Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor

Abstract

The present invention relates to nucleic acid molecules which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor.

Description

BACKGROUND OF THE INVENTION

The Sequence Listing file named “MBHB00,876-K SequenceListing.txt” (2,337,188 bytes in size) submitted on Compact Disc-Recordable (CD-R) medium (“010706 — 1627”) in compliance with 37 C.F.R. §1.52(e) is incorporated herein by reference.

This invention relates to methods and reagents for the treatment of diseases or conditions relating to the levels of expression of vascular endothelial growth factor (VEGF) receptor(s).

The following is a discussion of relevant art, none of which is admitted to be prior art to the present invention.

VEGF, also referred to as vascular permeability factor (VPF) and vasculotropin, is a potent and highly specific mitogen of vascular endothelial cells (for a review see Ferrara, 1993 Trends Cardiovas. Med. 3, 244; Neufeld et al., 1994 Prog. Growth Factor Res. 5, 89). VEGF induced neovascularization is implicated in various pathological conditions such as tumor angiogenesis, proliferative diabetic retinopathy, hypoxia-induced angiogenesis, rheumatoid arthritis, psoriasis, wound healing and others.

VEGF, an endothelial cell-specific mitogen, is a 34-45 kDa glycoprotein with a wide range of activities that include promotion of angiogenesis, enhancement of vascular-permeability and others. VEGF belongs to the platelet-derived growth factor (PDGF) family of growth factors with approximately 18% homology with the A and B chain of PDGF at the amino acid level. Additionally, VEGF contains the eight conserved cysteine residues common to all growth factors belonging to the PDGF family (Neufeld et al., supra). VEGF protein is believed to exist predominantly as disulfide-linked homodimers; monomers of VEGF have been shown to be inactive (Plouet et al., 1989 EMBO J. 8, 3801).

VEGF exerts its influence on vascular endothelial cells by binding to specific high-affinity cell surface receptors. Covalent cross-linking experiments with 125 I-labeled VEGF protein have led to the identification of three high molecular weight complexes of 225, 195 and 175 kDa presumed to be VEGF and VEGF receptor complexes (Vaisman et al., 1990 J. Biol. Chem. 265, 19461). Based on these studies VEGF-specific receptors of 180, 150 and 130 kDa molecular mass were predicted. In endothelial cells, receptors of 150 and the 130 kDa have been identified. The VEGF receptors belong to the superfamily of receptor tyrosine kinases (RTKs) characterized by a conserved cytoplasmic catalytic kinase domain and a hydrophylic kinase sequence. The extracellular domains of the VEGF receptors consist of seven immunoglobulin-like domains that are thought to be involved in VEGF binding functions.

The two most abundant and high-affinity receptors of VEGF are flt-1 (fms-like tyrosine kinase) cloned by Shibuya et al., 1990 Oncogene 5, 519 and KDR (kinase-insert-domain-containing receptor) cloned by Terman et al., 1991 Oncogene 6, 1677. The murine homolog of KDR, cloned by Mathews et al., 1991, Proc. Natl. Acad. Sci ., USA, 88, 9026, shares 85% amino acid homology with KDR and is termed as flk-1 (fet al liver kinase-1). Recently it has been shown that the high-affinity binding of VEGF to its receptors is modulated by cell surface-associated heparin and heparin-like molecules (Gitay-Goren et al., 1992 J. Biol. Chem. 267, 6093).

VEGF expression has been associated with several pathological states such as tumor angiogenesis, several forms of blindness, rheumatoid arthritis, psoriasis and others. Following is a brief summary of evidence supporting the involvement of VEGF in various diseases:

1) Tumor Angiogenesis

Increased levels of VEGF gene expression have been reported in vascularized and edema-associated brain tumors (Berkman et al., 1993 J. Clini. Invest. 91, 153). A more direct demostration of the role of VEGF in tumor angiogenesis was demonstrated by Jim Kim et al., 1993 Nature 362,841 wherein, monoclonal antibodies against VEGF were successfully used to inhibit the growth of rhabdomyosarcoma glioblastoma multiforme cells in nude mice. Similarly, expression of a dominant negative mutated form of the flt-1 VEGF receptor inhibits vascularization induced by human glioblastoma cells in nude mice (Millauer et al., 1994, Nature 367, 576).

2) Ocular Diseses

Aiello et al., 1994 New Engl. J. Med. 331, 1480, showed that the ocular fluid, of a majority of patients suffering from diabetic retinopathy and other retinal disorders, contains a high concentration of VEGF. Miller et al., 1994 Am. J. Pathol. 145, 574, reported elevated levels of VEGF mRNA in patients suffering from retinal ischemia. These observations support a direct role for VEGF in ocular diseases.

3) Psoriasis

Detmar et al., 1994 J. Exp. Med. 180, 1141 reported that VEGF and its receptors were over-expressed in psoriatic skin and psoriatic dermal microvessels, suggesting that VEGF plays a significant role in psoriasis.

4) Rheumatoid Arthritis

Immunohistochemistry and in situ hybridization studies on tissues from the joints of patients suffering from rheumatoid arthritis show an increased level of VEGF and its receptors (Fava et al., 1994 J. Exp. Med. 180, 341). Additionally, Koch et al., 1994 J. Immunol. 152, 4149, found that VEGF-specific antibodies were able to significantly reduce the mitogenic activity of synovial tissues from patients suffering from rheumatoid arthritis. These observations support a direct role for VEGF in rheumatoid arthritis.

In addition to the above data on pathological conditions involving excessive angiogenesis, a number of studies have demonstrated that VEGF is both necessary and sufficient for neovascularization. Takashita et al., 1995 J. Clin. Invest. 93, 662, demonstrated that a single injection of VEGF augmented collateral vessel development in a rabbit model of ischemia. VEGF also can induce neovascularization when injected into the cornea. Expression of the VEGF gene in CHO cells is sufficient to confer tumorigenic potential to the cells. Kim et al., supra and Millauer et al., supra used monoclonal antibodies against VEGF or a dominant negative form of flk-1 receptor to inhibit tumor-induced neovascularization.

During development, VEGF and its receptors are associated with regions of new vascular growth (Millauer et al. 1993 Cell 72, 835; Shalaby et al., 1993 J. Clin. Invest. 91, 2235). Furthermore. transgenic mice lacking either of the VEGF receptors are defective in blood vessel formation, infact these mouse do not survive; flk-1 appears to be required for differentiation of endothelial cells, while flt-1 appears to be required at later stages of vessel formation (Shalaby et al., 1995 Nature 376, 62; Fung et al., 1995 Nature 376, 66). Thus, these receptors must be present to properly signal endothelial cells or their precursors to respond to vascularization-promoting stimuli.

All of the conditions listed above, involve extensive vascularization. This hyper-stimulation of endothelial cells may be alleviated by VEGF antagonists. Thus most of the therapeutic efforts for the above conditions have concentrated on finding inhibitors of the VEGF protein.

Kim et al., 1993 Nature 362, 841 have been successful in inhibiting VEGF-induced tumor growth and angiogenesis in nude mice by treating the mice with VEGF-specific monoclonal antibody.

Koch et al., 1994 J. Immunol. 152, 4149 showed that the mitogenic activity of microvascular endothelial cells found in rheumatoid arthritis (RA) synovial tissue explants and the chemotactic property of endothelial cells from RA synovial fluid can be neutralized significantly by treatment with VEGF-specific antibodies.

Ullrich et al., International PCT Publication No. WO 94/11499 and Millauer et al., 1994 Nature 367, 576 used a soluble form of flk-1 receptor (dominant-negative mutant) to prevent VEGF-mediated tumor angiogenesis in immunodeficient mice.

Kendall and Thomas, International PCT Publication No. WO 94/21679 describe the use of naturally occuring or recombinantly-engineered soluble forms of VEGF receptors to inhibit VEGF activity.

Robinson, International PCT Publication No. WO 95/04142 describes the use of antisense oligonucleotides targeted against VEGF RNA to inhibit VEGF expression.

Jellinek et al., 1994 Biochemistry 33, 10450 describe the use of VEGF-specific high-affinity RNA aptamers to inhibit the binding of VEGF to its receptors.

Rockwell and Goldstein, International PCT Publication No. WO 95/21868, describe the use of anti-VEGF receptor monoclonal antibodies to neutralize the the effect of VEGF on endothelial cells.

SUMMARY OF THE INVENTION

The invention features novel nucleic acid-based techniques [e.g., enzymatic nucleic acid molecules (ribozymes), antisense nucleic acids, 2-5A antisense chimeras, triplex DNA, antisense nucleic acids containing RNA cleaving chemical groups (Cook et al., U.S. Pat. No. 5,359,051)] and methods for their use to down regulate or inhibit the expression of receptors of VEGF (VEGF−R).

In a preferred embodiment, the invention features use of one or more of the nucleic acid-based techniques to inhibit the expression of flt-1 and/or flk-1/KDR receptors.

By “inhibit” it is meant that the activity of VEGF−R or level of mRNAs or equivalent RNAs encoding VEGF−R is reduced below that observed in the absence of the nucleic acid. In one embodiment, inhibition with ribozymes preferably is below that level observed in the presence of an enzymatically inactive RNA molecule that is able to bind to the same site on the mRNA, but is unable to cleave that RNA. In another embodiment, inhibition with antisense oligonucleotides is preferably below that level observed in the presence of for example, an oligonucleotide with scrambled sequence or with mismatches.

By “enzymatic nucleic acid molecule” it is meant an RNA molecule which has complementarity in a substrate binding region to a specified gene target, and also has an enzymatic activity which is active to specifically cleave target RNA. That is, the enzymatic RNA molecule is able to intermolecularly cleave RNA and thereby inactivate a target RNA molecule. This complementary regions allow sufficient hybridization of the enzymatic RNA molecule to the target RNA and thus permit cleavage. One hundred percent complementarity is preferred, but complementarity as low as 50-75%. may also be useful in this invention. By “equivalent” RNA to VEGF−R is meant to include those naturally occurring RNA molecules in various animals, including human, mice, rats, rabbits, primates and pigs.

By “antisense nucleic acid” it is meant a non-enzymatic nucleic acid molecule that binds to target RNA by means of RNA-RNA or RNA-DNA or RNA-PNA (protein nucleic acid; Egholm et al., 1993 Nature 365, 566) interactions and alters the activity of the target RNA (for a review see Stein and Cheng, 1993 Science 261, 1004).

By “2-5A antisense chimera” it is meant, an antisense oligonucleotide containing a 5′ phosphorylated 2′-5′-linked adenylate residues. These chimeras bind to target RNA in a sequence-specific manner and activate a cellular 2-5A-dependent ribonuclease which, in turn, cleaves the target RNA (Torrence et al., 1993 Proc. Natl. Acad. Sci. USA 90, 1300).

By “triplex DNA” it is meant an oligonucleotide that can bind to a double-stranded DNA in a sequence-specific manner to form a triple-strand helix. Formation of such triple helix structure has been shown to inhibit transcription of the targeted gene (Duval-Valentin et al., 1992 Proc. Natl. Acad. Sci. USA 89, 504).

By “gene” it is meant a nucleic acid that encodes an RNA.

By “complementarity” it is meant a nucleic acid that can form hydrogen bond(s) with other RNA sequence by either traditional Watson-Crick or other non-traditional types (for example, Hoogsteen type) of base-paired interactions.

Six basic varieties of naturally-occurring enzymatic RNAs are known presently. Each can catalyze the hydrolysis of RNA phosphodiester bonds in trans (and thus can cleave other RNA molecules) under physiological conditions. Table I summarizes some of the characteristics of these ribozymes. In general. enzymatic nucleic acids act by first binding to a target RNA. Such binding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary base-pairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets. Thus, a single ribozyme molecule is able to cleave many molecules of target RNA. In addition, the ribozyme is a highly specific inhibitor of gene expression, with the specificity of inhibition depending not only on the base-pairing mechanism of binding to the target RNA, but also on the mechanism of target RNA cleavage. Single mismatches, or base-substitutions, near the site of cleavage can completely eliminate catalytic activity of a ribozyme.

Ribozymes that cleave the specified sites in VEGF−R mRNAs represent a novel therapeutic approach to treat tumor angiogenesis, ocular diseases, rhuematoid arthritis, psoriasis and others. Applicant indicates that ribozymes are able to inhibit the activity of VEGF−R (specifically flt-1 and flk-1/KDR) and that the catalytic activity of the ribozymes is required for their inhibitory effect. Those of ordinary skill in the art will find that it is clear from the examples described that other ribozymes that cleave VEGF−R mRNAs may be readily designed and are within the invention.

In preferred embodiments of this invention, the enzymatic nucleic acid molecule is formed in a hammerhead or hairpin motif, but may also be formed in the motif of a hepatitis delta virus, group I intron or RNaseP RNA (in association with an RNA guide sequence) or Neurospora VS RNA. Examples of such hammerhead motifs are described by Rossi et al., 1992, AIDS Research and Human Retroviruses 8, 183, of hairpin motifs by Hampel et al., EP0360257, Hampel and Tritz, 1989 Biochemistry 28, 4929, and Hampel et al., 1990 Nucleic Acids Res. 18, 299, and an example of the hepatitis delta virus motif is described by Perrotta and Been, 1992 Biochemistry 31, 16; of the RNaseP motif by Guerrier-Takada et al., 1983 Cell 35, 849, Neurospora VS RNA ribozyme motif is described by Collins (Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemisty 32, 2795-2799) and of the Group I intron by Cech et al., U.S. Pat. No. 4,987,071. These specific motifs are not limiting in the invention and those skilled in the art will recognize that all that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site which is complementary to one or more of the target gene RNA regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart an RNA cleaving activity to the molecule.

In a preferred embodiment the invention provides a method for producing a class of enzymatic cleaving agents which exhibit a high degree of specificity for the RNA of a desired target. The enzymatic nucleic acid molecule is preferably targeted to a highly conserved sequence region of target mRNAs encoding VEGF−R proteins (specifically flt-1 and flk-1/KDR) such that specific treatment of a disease or condition can be provided with either one or several enzymatic nucleic acids. Such enzymatic nucleic acid molecules can be delivered exogenously to specific tissue or cellular targets as required. Alternatively, the ribozymes can be expressed from DNA and/or RNA vectors that are delivered to specific cells.

Synthesis of nucleic acids greater than 100 nucleotides in length is difficult using automated methods, and the therapeutic cost of such molecules is prohibitive. In this invention, small nucleic acid motifs (e.g., antisense oligonucleotides, hammerhead or the hairpin ribozymes) are used for exogenous delivery. The simple structure of these molecules increases the ability of the nucleic acid to invade targeted regions of the mRNA structure. However, these nucleic acid molecules can also be expressed within cells from eukaryotic promoters (e.g., Izant and Weintraub, 1985 Science 229, 345; McGarry and Lindquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; SullengerScanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5; Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Dropulic et al., 1992 J. Virol, 66, 1432-41: Weerasinghe et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res. 23, 2259). Those skilled in the art realize that any nucleic acid can me expressed in eukaryotic cells from the appropriate DNA/RNA vector. The activity of such nucleic acids can be augmented by their release from the primary transcript by a ribozyme (Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595, both hereby incorporated in their totality by reference herein; Ohkawa et al., 1992 Nucleic Acids Symp. Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856).

Such nucleic acids are useful for the prevention of the diseases and conditions discussed above, and any other diseases or conditions that are related to the levels of VEGF−R(specifically flt-1 and flk-1/KDR) in a cell or tissue.

By “related” is meant that the reduction of VEGF−R (specifically flt-1 and flk-1/KDR) RNA levels and thus reduction in the level of the respective protein will relieve, to some extent, the symptoms of the disease or condition.

Ribozymes are added directly, or can be complexed with cationic lipids, packaged within liposomes, or otherwise delivered to target cells or tissues. The nucleic acid or nucleic acid complexes can be locally administered to relevant tissues ex vivo, or in vivo through injection, infusion pump or stent, with or without their incorporation in biopolymers. In preferred embodiments, the ribozymes have binding arms which are complementary to the sequences in Tables II to IX. Examples of such ribozymes also are shown in Tables II to IX. Examples of such ribozymes consist essentially of sequences defined in these Tables. By “consists essentially of” is meant that the active ribozyme contains an enzymatic center equivalent to those in the examples, and binding arms able to bind mRNA such that cleavage at the target site occurs. Other sequences may be present which do not interfere with such cleavage.

In another aspect of the invention, ribozymes that cleave target RNA molecules and inhibit VEGF−R (specifically flt-1 and flk-1/KDR) activity are expressed from transcription units inserted into DNA or RNA vectors. The recombinant vectors are preferably DNA plasmids or viral vectors. Ribozyme expressing viral vectors could be constructed based on, but not limited to, adeno-associated virus, retrovirus, adenovirus, or alphavirus. Preferably, the recombinant vectors capable of expressing the ribozymes are delivered as described above, and persist in target cells. Alternatively, viral vectors may be used that provide for transient expression of ribozymes. Such vectors might be repeatedly administered as necessary. Once expressed, the ribozymes cleave the target mRNA. Delivery of ribozyme expressing vectors could be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that would allow for introduction into the desired target cell.

By “vectors” is meant any nucleic acid- and/or viral-based techniqueused to deliver a desired nucleic acid.

Other features and advantages of the invention will be apparent from the following description of the preferred embodiments thereof, and from the claims.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

First the drawings will be described briefly.

Drawings

FIG. 1 is a diagrammatic representation of the hammerhead ribozyme domain known in the art. Stem II can be ≧2 base-pair long. (SEQ ID NO: 8215-8216)

FIG. 2 a is a diagrammatic representation of the hammerhead ribozyme domain known in the art;

FIG. 2 b is a diagrammatic representation of the hammerhead ribozyme as divided by Uhlenbeck (1987, Nature, 327, 596-600) into a substrate and enzyme portion;

FIG. 2 c is a similar diagram showing the hammerhead divided by Haseloff and Gerlach (1988, Nature , 334, 585-591) into two portion;

FIG. 2 d is a similar diagram showing the hammerhead divided by Jeffries and Symons (1989, Nucl. Acids. Res., 17, 1371-1371) into two portions.

FIG. 3 is a diagramatic representation of the general structure of a hairpin ribozyme. Helix 2 (H2) is provided with a least 4 base pairs (i.e., n is 1, 2, 3 or 4) and helix 5 can be optionally provided of length 2 or more bases (preferably 3-20 bases. i.e., m is from 1-20 or more). Helix 2 and helix 5 may be covalently linked by one or more bases (i.e., r is ≧1 base). Helix 1, 4 or 5 may also be extended by 2 or more base pairs (e.g., 4-20 base pairs) to stabilize the ribozyme structure, and preferably is a protein binding site. In each instance, each N and N′ independently is any normal or modified base, and each dash represents a potential base-pairing interaction. These nucleotides may be modified at the sugar, base or phosphate. Complete base-pairing is not required in the helices, but is preferred. Helix 1 and 4 can be of any size (i.e., o and p is each independently from 0 to any number, e.g., 20) as long as some base-pairing is maintained. Essential bases are shown as specific bases in the structure, but those in the art will recognize that one or more may be modified chemically (abasic, base, sugar and/or phosphate modifications) or replaced with another base without significant effect. Helix 4 can be formed from two separate molecules, i.e., without a connecting loop. The connecting loop when present may be a ribonucleotide with or without modifications to its base, sugar or phosphate. “q” is ≧2 bases. The connecting loop can also be replaced with a non-nucleotide linker molecule. H refers to bases A, U, or C. Y refers to pyrimidine bases. “_” refers to a covalent bond. (SEQ ID NO: 8217-8218)

FIG. 4 is a representation of the general structure of the hepatitis delta virus ribozyme domain known in the art. (SEQ ID NO: 8219)

FIG. 5 is a representation of the general structure of the VS RNA ribozyme domain. (SEQ ID NO: 8220)

FIG. 6 is a schematic representation of an RNAseH accessibility assay. Specifically, the left side of FIG. 6 is a diagram of complementary DNA oligonucleotides bound to accessible sites on the target RNA. Complementary DNA oligonucleotides are represented by broad lines labeled A, B, and C. Target RNA is represented by the thin, twisted line. The right side of FIG. 6 is a schematic of a gel separation of uncut target RNA from a cleaved target RNA. Detection of target RNA is by autoradiography of body-labeled, T7 transcript. The bands common to each lane represent uncleaved target RNA; the bands unique to each lane represent the cleaved products.

FIG. 7 shows the effect of hammerhead ribozymes targeted against flt-1 receptor on the binding of VEGF to the surface of human microvascular endothelial cells. Sequences of the ribozymes used are shown in Table II; the length of stem II region is 3 bp. The hammerhead ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions (see FIG. 11 ); U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ terminus contains phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose. The results of two separate experiments are shown as separate bars for each set. Each bar represents the average of triplicate samples. The standard deviation is shown with error bars. For the flt-1 data, 500 nM ribozyme (3:1 charge ratio with LipofectAMINE®) was used. Control 1-10 is the control for ribozymes 307-2797, control 11-20 is the control for ribozymes 3008-5585. The Control 1-10 and Control 11-20 represent the treatment of cells with LipofectAMINE® alone without any ribozymes.

FIG. 8 shows the effect of hammerhead ribozymes targeted against KDR receptor on the binding of VEGA to KDR on the surface of human microvascular endothelial cells. Sequences of the ribozymes used are shown in Table IV; the length of stem II region is 3 bp. The hammerhead ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions (see FIG. 11 ); U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ terminus contains phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose. The Control 1-10 and Control 11-20 represent the treatment of cells with LipofectAMINE®) alone without any ribozymes. Irrel. RZ, is a control experiment wherein the cells are treated with a non-KDR-targeted ribozyme complexed with Lipofectamine®. 200 nM ribozyme (3:1 charge ratio with LipofectAMINE(®) was used. In addition to the KDR-targeted ribozymes, the effect on VEGF binding of a ribozyme targeted to an irrelevant mRNA (irrel. RZ) is also shown. Because the affinity of KDR for VEGF is about 10-fold lower than the affinity of flt-1 for VEGF, a higher concentration of VEGF was used in the binding assay.

FIG. 9 shows the specificity of hammerhead ribozymes targeted against flt-1 receptor. Inhibition of the binding of VEGF, urokinase plasminogen activator (UPA) and fibroblast growth factor (FGF) to their corresponding receptors as a function of anti-FLT ribozymes is shown. The sequence and description of the ribozymes used are as described under FIG. 7 above. The average of triplicate samples is given; percent inhibition as calculated below.

FIG. 10 shows the inhibition of the proliferation of Human aortic endothelial cells (HAEC) mediated by phosphorothioate antisense oligodeoxynucleotides targeted against human KDR receptor RNA. Cell proliferation (O.D. 490) as a function of antisense oligodeoxynucleotide concentration is shown. KDR 21AS represents a 21 nt phosphorothioate antisense oligodeoxynucleotide targeted against KDR RNA. KDR 21 Scram represents a 21 nt phosphorothioate oligodeoxynucleotide having a scrambled sequence. LF represents the lipid carrier Lipofectin.

FIGS. 11 A 1 - 11 C shows in vitro cleavage of flt-1 RNA by hammerhead ribozymes. A 1 -A 2 ) diagrammatic representation of hammerhead ribozymes targeted against flt-1 RNA. The hammerhead (HH) ribozymes were chemicallymodified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ terminus contains phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (designated as 3′-iH). 1358 HH-A and 4229 HH-A contain 3 base-paired stem II region. 1358 HH-B and 4229 HH-B contain 4 base-paired stem II region. B (SEQ ID NO: 8221-8222, 8224-8226) and C) show in vitro cleavage kinetics of HH ribozymes targeted against sites 1358 and 4229 within the flt-1 RNA.

FIGS. 12 A 1 - 12 B shows inhibition of human microvascular endothelial cell proliferation mediated by anti-flt-1 hammerhead ribozymes. A) Diagrammatic representation of hammerhead (HH) ribozymes targeted against sites 1358 and 4229 within the the flt-1 RNA. B) Graphical representation of the inhibition of cell proliferation mediated by 1358HH and 4229HH ribozymes.(SEQ ID NO: 8221-8222, 8224-8225, 8228)

FIG. 13 shows inhibition of human microvascular endothelial cell proliferation mediated by anti-KDR hammerhead ribozymes. The figure is a graphical representation of the inhibition of cell proliferation mediated by hammerhead ribozymes targeted against sites 527, 730, 3702 and 3950 within the KDR RNA. Irrelevant HH RZ is a hammerhead ribozyme targeted to an irrelevant target. All of these ribozymes, including the Irrelevant HH RZ, were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ termini contain phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (3′-iH).

FIG. 14 shows in vitro cleavage of KDR RNA by hammerhead ribozymes. The hammerhead (HH) ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (designated as 3′-iH). 726 HH and 527 HH contain 4 base-paired stem II region. Percent in vitro cleavage kinetics as a function of time of HH ribozymes targeted against sites 527 and 726 within the KDR RNA is shown.

FIG. 15 shows in vitro cleavage of KDR RNA by hammerhead ribozymes. The hammerhead (HH) ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (designated as 3′-iH). 3702 HH and 3950 HH contain 4 base-paired stem II region. Percent in vitro cleavage kinetics as a function of time of HH ribozymes targeted against sites 3702 and 3950 within the KDR RNA is shown.

FIG. 16 shows in vitro cleavage of RNA by hammerhead ribozymes that are targeted to sites that are conserved between flt-1 and KDR RNA. The hammerhead (HH) ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (designated as 3′-iH). FLT/KDR-I HH ribozyme was synthesized with either a 4 base-paired or a 3 base-paired stem II region. FLT/KDR-I HH can cleave site 3388 within flt-1 RNA and site 3151 within KDR RNA. Percent in vitro cleavage kinetics as a function of time of HH ribozymes targeted against sites 3702 and 3950 within the KDR RNA is shown.

FIG. 17 shows inhibition of human microvascular endothelial cell proliferation mediated by anti-KDR and anti-flt-1 hammerhead ribozymes. The figure is a graphical representation of the inhibition of cell proliferation mediated by hammerhead ribozymes targeted against sites KDR sites −527, 726 or 3950 or flt-1 site 4229. The figure also shows enhanced inhibition of cell proliferation by a combination of flt-1 and KDR hammerhead ribozymes. 4229+527, indicates the treatment of cells with both the fit 4229 and the KDR 527 ribozymes. 4229+726, indicates the treatment of cells with both the fit 4229 and the KDR 726 ribozymes. 4229+3950, indicates the treatment of cells with both the fit 4229 and the KDR 3950 ribozymes. VEGF −, indicates the basal level of cell proliferation in the absence of VEGF. A, indicates catalytically active ribozyme; I, indicates catalytically inactive ribozyme. All of these ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ termini contain phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (3′-iH).

FIG. 18 shows the inhibition of VEGF-induced angiogenesis in rat cornea mediated by anti-flt-1 hammerhead ribozyme. All of these ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 position contains 2′-C-allyl modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ termini contain phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose (3′-iH). A decrease in the Surface Area corresponds to a reduction in angiogenesis. VEGF alone, corresponds to treatment of the cornea with VEGF and no ribozymes. Vehicle alone, corresponds to the treatment of the cornea with the carrier alone and no VEGF. This control gives a basal level of Surface Area. Active 4229 HH, corresponds to the treatment of cornea with the flt-1 4229 HH ribozyme in the absence of any VEGF. This control also gives a basal level of Surface Area. Active 4229 HH+VEGF, corresponds to the co-treatment of cornea with the flt-1 4229 HH ribozyme and VEGF. Inactive 4229 HH+VEGF, corresponds to the co-treatment of cornea with a catalytically inactive version of 4229 HH ribozyme and VEGF.

RIBOZYMES

Ribozymes of this invention block to some extent VEGF−R (specifically flt-1 and flk-1/KDR) production and can be used to treat disease or diagnose such disease. Ribozymes will be delivered to cells in culture, to cells or tissues in animal models of angiogenesis and/or RA and to human cells or tissues ex vivo or in vivo. Ribozyme cleavage of VEGF−R RNAs (specifically RNAs that encode flt-1 and flk-1/KDR) in these systems may alleviate disease symptoms.

Target Sites

Targets for useful ribozymes can be determined as disclosed in Draper et al., International PCT Publication No. WO 95/13380, and hereby incorporated by reference herein in totality. Other examples include the following PCT applications which concern inactivation of expression of disease-related genes: WO 95/23225, WO 95/13380, WO 94/02595, incorporated by reference herein. Rather than repeat the guidance provided in those documents here, below are provided specific examples of such methods, not limiting to those in the art. Ribozymes to such targets are designed as described in those applications and synthesized to be tested in vitro and in vivo, as also described.

The sequence of human and mouse flt-1, KDR and/or flk-1 mRNAs were screened for optimal ribozyme target sites using a computer folding algorithm. Hammerhead or hairpin ribozyme cleavage sites were identified. These sites are shown in Tables II to IX (all sequences are 5′ to 3′ in the tables; X can be any base-paired sequence, the actual sequence is not relevant here). The nucleotide base position is noted in the Tables as that site to be cleaved by the designated type of ribozyme. While mouse and human sequences can be screened and ribozymes thereafter designed, the human targeted sequences are of most utility. However, as discussed in Stinchcomb et al., “Method and Composition for Treatment of Restenosis and Cancer Using Ribozymes,” filed May 18, 1994, U.S. Ser. No. 08/245,466, mouse targeted ribozymes may be useful to test efficacy of action of the ribozyme prior to testing in humans. The nucleotide base position is noted in the Tables as that site to be cleaved by the designated type of ribozyme.

Hammerhead or hairpin ribozymes were designed that could bind and cleave target RNA in a sequence-specific manner. The ribozymes were individually analyzed by computer folding (Jaeger et al., 1989 Proc. Natl. Acad. Sci. USA, 86, 7706) to assess whether the ribozyme sequences fold into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core were eliminated from consideration. Varying binding arm lengths can be chosen to optimize activity.

Referring to FIG. 6 , mRNA is screened for accessible cleavage sites by the method described generally in Draper et al., PCT WO93/23569, hereby incorporated by reference herein. Briefly, DNA oligonucleotides complementary to potential hammerhead or hairpin ribozyme cleavage sites were synthesized. A polymerase chain reaction is used to generate substrates for T7 RNA polymerase transcription from human and mouse flt-1, KDR and/or flk-1 cDNA clones. Labeled RNA transcripts are synthesized in vitro from the templates. The oligonucleotides and the labeled transcripts were annealed, RNAseH was added and the mixtures were incubated for the designated times at 37° C. Reactions are stopped and RNA separated on sequencing polyacrylamide gels. The percentage of the substrate cleaved is determined by autoradiographic quantitation using a PhosphorImaging system. From these data, hammerhead or hairpin ribozyme sites are chosen as the most accessible.

Ribozymes of the hammerhead or hairpin motif were designed to anneal to various sites in the mRNA message. The binding arms are complementary to the target site sequences described above. The ribozymes were chemically synthesized. The method of synthesis used follows the procedure for normal RNA synthesis as described in Usman et al., 1987 J. Am. Chem. Soc., 109, 7845; Scaringe et al., 1990 Nucleic Acids Res., 18, 5433; and Wincott et al., 1995 Nucleic Acids Res. 23, 2677-2684 and makes use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5′-end, and phosphoramidites at the 3′-end. Small scale synthesis were conducted on a 394 Applied Biosystems, Inc. synthesizer using a modified 2.5 μmol scale protocol with a 5 min coupling step for alkylsilyl protected nucleotides and 2.5 min coupling step for 2′-O-methylated nucleotides. Table XI outlines the amounts, and the contact times, of the reagents used in the synthesis cycle. A 6.5-fold excess (163 μL of 0.1 M=16.3 μmol) of phosphoramidite and a 24-fold excess of S-ethyl tetrazole (238 μL of 0.25 M=59.5 μmol) relative to polymer-bound 5′-hydroxyl was used in each coupling cycle. Average coupling yields on the 394 Applied Biosystems, Inc. synthesizer, determined by colorimetric quantitation of the trityl fractions, were 97.5-99%. Other oligonucleotide synthesis reagents for the 394 Applied Biosystems, Inc. synthesizer : detritylation solution was 2% TCA in methylene chloride (ABI); capping was performed with 16% N-methyl imidazole in THF (ABI) and 10% acetic anhydride/10% 2,6-lutidine in THF (ABI); oxidation solution was 16.9 mM I 2 , 49 mM pyridine, 9% water in THF (Millipore). B & J Synthesis Grade acetonitrile was used directly from the reagent bottle. S-Ethyl tetrazole solution (0.25 M in acetonitrile) was made up from the solid obtained from American International Chemical, Inc.

Deprotection of the RNA was performed as follows. The polymer-bound oligoribonucleotide, trityl-off, was transferred from the synthesis column to a 4 mL glass screw top vial and suspended in a solution of methylamine (MA) at 65° C. for 10 min. After cooling to −20° C., the supernatant was removed from the polymer support. The support was washed three times with 1.0 mL of EtOH:MeCN:H 2 O/3:1:1, vortexed and the supernatant was then added to the first supernatant. The combined supernatants, containing the oligoribonucleotide, were dried to a white powder.

The base-deprotected oligoribonucleotide was resuspended in anhydrous TEA.HF/NMP solution (250 μL of a solution of 1.5 mL N-methyl-pyrrolidinone, 750 μL TEA and 1.0 mL TEA3.HF to provide a 1.4M HF concentration) and heated to 65° C. for 1.5 h. The resulting, fully deprotected, oligomer was quenched with 50 mM TEAB (9 mL) prior to anion exchange desalting.

For anion exchange desalting of the deprotected oligomer, the TEAB solution was loaded onto a Qiagen 500® anion exchange cartridge (Qiagen Inc.) that was prewashed with 50 mM TEAB (10 mL). After washing the loaded cartridge with 50 mM TEAB (10 mL), the RNA was eluted with 2 M TEAB (10 mL) and dried down to a white powder.

Inactive hammerhead ribozymes were synthesized by substituting a U for G5 and a U for A14 (numbering from Hertel, K. J., et al., 1992, Nucleic Acids Res., 20, 3252). The average stepwise coupling yields were >98% (Wincott et al., 1995 Nucleic Acids Res. 23, 2677-2684).

Hairpin ribozymes are synthesized in two parts and annealed to reconstruct the active ribozyme (Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840). Ribozymes are also synthesized from DNA templates using bacteriophage T7 RNA polymerase (Milligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51).

All ribozymes are modified extensively to enhance stability by modification with nuclease resistant groups, for example, 2′-amino, 2′-C-allyl, 2′-flouro, 2′-O-methyl, 2′-H (for a review see Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163). Ribozymes are purified by gel electrophoresis using general methods or are purified by high pressure liquid chromatography (HPLC; See Usman et al., Synthesis, deprotection, analysis and purification of RNA and ribozymes, filed May, 18, 1994, U.S. Ser. No. 08/245,736 Wincott et al., Supra, the totality of which is hereby incorporated herein by reference) and are resuspended in water.

The sequences of the ribozymes that are chemically synthesized, useful in this study, are shown in Tables II to IX. Those in the art will recognize that these sequences are representative only of many more such sequences where the enzymatic portion of the ribozyme (all but the binding arms) is altered to affect activity. Stem-loop IV sequence of hairpin ribozymes listed in for example Table III (5′-CACGUUGUG-3′) can be altered (substitution, deletion, and/or insertion) to contain any sequence, provided a minimum of two base-paired stem structure can form. The sequences listed in Tables II to IX may be formed of ribonucleotides or other nucleotides or non-nucleotides. Such ribozymes are equivalent to the ribozymes described specifically in the Tables.

Optimizing Ribozyme Activity

Ribozyme activity can be optimized as described by Stinchcomb et al., supra. The details will not be repeated here, but include altering the length of the ribozyme binding arms (stems I and III, see FIG. 2 c ), or chemically synthesizing ribozymes with modifications that prevent their degradation by serum ribonucleases (see e.g., Eckstein et al., International Publication No.

WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Biochem. Sci. 17, 334; Usman et al., International Publication No. WO 93/15187; Rossi et al., International Publication No. WO 91/03162; Beigelman et al., 1995 J. Biol Chem . in press; as well as Sproat, U.S. Pat. No. 5,334,711 which describe various chemical modifications that can be made to the sugar moieties of enzymatic RNA molecules). Modifications which enhance their efficacy in cells, and removal of stem II bases to shorten RNA synthesis times and reduce chemical requirements are desired. (All these publications are hereby incorporated by reference herein).

Sullivan, et al., supra, describes the general methods for delivery of enzymatic RNA molecules. Ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but not restricted to, encapsulation in liposomes. by iontophoresis, or by incorporation into other vehicles. such as hydrogels, cyclodextrins, biodegradable nanocapsules, and bioadhesive microspheres. For some indications, ribozymes may be directly delivered ex vivo to cells or tissues with or without the aforementioned vehicles. Alternatively, the RNA/vehicle combination is locally delivered by direct injection or by use of a catheter, infusion pump or stent. Other routes of delivery include, but are not limited to, intravascular, intramuscular, subcutaneous or joint injection, aerosol inhalation, oral (tablet or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan et aL, supra and Draper et al., supra which have been incorporated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s) within cells is to incorporate the ribozyme-encoding sequences into a DNA or RNA expression vector. Transcription of the ribozyme sequences are driven from a promoter for eukaryotic RNA polymerase I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcripts from pol II or pol III promoters will be expressed at high levels in all cells; the levels of a given pol II promoter in a given cell type will depend on the nature of the gene regulatory sequences (enhancers, silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters are also used, providing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990 Proc. Natl. Acad. Sci. U S A, 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res., 21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37; Thompson et al., 1995 supra). Several investigators have demonstrated that ribozymes expressed from such promoters can function in mammalian cells (e.g. Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. U S A, 89,10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci. U S A, 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. U. S. A., 90, 8000-4; Thompson et al., 1995 Nucleic Acids Res. 23, 2259). The above ribozyme transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vectors (such as adenovirus or adeno-associated virus vectors), or viral RNA vectors (such as retroviral or alphavirus vectors).

In a preferred embodiment of the invention, a transcription unit expressing a ribozyme that cleaves RNAs that encode flt-1, KDR and/or flk-1 are inserted into a plasmid DNA vector or an adenovirus or adeno-associated virus DNA viral vector or a retroviral RNA vector. Viral vectors have been used to transfer genes and lead to either transient or long term gene expression (Zabner et aL, 1993 Cell 75, 207; Carter, 1992 Curr. Opi. Biotech. 3, 533). The adenovirus, AAV or retroviral vector is delivered as recombinant viral particles. The DNA may be delivered alone or complexed with vehicles (as described for RNA above). The recombinant adenovirus or AAV or retroviral particles are locally administered to.,the site of, treatment, e.g., through incubation or inhalation in vivo or by direct application to cells or tissues ex vivo. Retroviral vectors have also been used to express ribozymes in mammalian cells (Ojwang et al., 1992 supra; Thompson et al., 1995 supra).

fit-1, KDR and/or flk-1 are attractive nucleic acid-based therapeutic targets by several criteria. The interaction between VEGF and VEGF−R is well-established. Efficacy can be tested in well-defined and predictive animal models. Finally, the disease conditions are serious and current therapies are inadequate. Whereas protein-based therapies would inhibit VEGF activity nucleic acid-based therapy provides a direct and elegant approach to directly modulate flt-1, KDR and/or flk-1 expression.

Because flt-1 and KDR mRNAs are highly homologous in certain regions, some ribozyme target sites are also homologous (see Table X). In this case, a single ribozyme will target both flt-1 and KDR mRNAs. At partially homologous sites, a single ribozyme can sometimes be designed to accomodate a site on both mRNAs by including G/U basepairing. For example, if there is a G present in a ribozyme target site in KDR mRNA at the same position there is an A in the flt-1 ribozyme target site, the ribozyme can be synthesized with a U at the complementary position and it will bind both to sites. The advantage of one ribozyme that targets both VEGF−R mRNAs is clear, especially in cases where both VEGF receptors may contribute to the progression of angiogenesis in the disease state.

“Angiogenesis” refers to formation of new blood vessels which is an essential process in reproduction, development and wound repair. “Tumor angiogenesis” refers to the induction of the growth of blood vessels from surrounding tissue into a solid tumor. Tumor growth and tumor metastasis are dependent on angiogenesis (for a review see Folkman, 1985 supra; Folkman 1990 J. Natl. Cancer Inst., 82, 4; Folkman and Shing, 1992 J. Biol. Chem. 267, 10931).

Angiogenesis plays an important role in other diseases such as arthritis wherein new blood vessels have been shown to invade the joints and degrade cartilage (Folkman and Shing, supra).

“Retinopathy” refers,to inflammation of the retina and/or degenerative condition of the retina which may lead to occlusion of the retina and eventual blindness. In “diabetic retinopathy” angiogenesis causes the capillaries in the retina to invade the vitreous resulting in bleeding and blindness which is also seen in neonatal retinopathy (for a review see Folkman, 1985 supra; Folkman 1990 supra; Folkman and Shing, 1992 supra).

EXAMPLE 1

flt-1, KDR and/or flk-1 Ribozymes

By engineering ribozyme motifs applicant has designed several ribozymes directed against flt-1, KDR and/or flk-1 encoded mRNA sequences. These ribozymes were synthesized with modifications that improve their nuclease resistance (Beigelman et al., 1995 J Biol. Chem. 270, 25702) and enhance their activity in cells. The ability of ribozymes to cleave target sequences in vitro was evaluated essentially as described in Thompson et al., PCT Publication No. WO 93/23057; Draper et al., PCT Publication No. WO 95/04818.

EXAMPLE 2

Effect of Ribozymes on the Binding of VEGF to flt-1, KDR and/or flk-1 Receptors

Several common human cell lines are available that express endogenous flt-1, KDR and/or flk-1, flt-1, KDR and/or flk-1 can be detected easily with monoclonal antibodies. Use of appropriate fluorescent reagents and fluorescence-activated cell-sorting (FACS) will permit direct quantitation of surface flt-1, KDR and/or flk-1 on a cell-by-cell basis. Active ribozymes are expected to directly educe flt-1, KDR and/or flk-1 expression and thereby reduce VEGF binding to the cells. In this example, human umbelical cord microvascular endothelial cells were used.

Cell Preparation

Plates are coated with 1.5% gelatin and allowed to stand for one hour. Cells (e.g., microvascular endothelial cells derived from human umbilical cord vein) are plated at 20,000 cells/well (24 well plate) in 200 μl growth media and incubated overnight (˜1 doubling) to yield ˜40,000 cells (75-80% confluent).

Ribozyme Treatment

Media is removed from cells and the cells are washed two times with 300 μl 1×PBS: Ca 2+ : Mg 2+ mixture. A complex of 200-500 nM ribozyme and LipofectAMINE® (3:1 lipid:phosphate ratio) in 200 μl OptiMEM® (5% FBS) was added to the cells. The cells are incubated for 6 hr (equivalent to 2-3 VEGF−R turnovers).

125 I VEGF Binding Assay

The assay is carried out on ice to inhibit internalization of VEGF during the experiment. The media containing the ribozyme is removed from the cells and the cells are washed twice with with 300 μl 1×PBS: Ca 2+ : Mg 2+ mixture containing 1% BSA. Appropriate 125 I VEGF solution (100,000 cpm/well, +/−10 × cold 1×PBS, 1% BSA) was applied to the cells. The cells are incubated on ice for 1 h. 125 I VEGF-containing solution is removed and the cells are washed three times with with 300 μl 1×PBS: Ca 2+ : Mg 2+ mixture containing 1% BSA. To each well 300 μl of 100 mM Tris-HCl, pH 8.0, 0.5% Triton X-100 was added and the the mixture was incubated for 2 min. The 125 I VEGF-binding was quantitated using standard scintillation counting techniques. Percent inhibition was calculated as follows: $$ Percent ⁢   ⁢ Inhibition = cpm 125 &RightBracketingBar; ⁢ VEGF ⁢   ⁢ bound ⁢   ⁢ by ⁢   ⁢ the ⁢   ⁢ ribozyme ⁢ - ⁢ treated ⁢   ⁢ samples cpm 125 &RightBracketingBar; ⁢ VEGF ⁢   ⁢ bound ⁢   ⁢ by ⁢   ⁢ the ⁢   ⁢ Control ⁢   ⁢ sample × 100

EXAMPLE 3

Effect of Hammerhead Ribozymes Targeted Against flt-1 Receptor on the Binding of VEGF

Hammerhead ribozymes targeted to twenty sites within flt-1 RNA were synthesized as described above. Sequence of the ribozymes used are shown in Table II; the length of stem II region is 3 bp. The hammerhead ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ terminus contains phosphorothioate substitutions. Additionally, 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic ribose.

Referring to FIG. 7 , the effect of hammerhead ribozymes targeted against flt-1 receptor on the binding of VEGF to flt-1 on the surface of human microvascular endothelial cells is shown. The majority of the ribozymes tested were able to inhibit the expression of flt-1 and thereby were able to inhibit the binding of VEGF.

In order to determine the specificity of ribozymes targeted against flt-1 RNA, the effect of five anti-flt-1 ribozymes on the binding of VEGF, UPA (urokinase plasminogen activator) and FGF (fibroblast growth factor) to their corresponding receptors were assayed. As shown in FIG. 9 , there was significant inhibition of VEGF binding to its receptors on cells treated with anti-flt-1 ribozymes. There was no specific inhibition of the binding of UPA and FGF to their corresponding receptors. These data strongly suggest that anti-flt-1 ribozymes specifically cleave flt-1 RNA and not RNAs encoding the receptors for UPA and FGF, resulting in the inhibition of flt-1 receptor expression on the surface of the cells. Thus the ribozymes are responsible for the inhibition of VEGF binding but not the binding of UPA and FGF.

EXAMPLE 4

Effect of Hammerhead Ribozymes Targeted Against KDR Receptor on the Binding of VEGF

Hammerhead ribozymes targeted to twenty one sites within KDR RNA were synthesized as described above. Sequence of the ribozymes used are shown in Table IV; the length of stem II region is 3 bp. The hammerhead ribozymes were chemically modified such that the ribozyme consists of ribose residues at five positions; U4 and U7 positions contain 2′-NH 2 modifications, the remaining nucleotide positions contain 2′-O-methyl substitutions; four nucleotides at the 5′ terminus contains phosphorothioate substitutions. Additionally, the 3′ end of the ribozyme contains a 3′-3′ linked inverted abasic deoxyribose.

Referring to FIG. 8 , the effect of hammerhead ribozymes targeted against KDR receptor on the binding of VEGF to KDR on the surface of human microvascular endothelial cells is shown. A majority of the ribozymes tested were able to inhibit the expression of KDR and thereby were able to inhibit the binding of VEGF. As a control, the cells were treated with a ribozyme that is not targeted towards KDR RNA (irrel. RZ); there was no specific inhibition of VEGF binding. The results from this control experiment strongly suggest that the inhibition of VEGF binding observed with anti-KDR ribozymes is a ribozyme-mediated inhibition.

EXAMPLE 5

Effect of Ribozymes Targeted Against VEGF Receptors on Cell Proliferation

Cell Preparation

24-well plates are coated with 1.5% gelatin (porcine skin 300 bloom). After 1 hr, excess gelatin is washed off of the plate. Microvascular endothelial cells are plated at 5,000 cells/well (24 well plate) in 200 μl growth media. The cells are allowed to grow for ˜18 hr (˜1 doubling) to yield ˜10,000 cells (25-30% confluent).

Ribozyme Treatment

Media is removed from the cells, and the cells are washed two times with 300 μl 1×PBS: Ca 2+ : Mg 2+ mixture.

For anti-flt-1 HH ribozyme experiment ( FIG. 12 ) a complex of 500 nM ribozyme; 15 μM LFA (3:1 lipid:phosphate ratio) in 200 μl OptiMEM (5% FCS) media was added to the cells. Incubation of cells is carried out for 6 hr (equivalent to 2-3 VEGF receptor turnovers).

For anti-KDR HH ribozyme experiment ( FIG. 13 ) a complex of 200 nM ribozyme; 5.25 μM LFA (3:1 lipid:phosphate ratio) in 200 μl OptiMEM (5% FCS) media was added to the cells. Incubation of cells is carried out for 3 hr.

Proliferation

After three or six hours, the media is removed from the cells and the cells are washed with 300 μl 1×PBS: Ca 2+ : Mg 2+ mixture. Maintenance media (contains dialyzed 10% FBS) +/−VEGF or basic FGF at 10 ng/ml is added to the cells. The cells, are incubated for 48 or 72 h. The cells are trypsinized and counted (Coulter counter). Trypan blue is added on one well of each treatment as control.

As shown in FIG. 12B , VEGF and basic FGF can stimulate human microvascular endothelial cell proliferation. However, treatment of cells with 1358 HH or 4229 HH ribozymes, targeted against flt-1 mRNA, results in a significant decrease in the ability of VEGF to stimulate endothelial cell proliferation. These ribozymes do not inhibit the FGF-mediated stimulation of endothelial cell proliferation.

Human microvascular endothalial cells were also treated with hammerhead ribozymes targeted against sites 527, 730, 3702 or 3950 within the KDR mRNA. As shown in FIG. 13 , all four ribozymes caused significant inhibition of VEGF-mediated induction of cell proliferation. No significant inhibition of cell proliferation was observed when the cells were treated with a hammerhead ribozyme targeted to an irrelevant RNA. Additionally, none of the ribozymes inhibited FGF-mediated stimulation of cell proliferation.

These results strongly suggest that hammerhead ribozymes targeted against either flt-1 or KDR mRNA can specifically inhibit VEGF-mediated induction of endothelial cell proliferation.

EXAMPLE 6

Effect of Antisense Oligonucleotides Targeted Against VEGF Receptors on Cell Proliferation (Calorimetric Assay)

Following are some of the reagents used in the proliferation assay:

Cells

Human aortic endothelial cells (HAEC) from Clonetics®. Cells at early passage are preferably used.

Uptake Medium

EBM (from Clonetics®);1% L-Glutamine;20 mM Hepes;No serum;No antibiotics.

Growth Medium

EGM (from Clonetics®);FBS to 20%;1% L-Glutamine; 20 mM Hepes.

Cell Plating

96-well tissue culture plates are coated with 0.2% gelatin (50 μl/well). The gelatin is incubated in the wells at room temperature for 15-30 minutes. The gelatin is removed by aspiration and the wells are washed with PBS:Ca 2+ : Mg 2+ mixture. PBS mixture is left in the wells until cells are ready to be added. HAEC cells were detached by trypsin treatment and resuspended at 1.25×10 4 /ml in growth medium. PBS is removed from plates and 200 μl of cells (i.e. 2.5×10 3 cells/well) are added to each well. The cells are allowed to grow for 48 hours before the proliferation assay.

Assay

Growth medium is removed from the wells. The cells are washed twice with PBS:Ca 2+ : Mg 2+ mixture without antibiotics. A formulation of lipid/antisense oligonucleotide (antisense oligonucleotide is used here as a non-limiting example) complex is added to each well (100 μl/well) in uptake medium. The cells are incubated for 2-3 hours at 37° C. in CO 2 incubator. After uptake, 100 μl/well of growth medium is added (gives final FBS concentration of 10%). After approximately 72 hours, 40 μl MTS® stock solution (made as described by manufacturer) was added to each well and incubated at 37° C. for 1-3 hours, depending on the color development. (For this assay, 2 hours was sufficient). The intensity of color formation was determined on a plate reader at 490 nM.

Phosphorothioate-substituted antisense oligodeoxynucleotides were custom synthesized by The Midland Certified Reagent Company®, Midland, Tex. Following non-limiting antisense oligodeoxynucleotides targeted against KDR RNA were used in the proliferation assay:

KDR 21 AS: 5′-GCA GCA CCT TGC TCT CCA TCC-3′  (SEQ ID NO. 8230)

SCRAMBLED CONTROL: 5′-CTG CCA ACT TCC CAT GCC TGC-3′  (SEQ ID NO. 8231)

As shown in FIG. 10 , proliferation of HAEC cells are specifically inhibited by increasing concentrations of the phosphorothioate anti-KDR-antisense oligodeoxynucleotide. The scrambled antisense oligonucleotide is not expected to bind the KDR RNA and therefore is not expected to inhibit KDR expression. As expected, there is no detectable inhibition of proliferation of HAEC cells treated with a phosphorothioate antisense oligonucleotide with scrambled sequence.

EXAMPLE 7

In vitro Cleavage of flt-1 RNA by Hammerhead Ribozymes

Referring to FIG. 11A , hammerhead ribozymes (HH) targeted against sites 1358 and 4229 within the flt-1 RNA were synthesized as described above.

RNA Cleavage Assay In vitro

Substrate RNA was 5′ end-labeled using [γ- 32 P] ATP and T4 polynucleotide kinase (US Biochemicals). Cleavage reactions were carried out under ribozyme “excess” conditions. Trace amount (≦1 nM) of 5′ end-labled substrate and 40 nM unlabeled ribozyme were denatured and renatured separately by heating to 90° C. for 2 min and snap-cooling on ice for 10-15 min. The ribozyme and substrate were incubated, separately, at 37° C. for 10 min in a buffer containing 50 mM Tris-HCl and 10 mM MgCl 2 . The reaction was initiated by mixing the ribozyme and substrate solutions and incubating at 37° C. Aliquots of 5 μl are taken at regular intervals of time and the reaction is quenched by mixing with equal volume of 2×formamide stop mix. The samples are resolved on 20% denaturing polyacrylamide gels. The results were quantified and percentage of target RNA, cleaved is plotted as a function of time.

Referring to FIGS. 11B and 11C , hammerhead ribozymes targeted against sites 1358 and 4229 within the flt-1 RNA are capable of cleaving target RNA efficiently in vitro.

EXAMPLE 8

In vitro Cleavage of KDR RNA by Hammerhead Ribozymes

In this non-limiting example, hammerhead ribozymes targeted against sites 726, 527, 3702 and 3950 within KDR RNA were synthesized as described above. RNA cleavage reactions were carried out in vitro essentially as described under Example 7.

Referring to FIGS. 14 and 15 , all four ribozymes were able to cleave their cognate target RNA efficiently in a sequence-specific manner.

EXAMPLE 9

In vitro Cleavage of RNA by Hammerhead Ribozymes Targeted Against Cleavage Sites that Are Homologous Between KDR and flt-1 mRNA

Because flt-1 and KDR mRNAs are highly homologous in certain regions, some ribozyme target sites are also homologous (see Table X). In this case, a single ribozyme will target both flt-1 and KDR mRNAs. Hammerhead ribozyme (FLT/KDR-1) targeted against one of the homologous sites between fit-1 and KDR (fit-1 site 3388 and KDR site 3151) was synthesized as described above. Ribozymes with either a 3 bp stem II or a 4 bp stem II were synthesized. RNA cleavage reactions were carried out in vitro essentially as described under Example 7.

Referring to FIG. 16 , FLT/KDR-I ribozyme with either a 3 or a 4 bp stem II was able to cleave its target RNA efficiently in vitro.

EXAMPLE 10

Effect of Multiple Ribozymes Targeted Against Both flt-1 and KDR RNA on Cell Proliferation

Since both flt-1 and KDR receptors of VEGF are involved in angiogenesis, the inhibition of the expression of both of these genes may be an effective approach to inhibit angiogenesis.

Human microvascular endothalial cells were treated with hammerhead ribozymes targeted against sites flt-1 4229 alone, KDR 527 alone, KDR 726 alone, KDR 3950 alone. flt-1 4229+KDR 527, flt-1 4229+KDR 726 or flt-1 4229+KDR 3950. As shown in FIG. 17 , all the combinations of active ribozymes (A) caused significant inhibition of VEGF-mediated induction of cell proliferation. No significant inhibition of cell proliferation was observed when the cells were treated with a catalytically inactive (I) hammerhead ribozymes. Additionally, cells treated with ribozymes targeted against both flt-1 and KDR RNAs—flt-1 4229+KDR 527; flt-1 4229+KDR 726; flt-1 4229+KDR 3950, were able to cause a greater inhibition of VEGF-mediated induction of cell proliferation when compared with individual ribozymes targeted against either fit-1 or KDR RNA (see flt-1 4229 alone; KDR 527 alone; KDR 726 alone; KDR 3950 alone). This strongly suggests that treatment of cells with multiple ribozymes may be a more effective means of inhibition of gene expression.

Animal Models

There are several animal models in which the anti-angiogenesis effect of nucleic acids of the present invention, such as ribozymes, directed against VEGF−R mRNAs can be tested. Typically a corneal model has been used to study angiogenesis in rat and rabbit since recruitment of vessels can easily be followed in this normally avascular tissue (Pandey et al., 1995 Science 268: 567-569). In these models, a small Teflon or Hydron disk pretreated with an angiogenesis factor (e.g. bFGF or VEGF) is inserted into a pocket surgically created in the cornea. Angiogenesis is monitored 3 to 5 days later. Ribozymes directed against VEGF−R mRNAs would be delivered in the disk as well, or dropwise to the eye over the time course of the experiment. In another eye model, hypoxia has been shown to cause both increased expression of VEGF and neovascularization in the retina (Pierce et al., 1995 Proc. Natl. Acad. Sci . USA. 92: 905-909; Shweiki et aL, 1992 J. Clin. Invest. 91: 2235-2243).

In human glioblastomas, it has been shown that VEGF is at least partially responsible for tumor angiogenesis (Plate et al., 1992 Nature 359, 845). Animal models have been developed in which glioblastoma cells are implanted subcutaneously into nude mice and the progress of tumor growth and angiogenesism is studied (Kim et al., 1993 supra; Millauer et al., 1994 supra).

Another animal model that addresses neovascularization involves Matrigel, an extract of basement membrane that becomes a solid gel when injected subcutaneously (Passaniti et al., 1992 Lab. Invest. 67: 519-528). When the Matrigel is supplemented with angiogenesis factors such as VEGF, vessels grow into the Matrigel over a period of 3 to 5 days and angiogenesis can be assessed. Again, ribozymes directed against VEGF−R mRNAs would be delivered in the Matrigel.

