no data

1413
1413

3041

SEQ ID
COMP ID
ACCTCCTCACCTGCCCTG

5485
5502
SEQ ID
CAGGGCAGGTGAGGAGGT
no data

1414
1414

3042

SEQ ID
COMP ID
CCACCTCCTCACCTGCCC

5487
5504
SEQ ID
GGGCAGGTGAGGAGGTGG
no data

1415
1415

3043

SEQ ID
COMP ID
TCCCACCTCCTCACCTGC

5489
5506
SEQ ID
GCAGGTGAGGAGGTGGGA
no data

1416
1416

3044

SEQ ID
COMP ID
TCTCCCACCTCCTCACCT

5491
5508
SEQ ID
AGGTGAGGAGGTGGGAGA
no data

1417
1417

3045

SEQ ID
COMP ID
GCTCTCCCACCTCCTCAC

5493
5510
SEQ ID
GTGAGGAGGTGGGAGAGC
no data

1418
1418

3046

SEQ ID
COMP ID
ATGCTCTCCCACCTCCTC

5495
5512
SEQ ID
GAGGAGGTGGGAGAGCAT
no data

1419
1419

3047

SEQ ID
COMP ID
TGATGCTCTCCCACCTCC

5497
5514
SEQ ID
GGAGGTGGGAGAGCATCA
no data

1420
1420

3048

SEQ ID
COMP ID
CCTGATGCTCTCCCACCT

5499
5516
SEQ ID
AGGTGGGAGAGCATCAGG
no data

1421
1421

3049

SEQ ID
COMP ID
GGCCTGATGCTCTCCCAC

5501
5518
SEQ ID
GTGGGAGAGCATCAGGCC
no data

1422
1422

3050

SEQ ID
COMP ID
CTGGCCTGATGCTCTCCC

5503
5520
SEQ ID
GGGAGAGCATCAGGCCAG
no data

1423
1423

3051

SEQ ID
COMP ID
CCCTGGCCTGATGCTCTC

5505
5522
SEQ ID
GAGAGCATCAGGCCAGGG
no data

1424
1424

3052

SEQ ID
COMP ID
GCCCCTGGCCTGATGCTC

5507
5524
SEQ ID
GAGCATCAGGCCAGGGGC
1.58

1425
1425

3053

SEQ ID
COMP ID
CAGCCCCTGGCCTGATGC

5509
5526
SEQ ID
GCATCAGGCCAGGGGCTG
1.73

1426
1426

3054

SEQ ID
COMP ID
CCCAGCCCCTGGCCTGAT

5511
5528
SEQ ID
ATCAGGCCAGGGGCTGGG
1.59

1427
1427

3055

SEQ ID
COMP ID
GCCCCAGCCCCTGGCCTG

5513
5530
SEQ ID
CAGGCCAGGGGCTGGGGC
1.52

1428
1428

3056

SEQ ID
COMP ID
CCGCCCCAGCCCCTGGCC

5515
5532
SEQ ID
GGCCAGGGGCTGGGGCGG
1.14

1429
1429

3057

SEQ ID
COMP ID
CCCCGCCCCAGCCCCTGG

5517
5534
SEQ ID
CCAGGGGCTGGGGGGGG
1.58

1430
1430

3058

SEQ ID
COMP ID
GGCCCCGCCCCAGCCCCT

5519
5536
SEQ ID
AGGGGCTGGGGGGGGGCC
1.56

1431
1431

3059

SEQ ID
COMP ID
GAGGCCCCGCCCCAGCCC

5521
5538
SEQ ID
GGGCTGGGGGGGGGCCTC
1.7

1432
1432

3060

SEQ ID
COMP ID
ATGAGGCCCCGCCCCAGC

5523
5540
SEQ ID
GCTGGGGGGGGGCCTCAT
1.52

1433
1433

3061

SEQ ID
COMP ID
CAATGAGGCCCCGCCCCA

5525
5542
SEQ ID
TGGGGGGGGGCCTCATTG
1.74

1434
1434

3062

SEQ ID
COMP ID
ATGGAGGAAACTTTTTCC

5555
5572
SEQ ID
GGAAAAAGTTTCCTCCAT
1.77

1435
1435

3063

SEQ ID
COMP ID
GGATGGAGGAAACTTTTT

5557
5574
SEQ ID
AAAAAGTTTCCTCCATCC
2.6

1436
1436

3064

SEQ ID
COMP ID
CAGGATGGAGGAAACTTT

5559
5576
SEQ ID
AAAGTTTCCTCCATCCTG
1.94

1437
1437

3065

SEQ ID
COMP ID
GCCAGGATGGAGGAAACT

5561
5578
SEQ ID
AGTTTCCTCCATCCTGGC
1.72

1438
1438

3066

SEQ ID
COMP ID
CAGCCAGGATGGAGGAAA

5563
5580
SEQ ID
TTTCCTCCATCCTGGCTG
no data

1439
1439

3067

SEQ ID
COMP ID
GGCAGCCAGGATGGAGGA

5565
5582
SEQ ID
TCCTCCATCCTGGCTGCC
3.11

1440
1440

3068

SEQ ID
COMP ID
GGGGCAGCCAGGATGGAG

5567
5584
SEQ ID
CTCCATCCTGGCTGCCCC
2.65

1441
1441

3069

SEQ ID
COMP ID
GAGGGGCAGCCAGGATGG

5569
5586
SEQ ID
CCATCCTGGCTGCCCCTC
2.63

1442
1442

3070

SEQ ID
COMP ID
GTGAGGGGCAGCCAGGAT

5571
5588
SEQ ID
ATCCTGGCTGCCCCTCAC
2.15

1443
1443

3071

SEQ ID
COMP ID
ACGTGAGGGGCAGCCAGG

5573
5590
SEQ ID
CCTGGCTGCCCCTCACGT
2.66

1444
1444

3072

SEQ ID
COMP ID
AAACGTGAGGGGCAGCCA

5575
5592
SEQ ID
TGGCTGCCCCTCACGTTT
2.59

1445
1445

3073

SEQ ID
COMP ID
GCAAACGTGAGGGGCAGC

5577
5594
SEQ ID
GCTGCCCCTCACGTTTGC
3.29

1446
1446

3074

SEQ ID
COMP ID
GAGCAAACGTGAGGGGCA

5579
5596
SEQ ID
TGCCCCTCACGTTTGCTC
2.45

1447
1447

3075

SEQ ID
COMP ID
AGGAGCAAACGTGAGGGG

5581
5598
SEQ ID
CCCCTCACGTTTGCTCCT
2.77

1448
1448

3076

SEQ ID
COMP ID
AGAGGAGCAAACGTGAGG

5583
5600
SEQ ID
CCTCACGTTTGCTCCTCT
1.89

1449
1449

3077

SEQ ID
COMP ID
GAAGAGGAGCAAACGTGA

5585
5602
SEQ ID
TCACGTTTGCTCCTCTTC
1.62

1450
1450

3078

SEQ ID
COMP ID
TGGAAGAGGAGCAAACGT

5587
5604
SEQ ID
ACGTTTGCTCCTCTTCCA
2.33

1451
1451

3079

SEQ ID
COMP ID
CCGAGCTGGACAAGGCCA
855
872
5606
5623
SEQ ID
TGGCCTTGTCCAGCTCGG
1.44

1452
1452

3080

SEQ ID
COMP ID
GACCGAGCTGGACAAGGC
857
874
5608
5625
SEQ ID
GCCTTGTCCAGCTCGGTC
1.24

1453
1453

3081

SEQ ID
COMP ID
ATGACCGAGCTGGACAAG
859
876
5610
5627
SEQ ID
CTTGTCCAGCTCGGTCAT
1.75

1454
1454

3082

SEQ ID
COMP ID
ACATGACCGAGCTGGACA
861
878
5612
5629
SEQ ID
TGTCCAGCTCGGTCATGT
1.79

1455
1455

3083

SEQ ID
COMP ID
ACACATGACCGAGCTGGA
863
880
5614
5631
SEQ ID
TCCAGCTCGGTCATGTGT
2.12

1456
1456

3084

SEQ ID
COMP ID
GGACACATGACCGAGCTG
865
882
5616
5633
SEQ ID
CAGCTCGGTCATGTGTCC
1.52

1457
1457

3085

SEQ ID
COMP ID
CCGGACACATGACCGAGC
867
884
5618
5635
SEQ ID
GCTCGGTCATGTGTCCGG
1.4

1458
1458

3086

SEQ ID
COMP ID
GTCCGGACACATGACCGA
869
886
5620
5637
SEQ ID
TCGGTCATGTGTCCGGAC
1.42

1459
1459

3087

SEQ ID
COMP ID
GCGTCCGGACACATGACC
871
888
5622
5639
SEQ ID
GGTCATGTGTCCGGACGC
1.94

1460
1460

3088

SEQ ID
COMP ID
GTGCGTCCGGACACATGA
873
890
5624
5641
SEQ ID
TCATGTGTCCGGACGCAC
2.11

1461
1461

3089

SEQ ID
COMP ID
CCGTGCGTCCGGACACAT
875
392
5626
5643
SEQ ID
ATGTGTCCGGACGCACGG
1.71

1462
1462

3090

SEQ ID
COMP ID
GACCGTGCGTCCGGACAC
877
894
5628
5645
SEQ ID
GTGTCCGGACGCACGGTC
1.75

1463
1463

3091

SEQ ID
COMP ID
GGGACCGTGCGTCCGGAC
879
896
5630
5647
SEQ ID
GTCCGGACGCACGGTCCC
2.52

1464
1464

3092

SEQ ID
COMP ID
CCGGGACCGTGCGTCCGG
881
898
5632
5649
SEQ ID
CCGGACGCACGGTCCCGG
1.4

1465
1465

3093

SEQ ID
COMP ID
CACCGGGACCGTGCGTCC
883
900
5634
5651
SEQ ID
GGACGCACGGTCCCGGTG
1.09

1466
1466

3094

SEQ ID
COMP ID
GGCACCGGGACCGTGCGT
885
902
5636
5653
SEQ ID
ACGCACGGTCCCGGTGCC
2.16

1467
1467

3095

SEQ ID
COMP ID
AGGGCACCGGGACCGTGC
887
904
5638
5655
SEQ ID
GCACGGTCCCGGTGCCCT
no data

1468
1468

3096

SEQ ID
COMP ID
TCAGGGCACCGGGACCGT
889
906
5640
5657
SEQ ID
ACGGTCCCGGTGCCCTGA
1.69

1469
1469

3097

SEQ ID
COMP ID
CATCAGGGCACCGGGACC
891
908
5642
5659
SEQ ID
GGTCCCGGTGCCCTGATG
1.31

1470
1470

3098

SEQ ID
COMP ID
ACCATCAGGGCACCGGGA
893
910
5644
5661
SEQ ID
TCCCGGTGCCCTGATGGT
1.44

1471
1471

3099

SEQ ID
COMP ID
GAACCATCAGGGCACCGG
895
912
5646
5663
SEQ ID
CCGGTGCCCTGATGGTTC
1.41

1472
1472

3100

SEQ ID
COMP ID
TAGAACCATCAGGGCACC
897
914
5648
5665
SEQ ID
GGTGCCCTGATGGTTCTA
no data

1473
1473

3101

SEQ ID
COMP ID
GGTAGAACCATCAGGGCA
899
916
5650
5667
SEQ ID
TGCCCTGATGGTTCTACC
1.57

1474
1474

3102

SEQ ID
COMP ID
CAGGTAGAACCATCAGGG
901
918
5652
5669
SEQ ID
CCCTGATGGTTCTACCTG
1.18

1475
1475

3103

SEQ ID
COMP ID
AGCAGGTAGAACCATCAG
903
920
5654
5671
SEQ ID
CTGATGGTTCTACCTGCT
1.21

1476
1476

3104

SEQ ID
COMP ID
ACAGCAGGTAGAACCATC
905
922
5656
5673
SEQ ID
GATGGTTCTACCTGCTGT
1.05

1477
1477

3105

SEQ ID
COMP ID
TCACAGCAGGTAGAACCA
907
924
5658
5675
SEQ ID
TGGTTCTACCTGCTGTGA
1.79

1478
1478

3106

SEQ ID
COMP ID
GCTCACAGCAGGTAGAAC
909
926
5660
5677
SEQ ID
GTTCTACCTGCTGTGAGC
1.24

1479
1479

3107

SEQ ID
COMP ID
CAGCTCACAGCAGGTAGA
911
928
5662
5679
SEQ ID
TCTACCTGCTGTGAGCTG
1.69

1480
1480

3108

SEQ ID
COMP ID
GGCAGCTCACAGCAGGTA
913
930
5664
5681
SEQ ID
TACCTGCTGTGAGCTGCC
1.29

1481
1481

3109

SEQ ID
COMP ID
TGGGCAGCTCACAGCAGG
915
932
5666
5683
SEQ ID
CCTGCTGTGAGCTGCCCA
1.65

1482
1482

3110

SEQ ID
COMP ID
ACTGGGCAGCTCACAGCA
917
934
5668
5685
SEQ ID
TGCTGTGAGCTGCCCAGT
0.89

1483
1483

3111

SEQ ID
COMP ID
CCACTGGGCAGCTCACAG
919
936
5670
5687
SEQ ID
CTGTGAGCTGCCCAGTGG
1.26

1484
1484

3112

SEQ ID
COMP ID
TCCCACTGGGCAGCTCAC
921
938
5672
5689
SEQ ID
GTGAGCTGCCCAGTGGGA
1.4

1485
1485

3113

SEQ ID
COMP ID
CTTCCCACTGGGCAGCTC
923
940
5674
5691
SEQ ID
GAGCTGCCCAGTGGGAAG
no data

1486
1486

3114

SEQ ID
COMP ID
TACTTCCCACTGGGCAGC
925
942
5676
5693
SEQ ID
GCTGCCCAGTGGGAAGTA
1.37

1487
1487

3115

SEQ ID
COMP ID
CATACTTCCCACTGGGCA
927
944
5678
5695
SEQ ID
TGCCCAGTGGGAAGTATG
1.5

1488
1488

3116

SEQ ID
COMP ID
GCCATACTTCCCACTGGG
929
946
5680
5697
SEQ ID
CCCAGTGGGAAGTATGGC
1.08

1489
1489

3117

SEQ ID
COMP ID
CAGCCATACTTCCCACTG
931
948
5682
5699
SEQ ID
CAGTGGGAAGTATGGCTG
0.8

1490
1490

3118

SEQ ID
COMP ID
AGCAGCCATACTTCCCAC
933
950
5684
5701
SEQ ID
GTGGGAAGTATGGCTGCT
1.06

1491
1491

3119

SEQ ID
COMP ID
GCAGCAGCCATACTTCCC
935
952
5686
5703
SEQ ID
GGGAAGTATGGCTGCTGC
1.59

1492
1492

3120

SEQ ID
COMP ID
GGGCAGCAGCCATACTTC
937
954
5688
5705
SEQ ID
GAAGTATGGCTGCTGCCC
1.95

1493
1493

3121

SEQ ID
COMP ID
TTGGGCAGCAGCCATACT
939
956
5690
5707
SEQ ID
AGTATGGCTGCTGCCCAA
1.36

1494
1494

3122

SEQ ID
COMP ID
CATTGGGCAGCAGCCATA
941
958
5692
5709
SEQ ID
TATGGCTGCTGCCCAATG
1.36

1495
1495

3123

SEQ ID
COMP ID
GGCATTGGGCAGCAGCCA
943
960
5694
5711
SEQ ID
TGGCTGCTGCCCAATGCC
1.49

1496
1496

3124

SEQ ID
COMP ID
TGGGCATTGGGCAGCAGC
945
962
5696
5713
SEQ ID
GCTGCTGCCCAATGCCCA
1.56

1497
1497

3125

SEQ ID
COMP ID
GTTGGGCATTGGGCAGCA
947
964
5698
5715
SEQ ID
TGCTGCCCAATGCCCAAC
1.56

1498
1498

3126

SEQ ID
COMP ID
GCTCCAGCCCCTCACTCA

5717
5734
SEQ ID
TGAGTGAGGGGCTGGAGC
1.37

1499
1499

3127

SEQ ID
COMP ID
TGGCTCCAGCCCCTCACT

5719
5736
SEQ ID
AGTGAGGGGCTGGAGCCA
1.21

1500
1500

3128

SEQ ID
COMP ID
GCTGGCTCCAGCCCCTCA

5721
5738
SEQ ID
TGAGGGGCTGGAGCCAGC
1.23

1501
1501

3129

SEQ ID
COMP ID
AAGCTGGCTCCAGCCCCT

5723
5740
SEQ ID
AGGGGCTGGAGCCAGCTT
1.16

1502
1502

3130

SEQ ID
COMP ID
CCAAGCTGGCTCCAGCCC

5725
5742
SEQ ID
GGGCTGGAGCCAGCTTGG
1.06

1503
1503

3131

SEQ ID
COMP ID
AGCCAAGCTGGCTCCAGC

5727
5744
SEQ ID
GCTGGAGCCAGCTTGGCT
1.25

1504
1504

3132

SEQ ID
COMP ID
ACAGCCAAGCTGGCTCCA

5729
5746
SEQ ID
TGGAGCCAGCTTGGCTGT
1.75

1505
1505

3133

SEQ ID
COMP ID
ACACAGCCAAGCTGGCTC

5731
5748
SEQ ID
GAGCCAGCTTGGCTGTGT
1.96

1506
1506

3134

SEQ ID
COMP ID
GCACACAGCCAAGCTGGC

5733
5750
SEQ ID
GCCAGCTTGGCTGTGTGC
1.7

1507
1507

3135

SEQ ID
COMP ID
GGGCACACAGCCAAGCTG

5735
5752
SEQ ID
CAGCTTGGCTGTGTGCCC
1.38

1508
1508

3136

SEQ ID
COMP ID
GGGGGCACACAGCCAAGC

5737
5754
SEQ ID
GCTTGGCTGTGTGCCCCC
2.09

1509
1509

3137

SEQ ID
COMP ID
CTGGGGGCACACAGCCAA

5739
5756
SEQ ID
TTGGCTGTGTGCCCCCAG
2.15

1510
1510

3138

SEQ ID
COMP ID
GGCTGGGGGCACACAGCC

5741
5758
SEQ ID
GGCTGTGTGCCCCCAGCC
1.46

1511
1511

3139

SEQ ID
COMP ID
GTGGCTGGGGGCACACAG

5743
5760
SEQ ID
CTGTGTGCCCCCAGCCAC
1.67

1512
1512

3140

SEQ ID
COMP ID
AGGTGGCTGGGGGCACAC

5745
5762
SEQ ID
GTGTGCCCCCAGCCACCT
2.14

1513
1513

3141

SEQ ID
COMP ID
CCAGGTGGCTGGGGGCAC

5747
5764
SEQ ID
GTGCCCCCAGCCACCTGG
1.51

1514
1514

3142

SEQ ID
COMP ID
GGCCAGGTGGCTGGGGGC

5749
5766
SEQ ID
GCCCCCAGCCACCTGGCC
2.43

1515
1515

3143

SEQ ID
COMP ID
CCAGCCCCATGCCACAGA

5789
5806
SEQ ID
TCTGTGGCATGGGGCTGG
1.27

1516
1516

3144

SEQ ID
COMP ID
AGCCAGCCCCATGCCACA

5791
5808
SEQ ID
TGTGGCATGGGGCTGGCT
1.56

1517
1517

3145

SEQ ID
COMP ID
CCAGCCAGCCCCATGCCA

5793
5810
SEQ ID
TGGCATGGGGCTGGCTGG
1.14

1518
1518

3146

SEQ ID
COMP ID
CCTGCATCAGCCAGGCTC

5822
5839
SEQ ID
GAGCCTGGCTGATGCAGG
1.44

1519
1519

3147

SEQ ID
COMP ID
ACCCTGCATCAGCCAGGC

5824
5841
SEQ ID
GCCTGGCTGATGCAGGGT
1.56

1520
1520

3148

SEQ ID
COMP ID
GAACCCTGCATCAGCCAG

5826
5843
SEQ ID
CTGGCTGATGCAGGGTTC
1.22

1521
1521

3149

SEQ ID
COMP ID
ATGAACCCTGCATCAGCC

5828
5845
SEQ ID
GGCTGATGCAGGGTTCAT
1.37

1522
1522

3150

SEQ ID
COMP ID
TCCAGGCTCAGTAGCACA

5902
5919
SEQ ID
TGTGCTACTGAGCCTGGA
1.43

1523
1523

3151

SEQ ID
COMP ID
CTTCCAGGCTCAGTAGCA

5904
5921
SEQ ID
TGCTACTGAGCCTGGAAG
1.76

1524
1524

3152

SEQ ID
COMP ID
CACTTCCAGGCTCAGTAG

5906
5923
SEQ ID
CTACTGAGCCTGGAAGTG
1.52

1525
1525

3153

SEQ ID
COMP ID
GTCACTTCCAGGCTCAGT

5908
5925
SEQ ID
ACTGAGCCTGGAAGTGAC
1.48

1526
1526

3154

SEQ ID
COMP ID
TTGTCACTTCCAGGCTCA

5910
5927
SEQ ID
TGAGCCTGGAAGTGACAA
1.47

1527
1527

3155

SEQ ID
COMP ID
CTTTGTCACTTCCAGGCT

5912
5929
SEQ ID
AGCCTGGAAGTGACAAAG
1.78

1528
1528

3156

SEQ ID
COMP ID
GTCTTTGTCACTTCCAGG

5914
5931
SEQ ID
CCTGGAAGTGACAAAGAC
1.55

1529
1529

3157

SEQ ID
COMP ID
GGGTCTTTGTCACTTCCA

5916
5933
SEQ ID
TGGAAGTGACAAAGACCC
2.02

1530
1530

3158

SEQ ID
COMP ID
GTGGGTCTTTGTCACTTC

5918
5935
SEQ ID
GAAGTGACAAAGACCCAC
1.94

1531
1531

3159

SEQ ID
COMP ID
GGGTGGGTCTTTGTCACT

5920
5937
SEQ ID
AGTGACAAAGACCCACCC
1.91

1532
1532

3160

SEQ ID
COMP ID
AGGGGTGGGTCTTTGTCA

5922
5939
SEQ ID
TGACAAAGACCCACCCCT
2.21

1533
1533

3161

SEQ ID
COMP ID
ACAGGGGTGGGTCTTTGT

5924
5941
SEQ ID
ACAAAGACCCACCCCTGT
2.12

1534
1534

3162

SEQ ID
COMP ID
GGACAGGGGTGGGTCTTT

5926
5943
SEQ ID
AAAGACCCACCCCTGTCC
2.22

1535
1535

3163

SEQ ID
COMP ID
GGGGACAGGGGTGGGTCT

5928
5945
SEQ ID
AGACCCACCCCTGTCCCC
2.37

1536
1536

3164

SEQ ID
COMP ID
GTGGGGACAGGGGTGGGT

5930
5947
SEQ ID
ACCCACCCCTGTCCCCAC
2.32

1537
1537

3165

SEQ ID
COMP ID
GAGTGGGGACAGGGGTGG

5932
5949
SEQ ID
CCACCCCTGTCCCCACTC
2.82

1538
1538

3166

SEQ ID
COMP ID
CTGAGTGGGGACAGGGGT

5934
5951
SEQ ID
ACCCCTGTCCCCACTCAG
2.26

1539
1539

3167

SEQ ID
COMP ID
GATCGGAGCAGCAGGTGG
966
983
5953
5970
SEQ ID
CCACCTGCTGCTCCGATC
2.03

1540
1540

3168

SEQ ID
COMP ID
GTGATCGGAGCAGCAGGT
968
985
5955
5972
SEQ ID
ACCTGCTGCTCCGATCAC
1.66

1541
1541

3169

SEQ ID
COMP ID
AGGTGATCGGAGCAGCAG
970
987
5957
5974
SEQ ID
CTGCTGCTCCGATCACCT
2

1542
1542

3170

SEQ ID
COMP ID
GCAGGTGATCGGAGCAGC
972
989
5959
5976
SEQ ID
GCTGCTCCGATCACCTGC
1.32

1543
1543

3171

SEQ ID
COMP ID
GTGCAGGTGATCGGAGCA
974
991
5961
5978
SEQ ID
TGCTCCGATCACCTGCAC
1.62

1544
1544

3172

SEQ ID
COMP ID
CAGTGCAGGTGATCGGAG
976
993
5963
5980
SEQ ID
CTCCGATCACCTGCACTG
2.12

1545
1545

3173

SEQ ID
COMP ID
AGCAGTGCAGGTGATCGG
978
995
5965
5982
SEQ ID
CCGATCACCTGCACTGCT
1.58

1546
1546

3174

SEQ ID
COMP ID
GCAGCAGTGCAGGTGATC
980
997
5967
5984
SEQ ID
GATCACCTGCACTGCTGC
1.83

1547
1547

3175

SEQ ID
COMP ID
GGGCAGCAGTGCAGGTGA
982
999
5969
5986
SEQ ID
TCACCTGCACTGCTGCCC
2.37

1548
1548

3176

SEQ ID
COMP ID
GGGGGCAGCAGTGCAGGT
984
1001
5971
5988
SEQ ID
ACCTGCACTGCTGCCCCC
2.03

1549
1549

3177

SEQ ID
COMP ID
TTGGGGGCAGCAGTGCAG
986
1003
5973
5990
SEQ ID
CTGCACTGCTGCCCCCAA
1.99

1550
1550

3178

SEQ ID
COMP ID
TCTTGGGGGCAGCAGTGC
988
1005
5975
5992
SEQ ID
GCACTGCTGCCCCCAAGA
1.77

1551
1551

3179

SEQ ID
COMP ID
TGTCTTGGGGGCAGCAGT
990
1007
5977
5994
SEQ ID
ACTGCTGCCCCCAAGACA
1.68

1552
1552

3180

SEQ ID
COMP ID
AGTGTCTTGGGGGCAGCA
992
1009
5979
5996
SEQ ID
TGCTGCCCCCAAGACACT
2.12

1553
1553

3181

SEQ ID
COMP ID
ACAGTGTCTTGGGGGCAG
994
1011
5981
5998
SEQ ID
CTGCCCCCAAGACACTGT
1.93

1554
1554

3182

SEQ ID
COMP ID
ACACAGTGTCTTGGGGGC
996
1013
5983
6000
SEQ ID
GCCCCCAAGACACTGTGT
2.21

1555
1555

3183

SEQ ID
COMP ID
ACACACAGTGTCTTGGGG
998
1015
5985
6002
SEQ ID
CCCCAAGACACTGTGTGT
1.79

1556
1556

3184

SEQ ID
COMP ID
TCACACACAGTGTCTTGG
1000
1017
5987
6004
SEQ ID
CCAAGACACTGTGTGTGA
1.39

1557
1557

3185

SEQ ID
COMP ID
GGTCACACACAGTGTCTT
1002
1019
5989
6006
SEQ ID
AAGACACTGTGTGTGACC
1.72

1558
1558

3186

SEQ ID
COMP ID
CAGGTCACACACAGTGTC
1004
1021
5991
6008
SEQ ID
GACACTGTGTGTGACCTG
1.43

1559
1559

3187

SEQ ID
COMP ID
ATCAGGTCACACACAGTG
1006
1023
5993
6010
SEQ ID
CACTGTGTGTGACCTGAT
1.63

1560
1560

3188

SEQ ID
COMP ID
GGATCAGGTCACACACAG
1008
1025
5995
6012
SEQ ID
CTGTGTGTGACCTGATCC
1.44

1561
1561

3189

SEQ ID
COMP ID
CTGGATCAGGTCACACAC
1010
1027
5997
6014
SEQ ID
GTGTGTGACCTGATCCAG
1.15

1562
1562

3190

SEQ ID
COMP ID
CTCTGGATCAGGTCACAC
1012
1029
5999
6016
SEQ ID
GTGTGACCTGATCCAGAG
1.56

1563
1563

3191

SEQ ID
COMP ID
TACTCTGGATCAGGTCAC
1014
1031
