Adams, GP et al., "Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain FV.", Cancer Res. Sep. 1; 53(17):4026-34 (1993) (Exhibit 1). |
Huston, JS et al., "Antigen recognition and targeted delivery by the single-chain Fv"; Cell Biophys. Jan.-Jun.; 22(1-3):189-224 (1993) (Exhibit 2). |
Huston, JS, "Multisite association by recombinant proteins can enhance binding selectivity. Preferential removal of immune complexes from serum by immobilized truncated FB analogues of the B domain from staphylococcal protein A", Biophys. J. Apr.;62(1):87-91 (1992) (Exhibit 3). |
McCartney, JE et al., "Biosynthetic antibody binding sites; development of a single-chain Fv model based on antidinitrophenol IgA myeloma MOPC 315", J. Protein Chem. Dec;10(6):669-83 (1991) (Exhibit 4). |
Tai, MS et al., "A bifunctional fusion protein containing Fc-binding fragment B of staphylococcal protein A amino terminal to antidigoxin single-chain Fv" Biochemistry Sep. 4;29(35):8024-30 (1990) (Exhibit 5). |
Huston, JS et al., "Protein engineering of single-chain Fv analogs and fusion proteins", Methods Enzymol, 203:46-88 (1991) (Exhibit 10) Huston, JS et al., "Protein engineering of single-chain Fv analogs and fusion proteins", Methods Enzymol, 203:46-88 (1991) (Exhibit 6). |
Anderson et al., "Crosslinking of T3 (CD3) with T4 (CD4) Enhances the Proliferation of Resting T Lymphocytes", J. Immunol. 139:678-682 (1987) (Exhibit 1). |
Capon et al., "Designing CD4 Immunoadhesions for AIDS Therapy", Nature 337:525-531 (1989) (Exhbit 2). |
Chappel et al., "Identification of the Fc Receptor Class I Binding Site in Human IgG Through the Use of Recombinant IgG/IgG2 Hybrid and Point-Mutated Antibodies", Proc. Natl. Acad. Sci USA 88:9036-9040 (1991) (Exhibit 3). |
Davis et al., "Single Chain Antibody (SCA) Encoding Genes: One Step Construction and Expression in Eukaryotic Cells", Biotechnology 9:165-169 (Exhibit 4). |
Emmrich et al., "Selective Stimulation of Human T Lymphocyte Subsets by Heteroconjugates of Antibodies to the T-cell Receptor and to Subset-specific Differentiation Antigens", Eur. J. Immunol. 18:645-648 (1988) (Exhibit 5). |
Ford et al., "Fusion Tails for the Recovery and Purification of Recombinant Proteins", Protein Expression and Purification 2:95-107 (1991) (Exhibit 6). |
Fouser et al., "High Level Expression of a Chimeric Anti-Ganglioside GD2 Antibody: Genomic Kappa Sequences Improve Expression in COS and CHO Cells", Biotechnology 10:1121-1127 (1992) (Exhibit 7). |
Hieter et al., "Cloned Human and Mouse Kappa Immunoglobulin Constant and J Region Genes Conserve Homology in Functional Segments" Cell 22:197-207 (1980) (Exhibit 8). |
Jung et al., "Induction of Cytotoxicity in Resting Human T Lymphocytes Bound to Tumor Cells by Antibody Heteroconjugates", Proc. Natl. Acad. Sci. USA 84:4611-4615 (1987) (Exhibit 9). |
Ledbetter et al., "Signal Transduction Through CD4 Proximity to the CD3/T Cell Receptor", Eur. J. Immunol. 18:525-532 (1988) (Exhibit 10). |
Ledbetter et al., "Enhanced Transmembrane Signalling Activity of Monoclonal Antibody Heteroconjugates Suggest Molecular Interactions Between Receptors on the T Cell Surface", Mol. Immunol. 26:137-145 (1989) (Exhibit 11). |