Several animal models exist for screening of anti-angiogenic agents. These include corneal vessel formation following corneal injury (Burger et al., 1985 Cornea 4: 35-41; Lepri, et al., 1994 J. Ocular Pharmacol. 10: 273-280; Ormerod et al., 1990 Am. J. Pathol. 137: 1243-1252) or intracorneal growth factor implant (Grant et al., 1993 Diabetologia 36: 282-291; Pandey et al. 1995 supra; Zieche et al., 1992 Lab. Invest. 67: 711-715), vessel growth into Matrigel matrix containing growth factors (Passaniti et al., 1992 supra), female reproductive organ neovascularization following hormonal manipulation (Shweiki et al., 1993 Clin. Invest. 91: 2235-2243), several models involving inhibition of tumor growth in highly vascularized solid tumors (O'Reilly et aL, 1994 Cell 79: 315-328; Senger et al., 1993 Cancer and Metas. Rev. 12: 303-324; Takahasi et al., 1994 Cancer Res. 54: 4233-4237; Kim et al., 1993 supra), and transient hypoxia-induced neovascularization in the mouse retina (Pierce et al., 1995 Proc. Natl. Acad. Sci . USA. 92: 905-909).

The cornea model, described in Pandey et al. supra, is the most common and well characterized anti-angiogenic agent efficacy screening model. This model involves an avascular tissue into which vessels are recruited by a stimulating agent (growth factor, thermal or alkalai burn, endotoxin). The corneal model would utilize the intrastromal corneal implantation of a Teflon pellet soaked in a VEGF-Hydron solution to recruit blood vessels toward the pellet which can be quantitated using standard microscopic and image analysis techniques. To evaluate their anti-angiogenic efficacy, ribozymes are applied topically to the eye or bound within Hydron on the Teflon pellet itself. This avascular cornea as well as the Matrigel (see below) provide for low background assays. While the corneal model has been performed extensively in the rabbit, studies in the rat have also been conducted.

The mouse model (Passaniti et al. supra) is a non-tissue model which utilizes Matrigel, an extract of basement membrane (Kleinman et al., 1986) or Millipore® filter disk, which can be impregnated wvith growth factors and anti-angiogenic agents in a liquid form prior to injection. Upon subcutaneous administration at body temperature, the Matrigel or Millipore® filter disk forms a solid implant. VEGF embedded in the Matrigel or Millipore® filter disk would be used to recruit vessels within the matrix of the Matrigel or Millipore® filter disk which can be processed histologically for endothelial cell specific vWF (factor VIII antigen) immunohistochemistry, Trichrome-Masson stain, or hemoglobin content. Like the cornea, the Matrigel or Millipore® filter disk are avascular; however, it is not tissue. In the Matrigel or Millipore® filter disk model, ribozymes are administered within the matrix of the Matrigel or Millipore® filter disk to test their anti-angiogenic efficacy. Thus, delivery issues in this model, as with delivery of ribozymes by Hydron-coated Teflon pellets in the rat cornea model, may be less problematic due to the homogeneous presence of the ribozyme within the respective matrix.

These models offer a distinct advantage over several other angiogenic models listed previously. The ability to use VEGF as a pro-angiogenic stimulus in both models is highly desirable since ribozymes will target only VEGFr mRNA. In other words, the involvement of other non-specific types of stimuli in the cornea and Matrigel models is not advantageous from the standpoint of understanding the pharmacologic mechanism by which the anti-VEGFr mRNA ribozymes produce their effects. In addition, the models will allow for testing the specificity of the anti-VEGFr mRNA ribozymes by using either a- or bFGF as a pro-angiogenic factor. Vessel recruitment using FGF should not be affected in either model by anti-VEGFr mRNA ribozymes. Other models of angiogenesis including vessel formation in the female reproductive system using hormonal manipulation (Shweiki et al., 1993 supra); a variety of vascular solid tumor models which involve indirect correltations with angiogenesis (O'Reilly et al., 1994 supra; Senger et al., 1993 supra; Takahasi et al., 1994 supra; Kim et al., 1993 supra); and retinal neovascularization following transient hypoxia (Pierce et al., 1995 supra) were not selected for efficacy screening due to their non-specific nature, although there is a correlation between VEGF and angiogenesis in these models.

Other model systems to study tumor angiogenesis is reviewed by Folkman, 1985 Adv. Cancer. Res., 43, 175.

flt-1, KDR and/or flk-1 protein levels can be measured clinically or experimentally by FACS analysis. flt-1, KDR and/or flk-1 encoded mRNA levels will be assessed by Northern analysis, RNase-protection, primer extension analysis and/or quantitative RT-PCR. Ribozymes that block flt-1, KDR and/or flk-1 protein encoding mRNAs and therefore result in decreased levels of flt-1, KDR and/or flk-1 activity by more than 20% in vitro will be identified.

Ribozymes and/or genes encoding them are delivered by either free delivery, liposome delivery, cationic lipid delivery, adeno-associated virus vector delivery, adenovirus vector delivery, retrovirus vector delivery or plasmid vector delivery in these animal model experiments (see above).

Patients can be treated by locally administering nucleic acids targeted against VEGF−R by direct injection. Routes of administration may include, but are not limited to, intravascular, intramuscular, subcutaneous, intraarticular, aerosol inhalation, oral (tablet, capsule or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery.

EXAMPLE 11

Ribozyme-mediated Inhibition of Angiogenesis In vivo

The purpose of this study was to assess the anti-angiogenic activity of hammerhead ribozymes targeted against flt-1 4229 site in the rat cornea model of VEGF induced angiogenesis (see above). These ribozymes have either active or inactive catalytic core and either bind and cleave or just bind to VEGF−R mRNA of the flt-1 subtype. The active ribozymes, that are able to bind and cleave the target RNA, have been shown to inhibit ( 125 I-labeled) VEGF binding in cultured endothelial cells and produce a dose-dependent decrease in VEGF induced endothelial cell proliferation in these cells (see Examples 3-5 above). The catalytically inactive forms of these ribozymes, wherein the ribozymes can only bind to the RNA but cannot catalyze RNA cleavage, fail to show these characteristics. The ribozymes and VEGF were co-delivered using the filter disk method: Nitrocellulose filter disks (Millipore®) of 0.057 diameter were immersed in appropriate solutions and were surgically implanted in rat cornea as described by Pandey et al., supra. This delivery method has been shown to deliver rhodamine-labeled free ribozyme to scleral cells and, in all likelihood cells of the pericorneal vascular plexus. Since the active ribozymes show cell culture efficacy and can be delivered to the target site using the disk method, it is essential that these ribozymes be assessed for in vivo anti-angiogenic activity.

The stimulus for angiogenesis in this study was the treatment of the filter disk with 30 μM VEGF which is implanted within the cornea's stroma. This dose yields reproducible neovascularization stemming from the pericorneal vascular plexus growing toward the disk in a dose-response study 5 days following implant. Filter disks treated only with the vehicle for VEGF show no angiogenic response. The ribozymes was co-adminstered with VEGF on a disk in two different ribozyme concentrations. One concern with the simultaneous administration is that the ribozymes will not be able to inhibit angiogenesis since VEGF receptors can be stimulated. However, we have observed that in low VEGF doses, the neovascular response reverts to normal suggesting that the VEGF stimulus is essential for maintaining the angiogenic response. Blocking the production of VEGF receptors using simultaneous administration of anti-VEGF−R mRNA ribozymes could attenuate the normal neovascularization induced by the filter disk treated with VEGF.

MATERIALS AND METHODS

1. Stock Hammerhead Ribozyme Solutions

a. flt-1 4229 (786 μM)—Active

b. flt-1 4229 (736 μM)—Inactive

2. Experimantal Solutions/groups

Group 1	Solution 1	Control VEGF solution: 30 μM in 82 mM Tris base
Group 2	Solution 2	flt-1 4229 (1 μg/μL) in 30 μM VEGF/82 mM Tris
		base
Group 3	Solution 3	flt-1 4229 (10 μg/μL) in 30 μM VEGF/82 mM Tris
		base
Group 4	Solution 4	No VEGF, flt-1 4229 (10 μg/μL) in 82 mM Tris
		base
Group 5	Solution 5	No VEGF, No ribozyme in 82 mM Tris base

10 eyes per group, 5 animals (Since they have similar molecular weights, the molar concentrations should be essentially similar).

Each solution (VEGF and RIBOZYMES) were prepared as a 2× solution for 1:1 mixing for final concentrations above, with the exception of solution 1 in which VEGF was 2× and diluted with ribozyme diluent (sterile water).

3. VEGF Solutions

The 2×VEGF solution (60 μM) was prepared from a stock of 0.82 μg/μL in 50 mM Tris base. 200 μL of VEGF stock was concentrated by speed vac to a final volume of 60.8 μL, for a final concentration of 2.7 μg/μL or 60 μM. Six 10 μL aliquots was prepared for daily mixing. 2× solutions for VEGF and Ribozyme was stored at 4° C. until the day of the surgery. Solutions were mixed for each day of surgery. Original 2× solutions was prepared on the day before the first day of the surgery.

4. Surgical Solutions

Anesthesia

stock ketamine hydrochloride 100 mg/mL

stock xylazine hydrochloride 20 mg/mL

stock acepromazine 10 mg/mL

Final Anesthesia Solution

50 mg/mL ketamine, 10 mg/mL xylazine, and 0.5 mg/mL acepromazine

5% povidone iodine for opthalmic surgical wash

2% lidocaine (sterile) for opthalmic administration (2 drops per eye)

sterile 0.9% NaCl for opthalmic irrigation

5. Surgical Methods

Standard surgical procedure as described in Pandey et al, supra. Filter disks were incubated in 1 μL of each solution for approximately 30 minutes prior to implantation.

5. Experimental Protocol

The animal cornea were treated with the treatment groups as described above. Animals were allowed to recover for 5 days after treatment with daily observation (scoring 0-3). On the fifth day animals were euthanized and digital images of each eye was obtained for quantitaion using Image Pro Plus. Quantitated neovascular surface area were analyzed by ANOVA followed by two post-hoc tests including Dunnets and Tukey-Kramer tests for significance at the 95% confidence level. Dunnets provide information on the significance between the differences within the means of treatments vs. controls while Tukey-Kramer provide information on the significance of differences within the means of each group.

Results are graphically represented in FIG. 18 . As shown in the figure, flt-1 4229 active hammerhead ribozyme at both concentrations was effective at inhibiting angiogenesis while the inactive ribozyme did not show any significant reduction in angiogenesis. A statistically signifiant reduction in neovascular surface area was observed only with active ribozymes. This result clearly shows that the ribozymes are capable of significantly inhibiting angiogenesis in vivo. Specifically, the mechanism of inhibition appears to be by the binding and cleavage of target RNA by ribozymes.

Diagnostic Uses

Ribozymes of this invention may be used as diagnostic tools to examine genetic drift and mutations within diseased cells or to detect the presence of flt-1, KDR and/or flk-1 RNA in a cell. The close relationship between ribozyme activity and the structure of the target RNA allows the detection of mutations in any region of the molecule which alters the base-pairing and three-dimensional structure of the target RNA. By using multiple ribozymes described in this invention, one may map nucleotide changes which are important to RNA structure and function in vitro, as well as in cells and tissues. Cleavage of target RNAs with ribozymes may be used to inhibit gene expression and define the role (essentially) of specified gene products in the progression of disease. In this manner, other genetic targets may be defined as important mediators of the disease. These experiments will lead to better treatment of the disease progression by affording the possibility of combinational therapies (e.g., multiple ribozymes targeted to different genes, ribozymes coupled with known small molecule inhibitors, or intermittent treatment with combinations of ribozymes and/or other chemical or biological molecules). Other in vitro uses of ribozymes of this invention are well known in the art, and include detection of the presence of mRNAs associated with flt-1, KDR and/or flk-1 related condition. Such RNA is detected by determining the presence of a cleavage product after treatment with a ribozyme using standard methodology.

In a specific example, ribozymes which can cleave only wild-type or mutant forms of the target RNA are used for the assay. The first ribozyme is used to identify wild-type RNA present in the sample and the second ribozyme will be used to identify mutant RNA in the sample. As reaction controls, synthetic substrates of both wild-type and mutant RNA will be cleaved by both ribozymes to demonstrate the relative ribozyme efficiencies in the reactions and the absence of cleavage of the “non-targeted” RNA species. The cleavage products from the synthetic substrates will also serve to generate size markers for the analysis of wild-type and mutant RNAs in the sample population. Thus each analysis will require two ribozymes, two substrates and one unknown sample which will be combined into six reactions. The presence of cleavage products will be determined using an RNAse protection assay so that full-length and cleavage fragments of each RNA can be analyzed in one lane of a polyacrylamide gel. It is not absolutely required to quantify the results to gain insight into the expression of mutant RNAs and putative risk of the desired phenotypic changes in target cells. The expression of mRNA whose protein product is implicated in the development of the phenotype (i.e., flt-1, KDR and/or flk-1) is adequate to establish risk. If probes of comparable specific activity are used for both transcripts, then a qualitative comparison of RNA levels will be adequate and will decrease the cost of the initial diagnosis. Higher mutant form to wild-type ratios will be correlated with higher risk whether RNA levels are compared qualitatively or quantitatively.