6001
6018
SEQ ID
GTGACCTGATCCAGAGTA
1.45

1564
1564

3192

SEQ ID
COMP ID
CTTACTCTGGATCAGGTC
1016
1033
6003
6020
SEQ ID
GACCTGATCCAGAGTAAG
1.51

1565
1565

3193

SEQ ID
COMP ID
CACTTACTCTGGATCAGG
1018
1035
6005
6022
SEQ ID
CCTGATCCAGAGTAAGTG
1.39

1566
1566

3194

SEQ ID
COMP ID
GGCACTTACTCTGGATCA
1020
1037
6007
6024
SEQ ID
TGATCCAGAGTAAGTGCC
1.28

1567
1567

3195

SEQ ID
COMP ID
GAGGCACTTACTCTGGAT
1022
1039
6009
6026
SEQ ID
ATCCAGAGTAAGTGCCTC
1.53

1568
1568

3196

SEQ ID
COMP ID
GAGAGGCACTTACTCTGG
1024
1041
6011
6028
SEQ ID
CCAGAGTAAGTGCCTCTC
1.5

1569
1569

3197

SEQ ID
COMP ID
TGGAGAGGCACTTACTCT
1026
1043
6013
6030
SEQ ID
AGAGTAAGTGCCTCTCCA
1.39

1570
1570

3198

SEQ ID
COMP ID
CTTGGAGAGGCACTTACT
1028
1045
6015
6032
SEQ ID
AGTAAGTGCCTCTCCAAG
1.37

1571
1571

3199

SEQ ID
COMP ID
TCCTTGGAGAGGCACTTA
1030
1047
6017
6034
SEQ ID
TAAGTGCCTCTCCAAGGA
1.3

1572
1572

3200

SEQ ID
COMP ID
TCTCCTTGGAGAGGCACT
1032
1049
6019
6036
SEQ ID
AGTGCCTCTCCAAGGAGA
1.26

1573
1573

3201

SEQ ID
COMP ID
GTTCTCCTTGGAGAGGCA
1034
1051
6021
6038
SEQ ID
TGCCTCTCCAAGGAGAAC
1.17

1574
1574

3202

SEQ ID
COMP ID
GCGTTCTCCTTGGAGAGG
1036
1053
6023
6040
SEQ ID
CCTCTCCAAGGAGAACGC
1.65

1575
1575

3203

SEQ ID
COMP ID
TAGCGTTCTCCTTGGAGA
1038
1055
6025
6042
SEQ ID
TCTCCAAGGAGAACGCTA
1.36

1576
1576

3204

SEQ ID
COMP ID
GGTAGCGTTCTCCTTGGA
1040
1057
6027
6044
SEQ ID
TCCAAGGAGAACGCTACC
1.86

1577
1577

3205

SEQ ID
COMP ID
GTGGTAGCGTTCTCCTTG
1042
1059
6029
6046
SEQ ID
CAAGGAGAACGCTACCAC
1.81

1578
1578

3206

SEQ ID
COMP ID
CCGTGGTAGCGTTCTCCT
1044
1061
6031
6048
SEQ ID
AGGAGAACGCTACCACGG
1.52

1579
1579

3207

SEQ ID
COMP ID
GTCCGTGGTAGCGTTCTC
1046
1063
6033
6050
SEQ ID
GAGAACGCTACCACGGAC
1.3

1580
1580

3208

SEQ ID
COMP ID
AGGTCCGTGGTAGCGTTC
1048
1065
6035
6052
SEQ ID
GAACGCTACCACGGACCT
1.25

1581
1581

3209

SEQ ID
COMP ID
GGAGGTCCGTGGTAGCGT
1050
1067
6037
6054
SEQ ID
ACGCTACCACGGACCTCC
2.11

1582
1582

3210

SEQ ID
COMP ID
GAGGAGGTCCGTGGTAGC
1052
1069
6039
6056
SEQ ID
GCTACCACGGACCTCCTC
2.26

1583
1583

3211

SEQ ID
COMP ID
GTGAGGAGGTCCGTGGTA
1054
1071
6041
6058
SEQ ID
TACCACGGACCTCCTCAC
1.9

1584
1584

3212

SEQ ID
COMP ID
TAGTGAGGAGGTCCGTGG
1056
1073
6043
6060
SEQ ID
CCACGGACCTCCTCACTA
1.88

1585
1585

3213

SEQ ID
COMP ID
CTTAGTGAGGAGGTCCGT
1058
1075
6045
6062
SEQ ID
ACGGACCTCCTCACTAAG
1.88

1586
1586

3214

SEQ ID
COMP ID
AGCTTAGTGAGGAGGTCC
1060
1077
6047
6064
SEQ ID
GGACCTCCTCACTAAGCT
1.83

1587
1587

3215

SEQ ID
COMP ID
GCAGCTTAGTGAGGAGGT
1062
1079
6049
6066
SEQ ID
ACCTCCTCACTAAGCTGC
2.35

1588
1588

3216

SEQ ID
COMP ID
AGGCAGCTTAGTGAGGAG
1064
1081
6051
6068
SEQ ID
CTCCTCACTAAGCTGCCT
1.97

1589
1589

3217

SEQ ID
COMP ID
GCAGGCAGCTTAGTGAGG
1066
1083
6053
6070
SEQ ID
CCTCACTAAGCTGCCTGC
2.13

1590
1590

3218

SEQ ID
COMP ID
GCGCAGGCAGCTTAGTGA
1068
1085
6055
6072
SEQ ID
TCACTAAGCTGCCTGCGC
2.16

1591
1591

3219

SEQ ID
COMP ID
GTGCGCAGGCAGCTTAGT
1070
1087
6057
6074
SEQ ID
ACTAAGCTGCCTGCGCAC
1.48

1592
1592

3220

SEQ ID
COMP ID
GTGTGCGCAGGCAGCTTA
1072
1089
6059
6076
SEQ ID
TAAGCTGCCTGCGCACAC
1.67

1593
1593

3221

SEQ ID
COMP ID
CTGTGTGCGCAGGCAGCT
1074
1091
6061
6078
SEQ ID
AGCTGCCTGCGCACACAG
1.67

1594
1594

3222

SEQ ID
COMP ID
TGCACCCTGCCTCTGGTA

6080
6097
SEQ ID
TACCAGAGGCAGGGTGCA
1.72

1595
1595

3223

SEQ ID
COMP ID
TCTGCACCCTGCCTCTGG

6082
6099
SEQ ID
CCAGAGGCAGGGTGCAGA
1.74

1596
1596

3224

SEQ ID
COMP ID
TATCTGCACCCTGCCTCT

6084
6101
SEQ ID
AGAGGCAGGGTGCAGATA
1.38

1597
1597

3225

SEQ ID
COMP ID
TGTATCTGCACCCTGCCT

6086
6103
SEQ ID
AGGCAGGGTGCAGATACA
1.36

1598
1598

3226

SEQ ID
COMP ID
CCTGTATCTGCACCCTGC

6088
6105
SEQ ID
GCAGGGTGCAGATACAGG
1.62

1599
1599

3227

SEQ ID
COMP ID
CCCCTGTATCTGCACCCT

6090
6107
SEQ ID
AGGGTGCAGATACAGGGG
1.31

1600
1600

3228

SEQ ID
COMP ID
CACCCCTGTATCTGCACC

6092
6109
SEQ ID
GGTGCAGATACAGGGGTG
1.13

1601
1601

3229

SEQ ID
COMP ID
CCCACCCCTGTATCTGCA

6094
6111
SEQ ID
TGCAGATACAGGGGTGGG
1.11

1602
1602

3230

SEQ ID
COMP ID
GCCCCACCCCTGTATCTG

6096
6113
SEQ ID
CAGATACAGGGGTGGGGC
1.38

1603
1603

3231

SEQ ID
COMP ID
GGGCCCCACCCCTGTATC

6098
6115
SEQ ID
GATACAGGGGTGGGGCCC
1.42

1604
1604

3232

SEQ ID
COMP ID
GGGGGCCCCACCCCTGTA

6100
6117
SEQ ID
TACAGGGGTGGGGCCCCC
1.14

1605
1605

3233

SEQ ID
COMP ID
AAGGGGGCCCCACCCCTG

6102
6119
SEQ ID
CAGGGGTGGGGCCCCCTT
1.16

1606
1606

3234

SEQ ID
COMP ID
GAAAGGGGGCCCCACCCC

6104
6121
SEQ ID
GGGGTGGGGCCCCCTTTC
1.34

1607
1607

3235

SEQ ID
COMP ID
AGGAAAGGGGGCCCCACC

6106
6123
SEQ ID
GGTGGGGCCCCCTTTCCT
1.74

1608
1608

3236

SEQ ID
COMP ID
GGAGGAAAGGGGGCCCCA

6108
6125
SEQ ID
TGGGGCCCCCTTTCCTCC
2.14

1609
1609

3237

SEQ ID
COMP ID
AGGGAGGAAAGGGGGCCC

6110
6127
SEQ ID
GGGCCCCCTTTCCTCCCT
2.26

1610
1610

3238

SEQ ID
COMP ID
AAAGGGAGGAAAGGGGGC

6112
6129
SEQ ID
GCCCCCTTTCCTCCCTTT
2.14

1611
1611

3239

SEQ ID
COMP ID
TAAAAGGGAGGAAAGGGG

6114
6131
SEQ ID
CCCCTTTCCTCCCTTTTA
2.13

1612
1612

3240

SEQ ID
COMP ID
CCTAAAAGGGAGGAAAGG

6116
6133
SEQ ID
CCTTTCCTCCCTTTTAGG
1.65

1613
1613

3241

SEQ ID
COMP ID
GGCCTAAAAGGGAGGAAA

6118
6135
SEQ ID
TTTCCTCCCTTTTAGGCC
2.24

1614
1614

3242

SEQ ID
COMP ID
CAGGCCTAAAAGGGAGGA

6120
6137
SEQ ID
TCCTCCCTTTTAGGCCTG
1.97

1615
1615

3243

SEQ ID
COMP ID
GCCAGGCCTAAAAGGGAG

6122
6139
SEQ ID
CTCCCTTTTAGGCCTGGC
1.76

1616
1616

3244

SEQ ID
COMP ID
AGGCCAGGCCTAAAAGGG

6124
6141
SEQ ID
CCCTTTTAGGCCTGGCCT
1.76

1617
1617

3245

SEQ ID
COMP ID
TAAGGCCAGGCCTAAAAG

6126
6143
SEQ ID
CTTTTAGGCCTGGCCTTA
1.9

1618
1618

3246

SEQ ID
COMP ID
CCTAAGGCCAGGCCTAAA

6128
6145
SEQ ID
TTTAGGCCTGGCCTTAGG
0.98

1619
1619

3247

SEQ ID
COMP ID
ATCCTAAGGCCAGGCCTA

6130
6147
SEQ ID
TAGGCCTGGCCTTAGGAT
1.56

1620
1620

3248

SEQ ID
COMP ID
TGATCCTAAGGCCAGGCC

6132
6149
SEQ ID
GGCCTGGCCTTAGGATCA
1.63

1621
1621

3249

SEQ ID
COMP ID
AGTGATCCTAAGGCCAGG

6134
6151
SEQ ID
CCTGGCCTTAGGATCACT
2.63

1622
1622

3250

SEQ ID
COMP ID
GCAGTGATCCTAAGGCCA

6136
6153
SEQ ID
TGGCCTTAGGATCACTGC
2.04

1623
1623

3251

SEQ ID
COMP ID
TTGCAGTGATCCTAAGGC

6138
6155
SEQ ID
GCCTTAGGATCACTGCAA
1.74

1624
1624

3252

SEQ ID
COMP ID
CCTTGCAGTGATCCTAAG

6140
6157
SEQ ID
CTTAGGATCACTGCAAGG
1.33

1625
1625

3253

SEQ ID
COMP ID
CACCTTGCAGTGATCCTA

6142
6159
SEQ ID
TAGGATCACTGCAAGGTG
1.55

1626
1626

3254

SEQ ID
COMP ID
ACCACCTTGCAGTGATCC

6144
6161
SEQ ID
GGATCACTGCAAGGTGGT
1.42

1627
1627

3255

SEQ ID
COMP ID
ACACCACCTTGCAGTGAT

6146
6163
SEQ ID
ATCACTGCAAGGTGGTGT
1.38

1628
1628

3256

SEQ ID
COMP ID
GGCACTGGGGACCCTCAG

6227
6244
SEQ ID
CTGAGGGTCCCCAGTGCC
1.18

1629
1629

3257

SEQ ID
COMP ID
GTGGCACTGGGGACCCTC

6229
6246
SEQ ID
GAGGGTCCCCAGTGCCAC
1.87

1630
1630

3258

SEQ ID
COMP ID
AAGTGGCACTGGGGACCC

6231
6248
SEQ ID
GGGTCCCCAGTGCCACTT
1.76

1631
1631

3259

SEQ ID
COMP ID
AGAAGTGGCACTGGGGAC

6233
6250
SEQ ID
GTCCCCAGTGCCACTTCT
1.3

1632
1632

3260

SEQ ID
COMP ID
TCAGAAGTGGCACTGGGG

6235
6252
SEQ ID
CCCCAGTGCCACTTCTGA
1.77

1633
1633

3261

SEQ ID
COMP ID
GGTCAGAAGTGGCACTGG

6237
6254
SEQ ID
CCAGTGCCACTTCTGACC
1.03

1634
1634

3262

SEQ ID
COMP ID
CAGGTCAGAAGTGGCACT

6239
6256
SEQ ID
AGTGCCACTTCTGACCTG
1.5

1635
1635

3263

SEQ ID
COMP ID
GACAGGTCAGAAGTGGCA

6241
6258
SEQ ID
TGCCACTTCTGACCTGTC
1.33

1636
1636

3264

SEQ ID
COMP ID
AGGACAGGTCAGAAGTGG

6243
6260
SEQ ID
CCACTTCTGACCTGTCCT
1.75

1637
1637

3265

SEQ ID
COMP ID
AGAGGACAGGTCAGAAGT

6245
6262
SEQ ID
ACTTCTGACCTGTCCTCT
1.75

1638
1638

3266

SEQ ID
COMP ID
AGAGAGGACAGGTCAGAA

6247
6264
SEQ ID
TTCTGACCTGTCCTCTCT
2.2

1639
1639

3267

SEQ ID
COMP ID
GCAGAGAGGACAGGTCAG

6249
6266
SEQ ID
CTGACCTGTCCTCTCTGC
1.36

1640
1640

3268

SEQ ID
COMP ID
AAGCAGAGAGGACAGGTC

6251
6268
SEQ ID
GACCTGTCCTCTCTGCTT
1.35

1641
1641

3269

SEQ ID
COMP ID
GGAAGCAGAGAGGACAGG

6253
6270
SEQ ID
CCTGTCCTCTCTGCTTCC
1.41

1642
1642

3270

SEQ ID
COMP ID
AGGGAAGCAGAGAGGACA

6255
6272
SEQ ID
TGTCCTCTCTGCTTCCCT
1.51

1643
1643

3271

SEQ ID
COMP ID
TGAGGGAAGCAGAGAGGA

6257
6274
SEQ ID
TCCTCTCTGCTTCCCTCA
1.87

1644
1644

3272

SEQ ID
COMP ID
TGTGAGGGAAGCAGAGAG

6259
6276
SEQ ID
CTCTCTGCTTCCCTCACA
1.55

1645
1645

3273

SEQ ID
COMP ID
CACATTTCACATCCCCCA
1092
1109
6278
6295
SEQ ID
TGGGGGATGTGAAATGTG
0.93

1646
1646

3274

SEQ ID
COMP ID
GTCACATTTCACATCCCC
1094
1111
6280
6297
SEQ ID
GGGGATGTGAAATGTGAC
1.29

1647
1647

3275

SEQ ID
COMP ID
ATGTCACATTTCACATCC
1096
1113
6282
6299
SEQ ID
GGATGTGAAATGTGACAT
1.64

1648
1648

3276

SEQ ID
COMP ID
CCATGTCACATTTCACAT
1098
1115
6284
6301
SEQ ID
ATGTGAAATGTGACATGG
1.52

1649
1649

3277

SEQ ID
COMP ID
CTCCATGTCACATTTCAC
1100
1117
6286
6303
SEQ ID
GTGAAATGTGACATGGAG
1.44

1650
1650

3278

SEQ ID
COMP ID
ACCTCCATGTCACATTTC
1102
1119
6288
6305
SEQ ID
GAAATGTGACATGGAGGT
1.54

1651
1651

3279

SEQ ID
COMP ID
TCACCTCCATGTCACATT
1104
1121
6290
6307
SEQ ID
AATGTGACATGGAGGTGA
1.1

1652
1652

3280

SEQ ID
COMP ID
GCTCACCTCCATGTCACA
1106
1123
6292
6309
SEQ ID
TGTGACATGGAGGTGAGC
0.93

1653
1653

3281

SEQ ID
COMP ID
CAGCTCACCTCCATGTCA
1108
1125
6294
6311
SEQ ID
TGACATGGAGGTGAGCTG
.21

1654
1654

3282

SEQ ID
COMP ID
GGCAGCTCACCTCCATGT
1110
1127
6296
6313
SEQ ID
ACATGGAGGTGAGCTGCC
0.93

1655
1655

3283

SEQ ID
COMP ID
TGGGCAGCTCACCTCCAT
1112
1129
6298
6315
SEQ ID
ATGGAGGTGAGCTGCCCA
1.04

1656
1656

3284

SEQ ID
COMP ID
TCTGGGCAGCTCACCTCC
1114
1131
6300
6317
SEQ ID
GGAGGTGAGCTGCCCAGA
1.3

1657
1657

3285

SEQ ID
COMP ID
CATCTGGGCAGCTCACCT
1116
1133
6302
6319
SEQ ID
AGGTGAGCTGCCCAGATG
1.63

1658
1658

3286

SEQ ID
COMP ID
GCCATCTGGGCAGCTCAC
1118
1135
6304
6321
SEQ ID
GTGAGCTGCCCAGATGGC
1.04

1659
1659

3287

SEQ ID
COMP ID
TAGCCATCTGGGCAGCTC
1120
1137
6306
6323
SEQ ID
GAGCTGCCCAGATGGCTA
1.24

1660
1660

3288

SEQ ID
COMP ID
TATAGCCATCTGGGCAGC
1122
1139
6308
6325
SEQ ID
GCTGCCCAGATGGCTATA
1.19

1661
1661

3289

SEQ ID
COMP ID
GGTATAGCCATCTGGGCA
1124
1141
6310
6327
SEQ ID
TGCCCAGATGGCTATACC
no data

1662
1662

3290

SEQ ID
COMP ID
CAGGTATAGCCATCTGGG
1126
1143
6312
6329
SEQ ID
CCCAGATGGCTATACCTG
1.15

1663
1663

3291

SEQ ID
COMP ID
AGCAGGTATAGCCATCTG
1128
1145
6314
6331
SEQ ID
CAGATGGCTATACCTGCT
1.34

1664
1664

3292

SEQ ID
COMP ID
GCAGCAGGTATAGCCATC
1130
1147
6316
6333
SEQ ID
GATGGCTATACCTGCTGC
1.15

1665
1665

3293

SEQ ID
COMP ID
CGGCAGCAGGTATAGCCA
1132
1149
6318
6335
SEQ ID
TGGCTATACCTGCTGCCG
1.35

1666
1666

3294

SEQ ID
COMP ID
GACGGCAGCAGGTATAGC
1134
1151
6320
6337
SEQ ID
GCTATACCTGCTGCCGTC
1.69

1667
1667

3295

SEQ ID
COMP ID
TAGACGGCAGCAGGTATA
1136
1153
6322
6339
SEQ ID
TATACCTGCTGCCGTCTA
1.38

1668
1668

3296

SEQ ID
COMP ID
TGTAGACGGCAGCAGGTA
1138
1155
6324
6341
SEQ ID
TACCTGCTGCCGTCTACA
1.68

1669
1669

3297

SEQ ID
COMP ID
ACTGTAGACGGCAGCAGG
1140
1157
6326
6343
SEQ ID
CCTGCTGCCGTCTACAGT
1.34

1670
1670

3298

SEQ ID
COMP ID
CGACTGTAGACGGCAGCA
1142
1159
6328
6345
SEQ ID
TGCTGCCGTCTACAGTCG
1.4

1671
1671

3299

SEQ ID
COMP ID
CCCGACTGTAGACGGCAG
1144
1161
6330
6347
SEQ ID
CTGCCGTCTACAGTCGGG
1.22

1672
1672

3300

SEQ ID
COMP ID
CCCCCGACTGTAGACGGC
1146
1163
6332
6349
SEQ ID
GCCGTCTACAGTCGGGGG
1.24

1673
1673

3301

SEQ ID
COMP ID
GGCCCCCGACTGTAGACG
1148
1165
6334
6351
SEQ ID
CGTCTACAGTCGGGGGCC
1.28

1674
1674

3302

SEQ ID
COMP ID
CAGGCCCCCGACTGTAGA
1150
1167
6336
6353
SEQ ID
TCTACAGTCGGGGGCCTG
1.47

1675
1675

3303

SEQ ID
COMP ID
CCCAGGCCCCCGACTGTA
1152
1169
6338
6355
SEQ ID
TACAGTCGGGGGCCTGGG
1.16

1676
1676

3304

SEQ ID
COMP ID
GCCCCAGGCCCCCGACTG
1154
1171
6340
6357
SEQ ID
CAGTCGGGGGCCTGGGGC
1.6

1677
1677

3305

SEQ ID
COMP ID
CAGCCCCAGGCCCCCGAC
1156
1173
6342
6359
SEQ ID
GTCGGGGGCCTGGGGCTG
1.19

1678
1678

3306

SEQ ID
COMP ID
AGCAGCCCCAGGCCCCCG
1158
1175
6344
6361
SEQ ID
CGGGGGCCTGGGGCTGCT
1.54

1679
1679

3307

SEQ ID
COMP ID
GCAGCAGCCCCAGGCCCC
1160
1177
6346
6363
SEQ ID
GGGGCCTGGGGCTGCTGC
1.27

1680
1680

3308

SEQ ID
COMP ID
GGGCAGCAGCCCCAGGCC
1162
1179
6348
6365
SEQ ID
GGCCTGGGGCTGCTGCCC
1.55

1681
1681

3309

SEQ ID
COMP ID
AAGGGCAGCAGCCCCAGG
1164
1181
6350
6367
SEQ ID
CCTGGGGCTGCTGCCCTT
1.04

1682
1682

3310

SEQ ID
COMP ID
AAAAGGGCAGCAGCCCCA
1166
1183
6352
6369
SEQ ID
TGGGGCTGCTGCCCTTTT
1.3

1683
1683

3311

SEQ ID
COMP ID
GTAAAAGGGCAGCAGCCC
1168
1185
6354
6371
SEQ ID
GGGCTGCTGCCCTTTTAC
1.6

1684
1684

3312

SEQ ID
COMP ID
GGGTAAAAGGGCAGCAGC
1170
1187
6356
6373
SEQ ID
GCTGCTGCCCTTTTACCC
2.89

1685
1685

3313

SEQ ID
COMP ID
CTGGGTAAAAGGGCAGCA
1172
1189
6358
6375
SEQ ID
TGCTGCCCTTTTACCCAG
2.6

1686
1686

3314

SEQ ID
COMP ID
ACCTGGGTAAAAGGGCAG

6360
6377
SEQ ID
CTGCCCTTTTACCCAGGT
1.27

1687
1687

3315

SEQ ID
COMP ID
GTACCTGGGTAAAAGGGC

6362
6379
SEQ ID
GCCCTTTTACCCAGGTAC
1.55

1688
1688

3316

SEQ ID
COMP ID
GGGTACCTGGGTAAAAGG

6364
6381
SEQ ID
CCTTTTACCCAGGTACCC
2.16

1689
1689

3317

SEQ ID
COMP ID
CTGGGTACCTGGGTAAAA

6366
6383
SEQ ID
TTTTACCCAGGTACCCAG
1.55

1690
1690

3318

SEQ ID
COMP ID
CCCTGGGTACCTGGGTAA

6368
6385
SEQ ID
TTACCCAGGTACCCAGGG
no data

1691
1691

3319

SEQ ID
COMP ID
ACCCCTGGGTACCTGGGT

6370
6387
SEQ ID
ACCCAGGTACCCAGGGGT
1.57

1692
1692

3320

SEQ ID
COMP ID
CCACCCCTGGGTACCTGG

6372
6389
SEQ ID
CCAGGTACCCAGGGGTGG
1.09

1693
1693

3321

SEQ ID
COMP ID
CGCCACCCCTGGGTACCT

6374
6391
SEQ ID
AGGTACCCAGGGGTGGCG
1.24

1694
1694

3322

SEQ ID
COMP ID
CCCGCCACCCCTGGGTAC

6376
6393
SEQ ID
GTACCCAGGGGTGGGGG
1.28

1695
1695

3323

SEQ ID
COMP ID
CACCCGCCACCCCTGGGT

6378
6395
SEQ ID
ACCCAGGGGTGGCGGGTG
1.24

1696
1696

3324

SEQ ID
COMP ID
CCCACCCGCCACCCCTGG

6380
6397
SEQ ID
CCAGGGGTGGCGGGTGGG
1.21

1697
1697

3325

SEQ ID
COMP ID
CACCCACCCGCCACCCCT

6382
6399
SEQ ID
AGGGGTGGCGGGTGGGTG
1.13

1698
1698

3326

SEQ ID
COMP ID
CCCACCCACCCGCCACCC

6384
6401
SEQ ID
GGGTGGGGGGTGGGTGGG
1.11

1699
1699

3327

SEQ ID
COMP ID
AGCCCACCCACCCGCCAC

6386
6403
SEQ ID
GTGGCGGGTGGGTGGGCT
0.97

1700
1700

3328

SEQ ID
COMP ID
TCAGCCCACCCACCCGCC

6388
6405
SEQ ID
GGCGGGTGGGTGGGCTGA
1.16

1701
1701

3329

SEQ ID
COMP ID
GCTCAGCCCACCCACCCG

6390
6407
SEQ ID
CGGGTGGGTGGGCTGAGC
0.99

1702
1702

3330

SEQ ID
COMP ID
GTGCTCAGCCCACCCACC

6392
6409
SEQ ID
GGTGGGTGGGCTGAGCAC
1.24

1703
1703

3331

SEQ ID
COMP ID
CTGTGCTCAGCCCACCCA

6394
6411
SEQ ID
TGGGTGGGCTGAGCACAG
1.54

1704
1704

3332

SEQ ID
COMP ID
CACTGTGCTCAGCCCACC

6396
6413
SEQ ID
GGTGGGCTGAGCACAGTG
1.04

1705
1705

3333

SEQ ID
COMP ID
CACACTGTGCTCAGCCCA

6398
6415
SEQ ID
TGGGCTGAGCACAGTGTG
1.37

1706
1706

3334

SEQ ID
COMP ID
GCCACACTGTGCTCAGCC

6400
6417
SEQ ID
GGCTGAGCACAGTGTGGC
1.7

1707
1707

3335

SEQ ID
COMP ID
CTGCCACACTGTGCTCAG

6402
6419
SEQ ID
CTGAGCACAGTGTGGCAG
1.54

1708
1708

3336

SEQ ID
COMP ID
GCCTGCCACACTGTGCTC

6404
6421
SEQ ID
GAGCACAGTGTGGCAGGC
1.66

1709
1709

3337

SEQ ID
COMP ID
CTGCCTGCCACACTGTGC

6406
6423
SEQ ID
GCACAGTGTGGCAGGCAG
1.77

1710
1710

3338

SEQ ID
COMP ID
GGCTGCCTGCCACACTGT

6408
6425
SEQ ID
ACAGTGTGGCAGGCAGCC
1.54

1711
1711

3339

SEQ ID
COMP ID
GGGCCCGGCTGCCTGCCA

6414
6431
SEQ ID
TGGCAGGCAGCCGGGCCC
1.76

1712
1712

3340

SEQ ID
COMP ID
TGGGGCCCGGCTGCCTGC

6416
6433
SEQ ID
GCAGGCAGCCGGGCCCCA
no data

1713
1713

3341

SEQ ID
COMP ID
ACTGGGGCCCGGCTGCCT