Linsley et al., "Binding of the B Cell Activation Antigen B7 to CD28 Costimulates T Cell Proliferation and Interleukin 2 mRNA Accumulation", J. Exp. Med. 173:721-730 (1991) (Exhibit 12). |
Liu et al., "Heteroantibody Duplexes Target Cells for Lysis by Cytotoxic T Lymphocytes", Proc. Natl. Acad. Sci. USA 82:8648-8652 (1985) (Exhibit 13). |
Liu et al., "Chimeric Mouse-Human IgG1 Antibody that can Mediate Lysis of Cancer Cells", Proc. Natl. Acad. Sci. USA 84:3439-3443 (Exhibit 14). |
Lund et al., "Human Fc RI and Fc RII Interact with Distinct but Overlapping Sites on Human IgG", Journal of Immunology 147:2657-2662 (Exhibit 15). |
Mayforth et al., "Current Concepts: Designer and Catalytic Antibodies", New Eng. J. Med. 323:173-178 (1990) (Exhibit 16). |
Morrison, S. "In Vitro Antibodies: Strategies for Production and Application", Ann. Rev. Immunol. 10:239-266 (1992) (Exhibit 17). |
Neuberger et al., "Recombinant Antibodies Possessing Novel Effector Functions", Nature 312:604-608 (1984) (Exhibit 18). |
Orlandi et al., "Cloning Immunoglobulin Variable Domains for Expression by the Polymerase Chain Reaction", Proc. Nat. Acad. Sci. 86:3833-3837 (1989) (Exhibit 19). |
Perez et al., "Specific Targeting of Cytotoxic T Cells by Anti-T3 Linked to Anti-Target Cell Antibody" Nature 316:354-356 (1985) (Exhibit 20). |
Riechmann et al., "Expression of an Antibody Fv Fragment in Myeloma Cells" J. Mol. Biol. 203:825-828 (1988) (Exhibit 21). |
Shopes, B. "A Genetically Engineered Human IgG Mutant Cytolytic Activity", Journal of Immunology 9:2918-2922 (1992) (Exhibit 22). |
Staerz et al., "Hybrid Hybridoma Producing a Bispecific Monoclonal Antibody that can Focus Effector T-cell Activity", Proc. Natl. Acad. Sci. USA 83:1453-1457 (1986) (Exhibit 23). |
Traunecker et al., "Bispecific Single Chain Molecules (Janusins) Target Cytotoxic Lymphocytes on HIV Infected Cells", EMBO 10:3655-3659 (1991) (Exhibit 24). |
Emmrich et al., "Synergism in the Activation of Human CD8 T Cells by Cross-Linking the T-Cell Receptor Complex with the CD8 Differentiation Antigen", Proc. Natl. Acad. Sci. USA 83:8298-8302 (1986) (Exhibit 25). |
Wels et al., "Construction, Bacterial Expression and Characterization of a Bifunctional Single-Chain Antibody Phosphate Fusion Protein Targeted to the Human ERBB-2 Receptor", Biotechnology 10:1128-1132 (1992) (Exhibit 26). |
Winter et al., "Man Made Antibodies", Nature 349:293-299 (1991) (Exhibit 27). |
Pluckthun, A. "Mono-and Bivalent Antibody Fragments Produced in Escherichia coli: Engineering, Folding and Antigen Binding", Immunological Reviews 103:151-188 (1992) (Exhibit 28). |
Emmrich et al., "Synergism in the Activation of Human CD8 T Cells by Cross-linking the T-Cell Receptor Complex with the CD8 Differentiation Antigen", Proc. Natl. Acad. Sci. USA 83:8298-8302 (1986) (Exhibit 29). |
Bird et al., "Single-Chain Antigen-Binding Proteins", Science 24:423-426 (1988) (Exhibit 30). |
Hollinger et al., "Diabodies: Small Bivalent and Bispecific Antibody Fragments", Proc. Natl. Acad. Sci. USA 90:6444-6448 (1993) (Exhibit 31). |
Huston et al., Methods in Enzymology, vol. 203, 1991, pp. 47-89. |