TABLE II
Human flt1 VEGF Receptor-Hammerhead Ribozyme and Substrate
Sequence
		Seq ID		Seq ID
Pos	Substrate	No	HH Ribozyme	No
10	CGGACACUC CUCUCGGC	1	GCCGAGAG CUGAUGAG GNNNNNNNNC CGAA AGUGUCCG	4157
13	ACACUCCUC UCGGCUCC	2	GGAGCCGA CUGAUGAG GNNNNNNNNC CGAA AGGAGUGU	4158
15	ACUCCUCUC GGCUCCUC	3	GAGGAGCC CUGAUGAG GNNNNNNNNC CGAA AGAGGAGU	4159
20	UCUCGGCUC CUCCCCGG	4	CCGGGGAG CUGAUGAG GNNNNNNNNC CGAA AGCCGAGA	4160
23	CGGCUCCUC CCCGGCAG	5	CUGCCGGG CUGAUGAG GNNNNNNNNC CGAA AGGAGCCG	4161
43	CGGCGGCUC GGAGCGGG	6	CCCGCUCC CUGAUGAG GNNNNNNNNC CGAA AGCCGCCG	4162
54	AGCGGGCUC CGGGGCUC	7	GAGCCCCG CUGAUGAG GNNNNNNNNC CGAA AGCCCGCU	4163
62	CCGGGGCUC GGGUGCAG	8	CUGCACCC CUGAUGAG GNNNNNNNNC CGAA AGCCCCGG	4164
97	GCGAGGAUU ACCCGGGG	9	CCCCGGGU CUGAUGAG GNNNNNNNNC CGAA AUCCUCGC	4165
98	CGAGGAUUA CCCGGGGA	10	UCCCCGGG CUGAUGAG GNNNNNNNNC CGAA AAUCCUCG	4166
113	GAAGUGGUU GUCUCCUG	11	CAGGAGAC CUGAUGAG GNNNNNNNNC CGAA ACCACUUC	4167
116	GUGGUUGUC UCCUGGCU	12	AGCCAGGA CUGAUGAG GNNNNNNNNC CGAA ACAACCAC	4168
118	GGUUGUCUC CUGGCUGG	13	CCAGCCAG CUGAUGAG GNNNNNNNNC CGAA AGACAACC	4169
145	CGGGCGCUC AGGGCGCG	14	CGCGCCCU CUGAUGAG GNNNNNNNNC CGAA AGCGCCCG	4170
185	GACGGACUC UGGCGGCC	15	GGCCGCCA CUGAUGAG GNNNNNNNNC CGAA AGUCCGUC	4171
198	GGCCGGGUC GUUGGCCG	16	CGGCCAAC CUGAUGAG GNNNNNNNNC CGAA ACCCGGCC	4172
201	CGGGUCGUU GGCCGGGG	17	CCCCGGCC CUGAUGAG GNNNNNNNNC CGAA ACGACCCG	4173
240	GGCCGCGUC GCGCUCAC	18	GUGAGCGC CUGAUGAG GNNNNNNNNC CGAA ACGCGGCC	4174
246	GUCGCGCUC ACCAUGGU	19	ACCAUGGU CUGAUGAG GNNNNNNNNC CGAA AGCGCGAC	4175
255	ACCAUGGUC AGCUACUG	20	CAGUAGCU CUGAUGAG GNNNNNNNNC CGAA ACCAUGGU	4176
260	GGUCAGCUA CUGGGACA	21	UGUCCCAG CUGAUGAG GNNNNNNNNC CGAA AGCUGACC	4177
276	ACCGGGGUC CUGCUGUG	22	CACAGCAG CUGAUGAG GNNNNNNNNC CGAA ACCCCGGU	4178
294	GCGCUGCUC AGCUGUCU	23	AGACAGCU CUGAUGAG GNNNNNNNNC CGAA AGCAGCGC	4179
301	UCAGCUGUC UGCUUCUC	24	GAGAAGCA CUGAUGAG GNNNNNNNNC CGAA ACAGCUGA	4180
306	UGUCUGCUU CUCACAGG	25	CCUGUGAG CUGAUGAG GNNNNNNNNC CGAA AGCAGACA	4181
307	GUCUGCUUC UCACAGGA	26	UCCUGUGA CUGAUGAG GNNNNNNNNC CGAA AAGCAGAC	4182
309	CUGCUUCUC ACAGGAUC	27	GAUCCUGU CUGAUGAG GNNNNNNNNC CGAA AGAAGCAG	4183
317	CACAGGAUC UAGUUCAG	28	CUGAACUA CUGAUGAG GNNNNNNNNC CGAA AUCCUGUG	4184
319	CAGGAUCUA GUUCAGGU	29	ACCUGAAC CUGAUGAG GNNNNNNNNC CGAA AGAUCCUG	4185
322	GAUCUAGUU CAGGUUCA	30	UGAACCUG CUGAUGAG GNNNNNNNNC CGAA ACUAGAUC	4186
323	AUCUAGUUC AGGUUCAA	31	UUGAACCU CUGAUGAG GNNNNNNNNC CGAA AACUAGAU	4187
328	GUUCAGGUU CAAAAUUA	32	UAAUUUUG CUGAUGAG GNNNNNNNNC CGAA ACCUGAAC	4188
329	UUCAGGUUC AAAAUUAA	33	UUAAUUUU CUGAUGAG GNNNNNNNNC CGAA AACCUGAA	4189
335	UUCAAAAUU AAAAGAUC	34	GAUCUUUU CUGAUGAG GNNNNNNNNC CGAA AUUUUGAA	4190
336	UCAAAAUUA AAAGAUCC	35	GGAUCUUU CUGAUGAG GNNNNNNNNC CGAA AAUUUUGA	4191
343	UAAAAGAUC CUGAACUG	36	CAGUUCAG CUGAUGAG GNNNNNNNNC CGAA AUCUUUUA	4192
355	AACUGAGUU UAAAAGGC	37	GCCUUUUA CUGAUGAG GNNNNNNNNC CGAA ACUCAGUU	4193
356	ACUGAGUUU AAAAGGCA	38	UGCCUUUU CUGAUGAG GNNNNNNNNC CGAA AACUCAGU	4194
357	CUGAGUUUA AAAGGCAC	39	GUGCCUUU CUGAUGAG GNNNNNNNNC CGAA AAACUCAG	4195
375	CAGCACAUC AUGCAAGC	40	GCUUGCAU CUGAUGAG GNNNNNNNNC CGAA AUGUGCUG	4196
400	CACUGCAUC UCCAAUGC	41	GCAUUGGA CUGAUGAG GNNNNNNNNC CGAA AUGCAGUG	4197
402	CUGCAUCUC CAAUGCAG	42	CUGCAUUG CUGAUGAG GNNNNNNNNC CGAA AGAUGCAG	4198
427	CAGCCCAUA AAUGGUCU	43	AGACCAUU CUGAUGAG GNNNNNNNNC CGAA AUGGGCUG	4199
434	UAAAUGGUC UUUGCCUG	44	CAGGCAAA CUGAUGAG GNNNNNNNNC CGAA ACCAUUUA	4200
436	AAUGGUCUU UGCCUGAA	45	UUCAGGCA CUGAUGAG GNNNNNNNNC CGAA AGACCAUU	4201
437	AUGGUCUUU GCCUGAAA	46	UUUCAGGC CUGAUGAG GNNNNNNNNC CGAA AAGACCAU	4202
454	UGGUGAGUA AGGAAAGC	47	GCUUUCCU CUGAUGAG GNNNNNNNNC CGAA ACUCACCA	4203
477	CUGAGCAUA ACUAAAUC	48	GAUUUAGU CUGAUGAG GNNNNNNNNC CGAA AUGCUCAG	4204
481	GCAUAACUA AAUCUGCC	49	GGCAGAUU CUGAUGAG GNNNNNNNNC CGAA AGUUAUGC	4205
485	AACUAAAUC UGCCUGUG	50	CACAGGCA CUGAUGAG GNNNNNNNNC CGAA AUUUAGUU	4206
512	CAAACAAUU CUGCAGUA	51	UACUGCAG CUGAUGAG GNNNNNNNNC CGAA AUUGUUUG	4207
513	AAACAAUUC UGCAGUAC	52	GUACUGCA CUGAUGAG GNNNNNNNNC CGAA AAUUGUUU	4208
520	UCUGCAGUA CUUUAACC	53	GGUUAAAG CUGAUGAG GNNNNNNNNC CGAA ACUGCAGA	4209
523	GCAGUACUU UAACCUUG	54	CAAGGUUA CUGAUGAG GNNNNNNNNC CGAA AGUACUGC	4210
524	CAGUACUUU AACCUUGA	55	UCAAGGUU CUGAUGAG GNNNNNNNNC CGAA AAGUACUG	4211
525	AGUACUUUA ACCUUGAA	56	UUCAAGGU CUGAUGAG GNNNNNNNNC CGAA AAAGUACU	4212
530	UUUAACCUU GAACACAG	57	CUGUGUUC CUGAUGAG GNNNNNNNNC CGAA AGGUUAAA	4213
541	ACACAGCUC AAGCAAAC	58	GUUUGCUU CUGAUGAG GNNNNNNNNC CGAA AGCUGUGU	4214
560	CACUGGCUU CUACAGCU	59	AGCUGUAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGUG	4215
561	ACUGGCUUC UACAGCUG	60	CAGCUGUA CUGAUGAG GNNNNNNNNC CGAA AAGCCAGU	4216
563	UGGCUUCUA CAGCUGCA	61	UGCAGCUG CUGAUGAG GNNNNNNNNC CGAA AGAAGCCA	4217
575	CUGCAAAUA UCUAGCUG	62	CAGCUAGA CUGAUGAG GNNNNNNNNC CGAA AUUUGCAG	4218
577	GCAAAUAUC UAGCUGUA	63	UACAGCUA CUGAUGAG GNNNNNNNNC CGAA AUAUUUGC	4219
579	AAAUAUCUA GCUGUACC	64	GGUACAGC CUGAUGAG GNNNNNNNNC CGAA AGAUAUUU	4220
585	CUAGCUGUA CCUACUUC	65	GAAGUAGG CUGAUGAG GNNNNNNNNC CGAA ACAGCUAG	4221
589	CUGUACCUA CUUCAAAG	66	CUUUGAAG CUGAUGAG GNNNNNNNNC CGAA AGGUACAG	4222
592	UACCUACUU CAAAGAAG	67	CUUCUUUG CUGAUGAG GNNNNNNNNC CGAA AGUAGGUA	4223
593	ACCUACUUC AAAGAAGA	68	UCUUCUUU CUGAUGAG GNNNNNNNNC CGAA AAGUAGGU	4224
614	AACAGAAUC UGCAAUCU	69	AGAUUGCA CUGAUGAG GNNNNNNNNC CGAA AUUCUGUU	4225
621	UCUGCAAUC UAUAUAUU	70	AAUAUAUA CUGAUGAG GNNNNNNNNC CGAA AUUGCAGA	4226
623	UGCAAUCUA UAUAUUUA	71	UAAAUAUA CUGAUGAG GNNNNNNNNC CGAA AGAUUGCA	4227
625	CAAUCUAUA UAUUUAUU	72	AAUAAAUA CUGAUGAG GNNNNNNNNC CGAA AUAGAUUG	4228
627	AUCUAUAUA UUUAUUAG	73	CUAAUAAA CUGAUGAG GNNNNNNNNC CGAA AUAUAGAU	4229
629	CUAUAUAUU UAUUAGUG	74	CACUAAUA CUGAUGAG GNNNNNNNNC CGAA AUAUAUAG	4230
630	UAUAUAUUU AUUAGUGA	75	UCACUAAU CUGAUGAG GNNNNNNNNC CGAA AAUAUAUA	4231
631	AUAUAUUUA UUAGUGAU	76	AUCACUAA CUGAUGAG GNNNNNNNNC CGAA AAAUAUAU	4232
633	AUAUUUAUU AGUGAUAC	77	GUAUCACU CUGAUGAG GNNNNNNNNC CGAA AUAAAUAU	4233
634	UAUUUAUUA GUGAUACA	78	UGUAUCAC CUGAUGAG GNNNNNNNNC CGAA AAUAAAUA	4234
640	UUAGUGAUA CAGGUAGA	79	UCUACCUG CUGAUGAG GNNNNNNNNC CGAA AUCACUAA	4235
646	AUACAGGUA GACCUUUC	80	GAAAGGUC CUGAUGAG GNNNNNNNNC CGAA ACCUGUAU	4236
652	GUAGACCUU UCGUAGAG	81	CUCUACGA CUGAUGAG GNNNNNNNNC CGAA AGGUCUAC	4237
653	UAGACCUUU CGUAGAGA	82	UCUCUACG CUGAUGAG GNNNNNNNNC CGAA AAGGUCUA	4238
654	AGACCUUUC GUAGAGAU	83	AUCUCUAC CUGAUGAG GNNNNNNNNC CGAA AAAGGUCU	4239
657	CCUUUCGUA GAGAUGUA	84	UACAUCUC CUGAUGAG GNNNNNNNNC CGAA ACGAAAGG	4240
665	AGAGAUGUA CAGUGAAA	85	UUUCACUG CUGAUGAG GNNNNNNNNC CGAA ACAUCUCU	4241
675	AGUGAAAUC CCCGAAAU	86	AUUUCGGG CUGAUGAG GNNNNNNNNC CGAA AUUUCACU	4242
684	CCCGAAAUU AUACACAU	87	AUGUGUAU CUGAUGAG GNNNNNNNNC CGAA AUUUCGGG	4243
685	CCGAAAUUA UACACAUG	88	CAUGUGUA CUGAUGAG GNNNNNNNNC CGAA AAUUUCGG	4244
687	GAAAUUAUA CACAUGAC	89	GUCAUGUG CUGAUGAG GNNNNNNNNC CGAA AUAAUUUC	4245
711	AGGGAGCUC GUCAUUCC	90	GGAAUGAC CUGAUGAG GNNNNNNNNC CGAA AGCUCCCU	4246
714	GAGCUCGUC AUUCCCUG	91	CAGGGAAU CUGAUGAG GNNNNNNNNC CGAA ACGAGCUC	4247
717	CUCGUCAUU CCCUGCCG	92	CGGCAGGG CUGAUGAG GNNNNNNNNC CGAA AUGACGAG	4248
718	UCGUCAUUC CCUGCCGG	93	CCGGCAGG CUGAUGAG GNNNNNNNNC CGAA AAUGACGA	4249
729	UGCCGGGUU ACGUCACC	94	GGUGACGU CUGAUGAG GNNNNNNNNC CGAA ACCCGGCA	4250
730	GCCGGGUUA CGUCACCU	95	AGGUGACG CUGAUGAG GNNNNNNNNC CGAA AACCCGGC	4251
734	GGUUACGUC ACCUAACA	96	UGUUAGGU CUGAUGAG GNNNNNNNNC CGAA ACGUAACC	4252
739	CGUCACCUA ACAUCACU	97	AGUGAUGU CUGAUGAG GNNNNNNNNC CGAA AGGUGACG	4253
744	CCUAACAUC ACUGUUAC	98	GUAACAGU CUGAUGAG GNNNNNNNNC CGAA AUGUUAGG	4254
750	AUCACUGUU ACUUUAAA	99	UUUAAAGU CUGAUGAG GNNNNNNNNC CGAA ACAGUGAU	4255
751	UCACUGUUA CUUUAAAA	100	UUUUAAAG CUGAUGAG GNNNNNNNNC CGAA AACAGUGA	4256
754	CUGUUACUU UAAAAAAG	101	CUUUUUUA CUGAUGAG GNNNNNNNNC CGAA AGUAACAG	4257
755	UGUUACUUU AAAAAAGU	102	ACUUUUUU CUGAUGAG GNNNNNNNNC CGAA AAGUAACA	4258
756	GUUACUUUA AAAAAGUU	103	AACUUUUU CUGAUGAG GNNNNNNNNC CGAA AAAGUAAC	4259
764	AAAAAAGUU UCCACUUG	104	CAAGUGGA CUGAUGAG GNNNNNNNNC CGAA ACUUUUUU	4260
765	AAAAAGUUU CCACUUGA	105	UCAAGUGG CUGAUGAG GNNNNNNNNC CGAA AACUUUUU	4261
766	AAAAGUUUC CACUUGAC	106	GUCAAGUG CUGAUGAG GNNNNNNNNC CGAA AAACUUUU	4262
771	UUUCCACUU GACACUUU	107	AAAGUGUC CUGAUGAG GNNNNNNNNC CGAA AGUGGAAA	4263
778	UUGACACUU UGAUCCCU	108	AGGGAUCA CUGAUGAG GNNNNNNNNC CGAA AGUGUCAA	4264
779	UGACACUUU GAUCCCUG	109	CAGGGAUC CUGAUGAG GNNNNNNNNC CGAA AAGUGUCA	4265
783	ACUUUGAUC CCUGAUGG	110	CCAUCAGG CUGAUGAG GNNNNNNNNC CGAA AUCAAAGU	4266
801	AAACGCAUA AUCUGGGA	111	UCCCAGAU CUGAUGAG GNNNNNNNNC CGAA AUGCGUUU	4267
804	CGCAUAAUC UGGGACAG	112	CUGUCCCA CUGAUGAG GNNNNNNNNC CGAA AUUAUGCG	4268
814	GGGACAGUA GAAAGGGC	113	GCCCUUUC CUGAUGAG GNNNNNNNNC CGAA ACUGUCCC	4269
824	AAAGGGCUU CAUCAUAU	114	AUAUGAUG CUGAUGAG GNNNNNNNNC CGAA AGCCCUUU	4270
825	AAGGGCUUC AUCAUAUC	115	GAUAUGAU CUGAUGAG GNNNNNNNNC CGAA AAGCCCUU	4271
828	GGCUUCAUC AUAUCAAA	116	UUUGAUAU CUGAUGAG GNNNNNNNNC CGAA AUGAAGCC	4272
831	UUCAUCAUA UCAAAUGC	117	GCAUUUGA CUGAUGAG GNNNNNNNNC CGAA AUGAUGAA	4273
833	CAUCAUAUC AAAUGCAA	118	UUGCAUUU CUGAUGAG GNNNNNNNNC CGAA AUAUGAUG	4274
845	UGCAACGUA CAAAGAAA	119	UUUCUUUG CUGAUGAG GNNNNNNNNC CGAA ACGUUGCA	4275
855	AAAGAAAUA GGGCUUCU	120	AGAAGCCC CUGAUGAG GNNNNNNNNC CGAA AUUUCUUU	4276
861	AUAGGGCUU CUGACCUG	121	CAGGUCAG CUGAUGAG GNNNNNNNNC CGAA AGCCCUAU	4277
862	UAGGGCUUC UGACCUGU	122	ACAGGUCA CUGAUGAG GNNNNNNNNC CGAA AAGCCCUA	4278
882	GCAACAGUC AAUGGGCA	123	UGCCCAUU CUGAUGAG GNNNNNNNNC CGAA ACUGUUGC	4279
892	AUGGGCAUU UGUAUAAG	124	CUUAUACA CUGAUGAG GNNNNNNNNC CGAA AUGCCCAU	4280
893	UGGGCAUUU GUAUAAGA	125	UCUUAUAC CUGAUGAG GNNNNNNNNC CGAA AAUGCCCA	4281
896	GCAUUUGUA UAAGACAA	126	UUGUCUUA CUGAUGAG GNNNNNNNNC CGAA ACAAAUGC	4282
898	AUUUGUAUA AGACAAAC	127	GUUUGUCU CUGAUGAG GNNNNNNNNC CGAA AUACAAAU	4283
908	GACAAACUA UCUCACAC	128	GUGUGAGA CUGAUGAG GNNNNNNNNC CGAA AGUUUGUC	4284
910	CAAACUAUC UCACACAU	129	AUGUGUGA CUGAUGAG GNNNNNNNNC CGAA AUAGUUUG	4285
912	AACUAUCUC ACACAUCG	130	CGAUGUGU CUGAUGAG GNNNNNNNNC CGAA AGAUAGUU	4286
919	UCACACAUC GACAAACC	131	GGUUUGUC CUGAUGAG GNNNNNNNNC CGAA AUGUGUGA	4287
931	AAACCAAUA CAAUCAUA	132	UAUGAUUG CUGAUGAG GNNNNNNNNC CGAA AUUGGUUU	4288
936	AAUACAAUC AUAGAUGU	133	ACAUCUAU CUGAUGAG GNNNNNNNNC CGAA AUUGUAUU	4289
939	ACAAUCAUA GAUGUCCA	134	UGGACAUC CUGAUGAG GNNNNNNNNC CGAA AUGAUUGU	4290
945	AUAGAUGUC CAAAUAAG	135	CUUAUUUG CUGAUGAG GNNNNNNNNC CGAA ACAUCUAU	4291
951	GUCCAAAUA AGCACACC	136	GGUGUGCU CUGAUGAG GNNNNNNNNC CGAA AUUUGGAC	4292
969	CGCCCAGUC AAAUUACU	137	AGUAAUUU CUGAUGAG GNNNNNNNNC CGAA ACUGGGCG	4293
974	AGUCAAAUU ACUUAGAG	138	CUCUAAGU CUGAUGAG GNNNNNNNNC CGAA AUUUGACU	4294
975	GUCAAAUUA CUUAGAGG	139	CCUCUAAG CUGAUGAG GNNNNNNNNC CGAA AAUUUGAC	4295
978	AAAUUACUU AGAGGCCA	140	UGGCCUCU CUGAUGAG GNNNNNNNNC CGAA AGUAAUUU	4296
979	AAUUACUUA GAGGCCAU	141	AUGGCCUC CUGAUGAG GNNNNNNNNC CGAA AAGUAAUU	4297
988	GAGGCCAUA CUCUUGUC	142	GACAAGAG CUGAUGAG GNNNNNNNNC CGAA AUGGCCUC	4298
991	GCCAUACUC UUGUCCUC	143	GAGGACAA CUGAUGAG GNNNNNNNNC CGAA AGUAUGGC	4299
993	CAUACUCUU GUCCUCAA	144	UUGAGGAC CUGAUGAG GNNNNNNNNC CGAA AGAGUAUG	4300
996	ACUCUUGUC CUCAAUUG	145	CAAUUGAG CUGAUGAG GNNNNNNNNC CGAA ACAAGAGU	4301
999	CUUGUCCUC AAUUGUAC	146	GUACAAUU CUGAUGAG GNNNNNNNNC CGAA AGGACAAG	4302
1003	UCCUCAAUU GUACUGCU	147	AGCAGUAC CUGAUGAG GNNNNNNNNC CGAA AUUGAGGA	4303
1006	UCAAUUGUA CUGCUACC	148	GGUAGCAG CUGAUGAG GNNNNNNNNC CGAA ACAAUUGA	4304
1012	GUACUGCUA CCACUCCC	149	GGGAGUGG CUGAUGAG GNNNNNNNNC CGAA AGCAGUAC	4305
1018	CUACCACUC CCUUGAAC	150	GUUCAAGG CUGAUGAG GNNNNNNNNC CGAA AGUGGUAG	4306
1022	CACUCCCUU GAACACGA	151	UCGUGUUC CUGAUGAG GNNNNNNNNC CGAA AGGGAGUG	4307
1035	ACGAGAGUU CAAAUGAC	152	GUCAUUUG CUGAUGAG GNNNNNNNNC CGAA ACUCUCGU	4308
1036	CGAGAGUUC AAAUGACC	153	GGUCAUUU CUGAUGAG GNNNNNNNNC CGAA AACUCUCG	4309
1051	CCUGGAGUU ACCCUGAU	154	AUCAGGGU CUGAUGAG GNNNNNNNNC CGAA ACUCCAGG	4310
1052	CUGGAGUUA CCCUGAUG	155	CAUCAGGG CUGAUGAG GNNNNNNNNC CGAA AACUCCAG	4311
1069	AAAAAAAUA AGAGAGCU	156	AGCUCUCU CUGAUGAG GNNNNNNNNC CGAA AUUUUUUU	4312
1078	AGAGAGCUU CCGUAAGG	157	CCUUACGG CUGAUGAG GNNNNNNNNC CGAA AGCUCUCU	4313
1079	GAGAGCUUC CGUAAGGC	158	GCCUUACG CUGAUGAG GNNNNNNNNC CGAA AAGCUCUC	4314
1083	GCUUCCGUA AGGCGACG	159	CGUCGCCU CUGAUGAG GNNNNNNNNC CGAA ACGGAAGC	4315
1095	CGACGAAUU GACCAAAG	160	CUUUGGUC CUGAUGAG GNNNNNNNNC CGAA AUUCGUCG	4316
1108	AAAGCAAUU CCCAUGCC	161	GGCAUGGG CUGAUGAG GNNNNNNNNC CGAA AUUGCUUU	4317
1109	AAGCAAUUC CCAUGCCA	162	UGGCAUGG CUGAUGAG GNNNNNNNNC CGAA AAUUGCUU	4318
1122	GCCAACAUA UUCUACAG	163	CUGUAGAA CUGAUGAG GNNNNNNNNC CGAA AUGUUGGC	4319
1124	CAACAUAUU CUACAGUG	164	CACUGUAG CUGAUGAG GNNNNNNNNC CGAA AUAUGUUG	4320
1125	AACAUAUUC UACAGUGU	165	ACACUGUA CUGAUGAG GNNNNNNNNC CGAA AAUAUGUU	4321
1127	CAUAUUCUA CAGUGUUC	166	GAACACUG CUGAUGAG GNNNNNNNNC CGAA AGAAUAUG	4322
1134	UACAGUGUU CUUACUAU	167	AUAGUAAG CUGAUGAG GNNNNNNNNC CGAA ACACUGUA	4323
1135	ACAGUGUUC UUACUAUU	168	AAUAGUAA CUGAUGAG GNNNNNNNNC CGAA AACACUGU	4324
1137	AGUGUUCUU ACUAUUGA	169	UCAAUAGU CUGAUGAG GNNNNNNNNC CGAA AGAACACU	4325
1138	GUGUUCUUA CUAUUGAC	170	GUCAAUAG CUGAUGAG GNNNNNNNNC CGAA AAGAACAC	4326
1141	UUCUUACUA UUGACAAA	171	UUUGUCAA CUGAUGAG GNNNNNNNNC CGAA AGUAAGAA	4327
1143	CUUACUAUU GACAAAAU	172	AUUUUGUC CUGAUGAG GNNNNNNNNC CGAA AUAGUAAG	4328
1173	AAAGGACUU UAUACUUG	173	CAAGUAUA CUGAUGAG GNNNNNNNNC CGAA AGUCCUUU	4329
1174	AAGGACUUU AUACUUGU	174	ACAAGUAU CUGAUGAG GNNNNNNNNC CGAA AAGUCCUU	4330
1175	AGGACUUUA UACUUGUC	175	GACAAGUA CUGAUGAG GNNNNNNNNC CGAA AAAGUCCU	4331
1177	GACUUUAUA CUUGUCGU	176	ACGACAAG CUGAUGAG GNNNNNNNNC CGAA AUAAAGUC	4332
1180	UUUAUACUU GUCGUGUA	177	UACACGAC CUGAUGAG GNNNNNNNNC CGAA AGUAUAAA	4333
1183	AUACUUGUC GUGUAAGG	178	CCUUACAC CUGAUGAG GNNNNNNNNC CGAA ACAAGUAU	4334
1188	UGUCGUGUA AGGAGUGG	179	CCACUCCU CUGAUGAG GNNNNNNNNC CGAA ACACGACA	4335
1202	UGGACCAUC AUUCAAAU	180	AUUUGAAU CUGAUGAG GNNNNNNNNC CGAA AUGGUCCA	4336
1205	ACCAUCAUU CAAAUCUG	181	CAGAUUUG CUGAUGAG GNNNNNNNNC CGAA AUGAUGGU	4337
1206	CCAUCAUUC AAAUCUGU	182	ACAGAUUU CUGAUGAG GNNNNNNNNC CGAA AAUGAUGG	4338
1211	AUUCAAAUC UGUUAACA	183	UGUUAACA CUGAUGAG GNNNNNNNNC CGAA AUUUGAAU	4339
1215	AAAUCUGUU AACACCUC	184	GAGGUGUU CUGAUGAG GNNNNNNNNC CGAA ACAGAUUU	4340
1216	AAUCUGUUA ACACCUCA	185	UGAGGUGU CUGAUGAG GNNNNNNNNC CGAA AACAGAUU	4341
1223	UAACACCUC AGUGCAUA	186	UAUGCACU CUGAUGAG GNNNNNNNNC CGAA AGGUGUUA	4342
1231	CAGUGCAUA UAUAUGAU	187	AUCAUAUA CUGAUGAG GNNNNNNNNC CGAA AUGCACUG	4343
1233	GUGCAUAUA UAUGAUAA	188	UUAUCAUA CUGAUGAG GNNNNNNNNC CGAA AUAUGCAC	4344
1235	GCAUAUAUA UGAUAAAG	189	CUUUAUCA CUGAUGAG GNNNNNNNNC CGAA AUAUAUGC	4345
1240	UAUAUGAUA AAGCAUUC	190	GAAUGCUU CUGAUGAG GNNNNNNNNC CGAA AUCAUAUA	4346
1247	UAAAGCAUU CAUCACUG	191	CAGUGAUG CUGAUGAG GNNNNNNNNC CGAA AUGCUUUA	4347
1248	AAAGCAUUC AUCACUGU	192	ACAGUGAU CUGAUGAG GNNNNNNNNC CGAA AAUGCUUU	4348
1251	GCAUUCAUC ACUGUGAA	193	UUCACAGU CUGAUGAG GNNNNNNNNC CGAA AUGAAUGC	4349
1264	UGAAACAUC GAAAACAG	194	CUGUUUUC CUGAUGAG GNNNNNNNNC CGAA AUGUUUCA	4350
1281	CAGGUGCUU GAAACCGU	195	ACGGUUUC CUGAUGAG GNNNNNNNNC CGAA AGCACCUG	4351
1290	GAAACCGUA GCUGGCAA	196	UUGCCAGC CUGAUGAG GNNNNNNNNC CGAA ACGGUUUC	4352
1304	CAAGCGGUC UUACCGGC	197	GCCGGUAA CUGAUGAG GNNNNNNNNC CGAA ACCGCUUG	4353
1306	AGCGGUCUU ACCGGCUC	198	GAGCCGGU CUGAUGAG GNNNNNNNNC CGAA AGACCGCU	4354
1307	GCGGUCUUA CCGGCUCU	199	AGAGCCGG CUGAUGAG GNNNNNNNNC CGAA AAGACCGC	4355
1314	UACCGGCUC UCUAUGAA	200	UUCAUAGA CUGAUGAG GNNNNNNNNC CGAA AGCCGGUA	4356
1316	CCGGCUCUC UAUGAAAG	201	CUUUCAUA CUGAUGAG GNNNNNNNNC CGAA AGAGCCGG	4357
1318	GGCUCUCUA UGAAAGUG	202	CACUUUCA CUGAUGAG GNNNNNNNNC CGAA AGAGAGCC	4358
1334	GAAGGCAUU UCCCUCGC	203	GCGAGGGA CUGAUGAG GNNNNNNNNC CGAA AUGCCUUC	4359
1335	AAGGCAUUU CCCUCGCC	204	GGCGAGGG CUGAUGAG GNNNNNNNNC CGAA AAUGCCUU	4360
1336	AGGCAUUUC CCUCGCCG	205	CGGCGAGG CUGAUGAG GNNNNNNNNC CGAA AAAUGCCU	4361
1340	AUUUCCCUC GCCGGAAG	206	CUUCCGGC CUGAUGAG GNNNNNNNNC CGAA AGGGAAAU	4362
1350	CCGGAAGUU GUAUGGUU	207	AACCAUAC CUGAUGAG GNNNNNNNNC CGAA ACUUCCGG	4363
1353	GAAGUUGUA UGGUUAAA	208	UUUAACCA CUGAUGAG GNNNNNNNNC CGAA ACAACUUC	4364
1358	UGUAUGGUU AAAAGAUG	209	CAUCUUUU CUGAUGAG GNNNNNNNNC CGAA ACCAUACA	4365
1359	GUAUGGUUA AAAGAUGG	210	CCAUCUUU CUGAUGAG GNNNNNNNNC CGAA AACCAUAC	4366
1370	AGAUGGGUU ACCUGCGA	211	UCGCAGGU CUGAUGAG GNNNNNNNNC CGAA ACCCAUCU	4367
1371	GAUGGGUUA CCUGCGAC	212	GUCGCAGG CUGAUGAG GNNNNNNNNC CGAA AACCCAUC	4368
1388	UGAGAAAUC UGCUCGCU	213	AGCGAGCA CUGAUGAG GNNNNNNNNC CGAA AUUUCUCA	4369
1393	AAUCUGCUC GCUAUUUG	214	CAAAUAGC CUGAUGAG GNNNNNNNNC CGAA AGCAGAUU	4370
1397	UGCUCGCUA UUUGACUC	215	GAGUCAAA CUGAUGAG GNNNNNNNNC CGAA AGCGAGCA	4371
1399	CUCGCUAUU UGACUCGU	216	ACGAGUCA CUGAUGAG GNNNNNNNNC CGAA AUAGCGAG	4372
1400	UCGCUAUUU GACUCGUG	217	CACGAGUC CUGAUGAG GNNNNNNNNC CGAA AAUAGCGA	4373
1405	AUUUGACUC GUGGCUAC	218	GUAGCCAC CUGAUGAG GNNNNNNNNC CGAA AGUCAAAU	4374
1412	UCGUGGCUA CUCGUUAA	219	UUAACGAG CUGAUGAG GNNNNNNNNC CGAA AGCCACGA	4375
1415	UGGCUACUC GUUAAUUA	220	UAAUUAAC CUGAUGAG GNNNNNNNNC CGAA AGUAGCCA	4376
1418	CUACUCGUU AAUUAUCA	221	UGAUAAUU CUGAUGAG GNNNNNNNNC CGAA ACGAGUAG	4377
1419	UACUCGUUA AUUAUCAA	222	UUGAUAAU CUGAUGAG GNNNNNNNNC CGAA AACGAGUA	4378
1422	UCGUUAAUU AUCAAGGA	223	UCCUUGAU CUGAUGAG GNNNNNNNNC CGAA AUUAACGA	4379
1423	CGUUAAUUA UCAAGGAC	224	GUCCUUGA CUGAUGAG GNNNNNNNNC CGAA AAUUAACG	4380
1425	UUAAUUAUC AAGGACGU	225	ACGUCCUU CUGAUGAG GNNNNNNNNC CGAA AUAAUUAA	4381
1434	AAGGACGUA ACUGAAGA	226	UCUUCAGU CUGAUGAG GNNNNNNNNC CGAA ACGUCCUU	4382
1456	CAGGGAAUU AUACAAUC	227	GAUUGUAU CUGAUGAG GNNNNNNNNC CGAA AUUCCCUG	4383
1457	AGGGAAUUA UACAAUCU	228	AGAUUGUA CUGAUGAG GNNNNNNNNC CGAA AAUUCCCU	4384
1459	GGAAUUAUA CAAUCUUG	229	CAAGAUUG CUGAUGAG GNNNNNNNNC CGAA AUAAUUCC	4385
1464	UAUACAAUC UUGCUGAG	230	CUCAGCAA CUGAUGAG GNNNNNNNNC CGAA AUUGUAUA	4386
1466	UACAAUCUU GCUGAGCA	231	UGCUCAGC CUGAUGAG GNNNNNNNNC CGAA AGAUUGUA	4387
1476	CUGAGCAUA AAACAGUC	232	GACUGUUU CUGAUGAG GNNNNNNNNC CGAA AUGCUCAG	4388
1484	AAAACAGUC AAAUGUGU	233	ACACAUUU CUGAUGAG GNNNNNNNNC CGAA ACUGUUUU	4389
1493	AAAUGUGUU UAAAAACC	234	GGUUUUUA CUGAUGAG GNNNNNNNNC CGAA ACACAUUU	4390
1494	AAUGUGUUU AAAAACCU	235	AGGUUUUU CUGAUGAG GNNNNNNNNC CGAA AACACAUU	4391
1495	AUGUGUUUA AAAACCUC	236	GAGGUUUU CUGAUGAG GNNNNNNNNC CGAA AAACACAU	4392
1503	AAAAACCUC ACUGCCAC	237	GUGGCAGU CUGAUGAG GNNNNNNNNC CGAA AGGUUUUU	4393
1513	CUGCCACUC UAAUUGUC	238	GACAAUUA CUGAUGAG GNNNNNNNNC CGAA AGUGGCAG	4394
1515	GCCACUCUA AUUGUCAA	239	UUGACAAU CUGAUGAG GNNNNNNNNC CGAA AGAGUGGC	4395
1518	ACUCUAAUU GUCAAUGU	240	ACAUUGAC CUGAUGAG GNNNNNNNNC CGAA AUUAGAGU	4396
1521	CUAAUUGUC AAUGUGAA	241	UUCACAUU CUGAUGAG GNNNNNNNNC CGAA ACAAUUAG	4397
1539	CCCCAGAUU UACGAAAA	242	UUUUCGUA CUGAUGAG GNNNNNNNNC CGAA AUCUGGGG	4398
1540	CCCAGAUUU ACGAAAAG	243	CUUUUCGU CUGAUGAG GNNNNNNNNC CGAA AAUCUGGG	4399
1541	CCAGAUUUA CGAAAAGG	244	CCUUUUCG CUGAUGAG GNNNNNNNNC CGAA AAAUCUGG	4400
1556	GGCCGUGUC AUCGUUUC	245	GAAACGAU CUGAUGAG GNNNNNNNNC CGAA ACACGGCC	4401
1559	CGUGUCAUC GUUUCCAG	246	CUGGAAAC CUGAUGAG GNNNNNNNNC CGAA AUGACACG	4402
1562	GUCAUCGUU UCCAGACC	247	GGUCUGGA CUGAUGAG GNNNNNNNNC CGAA ACGAUGAC	4403
1563	UCAUCGUUU CCAGACCC	248	GGGUCUGG CUGAUGAG GNNNNNNNNC CGAA AACGAUGA	4404
1564	CAUCGUUUC CAGACCCG	249	CGGGUCUG CUGAUGAG GNNNNNNNNC CGAA AAACGAUG	4405
1576	ACCCGGCUC UCUACCCA	250	UGGGUAGA CUGAUGAG GNNNNNNNNC CGAA AGCCGGGU	4406
1578	CCGGCUCUC UACCCACU	251	AGUGGGUA CUGAUGAG GNNNNNNNNC CGAA AGAGCCGG	4407
1580	GGCUCUCUA CCCACUGG	252	CCAGUGGG CUGAUGAG GNNNNNNNNC CGAA AGAGAGCC	4408
1602	AGACAAAUC CUGACUUG	253	CAAGUCAG CUGAUGAG GNNNNNNNNC CGAA AUUUGUCU	4409
1609	UCCUGACUU GUACCGCA	254	UGCGGUAC CUGAUGAG GNNNNNNNNC CGAA AGUCAGGA	4410
1612	UGACUUGUA CCGCAUAU	255	AUAUGCGG CUGAUGAG GNNNNNNNNC CGAA ACAAGUCA	4411
1619	UACCGCAUA UGGUAUCC	256	GGAUACCA CUGAUGAG GNNNNNNNNC CGAA AUGCGGUA	4412
1624	CAUAUGGUA UCCCUCAA	257	UUGAGGGA CUGAUGAG GNNNNNNNNC CGAA ACCAUAUG	4413
1626	UAUGGUAUC CCUCAACC	258	GGUUGAGG CUGAUGAG GNNNNNNNNC CGAA AUACCAUA	4414
1630	GUAUCCCUC AACCUACA	259	UGUAGGUU CUGAUGAG GNNNNNNNNC CGAA AGGGAUAC	4415
1636	CUCAACCUA CAAUCAAG	260	CUUGAUUG CUGAUGAG GNNNNNNNNC CGAA AGGUUGAG	4416
1641	CCUACAAUC AAGUGGUU	261	AACCACUU CUGAUGAG GNNNNNNNNC CGAA AUUGUAGG	4417
1649	CAAGUGGUU CUGGCACC	262	GGUGCCAG CUGAUGAG GNNNNNNNNC CGAA ACCACUUG	4418
1650	AAGUGGUUC UGGCACCC	263	GGGUGCCA CUGAUGAG GNNNNNNNNC CGAA AACCACUU	4419
1663	ACCCCUGUA ACCAUAAU	264	AUUAUGGU CUGAUGAG GNNNNNNNNC CGAA ACAGGGGU	4420
1669	GUAACCAUA AUCAUUCC	265	GGAAUGAU CUGAUGAG GNNNNNNNNC CGAA AUGGUUAC	4421
1672	ACCAUAAUC AUUCCGAA	266	UUCGGAAU CUGAUGAG GNNNNNNNNC CGAA AUUAUGGU	4422
1675	AUAAUCAUU CCGAAGCA	267	UGCUUCGG CUGAUGAG GNNNNNNNNC CGAA AUGAUUAU	4423
1676	UAAUCAUUC CGAAGCAA	268	UUGCUUCG CUGAUGAG GNNNNNNNNC CGAA AAUGAUUA	4424
1694	GUGUGACUU UUGUUCCA	269	UGGAACAA CUGAUGAG GNNNNNNNNC CGAA AGUCACAC	4425
1695	UGUGACUUU UGUUCCAA	270	UUGGAACA CUGAUGAG GNNNNNNNNC CGAA AAGUCACA	4426
1696	GUGACUUUU GUUCCAAU	271	AUUGGAAC CUGAUGAG GNNNNNNNNC CGAA AAAGUCAC	4427
1699	ACUUUUGUU CCAAUAAU	272	AUUAUUGG CUGAUGAG GNNNNNNNNC CGAA ACAAAAGU	4428
1700	CUUUUGUUC CAAUAAUG	273	CAUUAUUG CUGAUGAG GNNNNNNNNC CGAA AACAAAAG	4429
1705	GUUCCAAUA AUGAAGAG	274	CUCUUCAU CUGAUGAG GNNNNNNNNC CGAA AUUGGAAC	4430
1715	UGAAGAGUC CUUUAUCC	275	GGAUAAAG CUGAUGAG GNNNNNNNNC CGAA ACUCUUCA	4431
1718	AGAGUCCUU UAUCCUGG	276	CCAGGAUA CUGAUGAG GNNNNNNNNC CGAA AGGACUCU	4432
1719	GAGUCCUUU AUCCUGGA	277	UCCAGGAU CUGAUGAG GNNNNNNNNC CGAA AAGGACUC	4433
1720	AGUCCUUUA UCCUGGAU	278	AUCCAGGA CUGAUGAG GNNNNNNNNC CGAA AAAGGACU	4434
1722	UCCUUUAUC CUGGAUGC	279	GCAUCCAG CUGAUGAG GNNNNNNNNC CGAA AUAAAGGA	4435
1755	AACAGAAUU GAGAGCAU	280	AUGCUCUC CUGAUGAG GNNNNNNNNC CGAA AUUCUGUU	4436
1764	GAGAGCAUC ACUCAGCG	281	CGCUGAGU CUGAUGAG GNNNNNNNNC CGAA AUGCUCUC	4437
1768	GCAUCACUC AGCGCAUG	282	CAUGCGCU CUGAUGAG GNNNNNNNNC CGAA AGUGAUGC	4438
1782	AUGGCAAUA AUAGAAGG	283	CCUUCUAU CUGAUGAG GNNNNNNNNC CGAA AUUGCCAU	4439
1785	GCAAUAAUA GAAGGAAA	284	UUUCCUUC CUGAUGAG GNNNNNNNNC CGAA AUUAUUGC	4440
1798	GAAAGAAUA AGAUGGCU	285	AGCCAUCU CUGAUGAG GNNNNNNNNC CGAA AUUCUUUC	4441
1807	AGAUGGCUA GCACCUUG	286	CAAGGUGC CUGAUGAG GNNNNNNNNC CGAA AGCCAUCU	4442
1814	AUGCACCUU GGUUGUGG	287	CCACAACC CUGAUGAG GNNNNNNNNC CGAA AGGUGCUA	4443
1818	ACCUUGGUU GUGGCUGA	288	UCAGCCAC CUGAUGAG GNNNNNNNNC CGAA ACCAAGGU	4444
1829	GGCUGACUC UAGAAUUU	289	AAAUUCUA CUGAUGAG GNNNNNNNNC CGAA AGUCAGCC	4445
1831	CUGACUCUA GAAUUUCU	290	AGAAAUUC CUGAUGAG GNNNNNNNNC CGAA AGAGUCAG	4446
1836	UCUAGAAUU UCUGGAAU	291	AUUCCAGA CUGAUGAG GNNNNNNNNC CGAA AUUCUAGA	4447
1837	CUAGAAUUU CUGGAAUC	292	GAUUCCAG CUGAUGAG GNNNNNNNNC CGAA AAUUCUAG	4448
1838	UAGAAUUUC UGGAAUCU	293	AGAUUCCA CUGAUGAG GNNNNNNNNC CGAA AAAUUCUA	4449
1845	UCUGGAAUC UACAUUUG	294	CAAAUGUA CUGAUGAG GNNNNNNNNC CGAA AUUCCAGA	4450
1847	UGGAAUCUA CAUUUGCA	295	UGCAAAUG CUGAUGAG GNNNNNNNNC CGAA AGAUUCCA	4451
1851	AUCUACAUU UGCAUAGC	296	GCUAUGCA CUGAUGAG GNNNNNNNNC CGAA AUGUAGAU	4452
1852	UCUACAUUU GCAUAGCU	297	AGCUAUGC CUGAUGAG GNNNNNNNNC CGAA AAUGUAGA	4453
1857	AUUUGCAUA GCUUCCAA	298	UUGGAAGC CUGAUGAG GNNNNNNNNC CGAA AUGCAAAU	4454
1861	GCAUAGCUU CCAAUAAA	299	UUUAUUGG CUGAUGAG GNNNNNNNNC CGAA AGCUAUGC	4455
1862	CAUAGCUUC CAAUAAAG	300	CUUUAUUG CUGAUGAG GNNNNNNNNC CGAA AAGCUAUG	4456
1867	CUUCCAAUA AAGUUGGG	301	CCCAACUU CUGAUGAG GNNNNNNNNC CGAA AUUGGAAG	4457
1872	AAUAAAGUU GGGACUGU	302	ACAGUCCC CUGAUGAG GNNNNNNNNC CGAA ACUUUAUU	4458
1893	AGAAACAUA AGCUUUUA	303	UAAAAGCU CUGAUGAG GNNNNNNNNC CGAA AUGUUUCU	4459
1898	CAUAAGCUU UUAUAUCA	304	UGAUAUAA CUGAUGAG GNNNNNNNNC CGAA AGCUUAUG	4460
1899	AUAAGCUUU UAUAUCAC	305	GUGAUAUA CUGAUGAG GNNNNNNNNC CGAA AAGCUUAU	4461
1900	UAAGCUUUU AUAUCACA	306	UGUGAUAU CUGAUGAG GNNNNNNNNC CGAA AAAGCUUA	4462
1901	AAGCUUUUA UAUCACAG	307	CUGUGAUA CUGAUGAG GNNNNNNNNC CGAA AAAAGCUU	4463
1903	GCUUUUAUA UCACAGAU	308	AUCUGUGA CUGAUGAG GNNNNNNNNC CGAA AUAAAAGC	4464
1905	UUUUAUAUC ACAGAUGU	309	ACAUCUGU CUGAUGAG GNNNNNNNNC CGAA AUAUAAAA	4465
1925	AAAUGGGUU UCAUGUUA	310	UAACAUGA CUGAUGAG GNNNNNNNNC CGAA ACCCAUUU	4466
1926	AAUGGGUUU CAUGUUAA	311	UUAACAUG CUGAUGAG GNNNNNNNNC CGAA AACCCAUU	4467
1927	AUGGGUUUC AUGUUAAC	312	GUUAACAU CUGAUGAG GNNNNNNNNC CGAA AAACCCAU	4468
1932	UUUCAUGUU AACUUGGA	313	UCCAAGUU CUGAUGAG GNNNNNNNNC CGAA ACAUGAAA	4469
1933	UUCAUGUUA ACUUGGAA	314	UUCCAAGU CUGAUGAG GNNNNNNNNC CGAA AACAUGAA	4470
1937	UGUUAACUU GGAAAAAA	315	UUUUUUCC CUGAUGAG GNNNNNNNNC CGAA AGUUAACA	4471
1976	GAAACUGUC UUGCACAG	316	CUGUGCAA CUGAUGAG GNNNNNNNNC CGAA ACAGUUUC	4472
1978	AACUGUCUU GCACAGUU	317	AACUGUGC CUGAUGAG GNNNNNNNNC CGAA AGACAGUU	4473
1986	UGCACAGUU AACAAGUU	318	AACUUGUU CUGAUGAG GNNNNNNNNC CGAA ACUGUGCA	4474
1987	GCACAGUUA ACAAGUUC	319	GAACUUGU CUGAUGAG GNNNNNNNNC CGAA AACUGUGC	4475
1994	UAACAAGUU CUUAUACA	320	UGUAUAAG CUGAUGAG GNNNNNNNNC CGAA ACUUGUUA	4476
1995	AACAAGUUC UUAUACAG	321	CUGUAUAA CUGAUGAG GNNNNNNNNC CGAA AACUUGUU	4477
1997	CAAGUUCUU AUACAGAG	322	CUCUGUAU CUGAUGAG GNNNNNNNNC CGAA AGAACUUG	4478
1998	AAGUUCUUA UACAGAGA	323	UCUCUGUA CUGAUGAG GNNNNNNNNC CGAA AAGAACUU	4479
2000	GUUCUUAUA CAGAGACG	324	CGUCUCUG CUGAUGAG GNNNNNNNNC CGAA AUAAGAAC	4480
2010	AGAGACGUU ACUUGGAU	325	AUCCAAGU CUGAUGAG GNNNNNNNNC CGAA ACGUCUCU	4481
2011	GAGACGUUA CUUGGAUU	326	AAUCCAAG CUGAUGAG GNNNNNNNNC CGAA AACGUCUC	4482
2014	ACGUUACUU GGAUUUUA	327	UAAAAUCC CUGAUGAG GNNNNNNNNC CGAA AGUAACGU	4483
2019	ACUUGGAUU UUACUGCG	328	CGCAGUAA CUGAUGAG GNNNNNNNNC CGAA AUCCAAGU	4484
2020	CUUGGAUUU UACUGCGG	329	CCGCAGUA CUGAUGAG GNNNNNNNNC CGAA AAUCCAAG	4485
2021	UUGGAUUUU ACUGCGGA	330	UCCGCAGU CUGAUGAG GNNNNNNNNC CGAA AAAUCCAA	4486
2022	UGGAUUUUA CUGCGGAC	331	GUCCGCAG CUGAUGAG GNNNNNNNNC CGAA AAAAUCCA	4487
2034	CGGACAGUU AAUAACAG	332	CUGUUAUU CUGAUGAG GNNNNNNNNC CGAA ACUGUCCG	4488
2035	GGACAGUUA AUAACAGA	333	UCUGUUAU CUGAUGAG GNNNNNNNNC CGAA AACUGUCC	4489
2038	CAGUUAAUA ACAGAACA	334	UGUUCUGU CUGAUGAG GNNNNNNNNC CGAA AUUAACUG	4490
2054	AAUGCACUA CAGUAUUA	335	UAAUACUG CUGAUGAG GNNNNNNNNC CGAA AGUGCAUU	4491
2059	ACUACAGUA UUAGCAAG	336	CUUGCUAA CUGAUGAG GNNNNNNNNC CGAA ACUGUAGU	4492
2061	UACAGUAUU AGCAAGCA	337	UGCUUGCU CUGAUGAG GNNNNNNNNC CGAA AUACUGUA	4493
2062	ACAGUAUUA GCAAGCAA	338	UUGCUUGC CUGAUGAG GNNNNNNNNC CGAA AAUACUGU	4494
2082	AUGGCCAUC ACUAAGGA	339	UCCUUAGU CUGAUGAG GNNNNNNNNC CGAA AUGGCCAU	4495
2086	CCAUCACUA AGGAGCAC	340	GUGCUCCU CUGAUGAG GNNNNNNNNC CGAA AGUGAUGG	4496
2096	GGAGCACUC CAUCACUC	341	GAGUGAUG CUGAUGAG GNNNNNNNNC CGAA AGUGCUCC	4497
2100	CACUCCAUC ACUCUUAA	342	UUAAGAGU CUGAUGAG GNNNNNNNNC CGAA AUGGAGUG	4498
2104	CCAUCACUC UUAAUCUU	343	AAGAUUAA CUGAUGAG GNNNNNNNNC CGAA AGUGAUGG	4499
2106	AUCACUCUU AAUCUUAC	344	GUAAGAUU CUGAUGAG GNNNNNNNNC CGAA AGAGUGAU	4500
2107	UCACUCUUA AUCUUACC	345	GGUAAGAU CUGAUGAG GNNNNNNNNC CGAA AAGAGUGA	4501
2110	CUCUUAAUC UUACCAUC	346	GAUGGUAA CUGAUGAG GNNNNNNNNC CGAA AUUAAGAG	4502
2112	CUUAAUCUU ACCAUCAU	347	AUGAUGGU CUGAUGAG GNNNNNNNNC CGAA AGAUUAAG	4503
2113	UUAAUCUUA CCAUCAUG	348	CAUGAUGG CUGAUGAG GNNNNNNNNC CGAA AAGAUUAA	4504
2118	CUUACCAUC AUGAAUGU	349	ACAUUCAU CUGAUGAG GNNNNNNNNC CGAA AUGGUAAG	4505
2127	AUGAAUGUU UCCCUGCA	350	UGCAGGGA CUGAUGAG GNNNNNNNNC CGAA ACAUUCAU	4506
2128	UGAAUGUUU CCCUGCAA	351	UUGCAGGG CUGAUGAG GNNNNNNNNC CGAA AACAUUCA	4507
2129	GAAUGUUUC CCUGCAAG	352	CUUGCAGG CUGAUGAG GNNNNNNNNC CGAA AAACAUUC	4508
2140	UGCAAGAUU CAGGCACC	353	GGUGCCUG CUGAUGAG GNNNNNNNNC CGAA AUCUUGCA	4509
2141	GCAAGAUUC AGGCACCU	354	AGGUGCCU CUGAUGAG GNNNNNNNNC CGAA AAUCUUGC	4510
2150	AGGCACCUA UGCCUGCA	355	UGCAGGCA CUGAUGAG GNNNNNNNNC CGAA AGGUGCCU	4511
2172	AGGAAUGUA UACACAGG	356	CCUGUGUA CUGAUGAG GNNNNNNNNC CGAA ACAUUCCU	4512
2174	GAAUGUAUA CACAGGGG	357	CCCCUGUG CUGAUGAG GNNNNNNNNC CGAA AUACAUUC	4513
2190	GAAGAAAUC CUCCAGAA	358	UUCUGGAG CUGAUGAG GNNNNNNNNC CGAA AUUUCUUC	4514
2193	GAAAUCCUC CAGAAGAA	359	UUCUUCUG CUGAUGAG GNNNNNNNNC CGAA AGGAUUUC	4515
2208	AAAGAAAUU ACAAUCAG	360	CUGAUUGU CUGAUGAG GNNNNNNNNC CGAA AUUUCUUU	4516
2209	AAGAAAUUA CAAUCAGA	361	UCUGAUUG CUGAUGAG GNNNNNNNNC CGAA AAUUUCUU	4517
2214	AUUACAAUC AGAGAUCA	362	UGAUCUCU CUGAUGAG GNNNNNNNNC CGAA AUUGUAAU	4518
2221	UCAGAGAUC AGGAAGCA	363	UGCUUCCU CUGAUGAG GNNNNNNNNC CGAA AUCUCUGA	4519
2234	AGCACCAUA CCUCCUGC	364	GCAGGAGG CUGAUGAG GNNNNNNNNC CGAA AUGGUGCU	4520
2238	CCAUACCUC CUGCGAAA	365	UUUCGCAG CUGAUGAG GNNNNNNNNC CGAA AGGUAUGG	4521
2250	CGAAACCUC AGUGAUCA	366	UGAUCACU CUGAUGAG GNNNNNNNNC CGAA AGGUUUCG	4522
2257	UCAGUGAUC ACACAGUG	367	CACUGUGU CUGAUGAG GNNNNNNNNC CGAA AUCACUGA	4523
2271	GUGGCCAUC AGCAGUUC	368	GAACUGCU CUGAUGAG GNNNNNNNNC CGAA AUGGCCAC	4524
2278	UCAGCAGUU CCACCACU	369	AGUGGUGG CUGAUGAG GNNNNNNNNC CGAA ACUGCUGA	4525
2279	CAGCAGUUC CACCACUU	370	AAGUGGUG CUGAUGAG GNNNNNNNNC CGAA AACUGCUG	4526
2287	CCACCACUU UAGACUGU	371	ACAGUCUA CUGAUGAG GNNNNNNNNC CGAA AGUGGUGG	4527
2288	CACCACUUU AGACUGUC	372	GACAGUCU CUGAUGAG GNNNNNNNNC CGAA AAGUGGUG	4528
2289	ACCACUUUA GACUGUCA	373	UGACAGUC CUGAUGAG GNNNNNNNNC CGAA AAAGUGGU	4529
2296	UAGACUGUC AUGCUAAU	374	AUUAGCAU CUGAUGAG GNNNNNNNNC CGAA ACAGUCUA	4530
2302	GUCAUGCUA AUGGUGUC	375	GACACCAU CUGAUGAG GNNNNNNNNC CGAA AGCAUGAC	4531
2310	AAUGGUGUC CCCGAGCC	376	GGCUCGGG CUGAUGAG GNNNNNNNNC CGAA ACACCAUU	4532
2320	CCGAGCCUC AGAUCACU	377	AGUGAUCU CUGAUGAG GNNNNNNNNC CGAA AGGCUCGG	4533
2325	CCUCAGAUC ACUUGGUU	378	AACCAAGU CUGAUGAG GNNNNNNNNC CGAA AUCUGAGG	4534
2329	AGAUCACUU GGUUUAAA	379	UUUAAACC CUGAUGAG GNNNNNNNNC CGAA AGUGAUCU	4535
2333	CACUUGGUU UAAAAACA	380	UGUUUUUA CUGAUGAG GNNNNNNNNC CGAA ACCAAGUG	4536
2334	ACUUGGUUU AAAAACAA	381	UUGUUUUU CUGAUGAG GNNNNNNNNC CGAA AACCAAGU	4537
2335	CUUGGUUUA AAAACAAC	382	GUUGUUUU CUGAUGAG GNNNNNNNNC CGAA AAACCAAG	4538
2352	CACAAAAUA CAACAAGA	383	UCUUGUUG CUGAUGAG GNNNNNNNNC CGAA AUUUUGUG	4539
2370	CCUGGAAUU AUUUUAGG	384	CCUAAAAU CUGAUGAG GNNNNNNNNC CGAA AUUCCAGG	4540
2371	CUGGAAUUA UUUUAGGA	385	UCCUAAAA CUGAUGAG GNNNNNNNNC CGAA AAUUCCAG	4541
2373	GGAAUUAUU UUAGGACC	386	GGUCCUAA CUGAUGAG GNNNNNNNNC CGAA AUAAUUCC	4542
2374	GAAUUAUUU UAGGACCA	387	UGGUCCUA CUGAUGAG GNNNNNNNNC CGAA AAUAAUUC	4543
2375	AAUUAUUUU AGGACCAG	388	CUGGUCCU CUGAUGAG GNNNNNNNNC CGAA AAAUAAUU	4544
2376	AUUAUUUUA GGACCAGG	389	CCUGGUCC CUGAUGAG GNNNNNNNNC CGAA AAAAUAAU	4545
2399	CACGCUGUU UAUUGAAA	390	UUUCAAUA CUGAUGAG GNNNNNNNNC CGAA ACAGCGUG	4546
2400	ACGCUGUUU AUUGAAAG	391	CUUUCAAU CUGAUGAG GNNNNNNNNC CGAA AACAGCGU	4547
2401	CGCUGUUUA UUGAAAGA	392	UCUUUCAA CUGAUGAG GNNNNNNNNC CGAA AAACAGCG	4548
2403	CUGUUUAUU GAAAGAGU	393	ACUCUUUC CUGAUGAG GNNNNNNNNC CGAA AUAAACAG	4549
2412	GAAAGAGUC ACAGAAGA	394	UCUUCUGU CUGAUGAG GNNNNNNNNC CGAA ACUCUUUC	4550
2433	GAAGGUGUC UAUCACUG	395	CAGUGAUA CUGAUGAG GNNNNNNNNC CGAA ACACCUUC	4551
2435	AGGUGUCUA UCACUGCA	396	UGCAGUGA CUGAUGAG GNNNNNNNNC CGAA AGACACCU	4552
2437	GUGUCUAUC ACUGCAAA	397	UUUGCAGU CUGAUGAG GNNNNNNNNC CGAA AUAGACAC	4553
2465	GAAGGGCUC UGUGGAAA	398	UUUCCACA CUGAUGAG GNNNNNNNNC CGAA AGCCCUUC	4554
2476	UGGAAAGUU CAGCAUAC	399	GUAUGCUG CUGAUGAG GNNNNNNNNC CGAA ACUUUCCA	4555
2477	GGAAAGUUC AGCAUACC	400	GGUAUGCU CUGAUGAG GNNNNNNNNC CGAA AACUUUCC	4556
2483	UUCAGCAUA CCUCACUG	401	CAGUGAGG CUGAUGAG GNNNNNNNNC CGAA AUGCUGAA	4557
2487	GCAUACCUC ACUGUUCA	402	UGAACAGU CUGAUGAG GNNNNNNNNC CGAA AGGUAUGC	4558
2493	CUCACUGUU CAAGGAAC	403	GUUCCUUG CUGAUGAG GNNNNNNNNC CGAA ACAGUGAG	4559
2494	UCACUGUUC AAGGAACC	404	GGUUCCUU CUGAUGAG GNNNNNNNNC CGAA AACAGUGA	4560
2504	AGGAACCUC GGACAAGU	405	ACUUGUCC CUGAUGAG GNNNNNNNNC CGAA AGGUUCCU	4561
2513	GGACAAGUC UAAUCUGG	406	CCAGAUUA CUGAUGAG GNNNNNNNNC CGAA ACUUGUCC	4562
2515	ACAAGUCUA AUCUGGAG	407	CUCCAGAU CUGAUGAG GNNNNNNNNC CGAA AGACUUGU	4563
2518	AGUCUAAUC UGGAGCUG	408	CAGCUCCA CUGAUGAG GNNNNNNNNC CGAA AUUAGACU	4564
2529	GAGCUGAUC ACUCUAAC	409	GUUAGAGU CUGAUGAG GNNNNNNNNC CGAA AUCAGCUC	4565
2533	UGAUCACUC UAACAUGC	410	GCAUGUUA CUGAUGAG GNNNNNNNNC CGAA AGUGAUCA	4566
2535	AUCACUCUA ACAUGCAC	411	GUGCAUGU CUGAUGAG GNNNNNNNNC CGAA AGAGUGAU	4567
2560	CUGCGACUC UCUUCUGG	412	CCAGAAGA CUGAUGAG GNNNNNNNNC CGAA AGUCGCAG	4568
2562	GCGACUCUC UUCUGGCU	413	AGCCAGAA CUGAUGAG GNNNNNNNNC CGAA AGAGUCGC	4569
2564	GACUCUCUU CUGGCUCC	414	GGAGCCAG CUGAUGAG GNNNNNNNNC CGAA AGAGAGUC	4570
2565	ACUCUCUUC UGGCUCCU	415	AGGAGCCA CUGAUGAG GNNNNNNNNC CGAA AAGAGAGU	4571
2571	UUCUGGCUC CUAUUAAC	416	GUUAAUAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGAA	4572
2574	UGGCUCCUA UUAACCCU	417	AGGGUUAA CUGAUGAG GNNNNNNNNC CGAA AGGAGCCA	4573
2576	GCUCCUAUU AACCCUCC	418	GGAGGGUU CUGAUGAG GNNNNNNNNC CGAA AUAGGAGC	4574
2577	CUCCUAUUA ACCCUCCU	419	AGGAGGGU CUGAUGAG GNNNNNNNNC CGAA AAUAGGAG	4575
2583	UUAACCCUC CUUAUCCG	420	CGGAUAAG CUGAUGAG GNNNNNNNNC CGAA AGGGUUAA	4576
2586	ACCCUCCUU AUCCGAAA	421	UUUCGGAU CUGAUGAG GNNNNNNNNC CGAA AGGAGGGU	4577
2587	CCCUCCUUA UCCGAAAA	422	UUUUCGGA CUGAUGAG GNNNNNNNNC CGAA AAGGAGGG	4578
2589	CUCCUUAUC CGAAAAAU	423	AUUUUUCG CUGAUGAG GNNNNNNNNC CGAA AUAAGGAG	4579
2606	GAAAAGGUC UUCUUCUG	424	CAGAAGAA CUGAUGAG GNNNNNNNNC CGAA ACCUUUUC	4580
2608	AAAGGUCUU CUUCUGAA	425	UUCAGAAG CUGAUGAG GNNNNNNNNC CGAA AGACCUUU	4581
2609	AAGGUCUUC UUCUGAAA	426	UUUCAGAA CUGAUGAG GNNNNNNNNC CGAA AAGACCUU	4582
2611	GGUCUUCUU CUGAAAUA	427	UAUUUCAG CUGAUGAG GNNNNNNNNC CGAA AGAAGACC	4583
2612	GUCUUCUUC UGAAAUAA	428	UUAUUUCA CUGAUGAG GNNNNNNNNC CGAA AAGAAGAC	4584
2619	UCUGAAAUA AAGACUGA	429	UCAGUCUU CUGAUGAG GNNNNNNNNC CGAA AUUUCAGA	4585
2630	GACUGACUA CCUAUCAA	430	UUGAUAGG CUGAUGAG GNNNNNNNNC CGAA AGUCAGUC	4586
2634	GACUACCUA UCAAUUAU	431	AUAAUUGA CUGAUGAG GNNNNNNNNC CGAA AGGUAGUC	4587
2636	CUACCUAUC AAUUAUAA	432	UUAUAAUU CUGAUGAG GNNNNNNNNC CGAA AUAGGUAG	4588
2640	CUAUCAAUU AUAAUGGA	433	UCCAUUAU CUGAUGAG GNNNNNNNNC CGAA AUUGAUAG	4589
2641	UAUCAAUUA UAAUGGAC	434	GUCCAUUA CUGAUGAG GNNNNNNNNC CGAA AAUUGAUA	4590
2643	UCAAUUAUA AUGGACCC	435	GGGUCCAU CUGAUGAG GNNNNNNNNC CGAA AUAAUUGA	4591
2661	GAUGAAGUU CCUUUGGA	436	UCCAAAGG CUGAUGAG GNNNNNNNNC CGAA ACUUCAUC	4592
2662	AUGAAGUUC CUUUGGAU	437	AUCCAAAG CUGAUGAG GNNNNNNNNC CGAA AACUUCAU	4593
2665	AAGUUCCUU UGGAUGAG	438	CUCAUCCA CUGAUGAG GNNNNNNNNC CGAA AGGAACUU	4594
2666	AGUUCCUUU GGAUGAGC	439	GCUCAUCC CUGAUGAG GNNNNNNNNC CGAA AAGGAACU	4595
2688	GAGCGGCUC CCUUAUGA	440	UCAUAAGG CUGAUGAG GNNNNNNNNC CGAA AGCCGCUC	4596
2692	GGCUCCCUU AUGAUGCC	441	GGCAUCAU CUGAUGAG GNNNNNNNNC CGAA AGGGAGCC	4597
2693	GCUCCCUUA UGAUGCCA	442	UGGCAUCA CUGAUGAG GNNNNNNNNC CGAA AAGGGAGC	4598
2714	GUGGGAGUU UGCCCGGG	443	CCCGGGCA CUGAUGAG GNNNNNNNNC CGAA ACUCCCAC	4599
2715	UGGGAGUUU GCCCGGGA	444	UCCCGGGC CUGAUGAG GNNNNNNNNC CGAA AACUCCCA	4600
2730	GAGAGACUU AAACUGGG	445	CCCAGUUU CUGAUGAG GNNNNNNNNC CGAA AGUCUCUC	4601
2731	AGAGACUUA AACUGGGC	446	GCCCAGUU CUGAUGAG GNNNNNNNNC CGAA AAGUCUCU	4602
2744	GGGCAAAUC ACUUGGAA	447	UUCCAAGU CUGAUGAG GNNNNNNNNC CGAA AUUUGCCC	4603
2748	AAAUCACUU GGAAGAGG	448	CCUCUUCC CUGAUGAG GNNNNNNNNC CGAA AGUGAUUU	4604
2761	GAGGGGCUU UUGGAAAA	449	UUUUCCAA CUGAUGAG GNNNNNNNNC CGAA AGCCCCUC	4605
2762	AGGGGCUUU UGGAAAAG	450	CUUUUCCA CUGAUGAG GNNNNNNNNC CGAA AAGCCCCU	4606
2763	GGGGCUUUU GGAAAAGU	451	ACUUUUCC CUGAUGAG GNNNNNNNNC CGAA AAAGCCCC	4607
2775	AAAGUGGUU CAAGCAUC	452	GAUGCUUG CUGAUGAG GNNNNNNNNC CGAA ACCACUUU	4608
2776	AAGUGGUUC AAGCAUCA	453	UGAUGCUU CUGAUGAG GNNNNNNNNC CGAA AACCACUU	4609
2783	UCAAGCAUC AGCAUUUG	454	CAAAUGCU CUGAUGAG GNNNNNNNNC CGAA AUGCUUGA	4610
2789	AUCAGCAUU UGGCAUUA	455	UAAUGCCA CUGAUGAG GNNNNNNNNC CGAA AUGCUGAU	4611
2790	UCAGCAUUU GGCAUUAA	456	UUAAUGCC CUGAUGAG GNNNNNNNNC CGAA AAUGCUGA	4612
2796	UUUGGCAUU AAGAAAUC	457	GAUUUCUU CUGAUGAG GNNNNNNNNC CGAA AUGCCAAA	4613
2797	UUGGCAUUA AGAAAUCA	458	UGAUUUCU CUGAUGAG GNNNNNNNNC CGAA AAUGCCAA	4614
2804	UAAGAAAUC ACCUACGU	459	ACGUAGGU CUGAUGAG GNNNNNNNNC CGAA AUUUCUUA	4615
2809	AAUCACCUA CGUGCCGG	460	CCGGCACG CUGAUGAG GNNNNNNNNC CGAA AGGUGAUU	4616
2864	CAGCGAGUA CAAAGCUC	461	GAGCUUUG CUGAUGAG GNNNNNNNNC CGAA ACUCGCUG	4617
2872	ACAAAGCUC UGAUGACU	462	AGUCAUCA CUGAUGAG GNNNNNNNNC CGAA AGCUUUGU	4618
2886	ACUGAGCUA AAAAUCUU	463	AAGAUUUU CUGAUGAG GNNNNNNNNC CGAA AGCUCAGU	4619
2892	CUAAAAAUC UUGACCCA	464	UGGGUCAA CUGAUGAG GNNNNNNNNC CGAA AUUUUUAG	4620
2894	AAAAAUCUU GACCCACA	465	UGUGGGUC CUGAUGAG GNNNNNNNNC CGAA AGAUUUUU	4621
2904	ACCCACAUU GGCCACCA	466	UGGUGGCC CUGAUGAG GNNNNNNNNC CGAA AUGUGGGU	4622
2914	GCCACCAUC UGAACGUG	467	CACGUUCA CUGAUGAG GNNNNNNNNC CGAA AUGGUGGC	4623
2925	AACGUGGUU AACCUGCU	468	AGCAGGUU CUGAUGAG GNNNNNNNNC CGAA ACCACGUU	4624
2926	ACGUGGUUA ACCUGCUG	469	CAGCAGGU CUGAUGAG GNNNNNNNNC CGAA AACCACGU	4625
2962	GAGGGCCUC UGAUGGUG	470	CACCAUCA CUGAUGAG GNNNNNNNNC CGAA AGGCCCUC	4626
2973	AUGGUGAUU GUUGAAUA	471	UAUUCAAC CUGAUGAG GNNNNNNNNC CGAA AUCACCAU	4627
2976	GUGAUUGUU GAAUACUG	472	CAGUAUUC CUGAUGAG GNNNNNNNNC CGAA ACAAUCAC	4628
2981	UGUUGAAUA CUGCAAAU	473	AUUUGCAG CUGAUGAG GNNNNNNNNC CGAA AUUCAACA	4629
2990	CUGCAAAUA UGGAAAUC	474	GAUUUCCA CUGAUGAG GNNNNNNNNC CGAA AUUUGCAG	4630
2998	AUGGAAAUC UCUCCAAC	475	GUUGGAGA CUGAUGAG GNNNNNNNNC CGAA AUUUCCAU	4631
3000	GGAAAUCUC UCCAACUA	476	UAGUUGGA CUGAUGAG GNNNNNNNNC CGAA AGAUUUCC	4632
3002	AAAUCUCUC CAACUACC	477	GGUAGUUG CUGAUGAG GNNNNNNNNC CGAA AGAGAUUU	4633
3008	CUCCAACUA CCUCAAGA	478	UCUUGAGG CUGAUGAG GNNNNNNNNC CGAA AGUUGGAG	4634
3012	AACUACCUC AAGAGCAA	479	UUGCUCUU CUGAUGAG GNNNNNNNNC CGAA AGGUAGUU	4635
3029	ACGUGACUU AUUUUUUC	480	GAAAAAAU CUGAUGAG GNNNNNNNNC CGAA AGUCACGU	4636
3030	CGUGACUUA UUUUUUCU	481	AGAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAGUCACG	4637
3032	UGACUUAUU UUUUCUCA	482	UGAGAAAA CUGAUGAG GNNNNNNNNC CGAA AUAAGUCA	4638
3033	GACUUAUUU UUUCUCAA	483	UUGAGAAA CUGAUGAG GNNNNNNNNC CGAA AAUAAGUC	4639
3034	ACUUAUUUU UUCUCAAC	484	GUUGAGAA CUGAUGAG GNNNNNNNNC CGAA AAAUAAGU	4640
3035	CUUAUUUUU UCUCAACA	485	UGUUGAGA CUGAUGAG GNNNNNNNNC CGAA AAAAUAAG	4641
3036	UUAUUUUUU CUCAACAA	486	UUGUUGAG CUGAUGAG GNNNNNNNNC CGAA AAAAAUAA	4642
3037	UAUUUUUUC UCAACAAG	487	CUUGUUGA CUGAUGAG GNNNNNNNNC CGAA AAAAAAUA	4643
3039	UUUUUUCUC AACAAGGA	488	UCCUUGUU CUGAUGAG GNNNNNNNNC CGAA AGAAAAAA	4644
3057	GCAGCACUA CACAUGGA	489	UCCAUGUG CUGAUGAG GNNNNNNNNC CGAA AGUGCUGC	4645
3070	UGGAGCCUA AGAAAGAA	490	UUCUUUCU CUGAUGAG GNNNNNNNNC CGAA AGGCUCCA	4646
3120	CCAAGACUA GAUAGCGU	491	ACGCUAUC CUGAUGAG GNNNNNNNNC CGAA AGUCUUGG	4647
3124	GACUAGAUA GCGUCACC	492	GGUGACGC CUGAUGAG GNNNNNNNNC CGAA AUCUAGUC	4648
3129	GAUAGCGUC ACCAGCAG	493	CUGCUGGU CUGAUGAG GNNNNNNNNC CGAA ACGCUAUC	4649
3146	CGAAAGCUU UGCGAGCU	494	AGCUCGCA CUGAUGAG GNNNNNNNNC CGAA AGCUUUCG	4650
3147	GAAAGCUUU GCGAGCUC	495	GAGCUCGC CUGAUGAG GNNNNNNNNC CGAA AAGCUUUC	4651
3155	UGCGAGCUC CGGCUUUC	496	GAAAGCCG CUGAUGAG GNNNNNNNNC CGAA AGCUCGCA	4652
3161	CUCCGGCUU UCAGGAAG	497	CUUCCUGA CUGAUGAG GNNNNNNNNC CGAA AGCCGGAG	4653
3162	UCCGGCUUU CAGGAAGA	498	UCUUCCUG CUGAUGAG GNNNNNNNNC CGAA AAGCCGGA	4654
3163	CCGGCUUUC AGGAAGAU	499	AUCUUCCU CUGAUGAG GNNNNNNNNC CGAA AAAGCCGG	4655
3172	AGGAAGAUA AAAGUCUG	500	CAGACUUU CUGAUGAG GNNNNNNNNC CGAA AUCUUCCU	4656
3178	AUAAAAGUC UGAGUGAU	501	AUCACUCA CUGAUGAG GNNNNNNNNC CGAA ACUUUUAU	4657
3189	AGUGAUGUU GAGGAAGA	502	UCUUCCUC CUGAUGAG GNNNNNNNNC CGAA ACAUCACU	4658
3205	AGGAGGAUU CUGACGGU	503	ACCGUCAG CUGAUGAG GNNNNNNNNC CGAA AUCCUCCU	4659
3206	GGAGGAUUC UGACGGUU	504	AACCGUCA CUGAUGAG GNNNNNNNNC CGAA AAUCCUCC	4660
3214	CUGACGGUU UCUACAAG	505	CUUGUAGA CUGAUGAG GNNNNNNNNC CGAA ACCGUCAG	4661
3215	UGACGGUUU CUACAAGG	506	CCUUGUAG CUGAUGAG GNNNNNNNNC CGAA AACCGUCA	4662
3216	GACGGUUUC UACAAGGA	507	UCCUUGUA CUGAUGAG GNNNNNNNNC CGAA AAACCGUC	4663
3218	CGGUUUCUA CAAGGAGC	508	GCUCCUUG CUGAUGAG GNNNNNNNNC CGAA AGAAACCG	4664
3231	GAGCCCAUC ACUAUGGA	509	UCCAUAGU CUGAUGAG GNNNNNNNNC CGAA AUGGGCUC	4665
3235	CCAUCACUA UGGAAGAU	510	AUCUUCCA CUGAUGAG GNNNNNNNNC CGAA AGUGAUGG	4666
3244	UGGAAGAUC UGAUUUCU	511	AGAAAUCA CUGAUGAG GNNNNNNNNC CGAA AUCUUCCA	4667
3249	GAUCUGAUU UCUUACAG	512	CUGUAAGA CUGAUGAG GNNNNNNNNC CGAA AUCAGAUC	4668
3250	AUCUGAUUU CUUACAGU	513	ACUGUAAG CUGAUGAG GNNNNNNNNC CGAA AAUCAGAU	4669
3251	UCUGAUUUC UUACAGUU	514	AACUGUAA CUGAUGAG GNNNNNNNNC CGAA AAAUCAGA	4670
3253	UGAUUUCUU ACAGUUUU	515	AAAACUGU CUGAUGAG GNNNNNNNNC CGAA AGAAAUCA	4671
3254	GAUUUCUUA CAGUUUUC	516	GAAAACUG CUGAUGAG GNNNNNNNNC CGAA AAGAAAUC	4672
3259	CUUACAGUU UUCAAGUG	517	CACUUGAA CUGAUGAG GNNNNNNNNC CGAA ACUGUAAG	4673
3260	UUACAGUUU UCAAGUGG	518	CCACUUGA CUGAUGAG GNNNNNNNNC CGAA AACUGUAA	4674
3261	UACAGUUUU CAAGUGGC	519	GCCACUUG CUGAUGAG GNNNNNNNNC CGAA AAACUGUA	4675
3262	ACAGUUUUC AAGUGGCC	520	GGCCACUU CUGAUGAG GNNNNNNNNC CGAA AAAACUGU	4676
3284	CAUGGAGUU CCUGUCUU	521	AAGACAGG CUGAUGAG GNNNNNNNNC CGAA ACUCCAUG	4677
3285	AUGGAGUUC CUGUCUUC	522	GAAGACAG CUGAUGAG GNNNNNNNNC CGAA AACUCCAU	4678
3290	GUUCCUGUC UUCCAGAA	523	UUCUGGAA CUGAUGAG GNNNNNNNNC CGAA ACAGGAAC	4679
3292	UCCUGUCUU CCAGAAAG	524	CUUUCUGG CUGAUGAG GNNNNNNNNC CGAA AGACAGGA	4680
3293	CCUGUCUUC CAGAAAGU	525	ACUUUCUG CUGAUGAG GNNNNNNNNC CGAA AAGACAGG	4681
3306	AAGUGCAUU CAUCGGGA	526	UCCCGAUG CUGAUGAG GNNNNNNNNC CGAA AUGCACUU	4682
3307	AGUGCAUUC AUCGGGAC	527	GUCCCGAU CUGAUGAG GNNNNNNNNC CGAA AAUGCACU	4683
3310	GCAUUCAUC GGGACCUG	528	CAGGUCCC CUGAUGAG GNNNNNNNNC CGAA AUGAAUGC	4684
3333	AGAAACAUU CUUUUAUC	529	GAUAAAAG CUGAUGAG GNNNNNNNNC CGAA AUGUUUCU	4685
3334	GAAACAUUC UUUUAUCU	530	AGAUAAAA CUGAUGAG GNNNNNNNNC CGAA AAUGUUUC	4686
3336	AACAUUCUU UUAUCUGA	531	UCAGAUAA CUGAUGAG GNNNNNNNNC CGAA AGAAUGUU	4687
3337	ACAUUCUUU UAUCUGAG	532	CUCAGAUA CUGAUGAG GNNNNNNNNC CGAA AAGAAUGU	4688
3338	CAUUCUUUU AUCUGAGA	533	UCUCAGAU CUGAUGAG GNNNNNNNNC CGAA AAAGAAUG	4689
3339	AUUCUUUUA UCUGAGAA	534	UUCUCAGA CUGAUGAG GNNNNNNNNC CGAA AAAAGAAU	4690
3341	UCUUUUAUC UGAGAACA	535	UGUUCUCA CUGAUGAG GNNNNNNNNC CGAA AUAAAAGA	4691
3363	GUGAAGAUU UGUGAUUU	536	AAAUCACA CUGAUGAG GNNNNNNNNC CGAA AUCUUCAC	4692
3364	UGAAGAUUU GUGAUUUU	537	AAAAUCAC CUGAUGAG GNNNNNNNNC CGAA AAUCUUCA	4693
3370	UUUGUGAUU UUGGCCUU	538	AAGGCCAA CUGAUGAG GNNNNNNNNC CGAA AUCACAAA	4694
3371	UUGUGAUUU UGGCCUUG	539	CAAGGCCA CUGAUGAG GNNNNNNNNC CGAA AAUCACAA	4695
3372	UGUGAUUUU GGCCUUGC	540	GCAAGGCC CUGAUGAG GNNNNNNNNC CGAA AAAUCACA	4696
3378	UUUGGCCUU GCCCGGGA	541	UCCCGGGC CUGAUGAG GNNNNNNNNC CGAA AGGCCAAA	4697
3388	CCCGGGAUA UUUAUAAG	542	CUUAUAAA CUGAUGAG GNNNNNNNNC CGAA AUCCCGGG	4698
3390	CGGGAUAUU UAUAAGAA	543	UUCUUAUA CUGAUGAG GNNNNNNNNC CGAA AUAUCCCG	4699
3391	GGGAUAUUU AUAAGAAC	544	GUUCUUAU CUGAUGAG GNNNNNNNNC CGAA AAUAUCCC	4700
3392	GGAUAUUUA UAAGAACC	545	GGUUCUUA CUGAUGAG GNNNNNNNNC CGAA AAAUAUCC	4701
3394	AUAUUUAUA AGAACCCC	546	GGGGUUCU CUGAUGAG GNNNNNNNNC CGAA AUAAAUAU	4702
3406	ACCCCGAUU AUGUGAGA	547	UCUCACAU CUGAUGAG GNNNNNNNNC CGAA AUCGGGGU	4703
3407	CCCCGAUUA UGUGAGAA	548	UUCUCACA CUGAUGAG GNNNNNNNNC CGAA AAUCGGGG	4704
3424	AAGGAGAUA CUCGACUU	549	AAGUCGAG CUGAUGAG GNNNNNNNNC CGAA AUCUCCUU	4705
3427	GAGAUACUC GACUUCCU	550	AGGAAGUC CUGAUGAG GNNNNNNNNC CGAA AGUAUCUC	4706
3432	ACUCGACUU CCUCUGAA	551	UUCAGAGG CUGAUGAG GNNNNNNNNC CGAA AGUCGAGU	4707
3433	CUCGACUUC CUCUGAAA	552	UUUCAGAG CUGAUGAG GNNNNNNNNC CGAA AAGUCGAG	4708
3436	GACUUCCUC UGAAAUGG	553	CCAUUUCA CUGAUGAG GNNNNNNNNC CGAA AGGAAGUC	4709
3451	GGAUGGCUC CCGAAUCU	554	AGAUUCGG CUGAUGAG GNNNNNNNNC CGAA AGCCAUCC	4710
3458	UCCCGAAUC UAUCUUUG	555	CAAAGAUA CUGAUGAG GNNNNNNNNC CGAA AUUCGGGA	4711
3460	CCGAAUCUA UCUUUGAC	556	GUCAAAGA CUGAUGAG GNNNNNNNNC CGAA AGAUUCGG	4712
3462	GAAUCUAUC UUUGACAA	557	UUGUCAAA CUGAUGAG GNNNNNNNNC CGAA AUAGAUUC	4713
3464	AUCUAUCUU UGACAAAA	558	UUUUGUCA CUGAUGAG GNNNNNNNNC CGAA AGAUAGAU	4714
3465	UCUAUCUUU GACAAAAU	559	AUUUUGUC CUGAUGAG GNNNNNNNNC CGAA AAGAUAGA	4715
3474	GACAAAAUC UACAGCAC	560	GUGCUGUA CUGAUGAG GNNNNNNNNC CGAA AUUUUGUC	4716
3476	CAAAAUCUA CAGCACCA	561	UGGUGCUG CUGAUGAG GNNNNNNNNC CGAA AGAUUUUG	4717
3500	CGUGUGGUC UUACGGAG	562	CUCCGUAA CUGAUGAG GNNNNNNNNC CGAA ACCACACG	4718
3502	UGUGGUCUU ACGGAGUA	563	UACUCCGU CUGAUGAG GNNNNNNNNC CGAA AGACCACA	4719
3503	GUGGUCUUA CGGAGUAU	564	AUACUCCG CUGAUGAG GNNNNNNNNC CGAA AAGACCAC	4720
3510	UACGGAGUA UUGCUGUG	565	CACAGCAA CUGAUGAG GNNNNNNNNC CGAA ACUCCGUA	4721
3512	CGGAGUAUU GCUGUGGG	566	CCCACAGC CUGAUGAG GNNNNNNNNC CGAA AUACUCCG	4722
3525	UGGGAAAUC UUCUCCUU	567	AAGGAGAA CUGAUGAG GNNNNNNNNC CGAA AUUUCCCA	4723
3527	GGAAAUCUU CUCCUUAG	568	CUAAGGAG CUGAUGAG GNNNNNNNNC CGAA AGAUUUCC	4724
3528	GAAAUCUUC UCCUUAGG	569	CCUAAGGA CUGAUGAG GNNNNNNNNC CGAA AAGAUUUC	4725
3530	AAUCUUCUC CUUAGGUG	570	CACCUAAG CUGAUGAG GNNNNNNNNC CGAA AGAAGAUU	4726
3533	CUUCUCCUU AGGUGGGU	571	ACCCACCU CUGAUGAG GNNNNNNNNC CGAA AGGAGAAG	4727
3534	UUCUCCUUA GGUGGGUC	572	GACCCACC CUGAUGAG GNNNNNNNNC CGAA AAGGAGAA	4728
3542	AGGUGGGUC UCCAUACC	573	GGUAUGGA CUGAUGAG GNNNNNNNNC CGAA ACCCACCU	4729
3544	GUGGGUCUC CAUACCCA	574	UGGGUAUG CUGAUGAG GNNNNNNNNC CGAA AGACCCAC	4730
3548	GUCUCCAUA CCCAGGAG	575	CUCCUGGG CUGAUGAG GNNNNNNNNC CGAA AUGGAGAC	4731
3558	CCAGGAGUA CAAAUGGA	576	UCCAUUUG CUGAUGAG GNNNNNNNNC CGAA ACUCCUGG	4732
3575	UGAGGACUU UUGCAGUC	577	GACUGCAA CUGAUGAG GNNNNNNNNC CGAA AGUCCUCA	4733
3576	GAGGACUUU UGCAGUCG	578	CGACUGCA CUGAUGAG GNNNNNNNNC CGAA AAGUCCUC	4734
3577	AGGACUUUU GCAGUCGC	579	GCGACUGC CUGAUGAG GNNNNNNNNC CGAA AAAGUCCU	4735
3583	UUUGCAGUC GCCUGAGG	580	CCUCAGGC CUGAUGAG GNNNNNNNNC CGAA ACUGCAAA	4736
3613	UGAGAGCUC CUGAGUAC	581	GUACUCAG CUGAUGAG GNNNNNNNNC CGAA AGCUCUCA	4737
3620	UCCUGAGUA CUCUACUC	582	GAGUAGAG CUGAUGAG GNNNNNNNNC CGAA ACUCAGGA	4738
3623	UGAGUACUC UACUCCUG	583	CAGGAGUA CUGAUGAG GNNNNNNNNC CGAA AGUACUCA	4739
3625	AGUACUCUA CUCCUGAA	584	UUCAGGAG CUGAUGAG GNNNNNNNNC CGAA AGAGUACU	4740
3628	ACUCUACUC CUGAAAUC	585	GAUUUCAG CUGAUGAG GNNNNNNNNC CGAA AGUAGAGU	4741
3636	CCUGAAAUC UAUCAGAU	586	AUCUGAUA CUGAUGAG GNNNNNNNNC CGAA AUUUCAGG	4742
3638	UGAAAUCUA UCAGAUCA	587	UGAUCUGA CUGAUGAG GNNNNNNNNC CGAA AGAUUUCA	4743
3640	AAAUCUAUC AGAUCAUG	588	CAUGAUCU CUGAUGAG GNNNNNNNNC CGAA AUAGAUUU	4744
3645	UAUCAGAUC AUGCUGGA	589	UCCAGCAU CUGAUGAG GNNNNNNNNC CGAA AUCUGAUA	4745
3689	GCCAAGAUU UGCAGAAC	590	GUUCUGCA CUGAUGAG GNNNNNNNNC CGAA AUCUUGGC	4746
3690	CCAAGAUUU GCAGAACU	591	AGUUCUGC CUGAUGAG GNNNNNNNNC CGAA AAUCUUGG	4747
3699	GCAGAACUU GUGGAAAA	592	UUUUCCAC CUGAUGAG GNNNNNNNNC CGAA AGUUCUGC	4748
3711	GAAAAACUA GGUGAUUU	593	AAAUCACC CUGAUGAG GNNNNNNNNC CGAA AGUUUUUC	4749
3718	UAGGUGAUU UGCUUCAA	594	UUGAAGCA CUGAUGAG GNNNNNNNNC CGAA AUCACCUA	4750
3719	AGGUGAUUU GCUUCAAG	595	CUUGAAGC CUGAUGAG GNNNNNNNNC CGAA AAUCACCU	4751
3723	GAUUUGCUU CAAGCAAA	596	UUUGCUUG CUGAUGAG GNNNNNNNNC CGAA AGCAAAUC	4752
3724	AUUUGCUUC AAGCAAAU	597	AUUUGCUU CUGAUGAG GNNNNNNNNC CGAA AAGCAAAU	4753
3735	GCAAAUGUA CAACAGGA	598	UCCUGUUG CUGAUGAG GNNNNNNNNC CGAA ACAUUUGC	4754
3748	AGGAUGGUA AAGACUAC	599	GUAGUCUU CUGAUGAG GNNNNNNNNC CGAA ACCAUCCU	4755
3755	UAAAGACUA CAUCCCAA	600	UUGGGAUG CUGAUGAG GNNNNNNNNC CGAA AGUCUUUA	4756
3759	GACUACAUC CCAAUCAA	601	UUGAUUGG CUGAUGAG GNNNNNNNNC CGAA AUGUAGUC	4757
3765	AUCCCAAUC AAUGCCAU	602	AUGGCAUU CUGAUGAG GNNNNNNNNC CGAA AUUGGGAU	4758
3774	AAUGCCAUA CUGACAGG	603	CCUGUCAG CUGAUGAG GNNNNNNNNC CGAA AUGGCAUU	4759
3787	CAGGAAAUA GUGGGUUU	604	AAACCCAC CUGAUGAG GNNNNNNNNC CGAA AUUUCCUG	4760
3794	UAGUGGGUU UACAUACU	605	AGUAUGUA CUGAUGAG GNNNNNNNNC CGAA ACCCACUA	4761
3795	AGUGGGUUU ACAUACUC	606	GAGUAUGU CUGAUGAG GNNNNNNNNC CGAA AACCCACU	4762
3796	GUGGGUUUA CAUACUCA	607	UGAGUAUG CUGAUGAG GNNNNNNNNC CGAA AAACCCAC	4763
3800	GUUUACAUA CUCAACUC	608	GAGUUGAG CUGAUGAG GNNNNNNNNC CGAA AUGUAAAC	4764
3803	UACAUACUC AACUCCUG	609	CAGGAGUU CUGAUGAG GNNNNNNNNC CGAA AGUAUGUA	4765
3808	ACUCAACUC CUGCCUUC	610	GAAGGCAG CUGAUGAG GNNNNNNNNC CGAA AGUUGAGU	4766
3815	UCCUGCCUU CUCUGAGG	611	CCUCAGAG CUGAUGAG GNNNNNNNNC CGAA AGGCAGGA	4767
3816	CCUGCCUUC UCUGAGGA	612	UCCUCAGA CUGAUGAG GNNNNNNNNC CGAA AAGGCAGG	4768
3818	UGCCUUCUC UGAGGACU	613	AGUCCUCA CUGAUGAG GNNNNNNNNC CGAA AGAAGGCA	4769
3827	UGAGGACUU CUUCAAGG	614	CCUUGAAG CUGAUGAG GNNNNNNNNC CGAA AGUCCUCA	4770
3828	GAGGACUUC UUCAAGGA	615	UCCUUGAA CUGAUGAG GNNNNNNNNC CGAA AAGUCCUC	4771
3830	GGACUUCUU CAAGGAAA	616	UUUCCUUG CUGAUGAG GNNNNNNNNC CGAA AGAAGUCC	4772
3831	GACUUCUUC AAGGAAAG	617	CUUUCCUU CUGAUGAG GNNNNNNNNC CGAA AAGAAGUC	4773
3841	AGGAAAGUA UUUCAGCU	618	AGCUGAAA CUGAUGAG GNNNNNNNNC CGAA ACUUUCCU	4774
3843	GAAAGUAUU UCAGCUCC	619	GGAGCUGA CUGAUGAG GNNNNNNNNC CGAA AUACUUUC	4775
3844	AAAGUAUUU CAGCUCCG	620	CGGAGCUG CUGAUGAG GNNNNNNNNC CGAA AAUACUUU	4776
3845	AAGUAUUUC AGCUCCGA	621	UCGGAGCU CUGAUGAG GNNNNNNNNC CGAA AAAUACUU	4777
3850	UUUCAGCUC CGAAGUUU	622	AAACUUCG CUGAUGAG GNNNNNNNNC CGAA AGCUGAAA	4778
3857	UCCGAAGUU UAAUUCAG	623	CUGAAUUA CUGAUGAG GNNNNNNNNC CGAA ACUUCGGA	4779
3858	CCGAAGUUU AAUUCAGG	624	CCUGAAUU CUGAUGAG GNNNNNNNNC CGAA AACUUCGG	4780
3859	CGAAGUUUA AUUCAGGA	625	UCCUGAAU CUGAUGAG GNNNNNNNNC CGAA AAACUUCG	4781
3862	AGUUUAAUU CAGGAAGC	626	GCUUCCUG CUGAUGAG GNNNNNNNNC CGAA AUUAAACU	4782
3863	GUUUAAUUC AGGAAGCU	627	AGCUUCCU CUGAUGAG GNNNNNNNNC CGAA AAUUAAAC	4783
3872	AGGAAGCUC UGAUGAUG	628	CAUCAUCA CUGAUGAG GNNNNNNNNC CGAA AGCUUCCU	4784
3882	GAUGAUGUC AGAUAUGU	629	ACAUAUCU CUGAUGAG GNNNNNNNNC CGAA ACAUCAUC	4785
3887	UGUCAGAUA UGUAAAUG	630	CAUUUACA CUGAUGAG GNNNNNNNNC CGAA AUCUGACA	4786
3891	AGAUAUGUA AAUGCUUU	631	AAAGCAUU CUGAUGAG GNNNNNNNNC CGAA ACAUAUCU	4787
3898	UAAAUGCUU UCAAGUUC	632	GAACUUGA CUGAUGAG GNNNNNNNNC CGAA AGCAUUUA	4788
3899	AAAUGCUUU CAAGUUCA	633	UGAACUUG CUGAUGAG GNNNNNNNNC CGAA AAGCAUUU	4789
3900	AAUGCUUUC AAGUUCAU	634	AUGAACUU CUGAUGAG GNNNNNNNNC CGAA AAAGCAUU	4790
3905	UUUCAAGUU CAUGAGCC	635	GGCUCAUG CUGAUGAG GNNNNNNNNC CGAA ACUUGAAA	4791
3906	UUCAAGUUC AUGAGCCU	636	AGGCUCAU CUGAUGAG GNNNNNNNNC CGAA AACUUGAA	4792
3924	GAAAGAAUC AAAACCUU	637	AAGGUUUU CUGAUGAG GNNNNNNNNC CGAA AUUCUUUC	4793
3932	CAAAACCUU UGAAGAAC	638	GUUCUUCA CUGAUGAG GNNNNNNNNC CGAA AGGUUUUG	4794
3933	AAAACCUUU GAAGAACU	639	AGUUCUUC CUGAUGAG GNNNNNNNNC CGAA AAGGUUUU	4795
3942	GAAGAACUU UUACCGAA	640	UUCGGUAA CUGAUGAG GNNNNNNNNC CGAA AGUUCUUC	4796
3943	AAGAACUUU UACCGAAU	641	AUUCGGUA CUGAUGAG GNNNNNNNNC CGAA AAGUUCUU	4797
3944	AGAACUUUU ACCGAAUG	642	CAUUCGGU CUGAUGAG GNNNNNNNNC CGAA AAAGUUCU	4798
3945	GAACUUUUA CCGAAUGC	643	GCAUUCGG CUGAUGAG GNNNNNNNNC CGAA AAAAGUUC	4799
3959	UGCCACCUC CAUGUUUG	644	CAAACAUG CUGAUGAG GNNNNNNNNC CGAA AGGUGGCA	4800
3965	CUCCAUGUU UGAUGACU	645	AGUCAUCA CUGAUGAG GNNNNNNNNC CGAA ACAUGGAG	4801
3966	UCCAUGUUU GAUGACUA	646	UAGUCAUC CUGAUGAG GNNNNNNNNC CGAA AACAUGGA	4802
3974	UGAUGACUA CCAGGGCG	647	CGCCCUGG CUGAUGAG GNNNNNNNNC CGAA AGUCAUCA	4803
3994	GCAGCACUC UGUUGGCC	648	GGCCAACA CUGAUGAG GNNNNNNNNC CGAA AGUGCUGC	4804
3998	CACUCUGUU GGCCUCUC	649	GAGAGGCC CUGAUGAG GNNNNNNNNC CGAA ACAGAGUG	4805
4004	GUUGGCCUC UCCCAUGC	650	GCAUGGGA CUGAUGAG GNNNNNNNNC CGAA AGGCCAAC	4806
4006	UGGCCUCUC CCAUGCUG	651	CAGCAUGG CUGAUGAG GNNNNNNNNC CGAA AGAGGCCA	4807
4022	GAAGCGCUU CACCUGGA	652	UCCAGGUG CUGAUGAG GNNNNNNNNC CGAA AGCGCUUC	4808
4023	AAGCGCUUC ACCUGGAC	653	GUCCAGGU CUGAUGAG GNNNNNNNNC CGAA AAGCGCUU	4809
4052	CAAGGCCUC GCUCAAGA	654	UCUUGAGC CUGAUGAG GNNNNNNNNC CGAA AGGCCUUG	4810
4056	GCCUCGCUC AAGAUUGA	655	UCAAUCUU CUGAUGAG GNNNNNNNNC CGAA AGCGAGGC	4811
4062	CUCAAGAUU GACUUGAG	656	CUCAAGUC CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	4812
4067	GAUUGACUU GAGAGUAA	657	UUACUCUC CUGAUGAG GNNNNNNNNC CGAA AGUCAAUC	4813
4074	UUGAGAGUA ACCAGUAA	658	UUACUGGU CUGAUGAG GNNNNNNNNC CGAA ACUCUCAA	4814
4081	UAACCAGUA AAAGUAAG	659	CUUACUUU CUGAUGAG GNNNNNNNNC CGAA ACUGGUUA	4815
4087	GUAAAAGUA AGGAGUCG	660	CGACUCCU CUGAUGAG GNNNNNNNNC CGAA ACUUUUAC	4816
4094	UAAGGAGUC GGGGCUGU	661	ACAGCCCC CUGAUGAG GNNNNNNNNC CGAA ACUCCUUA	4817
4103	GGGGCUGUC UGAUGUCA	662	UGACAUCA CUGAUGAG GNNNNNNNNC CGAA ACAGCCCC	4818
4110	UCUGAUGUC AGCAGGCC	663	GGCCUGCU CUGAUGAG GNNNNNNNNC CGAA ACAUCAGA	4819
4123	GGCCCAGUU UCUGCCAU	664	AUGGCAGA CUGAUGAG GNNNNNNNNC CGAA ACUGGGCC	4820
4124	GCCCAGUUU CUGCCAUU	665	AAUGGCAG CUGAUGAG GNNNNNNNNC CGAA AACUGGGC	4821
4125	CCCAGUUUC UGCCAUUC	666	GAAUGGCA CUGAUGAG GNNNNNNNNC CGAA AAACUGGG	4822
4132	UCUGCCAUU CCAGCUGU	667	ACAGCUGG CUGAUGAG GNNNNNNNNC CGAA AUGGCAGA	4823
4133	CUGCCAUUC CAGCUGUG	668	CACAGCUG CUGAUGAG GNNNNNNNNC CGAA AAUGGCAG	4824
4149	GGGCACGUC AGCGAAGG	669	CCUUCGCU CUGAUGAG GNNNNNNNNC CGAA ACGUGCCC	4825
4169	GCGCAGGUU CACCUACG	670	CGUAGGUG CUGAUGAG GNNNNNNNNC CGAA ACCUGCGC	4826
4170	CGCAGGUUC ACCUACGA	671	UCGUAGGU CUGAUGAG GNNNNNNNNC CGAA AACCUGCG	4827
4175	GUUCACCUA CGACCACG	672	CGUGGUCG CUGAUGAG GNNNNNNNNC CGAA AGGUGAAC	4828
4203	AGGAAAAUC GCGUGCUG	673	CAGCACGC CUGAUGAG GNNNNNNNNC CGAA AUUUUCCU	4829
4214	GUGCUGCUC CCCGCCCC	674	GGGGCGGG CUGAUGAG GNNNNNNNNC CGAA AGCAGCAC	4830
4229	CCCAGACUA CAACUCGG	675	CCGAGUUG CUGAUGAG GNNNNNNNNC CGAA AGUCUGGG	4831
4235	CUACAACUC GGUGGUCC	676	GGACCACC CUGAUGAG GNNNNNNNNC CGAA AGUUGUAG	4832
4242	UCGGUGGUC CUGUACUC	677	GAGUACAG CUGAUGAG GNNNNNNNNC CGAA ACCACCGA	4833
4247	GGUCCUGUA CUCCACCC	678	GGGUGGAG CUGAUGAG GNNNNNNNNC CGAA ACAGGACC	4834
4250	CCUGUACUC CACCCCAC	679	GUGGGGUG CUGAUGAG GNNNNNNNNC CGAA AGUACAGG	4835
4263	CCACCCAUC UAGAGUUU	680	AAACUCUA CUGAUGAG GNNNNNNNNC CGAA AUGGGUGG	4836
4265	ACCCAUCUA GAGUUUGA	681	UCAAACUC CUGAUGAG GNNNNNNNNC CGAA AGAUGGGU	4837
4270	UCUAGAGUU UGACACGA	682	UCGUGUCA CUGAUGAG GNNNNNNNNC CGAA ACUCUAGA	4838
4271	CUAGAGUUU GACACGAA	683	UUCGUGUC CUGAUGAG GNNNNNNNNC CGAA AACUCUAG	4839
4284	CGAAGCCUU AUUUCUAG	684	CUAGAAAU CUGAUGAG GNNNNNNNNC CGAA AGGCUUCG	4840
4285	GAAGCCUUA UUUCUAGA	685	UCUAGAAA CUGAUGAG GNNNNNNNNC CGAA AAGGCUUC	4841
4287	AGCCUUAUU UCUAGAAG	686	CUUCUAGA CUGAUGAG GNNNNNNNNC CGAA AUAAGGCU	4842
4288	GCCUUAUUU CUAGAAGC	687	GCUUCUAG CUGAUGAG GNNNNNNNNC CGAA AAUAAGGC	4843
4289	CCUUAUUUC UAGAAGCA	688	UGCUUCUA CUGAUGAG GNNNNNNNNC CGAA AAAUAAGG	4844
4291	UUAUUUCUA GAAGCACA	689	UGUGCUUC CUGAUGAG GNNNNNNNNC CGAA AGAAAUAA	4845
4305	ACAUGUGUA UUUAUACC	690	GGUAUAAA CUGAUGAG GNNNNNNNNC CGAA ACACAUGU	4846
4307	AUGUGUAUU UAUACCCC	691	GGGGUAUA CUGAUGAG GNNNNNNNNC CGAA AUACACAU	4847
4308	UGUGUAUUU AUACCCCC	692	GGGGGUAU CUGAUGAG GNNNNNNNNC CGAA AAUACACA	4848
4309	GUGUAUUUA UACCCCCA	693	UGGGGGUA CUGAUGAG GNNNNNNNNC CGAA AAAUACAC	4849
4311	GUAUUUAUA CCCCCAGG	694	CCUGGGGG CUGAUGAG GNNNNNNNNC CGAA AUAAAUAC	4850
4325	AGGAAACUA GCUUUUGC	695	GCAAAAGC CUGAUGAG GNNNNNNNNC CGAA AGUUUCCU	4851
4329	AACUAGCUU UUGCCAGU	696	ACUGGCAA CUGAUGAG GNNNNNNNNC CGAA AGCUAGUU	4852
4330	ACUAGCUUU UGCCAGUA	697	UACUGGCA CUGAUGAG GNNNNNNNNC CGAA AAGCUAGU	4853
4331	CUAGCUUUU GCCAGUAU	698	AUACUGGC CUGAUGAG GNNNNNNNNC CGAA AAAGCUAG	4854
4338	UUGCCAGUA UUAUGCAU	699	AUGCAUAA CUGAUGAG GNNNNNNNNC CGAA ACUGGCAA	4855
4340	GCCAGUAUU AUGCAUAU	700	AUAUGCAU CUGAUGAG GNNNNNNNNC CGAA AUACUGGC	4856
4341	CCAGUAUUA UGCAUAUA	701	UAUAUGCA CUGAUGAG GNNNNNNNNC CGAA AAUACUGG	4857
4347	UUAUGCAUA UAUAAGUU	702	AACUUAUA CUGAUGAG GNNNNNNNNC CGAA AUGCAUAA	4858
4349	AUGCAUAUA UAAGUUUA	703	UAAACUUA CUGAUGAG GNNNNNNNNC CGAA AUAUGCAU	4859
4351	GCAUAUAUA AGUUUACA	704	UGUAAACU CUGAUGAG GNNNNNNNNC CGAA AUAUAUGC	4860
4355	AUAUAAGUU UACACCUU	705	AAGGUGUA CUGAUGAG GNNNNNNNNC CGAA ACUUAUAU	4861
4356	UAUAAGUUU ACACCUUU	706	AAAGGUGU CUGAUGAG GNNNNNNNNC CGAA AACUUAUA	4862
4357	AUAAGUUUA CACCUUUA	707	UAAAGGUG CUGAUGAG GNNNNNNNNC CGAA AAACUUAU	4863
4363	UUACACCUU UAUCUUUC	708	GAAAGAUA CUGAUGAG GNNNNNNNNC CGAA AGGUGUAA	4864
4364	UACACCUUU AUCUUUCC	709	GGAAAGAU CUGAUGAG GNNNNNNNNC CGAA AAGGUGUA	4865
4365	ACACCUUUA UCUUUCCA	710	UGGAAAGA CUGAUGAG GNNNNNNNNC CGAA AAAGGUGU	4866
4367	ACCUUUAUC UUUCCAUG	711	CAUGGAAA CUGAUGAG GNNNNNNNNC CGAA AUAAAGGU	4867
4369	CUUUAUCUU UCCAUGGG	712	CCCAUGGA CUGAUGAG GNNNNNNNNC CGAA AGAUAAAG	4868
4370	UUUAUCUUU CCAUGGGA	713	UCCCAUGG CUGAUGAG GNNNNNNNNC CGAA AAGAUAAA	4869
4371	UUAUCUUUC CAUGGGAG	714	CUCCCAUG CUGAUGAG GNNNNNNNNC CGAA AAAGAUAA	4870
4389	CAGCUGCUU UUUGUGAU	715	AUCACAAA CUGAUGAG GNNNNNNNNC CGAA AGCAGCUG	4871
4390	AGCUGCUUU UUGUGAUU	716	AAUCACAA CUGAUGAG GNNNNNNNNC CGAA AAGCAGCU	4872
4391	GCUGCUUUU UGUGAUUU	717	AAAUCACA CUGAUGAG GNNNNNNNNC CGAA AAAGCAGC	4873
4392	CUGCUUUUU GUGAUUUU	718	AAAAUCAC CUGAUGAG GNNNNNNNNC CGAA AAAAGCAG	4874
4398	UUUGUGAUU UUUUUAAU	719	AUUAAAAA CUGAUGAG GNNNNNNNNC CGAA AUCACAAA	4875
4399	UUGUGAUUU UUUUAAUA	720	UAUUAAAA CUGAUGAG GNNNNNNNNC CGAA AAUCACAA	4876
4400	UGUGAUUUU UUUAAUAG	721	CUAUUAAA CUGAUGAG GNNNNNNNNC CGAA AAAUCACA	4877
4401	GUGAUUUUU UUAAUAGU	722	ACUAUUAA CUGAUGAG GNNNNNNNNC CGAA AAAAUCAC	4878
4402	UGAUUUUUU UAAUAGUG	723	CACUAUUA CUGAUGAG GNNNNNNNNC CGAA AAAAAUCA	4879