6418
6435
SEQ ID
AGGCAGCCGGGCCCCAGT
2.55

1714
1714

3342

SEQ ID
COMP ID
GCACTGGGGCCCGGCTGC

6420
6437
SEQ ID
GCAGCCGGGCCCCAGTGC
2.04

1715
1715

3343

SEQ ID
COMP ID
GGGCACTGGGGCCCGGCT

6422
6439
SEQ ID
AGCCGGGCCCCAGTGCCC
1.25

1716
1716

3344

SEQ ID
COMP ID
GTGGGCACTGGGGCCCGG

6424
6441
SEQ ID
CCGGGCCCCAGTGCCCAC
1.68

1717
1717

3345

SEQ ID
COMP ID
AGGTGGGCACTGGGGCCC

6426
6443
SEQ ID
GGGCCCCAGTGCCCACCT
1.58

1718
1718

3346

SEQ ID
COMP ID
GCAGGTGGGCACTGGGGC

6428
6445
SEQ ID
GCCCCAGTGCCCACCTGC
3.33

1719
1719

3347

SEQ ID
COMP ID
GGGCAGGTGGGCACTGGG

6430
6447
SEQ ID
CCCAGTGCCCACCTGCCC
2.92

1720
1720

3348

SEQ ID
COMP ID
AAGGGCAGGTGGGCACTG

6432
6449
SEQ ID
CAGTGCCCACCTGCCCTT
2.69

1721
1721

3349

SEQ ID
COMP ID
AGAAGGGCAGGTGGGCAC

6434
6451
SEQ ID
GTGCCCACCTGCCCTTCT
3.06

1722
1722

3350

SEQ ID
COMP ID
GAAGAAGGGCAGGTGGGC

6436
6453
SEQ ID
GCCCACCTGCCCTTCTTC
2.88

1723
1723

3351

SEQ ID
COMP ID
ATGAAGAAGGGCAGGTGG

6438
6455
SEQ ID
CCACCTGCCCTTCTTCAT
3.3

1724
1724

3352

SEQ ID
COMP ID
AGATGAAGAAGGGCAGGT

6440
6457
SEQ ID
ACCTGCCCTTCTTCATCT
2.64

1725
1725

3353

SEQ ID
COMP ID
GCAGATGAAGAAGGGCAG

6442
6459
SEQ ID
CTGCCCTTCTTCATCTGC
1.71

1726
1726

3354

SEQ ID
COMP ID
GGGCAGATGAAGAAGGGC

6444
6461
SEQ ID
GCCCTTCTTCATCTGCCC
2.62

1727
1727

3355

SEQ ID
COMP ID
TAGGGCAGATGAAGAAGG

6446
6463
SEQ ID
CCTTCTTCATCTGCCCTA
1.99

1728
1728

3356

SEQ ID
COMP ID
GTCCTCACAGCACACAGC
1190
1207
6465
6482
SEQ ID
GCTGTGTGCTGTGAGGAC
1.2

1729
1729

3357

SEQ ID
COMP ID
TGGTCCTCACAGCACACA
1192
1209
6467
6484
SEQ ID
TGTGTGCTGTGAGGACCA
1.44

1730
1730

3358

SEQ ID
COMP ID
TGTGGTCCTCACAGCACA
1194
1211
6469
6486
SEQ ID
TGTGCTGTGAGGACCACA
1.75

1731
1731

3359

SEQ ID
COMP ID
TATGTGGTCCTCACAGCA
1196
1213
6471
6488
SEQ ID
TGCTGTGAGGACCACATA
1.61

1732
1732

3360

SEQ ID
COMP ID
TGTATGTGGTCCTCACAG
1198
1215
6473
6490
SEQ ID
CTGTGAGGACCACATACA
2.24

1733
1733

3361

SEQ ID
COMP ID
AGTGTATGTGGTCCTCAC
1200
1217
6475
6492
SEQ ID
GTGAGGACCACATACACT
2.42

1734
1734

3362

SEQ ID
COMP ID
GCAGTGTATGTGGTCCTC
1202
1219
6477
6494
SEQ ID
GAGGACCACATACACTGC
2.48

1735
1735

3363

SEQ ID
COMP ID
CAGCAGTGTATGTGGTCC
1204
1221
6479
6496
SEQ ID
GGACCACATACACTGCTG
2.26

1736
1736

3364

SEQ ID
COMP ID
GACAGCAGTGTATGTGGT
1206
1223
6481
6498
SEQ ID
ACCACATACACTGCTGTC
1.63

1737
1737

3365

SEQ ID
COMP ID
GGGACAGCAGTGTATGTG
1208
1225
6483
6500
SEQ ID
CACATACACTGCTGTCCC
2.73

1738
1738

3366

SEQ ID
COMP ID
GCGGGACAGCAGTGTATG
1210
1227
6485
6502
SEQ ID
CATACACTGCTGTCCCGC
1.46

1739
1739

3367

SEQ ID
COMP ID
CCGCGGGACAGCAGTGTA
1212
1229
6487
6504
SEQ ID
TACACTGCTGTCCCGCGG
1.42

1740
1740

3368

SEQ ID
COMP ID
CCCCGCGGGACAGCAGTG
1214
1231
6489
6506
SEQ ID
CACTGCTGTCCCGCGGGG
1.69

1741
1741

3369

SEQ ID
COMP ID
AACCCCGCGGGACAGCAG
1216
1233
6491
6508
SEQ ID
CTGCTGTCCCGCGGGGTT
1.91

1742
1742

3370

SEQ ID
COMP ID
TAAACCCCGCGGGACAGC
1218
1235
6493
6510
SEQ ID
GCTGTCCCGCGGGGTTTA
1.31

1743
1743

3371

SEQ ID
COMP ID
CGTAAACCCCGCGGGACA
1220
1237
6495
6512
SEQ ID
TGTCCCGCGGGGTTTACG
no data

1744
1744

3372

SEQ ID
COMP ID
CACGTAAACCCCGCGGGA
1222
1239
6497
6514
SEQ ID
TCCCGCGGGGTTTACGTG
no data

1745
1745

3373

SEQ ID
COMP ID
CACACGTAAACCCCGCGG
1224
1241
6499
6516
SEQ ID
CCGCGGGGTTTACGTGTG
no data

1746
1746

3374

SEQ ID
COMP ID
GTCACACGTAAACCCCGC
1226
1243
6501
6518
SEQ ID
GCGGGGTTTACGTGTGAC
no data

1747
1747

3375

SEQ ID
COMP ID
GTGTCACACGTAAACCCC
1228
1245
6503
6520
SEQ ID
GGGGTTTACGTGTGACAC
no data

1748
1748

3376

SEQ ID
COMP ID
GCGTGTCACACGTAAACC
1230
1247
6505
6522
SEQ ID
GGTTTACGTGTGACACGC
no data

1749
1749

3377

SEQ ID
COMP ID
CTGCGTGTCACACGTAAA
1232
1249
6507
6524
SEQ ID
TTTACGTGTGACACGCAG
no data

1750
1750

3378

SEQ ID
COMP ID
TTCTGCGTGTCACACGTA
1234
1251
6509
6526
SEQ ID
TACGTGTGACACGCAGAA
no data

1751
1751

3379

SEQ ID
COMP ID
CCTTCTGCGTGTCACACG
1236
1253
6511
6528
SEQ ID
CGTGTGACACGCAGAAGG
no data

1752
1752

3380

SEQ ID
COMP ID
ACCCTTCTGCGTGTCACA
1238
1255
6513
6530
SEQ ID
TGTGACACGCAGAAGGGT
no data

1753
1753

3381

SEQ ID
COMP ID
GTACCCTTCTGCGTGTCA
1240
1257
6515
6532
SEQ ID
TGACACGCAGAAGGGTAC
no data

1754
1754

3382

SEQ ID
COMP ID
AGGTACCCTTCTGCGTGT
1242
1259
6517
6534
SEQ ID
ACACGCAGAAGGGTACCT
no data

1755
1755

3383

SEQ ID
COMP ID
ACAGGTACCCTTCTGCGT
1244
1261
6519
6536
SEQ ID
ACGCAGAAGGGTACCTGT
no data

1756
1756

3384

SEQ ID
COMP ID
TCACAGGTACCCTTCTGC
1246
1263
6521
6538
SEQ ID
GCAGAAGGGTACCTGTGA
no data

1757
1757

3385

SEQ ID
COMP ID
GTTCACAGGTACCCTTCT
1248
1265
6523
6540
SEQ ID
AGAAGGGTACCTGTGAAC
no data

1758
1758

3386

SEQ ID
COMP ID
CTGTTCACAGGTACCCTT
1250
1267
6525
6542
SEQ ID
AAGGGTACCTGTGAACAG
no data

1759
1759

3387

SEQ ID
COMP ID
CCCTGTTCACAGGTACCC
1252
1269
6527
6544
SEQ ID
GGGTACCTGTGAACAGGG
no data

1760
1760

3388

SEQ ID
COMP ID
GCCCCTGTTCACAGGTAC
1254
1271
6529
6546
SEQ ID
GTACCTGTGAACAGGGGC
no data

1761
1761

3389

SEQ ID
COMP ID
GGGCCCCTGTTCACAGGT
1256
1273
6531
6548
SEQ ID
ACCTGTGAACAGGGGCCC
1.64

1762
1762

3390

SEQ ID
COMP ID
TGGGGCCCCTGTTCACAG
1258
1275
6533
6550
SEQ ID
CTGTGAACAGGGGCCCCA
1.48

1763
1763

3391

SEQ ID
COMP ID
GGTGGGGCCCCTGTTCAC
1260
1277
6535
6552
SEQ ID
GTGAACAGGGGCCCCACC
1.51

1764
1764

3392

SEQ ID
COMP ID
CTGGTGGGGCCCCTGTTC
1262
1279
6537
6554
SEQ ID
GAACAGGGGCCCCACCAG
1.9

1765
1765

3393

SEQ ID
COMP ID
ACCTGGTGGGGCCCCTGT
1264
1281
6539
6556
SEQ ID
ACAGGGGCCCCACCAGGT
2.02

1766
1766

3394

SEQ ID
COMP ID
GCACCTGGTGGGGCCCCT
1266
1283
6541
6558
SEQ ID
AGGGGCCCCACCAGGTGC
2.13

1767
1767

3395

SEQ ID
COMP ID
GGGCACCTGGTGGGGCCC
1268
1285
6543
6560
SEQ ID
GGGCCCCACCAGGTGCCC
1.76

1768
1768

3396

SEQ ID
COMP ID
CAGGGCACCTGGTGGGGC
1270
1287
6545
6562
SEQ ID
GCCCCACCAGGTGCCCTG
1.91

1769
1769

3397

SEQ ID
COMP ID
TCCAGGGCACCTGGTGGG
1272
1289
6547
6564
SEQ ID
CCCACCAGGTGCCCTGGA
1.51

1770
1770

3398

SEQ ID
COMP ID
CATCCAGGGCACCTGGTG
1274
1291
6549
6566
SEQ ID
CACCAGGTGCCCTGGATG
1.55

1771
1771

3399

SEQ ID
COMP ID
TCCATCCAGGGCACCTGG
1276
1293
6551
6568
SEQ ID
CCAGGTGCCCTGGATGGA
1.34

1772
1772

3400

SEQ ID
COMP ID
TCTCCATCCAGGGCACCT
1278
1295
6553
6570
SEQ ID
AGGTGCCCTGGATGGAGA
1.65

1773
1773

3401

SEQ ID
COMP ID
CTTCTCCATCCAGGGCAC
1280
1297
6555
6572
SEQ ID
GTGCCCTGGATGGAGAAG
1.29

1774
1774

3402

SEQ ID
COMP ID
GCCTTCTCCATCCAGGGC
1282
1299
6557
6574
SEQ ID
GCCCTGGATGGAGAAGGC
1.6

1775
1775

3403

SEQ ID
COMP ID
GGGCCTTCTCCATCCAGG
1284
1301
6559
6576
SEQ ID
CCTGGATGGAGAAGGCCC
1.54

1776
1776

3404

SEQ ID
COMP ID
TGGGGCCTTCTCCATCCA
1286
1303
6561
6578
SEQ ID
TGGATGGAGAAGGCCCCA
1.32

1777
1777

3405

SEQ ID
COMP ID
GCTGGGGCCTTCTCCATC
1288
1305
6563
6580
SEQ ID
GATGGAGAAGGCCCCAGC
1.29

1778
1778

3406

SEQ ID
COMP ID
GAGCTGGGGCCTTCTCCA
1290
1307
6565
6582
SEQ ID
TGGAGAAGGCCCCAGCTC
1.68

1779
1779

3407

SEQ ID
COMP ID
GTGAGCTGGGGCCTTCTC
1292
1309
6567
6584
SEQ ID
GAGAAGGCCCCAGCTCAC
2.12

1780
1780

3408

SEQ ID
COMP ID
AGGTGAGCTGGGGCCTTC
1294
1311
6569
6586
SEQ ID
GAAGGCCCCAGCTCACCT
2.3

1781
1781

3409

SEQ ID
COMP ID
TGAGGTGAGCTGGGGCCT
1296
1313
6571
6588
SEQ ID
AGGCCCCAGCTCACCTCA
1.88

1782
1782

3410

SEQ ID
COMP ID
GCTGAGGTGAGCTGGGGC
1298
1315
6573
6590
SEQ ID
GCCCCAGCTCACCTCAGC
2.3

1783
1783

3411

SEQ ID
COMP ID
AGGCTGAGGTGAGCTGGG
1300
1317
6575
6592
SEQ ID
CCCAGCTCACCTCAGCCT
2.25

1784
1784

3412

SEQ ID
COMP ID
GCAGGCTGAGGTGAGCTG
1302
1319
6577
6594
SEQ ID
CAGCTCACCTCAGCCTGC
1.51

1785
1785

3413

SEQ ID
COMP ID
TGGCAGGCTGAGGTGAGC
1304
1321
6579
6596
SEQ ID
GCTCACCTCAGCCTGCCA
1.59

1786
1786

3414

SEQ ID
COMP ID
TCTGGCAGGCTGAGGTGA
1306
1323
6581
6598
SEQ ID
TCACCTCAGCCTGCCAGA
1.82

1787
1787

3415

SEQ ID
COMP ID
GGTCTGGCAGGCTGAGGT
1308
1325
6583
6600
SEQ ID
ACCTCAGCCTGCCAGACC
1.48

1788
1788

3416

SEQ ID
COMP ID
TGGGTCTGGCAGGCTGAG
1310
1327
6585
6602
SEQ ID
CTCAGCCTGCCAGACCCA
1.69

1789
1789

3417

SEQ ID
COMP ID
TGTGGGTCTGGCAGGCTG
1312
1329
6587
6604
SEQ ID
CAGCCTGCCAGACCCACA
1.49

1790
1790

3418

SEQ ID
COMP ID
CTTGTGGGTCTGGCAGGC
1314
1331
6589
6606
SEQ ID
GCCTGCCAGACCCACAAG
1.6

1791
1791

3419

SEQ ID
COMP ID
GGCTTGTGGGTCTGGCAG
1316
1333
6591
6608
SEQ ID
CTGCCAGACCCACAAGCC
1.76

1792
1792

3420

SEQ ID
COMP ID
AAGGCTTGTGGGTCTGGC
1318
1335
6593
6610
SEQ ID
GCCAGACCCACAAGCCTT
1.3

1793
1793

3421

SEQ ID
COMP ID
TCAAGGCTTGTGGGTCTG
1320
1337
6595
6612
SEQ ID
CAGACCCACAAGCCTTGA
1.81

1794
1794

3422

SEQ ID
COMP ID
CTTCAAGGCTTGTGGGTC
1322
1339
6597
6614
SEQ ID
GACCCACAAGCCTTGAAG
1.75

1795
1795

3423

SEQ ID
COMP ID
CTCTTCAAGGCTTGTGGG
1324
1341
6599
6616
SEQ ID
CCCACAAGCCTTGAAGAG
1.5

1796
1796

3424

SEQ ID
COMP ID
CTCTCTTCAAGGCTTGTG
1326
1343
6601
6618
SEQ ID
CACAAGCCTTGAAGAGAG
1.4

1797
1797

3425

SEQ ID
COMP ID
ATCTCTCTTCAAGGCTTG
1328
1345
6603
6620
SEQ ID
CAAGCCTTGAAGAGAGAT
1.39

1798
1798

3426

SEQ ID
COMP ID
ACATCTCTCTTCAAGGCT
1330
1347
6605
6622
SEQ ID
AGCCTTGAAGAGAGATGT
1.15

1799
1799

3427

SEQ ID
COMP ID
GGACATCTCTCTTCAAGG
1332
1349
6607
6624
SEQ ID
CCTTGAAGAGAGATGTCC
1.66

1800
1800

3428

SEQ ID
COMP ID
GGGGACATCTCTCTTCAA
1334
1351
6609
6626
SEQ ID
TTGAAGAGAGATGTCCCC
1.66

1801
1801

3429

SEQ ID
COMP ID
CAGGGGACATCTCTCTTC
1336
1353
6611
6628
SEQ ID
GAAGAGAGATGTCCCCTG
1.76

1802
1802

3430

SEQ ID
COMP ID
CACAGGGGACATCTCTCT
1338
1355
6613
6630
SEQ ID
AGAGAGATGTCCCCTGTG
1.48

1803
1803

3431

SEQ ID
COMP ID
ATCACAGGGGACATCTCT
1340
1357
6615
6632
SEQ ID
AGAGATGTCCCCTGTGAT
2.37

1804
1804

3432

SEQ ID
COMP ID
TTATCACAGGGGACATCT
1342
1359
6617
6634
SEQ ID
AGATGTCCCCTGTGATAA
2.41

1805
1805

3433

SEQ ID
COMP ID
CATTATCACAGGGGACAT
1344
1361
6619
6636
SEQ ID
ATGTCCCCTGTGATAATG
1.94

1806
1806

3434

SEQ ID
COMP ID
GACATTATCACAGGGGAC
1346
1363
6621
6638
SEQ ID
GTCCCCTGTGATAATGTC
2.18

1807
1807

3435

SEQ ID
COMP ID
CTGACATTATCACAGGGG
1348
1365
6623
6640
SEQ ID
CCCCTGTGATAATGTCAG
2.28

1808
1808

3436

SEQ ID
COMP ID
TGCTGACATTATCACAGG
1350
1367
6625
6642
SEQ ID
CCTGTGATAATGTCAGCA
1.89

1809
1809

3437

SEQ ID
COMP ID
GCTGCTGACATTATCACA
1352
1369
6627
6644
SEQ ID
TGTGATAATGTCAGCAGC
1.14

1810
1810

3438

SEQ ID
COMP ID
CAGCTGCTGACATTATCA
1354
1371
6629
6646
SEQ ID
TGATAATGTCAGCAGCTG
1.63

1811
1811

3439

SEQ ID
COMP ID
GACAGCTGCTGACATTAT
1356
1373
6631
6648
SEQ ID
ATAATGTCAGCAGCTGTC
1.59

1812
1812

3440

SEQ ID
COMP ID
GGGACAGCTGCTGACATT
1358
1375
6633
6650
SEQ ID
AATGTCAGCAGCTGTCCC
2.5

1813
1813

3441

SEQ ID
COMP ID
GAGGGACAGCTGCTGACA
1360
1377
6635
6652
SEQ ID
TGTCAGCAGCTGTCCCTC
2.06

1814
1814

3442

SEQ ID
COMP ID
AGGAGGGACAGCTGCTGA
1362
1379
6637
6654
SEQ ID
TCAGCAGCTGTCCCTCCT
2.87

1815
1815

3443

SEQ ID
COMP ID
GGAGGAGGGACAGCTGCT
1364
1381
6639
6656
SEQ ID
AGCAGCTGTCCCTCCTCC
1.89

1816
1816

3444

SEQ ID
COMP ID
TCGGAGGAGGGACAGCTG
1366
1383
6641
6658
SEQ ID
CAGCTGTCCCTCCTCCGA
1.93

1817
1817

3445

SEQ ID
COMP ID
TATCGGAGGAGGGACAGC
1368
1385
6643
6660
SEQ ID
GCTGTCCCTCCTCCGATA
2.12

1818
1818

3446

SEQ ID
COMP ID
GGTATCGGAGGAGGGACA
1370
1387
6645
6662
SEQ ID
TGTCCCTCCTCCGATACC
2.22

1819
1819

3447

SEQ ID
COMP ID
CAGGTATCGGAGGAGGGA
1372
1389
6647
6664
SEQ ID
TCCCTCCTCCGATACCTG
2.55

1820
1820

3448

SEQ ID
COMP ID
AGCAGGTATCGGAGGAGG
1374
1391
6649
6666
SEQ ID
CCTCCTCCGATACCTGCT
2.39

1821
1821

3449

SEQ ID
COMP ID
GCAGCAGGTATCGGAGGA
1376
1393
6651
6668
SEQ ID
TCCTCCGATACCTGCTGC
2.06

1822
1822

3450

SEQ ID
COMP ID
TGGCAGCAGGTATCGGAG
1378
1395
6653
6670
SEQ ID
CTCCGATACCTGCTGCCA
1.88

1823
1823

3451

SEQ ID
COMP ID
GTTGGCAGCAGGTATCGG
1380
1397
6655
6672
SEQ ID
CCGATACCTGCTGCCAAC
1.92

1824
1824

3452

SEQ ID
COMP ID
GAGTTGGCAGCAGGTATC
1382
1399
6657
6674
SEQ ID
GATACCTGCTGCCAACTC
1.48

1825
1825

3453

SEQ ID
COMP ID
GTGAGTTGGCAGCAGGTA
1384
1401
6659
6676
SEQ ID
TACCTGCTGCCAACTCAC
1.14

1826
1826

3454

SEQ ID
COMP ID
ACGTGAGTTGGCAGCAGG
1386
1403
6661
6678
SEQ ID
CCTGCTGCCAACTCACGT
no data

1827
1827

3455

SEQ ID
COMP ID
AGACGTGAGTTGGCAGCA
1388
1405
6663
6680
SEQ ID
TGCTGCCAACTCACGTCT
no data

1828
1828

3456

SEQ ID
COMP ID
CCAGACGTGAGTTGGCAG
1390
1407
6665
6682
SEQ ID
CTGCCAACTCACGTCTGG
no data

1829
1829

3457

SEQ ID
COMP ID
CCCCAGACGTGAGTTGGC
1392
1409
6667
6684
SEQ ID
GCCAACTCACGTCTGGGG
no data

1830
1830

3458

SEQ ID
COMP ID
CTCCCCAGACGTGAGTTG
1394
1411
6669
6686
SEQ ID
CAACTCACGTCTGGGGAG
no data

1831
1831

3459

SEQ ID
COMP ID
CACTCCCCAGACGTGAGT
1396
1413
6671
6688
SEQ ID
ACTCACGTCTGGGGAGTG
1.67

1832
1832

3460

SEQ ID
COMP ID
CCCACTCCCCAGACGTGA
1398
1415
6673
6690
SEQ ID
TCACGTCTGGGGAGTGGG
1.7

1833
1833

3461

SEQ ID
COMP ID
GCCCCACTCCCCAGACGT
1400
1417
6675
6692
SEQ ID
ACGTCTGGGGAGTGGGGC
no data

1834
1834

3462

SEQ ID
COMP ID
CAGCCCCACTCCCCAGAC
1402
1419
6677
6694
SEQ ID
GTCTGGGGAGTGGGGCTG
no data

1835
1835

3463

SEQ ID
COMP ID
AGCAGCCCCACTCCCCAG
1404
1421
6679
6696
SEQ ID
CTGGGGAGTGGGGCTGCT
1.34

1836
1836

3464

SEQ ID
COMP ID
ACAGCAGCCCCACTCCCC
1406
1423
6681
6698
SEQ ID
GGGGAGTGGGGCTGCTGT
1.38

1837
1837

3465

SEQ ID
COMP ID
GGACAGCAGCCCCACTCC
1408
1425
6683
6700
SEQ ID
GGAGTGGGGCTGCTGTCC
1.63

1838
1838

3466

SEQ ID
COMP ID
TTGGACAGCAGCCCCACT
1410
1427
6685
6702
SEQ ID
AGTGGGGCTGCTGTCCAA
1.72

1839
1839

3467

SEQ ID
COMP ID
GATTGGACAGCAGCCCCA
1412
1429
6687
6704
SEQ ID
TGGGGCTGCTGTCCAATC
1.58

1840
1840

3468

SEQ ID
COMP ID
GGGATTGGACAGCAGCCC
1414
1431
6689
6706
SEQ ID
GGGCTGCTGTCCAATCCC
no data

1841
1841

3469

SEQ ID
COMP ID
CTGGGATTGGACAGCAGC
1416
1433
6691
6708
SEQ ID
GCTGCTGTCCAATCCCAG
no data

1842
1842

3470

SEQ ID
COMP ID
CTCTGGGATTGGACAGCA
1418
1435
6693
6710
SEQ ID
TGCTGTCCAATCCCAGAG
no data

1843
1843

3471

SEQ ID
COMP ID
GCTGTCCCCTCCCATATA

6712
6729
SEQ ID
TATATGGGAGGGGACAGC
no data

1844
1844

3472

SEQ ID
COMP ID
ATGCTGTCCCCTCCCATA

6714
6731
SEQ ID
TATGGGAGGGGACAGCAT
no data

1845
1845

3473

SEQ ID
COMP ID
AGATGCTGTCCCCTCCCA

6716
6733
SEQ ID
TGGGAGGGGACAGCATCT
no data

1846
1846

3474

SEQ ID
COMP ID
CAAGATGCTGTCCCCTCC

6718
6735
SEQ ID
GGAGGGGACAGCATCTTG
no data

1847
1847

3475

SEQ ID
COMP ID
GCCAAGATGCTGTCCCCT

6720
6737
SEQ ID
AGGGGACAGCATCTTGGC
no data

1848
1848

3476

SEQ ID
COMP ID
AGGCCAAGATGCTGTCCC

6722
6739
SEQ ID
GGGACAGCATCTTGGCCT
no data

1849
1849

3477

SEQ ID
COMP ID
CCAGGCCAAGATGCTGTC

6724
6741
SEQ ID
GACAGCATCTTGGCCTGG
no data

1850
1850

3478

SEQ ID
COMP ID
GCCCAGGCCAAGATGCTG

6726
6743
SEQ ID
CAGCATCTTGGCCTGGGC
no data

1851
1851

3479

SEQ ID
COMP ID
CTGCCCAGGCCAAGATGC

6728
6745
SEQ ID
GCATCTTGGCCTGGGCAG
no data

1852
1852

3480

SEQ ID
COMP ID
ACCTGCCCAGGCCAAGAT

6730
6747
SEQ ID
ATCTTGGCCTGGGCAGGT
no data

1853
1853

3481

SEQ ID
COMP ID
CCACCTGCCCAGGCCAAG

6732
6749
SEQ ID
CTTGGCCTGGGCAGGTGG
no data

1854
1854

3482

SEQ ID
COMP ID
ACCCACCTGCCCAGGCCA

6734
6751
SEQ ID
TGGCCTGGGCAGGTGGGT
no data

1855
1855

3483

SEQ ID
COMP ID
CCACCCACCTGCCCAGGC

6736
6753
SEQ ID
GCCTGGGCAGGTGGGTGG
no data

1856
1856

3484

SEQ ID
COMP ID
GGCCACCCACCTGCCCAG

6738
6755
SEQ ID
CTGGGCAGGTGGGTGGCC
no data

1857
1857

3485

SEQ ID
COMP ID
TTGGCCACCCACCTGCCC

6740
6757
SEQ ID
GGGCAGGTGGGTGGCCAA
1.32

1858
1858

3486

SEQ ID
COMP ID
GCTTGGCCACCCACCTGC

6742
6759
SEQ ID
GCAGGTGGGTGGCCAAGC
1.18

1859
1859

3487

SEQ ID
COMP ID
GAGCTTGGCCACCCACCT

6744
6761
SEQ ID
AGGTGGGTGGCCAAGCTC
1.25

1860
1860

3488

SEQ ID
COMP ID
AGCCACTATGTGGGGCGC

6880
6897
SEQ ID
GCGCCCCACATAGTGGCT
1.14

1861
1861

3489

SEQ ID
COMP ID
GTAGCCACTATGTGGGGC

6882
6899
SEQ ID
GCCCCACATAGTGGCTAC
2.07

1862
1862

3490

SEQ ID
COMP ID
AGGTAGCCACTATGTGGG

6884
6901
SEQ ID
CCCACATAGTGGCTACCT
1.38

1863
1863

3491

SEQ ID
COMP ID
GTAGGTAGCCACTATGTG

6886
6903
SEQ ID
CACATAGTGGCTACCTAC
no data

1864
1864

3492

SEQ ID
COMP ID
TTGTAGGTAGCCACTATG

6888
6905
SEQ ID
CATAGTGGCTACCTACAA
1.38

1865
1865

3493

SEQ ID
COMP ID
CGTTGTAGGTAGCCACTA

6890
6907
SEQ ID
TAGTGGCTACCTACAACG
1.72

1866
1866

3494

SEQ ID
COMP ID
GGCGTTGTAGGTAGCCAC

6892
6909
SEQ ID
GTGGCTACCTACAACGCC
no data

1867
1867

3495

SEQ ID
COMP ID
AGGGCGTTGTAGGTAGCC

6894
6911
SEQ ID
GGCTACCTACAACGCCCT
1.79

1868
1868

3496

SEQ ID
COMP ID
AAAGGGCGTTGTAGGTAG

6896
6913
SEQ ID
CTACCTACAACGCCCTTT
1.45

1869
1869

3497

SEQ ID
COMP ID
GGAAAGGGCGTTGTAGGT

6898
6915
SEQ ID
ACCTACAACGCCCTTTCC
no data

1870
1870

3498

SEQ ID
COMP ID
CAGGAAAGGGCGTTGTAG

6900
6917
SEQ ID
CTACAACGCCCTTTCCTG
no data

1871
1871

3499

SEQ ID
COMP ID
GGCAGGAAAGGGCGTTGT

6902
6919
SEQ ID
ACAACGCCCTTTCCTGCC
no data

1872
1872

3500

SEQ ID
COMP ID
TGGGCAGGAAAGGGCGTT

6904
6921
SEQ ID
AACGCCCTTTCCTGCCCA
1.9

1873
1873

3501

SEQ ID
COMP ID
GGTGGGCAGGAAAGGGCG

6906
6923
SEQ ID
CGCCCTTTCCTGCCCACC
no data

1874
1874

3502

SEQ ID
COMP ID
GGGGTGGGCAGGAAAGGG

6908
6925
SEQ ID
CCCTTTCCTGCCCACCCC
no data

1875
1875

3503

SEQ ID
COMP ID
GGGGGGTGGGCAGGAAAG

6910
6927
SEQ ID
CTTTCCTGCCCACCCCCC
no data

1876
1876

3504

SEQ ID
COMP ID
CTGGGGGGTGGGCAGGAA

6912
6929
SEQ ID
TTCCTGCCCACCCCCCAG
2.53

1877
1877

3505

SEQ ID
COMP ID
GGTCCGAGCAGCAGACAG
1437
1454
6931
6948
SEQ ID
CTGTCTGCTGCTCGGACC
no data

1878
1878

3506

SEQ ID
COMP ID
GTGGTCCGAGCAGCAGAC
1439
1456
6933
6950
SEQ ID
GTCTGCTGCTCGGACCAC
no data

1879
1879

3507

SEQ ID
COMP ID
TGGTGGTCCGAGCAGCAG
1441
1458
6935
6952
SEQ ID
CTGCTGCTCGGACCACCA
1.21

1880
1880

3508

SEQ ID
COMP ID
GCTGGTGGTCCGAGCAGC
1443
1460
6937
6954
SEQ ID
GCTGCTCGGACCACCAGC
no data

1881
1881

3509

SEQ ID
COMP ID
GTGCTGGTGGTCCGAGCA
1445
1462
6939
6956
SEQ ID
TGCTCGGACCACCAGCAC
no data

1882
1882

3510

SEQ ID
COMP ID
CAGTGCTGGTGGTCCGAG
1447
1464
6941
6958
SEQ ID
CTCGGACCACCAGCACTG
1.79

1883
1883

3511

SEQ ID
COMP ID
AGCAGTGCTGGTGGTCCG
1449
1466
6943
6960
SEQ ID
CGGACCACCAGCACTGCT
1.64

1884
1884

3512

SEQ ID
COMP ID
GCAGCAGTGCTGGTGGTC
1451
1468
6945
6962
SEQ ID
GACCACCAGCACTGCTGC
no data

1885
1885

3513

SEQ ID
COMP ID
GGGCAGCAGTGCTGGTGG
1453
1470
6947
6964
SEQ ID
CCACCAGCACTGCTGCCC
no data

1886
1886

3514

SEQ ID
COMP ID
GGGGGCAGCAGTGCTGGT
1455
1472
6949
6966
SEQ ID
ACCAGCACTGCTGCCCCC
no data

1887
1887

3515

SEQ ID
COMP ID
CTGGGGGCAGCAGTGCTG
1457
1474
6951
6968
SEQ ID
CAGCACTGCTGCCCCCAG
2.15

1888
1888

3516

SEQ ID
COMP ID
CCCTGGGGGCAGCAGTGC
1459
1476
6953
6970
SEQ ID
GCACTGCTGCCCCCAGGG
1.71

1889
1889

3517

SEQ ID
COMP ID
AGCCCTGGGGGCAGCAGT
1461
1478
6955
6972
SEQ ID
ACTGCTGCCCCCAGGGCT
1.36

1890
1890

3518

SEQ ID
COMP ID
GTAGCCCTGGGGGCAGCA
1463
1480
6957
6974
SEQ ID
TGCTGCCCCCAGGGCTAC
no data

1891
1891

3519

SEQ ID
COMP ID
GTGTAGCCCTGGGGGCAG
1465
1482
6959
6976
SEQ ID
CTGCCCCCAGGGCTACAC
no data

1892
1892

3520

SEQ ID
COMP ID
ACGTGTAGCCCTGGGGGC
1467
1484
6961
6978
SEQ ID
GCCCCCAGGGCTACACGT
2.09

1893
1893

3521

SEQ ID
COMP ID
ACACGTGTAGCCCTGGGG
1469
1486
6963
6980
SEQ ID
CCCCAGGGCTACACGTGT
1.58

1894
1894

3522

SEQ ID
COMP ID
ACACACGTGTAGCCCTGG
1471
1488
6965
6982
SEQ ID
CCAGGGCTACACGTGTGT
1.42

1895
1895

3523

SEQ ID
COMP ID
CTACACACGTGTAGCCCT
1473
1490
6967
6984
SEQ ID
AGGGCTACACGTGTGTAG
1.39

1896
1896

3524

SEQ ID
COMP ID
AGCTACACACGTGTAGCC
1475
1492
6969
6986
SEQ ID
GGCTACACGTGTGTAGCT
1.23

1897
1897

3525

SEQ ID
COMP ID
TCAGCTACACACGTGTAG
1477
1494
6971
6988
SEQ ID
CTACACGTGTGTAGCTGA
1.21

1898
1898

3526

SEQ ID
COMP ID
CCTCAGCTACACACGTGT
1479
1496
6973
6990
SEQ ID
ACACGTGTGTAGCTGAGG
1.41

1899
1899

3527

SEQ ID
COMP ID
CCCCTCAGCTACACACGT
1481
1498
6975
6992
SEQ ID
ACGTGTGTAGCTGAGGGG
1.17

1900
1900

3528

SEQ ID
COMP ID
TGCCCCTCAGCTACACAC
1483
1500
6977
6994
SEQ ID
GTGTGTAGCTGAGGGGCA
0.85

1901
1901

3529

SEQ ID
COMP ID
ACTGCCCCTCAGCTACAC
1485
1502
6979
6996
SEQ ID
GTGTAGCTGAGGGGCAGT
1.3

1902
1902

3530

SEQ ID
COMP ID
ACACTGCCCCTCAGCTAC
1487
1504
6981
6998
SEQ ID
GTAGCTGAGGGGCAGTGT
1.13

1903
1903

3531

SEQ ID
COMP ID
TGACACTGCCCCTCAGCT
1489
1506
6983
7000
SEQ ID
AGCTGAGGGGCAGTGTCA
1.25

1904
1904

3532

SEQ ID
COMP ID
GCTGACACTGCCCCTCAG
1491
1508
6985
7002
SEQ ID
CTGAGGGGCAGTGTCAGC
no data

1905
1905

3533

SEQ ID
COMP ID
TCGCTGACACTGCCCCTC
1493
1510
6987
7004
SEQ ID
GAGGGGCAGTGTCAGCGA
1.09

1906
1906

3534

SEQ ID
COMP ID
CCTCGCTGACACTGCCCC
1495
1512
6989
7006
SEQ ID
GGGGCAGTGTCAGCGAGG
1.18

1907
1907

3535

SEQ ID
COMP ID
TTCCTCGCTGACACTGCC
1497
1514
6991
7008
SEQ ID
GGCAGTGTCAGCGAGGAA
1.2

1908
1908

3536

SEQ ID
COMP ID
GCTTCCTCGCTGACACTG
1499
1516
6993
7010
SEQ ID
CAGTGTCAGCGAGGAAGC
no data

1909
1909

3537

SEQ ID
COMP ID
TCGCTTCCTCGCTGACAC
1501
1518
6995
7012
SEQ ID
GTGTCAGCGAGGAAGCGA
1.41

1910
1910

3538

SEQ ID
COMP ID
TCTCGCTTCCTCGCTGAC
1503
1520
6997
7014
SEQ ID
GTCAGCGAGGAAGCGAGA
1.26

1911
1911

3539

SEQ ID
COMP ID
GATCTCGCTTCCTCGCTG
1505
1522
6999
7016
SEQ ID
CAGCGAGGAAGCGAGATC
no data

1912
1912

3540

SEQ ID
COMP ID
ACGATCTCGCTTCCTCGC
1507
1524
7001
7018
SEQ ID
GCGAGGAAGCGAGATCGT
1.25

1913
1913

3541

SEQ ID
COMP ID
CCACGATCTCGCTTCCTC
1509
1526
7003
7020
SEQ ID
GAGGAAGCGAGATCGTGG
1.25

1914
1914

3542

SEQ ID
COMP ID
AGCCACGATCTCGCTTCC
1511
1528
7005
7022
SEQ ID
GGAAGCGAGATCGTGGCT
1.31

1915
1915

3543

SEQ ID
COMP ID
CCAGCCACGATCTCGCTT
1513
1530
7007
7024
SEQ ID
AAGCGAGATCGTGGCTGG
1.4

1916
1916

3544

SEQ ID
COMP ID
GTCCAGCCACGATCTCGC
1515
1532
7009
7026
SEQ ID
GCGAGATCGTGGCTGGAC
no data

1917
1917

3545

SEQ ID
COMP ID
CAGTCCAGCCACGATCTC
1517
1534
7011
7028
SEQ ID
GAGATCGTGGCTGGACTG
1.26

1918
1918

3546

SEQ ID
COMP ID
TCCAGTCCAGCCACGATC
1519
1536
7013
7030
SEQ ID
GATCGTGGCTGGACTGGA
0.95

1919
1919

3547

SEQ ID
COMP ID
TCTCCAGTCCAGCCACGA
1521
1538
7015
7032
SEQ ID
TCGTGGCTGGACTGGAGA
1.1

1920
1920

3548

SEQ ID
COMP ID
CTTCTCCAGTCCAGCCAC
1523
1540
7017
7034
SEQ ID
GTGGCTGGACTGGAGAAG
1.3

1921
1921

3549

SEQ ID
COMP ID
ATCTTCTCCAGTCCAGCC
1525
1542
7019
7036
SEQ ID
GGCTGGACTGGAGAAGAT
1.14

1922
1922

3550

SEQ ID
COMP ID
GCATCTTCTCCAGTCCAG
1527
1544
7021
7038
SEQ ID
CTGGACTGGAGAAGATGC
no data

1923
1923

3551

SEQ ID
COMP ID
AGGCATCTTCTCCAGTCC
1529
1546
7023
7040
SEQ ID
GGACTGGAGAAGATGCCT
1.34

1924
1924

3552

SEQ ID
COMP ID
GCAGGCATCTTCTCCAGT
1531
1548
7025
7042
SEQ ID
ACTGGAGAAGATGCCTGC
no data

1925
1925

3553

SEQ ID
COMP ID
GGGCAGGCATCTTCTCCA
1533
1550
7027
7044
SEQ ID
TGGAGAAGATGCCTGCCC
no data

1926
1926

3554

SEQ ID
COMP ID
GCGGGCAGGCATCTTCTC
1535
1552
7029
7046
SEQ ID
GAGAAGATGCCTGCCCGC
no data

1927
1927

3555

SEQ ID
COMP ID
CGGCGGGCAGGCATCTTC
1537
1554
7031
7048
SEQ ID
GAAGATGCCTGCCCGCCG
1.75

1928
1928

3556

SEQ ID
COMP ID
CCCGGCGGGCAGGCATCT
1539
1556
7033
7050
SEQ ID
AGATGCCTGCCCGCCGGG
1.51

1929
1929

3557

SEQ ID
COMP ID
AGCCCGGGGGGCAGGCAT
1541
1558
7035
7052
SEQ ID
ATGCCTGCCCGCCGGGCT
1.34

1930
1930

3558

SEQ ID
COMP ID
GAAGCCCGGCGGGCAGGC
1543
1560
7037
7054
SEQ ID
GCCTGCCCGCCGGGCTTC
no data

1931
1931

3559

SEQ ID
COMP ID
AGGAAGCCCGGCGGGCAG
1545
1562
7039
7056
SEQ ID
CTGCCCGCCGGGCTTCCT
1.48

1932
1932

3560

SEQ ID
COMP ID
TAAGGAAGCCCGGGGGGC
1547
1564
7041
7058
SEQ ID
GCCCGCCGGGCTTCCTTA
1.54

1933
1933

3561

SEQ ID
COMP ID
GATAAGGAAGCCCGGCGG
1549
1566
7043
7060
SEQ ID
CCGCCGGGCTTCCTTATC
no data

1934
1934

3562

SEQ ID
COMP ID
GGGATAAGGAAGCCCGGC
1551
1568
7045
7062
SEQ ID
GCCGGGCTTCCTTATCCC
no data

1935
1935

3563

SEQ ID
COMP ID
GTGGGATAAGGAAGCCCG
1553
1570
7047
7064
SEQ ID
CGGGCTTCCTTATCCCAC
no data

1936
1936

3564

SEQ ID
COMP ID
GGGTGGGATAAGGAAGCC
1555
1572
7049
7066
SEQ ID
GGCTTCCTTATCCCACCC
no data

1937
1937

3565

SEQ ID
COMP ID
TGGGGTGGGATAAGGAAG
1557
1574
7051
7068
SEQ ID
CTTCCTTATCCCACCCCA
2.09

1938
1938

3566

SEQ ID
COMP ID
TCTGGGGTGGGATAAGGA
1559
1576
7053
7070
SEQ ID
TCCTTATCCCACCCCAGA
2.2

1939
1939

3567

SEQ ID
COMP ID
TCTCTGGGGTGGGATAAG
1561
1578
7055
7072
SEQ ID
CTTATCCCACCCCAGAGA
2.51

1940
1940

3568

SEQ ID
COMP ID
TGTCTCTGGGGTGGGATA
1563
1580
7057
7074
SEQ ID
TATCCCACCCCAGAGACA
2.49

1941
1941

3569

SEQ ID
COMP ID
GATGTCTCTGGGGTGGGA
1565
1582
7059
7076
SEQ ID
TCCCACCCCAGAGACATC
no data

1942
1942

3570

SEQ ID
COMP ID
CCGATGTCTCTGGGGTGG
1567
1584
7061
7078
SEQ ID
CCACCCCAGAGACATCGG
2.04

1943
1943

3571

SEQ ID
COMP ID
AGCCGATGTCTCTGGGGT
1569
1586
7063
7080
SEQ ID
ACCCCAGAGACATCGGCT
1.96

1944
1944

3572

SEQ ID
COMP ID
ACAGCCGATGTCTCTGGG
1571
1588
7065
7082
SEQ ID
CCCAGAGACATCGGCTGT
1.45

1945
1945

3573

SEQ ID
COMP ID
TCACAGCCGATGTCTCTG
1573
1590
7067
7084
SEQ ID
CAGAGACATCGGCTGTGA
1.39

1946
1946

3574

SEQ ID
COMP ID
GGTCACAGCCGATGTCTC
1575
1592
7069
7086
SEQ ID
GAGACATCGGCTGTGACC
no data

1947
1947

3575

SEQ ID
COMP ID
CTGGTCACAGCCGATGTC
1577
1594
7071
7088
SEQ ID
GACATCGGCTGTGACCAG
1.68

1948
1948

3576

SEQ ID
COMP ID
TGCTGGTCACAGCCGATG
1579
1596
7073
7090
SEQ ID
CATCGGCTGTGACCAGCA
1.41

1949
1949

3577

SEQ ID
COMP ID
TGTGCTGGTCACAGCCGA
1581
1598
7075
7092
SEQ ID
TCGGCTGTGACCAGCACA
1.66

1950
1950

3578

SEQ ID
COMP ID
GGTGTGCTGGTCACAGCC
1583
1600
7077
7094
SEQ ID
GGCTGTGACCAGCACACC
no data

1951
1951

3579

SEQ ID
COMP ID
CTGGTGTGCTGGTCACAG
1585
1602
7079
7096
SEQ ID
CTGTGACCAGCACACCAG
1.66

1952
1952

3580

SEQ ID
COMP ID
AGCTGGTGTGCTGGTCAC
1587
1604
7081
7098
SEQ ID
GTGACCAGCACACCAGCT
1.23

1953
1953

3581

SEQ ID
COMP ID
GCAGCTGGTGTGCTGGTC
1589
1606
7083
7100
SEQ ID
GACCAGCACACCAGCTGC
no data

1954
1954

3582

SEQ ID
COMP ID
GGGCAGCTGGTGTGCTGG
1591
1608
7085
7102
SEQ ID
CCAGCACACCAGCTGCCC
no data

1955
1955

3583

SEQ ID
COMP ID
CCGGGCAGCTGGTGTGCT
1593
1610
7087
7104
SEQ ID
AGCACACCAGCTGCCCGG
1.54

1956
1956

3584

SEQ ID
COMP ID
CACCGGGCAGCTGGTGTG
1595
1612
7089
7106
SEQ ID
CACACCAGCTGCCCGGTG
1.26

1957
1957

3585

SEQ ID
COMP ID
CCCACCGGGCAGCTGGTG
1597
1614
7091
7108
SEQ ID
CACCAGCTGCCCGGTGGG
1.28

1958
1958

3586

SEQ ID
COMP ID
GCCCCACCGGGCAGCTGG
1599
1616
7093
7110
SEQ ID
CCAGCTGCCCGGTGGGGC
no data

1959
1959

3587

SEQ ID
COMP ID
CTGCCCCACCGGGCAGCT
1601
1618
7095
7112
SEQ ID
AGCTGCCCGGTGGGGCAG
1.46

1960
1960

3588

SEQ ID
COMP ID
GTCTGCCCCACCGGGCAG
1603
1620
7097
7114
SEQ ID
CTGCCCGGTGGGGCAGAC
no data

1961
1961

3589

SEQ ID
COMP ID
AGGTCTGCCCCACCGGGC
1605
1622
7099
7116
SEQ ID
GCCCGGTGGGGCAGACCT
1.21

1962
1962

3590

SEQ ID
COMP ID
GCAGGTCTGCCCCACCGG
1607
1624
7101
7118
SEQ ID
CCGGTGGGGCAGACCTGC
no data

1963
1963

3591

SEQ ID
COMP ID
CAGCAGGTCTGCCCCACC
1609
1626
7103
7120
SEQ ID
GGTGGGGCAGACCTGCTG
1.33

1964
1964

3592

SEQ ID
COMP ID
GGCAGCAGGTCTGCCCCA
1611
1628
7105
7122
SEQ ID
TGGGGCAGACCTGCTGCC
no data

1965
1965

3593

SEQ ID
COMP ID
CGGGCAGCAGGTCTGCCC
1613
1630
7107
7124
SEQ ID
GGGCAGACCTGCTGCCCG
1.52

1966
1966

3594

SEQ ID
COMP ID
CTCGGGCAGCAGGTCTGC
1615
1632
7109
7126
SEQ ID
GCAGACCTGCTGCCCGAG
1.2

1967
1967

3595

SEQ ID
COMP ID
GGCTCGGGCAGCAGGTCT
1617
1634
7111
7128
SEQ ID
AGACCTGCTGCCCGAGCC
no data

1968
1968

3596

SEQ ID
COMP ID
CAGGCTCGGGCAGCAGGT
1619
1636
7113
7130
SEQ ID
ACCTGCTGCCCGAGCCTG
no data

1969
1969

3597

SEQ ID
COMP ID
CCCAGGCTCGGGCAGCAG
1621
1638
7115
7132
SEQ ID
CTGCTGCCCGAGCCTGGG
1.2

1970
1970

3598

SEQ ID
COMP ID
CACCCAGGCTCGGGCAGC
1623
1640
7117
7134
SEQ ID
GCTGCCCGAGCCTGGGTG
1.41

1971
1971

3599

SEQ ID
COMP ID
CCCACCCAGGCTCGGGCA
1625
1642
7119
7136
SEQ ID
TGCCCGAGCCTGGGTGGG
1.24

1972
1972

3600

SEQ ID
COMP ID
CTCCCACCCAGGCTCGGG
1627
1644
7121
7138
SEQ ID
CCCGAGCCTGGGTGGGAG
1.06

1973
1973

3601

SEQ ID
COMP ID
AGCTCCCACCCAGGCTCG
1629
1646
7123
7140
SEQ ID
CGAGCCTGGGTGGGAGCT
1.24

1974
1974

3602

SEQ ID
COMP ID
CCAGCTCCCACCCAGGCT
1631
1648
7125
7142
SEQ ID
AGCCTGGGTGGGAGCTGG
1.1

1975
1975

3603

SEQ ID
COMP ID
GCCCAGCTCCCACCCAGG
1633
1650
7127
7144
SEQ ID
CCTGGGTGGGAGCTGGGC
no data

1976
1976

3604

SEQ ID
COMP ID
AGGCCCAGCTCCCACCCA
1635
1652
7129
7146
SEQ ID
TGGGTGGGAGCTGGGCCT
1.08

1977
1977

3605

SEQ ID
COMP ID
GCAGGCCCAGCTCCCACC
1637
1654
7131
7148
SEQ ID
GGTGGGAGCTGGGCCTGC
no data

1978
1978

3606

SEQ ID
COMP ID
CAGCAGGCCCAGCTCCCA
1639
1656
7133
7150
SEQ ID
TGGGAGCTGGGCCTGCTG
1.24

1979
1979

3607

SEQ ID
COMP ID
GGCAGCAGGCCCAGCTCC
1641
1658
7135
7152
SEQ ID
GGAGCTGGGCCTGCTGCC
no data

1980
1980

3608

SEQ ID
COMP ID
CTGGCAGCAGGCCCAGCT
1643
1660
7137
7154
SEQ ID
AGCTGGGCCTGCTGCCAG
1.49

1981
1981

3609

SEQ ID
COMP ID
AACTGGCAGCAGGCCCAG
1645
1662
7139
7156
SEQ ID
CTGGGCCTGCTGCCAGTT
1.25

1982
1982

3610

SEQ ID
COMP ID
GCAACTGGCAGCAGGCCC
1647
1664
7141
7158
SEQ ID
GGGCCTGCTGCCAGTTGC
no data

1983
1983

3611

SEQ ID
COMP ID
GGGCAACTGGCAGCAGGC
1649
1666
7143
7160
SEQ ID
GCCTGCTGCCAGTTGCCC
no data

1984
1984

3612

SEQ ID
COMP ID
TGGGGCAACTGGCAGCAG
1651
1668
7145
7162
SEQ ID
CTGCTGCCAGTTGCCCCA
2.46

1985
1985

3613

SEQ ID
COMP ID
CATGGGGCAACTGGCAGC
1653
1670
7147
7164
SEQ ID
GCTGCCAGTTGCCCCATG
2.39

1986
1986

3614

SEQ ID
COMP ID
CACATGGGGCAACTGGCA

7149
7166
SEQ ID
TGCCAGTTGCCCCATGTG
1.23

1987
1987

3615

SEQ ID
COMP ID
CTCACATGGGGCAACTGG

7151
7168
SEQ ID
CCAGTTGCCCCATGTGAG
1.23

1988
1988

3616

SEQ ID
COMP ID
CACTCACATGGGGCAACT

7153
7170
SEQ ID
AGTTGCCCCATGTGAGTG
1.03

1989
1989

3617

SEQ ID
COMP ID
GGCACTCACATGGGGCAA

7155
7172
SEQ ID
TTGCCCCATGTGAGTGCC
no data

1990
1990

3618

SEQ ID
COMP ID
GAGGCACTCACATGGGGC

7157
7174
SEQ ID
GCCCCATGTGAGTGCCTC
no data

1991
1991

3619

SEQ ID
COMP ID
GGGAGGCACTCACATGGG

7159
7176
SEQ ID
CCCATGTGAGTGCCTCCC
no data

1992
1992

3620

SEQ ID
COMP ID
CAGGGAGGCACTCACATG

7161
7178
SEQ ID
CATGTGAGTGCCTCCCTG
1.3

1993
1993

3621

SEQ ID
COMP ID
GGCAGGGAGGCACTCACA

7163
7180
SEQ ID
TGTGAGTGCCTCCCTGCC
no data

1994
1994

3622

SEQ ID
COMP ID
CAGGCAGGGAGGCACTCA

7165
7182
SEQ ID
TGAGTGCCTCCCTGCCTG
1.14

1995
1995

3623

SEQ ID
COMP ID
GGCAGGCAGGGAGGCACT

7167
7184
SEQ ID
AGTGCCTCCCTGCCTGCC
2.25

1996
1996

3624

SEQ ID
COMP ID
GGGGCAGGCAGGGAGGCA

7169
7186
SEQ ID
TGCCTCCCTGCCTGCCCC
2.22

1997
1997

3625

SEQ ID
COMP ID
CAGGGGCAGGCAGGGAGG

7171
7188
SEQ ID
CCTCCCTGCCTGCCCCTG
1.69

1998
1998

3626

SEQ ID
COMP ID
TCCAGGGGCAGGCAGGGA

7173
7190
SEQ ID
TCCCTGCCTGCCCCTGGA
2.17

1999
1999

3627

SEQ ID
COMP ID
TATCCAGGGGCAGGCAGG

7175
7192
SEQ ID
CCTGCCTGCCCCTGGATA
1.76

2000
2000

3628

SEQ ID
COMP ID
CCTATCCAGGGGCAGGCA

7177
7194
SEQ ID
TGCCTGCCCCTGGATAGG
1.3

2001
2001

3629

SEQ ID
COMP ID
CCCCTATCCAGGGGCAGG

7179
7196
SEQ ID
CCTGCCCCTGGATAGGGG
1.02

2002
2002

3630

SEQ ID
COMP ID
CTCCCCTATCCAGGGGCA

7181
7198