4403	GAUUUUUUU AAUAGUGC	724	GCACUAUU CUGAUGAG GNNNNNNNNC CGAA AAAAAAUC	4880
4404	AUUUUUUUA AUAGUGCU	725	AGCACUAU CUGAUGAG GNNNNNNNNC CGAA AAAAAAAU	4881
4407	UUUUUAAUA GUGCUUUU	726	AAAAGCAC CUGAUGAG GNNNNNNNNC CGAA AUUAAAAA	4882
4413	AUAGUGCUU UUUUUUUU	727	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AGCACUAU	4883
4414	UAGUGCUUU UUUUUUUU	728	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAGCACUA	4884
4415	AGUGCUUUU UUUUUUUG	729	CAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAGCACU	4885
4416	GUGCUUUUU UUUUUUGA	730	UCAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAGCAC	4886
4417	UGCUUUUUU UUUUUGAC	731	GUCAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAGCA	4887
4418	GCUUUUUUU UUUUGACU	732	AGUCAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAGC	4888
4419	GUUUUUUUU UUUGACUA	733	UAGUCAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAG	4889
4420	UUUUUUUUU UUGACUAA	734	UUAGUCAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	4890
4421	UUUUUUUUU UGACUAAC	735	GUUAGUCA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	4891
4422	UUUUUUUUU GACUAACA	736	UGUUAGUC CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	4892
4427	UUUUGACUA ACAAGAAU	737	AUUCUUGU CUGAUGAG GNNNNNNNNC CGAA AGUCAAAA	4893
4438	AAGAAUGUA ACUCCAGA	738	UCUGGAGU CUGAUGAG GNNNNNNNNC CGAA ACAUUCUU	4894
4442	AUGUAACUC CAGAUAGA	739	UCUAUCUG CUGAUGAG GNNNNNNNNC CGAA AGUUACAU	4895
4448	CUCCAGAUA GAGAAAUA	740	UAUUUCUC CUGAUGAG GNNNNNNNNC CGAA AUCUGGAG	4896
4456	AGAGAAAUA GUGACAAG	741	CUUGUCAC CUGAUGAG GNNNNNNNNC CGAA AUUUCUCU	4897
4476	AGAACACUA CUGCUAAA	742	UUUAGCAG CUGAUGAG GNNNNNNNNC CGAA AGUGUUCU	4898
4482	CUACUGCUA AAUCCUCA	743	UGAGGAUU CUGAUGAG GNNNNNNNNC CGAA AGCAGUAG	4899
4486	UGCUAAAUC CUCAUGUU	744	AACAUGAG CUGAUGAG GNNNNNNNNC CGAA AUUUAGCA	4900
4489	UAAAUCCUC AUGUUACU	745	AGUAACAU CUGAUGAG GNNNNNNNNC CGAA AGGAUUUA	4901
4494	CCUCAUGUU ACUCAGUG	746	CACUGAGU CUGAUGAG GNNNNNNNNC CGAA ACAUGAGG	4902
4495	CUCAUGUUA CUCAGUGU	747	ACACUGAG CUGAUGAG GNNNNNNNNC CGAA AACAUGAG	4903
4498	AUGUUACUC AGUGUUAG	748	CUAACACU CUGAUGAG GNNNNNNNNC CGAA AGUAACAU	4904
4504	CUCAGUGUU AGAGAAAU	749	AUUUCUCU CUGAUGAG GNNNNNNNNC CGAA ACACUGAG	4905
4505	UCAGUGUUA GAGAAAUC	750	GAUUUCUC CUGAUGAG GNNNNNNNNC CGAA AACACUGA	4906
4513	AGAGAAAUC CUUCCUAA	751	UUAGGAAG CUGAUGAG GNNNNNNNNC CGAA AUUUCUCU	4907
4516	GAAAUCCUU CCUAAACC	752	GGUUUAGG CUGAUGAG GNNNNNNNNC CGAA AGGAUUUC	4908
4517	AAAUCCUUC CUAAACCC	753	GGGUUUAG CUGAUGAG GNNNNNNNNC CGAA AAGGAUUU	4909
4520	UCCUUCCUA AACCCAAU	754	AUUGGGUU CUGAUGAG GNNNNNNNNC CGAA AGGAAGGA	4910
4533	CAAUGACUU CCCUGCUC	755	GAGCAGGG CUGAUGAG GNNNNNNNNC CGAA AGUCAUUG	4911
4534	AAUGACUUC CCUGCUCC	756	GGAGCAGG CUGAUGAG GNNNNNNNNC CGAA AAGUCAUU	4912
4541	UCCCUGCUC CAACCCCC	757	GGGGGUUG CUGAUGAG GNNNNNNNNC CGAA AGCAGGGA	4913
4557	CGCCACCUC AGGGCACG	758	CGUGCCCU CUGAUGAG GNNNNNNNNC CGAA AGGUGGCG	4914
4576	GGACCAGUU UGAUUGAG	759	CUCAAUCA CUGAUGAG GNNNNNNNNC CGAA ACUGGUCC	4915
4577	GACCAGUUU GAUUGAGG	760	CCUCAAUC CUGAUGAG GNNNNNNNNC CGAA AACUGGUC	4916
4581	AGUUUGAUU GAGGAGCU	761	AGCUCCUC CUGAUGAG GNNNNNNNNC CGAA AUCAAACU	4917
4598	GCACUGAUC ACCCAAUG	762	CAUUGGGU CUGAUGAG GNNNNNNNNC CGAA AUCAGUGC	4918
4610	CAAUGCAUC ACGUACCC	763	GGGUACGU CUGAUGAG GNNNNNNNNC CGAA AUGCAUUG	4919
4615	CAUCACGUA CCCCACUG	764	CAGUGGGG CUGAUGAG GNNNNNNNNC CGAA ACGUGAUG	4920
4664	AAGCCCGUU AGCCCCAG	765	CUGGGGCU CUGAUGAG GNNNNNNNNC CGAA ACGGGCUU	4921
4665	AGCCCGUUA GCCCCAGG	766	CCUGGGGC CUGAUGAG GNNNNNNNNC CGAA AACGGGCU	4922
4678	CAGGGGAUC ACUGGCUG	767	CAGCCAGU CUGAUGAG GNNNNNNNNC CGAA AUCCCCUG	4923
4700	AGCAACAUC UCGGGAGU	768	ACUCCCGA CUGAUGAG GNNNNNNNNC CGAA AUGUUGCU	4924
4702	CAACAUCUC GGGAGUCC	769	GGACUCCC CUGAUGAG GNNNNNNNNC CGAA AGAUGUUG	4925
4709	UCGGGAGUC CUCUAGCA	770	UGCUAGAG CUGAUGAG GNNNNNNNNC CGAA ACUCCCGA	4926
4712	GGAGUCCUC UAGCAGGC	771	GCCUGCUA CUGAUGAG GNNNNNNNNC CGAA AGGACUCC	4927
4714	AGUCCUCUA GCAGGCCU	772	AGGCCUGC CUGAUGAG GNNNNNNNNC CGAA AGAGGACU	4928
4723	GCAGGCCUA AGACAUGU	773	ACAUGUCU CUGAUGAG GNNNNNNNNC CGAA AGGCCUGC	4929
4802	GAAAGAAUU UGAGACGC	774	GCGUCUCA CUGAUGAG GNNNNNNNNC CGAA AUUCUUUC	4930
4803	AAAGAAUUU GAGACGCA	775	UGCGUCUC CUGAUGAG GNNNNNNNNC CGAA AAUUCUUU	4931
4840	ACGGGGCUC AGCAAUGC	776	GCAUUGCU CUGAUGAG GNNNNNNNNC CGAA AGCCCCGU	4932
4852	AAUGCCAUU UCAGUGGC	777	GCCACUGA CUGAUGAG GNNNNNNNNC CGAA AUGGCAUU	4933
4853	AUGCCAUUU CAGUGGCU	778	AGCCACUG CUGAUGAG GNNNNNNNNC CGAA AAUGGCAU	4934
4854	UGCCAUUUC AGUGGCUU	779	AAGCCACU CUGAUGAG GNNNNNNNNC CGAA AAAUGGCA	4935
4862	CAGUGGCUU CCCAGCUC	780	GAGCUGGG CUGAUGAG GNNNNNNNNC CGAA AGCCACUG	4936
4863	AGUGGCUUC CCAGCUCU	781	AGAGCUGG CUGAUGAG GNNNNNNNNC CGAA AAGCCACU	4937
4870	UCCCAGCUC UGACCCUU	782	AAGGGUCA CUGAUGAG GNNNNNNNNC CGAA AGCUGGGA	4938
4878	CUGACCCUU CUACAUUU	783	AAAUGUAG CUGAUGAG GNNNNNNNNC CGAA AGGGUCAG	4939
4879	UGACCCUUC UACAUUUG	784	CAAAUGUA CUGAUGAG GNNNNNNNNC CGAA AAGGGUCA	4940
4881	ACCCUUCUA CAUUUGAG	785	CUCAAAUG CUGAUGAG GNNNNNNNNC CGAA AGAAGGGU	4941
4885	UUCUACAUU UGAGGGCC	786	GGCCCUCA CUGAUGAG GNNNNNNNNC CGAA AUGUAGAA	4942
4886	UCUACAUUU GAGGGCCC	787	GGGCCCUC CUGAUGAG GNNNNNNNNC CGAA AAUGUAGA	4943
4929	GGGGACAUU UUCUGGAU	788	AUCCAGAA CUGAUGAG GNNNNNNNNC CGAA AUGUCCCC	4944
4930	GGGACAUUU UCUGGAUU	789	AAUCCAGA CUGAUGAG GNNNNNNNNC CGAA AAUGUCCC	4945
4931	GGACAUUUU CUGGAUUC	790	GAAUCCAG CUGAUGAG GNNNNNNNNC CGAA AAAUGUCC	4946
4932	GACAUUUUC UGGAUUCU	791	AGAAUCCA CUGAUGAG GNNNNNNNNC CGAA AAAAUGUC	4947
4938	UUCUGGAUU CUGGGAGG	792	CCUCCCAG CUGAUGAG GNNNNNNNNC CGAA AUCCAGAA	4948
4939	UCUGGAUUC UGGGAGGC	793	GCCUCCCA CUGAUGAG GNNNNNNNNC CGAA AAUCCAGA	4949
4963	GGACAAAUA UCUUUUUU	794	AAAAAAGA CUGAUGAG GNNNNNNNNC CGAA AUUUGUCC	4950
4965	ACAAAUAUC UUUUUUGG	795	CCAAAAAA CUGAUGAG GNNNNNNNNC CGAA AUAUUUGU	4951
4967	AAAUAUCUU UUUUGGAA	796	UUCCAAAA CUGAUGAG GNNNNNNNNC CGAA AGAUAUUU	4952
4968	AAUAUCUUU UUUGGAAC	797	GUUCCAAA CUGAUGAG GNNNNNNNNC CGAA AAGAUAUU	4953
4969	AUAUCUUUU UUGGAACU	798	AGUUCCAA CUGAUGAG GNNNNNNNNC CGAA AAAGAUAU	4954
4970	UAUCUUUUU UGGAACUA	799	UAGUUCCA CUGAUGAG GNNNNNNNNC CGAA AAAAGAUA	4955
4971	AUCUUUUUU GGAACUAA	800	UUAGUUCC CUGAUGAG GNNNNNNNNC CGAA AAAAAGAU	4956
4978	UUGGAACUA AAGCAAAU	801	AUUUGCUU CUGAUGAG GNNNNNNNNC CGAA AGUUCCAA	4957
4987	AAGCAAAUU UUAGACCU	802	AGGUCUAA CUGAUGAG GNNNNNNNNC CGAA AUUUGCUU	4958
4988	AGCAAAUUU UAGACCUU	803	AAGGUCUA CUGAUGAG GNNNNNNNNC CGAA AAUUUGCU	4959
4989	GCAAAUUUU AGACCUUU	804	AAAGGUCU CUGAUGAG GNNNNNNNNC CGAA AAAUUUGC	4960
4990	CAAAUUUUA GACCUUUA	805	UAAAGGUC CUGAUGAG GNNNNNNNNC CGAA AAAAUUUG	4961
4996	UUAGACCUU UACCUAUG	806	CAUAGGUA CUGAUGAG GNNNNNNNNC CGAA AGGUCUAA	4962
4997	UAGACCUUU ACCUAUGG	807	CCAUAGGU CUGAUGAG GNNNNNNNNC CGAA AAGGUCUA	4963
4998	AGACCUUUA CCUAUGGA	808	UCCAUAGG CUGAUGAG GNNNNNNNNC CGAA AAAGGUCU	4964
5002	CUUUACCUA UGGAAGUG	809	CACUUCCA CUGAUGAG GNNNNNNNNC CGAA AGGUAAAG	4965
5013	GAAGUGGUU CUAUGUCC	810	GGAGAUAG CUGAUGAG GNNNNNNNNC CGAA ACCACUUC	4966
5014	AAGUGGUUC UAUGUCCA	811	UGGACAUA CUGAUGAG GNNNNNNNNC CGAA AACCACUU	4967
5016	GUGGUUCUA UGUCCAUU	812	AAUGGACA CUGAUGAG GNNNNNNNNC CGAA AGAACCAC	4968
5020	UUCUAUGUC CAUUCUCA	813	UGAGAAUG CUGAUGAG GNNNNNNNNC CGAA ACAUAGAA	4969
5024	AUGUCCAUU CUCAUUCG	814	CGAAUGAG CUGAUGAG GNNNNNNNNC CGAA AUGGACAU	4970
5025	UGUCCAUUC UCAUUCGU	815	ACGAAUGA CUGAUGAG GNNNNNNNNC CGAA AAUGGACA	4971
5027	UCCAUUCUC AUUCGUGG	816	CCACGAAU CUGAUGAG GNNNNNNNNC CGAA AGAAUGGA	4972
5030	AUUCUCAUU CGUGGCAU	817	AUGCCACG CUGAUGAG GNNNNNNNNC CGAA AUGAGAAU	4973
5031	UUCUCAUUC GUGGCAUG	818	CAUGCCAC CUGAUGAG GNNNNNNNNC CGAA AAUGAGAA	4974
5041	UGGCAUGUU UUGAUUUG	819	CAAAUCAA CUGAUGAG GNNNNNNNNC CGAA ACAUGCCA	4975
5042	GGCAUGUUU UGAUUUGU	820	ACAAAUCA CUGAUGAG GNNNNNNNNC CGAA AACAUGCC	4976
5043	GCAUGUUUU GAUUUGUA	821	UACAAAUC CUGAUGAG GNNNNNNNNC CGAA AAACAUGC	4977
5047	GUUUUGAUU UGUAGCAC	822	GUGCUACA CUGAUGAG GNNNNNNNNC CGAA AUCAAAAC	4978
5048	UUUUGAUUU GUAGCACU	823	AGUGCUAC CUGAUGAG GNNNNNNNNC CGAA AAUCAAAA	4979
5051	UGAUUUGUA GCACUGAG	824	CUCAGUGC CUGAUGAG GNNNNNNNNC CGAA ACAAAUCA	4980
5069	GUGGCACUC AACUCUGA	825	UCAGAGUU CUGAUGAG GNNNNNNNNC CGAA AGUGCCAC	4981
5074	ACUCAACUC UGAGCCCA	826	UGGGCUCA CUGAUGAG GNNNNNNNNC CGAA AGUUGAGU	4982
5084	GAGCCCAUA CUUUUGGC	827	GCCAAAAG CUGAUGAG GNNNNNNNNC CGAA AUGGGCUC	4983
5087	CCCAUACUU UUGGCUCC	828	GGAGCCAA CUGAUGAG GNNNNNNNNC CGAA AGUAUGGG	4984
5088	CCAUACUUU UGGCUCCU	829	AGGAGCCA CUGAUGAG GNNNNNNNNC CGAA AAGUAUGG	4985
5089	CAUACUUUU GGCUCCUC	830	GAGGAGCC CUGAUGAG GNNNNNNNNC CGAA AAAGUAUG	4986
5094	UUUUGGCUC CUCUAGUA	831	UACUAGAG CUGAUGAG GNNNNNNNNC CGAA AGCCAAAA	4987
5097	UGGCUCCUC UAGUAAGA	832	UCUUACUA CUGAUGAG GNNNNNNNNC CGAA AGGAGCCA	4988
5099	GCUCCUCUA GUAAGAUG	833	CAUCUUAC CUGAUGAG GNNNNNNNNC CGAA AGAGGAGC	4989
5102	CCUCUAGUA AGAUGCAC	834	GUGCAUCU CUGAUGAG GNNNNNNNNC CGAA ACUAGAGG	4990
5119	UGAAAACUU AGCCAGAG	835	CUCUGGCU CUGAUGAG GNNNNNNNNC CGAA AGUUUUCA	4991
5120	GAAAACUUA GCCAGAGU	836	ACUCUGGC CUGAUGAG GNNNNNNNNC CGAA AAGUUUUC	4992
5129	GCCAGAGUU AGGUUGUC	837	GACAACCU CUGAUGAG GNNNNNNNNC CGAA ACUCUGGC	4993
5130	CCAGAGUUA GGUUGUCU	838	AGACAACC CUGAUGAG GNNNNNNNNC CGAA AACUCUGG	4994
5134	AGUUAGGUU GUCUCCAG	839	CUGGAGAC CUGAUGAG GNNNNNNNNC CGAA ACCUAACU	4995
5137	UAGGUUGUC UCCAGGCC	840	GGCCUGGA CUGAUGAG GNNNNNNNNC CGAA ACAACCUA	4996
5139	GGUUGUCUC CAGGCCAU	841	AUGGCCUG CUGAUGAG GNNNNNNNNC CGAA AGACAACC	4997
5156	GAUGGCCUU ACACUGAA	842	UUCAGUGU CUGAUGAG GNNNNNNNNC CGAA AGGCCAUC	4998
5157	AUGGCCUUA CACUGAAA	843	UUUCAGUG CUGAUGAG GNNNNNNNNC CGAA AAGGCCAU	4999
5170	GAAAAUGUC ACAUUCUA	844	UAGAAUGU CUGAUGAG GNNNNNNNNC CGAA ACAUUUUC	5000
5175	UGUCACAUU CUAUUUUG	845	CAAAAUAG CUGAUGAG GNNNNNNNNC CGAA AUGUGACA	5001
5176	GUCACAUUC UAUUUUGG	846	CCAAAAUA CUGAUGAG GNNNNNNNNC CGAA AAUGUGAC	5002
5178	CACAUUCUA UUUUGGGU	847	ACCCAAAA CUGAUGAG GNNNNNNNNC CGAA AGAAUGUG	5003
5180	CAUUCUAUU UUGGGUAU	848	AUACCCAA CUGAUGAG GNNNNNNNNC CGAA AUAGAAUG	5004
5181	AUUCUAUUU UGGGUAUU	849	AAUACCCA CUGAUGAG GNNNNNNNNC CGAA AAUAGAAU	5005
5182	UUCUAUUUU GGGUAUUA	850	UAAUACCC CUGAUGAG GNNNNNNNNC CGAA AAAUAGAA	5006
5187	UUUUGGGUA UUAAUAUA	851	UAUAUUAA CUGAUGAG GNNNNNNNNC CGAA ACCCAAAA	5007
5189	UUGGGUAUU AAUAUAUA	852	UAUAUAUU CUGAUGAG GNNNNNNNNC CGAA AUACCCAA	5008
5190	UGGGUAUUA AUAUAUAG	853	CUAUAUAU CUGAUGAG GNNNNNNNNC CGAA AAUACCCA	5009
5193	GUAUUAAUA UAUAGUCC	854	GGACUAUA CUGAUGAG GNNNNNNNNC CGAA AUUAAUAC	5010
5195	AUUAAUAUA UAGUCCAG	855	CUGGACUA CUGAUGAG GNNNNNNNNC CGAA AUAUUAAU	5011
5197	UAAUAUAUA GUCCAGAC	856	GUCUGGAC CUGAUGAG GNNNNNNNNC CGAA AUAUAUUA	5012
5200	UAUAUAGUC CAGACACU	857	AGUGUCUG CUGAUGAG GNNNNNNNNC CGAA ACUAUAUA	5013
5209	CAGACACUU AACUCAAU	858	AUUGAGUU CUGAUGAG GNNNNNNNNC CGAA AGUGUCUG	5014
5210	AGACACUUA ACUCAAUU	859	AAUUGAGU CUGAUGAG GNNNNNNNNC CGAA AAGUGUCU	5015
5214	ACUUAACUC AAUUUCUU	860	AAGAAAUU CUGAUGAG GNNNNNNNNC CGAA AGUUAAGU	5016
5218	AACUCAAUU UCUUGGUA	861	UACCAAGA CUGAUGAG GNNNNNNNNC CGAA AUUGAGUU	5017
5219	ACUCAAUUU CUUGGUAU	862	AUACCAAG CUGAUGAG GNNNNNNNNC CGAA AAUUGAGU	5018
5220	CUCAAUUUC UUGGUAUU	863	AAUACCAA CUGAUGAG GNNNNNNNNC CGAA AAAUUGAG	5019
5222	CAAUUUCUU GGUAUUAU	864	AUAAUACC CUGAUGAG GNNNNNNNNC CGAA AGAAAUUG	5020
5226	UUCUUGGUA UUAUUCUG	865	CAGAAUAA CUGAUGAG GNNNNNNNNC CGAA ACCAAGAA	5021
5228	CUUGGUAUU AUUCUGUU	866	AACAGAAU CUGAUGAG GNNNNNNNNC CGAA AUACCAAG	5022
5229	UUGGUAUUA UUCUGUUU	867	AAACAGAA CUGAUGAG GNNNNNNNNC CGAA AAUACCAA	5023
5231	GGUAUUAUU CUGUUUUG	868	CAAAACAG CUGAUGAG GNNNNNNNNC CGAA AUAAUACC	5024
5232	GUAUUAUUC UGUUUUGC	869	GCAAAACA CUGAUGAG GNNNNNNNNC CGAA AAUAAUAC	5025
5236	UAUUCUGUU UUGCACAG	870	CUGUGCAA CUGAUGAG GNNNNNNNNC CGAA ACAGAAUA	5026
5237	AUUCUGUUU UGCACAGU	871	ACUGUGCA CUGAUGAG GNNNNNNNNC CGAA AACAGAAU	5027
5238	UUCUGUUUU GCACAGUU	872	AACUGUGC CUGAUGAG GNNNNNNNNC CGAA AAACAGAA	5028
5246	UGCACAGUU AGUUGUGA	873	UCACAACU CUGAUGAG GNNNNNNNNC CGAA ACUGUGCA	5029
5247	GCACAGUUA GUUGUGAA	874	UUCACAAC CUGAUGAG GNNNNNNNNC CGAA AACUGUGC	5030
5250	CAGUUAGUU GUGAAAGA	875	UCUUUCAC CUGAUGAG GNNNNNNNNC CGAA ACUAACUG	5031
5284	AAUGCAGUC CUGAGGAG	876	CUCCUCAG CUGAUGAG GNNNNNNNNC CGAA ACUGCAUU	5032
5296	AGGAGAGUU UUCUCCAU	877	AUGGAGAA CUGAUGAG GNNNNNNNNC CGAA ACUCUCCU	5033
5297	GGAGAGUUU UCUCCAUA	878	UAUGGAGA CUGAUGAG GNNNNNNNNC CGAA AACUCUCC	5034
5298	GAGAGUUUU CUCCAUAU	879	AUAUGGAG CUGAUGAG GNNNNNNNNC CGAA AAACUCUC	5035
5299	AGAGUUUUC UCCAUAUC	880	GAUAUGGA CUGAUGAG GNNNNNNNNC CGAA AAAACUCU	5036
5301	AGUUUUCUC CAUAUCAA	881	UUGAUAUG CUGAUGAG GNNNNNNNNC CGAA AGAAAACU	5037
5305	UUCUCCAUA UCAAAACG	882	CGUUUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGAGAA	5038
5307	CUCCAUAUC AAAACGAG	883	CUCGUUUU CUGAUGAG GNNNNNNNNC CGAA AUAUGGAG	5039
5336	AAAAAGGUC AAUAAGGU	884	ACCUUAUU CUGAUGAG GNNNNNNNNC CGAA ACCUUUUU	5040
5340	AGGUCAAUA AGGUCAAG	885	CUUGACCU CUGAUGAG GNNNNNNNNC CGAA AUUGACCU	5041
5345	AAUAAGGUC AAGGGAAG	886	CUUCCCUU CUGAUGAG GNNNNNNNNC CGAA ACCUUAUU	5042
5361	GACCCCGUC UCUAUACC	887	GGUAUAGA CUGAUGAG GNNNNNNNNC CGAA ACGGGGUC	5043
5363	CCCCGUCUC UAUACCAA	888	UUGGUAUA CUGAUGAG GNNNNNNNNC CGAA AGACGGGG	5044
5365	CCGUCUCUA UACCAACC	889	GGUUGGUA CUGAUGAG GNNNNNNNNC CGAA AGAGACGG	5045
5367	GUCUCUAUA CCAACCAA	890	UUGGUUGG CUGAUGAG GNNNNNNNNC CGAA AUAGAGAC	5046
5382	AAACCAAUU CACCAACA	891	UGUUGGUG CUGAUGAG GNNNNNNNNC CGAA AUUGGUUU	5047
5383	AACCAAUUC ACCAACAC	892	GUGUUGGU CUGAUGAG GNNNNNNNNC CGAA AAUUGGUU	5048
5395	AACACAGUU GGGACCCA	893	UGGGUCCC CUGAUGAG GNNNNNNNNC CGAA ACUGUGUU	5049
5417	CAGGAAGUC AGUCACGU	894	ACGUGACU CUGAUGAG GNNNNNNNNC CGAA ACUUCCUG	5050
5421	AAGUCAGUC ACGUUUCC	895	GGAAACGU CUGAUGAG GNNNNNNNNC CGAA ACUGACUU	5051
5426	AGUCACGUU UCCUUUUC	896	GAAAAGGA CUGAUGAG GNNNNNNNNC CGAA ACGUGACU	5052
5427	GUCACGUUU CCUUUUCA	897	UGAAAAGG CUGAUGAG GNNNNNNNNC CGAA AACGUGAC	5053
5428	UCACGUUUC CUUUUCAU	898	AUGAAAAG CUGAUGAG GNNNNNNNNC CGAA AAACGUGA	5054
5431	CGUUUCCUU UUCAUUUA	899	UAAAUGAA CUGAUGAG GNNNNNNNNC CGAA AGGAAACG	5055
5432	GUUUCCUUU UCAUUUAA	900	UUAAAUGA CUGAUGAG GNNNNNNNNC CGAA AAGGAAAC	5056
5433	UUUCCUUUU CAUUUAAU	901	AUUAAAUG CUGAUGAG GNNNNNNNNC CGAA AAAGGAAA	5057
5434	UUCCUUUUC AUUUAAUG	902	CAUUAAAU CUGAUGAG GNNNNNNNNC CGAA AAAAGGAA	5058
5437	CUUUUCAUU UAAUGGGG	903	CCCCAUUA CUGAUGAG GNNNNNNNNC CGAA AUGAAAAG	5059
5438	UUUUCAUUU AAUGGGGA	904	UCCCCAUU CUGAUGAG GNNNNNNNNC CGAA AAUGAAAA	5060
5439	UUUCAUUUA AUGGGGAU	905	AUCCCCAU CUGAUGAG GNNNNNNNNC CGAA AAAUGAAA	5061
5448	AUGGGGAUU CCACUAUC	906	GAUAGUGG CUGAUGAG GNNNNNNNNC CGAA AUCCCCAU	5062
5449	UGGGGAUUC CACUAUCU	907	AGAUAGUG CUGAUGAG GNNNNNNNNC CGAA AAUCCCCA	5063
5454	AUUCCACUA UCUCACAC	908	GUGUGAGA CUGAUGAG GNNNNNNNNC CGAA AGUGGAAU	5064
5456	UCCACUAUC UCACACUA	909	UAGUGUGA CUGAUGAG GNNNNNNNNC CGAA AUAGUGGA	5065
5458	CACUAUCUC ACACUAAU	910	AUUAGUGU CUGAUGAG GNNNNNNNNC CGAA AGAUAGUG	5066
5464	CUCACACUA AUCUGAAA	911	UUUCAGAU CUGAUGAG GNNNNNNNNC CGAA AGUGUGAG	5067
5467	ACACUAAUC UGAAAGGA	912	UCCUUUCA CUGAUGAG GNNNNNNNNC CGAA AUUAGUGU	5068
5489	AAGAGCAUU AGCUGGCG	913	CGCCAGCU CUGAUGAG GNNNNNNNNC CGAA AUGCUCUU	5069
5490	AGAGCAUUA GCUGGCGC	914	GCGCCAGC CUGAUGAG GNNNNNNNNC CGAA AAUGCUCU	5070
5501	UGGCGCAUA UUAAGCAC	915	GUGCUUAA CUGAUGAG GNNNNNNNNC CGAA AUGCGCCA	5071
5503	GCGCAUAUU AAGCACUU	916	AAGUGCUU CUGAUGAG GNNNNNNNNC CGAA AUAUGCGC	5072
5504	CGCAUAUUA AGCACUUU	917	AAAGUGCU CUGAUGAG GNNNNNNNNC CGAA AAUAUGCG	5073
5511	UAAGCACUU UAAGCUCC	918	GGAGCUUA CUGAUGAG GNNNNNNNNC CGAA AGUGCUUA	5074
5512	AAGCACUUU AAGCUCCU	919	AGGAGCUU CUGAUGAG GNNNNNNNNC CGAA AAGUGCUU	5075
5513	AGCACUUUA AGCUCCUU	920	AAGGAGCU CUGAUGAG GNNNNNNNNC CGAA AAAGUGCU	5076
5518	UUUAAGCUC CUUGAGUA	921	UACUCAAG CUGAUGAG GNNNNNNNNC CGAA AGCUUAAA	5077
5521	AAGCUCCUU GAGUAAAA	922	UUUUACUC CUGAUGAG GNNNNNNNNC CGAA AGGAGCUU	5078
5526	CCUUGAGUA AAAAGGUG	923	CACCUUUU CUGAUGAG GNNNNNNNNC CGAA ACUCAAGG	5079
5537	AAGGUGGUA UGUAAUUU	924	AAAUUACA CUGAUGAG GNNNNNNNNC CGAA ACCACCUU	5080
5541	UGGUAUGUA AUUUAUGC	925	GCAUAAAU CUGAUGAG GNNNNNNNNC CGAA ACAUACCA	5081
5544	UAUGUAAUU UAUGCAAG	926	CUUGCAUA CUGAUGAG GNNNNNNNNC CGAA AUUACAUA	5082
5545	AUGUAAUUU AUGCAAGG	927	CCUUGCAU CUGAUGAG GNNNNNNNNC CGAA AAUUACAU	5083
5546	UGUAAUUUA UGCAAGGU	928	ACCUUGCA CUGAUGAG GNNNNNNNNC CGAA AAAUUACA	5084
5555	UGCAAGGUA UUUCUCCA	929	UGGAGAAA CUGAUGAG GNNNNNNNNC CGAA ACCUUGCA	5085
5557	CAAGGUAUU UCUCCAGU	930	ACUGGAGA CUGAUGAG GNNNNNNNNC CGAA AUACCUUG	5086
5558	AAGGUAUUU CUCCAGUU	931	AACUGGAG CUGAUGAG GNNNNNNNNC CGAA AAUACCUU	5087
5559	AGGUAUUUC UCCAGUUG	932	CAACUGGA CUGAUGAG GNNNNNNNNC CGAA AAAUACCU	5088
5561	GUAUUUCUC CAGUUGGG	933	CCCAACUG CUGAUGAG GNNNNNNNNC CGAA AGAAAUAC	5089
5566	UCUCCAGUU GGGACUCA	934	UGAGUCCC CUGAUGAG GNNNNNNNNC CGAA ACUGGAGA	5090
5573	UUGGGACUC AGGAUAUU	935	AAUAUCCU CUGAUGAG GNNNNNNNNC CGAA AGUCCCAA	5091
5579	CUCAGGAUA UUAGUUAA	936	UUAACUAA CUGAUGAG GNNNNNNNNC CGAA AUCCUGAG	5092
5581	CAGGAUAUU AGUUAAUG	937	CAUUAACU CUGAUGAG GNNNNNNNNC CGAA AUAUCCUG	5093
5582	AGGAUAUUA GUUAAUGA	938	UCAUUAAC CUGAUGAG GNNNNNNNNC CGAA AAUAUCCU	5094
5585	AUAUUAGUU AAUGAGCC	939	GGCUCAUU CUGAUGAG GNNNNNNNNC CGAA ACUAAUAU	5095
5586	UAUUAGUUA AUGAGCCA	940	UGGCUCAU CUGAUGAG GNNNNNNNNC CGAA AACUAAUA	5096
5596	UGAGCCAUC ACUAGAAG	941	CUUCUAGU CUGAUGAG GNNNNNNNNC CGAA AUGGCUCA	5097
5600	CCAUCACUA GAAGAAAA	942	UUUUCUUC CUGAUGAG GNNNNNNNNC CGAA AGUGAUGG	5098
5615	AAGCCCAUU UUCAACUG	943	CAGUUGAA CUGAUGAG GNNNNNNNNC CGAA AUGGGCUU	5099
5616	AGCCCAUUU UCAACUGC	944	GCAGUUGA CUGAUGAG GNNNNNNNNC CGAA AAUGGGCU	5100
5617	GCCCAUUUU CAACUGCU	945	AGCAGUUG CUGAUGAG GNNNNNNNNC CGAA AAAUGGGC	5101
5618	CCCAUUUUC AACUGCUU	946	AAGCAGUU CUGAUGAG GNNNNNNNNC CGAA AAAAUGGG	5102
5626	CAACUGCUU UGAAACUU	947	AAGUUUCA CUGAUGAG GNNNNNNNNC CGAA AGCAGUUG	5103
5627	AACUGCUUU GAAACUUG	948	CAAGUUUC CUGAUGAG GNNNNNNNNC CGAA AAGCAGUU	5104
5634	UUGAAACUU GCCUGGGG	949	CCCCAGGC CUGAUGAG GNNNNNNNNC CGAA AGUUUCAA	5105
5644	CCUGGGGUC UGAGCAUG	950	CAUGCUCA CUGAUGAG GNNNNNNNNC CGAA ACCCCAGG	5106
5661	AUGGGAAUA GGGAGACA	951	UGUCUCCC CUGAUGAG GNNNNNNNNC CGAA AUUCCCAU	5107
5674	GACAGGGUA GGAAAGGG	952	CCCUUUCC CUGAUGAG GNNNNNNNNC CGAA ACCCUGUC	5108
5688	GGGCGCCUA CUCUUCAG	953	CUGAAGAG CUGAUGAG GNNNNNNNNC CGAA AGGCGCCC	5109
5691	CGCCUACUC UUCAGGGU	954	ACCCUGAA CUGAUGAG GNNNNNNNNC CGAA AGUAGGCG	5110
5693	CCUACUCUU CAGGGUCU	955	AGACCCUG CUGAUGAG GNNNNNNNNC CGAA AGAGUAGG	5111
5694	CUACUCUUC AGGGUCUA	956	UAGACCCU CUGAUGAG GNNNNNNNNC CGAA AAGAGUAG	5112
5700	UUCAGGGUC UAAAGAUC	957	GAUCUUUA CUGAUGAG GNNNNNNNNC CGAA ACCCUGAA	5113
5702	CAGGGUCUA AAGAUCAA	958	UUGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGACCCUG	5114
5708	CUAAAGAUC AAGUGGGC	959	GCCCACUU CUGAUGAG GNNNNNNNNC CGAA AUCUUUAG	5115
5719	GUGGGCCUU GGAUCGCU	960	AGCGAUCC CUGAUGAG GNNNNNNNNC CGAA AGGCCCAC	5116
5724	CCUUGGAUC GCUAAGCU	961	AGCUUAGC CUGAUGAG GNNNNNNNNC CGAA AUCCAAGG	5117
5728	GGAUCGCUA AGCUGGCU	962	AGCCAGCU CUGAUGAG GNNNNNNNNC CGAA AGCGAUCC	5118
5737	AGCUGGCUC UGUUUGAU	963	AUCAAACA CUGAUGAG GNNNNNNNNC CGAA AGCCAGCU	5119
5741	GGCUCUGUU UGAUGCUA	964	UAGCAUCA CUGAUGAG GNNNNNNNNC CGAA ACAGAGCC	5120
5742	GCUCUGUUU GAUGCUAU	965	AUAGCAUC CUGAUGAG GNNNNNNNNC CGAA AACAGAGC	5121
5749	UUGAUGCUA UUUAUGCA	966	UGCAUAAA CUGAUGAG GNNNNNNNNC CGAA AGCAUCAA	5122
5751	GAUGCUAUU UAUGCAAG	967	CUUGCAUA CUGAUGAG GNNNNNNNNC CGAA AUAGCAUC	5123
5752	AUGCUAUUU AUGCAAGU	968	ACUUGCAU CUGAUGAG GNNNNNNNNC CGAA AAUAGCAU	5124
5753	UGCUAUUUA UGCAAGUU	969	AACUUGCA CUGAUGAG GNNNNNNNNC CGAA AAAUAGCA	5125
5761	AUGCAAGUU AGGGUCUA	970	UAGACCCU CUGAUGAG GNNNNNNNNC CGAA ACUUGCAU	5126
5762	UGCAAGUUA GGGUCUAU	971	AUAGACCC CUGAUGAG GNNNNNNNNC CGAA AACUUGCA	5127
5767	GUUAGGGUC UAUGUAUU	972	AAUACAUA CUGAUGAG GNNNNNNNNC CGAA ACCCUAAC	5128
5769	UAGGGUCUA UGUAUUUA	973	UAAAUACA CUGAUGAG GNNNNNNNNC CGAA AGACCCUA	5129
5773	GUCUAUGUA UUUAGGAU	974	AUCCUAAA CUGAUGAG GNNNNNNNNC CGAA ACAUAGAC	5130
5775	CUAUGUAUU UAGGAUGC	975	GCAUCCUA CUGAUGAG GNNNNNNNNC CGAA AUACAUAG	5131
5776	UAUGUAUUU AGGAUGCG	976	CGCAUCCU CUGAUGAG GNNNNNNNNC CGAA AAUACAUA	5132
5777	AUGUAUUUA GGAUGCGC	977	GCGCAUCC CUGAUGAG GNNNNNNNNC CGAA AAAUACAU	5133
5788	AUGCGCCUA CUCUUCAG	978	CUGAAGAG CUGAUGAG GNNNNNNNNC CGAA AGGCGCAU	5134
5791	CGCCUACUC UUCAGGGU	954	ACCCUGAA CUGAUGAG GNNNNNNNNC CGAA AGUAGGCG	5110
5793	CCUACUCUU CAGGGUCU	955	AGACCCUG CUGAUGAG GNNNNNNNNC CGAA AGAGUAGG	5111
5794	CUACUCUUC AGGGUCUA	956	UAGACCCU CUGAUGAG GNNNNNNNNC CGAA AAGAGUAG	5112
5800	UUCAGGGUC UAAAGAUC	957	GAUCUUUA CUGAUGAG GNNNNNNNNC CGAA ACCCUGAA	5113
5802	CAGGGUCUA AAGAUCAA	958	UUGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGACCCUG	5114
5808	CUAAAGAUC AAGUGGGC	959	GCCCACUU CUGAUGAG GNNNNNNNNC CGAA AUCUUUAG	5115
5819	GUGGGCCUU GGAUCGCU	960	AGCGAUCC CUGAUGAG GNNNNNNNNC CGAA AGGCCCAC	5116
5824	CCUUGGAUC GCUAAGCU	961	AGCUUAGC CUGAUGAG GNNNNNNNNC CGAA AUCCAAGG	5117
5828	GGAUCGCUA AGCUGGCU	962	AGCCAGCU CUGAUGAG GNNNNNNNNC CGAA AGCGAUCC	5118
5837	AGCUGGCUC UGUUUGAU	963	AUCAAACA CUGAUGAG GNNNNNNNNC CGAA AGCCAGCU	5119
5841	GGCUCUGUU UGAUGCUA	964	UAGCAUCA CUGAUGAG GNNNNNNNNC CGAA ACAGAGCC	5120
5842	GCUCUGUUU GAUGCUAU	965	AUAGCAUC CUGAUGAG GNNNNNNNNC CGAA AACAGAGC	5121
5849	UUGAUGCUA UUUAUGCA	966	UGCAUAAA CUGAUGAG GNNNNNNNNC CGAA AGCAUCAA	5122
5851	GAUGCUAUU UAUGCAAG	967	CUUGCAUA CUGAUGAG GNNNNNNNNC CGAA AUAGCAUC	5123
5852	AUGCUAUUU AUGCAAGU	968	ACUUGCAU CUGAUGAG GNNNNNNNNC CGAA AAUAGCAU	5124
5853	UGCUAUUUA UGCAAGUU	969	AACUUGCA CUGAUGAG GNNNNNNNNC CGAA AAAUAGCA	5125
5861	AUGCAAGUU AGGGUCUA	970	UAGACCCU CUGAUGAG GNNNNNNNNC CGAA ACUUGCAU	5126
5862	UGCAAGUUA GGGUCUAU	971	AUAGACCC CUGAUGAG GNNNNNNNNC CGAA AACUUGCA	5127
5867	GUUAGGGUC UAUGUAUU	972	AAUACAUA CUGAUGAG GNNNNNNNNC CGAA ACCCUAAC	5128
5869	UAGGGUCUA UGUAUUUA	973	UAAAUACA CUGAUGAG GNNNNNNNNC CGAA AGACCCUA	5129
5873	GUCUAUGUA UUUAGGAU	974	AUCCUAAA CUGAUGAG GNNNNNNNNC CGAA ACAUAGAC	5130
5875	CUAUGUAUU UAGGAUGU	979	ACAUCCUA CUGAUGAG GNNNNNNNNC CGAA AUACAUAG	5135
5876	UAUGUAUUU AGGAUGUC	980	GACAUCCU CUGAUGAG GNNNNNNNNC CGAA AAUACAUA	5136
5877	AUGUAUUUA GGAUGUCU	981	AGACAUCC CUGAUGAG GNNNNNNNNC CGAA AAAUACAU	5137
5884	UAGGAUGUC UGCACCUU	982	AAGGUGCA CUGAUGAG GNNNNNNNNC CGAA ACAUCCUA	5138
5892	CUGCACCUU CUGCAGCC	983	GGCUGCAG CUGAUGAG GNNNNNNNNC CGAA AGGUGCAG	5139
5893	UGCACCUUC UGCAGCCA	984	UGGCUGCA CUGAUGAG GNNNNNNNNC CGAA AAGGUGCA	5140
5904	CAGCCAGUC AGAAGCUG	985	CAGCUUCU CUGAUGAG GNNNNNNNNC CGAA ACUGGCUG	5141
5930	CAGUGGAUU GCUGCUUC	986	GAAGCAGC CUGAUGAG GNNNNNNNNC CGAA AUCCACUG	5142
5937	UUGCUGCUU CUUGGGGA	987	UCCCCAAG CUGAUGAG GNNNNNNNNC CGAA AGCAGCAA	5143
5938	UGCUGCUUC UUGGGGAG	988	CUCCCCAA CUGAUGAG GNNNNNNNNC CGAA AAGCAGCA	5144
5940	CUGCUUCUU GGGGAGAA	989	UUCUCCCC CUGAUGAG GNNNNNNNNC CGAA AGAAGCAG	5145
5953	AGAAGAGUA UGCUUCCU	990	AGGAAGCA CUGAUGAG GNNNNNNNNC CGAA ACUCUUCU	5146
5958	AGUAUGCUU CCUUUUAU	991	AUAAAAGG CUGAUGAG GNNNNNNNNC CGAA AGCAUACU	5147
5959	GUAUGCUUC CUUUUAUC	992	GAUAAAAG CUGAUGAG GNNNNNNNNC CGAA AAGCAUAC	5148
5962	UGCUUCCUU UUAUCCAU	993	AUGGAUAA CUGAUGAG GNNNNNNNNC CGAA AGGAAGCA	5149
5963	GCUUCCUUU UAUCCAUG	994	CAUGGAUA CUGAUGAG GNNNNNNNNC CGAA AAGGAAGC	5150
5964	CUUCCUUUU AUCCAUGU	995	ACAUGGAU CUGAUGAG GNNNNNNNNC CGAA AAAGGAAG	5151
5965	UUCCUUUUA UCCAUGUA	996	UACAUGGA CUGAUGAG GNNNNNNNNC CGAA AAAAGGAA	5152
5967	CCUUUUAUC CAUGUAAU	997	AUUACAUG CUGAUGAG GNNNNNNNNC CGAA AUAAAAGG	5153
5973	AUCCAUGUA AUUUAACU	998	AGUUAAAU CUGAUGAG GNNNNNNNNC CGAA ACAUGGAU	5154
5976	CAUGUAAUU UAACUGUA	999	UACAGUUA CUGAUGAG GNNNNNNNNC CGAA AUUACAUG	5155
5977	AUGUAAUUU AACUGUAG	1000	CUACAGUU CUGAUGAG GNNNNNNNNC CGAA AAUUACAU	5156
5978	UGUAAUUUA ACUGUAGA	1001	UCUACAGU CUGAUGAG GNNNNNNNNC CGAA AAAUUACA	5157
5984	UUAACUGUA GAACCUGA	1002	UCAGGUUC CUGAUGAG GNNNNNNNNC CGAA ACAGUUAA	5158
5996	CCUGAGCUC UAAGUAAC	1003	GUUACUUA CUGAUGAG GNNNNNNNNC CGAA AGCUCAGG	5159
5998	UGAGCUCUA AGUAACCG	1004	CGGUUACU CUGAUGAG GNNNNNNNNC CGAA AGAGCUCA	5160
6002	CUCUAAGUA ACCGAAGA	1005	UCUUCGGU CUGAUGAG GNNNNNNNNC CGAA ACUUAGAG	5161
6015	AAGAAUGUA UGCCUCUG	1006	CAGAGGCA CUGAUGAG GNNNNNNNNC CGAA ACAUUCUU	5162
6021	GUAUGCCUC UGUUCUUA	1007	UAAGAACA CUGAUGAG GNNNNNNNNC CGAA AGGCAUAC	5163
6025	GCCUCUGUU CUUAUGUG	1008	CACAUAAG CUGAUGAG GNNNNNNNNC CGAA ACAGAGGC	5164
6026	CCUCUGUUC UUAUGUGC	1009	GCACAUAA CUGAUGAG GNNNNNNNNC CGAA AACAGAGG	5165
6028	UCUGUUCUU AUGUGCCA	1010	UGGCACAU CUGAUGAG GNNNNNNNNC CGAA AGAACAGA	5166
6029	CUGUUCUUA UGUGCCAC	1011	GUGGCACA CUGAUGAG GNNNNNNNNC CGAA AAGAACAG	5167
6040	UGCCACAUC CUUGUUUA	1012	UAAACAAG CUGAUGAG GNNNNNNNNC CGAA AUGUGGCA	5168
6043	CACAUCCUU GUUUAAAG	1013	CUUUAAAC CUGAUGAG GNNNNNNNNC CGAA AGGAUGUG	5169
6046	AUCCUUGUU UAAAGGCU	1014	AGCCUUUA CUGAUGAG GNNNNNNNNC CGAA ACAAGGAU	5170
6047	UCCUUGUUU AAAGGCUC	1015	GAGCCUUU CUGAUGAG GNNNNNNNNC CGAA AACAAGGA	5171
6048	CCUUGUUUA AAGGCUCU	1016	AGAGCCUU CUGAUGAG GNNNNNNNNC CGAA AAACAAGG	5172
6055	UAAAGGCUC UCUGUAUG	1017	CAUACAGA CUGAUGAG GNNNNNNNNC CGAA AGCCUUUA	5173
6057	AAGGCUCUC UGUAUGAA	1018	UUCAUACA CUGAUGAG GNNNNNNNNC CGAA AGAGCCUU	5174
6061	CUCUCUGUA UGAAGAGA	1019	UCUCUUCA CUGAUGAG GNNNNNNNNC CGAA ACAGAGAG	5175
6079	GGGACCGUC AUCAGCAC	1020	GUGCUGAU CUGAUGAG GNNNNNNNNC CGAA ACGGUCCC	5176
6082	ACCGUCAUC AGCACAUU	1021	AAUGUGCU CUGAUGAG GNNNNNNNNC CGAA AUGACGGU	5177
6090	CAGCACAUU CCCUAGUG	1022	CACUAGGG CUGAUGAG GNNNNNNNNC CGAA AUGUGCUG	5178
6091	AGCACAUUC CCUAGUGA	1023	UCACUAGG CUGAUGAG GNNNNNNNNC CGAA AAUGUGCU	5179
6095	CAUUCCCUA GUGAGCCU	1024	AGGCUCAC CUGAUGAG GNNNNNNNNC CGAA AGGGAAUG	5180
6104	GUGAGCCUA CUGGCUCC	1025	GGAGCCAG CUGAUGAG GNNNNNNNNC CGAA AGGCUCAC	5181
6111	UACUGGCUC CUGGCAGC	1026	GCUGCCAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGUA	5182
6124	CAGCGGCUU UUGUGGAA	1027	UUCCACAA CUGAUGAG GNNNNNNNNC CGAA AGCCGCUG	5183
6125	AGCGGCUUU UGUGGAAG	1028	CUUCCACA CUGAUGAG GNNNNNNNNC CGAA AAGCCGCU	5184
6126	GCGGCUUUU GUGGAAGA	1029	UCUUCCAC CUGAUGAG GNNNNNNNNC CGAA AAAGCCGC	5185
6137	GGAAGACUC ACUAGCCA	1030	UGGCUAGU CUGAUGAG GNNNNNNNNC CGAA AGUCUUCC	5186
6141	GACUCACUA GCCAGAAG	1031	CUUCUGGC CUGAUGAG GNNNNNNNNC CGAA AGUGAGUC	5187
6166	GGGACAGUC CUCUCCAC	1032	GUGGAGAG CUGAUGAG GNNNNNNNNC CGAA ACUGUCCC	5188
6169	ACAGUCCUC UCCACCAA	1033	UUGGUGGA CUGAUGAG GNNNNNNNNC CGAA AGGACUGU	5189
6171	AGUCCUCUC CACCAAGA	1034	UCUUGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGGACU	5190
6181	ACCAAGAUC UAAAUCCA	1035	UGGAUUUA CUGAUGAG GNNNNNNNNC CGAA AUCUUGGU	5191
6183	CAAGAUCUA AAUCCAAA	1036	UUUGGAUU CUGAUGAG GNNNNNNNNC CGAA AGAUCUUG	5192
6187	AUCUAAAUC CAAACAAA	1037	UUUGUUUG CUGAUGAG GNNNNNNNNC CGAA AUUUAGAU	5193
6204	AGCAGGCUA GAGCCAGA	1038	UCUGGCUC CUGAUGAG GNNNNNNNNC CGAA AGCCUGCU	5194
6226	GGACAAAUC UUUGUUGU	1039	ACAACAAA CUGAUGAG GNNNNNNNNC CGAA AUUUGUCC	5195
6228	ACAAAUCUU UGUUGUUC	1040	GAACAACA CUGAUGAG GNNNNNNNNC CGAA AGAUUUGU	5196
6229	CAAAUCUUU GUUGUUCC	1041	GGAACAAC CUGAUGAG GNNNNNNNNC CGAA AAGAUUUG	5197
6232	AUCUUUGUU GUUCCUCU	1042	AGAGGAAC CUGAUGAG GNNNNNNNNC CGAA ACAAAGAU	5198
6235	UUUGUUGUU CCUCUUCU	1043	AGAAGAGG CUGAUGAG GNNNNNNNNC CGAA ACAACAAA	5199
6236	UUGUUGUUC CUCUUCUU	1044	AAGAAGAG CUGAUGAG GNNNNNNNNC CGAA AACAACAA	5200
6239	UUGUUCCUC UUCUUUAC	1045	GUAAAGAA CUGAUGAG GNNNNNNNNC CGAA AGGAACAA	5201
6241	GUUCCUCUU CUUUACAC	1046	GUGUAAAG CUGAUGAG GNNNNNNNNC CGAA AGAGGAAC	5202
6242	UUCCUCUUC UUUACACA	1047	UGUGUAAA CUGAUGAG GNNNNNNNNC CGAA AAGAGGAA	5203
6244	CCUCUUCUU UACACAUA	1048	UAUGUGUA CUGAUGAG GNNNNNNNNC CGAA AGAAGAGG	5204
6245	CUCUUCUUU ACACAUAC	1049	GUAUGUGU CUGAUGAG GNNNNNNNNC CGAA AAGAAGAG	5205
6246	UCUUCUUUA CACAUACG	1050	CGUAUGUG CUGAUGAG GNNNNNNNNC CGAA AAAGAAGA	5206
6252	UUACACAUA CGCAAACC	1051	GGUUUGCG CUGAUGAG GNNNNNNNNC CGAA AUGUGUAA	5207
6280	CUGGCAAUU UUAUAAAU	1052	AUUUAUAA CUGAUGAG GNNNNNNNNC CGAA AUUGCCAG	5208
6281	UGGCAAUUU UAUAAAUC	1053	GAUUUAUA CUGAUGAG GNNNNNNNNC CGAA AAUUGCCA	5209
6282	GGCAAUUUU AUAAAUCA	1054	UGAUUUAU CUGAUGAG GNNNNNNNNC CGAA AAAUUGCC	5210
6283	GCAAUUUUA UAAAUCAG	1055	CUGAUUUA CUGAUGAG GNNNNNNNNC CGAA AAAAUUGC	5211
6285	AAUUUUAUA AAUCAGGU	1056	ACCUGAUU CUGAUGAG GNNNNNNNNC CGAA AUAAAAUU	5212
6289	UUAUAAAUC AGGUAACU	1057	AGUUACCU CUGAUGAG GNNNNNNNNC CGAA AUUUAUAA	5213
6294	AAUCAGGUA ACUGGAAG	1058	CUUCCAGU CUGAUGAG GNNNNNNNNC CGAA ACCUGAUU	5214
6308	AAGGAGGUU AAACUCAG	1059	CUGAGUUU CUGAUGAG GNNNNNNNNC CGAA ACCUCCUU	5215
6309	AGGAGGUUA AACUCAGA	1060	UCUGAGUU CUGAUGAG GNNNNNNNNC CGAA AACCUCCU	5216
6314	GUUAAACUC AGAAAAAA	1061	UUUUUUCU CUGAUGAG GNNNNNNNNC CGAA AGUUUAAC	5217
6331	GAAGACCUC AGUCAAUU	1062	AAUUGACU CUGAUGAG GNNNNNNNNC CGAA AGGUCUUC	5218
6335	ACCUCAGUC AAUUCUCU	1063	AGAGAAUU CUGAUGAG GNNNNNNNNC CGAA ACUGAGGU	5219
6339	CAGUCAAUU CUCUACUU	1064	AAGUAGAG CUGAUGAG GNNNNNNNNC CGAA AUUGACUG	5220
6340	AGUCAAUUC UCUACUUU	1065	AAAGUAGA CUGAUGAG GNNNNNNNNC CGAA AAUUGACU	5221
6342	UCAAUUCUC UACUUUUU	1066	AAAAAGUA CUGAUGAG GNNNNNNNNC CGAA AGAAUUGA	5222
6344	AAUUCUCUA CUUUUUUU	1067	AAAAAAAG CUGAUGAG GNNNNNNNNC CGAA AGAGAAUU	5223
6347	UCUCUACUU UUUUUUUU	1068	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AGUAGAGA	5224
6348	CUCUACUUU UUUUUUUU	1069	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAGUAGAG	5225
6349	UCUACUUUU UUUUUUUU	1070	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAGUAGA	5226
6350	CUACUUUUU UUUUUUUU	1071	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAGUAG	5227
6351	UACUUUUUU UUUUUUUU	1072	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAGUA	5228
6352	ACUUUUUUU UUUUUUUU	1073	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAGU	5229
6353	CUUUUUUUU UUUUUUUU	1074	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAG	5230
6354	UUUUUUUUU UUUUUUUC	1075	GAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5231
6355	UUUUUUUUU UUUUUUCC	1076	GGAAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5232
6356	UUUUUUUUU UUUUUCCA	1077	UGGAAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5233
6357	UUUUUUUUU UUUUCCAA	1078	UUGGAAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5234
6358	UUUUUUUUU UUUCCAAA	1079	UUUGGAAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5235
6359	UUUUUUUUU UUCCAAAU	1080	AUUUGGAA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5236
6360	UUUUUUUUU UCCAAAUC	1081	GAUUUGGA CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5237
6361	UUUUUUUUU CCAAAUCA	1082	UGAUUUGG CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5238
6362	UUUUUUUUC CAAAUCAG	1083	CUGAUUUG CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5239
6368	UUCCAAAUC AGAUAAUA	1084	UAUUAUCU CUGAUGAG GNNNNNNNNC CGAA AUUUGGAA	5240
6373	AAUCAGAUA AUAGCCCA	1085	UGGGCUAU CUGAUGAG GNNNNNNNNC CGAA AUCUGAUU	5241
6376	CAGAUAAUA GCCCAGCA	1086	UGCUGGGC CUGAUGAG GNNNNNNNNC CGAA AUUAUCUG	5242
6388	CAGCAAAUA GUGAUAAC	1087	GUUAUCAC CUGAUGAG GNNNNNNNNC CGAA AUUUGCUG	5243
6394	AUAGUGAUA ACAAAUAA	1088	UUAUUUGU CUGAUGAG GNNNNNNNNC CGAA AUCACUAU	5244
6401	UAACAAAUA AAACCUUA	1089	UAAGGUUU CUGAUGAG GNNNNNNNNC CGAA AUUUGUUA	5245
6408	UAAAACCUU AGCUGUUC	1090	GAACAGCU CUGAUGAG GNNNNNNNNC CGAA AGGUUUUA	5246
6409	AAAACCUUA GCUGUUCA	1091	UGAACAGC CUGAUGAG GNNNNNNNNC CGAA AAGGUUUU	5247
6415	UUAGCUGUU CAUGUCUU	1092	AAGACAUG CUGAUGAG GNNNNNNNNC CGAA ACAGCUAA	5248
6416	UAGCUGUUC AUGUCUUG	1093	CAAGACAU CUGAUGAG GNNNNNNNNC CGAA AACAGCUA	5249
6421	GUUCAUGUC UUGAUUUC	1094	GAAAUCAA CUGAUGAG GNNNNNNNNC CGAA ACAUGAAC	5250
6423	UCAUGUCUU GAUUUCAA	1095	UUGAAAUC CUGAUGAG GNNNNNNNNC CGAA AGACAUGA	5251
6427	GUCUUGAUU UCAAUAAU	1096	AUUAUUGA CUGAUGAG GNNNNNNNNC CGAA AUCAAGAC	5252
6428	UCUUGAUUU CAAUAAUU	1097	AAUUAUUG CUGAUGAG GNNNNNNNNC CGAA AAUCAAGA	5253
6429	CUUGAUUUC AAUAAUUA	1098	UAAUUAUU CUGAUGAG GNNNNNNNNC CGAA AAAUCAAG	5254
6433	AUUUCAAUA AUUAAUUC	1099	GAAUUAAU CUGAUGAG GNNNNNNNNC CGAA AUUGAAAU	5255
6436	UCAAUAAUU AAUUCUUA	1100	UAAGAAUU CUGAUGAG GNNNNNNNNC CGAA AUUAUUGA	5256
6437	CAAUAAUUA AUUCUUAA	1101	UUAAGAAU CUGAUGAG GNNNNNNNNC CGAA AAUUAUUG	5257
6440	UAAUUAAUU CUUAAUCA	1102	UGAUUAAG CUGAUGAG GNNNNNNNNC CGAA AUUAAUUA	5258
6441	AAUUAAUUC UUAAUCAU	1103	AUGAUUAA CUGAUGAG GNNNNNNNNC CGAA AAUUAAUU	5259
6443	UUAAUUCUU AAUCAUUA	1104	UAAUGAUU CUGAUGAG GNNNNNNNNC CGAA AGAAUUAA	5260
6444	UAAUUCUUA AUCAUUAA	1105	UUAAUGAU CUGAUGAG GNNNNNNNNC CGAA AAGAAUUA	5261
6447	UUCUUAAUC AUUAAGAG	1106	CUCUUAAU CUGAUGAG GNNNNNNNNC CGAA AUUAAGAA	5262
6450	UUAAUCAUU AAGAGACC	1107	GGUCUCUU CUGAUGAG GNNNNNNNNC CGAA AUGAUUAA	5263
6451	UAAUCAUUA AGAGACCA	1108	UGGUCUCU CUGAUGAG GNNNNNNNNC CGAA AAUGAUUA	5264
6461	GAGACCAUA AUAAAUAC	1109	GUAUUUAU CUGAUGAG GNNNNNNNNC CGAA AUGGUCUC	5265
6464	ACCAUAAUA AAUACUCC	1110	GGAGUAUU CUGAUGAG GNNNNNNNNC CGAA AUUAUGGU	5266
6468	UAAUAAAUA CUCCUUUU	1111	AAAAGGAG CUGAUGAG GNNNNNNNNC CGAA AUUUAUUA	5267
6471	UAAAUACUC CUUUUCAA	1112	UUGAAAAG CUGAUGAG GNNNNNNNNC CGAA AGUAUUUA	5268
6474	AUACUCCUU UUCAAGAG	1113	CUCUUGAA CUGAUGAG GNNNNNNNNC CGAA AGGAGUAU	5269
6475	UACUCCUUU UCAAGAGA	1114	UCUCUUGA CUGAUGAG GNNNNNNNNC CGAA AAGGAGUA	5270
6476	ACUCCUUUU CAAGAGAA	1115	UUCUCUUG CUGAUGAG GNNNNNNNNC CGAA AAAGGAGU	5271
6477	CUCCUUUUC AAGAGAAA	1116	UUUCUCUU CUGAUGAG GNNNNNNNNC CGAA AAAAGGAG	5272
6497	AAAACCAUU AGAAUUGU	1117	ACAAUUCU CUGAUGAG GNNNNNNNNC CGAA AUGGUUUU	5273
6498	AAACCAUUA GAAUUGUU	1118	AACAAUUC CUGAUGAG GNNNNNNNNC CGAA AAUGGUUU	5274
6503	AUUAGAAUU GUUACUCA	1119	UGAGUAAC CUGAUGAG GNNNNNNNNC CGAA AUUCUAAU	5275
6506	AGAAUUGUU ACUCAGCU	1120	AGCUGAGU CUGAUGAG GNNNNNNNNC CGAA ACAAUUCU	5276
6507	GAAUUGUUA CUCAGCUC	1121	GAGCUGAG CUGAUGAG GNNNNNNNNC CGAA AACAAUUC	5277
6510	UUGUUACUC AGCUCCUU	1122	AAGGAGCU CUGAUGAG GNNNNNNNNC CGAA AGUAACAA	5278
6515	ACUCAGCUC CUUCAAAC	1123	GUUUGAAG CUGAUGAG GNNNNNNNNC CGAA AGCUGAGU	5279
6518	CAGCUCCUU CAAACUCA	1124	UGAGUUUG CUGAUGAG GNNNNNNNNC CGAA AGGAGCUG	5280
6519	AGCUCCUUC AAACUCAG	1125	CUGAGUUU CUGAUGAG GNNNNNNNNC CGAA AAGGAGCU	5281
6525	UUCAAACUC AGGUUUGU	1126	ACAAACCU CUGAUGAG GNNNNNNNNC CGAA AGUUUGAA	5282
6530	ACUCAGGUU UGUAGCAU	1127	AUGCUACA CUGAUGAG GNNNNNNNNC CGAA ACCUGAGU	5283
6531	CUCAGGUUU GUAGCAUA	1128	UAUGCUAC CUGAUGAG GNNNNNNNNC CGAA AACCUGAG	5284
6534	AGGUUUGUA GCAUACAU	1129	AUGUAUGC CUGAUGAG GNNNNNNNNC CGAA ACAAACCU	5285
6539	UGUAGCAUA CAUGAGUC	1130	GACUCAUG CUGAUGAG GNNNNNNNNC CGAA AUGCUACA	5286
6547	ACAUGAGUC CAUCCAUC	1131	GAUGGAUG CUGAUGAG GNNNNNNNNC CGAA ACUCAUGU	5287
6551	GAGUCCAUC CAUCAGUC	1132	GACUGAUG CUGAUGAG GNNNNNNNNC CGAA AUGGACUC	5288
6555	CCAUCCAUC AGUCAAAG	1133	CUUUGACU CUGAUGAG GNNNNNNNNC CGAA AUGGAUGG	5289
6559	CCAUCAGUC AAAGAAUG	1134	CAUUCUUU CUGAUGAG GNNNNNNNNC CGAA ACUGAUGG	5290
6570	AGAAUGGUU CCAUCUGG	1135	CCAGAUGG CUGAUGAG GNNNNNNNNC CGAA ACCAUUCU	5291
6571	GAAUGGUUC CAUCUGGA	1136	UCCAGAUG CUGAUGAG GNNNNNNNNC CGAA AACCAUUC	5292
6575	GGUUCCAUC UGGAGUCU	1137	AGACUCCA CUGAUGAG GNNNNNNNNC CGAA AUGGAACC	5293
6582	UCUGGAGUC UUAAUGUA	1138	UACAUUAA CUGAUGAG GNNNNNNNNC CGAA ACUCCAGA	5294
6584	UGGAGUCUU AAUGUAGA	1139	UCUACAUU CUGAUGAG GNNNNNNNNC CGAA AGACUCCA	5295
6585	GCAGUCUUA AUGUAGAA	1140	UUCUACAU CUGAUGAG GNNNNNNNNC CGAA AAGACUCC	5296
6590	CUUAAUGUA GAAAGAAA	1141	UUUCUUUC CUGAUGAG GNNNNNNNNC CGAA ACAUUAAG	5297
6609	UGGAGACUU GUAAUAAU	1142	AUUAUUAC CUGAUGAG GNNNNNNNNC CGAA AGUCUCCA	5298
6612	AGACUUGUA AUAAUGAG	1143	CUCAUUAU CUGAUGAG GNNNNNNNNC CGAA ACAAGUCU	5299
6615	CUUGUAAUA AUGAGCUA	1144	UAGCUCAU CUGAUGAG GNNNNNNNNC CGAA AUUACAAG	5300
6623	AAUGAGCUA GUUACAAA	1145	UUUGUAAC CUGAUGAG GNNNNNNNNC CGAA AGCUCAUU	5301
6626	GAGCUAGUU ACAAAGUG	1146	CACUUUGU CUGAUGAG GNNNNNNNNC CGAA ACUAGCUC	5302
6627	AGCUAGUUA CAAAGUGC	1147	GCACUUUG CUGAUGAG GNNNNNNNNC CGAA AACUAGCU	5303
6637	AAAGUGCUU GUUCAUUA	1148	UAAUGAAC CUGAUGAG GNNNNNNNNC CGAA AGCACUUU	5304
6640	GUGCUUGUU CAUUAAAA	1149	UUUUAAUG CUGAUGAG GNNNNNNNNC CGAA ACAAGCAC	5305
6641	UGCUUGUUC AUUAAAAU	1150	AUUUUAAU CUGAUGAG GNNNNNNNNC CGAA AACAAGCA	5306
6644	UUGUUCAUU AAAAUAGC	1151	GCUAUUUU CUGAUGAG GNNNNNNNNC CGAA AUGAACAA	5307
6645	UGUUCAUUA AAAUAGCA	1152	UGCUAUUU CUGAUGAG GNNNNNNNNC CGAA AAUGAACA	5308
6650	AUUAAAAUA GCACUGAA	1153	UUCAGUGC CUGAUGAG GNNNNNNNNC CGAA AUUUUAAU	5309
6662	CUGAAAAUU GAAACAUG	1154	CAUGUUUC CUGAUGAG GNNNNNNNNC CGAA AUUUUCAG	5310
6674	ACAUGAAUU AACUGAUA	1155	UAUCAGUU CUGAUGAG GNNNNNNNNC CGAA AUUCAUGU	5311
6675	CAUGAAUUA ACUGAUAA	1156	UUAUCAGU CUGAUGAG GNNNNNNNNC CGAA AAUUCAUG	5312
6682	UAACUGAUA AUAUUCCA	1157	UGGAAUAU CUGAUGAG GNNNNNNNNC CGAA AUCAGUUA	5313
6685	CUGAUAAUA UUCCAAUC	1158	GAUUGGAA CUGAUGAG GNNNNNNNNC CGAA AUUAUCAG	5314
6687	GAUAAUAUU CCAAUCAU	1159	AUGAUUGG CUGAUGAG GNNNNNNNNC CGAA AUAUUAUC	5315
6688	AUAAUAUUC CAAUCAUU	1160	AAUGAUUG CUGAUGAG GNNNNNNNNC CGAA AAUAUUAU	5316
6693	AUUCCAAUC AUUUGCCA	1161	UGGCAAAU CUGAUGAG GNNNNNNNNC CGAA AUUGGAAU	5317
6696	CCAAUCAUU UGCCAUUU	1162	AAAUGGCA CUGAUGAG GNNNNNNNNC CGAA AUGAUUGG	5318
6697	CAAUCAUUU GCCAUUUA	1163	UAAAUGGC CUGAUGAG GNNNNNNNNC CGAA AAUGAUUG	5319
6703	UUUGCCAUU UAUGACAA	1164	UUGUCAUA CUGAUGAG GNNNNNNNNC CGAA AUGGCAAA	5320
6704	UUGCCAUUU AUGACAAA	1165	UUUGUCAU CUGAUGAG GNNNNNNNNC CGAA AAUGGCAA	5321
6705	UGCCAUUUA UGACAAAA	1166	UUUUGUCA CUGAUGAG GNNNNNNNNC CGAA AAAUGGCA	5322
6719	AAAAUGGUU GGCACUAA	1167	UUAGUGCC CUGAUGAG GNNNNNNNNC CGAA ACCAUUUU	5323
6726	UUGGCACUA ACAAAGAA	1168	UUCUUUGU CUGAUGAG GNNNNNNNNC CGAA AGUGCCAA	5324
6743	CGAGCACUU CCUUUCAG	1169	CUGAAAGG CUGAUGAG GNNNNNNNNC CGAA AGUGCUCG	5325
6744	GAGCACUUC CUUUCAGA	1170	UCUGAAAG CUGAUGAG GNNNNNNNNC CGAA AAGUGCUC	5326
6747	CACUUCCUU UCAGAGUU	1171	AACUCUGA CUGAUGAG GNNNNNNNNC CGAA AGGAAGUG	5327
6748	ACUUCCUUU CAGAGUUU	1172	AAACUCUG CUGAUGAG GNNNNNNNNC CGAA AAGGAAGU	5328
6749	CUUCCUUUC AGAGUUUC	1173	GAAACUCU CUGAUGAG GNNNNNNNNC CGAA AAAGGAAG	5329
6755	UUCAGAGUU UCUGAGAU	1174	AUCUCAGA CUGAUGAG GNNNNNNNNC CGAA ACUCUGAA	5330
6756	UCAGAGUUU CUGAGAUA	1175	UAUCUCAG CUGAUGAG GNNNNNNNNC CGAA AACUCUGA	5331
6757	CAGAGUUUC UGAGAUAA	1176	UUAUCUCA CUGAUGAG GNNNNNNNNC CGAA AAACUCUG	5332
6764	UCUGAGAUA AUGUACGU	1177	ACGUACAU CUGAUGAG GNNNNNNNNC CGAA AUCUCAGA	5333
6769	GAUAAUGUA CGUGGAAC	1178	GUUCCACG CUGAUGAG GNNNNNNNNC CGAA ACAUUAUC	5334
6781	GGAACAGUC UGGGUGGA	1179	UCCACCCA CUGAUGAG GNNNNNNNNC CGAA ACUGUUCC	5335
6814	GUGCAAGUC UGUGUCUU	1180	AAGACACA CUGAUGAG GNNNNNNNNC CGAA ACUUGCAC	5336
6820	GUCUGUGUC UUGUCAGU	1181	ACUGACAA CUGAUGAG GNNNNNNNNC CGAA ACACAGAC	5337
6822	CUGUGUCUU GUCAGUCC	1182	GGACUGAC CUGAUGAG GNNNNNNNNC CGAA AGACACAG	5338
6825	UGUCUUGUC AGUCCAAG	1183	CUUGGACU CUGAUGAG GNNNNNNNNC CGAA ACAAGACA	5339
6829	UUGUCAGUC CAAGAAGU	1184	ACUUCUUG CUGAUGAG GNNNNNNNNC CGAA ACUGACAA	5340
6851	CGAGAUGUU AAUUUUAG	1185	CUAAAAUU CUGAUGAG GNNNNNNNNC CGAA ACAUCUCG	5341
6852	GAGAUGUUA AUUUUAGG	1186	CCUAAAAU CUGAUGAG GNNNNNNNNC CGAA AACAUCUC	5342
6855	AUGUUAAUU UUAGGGAC	1187	GUCCCUAA CUGAUGAG GNNNNNNNNC CGAA AUUAACAU	5343
6856	UGUUAAUUU UAGGGACC	1188	GGUCCCUA CUGAUGAG GNNNNNNNNC CGAA AAUUAACA	5344
6857	GUUAAUUUU AGGGACCC	1189	GGGUCCCU CUGAUGAG GNNNNNNNNC CGAA AAAUUAAC	5345
6858	UUAAUUUUA GGGACCCG	1190	CGGGUCCC CUGAUGAG GNNNNNNNNC CGAA AAAAUUAA	5346
6872	CCGUGCCUU GUUUCCUA	1191	UAGGAAAC CUGAUGAG GNNNNNNNNC CGAA AGGCACGG	5347
6875	UGCCUUGUU UCCUAGCC	1192	GGCUAGGA CUGAUGAG GNNNNNNNNC CGAA ACAAGGCA	5348
6876	GCCUUGUUU CCUAGCCC	1193	GGGCUAGG CUGAUGAG GNNNNNNNNC CGAA AACAAGGC	5349
6877	CCUUGUUUC CUAGCCCA	1194	UGGGCUAG CUGAUGAG GNNNNNNNNC CGAA AAACAAGG	5350
6880	UGUUUCCUA GCCCACAA	1195	UUGUGGGC CUGAUGAG GNNNNNNNNC CGAA AGGAAACA	5351
6901	GCAAACAUC AAACAGAU	1196	AUCUGUUU CUGAUGAG GNNNNNNNNC CGAA AUGUUUGC	5352
6910	AAACAGAUA CUCGCUAG	1197	CUAGCGAG CUGAUGAG GNNNNNNNNC CGAA AUCUGUUU	5353
6913	CAGAUACUC GCUAGCCU	1198	AGGCUAGC CUGAUGAG GNNNNNNNNC CGAA AGUAUCUG	5354
6917	UACUCGCUA GCCUCAUU	1199	AAUGAGGC CUGAUGAG GNNNNNNNNC CGAA AGCGAGUA	5355
6922	GCUAGCCUC AUUUAAAU	1200	AUUUAAAU CUGAUGAG GNNNNNNNNC CGAA AGGCUAGC	5356
6925	AGCCUCAUU UAAAUUGA	1201	UCAAUUUA CUGAUGAG GNNNNNNNNC CGAA AUGAGGCU	5357
6926	GCCUCAUUU AAAUUGAU	1202	AUCAAUUU CUGAUGAG GNNNNNNNNC CGAA AAUGAGGC	5358
6927	CCUCAUUUA AAUUGAUU	1203	AAUCAAUU CUGAUGAG GNNNNNNNNC CGAA AAAUGAGG	5359
6931	AUUUAAAUU GAUUAAAG	1204	CUUUAAUC CUGAUGAG GNNNNNNNNC CGAA AUUUAAAU	5360
6935	AAAUUGAUU AAAGGAGG	1205	CCUCCUUU CUGAUGAG GNNNNNNNNC CGAA AUCAAUUU	5361
6936	AAUUGAUUA AAGGAGGA	1206	UCCUCCUU CUGAUGAG GNNNNNNNNC CGAA AAUCAAUU	5362
6951	GAGUGCAUC UUUGGCCG	1207	CGGCCAAA CUGAUGAG GNNNNNNNNC CGAA AUGCACUC	5363
6953	GUGCAUCUU UGGCCGAC	1208	GUCGGCCA CUGAUGAG GNNNNNNNNC CGAA AGAUGCAC	5364
6954	UGCAUCUUU GGCCGACA	1209	UGUCGGCC CUGAUGAG GNNNNNNNNC CGAA AAGAUGCA	5365
6970	AGUGGUGUA ACUGUGUG	1210	CACACAGU CUGAUGAG GNNNNNNNNC CGAA ACACCACU	5366
7026	GUGGGUGUA UGUGUGUU	1211	AACACACA CUGAUGAG GNNNNNNNNC CGAA ACACCCAC	5367
7034	AUGUGUGUU UUGUGCAU	1212	AUGCACAA CUGAUGAG GNNNNNNNNC CGAA ACACACAU	5368
7035	UGUGUGUUU UGUGCAUA	1213	UAUGCACA CUGAUGAG GNNNNNNNNC CGAA AACACACA	5369
7036	GUGUGUUUU GUGCAUAA	1214	UUAUGCAC CUGAUGAG GNNNNNNNNC CGAA AAACACAC	5370
7043	UUGUGCAUA ACUAUUUA	1215	UAAAUAGU CUGAUGAG GNNNNNNNNC CGAA AUGCACAA	5371
7047	GCAUAACUA UUUAAGGA	1216	UCCUUAAA CUGAUGAG GNNNNNNNNC CGAA AGUUAUGC	5372
7049	AUAACUAUU UAAGGAAA	1217	UUUCCUUA CUGAUGAG GNNNNNNNNC CGAA AUAGUUAU	5373
7050	UAACUAUUU AAGGAAAC	1218	GUUUCCUU CUGAUGAG GNNNNNNNNC CGAA AAUAGUUA	5374
7051	AACUAUUUA AGGAAACU	1219	AGUUUCCU CUGAUGAG GNNNNNNNNC CGAA AAAUAGUU	5375
7065	ACUGGAAUU UUAAAGUU	1220	AACUUUAA CUGAUGAG GNNNNNNNNC CGAA AUUCCAGU	5376
7066	CUGGAAUUU UAAAGUUA	1221	UAACUUUA CUGAUGAG GNNNNNNNNC CGAA AAUUCCAG	5377
7067	UGGAAUUUU AAAGUUAC	1222	GUAACUUU CUGAUGAG GNNNNNNNNC CGAA AAAUUCCA	5378
7068	GGAAUUUUA AAGUUACU	1223	AGUAACUU CUGAUGAG GNNNNNNNNC CGAA AAAAUUCC	5379
7073	UUUAAAGUU ACUUUUAU	1224	AUAAAAGU CUGAUGAG GNNNNNNNNC CGAA ACUUUAAA	5380
7074	UUAAAGUUA CUUUUAUA	1225	UAUAAAAG CUGAUGAG GNNNNNNNNC CGAA AACUUUAA	5381
7077	AAGUUACUU UUAUACAA	1226	UUGUAUAA CUGAUGAG GNNNNNNNNC CGAA AGUAACUU	5382
7078	AGUUACUUU UAUACAAA	1227	UUUGUAUA CUGAUGAG GNNNNNNNNC CGAA AAGUAACU	5383
7079	GUUACUUUU AUACAAAC	1228	GUUUGUAU CUGAUGAG GNNNNNNNNC CGAA AAAGUAAC	5384
7080	UUACUUUUA UACAAACC	1229	GGUUUGUA CUGAUGAG GNNNNNNNNC CGAA AAAAGUAA	5385
7082	ACUUUUAUA CAAACCAA	1230	UUGGUUUG CUGAUGAG GNNNNNNNNC CGAA AUAAAAGU	5386
7095	CCAAGAAUA UAUGCUAC	1231	GUAGCAUA CUGAUGAG GNNNNNNNNC CGAA AUUCUUGG	5387
7097	AAGAAUAUA UGCUACAG	1232	CUGUAGCA CUGAUGAG GNNNNNNNNC CGAA AUAUUCUU	5388
7102	UAUAUGCUA CAGAUAUA	1233	UAUAUCUG CUGAUGAG GNNNNNNNNC CGAA AGCAUAUA	5389
7108	CUACAGAUA UAAGACAG	1234	CUGUCUUA CUGAUGAG GNNNNNNNNC CGAA AUCUGUAG	5390
7110	ACAGAUAUA AGACAGAC	1235	GUCUGUCU CUGAUGAG GNNNNNNNNC CGAA AUAUCUGU	5391
7124	GACAUGGUU UGGUCCUA	1236	UAGGACCA CUGAUGAG GNNNNNNNNC CGAA ACCAUGUC	5392
7125	ACAUGGUUU GGUCCUAU	1237	AUAGGACC CUGAUGAG GNNNNNNNNC CGAA AACCAUGU	5393
7129	GGUUUGGUC CUAUAUUU	1238	AAAUAUAG CUGAUGAG GNNNNNNNNC CGAA ACCAAACC	5394
7132	UUGGUCCUA UAUUUCUA	1239	UAGAAAUA CUGAUGAG GNNNNNNNNC CGAA AGGACCAA	5395
7134	GGUCCUAUA UUUCUAGU	1240	ACUAGAAA CUGAUGAG GNNNNNNNNC CGAA AUAGGACC	5396
7136	UCCUAUAUU UCUAGUCA	1241	UGACUAGA CUGAUGAG GNNNNNNNNC CGAA AUAUAGGA	5397
7137	CCUAUAUUU CUAGUCAU	1242	AUGACUAG CUGAUGAG GNNNNNNNNC CGAA AAUAUAGG	5398
7138	CUAUAUUUC UAGUCAUG	1243	CAUGACUA CUGAUGAG GNNNNNNNNC CGAA AAAUAUAG	5399
7140	AUAUUUCUA GUCAUGAU	1244	AUCAUGAC CUGAUGAG GNNNNNNNNC CGAA AGAAAUAU	5400
7143	UUUCUAGUC AUGAUGAA	1245	UUCAUCAU CUGAUGAG GNNNNNNNNC CGAA ACUAGAAA	5401
7155	AUGAAUGUA UUUUGUAU	1246	AUACAAAA CUGAUGAG GNNNNNNNNC CGAA ACAUUCAU	5402
7157	GAAUGUAUU UUGUAUAC	1247	GUAUACAA CUGAUGAG GNNNNNNNNC CGAA AUACAUUC	5403
7158	AAUGUAUUU UGUAUACC	1248	GGUAUACA CUGAUGAG GNNNNNNNNC CGAA AAUACAUU	5404
7159	AUGUAUUUU GUAUACCA	1249	UGGUAUAC CUGAUGAG GNNNNNNNNC CGAA AAAUACAU	5405
7162	UAUUUUGUA UACCAUCU	1250	AGAUGGUA CUGAUGAG GNNNNNNNNC CGAA ACAAAAUA	5406
7164	UUUUGUAUA CCAUCUUC	1251	GAAGAUGG CUGAUGAG GNNNNNNNNC CGAA AUACAAAA	5407
7169	UAUACCAUC UUCAUAUA	1252	UAUAUGAA CUGAUGAG GNNNNNNNNC CGAA AUGGUAUA	5408
7171	UACCAUCUU CAUAUAAU	1253	AUUAUAUG CUGAUGAG GNNNNNNNNC CGAA AGAUGGUA	5409
7172	ACCAUCUUC AUAUAAUA	1254	UAUUAUAU CUGAUGAG GNNNNNNNNC CGAA AAGAUGGU	5410
7175	AUCUUCAUA UAAUAUAC	1255	GUAUAUUA CUGAUGAG GNNNNNNNNC CGAA AUGAAGAU	5411
7177	CUUCAUAUA AUAUACUU	1256	AAGUAUAU CUGAUGAG GNNNNNNNNC CGAA AUAUGAAG	5412
7180	CAUAUAAUA UACUUAAA	1257	UUUAAGUA CUGAUGAG GNNNNNNNNC CGAA AUUAUAUG	5413
7182	UAUAAUAUA CUUAAAAA	1258	UUUUUAAG CUGAUGAG GNNNNNNNNC CGAA AUAUUAUA	5414
7185	AAUAUACUU AAAAAUAU	1259	AUAUUUUU CUGAUGAG GNNNNNNNNC CGAA AGUAUAUU	5415
7186	AUAUACUUA AAAAUAUU	1260	AAUAUUUU CUGAUGAG GNNNNNNNNC CGAA AAGUAUAU	5416
7192	UUAAAAAUA UUUCUUAA	1261	UUAAGAAA CUGAUGAG GNNNNNNNNC CGAA AUUUUUAA	5417
7194	AAAAAUAUU UCUUAAUU	1262	AAUUAAGA CUGAUGAG GNNNNNNNNC CGAA AUAUUUUU	5418
7195	AAAAUAUUU CUUAAUUG	1263	CAAUUAAG CUGAUGAG GNNNNNNNNC CGAA AAUAUUUU	5419
7196	AAAUAUUUC UUAAUUGG	1264	CCAAUUAA CUGAUGAG GNNNNNNNNC CGAA AAAUAUUU	5420
7198	AUAUUUCUU AAUUGGGA	1265	UCCCAAUU CUGAUGAG GNNNNNNNNC CGAA AGAAAUAU	5421
7199	UAUUUCUUA AUUGGGAU	1266	AUCCCAAU CUGAUGAG GNNNNNNNNC CGAA AAGAAAUA	5422
7202	UUCUUAAUU GGGAUUUG	1267	CAAAUCCC CUGAUGAG GNNNNNNNNC CGAA AUUAAGAA	5423
7208	AUUGGGAUU UGUAAUCG	1268	CGAUUACA CUGAUGAG GNNNNNNNNC CGAA AUCCCAAU	5424
7209	UUGGGAUUU GUAAUCGU	1269	ACGAUUAC CUGAUGAG GNNNNNNNNC CGAA AAUCCCAA	5425
7212	GGAUUUGUA AUCGUACC	1270	GGUACGAU CUGAUGAG GNNNNNNNNC CGAA ACAAAUCC	5426
7215	UUUGUAAUC GUACCAAC	1271	GUUGGUAC CUGAUGAG GNNNNNNNNC CGAA AUUACAAA	5427
7218	GUAAUCGUA CCAACUUA	1272	UAAGUUGG CUGAUGAG GNNNNNNNNC CGAA ACGAUUAC	5428
7225	UACCAACUU AAUUGAUA	1273	UAUCAAUU CUGAUGAG GNNNNNNNNC CGAA AGUUGGUA	5429
7226	ACCAACUUA AUUGAUAA	1274	UUAUCAAU CUGAUGAG GNNNNNNNNC CGAA AAGUUGGU	5430
7229	AACUUAAUU GAUAAACU	1275	AGUUUAUC CUGAUGAG GNNNNNNNNC CGAA AUUAAGUU	5431
7233	UAAUUGAUA AACUUGGC	1276	GCCAAGUU CUGAUGAG GNNNNNNNNC CGAA AUCAAUUA	5432
7238	GAUAAACUU GGCAACUG	1277	CAGUUGCC CUGAUGAG GNNNNNNNNC CGAA AGUUUAUC	5433
7249	CAACUGCUU UUAUGUUC	1278	GAACAUAA CUGAUGAG GNNNNNNNNC CGAA AGCAGUUG	5434
7250	AACUGCUUU UAUGUUCU	1279	AGAACAUA CUGAUGAG GNNNNNNNNC CGAA AAGCAGUU	5435
7251	ACUGCUUUU AUGUUCUG	1280	CAGAACAU CUGAUGAG GNNNNNNNNC CGAA AAAGCAGU	5436
7252	CUGCUUUUA UGUUCUGU	1281	ACAGAACA CUGAUGAG GNNNNNNNNC CGAA AAAAGCAG	5437
7256	UUUUAUGUU CUGUCUCC	1282	GGAGACAG CUGAUGAG GNNNNNNNNC CGAA ACAUAAAA	5438
7257	UUUAUGUUC UGUCUCCU	1283	AGGAGACA CUGAUGAG GNNNNNNNNC CGAA AACAUAAA	5439
7261	UGUUCUGUC UCCUUCCA	1284	UGGAAGGA CUGAUGAG GNNNNNNNNC CGAA ACAGAACA	5440
7263	UUCUGUCUC CUUCCAUA	1285	UAUGGAAG CUGAUGAG GNNNNNNNNC CGAA AGACAGAA	5441
7266	UGUCUCCUU CCAUAAAU	1286	AUUUAUGG CUGAUGAG GNNNNNNNNC CGAA AGGAGACA	5442
7267	GUCUCCUUC CAUAAAUU	1287	AAUUUAUG CUGAUGAG GNNNNNNNNC CGAA AAGGAGAC	5443
7271	CCUUCCAUA AAUUUUUC	1288	GAAAAAUU CUGAUGAG GNNNNNNNNC CGAA AUGGAAGG	5444
7275	CCAUAAAUU UUUCAAAA	1289	UUUUGAAA CUGAUGAG GNNNNNNNNC CGAA AUUUAUGG	5445
7276	CAUAAAUUU UUCAAAAU	1290	AUUUUGAA CUGAUGAG GNNNNNNNNC CGAA AAUUUAUG	5446
7277	AUAAAUUUU UCAAAAUA	1291	UAUUUUGA CUGAUGAG GNNNNNNNNC CGAA AAAUUUAU	5447
7278	UAAAUUUUU CAAAAUAC	1292	GUAUUUUG CUGAUGAG GNNNNNNNNC CGAA AAAAUUUA	5448
7279	AAAUUUUUC AAAAUACU	1293	AGUAUUUU CUGAUGAG GNNNNNNNNC CGAA AAAAAUUU	5449
7285	UUCAAAAUA CUAAUUCA	1294	UGAAUUAG CUGAUGAG GNNNNNNNNC CGAA AUUUUGAA	5450
7288	AAAAUACUA AUUCAACA	1295	UGUUGAAU CUGAUGAG GNNNNNNNNC CGAA AGUAUUUU	5451
7291	AUACUAAUU CAACAAAG	1296	CUUUGUUG CUGAUGAG GNNNNNNNNC CGAA AUUAGUAU	5452
7292	UACUAAUUC AACAAAGA	1297	UCUUUGUU CUGAUGAG GNNNNNNNNC CGAA AAUUAGUA	5453
7308	AAAAAGCUC UUUUUUUU	1298	AAAAAAAA CUGAUGAG GNNNNNNNNC CGAA AGCUUUUU	5454
7310	AAAGCUCUU UUUUUUCC	1299	GGAAAAAA CUGAUGAG GNNNNNNNNC CGAA AGAGCUUU	5455
7311	AAGCUCUUU UUUUUCCU	1300	AGGAAAAA CUGAUGAG GNNNNNNNNC CGAA AAGAGCUU	5456
7312	AGCUCUUUU UUUUCCUA	1301	UAGGAAAA CUGAUGAG GNNNNNNNNC CGAA AAAGAGCU	5457
7313	GCUCUUUUU UUUCCUAA	1302	UUAGGAAA CUGAUGAG GNNNNNNNNC CGAA AAAAGAGC	5458
7314	CUCUUUUUU UUCCUAAA	1303	UUUAGGAA CUGAUGAG GNNNNNNNNC CGAA AAAAAGAG	5459
7315	UCUUUUUUU UCCUAAAA	1304	UUUUAGGA CUGAUGAG GNNNNNNNNC CGAA AAAAAAGA	5460
7316	CUUUUUUUU CCUAAAAU	1305	AUUUUAGG CUGAUGAG GNNNNNNNNC CGAA AAAAAAAG	5461
7317	UUUUUUUUC CUAAAAUA	1306	UAUUUUAG CUGAUGAG GNNNNNNNNC CGAA AAAAAAAA	5462
7320	UUUUUCCUA AAAUAAAC	1307	GUUUAUUU CUGAUGAG GNNNNNNNNC CGAA AGGAAAAA	5463
7325	CCUAAAAUA AACUCAAA	1308	UUUGAGUU CUGAUGAG GNNNNNNNNC CGAA AUUUUAGG	5464
7330	AAUAAACUC AAAUUUAU	1309	AUAAAUUU CUGAUGAG GNNNNNNNNC CGAA AGUUUAUU	5465
7335	ACUCAAAUU UAUCCUUG	1310	CAAGGAUA CUGAUGAG GNNNNNNNNC CGAA AUUUGAGU	5466
7336	CUCAAAUUU AUCCUUGU	1311	ACAAGGAU CUGAUGAG GNNNNNNNNC CGAA AAUUUGAG	5467
7337	UCAAAUUUA UCCUUGUU	1312	AACAAGGA CUGAUGAG GNNNNNNNNC CGAA AAAUUUGA	5468
7339	AAAUUUAUC CUUGUUUA	1313	UAAACAAG CUGAUGAG GNNNNNNNNC CGAA AUAAAUUU	5469
7342	UUUAUCCUU GUUUAGAG	1314	CUCUAAAC CUGAUGAG GNNNNNNNNC CGAA AGGAUAAA	5470
7345	AUCCUUGUU UAGAGCAG	1315	CUGCUCUA CUGAUGAG GNNNNNNNNC CGAA ACAAGGAU	5471
7346	UCCUUGUUU AGAGCAGA	1316	UCUGCUCU CUGAUGAG GNNNNNNNNC CGAA AACAAGGA	5472
7347	CCUUGUUUA GAGCAGAG	1317	CUCUGCUC CUGAUGAG GNNNNNNNNC CGAA AAACAAGG	5473
7362	AGAAAAAUU AAGAAAAA	1318	UUUUUCUU CUGAUGAG GNNNNNNNNC CGAA AUUUUUCU	5474
7363	GAAAAAUUA AGAAAAAC	1319	GUUUUUCU CUGAUGAG GNNNNNNNNC CGAA AAUUUUUC	5475
7373	GAAAAACUU UGAAAUGG	1320	CCAUUUCA CUGAUGAG GNNNNNNNNC CGAA AGUUUUUC	5476
7374	AAAAACUUU GAAAUGGU	1321	ACCAUUUC CUGAUGAG GNNNNNNNNC CGAA AAGUUUUU	5477
7383	GAAAUGGUC UCAAAAAA	1322	UUUUUUGA CUGAUGAG GNNNNNNNNC CGAA ACCAUUUC	5478
7385	AAUGGUCUC AAAAAAUU	1323	AAUUUUUU CUGAUGAG GNNNNNNNNC CGAA AGACCAUU	5479
7393	CAAAAAAUU GCUAAAUA	1324	UAUUUAGC CUGAUGAG GNNNNNNNNC CGAA AUUUUUUG	5480
7397	AAAUUGCUA AAUAUUUU	1325	AAAAUAUU CUGAUGAG GNNNNNNNNC CGAA AGCAAUUU	5481
7401	UGCUAAAUA UUUUCAAU	1326	AUUGAAAA CUGAUGAG GNNNNNNNNC CGAA AUUUAGCA	5482
7403	CUAAAUAUU UUCAAUGG	1327	CCAUUGAA CUGAUGAG GNNNNNNNNC CGAA AUAUUUAG	5483
7404	UAAAUAUUU UCAAUGGA	1328	UCCAUUGA CUGAUGAG GNNNNNNNNC CGAA AAUAUUUA	5484
7405	AAAUAUUUU CAAUGGAA	1329	UUCCAUUG CUGAUGAG GNNNNNNNNC CGAA AAAUAUUU	5485
7406	AAUAUUUUC AAUGGAAA	1330	UUUCCAUU CUGAUGAG GNNNNNNNNC CGAA AAAAUAUU	5486
7418	GGAAAACUA AAUGUUAG	1331	CUAACAUU CUGAUGAG GNNNNNNNNC CGAA AGUUUUCC	5487
7424	CUAAAUGUU AGUUUAGC	1332	GCUAAACU CUGAUGAG GNNNNNNNNC CGAA ACAUUUAG	5488
7425	UAAAUGUUA GUUUAGCU	1333	AGCUAAAC CUGAUGAG GNNNNNNNNC CGAA AACAUUUA	5489
7428	AUGUUAGUU UAGCUGAU	1334	AUCAGCUA CUGAUGAG GNNNNNNNNC CGAA ACUAACAU	5490
7429	UGUUAGUUU AGCUGAUU	1335	AAUCAGCU CUGAUGAG GNNNNNNNNC CGAA AACUAACA	5491
7430	GUUAGUUUA GCUGAUUG	1336	CAAUCAGC CUGAUGAG GNNNNNNNNC CGAA AAACUAAC	5492
7437	UAGCUGAUU GUAUGGGG	1337	CCCCAUAC CUGAUGAG GNNNNNNNNC CGAA AUCAGCUA	5493
7440	CUGAUUGUA UGGGGUUU	1338	AAACCCCA CUGAUGAG GNNNNNNNNC CGAA ACAAUCAG	5494
7447	UAUGGGGUU UUCGAACC	1339	GGUUCGAA CUGAUGAG GNNNNNNNNC CGAA ACCCCAUA	5495
7448	AUGGGGUUU UCGAACCU	1340	AGGUUCGA CUGAUGAG GNNNNNNNNC CGAA AACCCCAU	5496
7449	UGGGGUUUU CGAACCUU	1341	AAGGUUCG CUGAUGAG GNNNNNNNNC CGAA AAACCCCA	5497
7450	GGGGUUUUC GAACCUUU	1342	AAAGGUUC CUGAUGAG GNNNNNNNNC CGAA AAAACCCC	5498
7457	UCGAACCUU UCACUUUU	1343	AAAAGUGA CUGAUGAG GNNNNNNNNC CGAA AGGUUCGA	5499
7458	CGAACCUUU CACUUUUU	1344	AAAAAGUG CUGAUGAG GNNNNNNNNC CGAA AAGGUUCG	5500
7459	GAACCUUUC ACUUUUUG	1345	CAAAAAGU CUGAUGAG GNNNNNNNNC CGAA AAAGGUUC	5501
7463	CUUUCACUU UUUGUUUG	1346	CAAACAAA CUGAUGAG GNNNNNNNNC CGAA AGUGAAAG	5502
7464	UUUCACUUU UUGUUUGU	1347	ACAAACAA CUGAUGAG GNNNNNNNNC CGAA AAGUGAAA	5503
7465	UUCACUUUU UGUUUGUU	1348	AACAAACA CUGAUGAG GNNNNNNNNC CGAA AAAGUGAA	5504
7466	UCACUUUUU GUUUGUUU	1349	AAACAAAC CUGAUGAG GNNNNNNNNC CGAA AAAAGUGA	5505
7469	CUUUUUGUU UGUUUUAC	1350	GUAAAACA CUGAUGAG GNNNNNNNNC CGAA ACAAAAAG	5506
7470	UUUUUGUUU GUUUUACC	1351	GGUAAAAC CUGAUGAG GNNNNNNNNC CGAA AACAAAAA	5507
7473	UUGUUUGUU UUACCUAU	1352	AUAGGUAA CUGAUGAG GNNNNNNNNC CGAA ACAAACAA	5508
7474	UGUUUGUUU UACCUAUU	1353	AAUAGGUA CUGAUGAG GNNNNNNNNC CGAA AACAAACA	5509
7475	GUUUGUUUU ACCUAUUU	1354	AAAUAGGU CUGAUGAG GNNNNNNNNC CGAA AAACAAAC	5510
7476	UUUGUUUUA CCUAUUUC	1355	GAAAUAGG CUGAUGAG GNNNNNNNNC CGAA AAAACAAA	5511
7480	UUUUACCUA UUUCACAA	1356	UUGUGAAA CUGAUGAG GNNNNNNNNC CGAA AGGUAAAA	5512
7482	UUACCUAUU UCACAACU	1357	AGUUGUGA CUGAUGAG GNNNNNNNNC CGAA AUAGGUAA	5513
7483	UACCUAUUU CACAACUG	1358	CAGUUGUG CUGAUGAG GNNNNNNNNC CGAA AAUAGGUA	5514
7484	ACCUAUUUC ACAACUGU	1359	ACAGUUGU CUGAUGAG GNNNNNNNNC CGAA AAAUAGGU	5515
7495	AACUGUGUA AAUUGCCA	1360	UGGCAAUU CUGAUGAG GNNNNNNNNC CGAA ACACAGUU	5516
7499	GUGUAAAUU GCCAAUAA	1361	UUAUUGGC CUGAUGAG GNNNNNNNNC CGAA AUUUACAC	5517
7506	UUGCCAAUA AUUCCUGU	1362	ACAGGAAU CUGAUGAG GNNNNNNNNC CGAA AUUGGCAA	5518
7509	CCAAUAAUU CCUGUCCA	1363	UGGACAGG CUGAUGAG GNNNNNNNNC CGAA AUUAUUGG	5519
7510	CAAUAAUUC CUGUCCAU	1364	AUGGACAG CUGAUGAG GNNNNNNNNC CGAA AAUUAUUG	5520
7515	AUUCCUGUC CAUGAAAA	1365	UUUUCAUG CUGAUGAG GNNNNNNNNC CGAA ACAGGAAU	5521
7531	AUGCAAAUU AUCCAGUG	1366	CACUGGAU CUGAUGAG GNNNNNNNNC CGAA AUUUGCAU	5522
7532	UGCAAAUUA UCCAGUGU	1367	ACACUGGA CUGAUGAG GNNNNNNNNC CGAA AAUUUGCA	5523
7534	CAAAUUAUC CAGUGUAG	1368	CUACACUG CUGAUGAG GNNNNNNNNC CGAA AUAAUUUG	5524
7541	UCCAGUGUA GAUAUAUU	1369	AAUAUAUC CUGAUGAG GNNNNNNNNC CGAA ACACUGGA	5525
7545	GUGUAGAUA UAUUUGAC	1370	GUCAAAUA CUGAUGAG GNNNNNNNNC CGAA AUCUACAC	5526
7547	GUAGAUAUA UUUGACCA	1371	UGGUCAAA CUGAUGAG GNNNNNNNNC CGAA AUAUCUAC	5527
7549	AGAUAUAUU UGACCAUC	1372	GAUGGUCA CUGAUGAG GNNNNNNNNC CGAA AUAUAUCU	5528
7550	GAUAUAUUU GACCAUCA	1373	UGAUGGUC CUGAUGAG GNNNNNNNNC CGAA AAUAUAUC	5529
7557	UUGACCAUC ACCCUAUG	1374	CAUAGGGU CUGAUGAG GNNNNNNNNC CGAA AUGGUCAA	5530
7563	AUCACCCUA UGGAUAUU	1375	AAUAUCCA CUGAUGAG GNNNNNNNNC CGAA AGGGUGAU	5531
7569	CUAUGGAUA UUGGCUAG	1376	CUAGCCAA CUGAUGAG GNNNNNNNNC CGAA AUCCAUAG	5532
7571	AUGGAUAUU GGCUAGUU	1377	AACUAGCC CUGAUGAG GNNNNNNNNC CGAA AUAUCCAU	5533
7576	UAUUGGCUA GUUUUGCC	1378	GGCAAAAC CUGAUGAG GNNNNNNNNC CGAA AGCCAAUA	5534
7579	UGGCUAGUU UUGCCUUU	1379	AAAGGCAA CUGAUGAG GNNNNNNNNC CGAA ACUAGCCA	5535
7580	GGCUAGUUU UGCCUUUA	1380	UAAAGGCA CUGAUGAG GNNNNNNNNC CGAA AACUAGCC	5536
7581	GCUAGUUUU GCCUUUAU	1381	AUAAAGGC CUGAUGAG GNNNNNNNNC CGAA AAACUAGC	5537
7586	UUUUGCCUU UAUUAAGC	1382	GCUUAAUA CUGAUGAG GNNNNNNNNC CGAA AGGCAAAA	5538
7587	UUUGCCUUU AUUAAGCA	1383	UGCUUAAU CUGAUGAG GNNNNNNNNC CGAA AAGGCAAA	5539
7588	UUGCCUUUA UUAAGCAA	1384	UUGCUUAA CUGAUGAG GNNNNNNNNC CGAA AAAGGCAA	5540
7590	GCCUUUAUU AAGCAAAU	1385	AUUUGCUU CUGAUGAG GNNNNNNNNC CGAA AUAAAGGC	5541
7591	CCUUUAUUA AGCAAAUU	1386	AAUUUGCU CUGAUGAG GNNNNNNNNC CGAA AAUAAAGG	5542
7599	AAGCAAAUU CAUUUCAG	1387	CUGAAAUG CUGAUGAG GNNNNNNNNC CGAA AUUUGCUU	5543
7600	AGCAAAUUC AUUUCAGC	1388	GCUGAAAU CUGAUGAG GNNNNNNNNC CGAA AAUUUGCU	5544
7603	AAAUUCAUU UCAGCCUG	1389	CAGGCUGA CUGAUGAG GNNNNNNNNC CGAA AUGAAUUU	5545
7604	AAUUCAUUU CAGCCUGA	1390	UCAGGCUG CUGAUGAG GNNNNNNNNC CGAA AAUGAAUU	5546
7605	AUUCAUUUC AGCCUGAA	1391	UUCAGGCU CUGAUGAG GNNNNNNNNC CGAA AAAUGAAU	5547
7617	CUGAAUGUC UGCCUAUA	1392	UAUAGGCA CUGAUGAG GNNNNNNNNC CGAA ACAUUCAG	5548
7623	GUCUGCCUA UAUAUUCU	1393	AGAAUAUA CUGAUGAG GNNNNNNNNC CGAA AGGCAGAC	5549
7625	CUGCCUAUA UAUUCUCU	1394	AGAGAAUA CUGAUGAG GNNNNNNNNC CGAA AUAGGCAG	5550
7627	GCCUAUAUA UUCUCUGC	1395	GCAGAGAA CUGAUGAG GNNNNNNNNC CGAA AUAUAGGC	5551
7629	CUAUAUAUU CUCUGCUC	1396	GAGCAGAG CUGAUGAG GNNNNNNNNC CGAA AUAUAUAG	5552
7630	UAUAUAUUC UCUGCUCU	1397	AGAGCAGA CUGAUGAG GNNNNNNNNC CGAA AAUAUAUA	5553
7632	UAUAUUCUC UGCUCUUU	1398	AAAGAGCA CUGAUGAG GNNNNNNNNC CGAA AGAAUAUA	5554
7637	UCUCUGCUC UUUGUAUU	1399	AAUACAAA CUGAUGAG GNNNNNNNNC CGAA AGCAGAGA	5555
7639	UCUGCUCUU UGUAUUCU	1400	AGAAUACA CUGAUGAG GNNNNNNNNC CGAA AGAGCAGA	5556
7640	CUGCUCUUU GUAUUCUC	1401	GAGAAUAC CUGAUGAG GNNNNNNNNC CGAA AAGAGCAG	5557
7643	CUCUUUGUA UUCUCCUU	1402	AAGGAGAA CUGAUGAG GNNNNNNNNC CGAA ACAAAGAG	5558
7645	CUUUGUAUU CUCCUUUG	1403	CAAAGGAG CUGAUGAG GNNNNNNNNC CGAA AUACAAAG	5559
7646	UUUGUAUUC UCCUUUGA	1404	UCAAAGGA CUGAUGAG GNNNNNNNNC CGAA AAUACAAA	5560
7648	UGUAUUCUC CUUUGAAC	1405	GUUCAAAG CUGAUGAG GNNNNNNNNC CGAA AGAAUACA	5561
7651	AUUCUCCUU UGAACCCG	1406	CGGGUUCA CUGAUGAG GNNNNNNNNC CGAA AGGAGAAU	5562
7652	UUCUCCUUU GAACCCGU	1407	ACGGGUUC CUGAUGAG GNNNNNNNNC CGAA AAGGAGAA	5563
7661	GAACCCGUU AAAACAUC	1408	GAUGUUUU CUGAUGAG GNNNNNNNNC CGAA ACGGGUUC	5564
7662	AACCCGUUA AAACAUCC	1409	GGAUGUUU CUGAUGAG GNNNNNNNNC CGAA AACGGGUU	5565
7669	UAAAACAUC CUGUGGCA	1410	UGCCACAG CUGAUGAG GNNNNNNNNC CGAA AUGUUUUA	5566
Where “X” represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be ≧2 base-pairs.
Underlined region can be any X sequence or linker, as described herein.