SEQ ID
TGCCCCTGGATAGGGGAG
1.16

2003
2003

3631

SEQ ID
COMP ID
AGCTCCCCTATCCAGGGG

7183
7200
SEQ ID
CCCCTGGATAGGGGAGCT
1.39

2004
2004

3632

SEQ ID
COMP ID
TTAGCTCCCCTATCCAGG

7185
7202
SEQ ID
CCTGGATAGGGGAGCTAA
1.54

2005
2005

3633

SEQ ID
COMP ID
GCTTAGCTCCCCTATCCA

7187
7204
SEQ ID
TGGATAGGGGAGCTAAGC
no data

2006
2006

3634

SEQ ID
COMP ID
GGGCTTAGCTCCCCTATC

7189
7206
SEQ ID
GATAGGGGAGCTAAGCCC
no data

2007
2007

3635

SEQ ID
COMP ID
CTGGGCTTAGCTCCCCTA

7191
7208
SEQ ID
TAGGGGAGCTAAGCCCAG
1.31

2008
2008

3636

SEQ ID
COMP ID
CACTGGGCTTAGCTCCCC

7193
7210
SEQ ID
GGGGAGCTAAGCCCAGTG
1.15

2009
2009

3637

SEQ ID
COMP ID
CTCACTGGGCTTAGCTCC

7195
7212
SEQ ID
GGAGCTAAGCCCAGTGAG
1.15

2010
2010

3638

SEQ ID
COMP ID
CCCTCACTGGGCTTAGCT

7197
7214
SEQ ID
AGCTAAGCCCAGTGAGGG
1.25

2011
2011

3639

SEQ ID
COMP ID
GTTCCTGTCCCCTCACTG

7206
7223
SEQ ID
CAGTGAGGGGACAGGAAC
no data

2012
2012

3640

SEQ ID
COMP ID
ATGTTCCTGTCCCCTCAC

7208
7225
SEQ ID
GTGAGGGGACAGGAACAT
1.51

2013
2013

3641

SEQ ID
COMP ID
TTATGTTCCTGTCCCCTC

7210
7227
SEQ ID
GAGGGGACAGGAACATAA
1.44

2014
2014

3642

SEQ ID
COMP ID
CATTATGTTCCTGTCCCC

7212
7229
SEQ ID
GGGGACAGGAACATAATG
1.61

2015
2015

3643

SEQ ID
COMP ID
GGCATTATGTTCCTGTCC

7214
7231
SEQ ID
GGACAGGAACATAATGCC
no data

2016
2016

3644

SEQ ID
COMP ID
ATGGCATTATGTTCCTGT

7216
7233
SEQ ID
ACAGGAACATAATGCCAT
1.28

2017
2017

3645

SEQ ID
COMP ID
GAATGGCATTATGTTCCT

7218
7235
SEQ ID
AGGAACATAATGCCATTC
no data

2018
2018

3646

SEQ ID
COMP ID
CAGAATGGCATTATGTTC

7220
7237
SEQ ID
GAACATAATGCCATTCTG
1.34

2019
2019

3647

SEQ ID
COMP ID
CACAGAATGGCATTATGT

7222
7239
SEQ ID
ACATAATGCCATTCTGTG
1.51

2020
2020

3648

SEQ ID
COMP ID
AGCACAGAATGGCATTAT

7224
7241
SEQ ID
ATAATGCCATTCTGTGCT
1.46

2021
2021

3649

SEQ ID
COMP ID
GGAGCACAGAATGGCATT

7226
7243
SEQ ID
AATGCCATTCTGTGCTCC
no data

2022
2022

3650

SEQ ID
COMP ID
AGGGAGCACAGAATGGCA

7228
7245
SEQ ID
TGCCATTCTGTGCTCCCT
1.88

2023
2023

3651

SEQ ID
COMP ID
GAAGGGAGCACAGAATGG

7230
7247
SEQ ID
CCATTCTGTGCTCCCTTC
no data

2024
2024

3652

SEQ ID
COMP ID
GGGAAGGGAGCACAGAAT

7232
7249
SEQ ID
ATTCTGTGCTCCCTTCCC
no data

2025
2025

3653

SEQ ID
COMP ID
CGGGGAAGGGAGCACAGA

7234
7251
SEQ ID
TCTGTGCTCCCTTCCCCG
2.53

2026
2026

3654

SEQ ID
COMP ID
GGCGGGGAAGGGAGCACA

7236
7253
SEQ ID
TGTGCTCCCTTCCCCGCC
no data

2027
2027

3655

SEQ ID
COMP ID
CTGGCGGGGAAGGGAGCA

7238
7255
SEQ ID
TGCTCCCTTCCCCGCCAG
2.66

2028
2028

3656

SEQ ID
COMP ID
GCCTGGCGGGGAAGGGAG

7240
7257
SEQ ID
CTCCCTTCCCCGCCAGGC
no data

2029
2029

3657

SEQ ID
COMP ID
CAGCCTGGGGGGGAAGGG

7242
7259
SEQ ID
CCCTTCCCCGCCAGGCTG
no data

2030
2030

3658

SEQ ID
COMP ID
CACAGCCTGGCGGGGAAG

7244
7261
SEQ ID
CTTCCCCGCCAGGCTGTG
2.31

2031
2031

3659

SEQ ID
COMP ID
CACACAGCCTGGCGGGGA

7246
7263
SEQ ID
TCCCCGCCAGGCTGTGTG
1.88

2032
2032

3660

SEQ ID
COMP ID
AGCACACAGCCTGGCGGG

7248
7265
SEQ ID
CCCGCCAGGCTGTGTGCT
2

2033
2033

3661

SEQ ID
COMP ID
GCAGCACACAGCCTGGCG

7250
7267
SEQ ID
CGCCAGGCTGTGTGCTGC
no data

2034
2034

3662

SEQ ID
COMP ID
TCGCAGCACACAGCCTGG

7252
7269
SEQ ID
CCAGGCTGTGTGCTGCGA
1.26

2035
2035

3663

SEQ ID
COMP ID
CCTCGCAGCACACAGCCT

7254
7271
SEQ ID
AGGCTGTGTGCTGCGAGG
1.35

2036
2036

3664

SEQ ID
COMP ID
ATCCTCGCAGCACACAGC
1670
1687
7256
7273
SEQ ID
GCTGTGTGCTGCGAGGAT
1.4

2037
2037

3665

SEQ ID
COMP ID
CGATCCTCGCAGCACACA
1672
1689
7258
7275
SEQ ID
TGTGTGCTGCGAGGATCG
1.21

2038
2038

3666

SEQ ID
COMP ID
GGCGATCCTCGCAGCACA
1674
1691
7260
7277
SEQ ID
TGTGCTGCGAGGATCGCC
no data

2039
2039

3667

SEQ ID
COMP ID
CTGGCGATCCTCGCAGCA
1676
1693
7262
7279
SEQ ID
TGCTGCGAGGATCGCCAG
no data

2040
2040

3668

SEQ ID
COMP ID
TGCTGGCGATCCTCGCAG
1678
1695
7264
7281
SEQ ID
CTGCGAGGATCGCCAGCA
0.52

2041
2041

3669

SEQ ID
COMP ID
AGTGCTGGCGATCCTCGC
1680
1697
7266
7283
SEQ ID
GCGAGGATCGCCAGCACT
1.75

2042
2042

3670

SEQ ID
COMP ID
GCAGTGCTGGCGATCCTC
1682
1699
7268
7285
SEQ ID
GAGGATCGCCAGCACTGC
no data

2043
2043

3671

SEQ ID
COMP ID
CAGCAGTGCTGGCGATCC
1684
1701
7270
7287
SEQ ID
GGATCGCCAGCACTGCTG
1.45

2044
2044

3672

SEQ ID
COMP ID
GGCAGCAGTGCTGGCGAT
1686
1703
7272
7289
SEQ ID
ATCGCCAGCACTGCTGCC
no data

2045
2045

3673

SEQ ID
COMP ID
CGGGCAGCAGTGCTGGCG
1688
1705
7274
7291
SEQ ID
CGCCAGCACTGCTGCCCG
0.55

2046
2046

3674

SEQ ID
COMP ID
GCCGGGCAGCAGTGCTGG
1690
1707
7276
7293
SEQ ID
CCAGCACTGCTGCCCGGC
no data

2047
2047

3675

SEQ ID
COMP ID
CAGCCGGGCAGCAGTGCT
1692
1709
7278
7295
SEQ ID
AGCACTGCTGCCCGGCTG
1.76

2048
2048

3676

SEQ ID
COMP ID
GCCAGCCGGGCAGCAGTG
1694
1711
7280
7297
SEQ ID
CACTGCTGCCCGGCTGGC
no data

2049
2049

3677

SEQ ID
COMP ID
TAGCCAGCCGGGCAGCAG
1696
1713
7282
7299
SEQ ID
CTGCTGCCCGGCTGGCTA
1.31

2050
2050

3678

SEQ ID
COMP ID
TGTAGCCAGCCGGGCAGC
1698
1715
7284
7301
SEQ ID
GCTGCCCGGCTGGCTACA
1.35

2051
2051

3679

SEQ ID
COMP ID
GGTGTAGCCAGCCGGGCA
1700
1717
7286
7303
SEQ ID
TGCCCGGCTGGCTACACC
1.71

2052
2052

3680

SEQ ID
COMP ID
CAGGTGTAGCCAGCCGGG
1702
1719
7288
7305
SEQ ID
CCCGGCTGGCTACACCTG
1.56

2053
2053

3681

SEQ ID
COMP ID
TGCAGGTGTAGCCAGCCG
1704
1721
7290
7307
SEQ ID
CGGCTGGCTACACCTGCA
1.43

2054
2054

3682

SEQ ID
COMP ID
GTTGCAGGTGTAGCCAGC
1706
1723
7292
7309
SEQ ID
GCTGGCTACACCTGCAAC
1.76

2055
2055

3683

SEQ ID
COMP ID
ACGTTGCAGGTGTAGCCA
1708
1725
7294
7311
SEQ ID
TGGCTACACCTGCAACGT
1.5

2056
2056

3684

SEQ ID
COMP ID
TCACGTTGCAGGTGTAGC
1710
1727
7296
7313
SEQ ID
GCTACACCTGCAACGTGA
1.54

2057
2057

3685

SEQ ID
COMP ID
CTTCACGTTGCAGGTGTA
1712
1729
7298
7315
SEQ ID
TACACCTGCAACGTGAAG
1.75

2058
2058

3686

SEQ ID
COMP ID
GCCTTCACGTTGCAGGTG
1714
1731
7300
7317
SEQ ID
CACCTGCAACGTGAAGGC
1.76

2059
2059

3687

SEQ ID
COMP ID
GAGCCTTCACGTTGCAGG
1716
1733
7302
7319
SEQ ID
CCTGCAACGTGAAGGCTC
1.72

2060
2060

3688

SEQ ID
COMP ID
TCGAGCCTTCACGTTGCA
1718
1735
7304
7321
SEQ ID
TGCAACGTGAAGGCTCGA
2.03

2061
2061

3689

SEQ ID
COMP ID
GATCGAGCCTTCACGTTG
1720
1737
7306
7323
SEQ ID
CAACGTGAAGGCTCGATC
1.41

2062
2062

3690

SEQ ID
COMP ID
AGGATCGAGCCTTCACGT
1722
1739
7308
7325
SEQ ID
ACGTGAAGGCTCGATCCT
1.77

2063
2063

3691

SEQ ID
COMP ID
GCAGGATCGAGCCTTCAC
1724
1741
7310
7327
SEQ ID
GTGAAGGCTCGATCCTGC
1.37

2064
2064

3692

SEQ ID
COMP ID
TCGCAGGATCGAGCCTTC
1726
1743
7312
7329
SEQ ID
GAAGGCTCGATCCTGCGA
1.54

2065
2065

3693

SEQ ID
COMP ID
TCTCGCAGGATCGAGCCT
1728
1745
7314
7331
SEQ ID
AGGCTCGATCCTGCGAGA
1.55

2066
2066

3694

SEQ ID
COMP ID
CTTCTCGCAGGATCGAGC
1730
1747
7316
7333
SEQ ID
GCTCGATCCTGCGAGAAG
1.54

2067
2067

3695

SEQ ID
COMP ID
TCCTTCTCGCAGGATCGA
1732
1749
7318
7335
SEQ ID
TCGATCCTGCGAGAAGGA
1.53

2068
2068

3696

SEQ ID
COMP ID
CTTCCTTCTCGCAGGATC
1734
1751
7320
7337
SEQ ID
GATCCTGCGAGAAGGAAG
1.21

2069
2069

3697

SEQ ID
COMP ID
CACTTCCTTCTCGCAGGA
1736
1753
7322
7339
SEQ ID
TCCTGCGAGAAGGAAGTG
1.89

2070
2070

3698

SEQ ID
COMP ID
ACCACTTCCTTCTCGCAG
1738
1755
7324
7341
SEQ ID
CTGCGAGAAGGAAGTGGT
1.49

2071
2071

3699

SEQ ID
COMP ID
AGACCACTTCCTTCTCGC
1740
1757
7326
7343
SEQ ID
GCGAGAAGGAAGTGGTCT
1.54

2072
2072

3700

SEQ ID
COMP ID
AGAGACCACTTCCTTCTC
1742
1759
7328
7345
SEQ ID
GAGAAGGAAGTGGTCTCT
1.52

2073
2073

3701

SEQ ID
COMP ID
GCAGAGACCACTTCCTTC
1744
1761
7330
7347
SEQ ID
GAAGGAAGTGGTCTCTGC
1.38

2074
2074

3702

SEQ ID
COMP ID
GGGCAGAGACCACTTCCT
1746
1763
7332
7349
SEQ ID
AGGAAGTGGTCTCTGCCC
1.54

2075
2075

3703

SEQ ID
COMP ID
CTGGGCAGAGACCACTTC
1748
1765
7334
7351
SEQ ID
GAAGTGGTCTCTGCCCAG
1.5

2076
2076

3704

SEQ ID
COMP ID
GGCTGGGCAGAGACCACT
1750
1767
7336
7353
SEQ ID
AGTGGTCTCTGCCCAGCC
1.37

2077
2077

3705

SEQ ID
COMP ID
CAGGCTGGGCAGAGACCA
1752
1769
7338
7355
SEQ ID
TGGTCTCTGCCCAGCCTG
1.24

2078
2078

3706

SEQ ID
COMP ID
GGCAGGCTGGGCAGAGAC
1754
1771
7340
7357
SEQ ID
GTCTCTGCCCAGCCTGCC
1.59

2079
2079

3707

SEQ ID
COMP ID
GTGGCAGGCTGGGCAGAG
1756
1773
7342
7359
SEQ ID
CTCTGCCCAGCCTGCCAC
1.83

2080
2080

3708

SEQ ID
COMP ID
AGGTGGCAGGCTGGGCAG
1758
1775
7344
7361
SEQ ID
CTGCCCAGCCTGCCACCT
2.4

2081
2081

3709

SEQ ID
COMP ID
GAAGGTGGCAGGCTGGGC
1760
1777
7346
7363
SEQ ID
GCCCAGCCTGCCACCTTC
2.38

2082
2082

3710

SEQ ID
COMP ID
AGGAAGGTGGCAGGCTGG
1762
1779
7348
7365
SEQ ID
CCAGCCTGCCACCTTCCT
2.34

2083
2083

3711

SEQ ID
COMP ID
CCAGGAAGGTGGCAGGCT
1764
1781
7350
7367
SEQ ID
AGCCTGCCACCTTCCTGG
1.97

2084
2084

3712

SEQ ID
COMP ID
GGCCAGGAAGGTGGCAGG
1766
1783
7352
7369
SEQ ID
CCTGCCACCTTCCTGGCC
1.51

2085
2085

3713

SEQ ID
COMP ID
CGGGCCAGGAAGGTGGCA
1768
1785
7354
7371
SEQ ID
TGCCACCTTCCTGGCCCG
1.58

2086
2086

3714

SEQ ID
COMP ID
TACGGGCCAGGAAGGTGG
1770
1787
7356
7373
SEQ ID
CCACCTTCCTGGCCCGTA
1.54

2087
2087

3715

SEQ ID
COMP ID
GCTACGGGCCAGGAAGGT
1772
1789
7358
7375
SEQ ID
ACCTTCCTGGCCCGTAGC
1.96

2088
2088

3716

SEQ ID
COMP ID
GGGCTACGGGCCAGGAAG
1774
1791
7360
7377
SEQ ID
CTTCCTGGCCCGTAGCCC
1.89

2089
2089

3717

SEQ ID
COMP ID
GAGGGCTACGGGCCAGGA
1776
1793
7362
7379
SEQ ID
TCCTGGCCCGTAGCCCTC
1.81

2090
2090

3718

SEQ ID
COMP ID
GTGAGGGCTACGGGCCAG
1778
1795
7364
7381
SEQ ID
CTGGCCCGTAGCCCTCAC
1.54

2091
2091

3719

SEQ ID
COMP ID
ACGTGAGGGCTACGGGCC
1780
1797
7366
7383
SEQ ID
GGCCCGTAGCCCTCACGT
1.6

2092
2092

3720

SEQ ID
COMP ID
CCACGTGAGGGCTACGGG
1782
1799
7368
7385
SEQ ID
CCCGTAGCCCTCACGTGG
2.07

2093
2093

3721

SEQ ID
COMP ID
ACCCACGTGAGGGCTACG
1784
1801
7370
7387
SEQ ID
CGTAGCCCTCACGTGGGT
1.51

2094
2094

3722

SEQ ID
COMP ID
ACACCCACGTGAGGGCTA
1786
1803
7372
7389
SEQ ID
TAGCCCTCACGTGGGTGT
1.95

2095
2095

3723

SEQ ID
COMP ID
TCACACCCACGTGAGGGC
1788
1805
7374
7391
SEQ ID
GCCCTCACGTGGGTGTGA
1.32

2096
2096

3724

SEQ ID
COMP ID
CTTCACACCCACGTGAGG
1790
1807
7376
7393
SEQ ID
CCTCACGTGGGTGTGAAG
1.94

2097
2097

3725

SEQ ID
COMP ID
TCCTTCACACCCACGTGA
1792
1809
7378
7395
SEQ ID
TCACGTGGGTGTGAAGGA
1.31

2098
2098

3726

SEQ ID
COMP ID
CGTCCTTCACACCCACGT
1794
1811
7380
7397
SEQ ID
ACGTGGGTGTGAAGGACG
1.08

2099
2099

3727

SEQ ID
COMP ID
CACGTCCTTCACACCCAC
1796
1813
7382
7399
SEQ ID
GTGGGTGTGAAGGACGTG
0.95

2100
2100

3728

SEQ ID
COMP ID
TCCACGTCCTTCACACCC
1798
1815
7384
7401
SEQ ID
GGGTGTGAAGGACGTGGA
1.16

2101
2101

3729

SEQ ID
COMP ID
ACTCCACGTCCTTCACAC
1800
1817
7386
7403
SEQ ID
GTGTGAAGGACGTGGAGT
1.05

2102
2102

3730

SEQ ID
COMP ID
ACACTCCACGTCCTTCAC
1802
1819
7388
7405
SEQ ID
GTGAAGGACGTGGAGTGT
1.35

2103
2103

3731

SEQ ID
COMP ID
CCACACTCCACGTCCTTC
1804
1821
7390
7407
SEQ ID
GAAGGACGTGGAGTGTGG
1.02

2104
2104

3732

SEQ ID
COMP ID
CCCCACACTCCACGTCCT
1806
1823
7392
7409
SEQ ID
AGGACGTGGAGTGTGGGG
1.2

2105
2105

3733

SEQ ID
COMP ID
TTCCCCACACTCCACGTC
1808
1825
7394
7411
SEQ ID
GACGTGGAGTGTGGGGAA
1.18

2106
2106

3734

SEQ ID
COMP ID
CCTTCCCCACACTCCACG
1810
1827
7396
7413
SEQ ID
CGTGGAGTGTGGGGAAGG
1.1

2107
2107

3735

SEQ ID
COMP ID
GTCCTTCCCCACACTCCA
1812
1829
7398
7415
SEQ ID
TGGAGTGTGGGGAAGGAC
1.36

2108
2108

3736

SEQ ID
COMP ID
GTGTCCTTCCCCACACTC
1814
1831
7400
7417
SEQ ID
GAGTGTGGGGAAGGACAC
1.45

2109
2109

3737

SEQ ID
COMP ID
AAGTGTCCTTCCCCACAC
1816
1833
7402
7419
SEQ ID
GTGTGGGGAAGGACACTT
1.26

2110
2110

3738

SEQ ID
COMP ID
AGAAGTGTCCTTCCCCAC
1818
1835
7404
7421
SEQ ID
GTGGGGAAGGACACTTCT
1.44

2111
2111

3739

SEQ ID
COMP ID
GCAGAAGTGTCCTTCCCC
1820
1837
7406
7423
SEQ ID
GGGGAAGGACACTTCTGC
1.16

2112
2112

3740

SEQ ID
COMP ID
TGGCAGAAGTGTCCTTCC
1822
1839
7408
7425
SEQ ID
GGAAGGACACTTCTGCCA
1.42

2113
2113

3741

SEQ ID
COMP ID
CATGGCAGAAGTGTCCTT
1824
1841
7410
7427
SEQ ID
AAGGACACTTCTGCCATG
1.12

2114
2114

3742

SEQ ID
COMP ID
ATCATGGCAGAAGTGTCC
1826
1843
7412
7429
SEQ ID
GGACACTTCTGCCATGAT
1.44

2115
2115

3743

SEQ ID
COMP ID
TTATCATGGCAGAAGTGT
1828
1845
7414
7431
SEQ ID
ACACTTCTGCCATGATAA
1.57

2116
2116

3744

SEQ ID
COMP ID
GGTTATCATGGCAGAAGT
1830
1847
7416
7433
SEQ ID
ACTTCTGCCATGATAACC
1.48

2117
2117

3745

SEQ ID
COMP ID
CTGGTTATCATGGCAGAA
1832
1849
7418
7435
SEQ ID
TTCTGCCATGATAACCAG
1.49

2118
2118

3746

SEQ ID
COMP ID
GTCTGGTTATCATGGCAG
1834
1851
7420
7437
SEQ ID
CTGCCATGATAACCAGAC
1.72

2119
2119

3747

SEQ ID
COMP ID
AGGTCTGGTTATCATGGC
1836
1853
7422
7439
SEQ ID
GCCATGATAACCAGACCT
1.71

2120
2120

3748

SEQ ID
COMP ID
GCAGGTCTGGTTATCATG
1838
1855
7424
7441
SEQ ID
CATGATAACCAGACCTGC
1.59

2121
2121

3749

SEQ ID
COMP ID
CAGCAGGTCTGGTTATCA
1840
1857
7426
7443
SEQ ID
TGATAACCAGACCTGCTG
1.56

2122
2122

3750

SEQ ID
COMP ID
GGCAGCAGGTCTGGTTAT
1842
1859
7428
7445
SEQ ID
ATAACCAGACCTGCTGCC
1.54

2123
2123

3751

SEQ ID
COMP ID
TCGGCAGCAGGTCTGGTT
1844
1861
7430
7447
SEQ ID
AACCAGACCTGCTGCCGA
1.89

2124
2124

3752

SEQ ID
COMP ID
TCTCGGCAGCAGGTCTGG
1846
1863
7432
449
SEQ ID
CCAGACCTGCTGCCGAGA
1.54

2125
2125

3753

SEQ ID
COMP ID
TGTCTCGGCAGCAGGTCT
1848
1865
7434
7451
SEQ ID
AGACCTGCTGCCGAGACA
1.58

2126
2126

3754

SEQ ID
COMP ID
GTTGTCTCGGCAGCAGGT
1850
1867
7436
7453
SEQ ID
ACCTGCTGCCGAGACAAC
1.58

2127
2127

3755

SEQ ID
COMP ID
CGGTTGTCTCGGCAGCAG
1852
1869
7438
7455
SEQ ID
CTGCTGCCGAGACAACCG
no data

2128
2128

3756

SEQ ID
COMP ID
GTCGGTTGTCTCGGCAGC
1854
1871
7440
7457
SEQ ID
GCTGCCGAGACAACCGAC
no data

2129
2129

3757

SEQ ID
COMP ID
CTGTCGGTTGTCTCGGCA
1856
1873
7442
7459
SEQ ID
TGCCGAGACAACCGACAG
no data

2130
2130

3758

SEQ ID
COMP ID
CCCTGTCGGTTGTCTCGG
1858
1875
7444
7461
SEQ ID
CCGAGACAACCGACAGGG
no data

2131
2131

3759

SEQ ID
COMP ID
AGCCCTGTCGGTTGTCTC
1860
1877
7446
7463
SEQ ID
GAGACAACCGACAGGGCT
no data

2132
2132

3760

SEQ ID
COMP ID
CCAGCCCTGTCGGTTGTC
1862
1879
7448
7465
SEQ ID
GACAACCGACAGGGCTGG
no data

2133
2133

3761

SEQ ID
COMP ID
GCCCAGCCCTGTCGGTTG
1864
1881
7450
7467
SEQ ID
CAACCGACAGGGCTGGGC
no data

2134
2134

3762

SEQ ID
COMP ID
AGGCCCAGCCCTGTCGGT
1866
1883
7452
7469
SEQ ID
ACCGACAGGGCTGGGCCT
no data

2135
2135

3763

SEQ ID
COMP ID
GCAGGCCCAGCCCTGTCG
1868
1885
7454
7471
SEQ ID
CGACAGGGCTGGGCCTGC
no data

2136
2136

3764

SEQ ID
COMP ID
CAGCAGGCCCAGCCCTGT
1870
1887
7456
7473
SEQ ID
ACAGGGCTGGGCCTGCTG
no data

2137
2137

3765

SEQ ID
COMP ID
GACAGCAGGCCCAGCCCT
1872
1889
7458
7475
SEQ ID
AGGGCTGGGCCTGCTGTC
no data

2138
2138

3766

SEQ ID
COMP ID
GGGACAGCAGGCCCAGCC
1874
1891
7460
7477
SEQ ID
GGCTGGGCCTGCTGTCCC
no data

2139
2139

3767

SEQ ID
COMP ID
TAGGGACAGCAGGCCCAG
1876
1893
7462
7479
SEQ ID
CTGGGCCTGCTGTCCCTA
no data

2140
2140

3768

SEQ ID
COMP ID
GGTAGGGACAGCAGGCCC
1878
1895
7464
7481
SEQ ID
GGGCCTGCTGTCCCTACC
no data

2141
2141

3769

SEQ ID
COMP ID
GCGGTAGGGACAGCAGGC
1880
1897
7466
7483
SEQ ID
GCCTGCTGTCCCTACCGC
no data

2142
2142

3770

SEQ ID
COMP ID
TGGCGGTAGGGACAGCAG
1882
1899
7468
7485
SEQ ID
CTGCTGTCCCTACCGCCA
no data

2143
2143

3771

SEQ ID
COMP ID
ATGGGGGTTGGCACTGAC

7487
7504
SEQ ID
GTCAGTGCCAACCCCCAT
no data

2144
2144

3772

SEQ ID
COMP ID
GGATGGGGGTTGGCACTG

7489
506
SEQ ID
CAGTGCCAACCCCCATCC
no data

2145
2145

3773

SEQ ID
COMP ID
CAGGATGGGGGTTGGCAC

7491
7508
SEQ ID
GTGCCAACCCCCATCCTG
2.44

2146
2146

3774

SEQ ID
COMP ID
CCCAGGATGGGGGTTGGC

7493
7510
SEQ ID
GCCAACCCCCATCCTGGG
1.56

2147
2147

3775

SEQ ID
COMP ID
GCCCCAGGATGGGGGTTG

7495
7512
SEQ ID
CAACCCCCATCCTGGGGC
1.74

2148
2148

3776

SEQ ID
COMP ID
CAGCCCCAGGATGGGGGT

7497
7514
SEQ ID
ACCCCCATCCTGGGGCTG
1.31

2149
2149

3777

SEQ ID
COMP ID
CCCAGCCCCAGGATGGGG

7499
7516
SEQ ID
CCCCATCCTGGGGCTGGG
1.38

2150
2150

3778

SEQ ID
COMP ID
TACCCAGCCCCAGGATGG

7501
7518
SEQ ID
CCATCCTGGGGCTGGGTA
1.22

2151
2151

3779

SEQ ID
COMP ID
CATACCCAGCCCCAGGAT

7503
7520
SEQ ID
ATCCTGGGGCTGGGTATG
1.33

2152
2152

3780

SEQ ID
COMP ID
GCCATACCCAGCCCCAGG

7505
7522
SEQ ID
CCTGGGGCTGGGTATGGC
1.15

2153
2153

3781

SEQ ID
COMP ID
TGGCCATACCCAGCCCCA

7507
7524
SEQ ID
TGGGGCTGGGTATGGCCA
1.39

2154
2154

3782

SEQ ID
COMP ID
CCTGGCCATACCCAGCCC

7509
7526
SEQ ID
GGGCTGGGTATGGCCAGG
1.13

2155
2155

3783

SEQ ID
COMP ID
TCCCTGGCCATACCCAGC

7511
7528
SEQ ID
GCTGGGTATGGCCAGGGA
1.46

2156
2156

3784

SEQ ID
COMP ID
GGTCCCTGGCCATACCCA

7513
7530
SEQ ID
TGGGTATGGCCAGGGACC
1.1

2157
2157

3785

SEQ ID
COMP ID
CTGGTCCCTGGCCATACC

7515
7532
SEQ ID
GGTATGGCCAGGGACCAG
1.5

2158
2158

3786

SEQ ID
COMP ID
ACCTGGTCCCTGGCCATA

7517
7534
SEQ ID
TATGGCCAGGGACCAGGT
1.16

2159
2159

3787

SEQ ID
COMP ID
GGACCTGGTCCCTGGCCA

7519
7536
SEQ ID
TGGCCAGGGACCAGGTCC
2.1

2160
2160

3788

SEQ ID
COMP ID
GAGGTGGGACCTGGTCCC

7525
7542
SEQ ID
GGGACCAGGTCCCACCTC
1.45

2161
2161

3789

SEQ ID
COMP ID
ACGAGGTGGGACCTGGTC

7527
7544
SEQ ID
GACCAGGTCCCACCTCGT
1.86

2162
2162

3790

SEQ ID
COMP ID
GGACGAGGTGGGACCTGG

7529
7546
SEQ ID
CCAGGTCCCACCTCGTCC
1.63

2163
2163

3791

SEQ ID
COMP ID
TTGGACGAGGTGGGACCT

7531
7548
SEQ ID
AGGTCCCACCTCGTCCAA
1.49

2164
2164

3792

SEQ ID
COMP ID
GGTTGGACGAGGTGGGAC

7533
7550
SEQ ID
GTCCCACCTCGTCCAACC
1.86

2165
2165

3793

SEQ ID
COMP ID
AGGGTTGGACGAGGTGGG

7535
7552
SEQ ID
CCCACCTCGTCCAACCCT
2.12

2166
2166

3794

SEQ ID
COMP ID
AGAGGGTTGGACGAGGTG

7537
7554
SEQ ID
CACCTCGTCCAACCCTCT
1.83

2167
2167

3795

SEQ ID
COMP ID
CGAGAGGGTTGGACGAGG

7539
7556
SEQ ID
CCTCGTCCAACCCTCTCG
1.98

2168
2168

3796

SEQ ID
COMP ID
GGCGAGAGGGTTGGACGA

7541
7558
SEQ ID
TCGTCCAACCCTCTCGCC
1.79

2169
2169

3797

SEQ ID
COMP ID
GGGGCGAGAGGGTTGGAC

7543
7560
SEQ ID
GTCCAACCCTCTCGCCCC
2.44

2170
2170

3798

SEQ ID
COMP ID
GGGGGGCGAGAGGGTTGG

7545
7562
SEQ ID
CCAACCCTCTCGCCCCCC
2.34

2171
2171

3799

SEQ ID
COMP ID
GAGGGGGGCGAGAGGGTT

7547
7564
SEQ ID
AACCCTCTCGCCCCCCTC
2.15

2172
2172

3800

SEQ ID
COMP ID
CAGAGGGGGGCGAGAGGG

7549
7566
SEQ ID
CCCTCTCGCCCCCCTCTG
2.09

2173
2173

3801

SEQ ID
COMP ID
GTCAGAGGGGGGCGAGAG

7551
7568
SEQ ID
CTCTCGCCCCCCTCTGAC
2.16

2174
2174

3802

SEQ ID
COMP ID
TGGTCAGAGGGGGGCGAG

7553
7570
SEQ ID
CTCGCCCCCCTCTGACCA
2.56

2175
2175

3803

SEQ ID
COMP ID
GATGGTCAGAGGGGGGCG

7555
7572
SEQ ID
CGCCCCCCTCTGACCATC
2.36

2176
2176

3804

SEQ ID
COMP ID
TGGATGGTCAGAGGGGGG

7557
7574
SEQ ID
CCCCCCTCTGACCATCCA
2.84

2177
2177

3805

SEQ ID
COMP ID
ATCAGCACAACAGACGCC
1901
1918
7576
7593
SEQ ID
GGCGTCTGTTGTGCTGAT
1.13

2178
2178

3806

SEQ ID
COMP ID
CGATCAGCACAACAGACG
1903
1920
7578
7595
SEQ ID
CGTCTGTTGTGCTGATCG
1.26

2179
2179

3807

SEQ ID
COMP ID
GCCGATCAGCACAACAGA
1905
1922
7580
7597
SEQ ID
TCTGTTGTGCTGATCGGC
1.43

2180
2180

3808

SEQ ID
COMP ID
GCGCCGATCAGCACAACA
1907
1924
7582
7599
SEQ ID
TGTTGTGCTGATCGGCGC
1.83

2181
2181

3809

SEQ ID
COMP ID
TGGCGCCGATCAGCACAA
1909
1926
7584
7601
SEQ ID
TTGTGCTGATCGGCGCCA
1.59

2182
2182

3810

SEQ ID
COMP ID
AGTGGCGCCGATCAGCAC
1911
1928
7586
7603
SEQ ID
GTGCTGATCGGCGCCACT
1.86

2183
2183

3811

SEQ ID
COMP ID
GCAGTGGCGCCGATCAGC
1913
1930
7588
7605
SEQ ID
GCTGATCGGCGCCACTGC
1.73

2184
2184

3812

SEQ ID
COMP ID
CAGCAGTGGCGCCGATCA
1915
1932
7590
7607
SEQ ID
TGATCGGCGCCACTGCTG
1.63

2185
2185

3813

SEQ ID
COMP ID
GACAGCAGTGGCGCCGAT
1917
1934
7592
7609
SEQ ID
ATCGGCGCCACTGCTGTC
1.67

2186
2186

3814

SEQ ID
COMP ID
AGGACAGCAGTGGCGCCG
1919
1936
7594
7611
SEQ ID
CGGCGCCACTGCTGTCCT
1.63

2187
2187

3815

SEQ ID
COMP ID
GCAGGACAGCAGTGGCGC
1921
1938
7596
7613
SEQ ID
GCGCCACTGCTGTCCTGC
1.39

2188
2188

3816

SEQ ID
COMP ID
CAGCAGGACAGCAGTGGC
1923
1940
7598
7615
SEQ ID
GCCACTGCTGTCCTGCTG
1.3

2189
2189

3817

SEQ ID
COMP ID
GCCAGCAGGACAGCAGTG
1925
1942
7600
7617
SEQ ID
CACTGCTGTCCTGCTGGC
1.38

2190
2190

3818

SEQ ID
COMP ID
AAGCCAGCAGGACAGCAG
1927
1944
7602
7619
SEQ ID
CTGCTGTCCTGCTGGCTT
1.44

2191
2191

3819

SEQ ID
COMP ID
GGAAGCCAGCAGGACAGC
1929
1946
7604
7621
SEQ ID
GCTGTCCTGCTGGCTTCC
1.23

2192
2192

3820

SEQ ID
COMP ID
GCGGAAGCCAGCAGGACA
1931
1948
7606
7623
SEQ ID
TGTCCTGCTGGCTTCCGC
1.52

2193
2193

3821

SEQ ID
COMP ID
CAGCGGAAGCCAGCAGGA
1933
1950
7608
7625
SEQ ID
TCCTGCTGGCTTCCGCTG
1.84

2194
2194

3822

SEQ ID
COMP ID
CGCAGCGGAAGCCAGCAG
1935
1952
7610
7627
SEQ ID
CTGCTGGCTTCCGCTGCG
1.59

2195
2195

3823

SEQ ID
COMP ID
TGCGCAGCGGAAGCCAGC
1937
1954
7612
7629
SEQ ID
GCTGGCTTCCGCTGCGCA
2.07

2196
2196

3824

SEQ ID
COMP ID
GCTGCGCAGCGGAAGCCA
1939
1956
7614
7631
SEQ ID
TGGCTTCCGCTGCGCAGC
1.6

2197
2197

3825

SEQ ID
COMP ID
TGGCTGCGCAGCGGAAGC
1941
1958
7616
7633
SEQ ID
GCTTCCGCTGCGCAGCCA
1.6

2198
2198

3826

SEQ ID
COMP ID
CCTGGCTGCGCAGCGGAA
1943
1960
7618
7635
SEQ ID
TTCCGCTGCGCAGCCAGG
1.74

2199
2199

3827

SEQ ID
COMP ID
CCCCTGGCTGCGCAGCGG
1945
1962
7620
7637
SEQ ID
CCGCTGCGCAGCCAGGGG
1.63

2200
2200

3828

SEQ ID
COMP ID
TACCCCTGGCTGCGCAGC
1947
1964
7622
7639
SEQ ID
GCTGCGCAGCCAGGGGTA
1.39

2201
2201

3829

SEQ ID
COMP ID
GGTACCCCTGGCTGCGCA
1949
1966
7624
7641
SEQ ID
TGCGCAGCCAGGGGTACC
2.25

2202
2202

3830

SEQ ID
COMP ID
TTGGTACCCCTGGCTGCG
1951
1968
7626
7643
SEQ ID
CGCAGCCAGGGGTACCAA
2.09

2203
2203

3831

SEQ ID
COMP ID
ACTTGGTACCCCTGGCTG
1953
1970
7628
7645
SEQ ID
CAGCCAGGGGTACCAAGT
1.69

2204
2204

3832

SEQ ID
COMP ID
ACACTTGGTACCCCTGGC
1955
1972
7630
7647
SEQ ID
GCCAGGGGTACCAAGTGT
1.39

2205
2205

3833

SEQ ID
COMP ID
AAACACTTGGTACCCCTG
1957
1974
7632
7649
SEQ ID
CAGGGGTACCAAGTGTTT
1.63

2206
2206

3834

SEQ ID
COMP ID
GCAAACACTTGGTACCCC
1959
1976
7634
7651
SEQ ID
GGGGTACCAAGTGTTTGC
1.44

2207
2207

3835

SEQ ID
COMP ID
GCGCAAACACTTGGTACC
1961
1978
7636
7653
SEQ ID
GGTACCAAGTGTTTGCGC
1.81

2208
2208

3836

SEQ ID
COMP ID
CTGCGCAAACACTTGGTA
1963
1980
7638
7655
SEQ ID
TACCAAGTGTTTGCGCAG
2.34

2209
2209

3837

SEQ ID
COMP ID
CCCTGCGCAAACACTTGG
1965
1982
7640
7657
SEQ ID
CCAAGTGTTTGCGCAGGG
1.63

2210
2210

3838

SEQ ID
COMP ID
CTCCCTGCGCAAACACTT
1967
1984
7642
7659
SEQ ID
AAGTGTTTGCGCAGGGAG
1.61

2211
2211

3839

SEQ ID
COMP ID
GCCTCCCTGCGCAAACAC
1969
1986
7644
7661
SEQ ID
GTGTTTGCGCAGGGAGGC
1.57

2212
2212

3840

SEQ ID
COMP ID
GGGCCTCCCTGCGCAAAC
1971
1988
7646
7663
SEQ ID
GTTTGCGCAGGGAGGCCC
2.01

2213
2213

3841

SEQ ID
COMP ID
CGGGGCCTCCCTGCGCAA
1973
1990
7648
7665
SEQ ID
TTGCGCAGGGAGGCCCCG
2.03

2214
2214

3842

SEQ ID
COMP ID
CGCGGGGCCTCCCTGCGC
1975
1992
7650
7667
SEQ ID
GCGCAGGGAGGCCCCGCG
0.96

2215
2215

3843

SEQ ID
COMP ID
AGCGCGGGGCCTCCCTGC
1977
1994
7652
7669
SEQ ID
GCAGGGAGGCCCCGCGCT
1.5

2216
2216

3844

SEQ ID
COMP ID
CCAGCGCGGGGCCTCCCT
1979
1996
7654
7671
SEQ ID
AGGGAGGCCCCGCGCTGG
no data

2217
2217

3845

SEQ ID
COMP ID
TCCCAGCGCGGGGCCTCC
1981
1998
7656
7673
SEQ ID
GGAGGCCCCGCGCTGGGA
no data

2218
2218

3846

SEQ ID
COMP ID
CGTCCCAGCGCGGGGCCT
1983
2000
7658
7675
SEQ ID
AGGCCCCGCGCTGGGACG
no data

2219
2219

3847

SEQ ID
COMP ID
GGCGTCCCAGCGCGGGGC
1985
2002
7660
7677
SEQ ID
GCCCCGCGCTGGGACGCC
1.39

2220
2220

3848

SEQ ID
COMP ID
GGGGCGTCCCAGCGCGGG
1987
2004
7662
7679
SEQ ID
CCCGCGCTGGGACGCCCC
no data

2221
2221

3849

SEQ ID
COMP ID
AAGGGGCGTCCCAGCGCG
1989
2006
7664
7681
SEQ ID
CGCGCTGGGACGCCCCTT
1.86

2222
2222

3850

SEQ ID
COMP ID
CAAAGGGGCGTCCCAGCG
1991
2008
7666
7683
SEQ ID
CGCTGGGACGCCCCTTTG
1.34

2223
2223

3851

SEQ ID
COMP ID
CTCAAAGGGGCGTCCCAG
1993
2010
7668
7685
SEQ ID
CTGGGACGCCCCTTTGAG
1.51

2224
2224

3852

SEQ ID
COMP ID
CCCTCAAAGGGGCGTCCC
1995
2012
7670
7687
SEQ ID
GGGACGCCCCTTTGAGGG
1.36

2225
2225

3853

SEQ ID
COMP ID
GTCCCTCAAAGGGGCGTC
1997
2014
7672
7689
SEQ ID
GACGCCCCTTTGAGGGAC
no data

2226
2226

3854

SEQ ID
COMP ID
GGGTCCCTCAAAGGGGCG
1999
2016
7674
7691
SEQ ID
CGCCCCTTTGAGGGACCC
no data

2227
2227

3855

SEQ ID
COMP ID
CTGGGTCCCTCAAAGGGG
2001
2018
7676
7693
SEQ ID
CCCCTTTGAGGGACCCAG
no data

2228
2228

3856

SEQ ID
COMP ID
GGCTGGGTCCCTCAAAGG
2003
2020
7678
7695
SEQ ID
CCTTTGAGGGACCCAGCC
no data

2229
2229

3857

SEQ ID
COMP ID
AAGGCTGGGTCCCTCAAA
2005
2022
7680
7697
SEQ ID
TTTGAGGGACCCAGCCTT
no data

2230
2230

3858

SEQ ID
COMP ID
TCAAGGCTGGGTCCCTCA
2007
2024
7682
7699
SEQ ID
TGAGGGACCCAGCCTTGA
no data

2231
2231

3859

SEQ ID
COMP ID
TCTCAAGGCTGGGTCCCT
2009
2026
7684
7701
SEQ ID
AGGGACCCAGCCTTGAGA
no data

2232
2232

3860

SEQ ID
COMP ID
TGTCTCAAGGCTGGGTCC
2011
2028
7686
7703
SEQ ID
GGACCCAGCCTTGAGACA
no data

2233
2233

3861

SEQ ID
COMP ID
GCTGTCTCAAGGCTGGGT
2013
2030
7688
7705
SEQ ID
ACCCAGCCTTGAGACAGC
no data

2234
2234

3862

SEQ ID
COMP ID
CAGCTGTCTCAAGGCTGG
2015
2032
7690
7707
SEQ ID
CCAGCCTTGAGACAGCTG
no data

2235
2235

3863

SEQ ID
COMP ID
AGCAGCTGTCTCAAGGCT
2017
2034
7692
7709
SEQ ID
AGCCTTGAGACAGCTGCT
no data

2236
2236

3864

SEQ ID
COMP ID
ACAGCAGCTGTCTCAAGG
2019
2036
7694
7711
SEQ ID
CCTTGAGACAGCTGCTGT
no data

2237
2237

3865

SEQ ID
COMP ID
TCACAGCAGCTGTCTCAA
2021
2038
7696
7713
SEQ ID
TTGAGACAGCTGCTGTGA
no data

2238
2238

3866

SEQ ID
COMP ID
GCCTGCGTCCGACTCCGC
234
251

SEQ ID
GCGGAGTCGGACGCAGGC
1.58

2239
2239

3867

SEQ ID
COMP ID
CTGCCTGCGTCCGACTCC
236
253

SEQ ID
GGAGTCGGACGCAGGCAG
1.56

2240
2240

3868

SEQ ID
COMP ID
GTCTGCCTGCGTCCGACT
238
255

SEQ ID
AGTCGGACGCAGGCAGAC
1.39

2241
2241

3869

SEQ ID
COMP ID
TGGTCTGCCTGCGTCCGA
240
257

SEQ ID
TCGGACGCAGGCAGACCA
1.74

2242
2242

3870

SEQ ID
COMP ID
CATGGTCTGCCTGCGTCC
242
259

SEQ ID
GGACGCAGGCAGACCATG
1.89

2243
2243

3871

SEQ ID
COMP ID
CACATGGTCTGCCTGCGT
244
261

SEQ ID
ACGCAGGCAGACCATGTG
1.91

2244
2244

3872

SEQ ID
COMP ID
TCCAGAAGGGGACGGCAG
379
396

SEQ ID
CTGCCGTCCCCTTCTGGA
1.82

2245
2245

3873

SEQ ID
COMP ID
TGTCCAGAAGGGGACGGC
381
398

SEQ ID
GCCGTCCCCTTCTGGACA
1.57

2246
2246

3874

SEQ ID
COMP ID
TTTGTCCAGAAGGGGACG
383
400

SEQ ID
CGTCCCCTTCTGGACAAA
1.55

2247
2247

3875

SEQ ID
COMP ID
CATTTGTCCAGAAGGGGA
385
402

SEQ ID
TCCCCTTCTGGACAAATG
2.73

2248
2248

3876

SEQ ID
COMP ID
GCCATTTGTCCAGAAGGG
387
404

SEQ ID
CCCTTCTGGACAAATGGC
1.49

2249
2249

3877

SEQ ID
COMP ID
GGGCCATTTGTCCAGAAG
389
406

SEQ ID
CTTCTGGACAAATGGCCC
1.37

2250
2250

3878

SEQ ID
COMP ID
GTGGGCCATTTGTCCAGA
391
408

SEQ ID
TCTGGACAAATGGCCCAC
1.51

2251
2251

3879

SEQ ID
COMP ID
TTGTGGGCCATTTGTCCA
393
410

SEQ ID
TGGACAAATGGCCCACAA
1.59

2252
2252

3880

SEQ ID
COMP ID
GGCCTCTGGGAAGGGGCA
506
523

SEQ ID
TGCCCCTTCCCAGAGGCC
2.34

2253
2253

3881

SEQ ID
COMP ID
ACGGCCTCTGGGAAGGGG
508
525

SEQ ID
CCCCTTCCCAGAGGCCGT
3.92

2254
2254

3882

SEQ ID
COMP ID
CCACGGCCTCTGGGAAGG
510
527

SEQ ID
CCTTCCCAGAGGCCGTGG
1.88

2255
2255

3883

SEQ ID
COMP ID
TGCCACGGCCTCTGGGAA
512
529

SEQ ID
TTCCCAGAGGCCGTGGCA
2.05

2256
2256

3884

SEQ ID
COMP ID
CATGCCACGGCCTCTGGG
514
531

SEQ ID
CCCAGAGGCCGTGGCATG
2.05

2257
2257

3885

SEQ ID
COMP ID
CGCATGCCACGGCCTCTG
516
533

SEQ ID
CAGAGGCCGTGGCATGCG
2.33

2258
2258

3886

SEQ ID
COMP ID
CCCGCATGCCACGGCCTC
518
535

SEQ ID
GAGGCCGTGGCATGCGGG
2.29

2259
2259

3887

SEQ ID
COMP ID
TTACCTGATCTTTGGAAG
592
609

SEQ ID
CTTCCAAAGATCAGGTAA
1.69

2260
2260

3888

SEQ ID
COMP ID
TGTTACCTGATCTTTGGA
594
611

SEQ ID
TCCAAAGATCAGGTAACA
1.76

2261
2261

3889

SEQ ID
COMP ID
GTTGTTACCTGATCTTTG
596
613

SEQ ID
CAAAGATCAGGTAACAAC
2.04

2262
2262

3890

SEQ ID
COMP ID
GAGTTGTTACCTGATCTT
598
615

SEQ ID
AAGATCAGGTAACAACTC
1.93

2263
2263

3891

SEQ ID
COMP ID
CGGAGTTGTTACCTGATC
600
617

SEQ ID
GATCAGGTAACAACTCCG
1.6

2264
2264

3892

SEQ ID
COMP ID
CACGGAGTTGTTACCTGA
602
619

SEQ ID
TCAGGTAACAACTCCGTG
1.88

2265
2265

3893

SEQ ID
COMP ID
AGCCTGGGGCATGGGGCA
704
721

SEQ ID
TGCCCCATGCCCCAGGCT
3.73

2266
2266

3894

SEQ ID
COMP ID
GAAGCCTGGGGCATGGGG
706
723

SEQ ID
CCCCATGCCCCAGGCTTC
4.09

2267
2267

3895

SEQ ID
COMP ID
AGGAAGCCTGGGGCATGG
708
725

SEQ ID
CCATGCCCCAGGCTTCCT
1.56

2268
2268

3896

SEQ ID
COMP ID
GCAGGAAGCCTGGGGCAT
710
727

SEQ ID
ATGCCCCAGGCTTCCTGC
1.61

2269
2269

3897

SEQ ID
COMP ID
CAGCAGGAAGCCTGGGGC
712
729

SEQ ID
GCCCCAGGCTTCCTGCTG
1.41

2270
2270

3898

SEQ ID
COMP ID
CACAGCAGGAAGCCTGGG
714
731

SEQ ID
CCCAGGCTTCCTGCTGTG
1.21

2271
2271

3899

SEQ ID
COMP ID
ACTGCCCTGTTAGTCCTC
838
855

SEQ ID
GAGGACTAACAGGGCAGT
1.29

2272
2272

3900

SEQ ID
COMP ID
CCACTGCCCTGTTAGTCC
840
857

SEQ ID
GGACTAACAGGGCAGTGG
1.12

2273
2273

3901

SEQ ID
COMP ID
GGCCACTGCCCTGTTAGT
842
859

SEQ ID
ACTAACAGGGCAGTGGCC
1.46

2274
2274

3902

SEQ ID
COMP ID
AAGGCCACTGCCCTGTTA
844
861

SEQ ID
TAACAGGGCAGTGGCCTT
1.37

2275
2275

3903

SEQ ID
COMP ID
ACAAGGCCACTGCCCTGT
846
863

SEQ ID
ACAGGGCAGTGGCCTTGT
1.19

2276
2276

3904

SEQ ID
COMP ID
GGACAAGGCCACTGCCCT
848
865

SEQ ID
AGGGCAGTGGCCTTGTCC
1.48

2277
2277

3905

SEQ ID
COMP ID
CTGGACAAGGCCACTGCC
850
867

SEQ ID
GGCAGTGGCCTTGTCCAG
1.48

2278
2278

3906

SEQ ID
COMP ID
GCGTTGGGCATTGGGCAG
949
966

SEQ ID
CTGCCCAATGCCCAACGC
1.39

2279
2279

3907

SEQ ID
COMP ID
TGGCGTTGGGCATTGGGC
951
968

SEQ ID
GCCCAATGCCCAACGCCA
2.29

2280
2280

3908

SEQ ID
COMP ID
GGTGGCGTTGGGCATTGG
953
970

SEQ ID
CCAATGCCCAACGCCACC
1.54

2281
2281

3909

SEQ ID
COMP ID
CAGGTGGCGTTGGGCATT
955
972

SEQ ID
AATGCCCAACGCCACCTG
1.69

2282
2282

3910

SEQ ID
COMP ID
AGCAGGTGGCGTTGGGCA
957
974

SEQ ID
TGCCCAACGCCACCTGCT
1.53

2283
2283

3911

SEQ ID
COMP ID
GCAGCAGGTGGCGTTGGG
959
976

SEQ ID
CCCAACGCCACCTGCTGC
1.85

2284
2284

3912

SEQ ID
COMP ID
GAGCAGCAGGTGGCGTTG
961
978

SEQ ID
CAACGCCACCTGCTGCTC
1.64

2285
2285

3913

SEQ ID
COMP ID
CGGAGCAGCAGGTGGCGT
963
980

SEQ ID
ACGCCACCTGCTGCTCCG
1.15

2286
2286

3914

SEQ ID
COMP ID
ACTGTGTGCGCAGGCAGC
1075
1092

SEQ ID
GCTGCCTGCGCACACAGT
1.15

2287
2287

3915

SEQ ID
COMP ID
CCACTGTGTGCGCAGGCA
1077
1094

SEQ ID
TGCCTGCGCACACAGTGG
1.33

2288
2288

3916

SEQ ID
COMP ID
CCCCACTGTGTGCGCAGG
1079
1096

SEQ ID
CCTGCGCACACAGTGGGG
1.19

2289
2289

3917

SEQ ID
COMP ID
TCCCCCACTGTGTGCGCA
1081
1098

SEQ ID
TGCGCACACAGTGGGGGA
1.41

2290
2290

3918

SEQ ID
COMP ID
CATCCCCCACTGTGTGCG
1083
1100

SEQ ID
CGCACACAGTGGGGGATG
1.25

2291
2291

3919

SEQ ID
COMP ID
CACATCCCCCACTGTGTG
1085
1102

SEQ ID
CACACAGTGGGGGATGTG
1.15

2292
2292

3920

SEQ ID
COMP ID
GCCTGGGTAAAAGGGCAG
1174
1191

SEQ ID
CTGCCCTTTTACCCAGGC
1.3

2293
2293

3921

SEQ ID
COMP ID
CAGCCTGGGTAAAAGGGC
1176
1193

SEQ ID
GCCCTTTTACCCAGGCTG
1.73

2294
2294

3922

SEQ ID
COMP ID
CACAGCCTGGGTAAAAGG
1178
1195

SEQ ID
CCTTTTACCCAGGCTGTG
1.74

2295
2295

3923

SEQ ID
COMP ID
CACACAGCCTGGGTAAAA
1180
1197

SEQ ID
TTTTACCCAGGCTGTGTG
1.19

2296
2296

3924

SEQ ID
COMP ID
AGCACACAGCCTGGGTAA
1182
1199

SEQ ID
TTACCCAGGCTGTGTGCT
1.16

2297
2297

3925

SEQ ID
COMP ID
ACAGCACACAGCCTGGGT
1184
1201

SEQ ID
ACCCAGGCTGTGTGCTGT
1.18

2298
2298

3926

SEQ ID
COMP ID
TCACAGCACACAGCCTGG
1186
1203

SEQ ID
CCAGGCTGTGTGCTGTGA
1.12

2299
2299

3927

SEQ ID
COMP ID