TABLE III
Human flt1 VEGF Receptor-Hairpin Ribozyme and Substrate sequence
	Seq		Seq
	ID		ID
Pos Substrate	No	HP Ribozyme Sequence	No
16 CCUCUCG GCU CCUCCCCG	1411	CGGGGAGG AGAA GAGAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5567
39 GGCGGCG GCU CGGAGCGG	1412	CCGCUCCG AGAA GCCGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5568
180 GAGGACG GAC UCUGGCGG	1413	CCGCCAGA AGAA GUCCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5569
190 UCUGGCG GCC GGGUCGUU	1414	AACGACCC AGAA GCCAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5570
278 GGGUCCU GCU GUGCGCGC	1415	GCGCGCAC AGAA GGACCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5571
290 GCGCGCU GCU CAGCUGUC	1416	GACAGCUG AGAA GCGCGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5572
295 CUGCUCA GCU GUCUGCUU	1417	AAGCAGAC AGAA GAGCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5573
298 CUCAGCU GUC UGCUUCUC	1418	GAGAAGCA AGAA GCUGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5574
302 GCUGUCU GCU UCUCACAG	1419	CUGUGAGA AGAA GACAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5575
420 GGAAGCA GCC CAUAAAUG	1420	CAUUUAUG AGAA GCUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5576
486 UAAAUCU GCC UGUGGAAG	1421	CUUCCACA AGAA GAUUUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5577
537 GAACACA GCU CAAGCAAA	1422	UUUGCUUG AGAA GUGUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5578
565 UUCUACA GCU GCAAAUAU	1423	AUAUUUGC AGAA GUAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5579
721 AUUCCCU GCC GGGUUACG	1424	CGUAACCC AGAA GGGAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5580
786 GAUCCCU GAU GGAAAACG	1425	CGUUUUCC AGAA GGGAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5581
863 GGCUUCU GAC CUGUGAAG	1426	CUUCACAG AGAA GAAGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5582
1056 UUACCCU GAU GAAAAAAA	1427	UUUUUUUC AGAA GGGUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5583
1301 GCAAGCG GUC UUACCGGC	1428	GCCGGUAA AGAA GCUUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5584
1310 CUUACCG GCU CUCUAUGA	1429	UCAUAGAG AGAA GGUAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5585
1389 GAAAUCU GCU CGCUAUUU	1430	AAAUAGCG AGAA GAUUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5586
1535 AACCCCA GAU UUACGAAA	1431	UUUCGUAA AGAA GGGGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5587
1566 GUUUCCA GAC CCGGCUCU	1432	AGAGCCGG AGAA GGAAAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5588
1572 AGACCCG GCU CUCUACCC	1433	GGGUAGAG AGAA GGGUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5589
1604 AAAUCCU GAC UUGUACCG	1434	CGGUACAA AGAA GGAUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5590
1824 UGUGGCU GAC UCUAGAAU	1435	AUUCUAGA AGAA GCCACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5591
1908 UAUCACA GAU GUGCCAAA	1436	UUUGGCAC AGAA GUGAUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5592
1949 AAAUGCC GAC GGAAGGAG	1437	CUCCUUCC AGAA GCAUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5593
1973 UGAAACU GUC UUGCACAG	1438	CUGUGCAA AGAA GUUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5594
2275 AUCAGCA GUU CCACCACU	1439	AGUGGUGG AGAA GCUGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5595
2321 AGCCUCA GAU CACUUGGU	1440	ACCAAGUG AGAA GAGGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5596
2396 GCACGCU GUU UAUUGAAA	1441	UUUCAAUA AGAA GCGUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5597
2490 CCUCACU GUU CAAGGAAC	1442	GUUCCUUG AGAA GUGAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5598
2525 UGGAGCU GAU CACUCUAA	1443	UUAGAGUG AGAA GCUCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5599
2625 AAAGACU GAC UACCUAUC	1444	GAUAGGUA AGAA GUCUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5600
2652 GGACCCA GAU GAAGUUCC	1445	GGAACUUC AGAA GGGUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5601
2684 GUGAGCG GCU CCCUUAUG	1446	CAUAAGGG AGAA GCUCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5602
2816 CGUGCCG GAC UGUGGCUG	1447	CAGCCACA AGAA GGCACG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5603
2873 AAGCUCU GAU GACUGAGC	1448	GCUCAGUC AGAA GAGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5604
2930 UUAACCU GCU GGGAGCCU	1449	AGGCUCCC AGAA GGUUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5605
2963 GGCCUCU GAU GGUGAUUG	1450	CAAUCACC AGAA GAGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5606
3157 AGCUCCG GCU UUCAGGAA	1451	UUCCUGAA AGAA GGAGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5607
3207 GGAUUCU GAC GGUUUCUA	1452	UAGAAACC AGAA GAAUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5608
3211 UCUGACG GUU UCUACAAG	1453	CUUGUAGA AGAA GUCAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5609
3245 AAGAUCU GAU UUCUUACA	1454	UGUAAGAA AGAA GAUCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5610
3256 UCUUACA GUU UUCAAGUG	1455	CACUUGAA AGAA GUAAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5611
3287 AGUUCCU GUC UUCCAGAA	1456	UUCUGGAA AGAA GGAACU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5612
3402 GAACCCC GAU UAUGUGAG	1457	CUCACAUA AGAA GGGUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5613
3580 UUUUGCA GUC GCCUGAGG	1458	CCUCAGGC AGAA GCAAAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5614
3641 UCUAUCA GAU CAUGCUGG	1459	CCAGCAUG AGAA GAUAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5615
3655 CUGGACU GCU GGCACAGA	1460	UCUGUGCC AGAA GUCCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5616
3810 AACUCCU GCC UUCUCUGA	1461	UCAGAGAA AGAA GGAGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5617
3846 UAUUUCA GCU CCGAAGUU	1462	AACUUCGG AGAA GAAAUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5618
3873 AAGCUCU GAU GAUGUCAG	1463	CUGACAUC AGAA GAGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5619
3995 GCACUCU GUU GGCCUCUC	1464	GAGAGGCC AGAA GAGUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5620
4100 CGGGGCU GUC UGAUGUCA	1465	UGACAUCA AGAA GCCCCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5621
4104 GCUGUCU GAU GUCAGCAG	1466	CUGCUGAC AGAA GACAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5622
4120 AGGCCCA GUU UCUGCCAU	1467	AUGGCAGA AGAA GGGCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5623
4135 CAUUCCA GCU GUGGGCAC	1468	GUGCCCAC AGAA GGAAUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5624
4210 GCGUGCU GCU CCCCGCCC	1469	GGGCGGGG AGAA GCACGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5625
4217 GCUCCCC GCC CCCAGACU	1470	AGUCUGGG AGAA GGGAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5626
4224 GCCCCCA GAC UACAACUC	1471	GAGUUGUA AGAA GGGGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5627
4382 GGAGCCA GCU GCUUUUUG	1472	CAAAAAGC AGAA GGCUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5628
4385 GCCAGCU GCU UUUUGUGA	1473	UCACAAAA AGAA GCUGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5629
4537 CUUCCCU GCU CCAACCCC	1474	GGGGUUGG AGAA GGGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5630
4573 AGGACCA GUU UGAUUGAG	1475	CUCAAUCA AGAA GGUCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5631
4594 CUGCACU GAU CACCCAAU	1476	AUUGGGUG AGAA GUGCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5632
4628 UGGGCCA GCC CUGCAGCC	1477	GGCUGCAG AGAA GGCCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5633
4636 CCCUGCA GCC CAAAACCC	1478	GGGUUUUG AGAA GCAGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5634
4866 CUUCCCA GCU CUGACCCU	1479	AGGGUCAG AGAA GGGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5635
4871 CAGCUCU GAC CCUUCUAC	1480	GUAGAAGG AGAA GAGCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5636
4905 AGGAGCA GAU GGACAGCG	1481	CGCUGUCC AGAA GCUCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5637
5233 UUAUUCU GUU UUGCACAG	1482	CUGUGCAA AGAA GAAUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5638
5281 AAAUGCA GUC CUGAGGAG	1483	CUCCUCAG AGAA GCAUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5639
5319 GAGGGCU GAU GGAGGAAA	1484	UUUCCUCC AGAA GCCCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5640
5358 AGACCCC GUC UCUAUACC	1485	GGUAUAGA AGAA GGGUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5641
5392 CAACACA GUU GGGACCCA	1486	UGGGUCCC AGAA GUGUUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5642
5563 UUCUCCA GUU GGGACUCA	1487	UGAGUCCC AGAA GGAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5643
5622 UUCAACU GCU UUGAAACU	1488	AGUUUCAA AGAA GUUGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5644
5738 UGGCUCU GUU UGAUGCUA	1489	UAGCAUCA AGAA GAGCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5645
5838 UGGCUCU GUU UGAUGCUA	1489	UAGCAUCA AGAA GAGCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5645
5933 GAUUGCU GCU UCUUGGGG	1490	CCCCAAGA AGAA GCAAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5646
6022 UGCCUCU GUU CUUAUGUG	1491	CACAUAAG AGAA GAGGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5647
6120 GGCAGCG GCU UUUGUGGA	1492	UCCACAAA AGAA GCUGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5648
6163 UGGGACA GUC CUCUCCAC	1493	GUGGAGAG AGAA GUCCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5649
6270 UGUGACA GCU GGCAAUUU	1494	AAAUUGCC AGAA GUCACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5650
6412 CUUAGCU GUU CAUGUCUU	1495	AAGACAUG AGAA GCUAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5651
6511 UUACUCA GCU CCUUCAAA	1496	UUUGAAGG AGAA GAGUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5652
6778 UGGAACA GUC UGGGUGGA	1497	UCCACCCA AGAA GUUCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5653
6826 CUUGUCA GUC CAAGAAGU	1498	ACUUCUUG AGAA GACAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5654
7245 GGCAACU GCU UUUAUGUU	1499	AACAUAAA AGAA GUUGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5655
7258 AUGUUCU GUC UCCUUCCA	1500	UGGAAGGA AGAA GAACAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5656
7433 UUUAGCU GAU UGUAUGGG	1501	CCCAUACA AGAA GCUAAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5657
7512 AAUUCCU GUC CAUGAAAA	1502	UUUUCAUG AGAA GGAAUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5658
7606 CAUUUCA GCC UGAAUGUC	1503	GACAUUCA AGAA GAAAUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5659
7618 AAUGUCU GCC UAUAUAUU	1504	AAUAUAUA AGAA GACAUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5660
7633 AUUCUCU GCU CUUUGUAU	1505	AUACAAAG AGAA GAGAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5661