GCCTCTGGGATTGGACAG
1420
1437

SEQ ID
CTGTCCAATCCCAGAGGC
1.49

2300
2300

3928

SEQ ID
COMP ID
CAGCCTCTGGGATTGGAC
1422
1439

SEQ ID
GTCCAATCCCAGAGGCTG
1.24

2301
2301

3929

SEQ ID
COMP ID
GACAGCCTCTGGGATTGG
1424
1441

SEQ ID
CCAATCCCAGAGGCTGTC
1.69

2302
2302

3930

SEQ ID
COMP ID
CAGACAGCCTCTGGGATT
1426
1443

SEQ ID
AATCCCAGAGGCTGTCTG
1.27

2303
2303

3931

SEQ ID
COMP ID
AGCAGACAGCCTCTGGGA
1428
1445

SEQ ID
TCCCAGAGGCTGTCTGCT
1.21

2304
2304

3932

SEQ ID
COMP ID
GCAGCAGACAGCCTCTGG
1430
1447

SEQ ID
CCAGAGGCTGTCTGCTGC
1.19

2305
2305

3933

SEQ ID
COMP ID
GAGCAGCAGACAGCCTCT
1432
1449

SEQ ID
AGAGGCTGTCTGCTGCTC
1.33

2306
2306

3934

SEQ ID
COMP ID
GCATGGGGCAACTGGCAG
1654
1671

SEQ ID
CTGCCAGTTGCCCCATGC
1.73

2307
2307

3935

SEQ ID
COMP ID
CAGCATGGGGCAACTGGC
1656
1673

SEQ ID
GCCAGTTGCCCCATGCTG
2.47

2308
2308

3936

SEQ ID
COMP ID
CACAGCATGGGGCAACTG
1658
1675

SEQ ID
CAGTTGCCCCATGCTGTG
2.03

2309
2309

3937

SEQ ID
COMP ID
CACACAGCATGGGGCAAC
1660
1677

SEQ ID
GTTGCCCCATGTGTGTG
1.74

2310
2310

3938

SEQ ID
COMP ID
AGCACACAGCATGGGGCA
1662
1679

SEQ ID
TGCCCCATGCTGTGTGCT
2.02

2311
2311

3939

SEQ ID
COMP ID
GCAGCACACAGCATGGGG
1664
1681

SEQ ID
CCCCATGCTGTGTGCTGC
2.29

2312
2312

3940

SEQ ID
COMP ID
TCGCAGCACACAGCATGG
1666
1683

SEQ ID
CCATGCTGTGTGCTGCGA
1.4

2313
2313

3941

SEQ ID
COMP ID
CCTCGCAGCACACAGCAT
1668
1685

SEQ ID
ATGCTGTGTGCTGCGAGG
1.31

2314
2314

3942

SEQ ID
COMP ID
CCCTGGCGGTAGGGACAG
1885
1902

SEQ ID
CTGTCCCTACCGCCAGGG
1.34

2315
2315

3943

SEQ ID
COMP ID
CGCCCTGGCGGTAGGGAC
1887
1904

SEQ ID
GTCCCTACCGCCAGGGCG
1.56

2316
2316

3944

SEQ ID
COMP ID
GACGCCCTGGCGGTAGGG
1889
1906

SEQ ID
CCCTACCGCCAGGGCGTC
4.23

2317
2317

3945

SEQ ID
COMP ID
CAGACGCCCTGGCGGTAG
1891
1908

SEQ ID
CTACCGCCAGGGCGTCTG
3.09

2318
2318

3946

SEQ ID
COMP ID
AACAGACGCCCTGGCGGT
1893
1910

SEQ ID
ACCGCCAGGGCGTCTGTT
1.85

2319
2319

3947

SEQ ID
COMP ID
ACAACAGACGCCCTGGCG
1895
1912

SEQ ID
CGCCAGGGCGTCTGTTGT
1.61

2320
2320

3948

SEQ ID
HELM, 5′ - 3′ direction

SEQ ID 3
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 4
[LR]([5meC])[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 5
[LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 6
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 7
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 8
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 9
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 10
[LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 11
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 12
[LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 13
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 14
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 15
[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 16
[LR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 17
[LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 18
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 19
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 20
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 21
[LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR([5meC])[sP] · [LR]([5meC]

SEQ ID 22
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC]

SEQ ID 23
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 24
[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 25
[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 26
[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 27
[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 28
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 29
[LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 30
[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 31
[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 32
[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 33
[LR](T)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR(T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 34
[LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 35
[LR](T)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 36
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 37
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 38
[LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 39
[LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 40
[LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 41
[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 42
[LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 43
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 44
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 45
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 46
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 47
[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 48
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 49
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](G)[P] · [dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 50
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 51
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 52
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 53
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 54
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[P] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 55
[LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 56
[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 57
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 58
[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 59
[LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 60
[LR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 61
[LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 62
[LR](T)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 63
[LR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 64
[LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 65
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 66
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 67
[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 68
[LR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 69
[LR](T)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 70
[LR]([5meC])[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 71
[LR](A)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 72
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [LR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 73
[LR]([5meC])[sP] · [LR](T)[sP] · [LR](A)[P] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 74
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 75
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 76
[LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 77
[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 78
[LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 79
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[P] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 80
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 81
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 82
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 83
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 84
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 85
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 86
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 87
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC]) · [LR](T)

SEQ ID 88
[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC])

SEQ ID 89
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 90
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC]) ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 91
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 92
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 93
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 94
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 95
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 96
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 97
[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 98
[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 99
[LR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 100
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 101
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 102
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 103
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 104
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 105
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 106
[LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 107
[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 108
[LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 109
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 110
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 111
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 112
[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 113
[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP]

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 114
[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 115
[LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 116
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A

SEQ ID 117
[LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 118
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 119
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 120
[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 121
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 122
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 123
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 124
[LR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 125
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[dR](A)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 126
[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 127
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 128
[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 129
[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR]([5meC])[sP] ·

[dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 130
[LR](T)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](A)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 131
[LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 132
[LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 133
[LR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 134
[LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 135
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 136
[LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 137
[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 138
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 139
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 140
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 141
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 142
[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 143
[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 144
[LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 145
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](C)[sP] · [LR](T)

SEQ ID 146
[LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 147
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 148
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 149
[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 150
[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 151
[LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 152
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 153
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 154
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 155
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 156
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 157
[LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

A[LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 158
[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[P] · [LR](G)

SEQ ID 159
[LR](T)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])sP] · [LR](A)

SEQ ID 160
[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 161
[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 162
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 163
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 164
[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 165
[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 166
[LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 167
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](A)[P] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC])

SEQ ID 168
[LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR]

[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 169
[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 170
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 171
[LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 172
[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](GC)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 173
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](C)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 174
[LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 175
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 176
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 177
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 178
[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 179
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 180
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 181
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 182
[LR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 183
[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 184
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 185
[LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[P] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 186
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 187
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](A

SEQ ID 188
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 189
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 190
[LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR]([5meC])[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 191
[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 192
[LR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 193
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 194
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](5meC]

SEQ ID 195
[LR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 196
[LR]([5meC])[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 197
[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 198
[LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 199
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 200
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 201
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 202
[LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 203
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 204
[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 205
[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 206
[LR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 207
[LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 208
[LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 209
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP]

SEQ ID 210
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC])

SEQ ID 211
[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 212
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 213
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 214
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 215
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC][sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 216
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 217
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 218
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 219
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC])

SEQ ID 220
[LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 221
[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR][(5meC]

SEQ ID 222
[LR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[P] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 223
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR][(5meC]

SEQ ID 224
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 225
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 226
[LR]([5meC])[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 227
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 228
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 229
[LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 230
[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 231
[LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 232
[LR]([5meC])[sP] · [dR](A)[P] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 233
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 234
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 235
[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 236
[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 237
[LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 238
[LR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 239
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 240
[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 241
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 242
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 243
[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 244
[LR](T)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 245
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 246
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](C)[P] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[P] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 247
[LR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 248
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 249
[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 250
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 251
[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 252
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 253
[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 254
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 255
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 256
[LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 257
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 258
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 259
[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 260
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 261
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 262
[LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 263
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 264
[LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 265
[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 266
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 267
[LR](T)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 268
[LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 269
[LR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 270
[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 271
[LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 272
[LR]([5meC])[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 273
[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](T)

SEQ ID 274
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G) [sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 275
[LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 276
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 277
[LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G

SEQ ID 278
[LR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 279
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 280
[LR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 281
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 282
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 283
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 284
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 285
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 286
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 287
[LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 288
[LR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR]([5meC]

SEQ ID 289
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 290
[LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 291
[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](A)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 292
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LRP(T)[sP] ·

[dR](A)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 293
[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 294
[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 295
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 296
[LR]([5meC])[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 297
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](C)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 298
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 299
[LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 300
[LR]([5meC])[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 301
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[dR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 302
[LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 303
[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 304
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](A)[sP] ·

[dR](A)[sP] · [LR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 305
[LR]([5meC])[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 306
[LR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T))[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 307
[LR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 308
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](A)

SEQ ID 309
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 310
[LR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] ·

[dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 311
[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 312
[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)

SEQ ID 313
[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR]([5meC]) · [dR](G)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)

SEQ ID 314
[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 315
[LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[dR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 316
[LR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 317
[LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] ·

[LR](T)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 318
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](T)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 319
[LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 320
[LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](G)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 321
[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP]

[dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR]([5meC]

SEQ ID 322
[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](A)[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 323
[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](G)[sP] · [LR](A)[sP] · [LR](T)[sP] ·

[dR](A)[sP] · [LR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR]([A)[sP] · [LR]([5meC]

SEQ ID 324
[LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](T)[sP] · [dR](A)[sP] · [dR](G)[sP] · [LR](G)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](G)

SEQ ID 325
[LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](G)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 326
[LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] ·

[dR](C)[sP] · [dR](C)[sP] · [dR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] ·

[dR](G)[sP] · [LR](A)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](G)

SEQ ID 327
[LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [dR](C)[sP] · [dR](T)[sP] ·

[LR](G)[sP] · [dR](T)[sP] · [dR](G)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](T)

SEQ ID 328
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] ·

[dR](C)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](G)

SEQ ID 329
[LR](A)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](C)[sP] · [dR](C)[sP] · [LR]([5meC])[sP] · [LR](T)

SEQ ID 330
[LR]([5meC])[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] ·[LR]([5meC]

SEQ ID 331
[LR](A)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 332
[LR]([5meC])[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] ·

[dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR](A)

SEQ ID 333
[LR](A)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[dR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 334
[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] ·

[dR](C)[sP] · [dR](A)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR]([5meC])[sP] · [dR](G)[sP] ·

[dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR]([5meC]) · [LR](A)

SEQ ID 335
[LR](A)[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](G)[sP] · [LR](A)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [dR](C)[sP] · [LR](A)[sP] · [dR](C)[sP] ·

[LR](A)[sP] · [dR](C)[sP] · [LR](G)[sP] · [dR](C)[sP] · [LR](G)[sP] · [LR]([5meC]

SEQ ID 336
[LR](T)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[LR](G)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] ·

[LR]([5meC])[sP] · [LR](A)[sP] · [dR](C)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 337
[LR](A)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [dR](T)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] ·

[LR](A)[sP] · [LR]([5meC])[sP] · [dR](G)[sP] · [LR]([5meC])[sP] · [LR](A)[sP] · [LR]([5meC]

SEQ ID 338
[LR](A)[sP] · [LR]([5meC])[sP] · [LR](A)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](A)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[LR](G)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR](G)

SEQ ID 339
[LR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] ·

[LR](A)[sP] · [LR](T)[sP] · [dR](T)[sP] · [LR](G)[sP] · [LR](A)[sP] · [LR](A)

SEQ ID 340
[LR](A)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](T)[sP] · [LR](G)[sP] · [dR](T)[sP] ·

[LR](A)[sP] · [LR]([5meC])[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR]([5meC])[sP] ·

[LR](T)[sP] · [dR](T)[sP] · [LR](T)[sP] · [dR](A)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 341
[LR](A)[sP] · [LR](G)[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR](G)[sP] ·

[LR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] · [LR](A)[sP] · [LR]([5meC][sP] · [dR](A)[sP] ·

[LR](A)[sP] · [dR](A)[sP] · [LR]([5meC])[sP] · [dR](T)[sP] · [LR](T)[sP] · [LR](T)

SEQ ID 342
[LR](T)[sP] · [LR](T)[sP] · [LR](A)[sP] · [dR](A)[sP] · [LR](G)[sP] · [LR](A)[sP] ·

[dR](A)[sP] · [LR](A)[sP] · [LR](G)[sP] · [LR](T)[sP] · [dR](G)[sP] · [LR](T)[sP] ·

[LR](A)[sP] · [LR]([5meC])[sP] · [dR](A)[sP] · [dR](A)[sP] · [LR](A)[sP] · [LR]([5meC]

Helm Annotation Key:

[LR](G) is a beta-D-oxy-LNA guanine nucleoside,

[LR](T) is a beta-D-oxy-LNA thymine nucleoside,

[LR](A) is a beta-D-oxy-LNA adenine nucleoside,

[LR]([5meC] is a beta-D-oxy-LNA 5-methyl cystosine nucleoside,

[dR](G) is a DNA guanine nucleoside,

[dR](T) is a DNA thymine nucleoside,

[dR](A) is a DNA adenine nucleoside,

[dR]([C] is a DNA cytosine nucleoside,

[mR](G) is a 2′-O-methyl RNA guanine nucleoside,

[mR](U) is a 2′-O-methyl RNA DNA uracil nucleoside,

[mR](A) is a 2′-O-methyl RNA DNA adenine nucleoside,

[mR]([C] is a 2′-O-methyl RNA DNA cytosine nucleoside,

[sP] is a phosphorothioate internucleoside linkage.

Number	Name	Date	Kind
6824775	Serrero	Nov 2004	B2
7250496	Bentwich	Jul 2007	B2
7655785	Bentwich	Feb 2010	B1
8090542	Khvorova	Jan 2012	B2
9486541	Hutton	Nov 2016	B2
10323236	Liu	Jun 2019	B2
20050014711	Nyce	Jan 2005	A1
20070238687	Bhanot	Oct 2007	A1
20150232836	Krieg	Aug 2015	A1
20180087104	Joung	Mar 2018	A1
20220204973	Jagasia et al.	Jun 2022	A1

Number	Date	Country
202208628	Mar 2022	TW
9839352	Sep 1998	WO
9914226	Mar 1999	WO
2000047599	Aug 2000	WO
0066604	Nov 2000	WO
0123613	Apr 2001	WO
2004016160	Feb 2004	WO
2004046160	Jun 2004	WO
2007090071	Aug 2007	WO
2007134181	Nov 2007	WO
2008150729	Dec 2008	WO
2008154401	Dec 2008	WO
2009006478	Jan 2009	WO
2009067647	May 2009	WO
2010036698	Apr 2010	WO
2010077578	Jul 2010	WO
2011017521	Feb 2011	WO
2011156202	Dec 2011	WO
2013154798	Oct 2013	WO
2013173635	Nov 2013	WO
2014076195	May 2014	WO
2015113922	Aug 2015	WO
2016077837	May 2016	WO
2019001212	Jan 2019	WO
2019109051	Jun 2019	WO
2020077165	Apr 2020	WO
2020191212	Sep 2020	WO
2021229036	Nov 2021	WO

Oligonucleotide agonists targeting progranulin

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Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

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US

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Abstract

Description

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Priority Claims (2)

US Referenced Citations (11)

Foreign Referenced Citations (28)

Non-Patent Literature Citations (52)

Related Publications (1)

Entry
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