TABLE IV
Human KDR VEGF Receptor-Hammerhead Ribozyme and Substrate
Sequence
		Seq ID		Seq ID
Pos	Substrate	No	HH Ribozyme Sequence	No
21	CUGGCCGUC GCCCUGUG	1506	CACAGGGC CUGAUGAG GNNNNNNNNC CGAA ACGGCCAG	5662
33	CUGUGGCUC UGCGUGGA	1507	UCCACGCA CUGAUGAG GNNNNNNNNC CGAA AGCCACAG	5663
56	GGCCGCCUC UGUGGGUU	1508	AACCCACA CUGAUGAG GNNNNNNNNC CGAA AGGCGGCC	5664
64	CUGUGGGUU UGCCUAGU	1509	ACUAGGCA CUGAUGAG GNNNNNNNNC CGAA ACCCACAG	5665
65	UGUGGGUUU GCCUAGUG	1510	CACUAGGC CUGAUGAG GNNNNNNNNC CGAA AACCCACA	5666
70	GUUUGCCUA GUGUUUCU	1511	AGAAACAC CUGAUGAG GNNNNNNNNC CGAA AGGCAAAC	5667
75	CCUAGUGUU UCUCUUGA	1512	UCAAGAGA CUGAUGAG GNNNNNNNNC CGAA ACACUAGG	5668
76	CUAGUGUUU CUCUUGAU	1513	AUCAAGAG CUGAUGAG GNNNNNNNNC CGAA AACACUAG	5669
77	UAGUGUUUC UCUUGAUC	1514	GAUCAAGA CUGAUGAG GNNNNNNNNC CGAA AAACACUA	5670
79	GUGUUUCUC UUGAUCUG	1515	CAGAUCAA CUGAUGAG GNNNNNNNNC CGAA AGAAACAC	5671
81	GUUUCUCUU GAUCUGCC	1516	GGCAGAUC CUGAUGAG GNNNNNNNNC CGAA AGAGAAAC	5672
85	CUCUUGAUC UGCCCAGG	1517	CCUGGGCA CUGAUGAG GNNNNNNNNC CGAA AUCAAGAG	5673
96	CCCAGGCUC AGCAUACA	1518	UGUAUGCU CUGAUGAG GNNNNNNNNC CGAA AGCCUGGG	5674
102	CUCAGCAUA CAAAAAGA	1519	UCUUUUUG CUGAUGAG GNNNNNNNNC CGAA AUGCUGAG	5675
114	AAAGACAUA CUUACAAU	1520	AUUGUAAG CUGAUGAG GNNNNNNNNC CGAA AUGUCUUU	5676
117	GACAUACUU ACAAUUAA	1521	UUAAUUGU CUGAUGAG GNNNNNNNNC CGAA AGUAUGUC	5677
118	ACAUACUUA CAAUUAAG	1522	CUUAAUUG CUGAUGAG GNNNNNNNNC CGAA AAGUAUGU	5678
123	CUUACAAUU AAGGCUAA	1523	UUAGCCUU CUGAUGAG GNNNNNNNNC CGAA AUUGUAAG	5679
124	UUACAAUUA AGGCUAAU	1524	AUUAGCCU CUGAUGAG GNNNNNNNNC CGAA AAUUGUAA	5680
130	UUAAGGCUA AUACAACU	1525	AGUUGUAU CUGAUGAG GNNNNNNNNC CGAA AGCCUUAA	5681
133	AGGCUAAUA CAACUCUU	1526	AAGAGUUG CUGAUGAG GNNNNNNNNC CGAA AUUAGCCU	5682
139	AUACAACUC UUCAAAUU	1527	AAUUUGAA CUGAUGAG GNNNNNNNNC CGAA AGUUGUAU	5683
141	ACAACUCUU CAAAUUAC	1528	GUAAUUUG CUGAUGAG GNNNNNNNNC CGAA AGAGUUGU	5684
142	CAACUCUUC AAAUUACU	1529	AGUAAUUU CUGAUGAG GNNNNNNNNC CGAA AAGAGUUG	5685
147	CUUCAAAUU ACUUGCAG	1530	CUGCAAGU CUGAUGAG GNNNNNNNNC CGAA AUUUGAAG	5686
148	UUCAAAUUA CUUGCAGG	1531	CCUGCAAG CUGAUGAG GNNNNNNNNC CGAA AAUUUGAA	5687
151	AAAUUACUU GCAGGGGA	1532	UCCCCUGC CUGAUGAG GNNNNNNNNC CGAA AGUAAUUU	5688
170	GAGGGACUU GGACUGGC	1533	GCCAGUCC CUGAUGAG GNNNNNNNNC CGAA AGUCCCUC	5689
180	GACUGGCUU UGGCCCAA	1534	UUGGGCCA CUGAUGAG GNNNNNNNNC CGAA AGCCAGUC	5690
181	ACUGGCUUU GGCCCAAU	1535	AUUGGGCC CUGAUGAG GNNNNNNNNC CGAA AAGCCAGU	5691
190	GGCCCAAUA AUCAGAGU	1536	ACUCUGAU CUGAUGAG GNNNNNNNNC CGAA AUUGGGCC	5692
193	CCAAUAAUC AGAGUGGC	1537	GCCACUCU CUGAUGAG GNNNNNNNNC CGAA AUUAUUGG	5693
243	GAUGGCCUC UUCUGUAA	1538	UUACAGAA CUGAUGAG GNNNNNNNNC CGAA AGGCCAUC	5694
245	UGGCCUCUU CUGUAAGA	1539	UCUUACAG CUGAUGAG GNNNNNNNNC CGAA AGAGGCCA	5695
246	GGCCUCUUC UGUAAGAC	1540	GUCUUACA CUGAUGAG GNNNNNNNNC CGAA AAGAGGCC	5696
250	UCUUCUGUA AGACACUC	1541	GAGUGUCU CUGAUGAG GNNNNNNNNC CGAA ACAGAAGA	5697
258	AAGACACUC ACAAUUCC	1542	GGAAUUGU CUGAUGAG GNNNNNNNNC CGAA AGUGUCUU	5698
264	CUCACAAUU CCAAAAGU	1543	ACUUUUGG CUGAUGAG GNNNNNNNNC CGAA AUUGUGAG	5699
265	UCACAAUUC CAAAAGUG	1544	CACUUUUG CUGAUGAG GNNNNNNNNC CGAA AAUUGUGA	5700
276	AAAGUGAUC GGAAAUGA	1545	UCAUUUCC CUGAUGAG GNNNNNNNNC CGAA AUCACUUU	5701
296	UGGAGCCUA CAAGUGCU	1546	AGCACUUG CUGAUGAG GNNNNNNNNC CGAA AGGCUCCA	5702
305	CAAGUGCUU CUACCGGG	1547	CCCGGUAG CUGAUGAG GNNNNNNNNC CGAA AGCACUUG	5703
306	AAGUGCUUC UACCGGGA	1548	UCCCGGUA CUGAUGAG GNNNNNNNNC CGAA AAGCACUU	5704
308	GUGCUUCUA CCGGGAAA	1549	UUUCCCGG CUGAUGAG GNNNNNNNNC CGAA AGAAGCAC	5705
323	AACUGACUU GGCCUCGG	1550	CCGAGGCC CUGAUGAG GNNNNNNNNC CGAA AGUCAGUU	5706
329	CUUGGCCUC GGUCAUUU	1551	AAAUGACC CUGAUGAG GNNNNNNNNC CGAA AGGCCAAG	5707
333	GCCUCGGUC AUUUAUGU	1552	ACAUAAAU CUGAUGAG GNNNNNNNNC CGAA ACCGAGGC	5708
336	UCGGUCAUU UAUGUCUA	1553	UAGACAUA CUGAUGAG GNNNNNNNNC CGAA AUGACCGA	5709
337	CGGUCAUUU AUGUCUAU	1554	AUAGACAU CUGAUGAG GNNNNNNNNC CGAA AAUGACCG	5710
338	GGUCAUUUA UGUCUAUG	1555	CAUAGACA CUGAUGAG GNNNNNNNNC CGAA AAAUGACC	5711
342	AUUUAUGUC UAUGUUCA	1556	UGAACAUA CUGAUGAG GNNNNNNNNC CGAA ACAUAAAU	5712
344	UUAUGUCUA UGUUCAAG	1557	CUUGAACA CUGAUGAG GNNNNNNNNC CGAA AGACAUAA	5713
348	GUCUAUGUU CAAGAUUA	1558	UAAUCUUG CUGAUGAG GNNNNNNNNC CGAA ACAUAGAC	5714
349	UCUAUGUUC AAGAUUAC	1559	GUAAUCUU CUGAUGAG GNNNNNNNNC CGAA AACAUAGA	5715
355	UUCAAGAUU ACAGAUCU	1560	AGAUCUGU CUGAUGAG GNNNNNNNNC CGAA AUCUUGAA	5716
356	UCAAGAUUA CAGAUCUC	1561	GAGAUCUG CUGAUGAG GNNNNNNNNC CGAA AAUCUUGA	5717
362	UUACAGAUC UCCAUUUA	1562	UAAAUGGA CUGAUGAG GNNNNNNNNC CGAA AUCUGUAA	5718
364	ACAGAUCUC CAUUUAUU	1563	AAUAAAUG CUGAUGAG GNNNNNNNNC CGAA AGAUCUGU	5719
368	AUCUCCAUU UAUUGCUU	1564	AAGCAAUA CUGAUGAG GNNNNNNNNC CGAA AUGGAGAU	5720
369	UCUCCAUUU AUUGCUUC	1565	GAAGCAAU CUGAUGAG GNNNNNNNNC CGAA AAUGGAGA	5721
370	CUCCAUUUA UUGCUUCU	1566	AGAAGCAA CUGAUGAG GNNNNNNNNC CGAA AAAUGGAG	5722
372	CCAUUUAUU GCUUCUGU	1567	ACAGAAGC CUGAUGAG GNNNNNNNNC CGAA AUAAAUGG	5723
376	UUAUUGCUU CUGUUAGU	1568	ACUAACAG CUGAUGAG GNNNNNNNNC CGAA AGCAAUAA	5724
377	UAUUGCUUC UGUUAGUG	1569	CACUAACA CUGAUGAG GNNNNNNNNC CGAA AAGCAAUA	5725
381	GCUUCUGUU AGUGACCA	1570	UGGUCACU CUGAUGAG GNNNNNNNNC CGAA ACAGAAGC	5726
382	CUUCUGUUA GUGACCAA	1571	UUGGUCAC CUGAUGAG GNNNNNNNNC CGAA AACAGAAG	5727
399	CAUGGAGUC GUGUACAU	1572	AUGUACAC CUGAUGAG GNNNNNNNNC CGAA ACUCCAUG	5728
404	AGUCGUGUA CAUUACUG	1573	CAGUAAUG CUGAUGAG GNNNNNNNNC CGAA ACACGACU	5729
408	GUGUACAUU ACUGAGAA	1574	UUCUCAGU CUGAUGAG GNNNNNNNNC CGAA AUGUACAC	5730
409	UGUACAUUA CUGAGAAC	1575	GUUCUCAG CUGAUGAG GNNNNNNNNC CGAA AAUGUACA	5731
438	GUGGUGAUU CCAUGUCU	1576	AGACAUGG CUGAUGAG GNNNNNNNNC CGAA AUCACCAC	5732
439	UGGUGAUUC CAUGUCUC	1577	GAGACAUG CUGAUGAG GNNNNNNNNC CGAA AAUCACCA	5733
445	UUCCAUGUC UCGGGUCC	1578	GGACCCGA CUGAUGAG GNNNNNNNNC CGAA ACAUGGAA	5734
447	CCAUGUCUC GGGUCCAU	1579	AUGGACCC CUGAUGAG GNNNNNNNNC CGAA AGACAUGG	5735
452	UCUCGGGUC CAUUUCAA	1580	UUGAAAUG CUGAUGAG GNNNNNNNNC CGAA ACCCGAGA	5736
456	GGGUCCAUU UCAAAUCU	1581	AGAUUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGACCC	5737
457	GGUCCAUUU CAAAUCUC	1582	GAGAUUUG CUGAUGAG GNNNNNNNNC CGAA AAUGGACC	5738
458	GUCCAUUUC AAAUCUCA	1583	UGAGAUUU CUGAUGAG GNNNNNNNNC CGAA AAAUGGAC	5739
463	UUUCAAAUC UCAACGUG	1584	CACGUUGA CUGAUGAG GNNNNNNNNC CGAA AUUUGAAA	5740
465	UCAAAUCUC AACGUGUC	1585	GACACGUU CUGAUGAG GNNNNNNNNC CGAA AGAUUUGA	5741
473	CAACGUGUC ACUUUGUG	1586	CACAAAGU CUGAUGAG GNNNNNNNNC CGAA ACACGUUG	5742
477	GUGUCACUU UGUGCAAG	1587	CUUGCACA CUGAUGAG GNNNNNNNNC CGAA AGUGACAC	5743
478	UGUCACUUU GUGCAAGA	1588	UCUUGCAC CUGAUGAG GNNNNNNNNC CGAA AAGUGACA	5744
488	UGCAAGAUA CCCAGAAA	1589	UUUCUGGG CUGAUGAG GNNNNNNNNC CGAA AUCUUGCA	5745
503	AAAGAGAUU UGUUCCUG	1590	CAGGAACA CUGAUGAG GNNNNNNNNC CGAA AUCUCUUU	5746
504	AAGAGAUUU GUUCCUGA	1591	UCAGGAAC CUGAUGAG GNNNNNNNNC CGAA AAUCUCUU	5747
507	AGAUUUGUU CCUGAUGG	1592	CCAUCAGG CUGAUGAG GNNNNNNNNC CGAA ACAAAUCU	5748
508	GAUUUGUUC CUGAUGGU	1593	ACCAUCAG CUGAUGAG GNNNNNNNNC CGAA AACAAAUC	5749
517	CUGAUGGUA ACAGAAUU	1594	AAUUCUGU CUGAUGAG GNNNNNNNNC CGAA ACCAUCAG	5750
525	AACAGAAUU UCCUGGGA	1595	UCCCAGGA CUGAUGAG GNNNNNNNNC CGAA AUUCUGUU	5751
526	ACAGAAUUU CCUGGGAC	1596	GUCCCAGG CUGAUGAG GNNNNNNNNC CGAA AAUUCUGU	5752
527	CAGAAUUUC CUGGGACA	1597	UGUCCCAG CUGAUGAG GNNNNNNNNC CGAA AAAUUCUG	5753
548	GAAGGGCUU UACUAUUC	1598	GAAUAGUA CUGAUGAG GNNNNNNNNC CGAA AGCCCUUC	5754
549	AAGGGCUUU ACUAUUCC	1599	GGAAUAGU CUGAUGAG GNNNNNNNNC CGAA AAGCCCUU	5755
550	AGGGCUUUA CUAUUCCC	1600	GGGAAUAG CUGAUGAG GNNNNNNNNC CGAA AAAGCCCU	5756
553	GCUUUACUA UUCCCAGC	1601	GCUGGGAA CUGAUGAG GNNNNNNNNC CGAA AGUAAAGC	5757
555	UUUACUAUU CCCAGCUA	1602	UAGCUGGG CUGAUGAG GNNNNNNNNC CGAA AUAGUAAA	5758
556	UUACUAUUC CCAGCUAC	1603	GUAGCUGG CUGAUGAG GNNNNNNNNC CGAA AAUAGUAA	5759
563	UCCCAGCUA CAUGAUCA	1604	UGAUCAUG CUGAUGAG GNNNNNNNNC CGAA AGCUGGGA	5760
570	UACAUGAUC AGCUAUGC	1605	GCAUAGCU CUGAUGAG GNNNNNNNNC CGAA AUCAUGUA	5761
575	GAUCAGCUA UGCUGGCA	1606	UGCCAGCA CUGAUGAG GNNNNNNNNC CGAA AGCUGAUC	5762
588	GGCAUGGUC UUCUGUGA	1607	UCACAGAA CUGAUGAG GNNNNNNNNC CGAA ACCAUGCC	5763
590	CAUGGUCUU CUGUGAAG	1608	CUUCACAG CUGAUGAG GNNNNNNNNC CGAA AGACCAUG	5764
591	AUGGUCUUC UGUGAAGC	1609	GCUUCACA CUGAUGAG GNNNNNNNNC CGAA AAGACCAU	5765
606	GCAAAAAUU AAUGAUGA	1610	UCAUCAUU CUGAUGAG GNNNNNNNNC CGAA AUUUUUGC	5766
607	CAAAAAUUA AUGAUGAA	1611	UUCAUCAU CUGAUGAG GNNNNNNNNC CGAA AAUUUUUG	5767
619	AUGAAAGUU ACCAGUCU	1612	AGACUGGU CUGAUGAG GNNNNNNNNC CGAA ACUUUCAU	5768
620	UGAAAGUUA CCAGUCUA	1613	UAGACUGG CUGAUGAG GNNNNNNNNC CGAA AACUUUCA	5769
626	UUACCAGUC UAUUAUGU	1614	ACAUAAUA CUGAUGAG GNNNNNNNNC CGAA ACUGGUAA	5770
628	ACCAGUCUA UUAUGUAC	1615	GUACAUAA CUGAUGAG GNNNNNNNNC CGAA AGACUGGU	5771
630	CAGUCUAUU AUGUACAU	1616	AUGUACAU CUGAUGAG GNNNNNNNNC CGAA AUAGACUG	5772
631	AGUCUAUUA UGUACAUA	1617	UAUGUACA CUGAUGAG GNNNNNNNNC CGAA AAUAGACU	5773
635	UAUUAUGUA CAUAGUUG	1618	CAACUAUG CUGAUGAG GNNNNNNNNC CGAA ACAUAAUA	5774
639	AUGUACAUA GUUGUCGU	1619	ACGACAAC CUGAUGAG GNNNNNNNNC CGAA AUGUACAU	5775
642	UACAUAGUU GUCGUUGU	1620	ACAACGAC CUGAUGAG GNNNNNNNNC CGAA ACUAUGUA	5776
645	AUAGUUGUC GUUGUAGG	1621	CCUACAAC CUGAUGAG GNNNNNNNNC CGAA ACAACUAU	5777
648	GUUGUCGUU GUAGGGUA	1622	UACCCUAC CUGAUGAG GNNNNNNNNC CGAA ACGACAAC	5778
651	GUCGUUGUA GGGUAUAG	1623	CUAUACCC CUGAUGAG GNNNNNNNNC CGAA ACAACGAC	5779
656	UGUAGGGUA UAGGAUUU	1624	AAAUCCUA CUGAUGAG GNNNNNNNNC CGAA ACCCUACA	5780
658	UAGGGUAUA GGAUUUAU	1625	AUAAAUCC CUGAUGAG GNNNNNNNNC CGAA AUACCCUA	5781
663	UAUAGGAUU UAUGAUGU	1626	ACAUCAUA CUGAUGAG GNNNNNNNNC CGAA AUCCUAUA	5782
664	AUAGGAUUU AUGAUGUG	1627	CACAUCAU CUGAUGAG GNNNNNNNNC CGAA AAUCCUAU	5783
665	UAGGAUUUA UGAUGUGG	1628	CCACAUCA CUGAUGAG GNNNNNNNNC CGAA AAAUCCUA	5784
675	GAUGUGGUU CUGAGUCC	1629	GGACUCAG CUGAUGAG GNNNNNNNNC CGAA ACCACAUC	5785
676	AUGUGGUUC UGAGUCCG	1630	CGGACUCA CUGAUGAG GNNNNNNNNC CGAA AACCACAU	5786
682	UUCUGAGUC CGUCUCAU	1631	AUGAGACG CUGAUGAG GNNNNNNNNC CGAA ACUCAGAA	5787
686	GAGUCCGUC UCAUGGAA	1632	UUCCAUGA CUGAUGAG GNNNNNNNNC CGAA ACGGACUC	5788
688	GUCCGUCUC AUGGAAUU	1633	AAUUCCAU CUGAUGAG GNNNNNNNNC CGAA AGACGGAC	5789
696	CAUGGAAUU GAACUAUC	1634	GAUAGUUC CUGAUGAG GNNNNNNNNC CGAA AUUCCAUG	5790
702	AUUGAACUA UCUGUUGG	1635	CCAACAGA CUGAUGAG GNNNNNNNNC CGAA AGUUCAAU	5791
704	UGAACUAUC UGUUGGAG	1636	CUCCAACA CUGAUGAG GNNNNNNNNC CGAA AUAGUUCA	5792
708	CUAUCUGUU GGAGAAAA	1637	UUUUCUCC CUGAUGAG GNNNNNNNNC CGAA ACAGAUAG	5793
720	GAAAAGCUU GUCUUAAA	1638	UUUAAGAC CUGAUGAG GNNNNNNNNC CGAA AGCUUUUC	5794
723	AAGCUUGUC UUAAAUUG	1639	CAAUUUAA CUGAUGAG GNNNNNNNNC CGAA ACAAGCUU	5795
725	GCUUGUCUU AAAUUGUA	1640	UACAAUUU CUGAUGAG GNNNNNNNNC CGAA AGACAAGC	5796
726	CUUGUCUUA AAUUGUAC	1641	GUACAAUU CUGAUGAG GNNNNNNNNC CGAA AAGACAAG	5797
730	UCUUAAAUU GUACAGCA	1642	UGCUGUAC CUGAUGAG GNNNNNNNNC CGAA AUUUAAGA	5798
733	UAAAUUGUA CAGCAAGA	1643	UCUUGCUG CUGAUGAG GNNNNNNNNC CGAA ACAAUUUA	5799
750	ACUGAACUA AAUGUGGG	1644	CCCACAUU CUGAUGAG GNNNNNNNNC CGAA AGUUCAGU	5800
762	GUGGGGAUU GACUUCAA	1645	UUGAAGUC CUGAUGAG GNNNNNNNNC CGAA AUCCCCAC	5801
767	GAUUGACUU CAACUGGG	1646	CCCAGUUG CUGAUGAG GNNNNNNNNC CGAA AGUCAAUC	5802
768	AUUGACUUC AACUGGGA	1647	UCCCAGUU CUGAUGAG GNNNNNNNNC CGAA AAGUCAAU	5803
779	CUGGGAAUA CCCUUCUU	1648	AAGAAGGG CUGAUGAG GNNNNNNNNC CGAA AUUCCCAG	5804
784	AAUACCCUU CUUCGAAG	1649	CUUCGAAG CUGAUGAG GNNNNNNNNC CGAA AGGGUAUU	5805
785	AUACCCUUC UUCGAAGC	1650	GCUUCGAA CUGAUGAG GNNNNNNNNC CGAA AAGGGUAU	5806
787	ACCCUUCUU CGAAGCAU	1651	AUGCUUCG CUGAUGAG GNNNNNNNNC CGAA AGAAGGGU	5807
788	CCCUUCUUC GAAGCAUC	1652	GAUGCUUC CUGAUGAG GNNNNNNNNC CGAA AAGAAGGG	5808
796	CGAAGCAUC AGCAUAAG	1653	CUUAUGCU CUGAUGAG GNNNNNNNNC CGAA AUGCUUCG	5809
802	AUCAGCAUA AGAAACUU	1654	AAGUUUCU CUGAUGAG GNNNNNNNNC CGAA AUGCUGAU	5810
810	AAGAAACUU GUAAACCG	1655	CGGUUUAC CUGAUGAG GNNNNNNNNC CGAA AGUUUCUU	5811
813	AAACUUGUA AACCGAGA	1656	UCUCGGUU CUGAUGAG GNNNNNNNNC CGAA ACAAGUUU	5812
825	CGAGACCUA AAAACCCA	1657	UGGGUUUU CUGAUGAG GNNNNNNNNC CGAA AGGUCUCG	5813
836	AACCCAGUC UGGGAGUG	1658	CACUCCCA CUGAUGAG GNNNNNNNNC CGAA ACUGGGUU	5814
857	GAAGAAAUU UUUGAGCA	1659	UGCUCAAA CUGAUGAG GNNNNNNNNC CGAA AUUUCUUC	5815
858	AAGAAAUUU UUGAGCAC	1660	GUGCUCAA CUGAUGAG GNNNNNNNNC CGAA AAUUUCUU	5816
859	AGAAAUUUU UGAGCACC	1661	GGUGCUCA CUGAUGAG GNNNNNNNNC CGAA AAAUUUCU	5817
860	GAAAUUUUU GAGCACCU	1662	AGGUGCUC CUGAUGAG GNNNNNNNNC CGAA AAAAUUUC	5818
869	GAGCACCUU AACUAUAG	1663	CUAUAGUU CUGAUGAG GNNNNNNNNC CGAA AGGUGCUC	5819
870	AGCACCUUA ACUAUAGA	1664	UCUAUAGU CUGAUGAG GNNNNNNNNC CGAA AAGGUGCU	5820
874	CCUUAACUA UAGAUGGU	1665	ACCAUCUA CUGAUGAG GNNNNNNNNC CGAA AGUUAAGG	5821
876	UUAACUAUA GAUGGUGU	1666	ACACCAUC CUGAUGAG GNNNNNNNNC CGAA AUAGUUAA	5822
885	GAUGGUGUA ACCCGGAG	1667	CUCCGGGU CUGAUGAG GNNNNNNNNC CGAA ACACCAUC	5823
905	CCAAGGAUU GUACACCU	1668	AGGUGUAC CUGAUGAG GNNNNNNNNC CGAA AUCCUUGG	5824
908	AGGAUUGUA CACCUGUG	1669	CACAGGUG CUGAUGAG GNNNNNNNNC CGAA ACAAUCCU	5825
923	UGCAGCAUC CAGUGGGC	1670	GCCCACUG CUGAUGAG GNNNNNNNNC CGAA AUGCUGCA	5826
956	CAGCACAUU UGUCAGGG	1671	CCCUGACA CUGAUGAG GNNNNNNNNC CGAA AUGUGCUG	5827
957	AGCACAUUU GUCAGGGU	1672	ACCCUGAC CUGAUGAG GNNNNNNNNC CGAA AAUGUGCU	5828
960	ACAUUUGUC AGGGUCCA	1673	UGGACCCU CUGAUGAG GNNNNNNNNC CGAA ACAAAUGU	5829
966	GUCAGGGUC CAUGAAAA	1674	UUUUCAUG CUGAUGAG GNNNNNNNNC CGAA ACCCUGAC	5830
979	AAAAACCUU UUGUUGCU	1675	AGCAACAA CUGAUGAG GNNNNNNNNC CGAA AGGUUUUU	5831
980	AAAACCUUU UGUUGCUU	1676	AAGCAACA CUGAUGAG GNNNNNNNNC CGAA AAGGUUUU	5832
981	AAACCUUUU GUUGCUUU	1677	AAAGCAAC CUGAUGAG GNNNNNNNNC CGAA AAAGGUUU	5833
984	CCUUUUGUU GCUUUUGG	1678	CCAAAAGC CUGAUGAG GNNNNNNNNC CGAA ACAAAAGG	5834
988	UUGUUGCUU UUGGAAGU	1679	ACUUCCAA CUGAUGAG GNNNNNNNNC CGAA AGCAACAA	5835
989	UGUUGCUUU UGGAAGUG	1680	CACUUCCA CUGAUGAG GNNNNNNNNC CGAA AAGCAACA	5836
990	GUUGCUUUU GGAAGUGG	1681	CCACUUCC CUGAUGAG GNNNNNNNNC CGAA AAAGCAAC	5837
1007	CAUGGAAUC UCUGGUGG	1682	CCACCAGA CUGAUGAG GNNNNNNNNC CGAA AUUCCAUG	5838
1009	UGGAAUCUC UGGUGGAA	1683	UUCCACCA CUGAUGAG GNNNNNNNNC CGAA AGAUUCCA	5839
1038	GAGCGUGUC AGAAUCCC	1684	GGGAUUCU CUGAUGAG GNNNNNNNNC CGAA ACACGCUC	5840
1044	GUCAGAAUC CCUGCGAA	1685	UUCGCAGG CUGAUGAG GNNNNNNNNC CGAA AUUCUGAC	5841
1055	UGCGAAGUA CCUUGGUU	1686	AACCAAGG CUGAUGAG GNNNNNNNNC CGAA ACUUCGCA	5842
1059	AAGUACCUU GGUUACCC	1687	GGGUAACC CUGAUGAG GNNNNNNNNC CGAA AGGUACUU	5843
1063	ACCUUGGUU ACCCACCC	1688	GGGUGGGU CUGAUGAG GNNNNNNNNC CGAA ACCAAGGU	5844
1064	CCUUGGUUA CCCACCCC	1689	GGGGUGGG CUGAUGAG GNNNNNNNNC CGAA AACCAAGG	5845
1080	CCAGAAAUA AAAUGGUA	1690	UACCAUUU CUGAUGAG GNNNNNNNNC CGAA AUUUCUGG	5846
1088	AAAAUGGUA UAAAAAUG	1691	CAUUUUUA CUGAUGAG GNNNNNNNNC CGAA ACCAUUUU	5847
1090	AAUGGUAUA AAAAUGGA	1692	UCCAUUUU CUGAUGAG GNNNNNNNNC CGAA AUACCAUU	5848
1101	AAUGGAAUA CCCCUUGA	1693	UCAAGGGG CUGAUGAG GNNNNNNNNC CGAA AUUCCAUU	5849
1107	AUACCCCUU GAGUCCAA	1694	UUGGACUC CUGAUGAG GNNNNNNNNC CGAA AGGGGUAU	5850
1112	CCUUGAGUC CAAUCACA	1695	UGUGAUUG CUGAUGAG GNNNNNNNNC CGAA ACUCAAGG	5851
1117	AGUCCAAUC ACACAAUU	1696	AAUUGUGU CUGAUGAG GNNNNNNNNC CGAA AUUGGACU	5852
1125	CACACAAUU AAAGCGGG	1697	CCCGCUUU CUGAUGAG GNNNNNNNNC CGAA AUUGUGUG	5853
1126	ACACAAUUA AAGCGGGG	1698	CCCCGCUU CUGAUGAG GNNNNNNNNC CGAA AAUUGUGU	5854
1140	GGGCAUGUA CUGACGAU	1699	AUCGUCAG CUGAUGAG GNNNNNNNNC CGAA ACAUGCCC	5855
1149	CUGACGAUU AUGGAAGU	1700	ACUUCCAU CUGAUGAG GNNNNNNNNC CGAA AUCGUCAG	5856
1150	UGACGAUUA UGGAAGUG	1701	CACUUCCA CUGAUGAG GNNNNNNNNC CGAA AAUCGUCA	5857
1180	CAGGAAAUU ACACUGUC	1702	GACAGUGU CUGAUGAG GNNNNNNNNC CGAA AUUUCCUG	5858
1181	AGGAAAUUA CACUGUCA	1703	UGACAGUG CUGAUGAG GNNNNNNNNC CGAA AAUUUCCU	5859
1188	UACACUGUC AUCCUUAC	1704	GUAAGGAU CUGAUGAG GNNNNNNNNC CGAA ACAGUGUA	5860
1191	ACUGUCAUC CUUACCAA	1705	UUGGUAAG CUGAUGAG GNNNNNNNNC CGAA AUGACAGU	5861
1194	GUCAUCCUU ACCAAUCC	1706	GGAUUGGU CUGAUGAG GNNNNNNNNC CGAA AGGAUGAC	5862
1195	UCAUCCUUA CCAAUCCC	1707	GGGAUUGG CUGAUGAG GNNNNNNNNC CGAA AAGGAUGA	5863
1201	UUACCAAUC CCAUUUCA	1708	UGAAAUGG CUGAUGAG GNNNNNNNNC CGAA AUUGGUAA	5864
1206	AAUCCCAUU UCAAAGGA	1709	UCCUUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGGAUU	5865
1207	AUCCCAUUU CAAAGGAG	1710	CUCCUUUG CUGAUGAG GNNNNNNNNC CGAA AAUGGGAU	5866
1208	UCCCAUUUC AAAGGAGA	1711	UCUCCUUU CUGAUGAG GNNNNNNNNC CGAA AAAUGGGA	5867
1233	CAUGUGGUC UCUCUGGU	1712	ACCAGAGA CUGAUGAG GNNNNNNNNC CGAA ACCACAUG	5868
1235	UGUGGUCUC UCUGGUUG	1713	CAACCAGA CUGAUGAG GNNNNNNNNC CGAA AGACCACA	5869
1237	UGGUCUCUC UGGUUGUG	1714	CACAACCA CUGAUGAG GNNNNNNNNC CGAA AGAGACCA	5870
1242	UCUCUGGUU GUGUAUGU	1715	ACAUACAC CUGAUGAG GNNNNNNNNC CGAA ACCAGAGA	5871
1247	GGUUGUGUA UGUCCCAC	1716	GUGGGACA CUGAUGAG GNNNNNNNNC CGAA ACACAACC	5872
1251	GUGUAUGUC CCACCCCA	1717	UGGGGUGG CUGAUGAG GNNNNNNNNC CGAA ACAUACAC	5873
1263	CCCCAGAUU GGUGAGAA	1718	UUCUCACC CUGAUGAG GNNNNNNNNC CGAA AUCUGGGG	5874
1274	UGAGAAAUC UCUAAUCU	1719	AGAUUAGA CUGAUGAG GNNNNNNNNC CGAA AUUUCUCA	5875
1275	AGAAAUCUC UAAUCUCU	1720	AGAGAUUA CUGAUGAG GNNNNNNNNC CGAA AGAUUUCU	5876
1278	AAAUCUCUA AUCUCUCC	1721	GGAGAGAU CUGAUGAG GNNNNNNNNC CGAA AGAGAUUU	5877
1281	UCUCUAAUC UCUCCUGU	1722	ACAGGAGA CUGAUGAG GNNNNNNNNC CGAA AUUAGAGA	5878
1283	UCUAAUCUC UCCUGUGG	1723	CCACAGGA CUGAUGAG GNNNNNNNNC CGAA AGAUUAGA	5879
1285	UAAUCUCUC CUGUGGAU	1724	AUCCACAG CUGAUGAG GNNNNNNNNC CGAA AGAGAUUA	5880
1294	CUGUGGAUU CCUACCAG	1725	CUGGUAGG CUGAUGAG GNNNNNNNNC CGAA AUCCACAG	5881
1295	UGUGGAUUC CUACCAGU	1726	ACUGGUAG CUGAUGAG GNNNNNNNNC CGAA AAUCCACA	5882
1298	GGAUUCCUA CCAGUACG	1727	CGUACUGG CUGAUGAG GNNNNNNNNC CGAA AGGAAUCC	5883
1304	CUACCAGUA CGGCACCA	1728	UGGUGCCG CUGAUGAG GNNNNNNNNC CGAA ACUGGUAG	5884
1315	GCACCACUC AAACGCUG	1729	CAGCGUUU CUGAUGAG GNNNNNNNNC CGAA AGUGGUGC	5885
1330	UGACAUGUA CGGUCUAU	1730	AUAGACCG CUGAUGAG GNNNNNNNNC CGAA ACAUGUCA	5886
1335	UGUACGGUC UAUGCCAU	1731	AUGGCAUA CUGAUGAG GNNNNNNNNC CGAA ACCGUACA	5887
1337	UACGGUCUA UGCCAUUC	1732	GAAUGGCA CUGAUGAG GNNNNNNNNC CGAA AGACCGUA	5888
1344	UAUGCCAUU CCUCCCCC	1733	GGGGGAGG CUGAUGAG GNNNNNNNNC CGAA AUGGCAUA	5889
1345	AUGCCAUUC CUCCCCCG	1734	CGGGGGAG CUGAUGAG GNNNNNNNNC CGAA AAUGGCAU	5890
1348	CCAUUCCUC CCCCGCAU	1735	AUGCGGGG CUGAUGAG GNNNNNNNNC CGAA AGGAAUGG	5891
1357	CCCCGCAUC ACAUCCAC	1736	GUGGAUGU CUGAUGAG GNNNNNNNNC CGAA AUGCGGGG	5892
1362	CAUCACAUC CACUGGUA	1737	UACCAGUG CUGAUGAG GNNNNNNNNC CGAA AUGUGAUG	5893
1370	CCACUGGUA UUGGCAGU	1738	ACUGCCAA CUGAUGAG GNNNNNNNNC CGAA ACCAGUGG	5894
1372	ACUGGUAUU GGCAGUUG	1739	CAACUGCC CUGAUGAG GNNNNNNNNC CGAA AUACCAGU	5895
1379	UUGGCAGUU GGAGGAAG	1740	CUUCCUCC CUGAUGAG GNNNNNNNNC CGAA ACUGCCAA	5896
1416	CAAGCUGUC UCAGUGAC	1741	GUCACUGA CUGAUGAG GNNNNNNNNC CGAA ACAGCUUG	5897
1418	AGCUGUCUC AGUGACAA	1742	UUGUCACU CUGAUGAG GNNNNNNNNC CGAA AGACAGCU	5898
1433	AAACCCAUA CCCUUGUG	1743	CACAAGGG CUGAUGAG GNNNNNNNNC CGAA AUGGGUUU	5899
1438	CAUACCCUU GUGAAGAA	1744	UUCUUCAC CUGAUGAG GNNNNNNNNC CGAA AGGGUAUG	5900
1466	GGAGGACUU CCAGGGAG	1745	CUCCCUGG CUGAUGAG GNNNNNNNNC CGAA AGUCCUCC	5901
1467	GAGGACUUC CAGGGAGG	1746	CCUCCCUG CUGAUGAG GNNNNNNNNC CGAA AAGUCCUC	5902
1480	GAGGAAAUA AAAUUGAA	1747	UUCAAUUU CUGAUGAG GNNNNNNNNC CGAA AUUUCCUC	5903
1485	AAUAAAAUU GAAGUUAA	1748	UUAACUUC CUGAUGAG GNNNNNNNNC CGAA AUUUUAUU	5904
1491	AUUGAAGUU AAUAAAAA	1749	UUUUUAUU CUGAUGAG GNNNNNNNNC CGAA ACUUCAAU	5905
1492	UUGAAGUUA AUAAAAAU	1750	AUUUUUAU CUGAUGAG GNNNNNNNNC CGAA AACUUCAA	5906
1495	AAGUUAAUA AAAAUCAA	1751	UUGAUUUU CUGAUGAG GNNNNNNNNC CGAA AUUAACUU	5907
1501	AUAAAAAUC AAUUUGCU	1752	AGCAAAUU CUGAUGAG GNNNNNNNNC CGAA AUUUUUAU	5908
1505	AAAUCAAUU UGCUCUAA	1753	UUAGAGCA CUGAUGAG GNNNNNNNNC CGAA AUUGAUUU	5909
1506	AAUCAAUUU GCUCUAAU	1754	AUUAGAGC CUGAUGAG GNNNNNNNNC CGAA AAUUGAUU	5910
1510	AAUUUGCUC UAAUUGAA	1755	UUCAAUUA CUGAUGAG GNNNNNNNNC CGAA AGCAAAUU	5911
1512	UUUGCUCUA AUUGAAGG	1756	CCUUCAAU CUGAUGAG GNNNNNNNNC CGAA AGAGCAAA	5912
1515	GCUCUAAUU GAAGGAAA	1757	UUUCCUUC CUGAUGAG GNNNNNNNNC CGAA AUUAGAGC	5913
1536	AAAACUGUA AGUACCCU	1758	AGGGUACU CUGAUGAG GNNNNNNNNC CGAA ACAGUUUU	5914
1540	CUGUAAGUA CCCUUGUU	1759	AACAAGGG CUGAUGAG GNNNNNNNNC CGAA ACUUACAG	5915
1545	AGUACCCUU GUUAUCCA	1760	UGGAUAAC CUGAUGAG GNNNNNNNNC CGAA AGGGUACU	5916
1548	ACCCUUGUU AUCCAAGC	1761	GCUUGGAU CUGAUGAG GNNNNNNNNC CGAA ACAAGGGU	5917
1549	CCCUUGUUA UCCAAGCG	1762	CGCUUGGA CUGAUGAG GNNNNNNNNC CGAA AACAAGGG	5918
1551	CUUGUUAUC CAAGCGGC	1763	GCCGCUUG CUGAUGAG GNNNNNNNNC CGAA AUAACAAG	5919
1568	AAAUGUGUC AGCUUUGU	1764	ACAAAGCU CUGAUGAG GNNNNNNNNC CGAA ACACAUUU	5920
1573	UGUCAGCUU UGUACAAA	1765	UUUGUACA CUGAUGAG GNNNNNNNNC CGAA AGCUGACA	5921
1574	GUCAGCUUU GUACAAAU	1766	AUUUGUAC CUGAUGAG GNNNNNNNNC CGAA AAGCUGAC	5922
1577	AGCUUUGUA CAAAUGUG	1767	CACAUUUG CUGAUGAG GNNNNNNNNC CGAA ACAAAGCU	5923
1593	GAAGCGGUC AACAAAGU	1768	ACUUUGUU CUGAUGAG GNNNNNNNNC CGAA ACCGCUUC	5924
1602	AACAAAGUC GGGAGAGG	1769	CCUCUCCC CUGAUGAG GNNNNNNNNC CGAA ACUUUGUU	5925
1623	AGGGUGAUC UCCUUCCA	1770	UGGAAGGA CUGAUGAG GNNNNNNNNC CGAA AUCACCCU	5926
1625	GGUGAUCUC CUUCCACG	1771	CGUGGAAG CUGAUGAG GNNNNNNNNC CGAA AGAUCACC	5927
1628	GAUCUCCUU CCACGUGA	1772	UCACGUGG CUGAUGAG GNNNNNNNNC CGAA AGGAGAUC	5928
1629	AUCUCCUUC CACGUGAC	1773	GUCACGUG CUGAUGAG GNNNNNNNNC CGAA AAGGAGAU	5929
1645	CCAGGGGUC CUGAAAUU	1774	AAUUUCAG CUGAUGAG GNNNNNNNNC CGAA ACCCCUGG	5930
1653	CCUGAAAUU ACUUUGCA	1775	UGCAAAGU CUGAUGAG GNNNNNNNNC CGAA AUUUCAGG	5931
1654	CUGAAAUUA CUUUGCAA	1776	UUGCAAAG CUGAUGAG GNNNNNNNNC CGAA AAUUUCAG	5932
1657	AAAUUACUU UGCAACCU	1777	AGGUUGCA CUGAUGAG GNNNNNNNNC CGAA AGUAAUUU	5933
1658	AAUUACUUU GCAACCUG	1778	CAGGUUGC CUGAUGAG GNNNNNNNNC CGAA AAGUAAUU	5934
1697	GAGCGUGUC UUUGUGGU	1779	ACCACAAA CUGAUGAG GNNNNNNNNC CGAA ACACGCUC	5935
1699	GCGUGUCUU UGUGGUGC	1780	GCACCACA CUGAUGAG GNNNNNNNNC CGAA AGACACGC	5936
1700	CGUGUCUUU GUGGUGCA	1781	UGCACCAC CUGAUGAG GNNNNNNNNC CGAA AAGACACG	5937
1721	AGACAGAUC UACGUUUG	1782	CAAACGUA CUGAUGAG GNNNNNNNNC CGAA AUCUGUCU	5938
1723	ACAGAUCUA CGUUUGAG	1783	CUCAAACG CUGAUGAG GNNNNNNNNC CGAA AGAUCUGU	5939
1727	AUCUACGUU UGAGAACC	1784	GGUUCUCA CUGAUGAG GNNNNNNNNC CGAA ACGUAGAU	5940
1728	UCUACGUUU GAGAACCU	1785	AGGUUCUC CUGAUGAG GNNNNNNNNC CGAA AACGUAGA	5941
1737	GAGAACCUC ACAUGGUA	1786	UACCAUGU CUGAUGAG GNNNNNNNNC CGAA AGGUUCUC	5942
1745	CACAUGGUA CAAGCUUG	1787	CAAGCUUG CUGAUGAG GNNNNNNNNC CGAA ACCAUGUG	5943
1752	UACAAGCUU GGCCCACA	1788	UGUGGGCC CUGAUGAG GNNNNNNNNC CGAA AGCUUGUA	5944
1765	CACAGCCUC UGCCAAUC	1789	GAUUGGCA CUGAUGAG GNNNNNNNNC CGAA AGGCUGUG	5945
1773	CUGCCAAUC CAUGUGGG	1790	CCCACAUG CUGAUGAG GNNNNNNNNC CGAA AUUGGCAG	5946
1787	GGGAGAGUU GCCCACAC	1791	GUGUGGGC CUGAUGAG GNNNNNNNNC CGAA ACUCUCCC	5947
1800	ACACCUGUU UGCAAGAA	1792	UUCUUGCA CUGAUGAG GNNNNNNNNC CGAA ACAGGUGU	5948
1801	CACCUGUUU GCAAGAAC	1793	GUUCUUGC CUGAUGAG GNNNNNNNNC CGAA AACAGGUG	5949
1811	CAAGAACUU GGAUACUC	1794	GAGUAUCC CUGAUGAG GNNNNNNNNC CGAA AGUUCUUG	5950
1816	ACUUGGAUA CUCUUUGG	1795	CCAAAGAG CUGAUGAG GNNNNNNNNC CGAA AUCCAAGU	5951
1819	UGGAUACUC UUUGGAAA	1796	UUUCCAAA CUGAUGAG GNNNNNNNNC CGAA AGUAUCCA	5952
1821	GAUACUCUU UGGAAAUU	1797	AAUUUCCA CUGAUGAG GNNNNNNNNC CGAA AGAGUAUC	5953
1822	AUACUCUUU GGAAAUUG	1798	CAAUUUCC CUGAUGAG GNNNNNNNNC CGAA AAGAGUAU	5954
1829	UUGGAAAUU GAAUGCCA	1799	UGGCAUUC CUGAUGAG GNNNNNNNNC CGAA AUUUCCAA	5955
1844	CACCAUGUU CUCUAAUA	1800	UAUUAGAG CUGAUGAG GNNNNNNNNC CGAA ACAUGGUG	5956
1845	ACCAUGUUC UCUAAUAG	1801	CUAUUAGA CUGAUGAG GNNNNNNNNC CGAA AACAUGGU	5957
1847	CAUGUUCUC UAAUAGCA	1802	UGCUAUUA CUGAUGAG GNNNNNNNNC CGAA AGAACAUG	5958
1849	UGUUCUCUA AUAGCACA	1803	UGUGCUAU CUGAUGAG GNNNNNNNNC CGAA AGAGAACA	5959
1852	UCUCUAAUA GCACAAAU	1804	AUUUGUGC CUGAUGAG GNNNNNNNNC CGAA AUUAGAGA	5960
1866	AAUGACAUU UUGAUCAU	1805	AUGAUCAA CUGAUGAG GNNNNNNNNC CGAA AUGUCAUU	5961
1867	AUGACAUUU UGAUCAUG	1806	CAUGAUCA CUGAUGAG GNNNNNNNNC CGAA AAUGUCAU	5962
1868	UGACAUUUU GAUCAUGG	1807	CCAUGAUC CUGAUGAG GNNNNNNNNC CGAA AAAUGUCA	5963
1872	AUUUUGAUC AUGGAGCU	1808	AGCUCCAU CUGAUGAG GNNNNNNNNC CGAA AUCAAAAU	5964
1881	AUGGAGCUU AAGAAUGC	1809	GCAUUCUU CUGAUGAG GNNNNNNNNC CGAA AGCUCCAU	5965
1882	UGGAGCUUA AGAAUGCA	1810	UGCAUUCU CUGAUGAG GNNNNNNNNC CGAA AAGCUCCA	5966
1892	GAAUGCAUC CUUGCAGG	1811	CCUGCAAG CUGAUGAG GNNNNNNNNC CGAA AUGCAUUC	5967
1895	UGCAUCCUU GCAGGACC	1812	GGUCCUGC CUGAUGAG GNNNNNNNNC CGAA AGGAUGCA	5968
1913	AGGAGACUA UGUCUGCC	1813	GGCAGACA CUGAUGAG GNNNNNNNNC CGAA AGUCUCCU	5969
1917	GACUAUGUC UGCCUUGC	1814	GCAAGGCA CUGAUGAG GNNNNNNNNC CGAA ACAUAGUC	5970
1923	GUCUGCCUU GCUCAAGA	1815	UCUUGAGC CUGAUGAG GNNNNNNNNC CGAA AGGCAGAC	5971
1927	GCCUUGCUC AAGACAGG	1816	CCUGUCUU CUGAUGAG GNNNNNNNNC CGAA AGCAAGGC	5972
1954	AAAGACAUU GCGUGGUC	1817	GACCACGC CUGAUGAG GNNNNNNNNC CGAA AUGUCUUU	5973
1962	UGCGUGGUC AGGCAGCU	1818	AGCUGCCU CUGAUGAG GNNNNNNNNC CGAA ACCACGCA	5974
1971	AGGCAGCUC ACAGUCCU	1819	AGGACUGU CUGAUGAG GNNNNNNNNC CGAA AGCUGCCU	5975
1977	CUCACAGUC CUAGAGCG	1820	CGCUCUAG CUGAUGAG GNNNNNNNNC CGAA ACUGUGAG	5976
1980	ACAGUCCUA GAGCGUGU	1821	ACACGCUC CUGAUGAG GNNNNNNNNC CGAA AGGACUGU	5977
2001	CCCACGAUC ACAGGAAA	1822	UUUCCUGU CUGAUGAG GNNNNNNNNC CGAA AUCGUGGG	5978
2020	UGGAGAAUC AGACGACA	1823	UGUCGUCU CUGAUGAG GNNNNNNNNC CGAA AUUCUCCA	5979
2032	CGACAAGUA UUGGGGAA	1824	UUCCCCAA CUGAUGAG GNNNNNNNNC CGAA ACUUGUCG	5980
2034	ACAAGUAUU GGGGAAAG	1825	CUUUCCCC CUGAUGAG GNNNNNNNNC CGAA AUACUUGU	5981
2046	GAAAGCAUC GAAGUCUC	1826	GAGACUUC CUGAUGAG GNNNNNNNNC CGAA AUGCUUUC	5982
2052	AUCGAAGUC UCAUGCAC	1827	GUGCAUGA CUGAUGAG GNNNNNNNNC CGAA ACUUCGAU	5983
2054	CGAAGUCUC AUGCACGG	1828	CCGUGCAU CUGAUGAG GNNNNNNNNC CGAA AGACUUCG	5984
2066	CACGGCAUC UGGGAAUC	1829	GAUUCCCA CUGAUGAG GNNNNNNNNC CGAA AUGCCGUG	5985
2074	CUGGGAAUC CCCCUCCA	1830	UGGAGGGG CUGAUGAG GNNNNNNNNC CGAA AUUCCCAG	5986
2080	AUCCCCCUC CACAGAUC	1831	GAUCUGUG CUGAUGAG GNNNNNNNNC CGAA AGGGGGAU	5987
2088	CCACAGAUC AUGUGGUU	1832	AACCACAU CUGAUGAG GNNNNNNNNC CGAA AUCUGUGG	5988
2096	CAUGUGGUU UAAAGAUA	1833	UAUCUUUA CUGAUGAG GNNNNNNNNC CGAA ACCACAUG	5989
2097	AUGUGGUUU AAAGAUAA	1834	UUAUCUUU CUGAUGAG GNNNNNNNNC CGAA AACCACAU	5990
2098	UGUGGUUUA AAGAUAAU	1835	AUUAUCUU CUGAUGAG GNNNNNNNNC CGAA AAACCACA	5991
2104	UUAAAGAUA AUGAGACC	1836	GGUCUCAU CUGAUGAG GNNNNNNNNC CGAA AUCUUUAA	5992
2115	GAGACCCUU GUAGAAGA	1837	UCUUCUAC CUGAUGAG GNNNNNNNNC CGAA AGGGUCUC	5993
2118	ACCCUUGUA GAAGACUC	1838	GAGUCUUC CUGAUGAG GNNNNNNNNC CGAA ACAAGGGU	5994
2126	AGAAGACUC AGGCAUUG	1839	CAAUGCCU CUGAUGAG GNNNNNNNNC CGAA AGUCUUCU	5995
2133	UCAGGCAUU GUAUUGAA	1840	UUCAAUAC CUGAUGAG GNNNNNNNNC CGAA AUGCCUGA	5996
2136	GGCAUUGUA UUGAAGGA	1841	UCCUUCAA CUGAUGAG GNNNNNNNNC CGAA ACAAUGCC	5997
2138	CAUUGUAUU GAAGGAUG	1842	CAUCCUUC CUGAUGAG GNNNNNNNNC CGAA AUACAAUG	5998
2160	CGGAACCUC ACUAUCCG	1843	CGGAUAGU CUGAUGAG GNNNNNNNNC CGAA AGGUUCCG	5999
2164	ACCUCACUA UCCGCAGA	1844	UCUGCGGA CUGAUGAG GNNNNNNNNC CGAA AGUGAGGU	6000
2166	CUCACUAUC CGCAGAGU	1845	ACUCUGCG CUGAUGAG GNNNNNNNNC CGAA AUAGUGAG	6001
2196	GAAGGCCUC UACACCUG	1846	CAGGUGUA CUGAUGAG GNNNNNNNNC CGAA AGGCCUUC	6002
2198	AGGCCUCUA CACCUGCC	1847	GGCAGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGGCCU	6003
2220	UGCAGUGUU CUUGGCUG	1848	CAGCCAAG CUGAUGAG GNNNNNNNNC CGAA ACACUGCA	6004
2221	GCAGUGUUC UUGGCUGU	1849	ACAGCCAA CUGAUGAG GNNNNNNNNC CGAA AACACUGC	6005
2223	AGUGUUCUU GGCUGUGC	1850	GCACAGCC CUGAUGAG GNNNNNNNNC CGAA AGAACACU	6006
2246	GGAGGCAUU UUUCAUAA	1851	UUAUGAAA CUGAUGAG GNNNNNNNNC CGAA AUGCCUCC	6007
2247	GAGGCAUUU UUCAUAAU	1852	AUUAUGAA CUGAUGAG GNNNNNNNNC CGAA AAUGCCUC	6008
2248	AGGCAUUUU UCAUAAUA	1853	UAUUAUGA CUGAUGAG GNNNNNNNNC CGAA AAAUGCCU	6009
2249	GGCAUUUUU CAUAAUAG	1854	CUAUUAUG CUGAUGAG GNNNNNNNNC CGAA AAAAUGCC	6010
2250	GCAUUUUUC AUAAUAGA	1855	UCUAUUAU CUGAUGAG GNNNNNNNNC CGAA AAAAAUGC	6011
2253	UUUUUCAUA AUAGAAGG	1856	CCUUCUAU CUGAUGAG GNNNNNNNNC CGAA AUGAAAAA	6012
2256	UUCAUAAUA GAAGGUGC	1857	GCACCUUC CUGAUGAG GNNNNNNNNC CGAA AUUAUGAA	6013
2282	GACGAACUU GGAAAUCA	1858	UGAUUUCC CUGAUGAG GNNNNNNNNC CGAA AGUUCGUC	6014
2289	UUGGAAAUC AUUAUUCU	1859	AGAAUAAU CUGAUGAG GNNNNNNNNC CGAA AUUUCCAA	6015
2292	GAAAUCAUU AUUCUAGU	1860	ACUAGAAU CUGAUGAG GNNNNNNNNC CGAA AUGAUUUC	6016
2293	AAAUCAUUA UUCUAGUA	1861	UACUAGAA CUGAUGAG GNNNNNNNNC CGAA AAUGAUUU	6017
2295	AUCAUUAUU CUAGUAGG	1862	CCUACUAG CUGAUGAG GNNNNNNNNC CGAA AUAAUGAU	6018
2296	UCAUUAUUC UAGUAGGC	1863	GCCUACUA CUGAUGAG GNNNNNNNNC CGAA AAUAAUGA	6019
2298	AUUAUUCUA GUAGGCAC	1864	GUGCCUAC CUGAUGAG GNNNNNNNNC CGAA AGAAUAAU	6020
2301	AUUCUAGUA GGCACGAC	1865	GUCGUGCC CUGAUGAG GNNNNNNNNC CGAA ACUAGAAU	6021
2316	ACGGUGAUU GCCAUGUU	1866	AACAUGGC CUGAUGAG GNNNNNNNNC CGAA AUCACCGU	6022
2324	UGCCAUGUU CUUCUGGC	1867	GCCAGAAG CUGAUGAG GNNNNNNNNC CGAA ACAUGGCA	6023
2325	GCCAUGUUC UUCUGGCU	1868	AGCCAGAA CUGAUGAG GNNNNNNNNC CGAA AACAUGGC	6024
2327	CAUGUUCUU CUGGCUAC	1869	GUAGCCAG CUGAUGAG GNNNNNNNNC CGAA AGAACAUG	6025
2328	AUGUUCUUC UGGCUACU	1870	AGUAGCCA CUGAUGAG GNNNNNNNNC CGAA AAGAACAU	6026
2334	UUCUGGCUA CUUCUUGU	1871	ACAAGAAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGAA	6027
2337	UGGCUACUU CUUGUCAU	1872	AUGACAAG CUGAUGAG GNNNNNNNNC CGAA AGUAGCCA	6028
2338	GGCUACUUC UUGUCAUC	1873	GAUGACAA CUGAUGAG GNNNNNNNNC CGAA AAGUAGCC	6029
2340	CUACUUCUU GUCAUCAU	1874	AUGAUGAC CUGAUGAG GNNNNNNNNC CGAA AGAAGUAG	6030
2343	CUUCUUGUC AUCAUCCU	1875	AGGAUGAU CUGAUGAG GNNNNNNNNC CGAA ACAAGAAG	6031
2346	CUUGUCAUC AUCCUAGG	1876	CCUAGGAU CUGAUGAG GNNNNNNNNC CGAA AUGACAAG	6032
2349	GUCAUCAUC CUAGGGAC	1877	GUCCCUAG CUGAUGAG GNNNNNNNNC CGAA AUGAUGAC	6033
2352	AUCAUCCUA GGGACCGU	1878	ACGGUCCC CUGAUGAG GNNNNNNNNC CGAA AGGAUGAU	6034
2361	GGGACCGUU AAGCGGGC	1879	GCCCGCUU CUGAUGAG GNNNNNNNNC CGAA ACGGUCCC	6035
2362	GGACCGUUA AGCGGGCC	1880	GGCCCGCU CUGAUGAG GNNNNNNNNC CGAA AACGGUCC	6036
2396	GACAGGCUA CUUGUCCA	1881	UGGACAAG CUGAUGAG GNNNNNNNNC CGAA AGCCUGUC	6037
2399	AGGCUACUU GUCCAUCG	1882	CGAUGGAC CUGAUGAG GNNNNNNNNC CGAA AGUAGCCU	6038
2402	CUACUUGUC CAUCGUCA	1883	UGACGAUG CUGAUGAG GNNNNNNNNC CGAA ACAAGUAG	6039
2406	UUGUCCAUC GUCAUGGA	1884	UCCAUGAC CUGAUGAG GNNNNNNNNC CGAA AUGGACAA	6040
2409	UCCAUCGUC AUGGAUCC	1885	GGAUCCAU CUGAUGAG GNNNNNNNNC CGAA ACGAUGGA	6041
2416	UCAUGGAUC CAGAUGAA	1886	UUCAUCUG CUGAUGAG GNNNNNNNNC CGAA AUCCAUGA	6042
2427	GAUGAACUC CCAUUGGA	1887	UCCAAUGG CUGAUGAG GNNNNNNNNC CGAA AGUUCAUC	6043
2432	ACUCCCAUU GGAUGAAC	1888	GUUCAUCC CUGAUGAG GNNNNNNNNC CGAA AUGGGAGU	6044
2443	AUGAACAUU GUGAACGA	1889	UCGUUCAC CUGAUGAG GNNNNNNNNC CGAA AUGUUCAU	6045
2458	GACUGCCUU AUGAUGCC	1890	GGCAUCAU CUGAUGAG GNNNNNNNNC CGAA AGGCAGUC	6046
2459	ACUGCCUUA UGAUGCCA	1891	UGGCAUCA CUGAUGAG GNNNNNNNNC CGAA AAGGCAGU	6047
2480	AUGGGAAUU CCCCAGAG	1892	CUCUGGGG CUGAUGAG GNNNNNNNNC CGAA AUUCCCAU	6048
2481	UGGGAAUUC CCCAGAGA	1893	UCUCUGGG CUGAUGAG GNNNNNNNNC CGAA AAUUCCCA	6049
2502	CUGAACCUA GGUAAGCC	1894	GGCUUACC CUGAUGAG GNNNNNNNNC CGAA AGGUUCAG	6050
2506	ACCUAGGUA AGCCUCUU	1895	AAGAGGCU CUGAUGAG GNNNNNNNNC CGAA ACCUAGGU	6051
2512	GUAAGCCUC UUGGCCGU	1896	ACGGCCAA CUGAUGAG GNNNNNNNNC CGAA AGGCUUAC	6052
2514	AAGCCUCUU GGCCGUGG	1897	CCACGGCC CUGAUGAG GNNNNNNNNC CGAA AGAGGCUU	6053
2528	UGGUGCCUU UGGCCAAG	1898	CUUGGCCA CUGAUGAG GNNNNNNNNC CGAA AGGCACCA	6054
2529	GGUGCCUUU GGCCAAGA	1899	UCUUGGCC CUGAUGAG GNNNNNNNNC CGAA AAGGCACC	6055
2541	CAAGAGAUU GAAGCAGA	1900	UCUGCUUC CUGAUGAG GNNNNNNNNC CGAA AUCUCUUG	6056
2555	AGAUGCCUU UGGAAUUG	1901	CAAUUCCA CUGAUGAG GNNNNNNNNC CGAA AGGCAUCU	6057
2556	GAUGCCUUU GGAAUUGA	1902	UCAAUUCC CUGAUGAG GNNNNNNNNC CGAA AAGGCAUC	6058
2562	UUUGGAAUU GACAAGAC	1903	GUCUUGUC CUGAUGAG GNNNNNNNNC CGAA AUUCCAAA	6059
2578	CAGCAACUU GCAGGACA	1904	UGUCCUGC CUGAUGAG GNNNNNNNNC CGAA AGUUGCUG	6060
2589	AGGACAGUA GCAGUCAA	1905	UUGACUGC CUGAUGAG GNNNNNNNNC CGAA ACUGUCCU	6061
2595	GUAGCAGUC AAAAUGUU	1906	AACAUUUU CUGAUGAG GNNNNNNNNC CGAA ACUGCUAC	6062
2603	CAAAAUGUU GAAAGAAG	1907	CUUCUUUC CUGAUGAG GNNNNNNNNC CGAA ACAUUUUG	6063
2632	GUGAGCAUC GAGCUCUC	1908	GAGAGCUC CUGAUGAG GNNNNNNNNC CGAA AUGCUCAC	6064
2638	AUCGAGCUC UCAUGUCU	1909	AGACAUGA CUGAUGAG GNNNNNNNNC CGAA AGCUCGAU	6065
2640	CGAGCUCUC AUGUCUGA	1910	UCAGACAU CUGAUGAG GNNNNNNNNC CGAA AGAGCUCG	6066
2645	UCUCAUGUC UGAACUCA	1911	UGAGUUCA CUGAUGAG GNNNNNNNNC CGAA ACAUGAGA	6067
2652	UCUGAACUC AAGAUCCU	1912	AGGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGUUCAGA	6068
2658	CUCAAGAUC CUCAUUCA	1913	UGAAUGAG CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	6069
2661	AAGAUCCUC AUUCAUAU	1914	AUAUGAAU CUGAUGAG GNNNNNNNNC CGAA AGGAUCUU	6070
2664	AUCCUCAUU CAUAUUGG	1915	CCAAUAUG CUGAUGAG GNNNNNNNNC CGAA AUGAGGAU	6071
2665	UCCUCAUUC AUAUUGGU	1916	ACCAAUAU CUGAUGAG GNNNNNNNNC CGAA AAUGAGGA	6072
2668	UCAUUCAUA UUGGUCAC	1917	GUGACCAA CUGAUGAG GNNNNNNNNC CGAA AUGAAUGA	6073
2670	AUUCAUAUU GGUCACCA	1918	UGGUGACC CUGAUGAG GNNNNNNNNC CGAA AUAUGAAU	6074
2674	AUAUUGGUC ACCAUCUC	1919	GAGAUGGU CUGAUGAG GNNNNNNNNC CGAA ACCAAUAU	6075
2680	GUCACCAUC UCAAUGUG	1920	CACAUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGUGAC	6076
2682	CACCAUCUC AAUGUGGU	1921	ACCACAUU CUGAUGAG GNNNNNNNNC CGAA AGAUGGUG	6077
2691	AAUGUGGUC AACCUUCU	1922	AGAAGGUU CUGAUGAG GNNNNNNNNC CGAA ACCACAUU	6078
2697	GUCAACCUU CUAGGUGC	1923	GCACCUAG CUGAUGAG GNNNNNNNNC CGAA AGGUUGAC	6079
2698	UCAACCUUC UAGGUGCC	1924	GGCACCUA CUGAUGAG GNNNNNNNNC CGAA AAGGUUGA	6080
2700	AACCUUCUA GGUGCCUG	1925	CAGGCACC CUGAUGAG GNNNNNNNNC CGAA AGAAGGUU	6081
2710	GUGCCUGUA CCAAGCCA	1926	UGGCUUGG CUGAUGAG GNNNNNNNNC CGAA ACAGGCAC	6082
2730	GGGCCACUC AUGGUGAU	1927	AUCACCAU CUGAUGAG GNNNNNNNNC CGAA AGUGGCCC	6083
2739	AUGGUGAUU GUGGAAUU	1928	AAUUCCAC CUGAUGAG GNNNNNNNNC CGAA AUCACCAU	6084
2747	UGUGGAAUU CUGCAAAU	1929	AUUUGCAG CUGAUGAG GNNNNNNNNC CGAA AUUCCACA	6085
2748	GUGGAAUUC UGCAAAUU	1930	AAUUUGCA CUGAUGAG GNNNNNNNNC CGAA AAUUCCAC	6086
2756	CUGCAAAUU UGGAAACC	1931	GGUUUCCA CUGAUGAG GNNNNNNNNC CGAA AUUUGCAG	6087
2757	UGCAAAUUU GGAAACCU	1932	AGGUUUCC CUGAUGAG GNNNNNNNNC CGAA AAUUUGCA	6088
2768	AAACCUGUC CACUUACC	1933	GGUAAGUG CUGAUGAG GNNNNNNNNC CGAA ACAGGUUU	6089
2773	UGUCCACUU ACCUGAGG	1934	CCUCAGGU CUGAUGAG GNNNNNNNNC CGAA AGUGGACA	6090
2774	GUCCACUUA CCUGAGGA	1935	UCCUCAGG CUGAUGAG GNNNNNNNNC CGAA AAGUGGAC	6091
2798	AAAUGAAUU UGUCCCCU	1936	AGGGGACA CUGAUGAG GNNNNNNNNC CGAA AUUCAUUU	6092
2799	AAUGAAUUU GUCCCCUA	1937	UAGGGGAC CUGAUGAG GNNNNNNNNC CGAA AAUUCAUU	6093
2802	GAAUUUGUC CCCUACAA	1938	UUGUAGGG CUGAUGAG GNNNNNNNNC CGAA ACAAAUUC	6094
2807	UGUCCCCUA CAAGACCA	1939	UGGUCUUG CUGAUGAG GNNNNNNNNC CGAA AGGGGACA	6095
2828	GGCACGAUU CCGUCAAG	1940	CUUGACGG CUGAUGAG GNNNNNNNNC CGAA AUCGUGCC	6096
2829	GCACGAUUC CGUCAAGG	1941	CCUUGACG CUGAUGAG GNNNNNNNNC CGAA AAUCGUGC	6097
2833	GAUUCCGUC AAGGGAAA	1942	UUUCCCUU CUGAUGAG GNNNNNNNNC CGAA ACGGAAUC	6098
2846	GAAAGACUA CGUUGGAG	1943	CUCCAACG CUGAUGAG GNNNNNNNNC CGAA AGUCUUUC	6099
2850	GACUACGUU GGAGCAAU	1944	AUUGCUCC CUGAUGAG GNNNNNNNNC CGAA ACGUAGUC	6100
2859	GGAGCAAUC CCUGUGGA	1945	UCCACAGG CUGAUGAG GNNNNNNNNC CGAA AUUGCUCC	6101
2869	CUGUGGAUC UGAAACGG	1946	CCGUUUCA CUGAUGAG GNNNNNNNNC CGAA AUCCACAG	6102
2882	ACGGCGCUU GGACAGCA	1947	UGCUGUCC CUGAUGAG GNNNNNNNNC CGAA AGCGCCGU	6103
2892	GACAGCAUC ACCAGUAG	1948	CUACUGGU CUGAUGAG GNNNNNNNNC CGAA AUGCUGUC	6104
2899	UCACCAGUA GCCAGAGC	1949	GCUCUGGC CUGAUGAG GNNNNNNNNC CGAA ACUGGUGA	6105
2909	CCAGAGCUC AGCCAGCU	1950	AGCUGGCU CUGAUGAG GNNNNNNNNC CGAA AGCUCUGG	6106
2918	AGCCAGCUC UGGAUUUG	1951	CAAAUCCA CUGAUGAG GNNNNNNNNC CGAA AGCUGGCU	6107
2924	CUCUGGAUU UGUGGAGG	1952	CCUCCACA CUGAUGAG GNNNNNNNNC CGAA AUCCAGAG	6108
2925	UCUGGAUUU GUGGAGGA	1953	UCCUCCAC CUGAUGAG GNNNNNNNNC CGAA AAUCCAGA	6109
2939	GGAGAAGUC CCUCAGUG	1954	CACUGAGG CUGAUGAG GNNNNNNNNC CGAA ACUUCUCC	6110
2943	AAGUCCCUC AGUGAUGU	1955	ACAUCACU CUGAUGAG GNNNNNNNNC CGAA AGGGACUU	6111
2952	AGUGAUGUA GAAGAAGA	1956	UCUUCUUC CUGAUGAG GNNNNNNNNC CGAA ACAUCACU	6112
2968	AGGAAGCUC CUGAAGAU	1957	AUCUUCAG CUGAUGAG GNNNNNNNNC CGAA AGCUUCCU	6113
2977	CUGAAGAUC UGUAUAAG	1958	CUUAUACA CUGAUGAG GNNNNNNNNC CGAA AUCUUCAG	6114
2981	AGAUCUGUA UAAGGACU	1959	AGUCCUUA CUGAUGAG GNNNNNNNNC CGAA ACAGAUCU	6115
2983	AUCUGUAUA AGGACUUC	1960	GAAGUCCU CUGAUGAG GNNNNNNNNC CGAA AUACAGAU	6116
2990	UAAGGACUU CCUGACCU	1961	AGGUCAGG CUGAUGAG GNNNNNNNNC CGAA AGUCCUUA	6117
2991	AAGGACUUC CUGACCUU	1962	AAGGUCAG CUGAUGAG GNNNNNNNNC CGAA AAGUCCUU	6118
2999	CCUGACCUU GGAGCAUC	1963	GAUGCUCC CUGAUGAG GNNNNNNNNC CGAA AGGUCAGG	6119
3007	UGGAGCAUC UCAUCUGU	1964	ACAGAUGA CUGAUGAG GNNNNNNNNC CGAA AUGCUCCA	6120
3009	GAGCAUCUC AUCUGUUA	1965	UAACAGAU CUGAUGAG GNNNNNNNNC CGAA AGAUGCUC	6121
3012	CAUCUCAUC UGUUACAG	1966	CUGUAACA CUGAUGAG GNNNNNNNNC CGAA AUGAGAUG	6122
3016	UCAUCUGUU ACAGCUUC	1967	GAAGCUGU CUGAUGAG GNNNNNNNNC CGAA ACAGAUGA	6123
3017	CAUCUGUUA CAGCUUCC	1968	GGAAGCUG CUGAUGAG GNNNNNNNNC CGAA AACAGAUG	6124
3023	UUACAGCUU CCAAGUGG	1969	CCACUUGG CUGAUGAG GNNNNNNNNC CGAA AGCUGUAA	6125
3024	UACAGCUUC CAAGUGGC	1970	GCCACUUG CUGAUGAG GNNNNNNNNC CGAA AAGCUGUA	6126
3034	AAGUGGCUA AGGGCAUG	1971	CAUGCCCU CUGAUGAG GNNNNNNNNC CGAA AGCCACUU	6127
3047	CAUGGAGUU CUUGGCAU	1972	AUGCCAAG CUGAUGAG GNNNNNNNNC CGAA ACUCCAUG	6128
3048	AUGGAGUUC UUGGCAUC	1973	GAUGCCAA CUGAUGAG GNNNNNNNNC CGAA AACUCCAU	6129
3050	GGAGUUCUU GGCAUCGC	1974	GCGAUGCC CUGAUGAG GNNNNNNNNC CGAA AGAACUCC	6130
3056	CUUGGCAUC GCGAAAGU	1975	ACUUUCGC CUGAUGAG GNNNNNNNNC CGAA AUGCCAAG	6131
3067	GAAAGUGUA UCCACAGG	1976	CCUGUGGA CUGAUGAG GNNNNNNNNC CGAA ACACUUUC	6132
3069	AAGUGUAUC CACAGGGA	1977	UCCCUGUG CUGAUGAG GNNNNNNNNC CGAA AUACACUU	6133
3094	CACGAAAUA UCCUCUUA	1978	UAAGAGGA CUGAUGAG GNNNNNNNNC CGAA AUUUCGUG	6134
3096	CGAAAUAUC CUCUUAUC	1979	GAUAAGAG CUGAUGAG GNNNNNNNNC CGAA AUAUUUCG	6135
3099	AAUAUCCUC UUAUCGGA	1980	UCCGAUAA CUGAUGAG GNNNNNNNNC CGAA AGGAUAUU	6136
3101	UAUCCUCUU AUCGGAGA	1981	UCUCCGAU CUGAUGAG GNNNNNNNNC CGAA AGAGGAUA	6137
3102	AUCCUCUUA UCGGAGAA	1982	UUCUCCGA CUGAUGAG GNNNNNNNNC CGAA AAGAGGAU	6138
3104	CCUCUUAUC GGAGAAGA	1983	UCUUCUCC CUGAUGAG GNNNNNNNNC CGAA AUAAGAGG	6139
3120	AACGUGGUU AAAAUCUG	1984	CAGAUUUU CUGAUGAG GNNNNNNNNC CGAA ACCACGUU	6140
3121	ACGUGGUUA AAAUCUGU	1985	ACAGAUUU CUGAUGAG GNNNNNNNNC CGAA AACCACGU	6141
3126	GUUAAAAUC UGUGACUU	1986	AAGUCACA CUGAUGAG GNNNNNNNNC CGAA AUUUUAAC	6142
3134	CUGUGACUU UGGCUUGG	1987	CCAAGCCA CUGAUGAG GNNNNNNNNC CGAA AGUCACAG	6143
3135	UGUGACUUU GGCUUGGC	1988	GCCAAGCC CUGAUGAG GNNNNNNNNC CGAA AAGUCACA	6144
3140	CUUUGGCUU GGCCCGGG	1989	CCCGGGCC CUGAUGAG GNNNNNNNNC CGAA AGCCAAAG	6145
3151	CCCGGGAUA UUUAUAAA	1990	UUUAUAAA CUGAUGAG GNNNNNNNNC CGAA AUCCCGGG	6146
3153	CGGGAUAUU UAUAAAGA	1991	UCUUUAUA CUGAUGAG GNNNNNNNNC CGAA AUAUCCCG	6147
3154	GGGAUAUUU AUAAAGAU	1992	AUCUUUAU CUGAUGAG GNNNNNNNNC CGAA AAUAUCCC	6148
3155	GGAUAUUUA UAAAGAUC	1993	GAUCUUUA CUGAUGAG GNNNNNNNNC CGAA AAAUAUCC	6149
3157	AUAUUUAUA AAGAUCCA	1994	UGGAUCUU CUGAUGAG GNNNNNNNNC CGAA AUAAAUAU	6150
3163	AUAAAGAUC CAGAUUAU	1995	AUAAUCUG CUGAUGAG GNNNNNNNNC CGAA AUCUUUAU	6151
3169	AUCCAGAUU AUGUCAGA	1996	UCUGACAU CUGAUGAG GNNNNNNNNC CGAA AUCUGGAU	6152
3170	UCCAGAUUA UGUCAGAA	1997	UUCUGACA CUGAUGAG GNNNNNNNNC CGAA AAUCUGGA	6153
3174	GAUUAUGUC AGAAAAGG	1998	CCUUUUCU CUGAUGAG GNNNNNNNNC CGAA ACAUAAUC	6154
3190	GAGAUGCUC GCCUCCCU	1999	AGGGAGGC CUGAUGAG GNNNNNNNNC CGAA AGCAUCUC	6155
3195	GCUCGCCUC CCUUUGAA	2000	UUCAAAGG CUGAUGAG GNNNNNNNNC CGAA AGGCGAGC	6156
3199	GCCUCCCUU UGAAAUGG	2001	CCAUUUCA CUGAUGAG GNNNNNNNNC CGAA AGGGAGGC	6157
3200	CCUCCCUUU GAAAUGGA	2002	UCCAUUUC CUGAUGAG GNNNNNNNNC CGAA AAGGGAGG	6158
3225	GAAACAAUU UUUGACAG	2003	CUGUCAAA CUGAUGAG GNNNNNNNNC CGAA AUUGUUUC	6159
3226	AAACAAUUU UUGACAGA	2004	UCUGUCAA CUGAUGAG GNNNNNNNNC CGAA AAUUGUUU	6160
3227	AACAAUUUU UGACAGAG	2005	CUCUGUCA CUGAUGAG GNNNNNNNNC CGAA AAAUUGUU	6161
3228	ACAAUUUUU GACAGAGU	2006	ACUCUGUC CUGAUGAG GNNNNNNNNC CGAA AAAAUUGU	6162
3239	CAGAGUGUA CACAAUCC	2007	GGAUUGUG CUGAUGAG GNNNNNNNNC CGAA ACACUCUG	6163
3246	UACACAAUC CAGAGUGA	2008	UCACUCUG CUGAUGAG GNNNNNNNNC CGAA AUUGUGUA	6164
3258	AGUGACGUC UGGUCUUU	2009	AAAGACCA CUGAUGAG GNNNNNNNNC CGAA ACGUCACU	6165
3263	CGUCUGGUC UUUUGGUG	2010	CACCAAAA CUGAUGAG GNNNNNNNNC CGAA ACCAGACG	6166
3265	UCUGGUCUU UUGGUGUU	2011	AACACCAA CUGAUGAG GNNNNNNNNC CGAA AGACCAGA	6167
3266	CUGGUCUUU UGGUGUUU	2012	AAACACCA CUGAUGAG GNNNNNNNNC CGAA AAGACCAG	6168
3267	UGGUCUUUU GGUGUUUU	2013	AAAACACC CUGAUGAG GNNNNNNNNC CGAA AAAGACCA	6169
3273	UUUGGUGUU UUGCUGUG	2014	CACAGCAA CUGAUGAG GNNNNNNNNC CGAA ACACCAAA	6170
3274	UUGGUGUUU UGCUGUGG	2015	CCACAGCA CUGAUGAG GNNNNNNNNC CGAA AACACCAA	6171
3275	UGGUGUUUU GCUGUGGG	2016	CCCACAGC CUGAUGAG GNNNNNNNNC CGAA AAACACCA	6172
3288	UGGGAAAUA UUUUCCUU	2017	AAGGAAAA CUGAUGAG GNNNNNNNNC CGAA AUUUCCCA	6173
3290	GGAAAUAUU UUCCUUAG	2018	CUAAGGAA CUGAUGAG GNNNNNNNNC CGAA AUAUUUCC	6174
3291	GAAAUAUUU UCCUUAGG	2019	CCUAAGGA CUGAUGAG GNNNNNNNNC CGAA AAUAUUUC	6175
3292	AAAUAUUUU CCUUAGGU	2020	ACCUAAGG CUGAUGAG GNNNNNNNNC CGAA AAAUAUUU	6176
3293	AAUAUUUUC CUUAGGUG	2021	CACCUAAG CUGAUGAG GNNNNNNNNC CGAA AAAAUAUU	6177
3296	AUUUUCCUU AGGUGCUU	2022	AAGCACCU CUGAUGAG GNNNNNNNNC CGAA AGGAAAAU	6178
3297	UUUUCCUUA GGUGCUUC	2023	GAAGCACC CUGAUGAG GNNNNNNNNC CGAA AAGGAAAA	6179
3304	UAGGUGCUU CUCCAUAU	2024	AUAUGGAG CUGAUGAG GNNNNNNNNC CGAA AGCACCUA	6180
3305	AGGUGCUUC UCCAUAUC	2025	GAUAUGGA CUGAUGAG GNNNNNNNNC CGAA AAGCACCU	6181
3307	GUGCUUCUC CAUAUCCU	2026	AGGAUAUG CUGAUGAG GNNNNNNNNC CGAA AGAAGCAC	6182
3311	UUCUCCAUA UCCUGGGG	2027	CCCCAGGA CUGAUGAG GNNNNNNNNC CGAA AUGGAGAA	6183
3313	CUCCAUAUC CUGGGGUA	2028	UACCCCAG CUGAUGAG GNNNNNNNNC CGAA AUAUGGAG	6184
3321	CCUGGGGUA AAGAUUGA	2029	UCAAUCUU CUGAUGAG GNNNNNNNNC CGAA ACCCCAGG	6185
3327	GUAAAGAUU GAUGAAGA	2030	UCUUCAUC CUGAUGAG GNNNNNNNNC CGAA AUCUUUAC	6186
3338	UGAAGAAUU UUGUAGGC	2031	GCCUACAA CUGAUGAG GNNNNNNNNC CGAA AUUCUUCA	6187
3339	GAAGAAUUU UGUAGGCG	2032	CGCCUACA CUGAUGAG GNNNNNNNNC CGAA AAUUCUUC	6188
3340	AAGAAUUUU GUAGGCGA	2033	UCGCCUAC CUGAUGAG GNNNNNNNNC CGAA AAAUUCUU	6189
3343	AAUUUUGUA GGCGAUUG	2034	CAAUCGCC CUGAUGAG GNNNNNNNNC CGAA ACAAAAUU	6190
3350	UAGGCGAUU GAAAGAAG	2035	CUUCUUUC CUGAUGAG GNNNNNNNNC CGAA AUCGCCUA	6191
3364	AAGGAACUA GAAUGAGG	2036	CCUCAUUC CUGAUGAG GNNNNNNNNC CGAA AGUUCCUU	6192
3382	CCCCUGAUU AUACUACA	2037	UGUAGUAU CUGAUGAG GNNNNNNNNC CGAA AUCAGGGG	6193
3383	CCCUGAUUA UACUACAC	2038	GUGUAGUA CUGAUGAG GNNNNNNNNC CGAA AAUCAGGG	6194
3385	CUGAUUAUA CUACACCA	2039	UGGUGUAG CUGAUGAG GNNNNNNNNC CGAA AUAAUCAG	6195
3388	AUUAUACUA CACCAGAA	2040	UUCUGGUG CUGAUGAG GNNNNNNNNC CGAA AGUAUAAU	6196
3401	AGAAAUGUA CCAGACCA	2041	UGGUCUGG CUGAUGAG GNNNNNNNNC CGAA ACAUUUCU	6197
3439	AGCCCAGUC AGAGACCC	2042	GGGUCUCU CUGAUGAG GNNNNNNNNC CGAA ACUGGGCU	6198
3452	ACCCACGUU UUCAGAGU	2043	ACUCUGAA CUGAUGAG GNNNNNNNNC CGAA ACGUGGGU	6199
3453	CCCACGUUU UCAGAGUU	2044	AACUCUGA CUGAUGAG GNNNNNNNNC CGAA AACGUGGG	6200
3454	CCACGUUUU CAGAGUUG	2045	CAACUCUG CUGAUGAG GNNNNNNNNC CGAA AAACGUGG	6201
3455	CACGUUUUC AGAGUUGG	2046	CCAACUCU CUGAUGAG GNNNNNNNNC CGAA AAAACGUG	6202
3461	UUCAGAGUU GGUGGAAC	2047	GUUCCACC CUGAUGAG GNNNNNNNNC CGAA ACUCUGAA	6203
3472	UGGAACAUU UGGGAAAU	2048	AUUUCCCA CUGAUGAG GNNNNNNNNC CGAA AUGUUCCA	6204
3473	GGAACAUUU GGGAAAUC	2049	GAUUUCCC CUGAUGAG GNNNNNNNNC CGAA AAUGUUCC	6205
3481	UGGGAAAUC UCUUGCAA	2050	UUGCAAGA CUGAUGAG GNNNNNNNNC CGAA AUUUCCCA	6206
3483	GGAAAUCUC UUGCAAGC	2051	GCUUGCAA CUGAUGAG GNNNNNNNNC CGAA AGAUUUCC	6207
3485	AAAUCUCUU GCAAGCUA	2052	UAGCUUGC CUGAUGAG GNNNNNNNNC CGAA AGAGAUUU	6208
3493	UGCAAGCUA AUGCUCAG	2053	CUGAGCAU CUGAUGAG GNNNNNNNNC CGAA AGCUUGCA	6209
3499	CUAAUGCUC AGCAGGAU	2054	AUCCUGCU CUGAUGAG GNNNNNNNNC CGAA AGCAUUAG	6210
3518	CAAAGACUA CAUUGUUC	2055	GAACAAUG CUGAUGAG GNNNNNNNNC CGAA AGUCUUUG	6211
3522	GACUACAUU GUUCUUCC	2056	GGAAGAAC CUGAUGAG GNNNNNNNNC CGAA AUGUAGUC	6212
3525	UACAUUGUU CUUCCGAU	2057	AUCGGAAG CUGAUGAG GNNNNNNNNC CGAA ACAAUGUA	6213
3526	ACAUUGUUC UUCCGAUA	2058	UAUCGGAA CUGAUGAG GNNNNNNNNC CGAA AACAAUGU	6214
3528	AUUGUUCUU CCGAUAUC	2059	GAUAUCGG CUGAUGAG GNNNNNNNNC CGAA AGAACAAU	6215
3529	UUGUUCUUC CGAUAUCA	2060	UGAUAUCG CUGAUGAG GNNNNNNNNC CGAA AAGAACAA	6216
3534	CUUCCGAUA UCAGAGAC	2061	GUCUCUGA CUGAUGAG GNNNNNNNNC CGAA AUCGGAAG	6217
3536	UCCGAUAUC AGAGACUU	2062	AAGUCUCU CUGAUGAG GNNNNNNNNC CGAA AUAUCGGA	6218
3544	CAGAGACUU UGAGCAUG	2063	CAUGCUCA CUGAUGAG GNNNNNNNNC CGAA AGUCUCUG	6219
3545	AGAGACUUU GAGCAUGG	2064	CCAUGCUC CUGAUGAG GNNNNNNNNC CGAA AAGUCUCU	6220
3562	AAGAGGAUU CUGGACUC	2065	GAGUCCAG CUGAUGAG GNNNNNNNNC CGAA AUCCUCUU	6221
3563	AGAGGAUUC UGGACUCU	2066	AGAGUCCA CUGAUGAG GNNNNNNNNC CGAA AAUCCUCU	6222
3570	UCUGGACUC UCUCUGCC	2067	GGCAGAGA CUGAUGAG GNNNNNNNNC CGAA AGUCCAGA	6223
3572	UGGACUCUC UCUGCCUA	2068	UAGGCAGA CUGAUGAG GNNNNNNNNC CGAA AGAGUCCA	6224
3574	GACUCUCUC UGCCUACC	2069	GGUAGGCA CUGAUGAG GNNNNNNNNC CGAA AGAGAGUC	6225
3580	CUCUGCCUA CCUCACCU	2070	AGGUGAGG CUGAUGAG GNNNNNNNNC CGAA AGGCAGAG	6226
3584	GCCUACCUC ACCUGUUU	2071	AAACAGGU CUGAUGAG GNNNNNNNNC CGAA AGGUAGGC	6227
3591	UCACCUGUU UCCUGUAU	2072	AUACAGGA CUGAUGAG GNNNNNNNNC CGAA ACAGGUGA	6228
3592	CACCUGUUU CCUGUAUG	2073	CAUACAGG CUGAUGAG GNNNNNNNNC CGAA AACAGGUG	6229
3593	ACCUGUUUC CUGUAUGG	2074	CCAUACAG CUGAUGAG GNNNNNNNNC CGAA AAACAGGU	6230
3598	UUUCCUGUA UGGAGGAG	2075	CUCCUCCA CUGAUGAG GNNNNNNNNC CGAA ACAGGAAA	6231
3615	GAGGAAGUA UGUGACCC	2076	GGGUCACA CUGAUGAG GNNNNNNNNC CGAA ACUUCCUC	6232
3629	CCCCAAAUU CCAUUAUG	2077	CAUAAUGG CUGAUGAG GNNNNNNNNC CGAA AUUUGGGG	6233
3630	CCCAAAUUC CAUUAUGA	2078	UCAUAAUG CUGAUGAG GNNNNNNNNC CGAA AAUUUGGG	6234
3634	AAUUCCAUU AUGACAAC	2079	GUUGUCAU CUGAUGAG GNNNNNNNNC CGAA AUGGAAUU	6235
3653	AUUCCAUUA UGACAACA	2080	UGUUGUCA CUGAUGAG GNNNNNNNNC CGAA AAUGGAAU	6236
3654	GCAGGAAUC AGUCAGUA	2081	UACUGACU CUGAUGAG GNNNNNNNNC CGAA AUUCCUGC	6237
3658	GAAUCAGUC AGUAUCUG	2082	CAGAUACU CUGAUGAG GNNNNNNNNC CGAA ACUGAUUC	6238
3662	CAGUCAGUA UCUGCAGA	2083	UCUGCAGA CUGAUGAG GNNNNNNNNC CGAA ACUGACUG	6239
3664	GUCAGUAUC UGCAGAAC	2084	GUUCUGCA CUGAUGAG GNNNNNNNNC CGAA AUACUGAC	6240
3676	AGAACAGUA AGCGAAAG	2085	CUUUCGCU CUGAUGAG GNNNNNNNNC CGAA ACUGUUCU	6241
3702	GUGAGUGUA AAAACAUU	2086	AAUGUUUU CUGAUGAG GNNNNNNNNC CGAA ACACUCAC	6242
3710	AAAAACAUU UGAAGAUA	2087	UAUCUUCA CUGAUGAG GNNNNNNNNC CGAA AUGUUUUU	6243
3711	AAAACAUUU GAAGAUAU	2088	AUAUCUUC CUGAUGAG GNNNNNNNNC CGAA AAUGUUUU	6244
3718	UUGAAGAUA UCCCGUUA	2089	UAACGGGA CUGAUGAG GNNNNNNNNC CGAA AUCUUCAA	6245
3720	GAAGAUAUC CCGUUAGA	2090	UCUAACGG CUGAUGAG GNNNNNNNNC CGAA AUAUCUUC	6246
3725	UAUCCCGUU AGAAGAAC	2091	GUUCUUCU CUGAUGAG GNNNNNNNNC CGAA ACGGGAUA	6247
3726	AUCCCGUUA GAAGAACC	2092	GGUUCUUC CUGAUGAG GNNNNNNNNC CGAA AACGGGAU	6248
3741	CCAGAAGUA AAAGUAAU	2093	AUUACUUU CUGAUGAG GNNNNNNNNC CGAA ACUUCUGG	6249
3747	GUAAAAGUA AUCCCAGA	2094	UCUGGGAU CUGAUGAG GNNNNNNNNC CGAA ACUUUUAC	6250
3750	AAAGUAAUC CCAGAUGA	2095	UCAUCUGG CUGAUGAG GNNNNNNNNC CGAA AUUACUUU	6251
3778	ACAGUGGUA UGGUUCUU	2096	AAGAACCA CUGAUGAG GNNNNNNNNC CGAA ACCACUGU	6252
3783	GGUAUGGUU CUUGCCUC	2097	GAGGCAAG CUGAUGAG GNNNNNNNNC CGAA ACCAUACC	6253
3784	GUAUGGUUC UUGCCUCA	2098	UGAGGCAA CUGAUGAG GNNNNNNNNC CGAA AACCAUAC	6254
3786	AUGGUUCUU GCCUCAGA	2099	UCUGAGGC CUGAUGAG GNNNNNNNNC CGAA AGAACCAU	6255
3791	UCUUGCCUC AGAAGAGC	2100	GCUCUUCU CUGAUGAG GNNNNNNNNC CGAA AGGCAAGA	6256
3808	UGAAAACUU UGGAAGAC	2101	GUCUUCCA CUGAUGAG GNNNNNNNNC CGAA AGUUUUCA	6257
3809	GAAAACUUU GGAAGACA	2102	UGUCUUCC CUGAUGAG GNNNNNNNNC CGAA AAGUUUUC	6258
3827	AACCAAAUU AUCUCCAU	2103	AUGGAGAU CUGAUGAG GNNNNNNNNC CGAA AUUUGGUU	6259
3828	ACCAAAUUA UCUCCAUC	2104	GAUGGAGA CUGAUGAG GNNNNNNNNC CGAA AAUUUGGU	6260
3830	CAAAUUAUC UCCAUCUU	2105	AAGAUGGA CUGAUGAG GNNNNNNNNC CGAA AUAAUUUG	6261
3832	AAUUAUCUC CAUCUUUU	2106	AAAAGAUG CUGAUGAG GNNNNNNNNC CGAA AGAUAAUU	6262
3836	AUCUCCAUC UUUUGGUG	2107	CACCAAAA CUGAUGAG GNNNNNNNNC CGAA AUGGAGAU	6263
3838	CUCCAUCUU UUGGUGGA	2108	UCCACCAA CUGAUGAG GNNNNNNNNC CGAA AGAUGGAG	6264
3839	UCCAUCUUU UGGUGGAA	2109	UUCCACCA CUGAUGAG GNNNNNNNNC CGAA AAGAUGGA	6265
3840	CCAUCUUUU GGUGGAAU	2110	AUUCCACC CUGAUGAG GNNNNNNNNC CGAA AAAGAUGG	6266
3872	CAGGGAGUC UGUGGCAU	2111	AUGCCACA CUGAUGAG GNNNNNNNNC CGAA ACUCCCUG	6267
3881	UGUGGCAUC UGAAGGCU	2112	AGCCUUCA CUGAUGAG GNNNNNNNNC CGAA AUGCCACA	6268
3890	UGAAGGCUC AAACCAGA	2113	UCUGGUUU CUGAUGAG GNNNNNNNNC CGAA AGCCUUCA	6269
3908	AAGCGGCUA CCAGUCCG	2114	CGGACUGG CUGAUGAG GNNNNNNNNC CGAA AGCCGCUU	6270
3914	CUACCAGUC CGGAUAUC	2115	GAUAUCCG CUGAUGAG GNNNNNNNNC CGAA ACUGGUAG	6271
3920	GUCCGGAUA UCACUCCG	2116	CGGAGUGA CUGAUGAG GNNNNNNNNC CCAA AUCCGGAC	6272
3922	CCGGAUAUC ACUCCGAU	2117	AUCGGAGU CUGAUGAG GNNNNNNNNC CGAA AUAUCCGG	6273
3926	AUAUCACUC CGAUGACA	2118	UGUCAUCG CUGAUGAG GNNNNNNNNC CCAA AGUGAUAU	6274
3950	CACCGUGUA CUCCAGUG	2119	CACUGGAG CUGAUGAG GNNNNNNNNC CGAA ACACGGUG	6275
3953	CGUGUACUC CAGUGAGG	2120	CCUCACUG CUGAUGAG GNNNNNNNNC CGAA AGUACACG	6276
3972	GCAGAACUU UUAAAGCU	2121	AGCUUUAA CUGAUGAG GNNNNNNNNC CGAA AGUUCUGC	6277
3973	CAGAACUUU UAAAGCUG	2122	CAGCUUUA CUGAUGAG GNNNNNNNNC CGAA AAGUUCUG	6278
3974	AGAACUUUU AAAGCUGA	2123	UCAGCUUU CUGAUGAG GNNNNNNNNC CGAA AAAGUUCU	6279
3975	GAACUUUUA AAGCUGAU	2124	AUCAGCUU CUGAUGAG GNNNNNNNNC CGAA AAAAGUUC	6280
3984	AAGCUGAUA GAGAUUGG	2125	CCAAUCUC CUGAUGAG GNNNNNNNNC CGAA AUCAGCUU	6281
3990	AUAGAGAUU GGAGUGCA	2126	UGCACUCC CUGAUGAG GNNNNNNNNC CGAA AUCUCUAU	6282
4006	AAACCGGUA GCACAGCC	2127	GGCUGUGC CUGAUGAG GNNNNNNNNC CGAA ACCGGUUU	6283
4020	GCCCAGAUU CUCCAGCC	2128	GGCUGGAG CUGAUGAG GNNNNNNNNC CGAA AUCUGGGC	6284
4021	CCCAGAUUC UCCAGCCU	2129	AGGCUGGA CUGAUGAG GNNNNNNNNC CGAA AAUCUGGG	6285
4023	CAGAUUCUC CAGCCUGA	2130	UCAGGCUG CUGAUGAG GNNNNNNNNC CGAA AGAAUCUG	6286
4052	ACUGAGCUC UCCUCCUG	2131	CAGGAGGA CUGAUGAG GNNNNNNNNC CGAA AGCUCAGU	6287
4054	UGAGCUCUC CUCCUGUU	2132	AACAGGAG CUGAUGAG GNNNNNNNNC CGAA AGAGCUCA	6288
4057	GCUCUCCUC CUGUUUAA	2133	UUAAACAG CUGAUGAG GNNNNNNNNC CGAA AGGAGAGC	6289
4062	CCUCCUGUU UAAAAGGA	2134	UCCUUUUA CUGAUGAG GNNNNNNNNC CGAA ACAGGAGG	6290
4063	CUCCUGUUU AAAAGGAA	2135	UUCCUUUU CUGAUGAG GNNNNNNNNC CGAA AACAGGAG	6291
4064	UCCUGUUUA AAAGGAAG	2136	CUUCCUUU CUGAUGAG GNNNNNNNNC CGAA AAACAGGA	6292
4076	GGAAGCAUC CACACCCC	2137	GGGGUGUG CUGAUGAG GNNNNNNNNC CGAA AUGCUUCC	6293
4089	CCCCAACUC CCGGACAU	2138	AUGUCCGG CUGAUGAG GNNNNNNNNC CGAA AGUUGGGG	6294
4098	CCGGACAUC ACAUGAGA	2139	UCUCAUGU CUGAUGAG GNNNNNNNNC CGAA AUGUCCGG	6295
4110	UGAGAGGUC UGCUCAGA	2140	UCUGAGCA CUGAUGAG GNNNNNNNNC CGAA ACCUCUCA	6296
4115	GGUCUGCUC AGAUUUUG	2141	CAAAAUCU CUGAUGAG GNNNNNNNNC CGAA AGCAGACC	6297
4120	GCUCAGAUU UUGAAGUG	2142	CACUUCAA CUGAUGAG GNNNNNNNNC CGAA AUCUGAGC	6298
4121	CUCAGAUUU UGAAGUGU	2143	ACACUUCA CUGAUGAG GNNNNNNNNC CGAA AAUCUGAG	6299
4122	UCAGAUUUU GAAGUGUU	2144	AACACUUC CUGAUGAG GNNNNNNNNC CGAA AAAUCUGA	6300
4130	UGAAGUGUU GUUCUUUC	2145	GAAAGAAC CUGAUGAG GNNNNNNNNC CGAA ACACUUCA	6301
4133	AGUGUUGUU CUUUCCAC	2146	GUGGAAAG CUGAUGAG GNNNNNNNNC CGAA ACAACACU	6302
4134	GUGUUGUUC UUUCCACC	2147	GGUGGAAA CUGAUGAG GNNNNNNNNC CGAA AACAACAC	6303
4136	GUUGUUCUU UCCACCAG	2148	CUGGUGGA CUGAUGAG GNNNNNNNNC CGAA AGAACAAC	6304
4137	UUGUUCUUU CCACCAGC	2149	GCUGGUGG CUGAUGAG GNNNNNNNNC CGAA AAGAACAA	6305
4138	UGUUCUUUC CACCAGCA	2150	UGCUGGUG CUGAUGAG GNNNNNNNNC CGAA AAAGAACA	6306
4153	CAGGAAGUA GCCGCAUU	2151	AAUGCGGC CUGAUGAG GNNNNNNNNC CGAA ACUUCCUG	6307
4161	AGCCGCAUU UGAUUUUC	2152	GAAAAUCA CUGAUGAG GNNNNNNNNC CGAA AUGCGGCU	6308
4162	GCCGCAUUU GAUUUUCA	2153	UGAAAAUC CUGAUGAG GNNNNNNNNC CGAA AAUGCGGC	6309
4166	CAUUUGAUU UUCAUUUC	2154	GAAAUGAA CUGAUGAG GNNNNNNNNC CGAA AUCAAAUG	6310
4167	AUUUGAUUU UCAUUUCG	2155	CGAAAUGA CUGAUGAG GNNNNNNNNC CGAA AAUCAAAU	6311
4168	UUUGAUUUU CAUUUCGA	2156	UCGAAAUG CUGAUGAG GNNNNNNNNC CGAA AAAUCAAA	6312
4169	UUGAUUUUC AUUUCGAC	2157	GUCGAAAU CUGAUGAG GNNNNNNNNC CGAA AAAAUCAA	6313
4172	AUUUUCAUU UCGACAAC	2158	GUUGUCGA CUGAUGAG GNNNNNNNNC CGAA AUGAAAAU	6314
4173	UUUUCAUUU CGACAACA	2159	UGUUGUCG CUGAUGAG GNNNNNNNNC CGAA AAUGAAAA	6315
4174	UUUCAUUUC GACAACAG	2160	CUGUUGUC CUGAUGAG GNNNNNNNNC CGAA AAAUGAAA	6316
4194	AAGGACCUC GGACUGCA	2161	UGCAGUCC CUGAUGAG GNNNNNNNNC CGAA AGGUCCUU	6317
4214	AGCCAGCUC UUCUAGGC	2162	GCCUAGAA CUGAUGAG GNNNNNNNNC CGAA AGCUGGCU	6318
4216	CCAGCUCUU CUAGGCUU	2163	AAGCCUAG CUGAUGAG GNNNNNNNNC CGAA AGAGCUGG	6319
4217	CAGCUCUUC UAGGCUUG	2164	CAAGCCUA CUGAUGAG GNNNNNNNNC CGAA AAGAGCUG	6320
4219	GCUCUUCUA GGCUUGUG	2165	CACAAGCC CUGAUGAG GNNNNNNNNC CGAA AGAAGAGC	6321
Where “X” represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be >2 base-pairs.
Underlined region can be any X sequence or linker, as described herein.

TABLE V
Human KDR VEGF Receptor-Hairpin Ribozyme and Substrate Sequences
	Seq		Seq
	ID		ID
Pos Substrate	No	HP Ribozyme Sequence	No
11 AGGUGCU GCU GGCCGUCG	2166	CGACGGCC AGAA GCACCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6322
18 GCUGGCC GUC GCCCUGUG	2167	CACAGGGC AGAA GCCAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6323
51 CCGGGCC GCC UCUGUGGG	2168	CCCACAGA AGAA GCCCGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6324
86 UUGAUCU GCC CAGGCUCA	2169	UGAGCCUG AGAA GAUCAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6325
318 GGAAACU GAC UUGGCCUC	2170	GAGGCCAA AGAA GUUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6326
358 GAUUACA GAU CUCCAUUU	2171	AAAUGGAG AGAA GUAAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6327
510 UGUUCCU GAU GGUAACAG	2172	CUGUUACC AGAA GGAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6328
623 GUUACCA GUC UAUUAUGU	2173	ACAUAAUA AGAA GGUAAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6329
683 UGAGUCC GUC UCAUGGAA	2174	UUCCAUGA AGAA GACUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6330
705 ACUAUCU GUU GGAGAAAA	2175	UUUUCUCC AGAA GAUAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6331
833 AAACCCA GUC UGGGAGUG	2176	CACUCCCA AGAA GGGUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6332
932 GUGGGCU GAU GACCAAGA	2177	UCUUGGUC AGAA GCCCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6333
1142 AUGUACU GAC GAUUAUGG	2178	CCAUAAUC AGAA GUACAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6334
1259 CACCCCA GAU UGGUGAGA	2179	UCUCACCA AGAA GGGGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6335
1332 AUGUACG GUC UAUGCCAU	2180	AUGGCAUA AGAA GUACAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6336
1376 AUUGGCA GUU GGAGGAAG	2181	CUUCCUCC AGAA GCCAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6337
1413 CCAAGCU GUC UCAGUGAC	2182	GUCACUGA AGAA GCUUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6338
1569 UGUGUCA GCU UUGUACAA	2183	UUGUACAA AGAA GACACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6339
1673 ACAUGCA GCC CACUGAGC	2184	GCUCAGUG AGAA GCAUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6340
1717 GCAGACA GAU CUACGUUU	2185	AAACGUAG AGAA GUCUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6341
1760 GCCCACA GCC UCUGCCAA	2186	UUGGCAGA AGAA GUGGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6342
1797 CACACCU GUU UGCAAGAA	2187	UUCUUGCA AGAA GGUGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6343
1918 UAUGUCU GCC UUGCUCAA	2188	UUGAGCAA AGAA GACAUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6344
1967 UCAGGCA GCU CACAGUCC	2189	GGACUGUG AGAA GCCUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6345
1974 GCUCACA GUC CUAGAGCG	2190	CGCUCUAG AGAA GUGAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6346
2021 AGAAUCA GAC GACAAGUA	2191	UACUUGUC AGAA GAUUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6347
2084 CUCCACA GAU CAUGUGGU	2192	ACCACAUG AGAA GUGGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6348
2418 GGAUCCA GAU GAACUCCC	2193	GGGAGUUC AGAA GGAUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6349
2453 AACGACU GCC UUAUGAUG	2194	CAUCAUAA AGAA GUCGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6350
2492 GAGACCG GCU GAACCUAG	2195	CUAGGUUC AGAA GGUCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6351
2547 UGAAGCA GAU GCCUUUGG	2196	CCAAAGGC AGAA GCUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6352
2765 GAAACCU GUC CACUUACC	2197	GGUAAGUG AGAA GGUUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6353
2914 UCAGCCA GCU CUGGAUUU	2198	AAAUCCAG AGAA GGCUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6354
2993 ACUUCCU GAC CUUGGAGC	2199	GCUCCAAG AGAA GGAAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6355
3019 UGUUACA GCU UCCAAGUG	2200	CACUUGGA AGAA GUAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6356
3165 AGAUCCA GAU UAUGUCAG	2201	CUGACAUA AGAA GGAUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6357
3378 GGCCCCU GAU UAUACUAC	2202	GUAGUAUA AGAA GGGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6358
3404 UGUACCA GAC CAUGCUGG	2203	CCAGCAUG AGAA GGUACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6359
3418 CUGGACU GCU GGCACGGG	2204	CCCGUGCC AGAA GUCCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6360
3575 UCUCUCU GCC UACCUCAC	2205	GUGAGGUA AGAA GAGAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6361
3588 CUCACCU GUU UCCUGUAU	2206	AUACAGGA AGAA GGUGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6362
3689 AGAGCCG GCC UGUGAGUG	2207	CACUCACA AGAA GGCUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6363
3753 AAUCCCA GAU GACAACCA	2208	UGGUUGUC AGAA GGGAUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6364
3764 ACAACCA GAC GGACAGUG	2209	CACUGUCC AGAA GGUUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6365
3911 GCUACCA GUC CGGAUAUC	2210	GAUAUCCG AGAA GGUAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6366
3927 UCACUCC GAU GACACAGA	2211	UCUGUGUC AGAA GAGUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6367
4011 UAGCACA GCC CAGAUUCU	2212	AGAAUCUG AGAA GUGCUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6368
4016 CAGCCCA GAU UCUCCAGC	2213	GCUGGAGA AGAA GGGCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6369
4025 UUCUCCA GCC UGACACGG	2214	CCGUGUCA AGAA GGAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6370
4059 UCCUCCU GUU UAAAAGGA	2215	UCCUUUUA AGAA GGAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6371
4111 GAGGUCU GCU CAGAUUUU	2216	AAAAUCUG AGAA GACCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6372
4116 CUGCUCA GAU UUUGAAGU	2217	ACUUCAAA AGAA GAGCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6373
4195 GACCUCG GAC UGCAGGGA	2218	UCCCUGCA AGAA GAGGUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6374
4210 GGAGCCA GCU CUUCUAGG	2219	CCUAGAAG AGAA GGCUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6375

TABLE VI
Mouse flk-1 VEGF Receptor-Hammerhead Ribozyme and Substrate Sequence
		Seq		Seq
		ID		ID
Pos	Substrate	No	HH Ribozyme Sequence	No
13	GGGCGAAUU GGGUACGG	2220	CCGUACCC CUGAUGAG GNNNNNNNNC CGAA AUUCGCCC	6376
18	AAUUGGGUA CGGGACCC	2221	GGGUCCCG CUGAUGAG GNNNNNNNNC CGAA ACCCAAUU	6377
31	ACCCCCCUC GAGGUCGA	2222	UCGACCUC CUGAUGAG GNNNNNNNNC CGAA AGGGGGGU	6378
37	CUCGAGGUC GACGGUAU	2223	AUACCGUC CUGAUGAG GNNNNNNNNC CGAA ACCUCGAG	6379
44	UCGACGGUA UCGAUAAG	2224	CUUAUCGA CUGAUGAG GNNNNNNNNC CGAA ACCGUCGA	6380
46	GACGGUAUC GAUAAGCU	2225	AGCUUAUC CUGAUGAG GNNNNNNNNC CGAA AUACCGUC	6381
50	GUAUCGAUA AGCUUGAU	2226	AUCAAGCU CUGAUGAG GNNNNNNNNC CGAA AUCGAUAC	6382
55	GAUAAGCUU GAUAUCGA	2227	UCGAUAUC CUGAUGAG GNNNNNNNNC CGAA AGCUUAUC	6383
59	AGCUUGAUA UCGAAUUC	2228	GAAUUCGA CUGAUGAG GNNNNNNNNC CGAA AUCAAGCU	6384
61	CUUGAUAUC GAAUUCGG	2229	CCGAAUUC CUGAUGAG GNNNNNNNNC CGAA AUAUCAAG	6385
66	UAUCGAAUU CGGGCCCA	2230	UGGGCCCG CUGAUGAG GNNNNNNNNC CGAA AUUCGAUA	6386
67	AUCGAAUUC GGGCCCAG	2231	CUGGGCCC CUGAUGAG GNNNNNNNNC CGAA AAUUCGAU	6387
83	GACUGUGUC CCGCAGCC	2232	GGCUGCGG CUGAUGAG GNNNNNNNNC CGAA ACACAGUC	6388
97	GCCGGGAUA ACCUGGCU	2233	AGCCAGGU CUGAUGAG GNNNNNNNNC CGAA AUCCCGGC	6389
114	GACCCGAUU CCGCGGAC	2234	GUCCGCGG CUGAUGAG GNNNNNNNNC CGAA AUCGGGUC	6390
115	ACCCGAUUC CGCGGACA	2235	UGUCCGCG CUGAUGAG GNNNNNNNNC CGAA AAUCGGGU	6391
169	CCCGCGCUC UCCCCGGU	2236	ACCGGGGA CUGAUGAG GNNNNNNNNC CGAA AGCGCGGG	6392
171	CGCGCUCUC CCCGGUCU	2237	AGACCGGG CUGAUGAG GNNNNNNNNC CGAA AGAGCGCG	6393
178	UCCCCGGUC UUGCGCUG	2238	CAGCGCAA CUGAUGAG GNNNNNNNNC CGAA ACCGGGGA	6394
180	CCCGGUCUU GCGCUGCG	2239	CGCAGCGC CUGAUGAG GNNNNNNNNC CGAA AGACCGGG	6395
197	GGGGCCAUA CCGCCUCU	2240	AGAGGCGG CUGAUGAG GNNNNNNNNC CGAA AUGGCCCC	6396
204	UACCGCCUC UGUGACUU	2241	AAGUCACA CUGAUGAG GNNNNNNNNC CGAA AGGCGGUA	6397
212	CUGUGACUU CUUUGCGG	2242	CCGCAAAG CUGAUGAG GNNNNNNNNC CGAA AGUCACAG	6398
213	UGUGACUUC UUUGCGGG	2243	CCCGCAAA CUGAUGAG GNNNNNNNNC CGAA AAGUCACA	6399
215	UGACUUCUU UGCGGGCC	2244	GGCCCGCA CUGAUGAG GNNNNNNNNC CGAA AGAAGUCA	6400
216	GACUUCUUU GCGGGCCA	2245	UGGCCCGC CUGAUGAG GNNNNNNNNC CGAA AAGAAGUC	6401
241	GAAGGAGUC UGUGCCUG	2246	CAGGCACA CUGAUGAG GNNNNNNNNC CGAA ACUCCUUC	6402
262	ACUGGGCUC UGUGCCCA	2247	UGGGCACA CUGAUGAG GNNNNNNNNC CGAA AGCCCAGU	6403
306	GCGCUGCUA GCUGUCGC	2248	GCGACAGC CUGAUGAG GNNNNNNNNC CGAA AGCAGCGC	6404
312	CUAGCUGUC GCUCUGUG	2249	CACAGAGC CUGAUGAG GNNNNNNNNC CGAA ACAGCUAG	6405
316	CUGUCGCUC UGUGGUUC	2250	GAACCACA CUGAUGAG GNNNNNNNNC CGAA AGCGACAG	6406
323	UCUGUGGUU CUGCGUGG	2251	CCACGCAG CUGAUGAG GNNNNNNNNC CGAA ACCACAGA	6407
324	CUGUGGUUC UGCGUGGA	2252	UCCACGCA CUGAUGAG GNNNNNNNNC CGAA AACCACAG	6408
347	AGCCGCCUC UGUGGGUU	2253	AACCCACA CUGAUGAG GNNNNNNNNC CGAA AGGCGGCU	6409
355	CUGUGGGUU UGACUGGC	2254	GCCAGUCA CUGAUGAG GNNNNNNNNC CGAA ACCCACAG	6410
356	UGUGGGUUU GACUGGCG	2255	CGCCAGUC CUGAUGAG GNNNNNNNNC CGAA AACCCACA	6411
367	CUGGCGAUU UUCUCCAU	2256	AUGGAGAA CUGAUGAG GNNNNNNNNC CGAA AUCGCCAG	6412
368	UGGCGAUUU UCUCCAUC	2257	GAUGGAGA CUGAUGAG GNNNNNNNNC CGAA AAUCGCCA	6413
369	GGCGAUUUU CUCCAUCC	2258	GGAUGGAG CUGAUGAG GNNNNNNNNC CGAA AAAUCGCC	6414
370	GCGAUUUUC UCCAUCCC	2259	GGGAUGGA CUGAUGAG GNNNNNNNNC CGAA AAAAUCGC	6415
372	GAUUUUCUC CAUCCCCC	2260	GGGGGAUG CUGAUGAG GNNNNNNNNC CGAA AGAAAAUC	6416
376	UUCUCCAUC CCCCCAAG	2261	CUUGGGGG CUGAUGAG GNNNNNNNNC CGAA AUGGAGAA	6417
387	CCCAAGCUC AGCACACA	2262	UGUGUGCU CUGAUGAG GNNNNNNNNC CGAA AGCUUGGG	6418
405	AAAGACAUA CUGACAAU	2263	AUUGUCAG CUGAUGAG GNNNNNNNNC CGAA AUGUCUUU	6419
414	CUGACAAUU UUGGCAAA	2264	UUUGCCAA CUGAUGAG GNNNNNNNNC CGAA AUUGUCAG	6420
415	UGACAAUUU UGGCAAAU	2265	AUUUGCCA CUGAUGAG GNNNNNNNNC CGAA AAUUGUCA	6421
416	GACAAUUUU GGCAAAUA	2266	UAUUUGCC CUGAUGAG GNNNNNNNNC CGAA AAAUUGUC	6422
424	UGGCAAAUA CAACCCUU	2267	AAGGGUUG CUGAUGAG GNNNNNNNNC CGAA AUUUGCCA	6423
432	ACAACCCUU CAGAUUAC	2268	GUAAUCUG CUGAUGAG GNNNNNNNNC CGAA AGGGUUGU	6424
433	CAACCCUUC AGAUUACU	2269	AGUAAUCU CUGAUGAG GNNNNNNNNC CGAA AAGGGUUG	6425
438	CUUCAGAUU ACUUGCAG	2270	CUGCAAGU CUGAUGAG GNNNNNNNNC CGAA AUCUGAAG	6426
439	UUCAGAUUA CUUGCAGG	2271	CCUGCAAG CUGAUGAG GNNNNNNNNC CGAA AAUCUGAA	6427
442	AGAUUACUU GCAGGGGA	2272	UCCCCUGC CUGAUGAG GNNNNNNNNC CGAA AGUAAUCU	6428
471	GACUGGCUU UGGCCCAA	1534	UUGGGCCA CUGAUGAG GNNNNNNNNC CGAA AGCCAGUC	5690
472	ACUGGCUUU GGCCCAAU	1535	AUUGGGCC CUGAUGAG GNNNNNNNNC CGAA AAGCCAGU	5691
484	CCAAUGCUC AGCGUGAU	2273	AUCACGCU CUGAUGAG GNNNNNNNNC CGAA AGCAUUGG	6429
493	AGCGUGAUU CUGAGGAA	2274	UUCCUCAG CUGAUGAG GNNNNNNNNC CGAA AUCACGCU	6430
494	GCGUGAUUC UGAGGAAA	2275	UUUCCUCA CUGAUGAG GNNNNNNNNC CGAA AAUCACGC	6431
507	GAAAGGGUA UUGGUGAC	2276	GUCACCAA CUGAUGAG GNNNNNNNNC CGAA ACCCUUUC	6432
509	AAGGGUAUU GGUGACUG	2277	CAGUCACC CUGAUGAG GNNNNNNNNC CGAA AUACCCUU	6433
538	GUGACAGUA UCUUCUGC	2278	GCAGAAGA CUGAUGAG GNNNNNNNNC CGAA ACUGUCAC	6434
540	GACAGUAUC UUCUGCAA	2279	UUGCAGAA CUGAUGAG GNNNNNNNNC CGAA AUACUGUC	6435
542	CAGUAUCUU CUGCAAAA	2280	UUUUGCAG CUGAUGAG GNNNNNNNNC CGAA AGAUACUG	6436
543	AGUAUCUUC UGCAAAAC	2281	GUUUUGCA CUGAUGAG GNNNNNNNNC CGAA AAGAUACU	6437
555	AAAACACUC ACCAUUCC	2282	GGAAUGGU CUGAUGAG GNNNNNNNNC CGAA AGUGUUUU	6438
561	CUCACCAUU CCCAGGGU	2283	ACCCUGGG CUGAUGAG GNNNNNNNNC CGAA AUGGUGAG	6439
562	UCACCAUUC CCAGGGUG	2284	CACCCUGG CUGAUGAG GNNNNNNNNC CGAA AAUGGUGA	6440
573	AGGGUGGUU GGAAAUGA	2285	UCAUUUCC CUGAUGAG GNNNNNNNNC CGAA ACCACCCU	6441
583	GAAAUGAUA CUGGAGCC	2286	GGCUCCAG CUGAUGAG GNNNNNNNNC CGAA AUCAUUUC	6442
593	UGGAGCCUA CAAGUGCU	1546	AGCACUUG CUGAUGAG GNNNNNNNNC CGAA AGGCUCCA	5702
602	CAAGUGCUC GUACCGGG	2287	CCCGGUAC CUGAUGAG GNNNNNNNNC CGAA AGCACUUG	6443
605	GUGCUCGUA CCGGGACG	2288	CGUCCCGG CUGAUGAG GNNNNNNNNC CGAA ACGAGCAC	6444
615	CGGGACGUC GACAUAGC	2289	GCUAUGUC CUGAUGAG GNNNNNNNNC CGAA ACGUCCCG	6445
621	GUCGACAUA GCCUCCAC	2290	GUGGAGGC CUGAUGAG GNNNNNNNNC CGAA AUGUCGAC	6446
626	CAUAGCCUC CACUGUUU	2291	AAACAGUG CUGAUGAG GNNNNNNNNC CGAA AGGCUAUG	6447
633	UCCACUGUU UAUGUCUA	2292	UAGACAUA CUGAUGAG GNNNNNNNNC CGAA ACAGUGGA	6448
634	CCACUGUUU AUGUCUAU	2293	AUAGACAU CUGAUGAG GNNNNNNNNC CGAA AACAGUGG	6449
635	CACUGUUUA UGUCUAUG	2294	CAUAGACA CUGAUGAG GNNNNNNNNC CGAA AAACAGUG	6450
639	GUUUAUGUC UAUGUUCG	2295	CGAACAUA CUGAUGAG GNNNNNNNNC CGAA ACAUAAAC	6451
641	UUAUGUCUA UGUUCGAG	2296	CUCGAACA CUGAUGAG GNNNNNNNNC CGAA AGACAUAA	6452
645	GUCUAUGUU CGAGAUUA	2297	UAAUCUCG CUGAUGAG GNNNNNNNNC CGAA ACAUAGAC	6453
646	UCUAUGUUC GAGAUUAC	2298	GUAAUCUC CUGAUGAG GNNNNNNNNC CGAA AACAUAGA	6454
652	UUCGAGAUU ACAGAUCA	2299	UGAUCUGU CUGAUGAG GNNNNNNNNC CGAA AUCUCGAA	6455
653	UCGAGAUUA CAGAUCAC	2300	GUGAUCUG CUGAUGAG GNNNNNNNNC CGAA AAUCUCGA	6456
659	UUACAGAUC ACCAUUCA	2301	UGAAUGGU CUGAUGAG GNNNNNNNNC CGAA AUCUGUAA	6457
665	AUCACCAUU CAUCGCCU	2302	AGGCGAUG CUGAUGAG GNNNNNNNNC CGAA AUGGUGAU	6458
666	UCACCAUUC AUCGCCUC	2303	GAGGCGAU CUGAUGAG GNNNNNNNNC CGAA AAUGGUGA	6459
669	CCAUUCAUC GCCUCUGU	2304	ACAGAGGC CUGAUGAG GNNNNNNNNC CGAA AUGAAUGG	6460
674	CAUCGCCUC UGUCAGUG	2305	CACUGACA CUGAUGAG GNNNNNNNNC CGAA AGGCGAUG	6461
678	GCCUCUGUC AGUGACCA	2306	UGGUCACU CUGAUGAG GNNNNNNNNC CGAA ACAGAGGC	6462
696	CAUGGCAUC GUGUACAU	2307	AUGUACAC CUGAUGAG GNNNNNNNNC CGAA AUGCCAUG	6463
701	CAUCGUGUA CAUCACCG	2308	CGGUGAUG CUGAUGAG GNNNNNNNNC CGAA ACACGAUG	6464
705	GUGUACAUC ACCGAGAA	2309	UUCUCGGU CUGAUGAG GNNNNNNNNC CGAA AUGUACAC	6465
735	GUGGUGAUC CCCUGCCG	2310	CGGCAGGG CUGAUGAG GNNNNNNNNC CGAA AUCACCAC	6466
749	CCGAGGGUC GAUUUCAA	2311	UUGAAAUC CUGAUGAG GNNNNNNNNC CGAA ACCCUCGG	6467
753	GGGUCGAUU UCAAACCU	2312	AGGUUUGA CUGAUGAG GNNNNNNNNC CGAA AUCGACCC	6468
754	GGUCGAUUU CAAACCUC	2313	GAGGUUUG CUGAUGAG GNNNNNNNNC CGAA AAUCGACC	6469
755	GUCGAUUUC AAACCUCA	2314	UGAGGUUU CUGAUGAG GNNNNNNNNC CGAA AAAUCGAC	6470
762	UCAAACCUC AAUGUGUC	2315	GACACAUU CUGAUGAG GNNNNNNNNC CGAA AGGUUUGA	6471
770	CAAUGUGUC UCUUUGCG	2316	CGCAAAGA CUGAUGAG GNNNNNNNNC CGAA ACACAUUG	6472
772	AUGUGUCUC UUUGCGCU	2317	AGCGCAAA CUGAUGAG GNNNNNNNNC CGAA AGACACAU	6473
774	GUGUCUCUU UGCGCUAG	2318	CUAGCGCA CUGAUGAG GNNNNNNNNC CGAA AGAGACAC	6474
775	UGUCUCUUU GCGCUAGG	2319	CCUAGCGC CUGAUGAG GNNNNNNNNC CGAA AAGAGACA	6475
781	UUUGCGCUA GGUAUCCA	2320	UGGAUACC CUGAUGAG GNNNNNNNNC CGAA AGCGCAAA	6476
785	CGCUAGGUA UCCAGAAA	2321	UUUCUGGA CUGAUGAG GNNNNNNNNC CGAA ACCUAGCG	6477
787	CUAGGUAUC CAGAAAAG	2322	CUUUUCUG CUGAUGAG GNNNNNNNNC CGAA AUACCUAG	6478
800	AAAGAGAUU UGUUCCGG	2323	CCGGAACA CUGAUGAG GNNNNNNNNC CGAA AUCUCUUU	6479
801	AAGAGAUUU GUUCCGGA	2324	UCCGGAAC CUGAUGAG GNNNNNNNNC CGAA AAUCUCUU	6480
804	AGAUUUGUU CCGGAUGG	2325	CCAUCCGG CUGAUGAG GNNNNNNNNC CGAA ACAAAUCU	6481
805	GAUUUGUUC CGGAUGGA	2326	UCCAUCCG CUGAUGAG GNNNNNNNNC CGAA AACAAAUC	6482
822	AACAGAAUU UCCUGGGA	1595	UCCCAGGA CUGAUGAG GNNNNNNNNC CGAA AUUCUGUU	5751
823	ACAGAAUUU CCUGGGAC	1596	GUCCCAGG CUGAUGAG GNNNNNNNNC CGAA AAUUCUGU	5752
824	CAGAAUUUC CUGGGACA	1597	UGUCCCAG CUGAUGAG GNNNNNNNNC CGAA AAAUUCUG	5753
840	AGCGAGAUA GGCUUUAC	2327	GUAAAGCC CUGAUGAG GNNNNNNNNC CGAA AUCUCGCU	6483
845	GAUAGGCUU UACUCUCC	2328	GGAGAGUA CUGAUGAG GNNNNNNNNC CGAA AGCCUAUC	6484
846	AUAGGCUUU ACUCUCCC	2329	GGGAGAGU CUGAUGAG GNNNNNNNNC CGAA AAGCCUAU	6485
847	UAGGCUUUA CUCUCCCC	2330	GGGGAGAG CUGAUGAG GNNNNNNNNC CGAA AAAGCCUA	6486
850	GCUUUACUC UCCCCAGU	2331	ACUGGGGA CUGAUGAG GNNNNNNNNC CGAA AGUAAAGC	6487
852	UUUACUCUC CCCAGUUA	2332	UAACUGGG CUGAUGAG GNNNNNNNNC CGAA AGAGUAAA	6488
859	UCCCCAGUU ACAUGAUC	2333	GAUCAUGU CUGAUGAG GNNNNNNNNC CGAA ACUGGGGA	6489
860	CCCCAGUUA CAUGAUCA	2334	UGAUCAUG CUGAUGAG GNNNNNNNNC CGAA AACUGGGG	6490
867	UACAUGAUC AGCUAUGC	1605	GCAUAGCU CUGAUGAG GNNNNNNNNC CGAA AUCAUGUA	5761
872	GAUCAGCUA UGCCGGCA	2335	UGCCGGCA CUGAUGAG GNNNNNNNNC CGAA AGCUGAUC	6491
885	GGCAUGGUC UUCUGUGA	1607	UCACAGAA CUGAUGAG GNNNNNNNNC CGAA ACCAUGCC	5763
887	CAUGGUCUU CUGUGAGG	2336	CCUCACAG CUGAUGAG GNNNNNNNNC CGAA AGACCAUG	6492
888	AUGGUCUUC UGUGAGGC	2337	GCCUCACA CUGAUGAG GNNNNNNNNC CGAA AAGACCAU	6493
903	GCAAAGAUC AAUGAUGA	2338	UCAUCAUU CUGAUGAG GNNNNNNNNC CGAA AUCUUUGC	6494
917	UGAAACCUA UCAGUCUA	2339	UAGACUGA CUGAUGAG GNNNNNNNNC CGAA AGGUUUCA	6495
919	AAACCUAUC AGUCUAUC	2340	GAUAGACU CUGAUGAG GNNNNNNNNC CGAA AUAGGUUU	6496
923	CUAUCAGUC UAUCAUGU	2341	ACAUGAUA CUGAUGAG GNNNNNNNNC CGAA ACUGAUAG	6497
925	AUCAGUCUA UCAUGUAC	2342	GUACAUGA CUGAUGAG GNNNNNNNNC CGAA AGACUGAU	6498
927	CAGUCUAUC AUGUACAU	2343	AUGUACAU CUGAUGAG GNNNNNNNNC CGAA AUAGACUG	5772
932	UAUCAUGUA CAUAGUUG	2344	CAACUAUG CUGAUGAG GNNNNNNNNC CGAA ACAUGAUA	6499
936	AUGUACAUA GUUGUGGU	2345	ACCACAAC CUGAUGAG GNNNNNNNNC CGAA AUGUACAU	6500
939	UACAUAGUU GUGGUUGU	2346	ACAACCAC CUGAUGAG GNNNNNNNNC CGAA ACUAUGUA	6501
945	GUUGUGGUU GUAGGAUA	2347	UAUCCUAC CUGAUGAG GNNNNNNNNC CGAA ACCACAAC	6502
948	GUGGUUGUA GGAUAUAG	2348	CUAUAUCC CUGAUGAG GNNNNNNNNC CGAA ACAACCAC	6503
953	UGUAGGAUA UAGGAUUU	2349	AAAUCCUA CUGAUGAG GNNNNNNNNC CGAA AUCCUACA	6504
955	UAGGAUAUA GGAUUUAU	2350	AUAAAUCC CUGAUGAG GNNNNNNNNC CGAA AUAUCCUA	6505
960	UAUAGGAUU UAUGAUGU	1626	ACAUCAUA CUGAUGAG GNNNNNNNNC CGAA AUCCUAUA	5782
961	AUAGGAUUU AUGAUGUG	1627	CACAUCAU CUGAUGAG GNNNNNNNNC CGAA AAUCCUAU	5783
962	UAGGAUUUA UGAUGUGA	2351	UCACAUCA CUGAUGAG GNNNNNNNNC CGAA AAAUCCUA	6506
972	GAUGUGAUU CUGAGCCC	2352	GGGCUCAG CUGAUGAG GNNNNNNNNC CGAA AUCACAUC	6507
973	AUGUGAUUC UGAGCCCC	2353	GGGGCUCA CUGAUGAG GNNNNNNNNC CGAA AAUCACAU	6508
993	CAUGAAAUU GAGCUAUC	2354	GAUAGCUC CUGAUGAG GNNNNNNNNC CGAA AUUUCAUG	6509
999	AUUGAGCUA UCUGCCGG	2355	CCGGCAGA CUGAUGAG GNNNNNNNNC CGAA AGCUCAAU	6510
1001	UGAGCUAUC UGCCGGAG	2356	CUCCGGCA CUGAUGAG GNNNNNNNNC CGAA AUAGCUCA	6511
1017	GAAAAACUU GUCUUAAA	2357	UUUAAGAC CUGAUGAG GNNNNNNNNC CGAA AGUUUUUC	6512
1020	AAACUUGUC UUAAAUUG	2358	CAAUUUAA CUGAUGAG GNNNNNNNNC CGAA ACAAGUUU	6513
1022	ACUUGUCUU AAAUUGUA	2359	UACAAUUU CUGAUGAG GNNNNNNNNC CGAA AGACAAGU	6514
1023	CUUGUCUUA AAUUGUAC	1641	GUACAAUU CUGAUGAG GNNNNNNNNC CGAA AAGACAAG	5797
1027	UCUUAAAUU GUACAGCG	2360	CGCUGUAC CUGAUGAG GNNNNNNNNC CGAA AUUUAAGA	6515
1030	UAAAUUGUA CAGCGAGA	2361	UCUCGCUG CUGAUGAG GNNNNNNNNC CGAA ACAAUUUA	6516
1047	ACAGAGCUC AAUGUGGG	2362	CCCACAUU CUGAUGAG GNNNNNNNNC CGAA AGCUCUGU	6517
1059	GUGGGGCUU GAUUUCAC	2363	GUGAAAUC CUGAUGAG GNNNNNNNNC CGAA AGCCCCAC	6518
1063	GGCUUGAUU UCACCUGG	2364	CCAGGUGA CUGAUGAG GNNNNNNNNC CGAA AUCAAGCC	6519
1064	GCUUGAUUU CACCUGGC	2365	GCCAGGUG CUGAUGAG GNNNNNNNNC CGAA AAUCAAGC	6520
1065	CUUGAUUUC ACCUGGCA	2366	UGCCAGGU CUGAUGAG GNNNNNNNNC CGAA AAAUCAAG	6521
1076	CUGGCACUC UCCACCUU	2367	AAGGUGGA CUGAUGAG GNNNNNNNNC CGAA AGUGCCAG	6522
1078	GGCACUCUC CACCUUCA	2368	UGAAGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGUGCC	6523
1084	CUCCACCUU CAAAGUCU	2369	AGACUUUG CUGAUGAG GNNNNNNNNC CGAA AGGUGGAG	6524
1085	UCCACCUUC AAAGUCUC	2370	GAGACUUU CUGAUGAG GNNNNNNNNC CGAA AAGGUGGA	6525
1091	UUCAAAGUC UCAUCAUA	2371	UAUGAUGA CUGAUGAG GNNNNNNNNC CGAA ACUUUGAA	6526
1093	CAAAGUCUC AUCAUAAG	2372	CUUAUGAU CUGAUGAG GNNNNNNNNC CGAA AGACUUUG	6527
1096	AGUCUCAUC AUAAGAAG	2373	CUUCUUAU CUGAUGAG GNNNNNNNNC CGAA AUGAGACU	6528
1099	CUCAUCAUA AGAAGAUU	2374	AAUCUUCU CUGAUGAG GNNNNNNNNC CGAA AUGAUGAG	6529
1107	AAGAAGAUU GUAAACCG	2375	CGGUUUAC CUGAUGAG GNNNNNNNNC CGAA AUCUUCUU	6530
1110	AAGAUUGUA AACCGGGA	2376	UCCCGGUU CUGAUGAG GNNNNNNNNC CGAA ACAAUCUU	6531
1130	GAAACCCUU UCCUGGGA	2377	UCCCAGGA CUGAUGAG GNNNNNNNNC CGAA AGGGUUUC	6532
1131	AAACCCUUU CCUGGGAC	2378	GUCCCAGG CUGAUGAG GNNNNNNNNC CGAA AAGGGUUU	6533
1132	AACCCUUUC CUGGGACU	2379	AGUCCCAG CUGAUGAG GNNNNNNNNC CGAA AAAGGGUU	6534
1154	GAAGAUGUU UUUGAGCA	2380	UGCUCAAA CUGAUGAG GNNNNNNNNC CGAA ACAUCUUC	6535
1155	AAGAUGUUU UUGAGCAC	2381	GUGCUCAA CUGAUGAG GNNNNNNNNC CGAA AACAUCUU	6536
1156	AGAUGUUUU UGAGCACC	2382	GGUGCUCA CUGAUGAG GNNNNNNNNC CGAA AAACAUCU	6537
1157	GAUGUUUUU GAGCACCU	2383	AGGUGCUC CUGAUGAG GNNNNNNNNC CGAA AAAACAUC	6538
1166	GAGCACCUU GACAAUAG	2384	CUAUUGUC CUGAUGAG GNNNNNNNNC CGAA AGGUGCUC	6539
1173	UUGACAAUA GAAAGUGU	2385	ACACUUUC CUGAUGAG GNNNNNNNNC CGAA AUUGUCAA	6540
1205	AGGGGAAUA CACCUGUG	2386	CACAGGUG CUGAUGAG GNNNNNNNNC CGAA AUUCCCCU	6541
1215	ACCUGUGUA GCGUCCAG	2387	CUGGACGC CUGAUGAG GNNNNNNNNC CGAA ACACAGGU	6542
1220	UGUAGCGUC CAGUGGAC	2388	GUCCACUG CUGAUGAG GNNNNNNNNC CGAA ACGCUACA	6543
1236	CGGAUGAUC AAGAGAAA	2389	UUUCUCUU CUGAUGAG GNNNNNNNNC CGAA AUCAUCCG	6544
1246	AGAGAAAUA GAACAUUU	2390	AAAUGUUC CUGAUGAG GNNNNNNNNC CGAA AUUUCUCU	6545
1253	UAGAACAUU UGUCCGAG	2391	CUCGGACA CUGAUGAG GNNNNNNNNC CGAA AUGUUCUA	6546
1254	AGAACAUUU GUCCGAGU	2392	ACUCGGAC CUGAUGAG GNNNNNNNNC CGAA AAUGUUCU	6547
1257	ACAUUUGUC CGAGUUCA	2393	UGAACUCG CUGAUGAG GNNNNNNNNC CGAA ACAAAUGU	6548
1263	GUCCGAGUU CACACAAA	2394	UUUGUGUG CUGAUGAG GNNNNNNNNC CGAA ACUCGGAC	6549
1264	UCCGAGUUC ACACAAAG	2395	CUUUGUGU CUGAUGAG GNNNNNNNNC CGAA AACUCGGA	6550
1276	CAAAGCCUU UUAUUGCU	2396	AGCAAUAA CUGAUGAG GNNNNNNNNC CGAA AGGCUUUG	6551
1277	AAAGCCUUU UAUUGCUU	2397	AAGCAAUA CUGAUGAG GNNNNNNNNC CGAA AAGGCUUU	6552
1278	AAGCCUUUU AUUGCUUU	2398	AAAGCAAU CUGAUGAG GNNNNNNNNC CGAA AAAGGCUU	6553
1279	AGCCUUUUA UUGCUUUC	2399	GAAAGCAA CUGAUGAG GNNNNNNNNC CGAA AAAAGGCU	6554
1281	CCUUUUAUU GCUUUCGG	2400	CCGAAAGC CUGAUGAG GNNNNNNNNC CGAA AUAAAAGG	6555
1285	UUAUUGCUU UCGGUAGU	2401	ACUACCGA CUGAUGAG GNNNNNNNNC CGAA AGCAAUAA	6556
1286	UAUUGCUUU CGGUAGUG	2402	CACUACCG CUGAUGAG GNNNNNNNNC CGAA AAGCAAUA	6557
1287	AUUGCUUUC GGUAGUGG	2403	CCACUACC CUGAUGAG GNNNNNNNNC CGAA AAAGCAAU	6558
1291	CUUUCGGUA GUGGGAUG	2404	CAUCCCAC CUGAUGAG GNNNNNNNNC CGAA ACCGAAAG	6559
1304	GAUGAAAUC UUUGGUGG	2405	CCACCAAA CUGAUGAG GNNNNNNNNC CGAA AUUUCAUC	6560
1306	UGAAAUCUU UGGUGGAA	2406	UUCCACCA CUGAUGAG GNNNNNNNNC CGAA AGAUUUCA	6561
1307	GAAAUCUUU GGUGGAAG	2407	CUUCCACC CUGAUGAG GNNNNNNNNC CGAA AAGAUUUC	6562
1330	UGGGCAGUC AAGUCCGA	2408	UCGGACUU CUGAUGAG GNNNNNNNNC CGAA ACUGCCCA	6563
1335	AGUCAAGUC CGAAUCCC	2409	GGGAUUCG CUGAUGAG GNNNNNNNNC CGAA ACUUGACU	6564
1341	GUCCGAAUC CCUGUGAA	2410	UUCACAGG CUGAUGAG GNNNNNNNNC CGAA AUUCGGAC	6565
1352	UGUGAAGUA UCUCAGUU	2411	AACUGAGA CUGAUGAG GNNNNNNNNC CGAA ACUUCACA	6566
1354	UGAAGUAUC UCAGUUAC	2412	GUAACUGA CUGAUGAG GNNNNNNNNC CGAA AUACUUCA	6567
1356	AAGUAUCUC AGUUACCC	2413	GGGUAACU CUGAUGAG GNNNNNNNNC CGAA AGAUACUU	6568
1360	AUCUCAGUU ACCCAGCU	2414	AGCUGGGU CUGAUGAG GNNNNNNNNC CGAA ACUGAGAU	6569
1361	UCUCAGUUA CCCAGCUC	2415	GAGCUGGG CUGAUGAG GNNNNNNNNC CGAA AACUGAGA	6570
1369	ACCCAGCUC CUGAUAUC	2416	GAUAUCAG CUGAUGAG GNNNNNNNNC CGAA AGCUGGGU	6571
1375	CUCCUGAUA UCAAAUGG	2417	CCAUUUGA CUGAUGAG GNNNNNNNNC CGAA AUCAGGAG	6572
1377	CCUGAUAUC AAAUGGUA	2418	UACCAUUU CUGAUGAG GNNNNNNNNC CGAA AUAUCAGG	6573
1385	CAAAUGGUA CAGAAAUG	2419	CAUUUCUG CUGAUGAG GNNNNNNNNC CGAA ACCAUUUG	6574
1404	AGGCCCAUU GAGUCCAA	2420	UUGGACUC CUGAUGAG GNNNNNNNNC CGAA AUGGGCCU	6575
1409	CAUUGAGUC CAACUACA	2421	UGUAGUUG CUGAUGAG GNNNNNNNNC CGAA ACUCAAUG	6576
1415	GUCCAACUA CACAAUGA	2422	UCAUUGUG CUGAUGAG GNNNNNNNNC CGAA AGUUGGAC	6577
1425	ACAAUGAUU GUUGGCGA	2423	UCGCCAAC CUGAUGAG GNNNNNNNNC CGAA AUCAUUGU	6578
1428	AUGAUUGUU GGCGAUGA	2424	UCAUCGCC CUGAUGAG GNNNNNNNNC CGAA ACAAUCAU	6579
1440	GAUGAACUC ACCAUCAU	2425	AUGAUGGU CUGAUGAG GNNNNNNNNC CGAA AGUUCAUC	6580
1446	CUCACCAUC AUGGAAGU	2426	ACUUCCAU CUGAUGAG GNNNNNNNNC CGAA AUGGUGAG	6581
1478	AGGAAACUA CACGGUCA	2427	UGACCGUG CUGAUGAG GNNNNNNNNC CGAA AGUUUCCU	6582
1485	UACACGGUC AUCCUCAC	2428	GUGAGGAU CUGAUGAG GNNNNNNNNC CGAA ACCGUGUA	6583
1488	ACGGUCAUC CUCACCAA	2429	UUGGUGAG CUGAUGAG GNNNNNNNNC CGAA AUGACCGU	6584
1491	GUCAUCCUC ACCAACCC	2430	GGGUUGGU CUGAUGAG GNNNNNNNNC CGAA AGGAUGAC	6585
1503	AACCCCAUU UCAAUGGA	2431	UCCAUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGGGUU	6586
1504	ACCCCAUUU CAAUGGAG	2432	CUCCAUUG CUGAUGAG GNNNNNNNNC CGAA AAUGGGGU	6587
1505	CCCCAUUUC AAUGGAGA	2433	UCUCCAUU CUGAUGAG GNNNNNNNNC CGAA AAAUGGGG	6588
1530	CACAUGGUC UCUCUGGU	2434	ACCAGAGA CUGAUGAG GNNNNNNNNC CGAA ACCAUGUG	6589
1532	CAUGGUCUC UCUGGUUG	2435	CAACCAGA CUGAUGAG GNNNNNNNNC CGAA AGACCAUG	6590
1534	UGGUCUCUC UGGUUGUG	1714	CACAACCA CUGAUGAG GNNNNNNNNC CGAA AGAGACCA	5870
1539	UCUCUGGUU GUGAAUGU	2436	ACAUUCAC CUGAUGAG GNNNNNNNNC CGAA ACCAGAGA	6591
1548	GUGAAUGUC CCACCCCA	2437	UGGGGUGG CUGAUGAG GNNNNNNNNC CGAA ACAUUCAC	6592
1560	CCCCAGAUC GGUGAGAA	2438	UUCUCACC CUGAUGAG GNNNNNNNNC CGAA AUCUGGGG	5874
1574	GAAAGCCUU GAUCUCGC	2439	GCGAGAUC CUGAUGAG GNNNNNNNNC CGAA AGGCUUUC	6593
1578	GCCUUGAUC UCGCCUAU	2440	AUAGGCGA CUGAUGAG GNNNNNNNNC CGAA AUCAAGGC	6594
1580	CUUGAUCUC GCCUAUGG	2441	CCAUAGGC CUGAUGAG GNNNNNNNNC CGAA AGAUCAAG	6595
1585	UCUCGCCUA UGGAUUCC	2442	GGAAUCCA CUGAUGAG GNNNNNNNNC CGAA AGGCGAGA	6596
1591	CUAUGGAUU CCUACCAG	2443	CUGGUAGG CUGAUGAG GNNNNNNNNC CGAA AUCCAUAG	6597
1592	UAUGGAUUC CUACCAGU	2444	ACUGGUAG CUGAUGAG GNNNNNNNNC CGAA AAUCCAUA	6598
1595	GGAUUCCUA CCAGUAUG	2445	CAUACUGG CUGAUGAG GNNNNNNNNC CGAA AGGAAUCC	6599
1601	CUACCAGUA UGGGACCA	2446	UGGUCCCA CUGAUGAG GNNNNNNNNC CGAA ACUGGUAG	6600
1619	GCAGACAUU GACAUGCA	2447	UGCAUGUC CUGAUGAG GNNNNNNNNC CGAA AUGUCUGC	6601
1632	UGCACAGUC UACGCCAA	2448	UUGGCGUA CUGAUGAG GNNNNNNNNC CGAA ACUGUGCA	6602
1634	CACAGUCUA CGCCAACC	2449	GGUUGGCG CUGAUGAG GNNNNNNNNC CGAA AGACUGUG	6603
1645	CCAACCCUC CCCUGCAC	2450	GUGCAGGG CUGAUGAG GNNNNNNNNC CGAA AGGGUUGG	6604
1659	CACCACAUC CAGUGGUA	2451	UACCACUG CUGAUGAG GNNNNNNNNC CGAA AUGUGGUG	6605
1667	CCAGUGGUA CUGGCAGC	2452	GCUGCCAG CUGAUGAG GNNNNNNNNC CGAA ACCACUGG	6606
1677	UGGCAGCUA GAAGAAGC	2453	GCUUCUUC CUGAUGAG GNNNNNNNNC CGAA AGCUGCCA	6607
1691	AGCCUGCUC CUACAGAC	2454	GUCUGUAG CUGAUGAG GNNNNNNNNC CGAA AGCAGGCU	6608
1694	CUGCUCCUA CAGACCCG	2455	CGGGUCUG CUGAUGAG GNNNNNNNNC CGAA AGGAGCAG	6609
1718	AAGCCCGUA UGCUUGUA	2456	UACAAGCA CUGAUGAG GNNNNNNNNC CGAA ACGGGCUU	6610
1723	CGUAUGCUU GUAAAGAA	2457	UUCUUUAC CUGAUGAG GNNNNNNNNC CGAA AGCAUACG	6611
1726	AUGCUUGUA AAGAAUGG	2458	CCAUUCUU CUGAUGAG GNNNNNNNNC CGAA ACAAGCAU	6612
1750	UGGAGGAUU UCCAGGGG	2459	CCCCUGGA CUGAUGAG GNNNNNNNNC CGAA AUCCUCCA	6613
1751	GGAGGAUUU CCAGGGGG	2460	CCCCCUGG CUGAUGAG GNNNNNNNNC CGAA AAUCCUCC	6614
1752	GAGGAUUUC CAGGGGGG	2461	CCCCCCUG CUGAUGAG GNNNNNNNNC CGAA AAAUCCUC	6615
1770	AACAAGAUC GAAGUCAC	2462	GUGACUUC CUGAUGAG GNNNNNNNNC CGAA AUCUUGUU	6616
1776	AUCGAAGUC ACCAAAAA	2463	UUUUUGGU CUGAUGAG GNNNNNNNNC CGAA ACUUCGAU	6617
1790	AAACCAAUA UGCCCUGA	2464	UCAGGGCA CUGAUGAG GNNNNNNNNC CGAA AUUGGUUU	6618
1800	GCCCUGAUU GAAGGAAA	2465	UUUCCUUC CUGAUGAG GNNNNNNNNC CGAA AUCAGGGC	6619
1821	AAAACUGUA AGUACGCU	2466	AGCGUACU CUGAUGAG GNNNNNNNNC CGAA ACAGUUUU	6620
1825	CUGUAAGUA CGCUGGUC	2467	GACCAGCG CUGAUGAG GNNNNNNNNC CGAA ACUUACAG	6621
1833	ACGCUGGUC AUCCAAGC	2468	GCUUGGAU CUGAUGAG GNNNNNNNNC CGAA ACCAGCGU	6622
1836	CUGGUCAUC CAAGCUGC	2469	GCAGCUUG CUGAUGAG GNNNNNNNNC CGAA AUGACCAG	6623
1853	CAACGUGUC AGCGUUGU	2470	ACAACGCU CUGAUGAG GNNNNNNNNC CGAA ACACGUUG	6624
1859	GUCAGCGUU GUACAAAU	2471	AUUUGUAC CUGAUGAG GNNNNNNNNC CGAA ACGCUGAC	6625
1862	AGCGUUGUA CAAAUGUG	2472	CACAUUUG CUGAUGAG GNNNNNNNNC CGAA ACAACGCU	6626
1878	GAAGCCAUC AACAAAGC	2473	GCUUUGUU CUGAUGAG GNNNNNNNNC CGAA AUGGCUUC	6627
1905	GAGAGGGUC AUCUCCUU	2474	AAGGAGAU CUGAUGAG GNNNNNNNNC CGAA ACCCUCUC	6628
1908	AGGGUCAUC UCCUUCCA	2475	UGGAAGGA CUGAUGAG GNNNNNNNNC CGAA AUGACCCU	6629
1910	GGUCAUCUC CUUCCAUG	2476	CAUGGAAG CUGAUGAG GNNNNNNNNC CGAA AGAUGACC	6630
1913	CAUCUCCUU CCAUGUGA	2477	UCACAUGG CUGAUGAG GNNNNNNNNC CGAA AGGAGAUG	6631
1914	AUCUCCUUC CAUGUGAU	2478	AUCACAUG CUGAUGAG GNNNNNNNNC CGAA AAGGAGAU	6632
1923	CAUGUGAUC AGGGGUCC	2479	GGACCCCU CUGAUGAG GNNNNNNNNC CGAA AUCACAUG	6633
1930	UCAGGGGUC CUGAAAUU	2480	AAUUUCAG CUGAUGAG GNNNNNNNNC CGAA ACCCCUGA	6634
1938	CCUGAAAUU ACUGUGCA	2481	UGCACAGU CUGAUGAG GNNNNNNNNC CGAA AUUUCAGG	6635
1939	CUGAAAUUA CUGUGCAA	2482	UUGCACAG CUGAUGAG GNNNNNNNNC CGAA AAUUUCAG	6636
1982	GAGUGUGUC CCUGUUGU	2483	ACAACAGG CUGAUGAG GNNNNNNNNC CGAA ACACACUC	6637
1988	GUCCCUGUU GUGCACUG	2484	CAGUGCAC CUGAUGAG GNNNNNNNNC CGAA ACAGGGAC	6638
2008	ACAGAAAUA CGUUUGAG	2485	CUCAAACG CUGAUGAG GNNNNNNNNC CGAA AUUUCUGU	6639
2012	AAAUACGUU UGAGAACC	2486	GGUUCUCA CUGAUGAG GNNNNNNNNC CGAA ACGUAUUU	6640
2013	AAUACGUUU GAGAACCU	2487	AGGUUCUC CUGAUGAG GNNNNNNNNC CGAA AACGUAUU	6641
2022	GAGAACCUC ACGUGGUA	2488	UACCACGU CUGAUGAG GNNNNNNNNC CGAA AGGUUCUC	6642
2030	CACGUGGUA CAAGCUUG	2489	CAAGCUUG CUGAUGAG GNNNNNNNNC CGAA ACCACGUG	6643
2037	UACAAGCUU GGCUCACA	2490	UGUGAGCC CUGAUGAG GNNNNNNNNC CGAA AGCUUGUA	6644
2042	GCUUGGCUC ACAGGCAA	2491	UUGCCUGU CUGAUGAG GNNNNNNNNC CGAA AGCCAAGC	6645
2054	GGCAACAUC GGUCCACA	2492	UGUGGACC CUGAUGAG GNNNNNNNNC CGAA AUGUUGCC	6646
2058	ACAUCGGUC CACAUGGG	2493	CCCAUGUG CUGAUGAG GNNNNNNNNC CGAA ACCGAUGU	6647
2072	GGGCGAAUC ACUCACAC	2494	GUGUGAGU CUGAUGAG GNNNNNNNNC CGAA AUUCGCCC	6648
2076	GAAUCACUC ACACCAGU	2495	ACUGGUGU CUGAUGAG GNNNNNNNNC CGAA AGUGAUUC	6649
2085	ACACCAGUU UGCAAGAA	2496	UUCUUGCA CUGAUGAG GNNNNNNNNC CGAA ACUGGUGU	6650
2086	CACCAGUUU GCAAGAAC	2497	GUUCUUGC CUGAUGAG GNNNNNNNNC CGAA AACUGGUG	6651
2096	CAAGAACUU GGAUGCUC	2498	GAGCAUCC CUGAUGAG GNNNNNNNNC CGAA AGUUCUUG	6652
2104	UGGAUGCUC UUUGGAAA	2499	UUUCCAAA CUGAUGAG GNNNNNNNNC CGAA AGCAUCCA	6653
2106	GAUGCUCUU UGGAAACU	2500	AGUUUCCA CUGAUGAG GNNNNNNNNC CGAA AGAGCAUC	6654
2107	AUGCUCUUU GGAAACUG	2401	CAGUUUCC CUGAUGAG GNNNNNNNNC CGAA AAGAGCAU	6655
2129	CACCAUGUU UUCUAACA	2502	UGUUAGAA CUGAUGAG GNNNNNNNNC CGAA ACAUGGUG	6656
2130	ACCAUGUUU UCUAACAG	2503	CUGUUAGA CUGAUGAG GNNNNNNNNC CGAA AACAUGGU	6657
2131	CCAUGUUUU CUAACAGC	2504	GCUGUUAG CUGAUGAG GNNNNNNNNC CGAA AAACAUGG	6658
2132	CAUGUUUUC UAACAGCA	2505	UGCUGUUA CUGAUGAG GNNNNNNNNC CGAA AAAACAUG	6659
2134	UGUUUUCUA ACAGCACA	2506	UGUGCUGU CUGAUGAG GNNNNNNNNC CGAA AGAAAACA	6660
2151	AAUGACAUC UUGAUUGU	2507	ACAAUCAA CUGAUGAG GNNNNNNNNC CGAA AUGUCAUU	6661
2153	UGACAUCUU GAUUGUGG	2508	CCACAAUC CUGAUGAG GNNNNNNNNC CGAA AGAUGUCA	6662
2157	AUCUUGAUU GUGGCAUU	2509	AAUGCCAC CUGAUGAG GNNNNNNNNC CGAA AUCAAGAU	6663
2165	UGUGGCAUU UCAGAAUG	2510	CAUUCUGA CUGAUGAG GNNNNNNNNC CGAA AUGCCACA	6664
2166	GUGGCAUUU CAGAAUGC	2511	GCAUUCUG CUGAUGAG GNNNNNNNNC CGAA AAUGCCAC	6665
2167	UGGCAUUUC AGAAUGCC	2512	GGCAUUCU CUGAUGAG GNNNNNNNNC CGAA AAAUGCCA	6666
2177	GAAUGCCUC UCUGCAGG	2513	CCUGCAGA CUGAUGAG GNNNNNNNNC CGAA AGGCAUUC	6667
2179	AUGCCUCUC UGCAGGAC	2514	GUCCUGCA CUGAUGAG GNNNNNNNNC CGAA AGAGGCAU	6668
2198	AGGCGACUA UGUUUGCU	2515	AGCAAACA CUGAUGAG GNNNNNNNNC CGAA AGUCGCCU	6669
2202	GACUAUGUU UGCUCUGC	2516	GCAGAGCA CUGAUGAG GNNNNNNNNC CGAA ACAUAGUC	6670
2203	ACUAUGUUU GCUCUGCU	2517	AGCAGAGC CUGAUGAG GNNNNNNNNC CGAA AACAUAGU	6671
2207	UGUUUGCUC UGCUCAAG	2518	CUUGAGCA CUGAUGAG GNNNNNNNNC CGAA AGCAAACA	6672
2212	GCUCUGCUC AAGAUAAG	2519	CUUAUCUU CUGAUGAG GNNNNNNNNC CGAA AGCAGAGC	6673
2218	CUCAAGAUA AGAAGACC	2520	GGUCUUCU CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	6674
2239	AAAGACAUU GCCUGGUC	2521	GACCAGGC CUGAUGAG GNNNNNNNNC CGAA AUGUCUUU	6675
2247	UGCCUGGUC AAACAGCU	2522	AGCUGUUU CUGAUGAG GNNNNNNNNC CGAA ACCAGGCA	6676
2256	AAACAGCUC AUCAUCCU	2523	AGGAUGAU CUGAUGAG GNNNNNNNNC CGAA AGCUGUUU	6677
2259	CAGCUCAUC AUCCUAGA	2524	UCUAGGAU CUGAUGAG GNNNNNNNNC CGAA AUGAGCUG	6678
2262	CUCAUCAUC CUAGAGCG	2525	CGCUCUAG CUGAUGAG GNNNNNNNNC CGAA AUGAUGAG	6679
2265	AUCAUCCUA GAGCGCAU	2526	AUGCGCUC CUGAUGAG GNNNNNNNNC CGAA AGGAUGAU	6680
2286	CCCAUGAUC ACCGGAAA	2527	UUUCCGGU CUGAUGAG GNNNNNNNNC CGAA AUCAUGGG	6681
2296	CCGGAAAUC UGGAGAAU	2528	AUUCUCCA CUGAUGAG GNNNNNNNNC CGAA AUUUCCGG	6682
2305	UGGAGAAUC AGACAACA	2529	UGUUGUCU CUGAUGAG GNNNNNNNNC CGAA AUUCUCCA	6683
2319	ACAACCAUU GGCGAGAC	2530	GUCUCGCC CUGAUGAG GNNNNNNNNC CGAA AUGGUUGU	6684
2331	GAGACCAUU GAAGUGAC	2531	GUCACUUC CUGAUGAG GNNNNNNNNC CGAA AUGGUCUC	6685
2341	AAGUGACUU GCCCAGCA	2532	UGCUGGGC CUGAUGAG GNNNNNNNNC CGAA AGUCACUU	6686
2351	CCCAGCAUC UGGAAAUC	2533	GAUUUCCA CUGAUGAG GNNNNNNNNC CGAA AUGCUGGG	6687
2359	CUGGAAAUC CUACCCCA	2534	UGGGGUAG CUGAUGAG GNNNNNNNNC CGAA AUUUCCAG	6688
2362	GAAAUCCUA CCCCACAC	2535	GUGUGGGG CUGAUGAG GNNNNNNNNC CGAA AGGAUUUC	6689
2373	CCACACAUU ACAUGGUU	2536	AACCAUGU CUGAUGAG GNNNNNNNNC CGAA AUGUGUGG	6690
2374	CACACAUUA CAUGGUUC	2537	GAACCAUG CUGAUGAG GNNNNNNNNC CGAA AAUGUGUG	6691
2381	UACAUGGUU CAAAGACA	2538	UGUCUUUG CUGAUGAG GNNNNNNNNC CGAA ACCAUGUA	6692
2382	ACAUGGUUC AAAGACAA	2539	UUGUCUUU CUGAUGAG GNNNNNNNNC CGAA AACCAUGU	6693
2403	ACCCUGGUA GAAGAUUC	2540	GAAUCUUC CUGAUGAG GNNNNNNNNC CGAA ACCAGGGU	6694
2410	UAGAAGAUU CAGGCAUU	2541	AAUGCCUG CUGAUGAG GNNNNNNNNC CGAA AUCUUCUA	6695
2411	AGAAGAUUC AGGCAUUG	2542	CAAUGCCU CUGAUGAG GNNNNNNNNC CGAA AAUCUUCU	6696
2418	UCAGGCAUU GUACUGAG	2543	CUCAGUAC CUGAUGAG GNNNNNNNNC CGAA AUGCCUGA	6697
2421	GGCAUUGUA CUGAGAGA	2544	UCUCUCAG CUGAUGAG GNNNNNNNNC CGAA ACAAUGCC	6698
2449	ACCUGACUA UCCGCAGG	2545	CCUGCGGA CUGAUGAG GNNNNNNNNC CGAA AGUCAGGU	6699
2451	CUGACUAUC CGCAGGGU	2546	ACCCUGCG CUGAUGAG GNNNNNNNNC CGAA AUAGUCAG	6700
2481	GGAGGCCUC UACACCUG	2547	CAGGUGUA CUGAUGAG GNNNNNNNNC CGAA AGGCCUCC	6701
2483	AGGCCUCUA CACCUGCC	1847	GGCAGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGGCCU	6003
2505	UGCAAUGUC CUUGGCUG	2548	CAGCCAAG CUGAUGAG GNNNNNNNNC CGAA ACAUUGCA	6702
2508	AAUGUCCUU GGCUGUGC	2549	GCACAGCC CUGAUGAG GNNNNNNNNC CGAA AGGACAUU	6703
2532	GAGACGCUC UUCAUAAU	2550	AUUAUGAA CUGAUGAG GNNNNNNNNC CGAA AGCGUCUC	6704
2534	GACGCUCUU CAUAAUAG	2551	CUAUUAUG CUGAUGAG GNNNNNNNNC CGAA AGAGCGUC	6705
2535	ACGCUCUUC AUAAUAGA	2552	UCUAUUAU CUGAUGAG GNNNNNNNNC CGAA AAGAGCGU	6706
2538	CUCUUCAUA AUAGAAGG	2553	CCUUCUAU CUGAUGAG GNNNNNNNNC CGAA AUGAAGAG	6707
2541	UUCAUAAUA GAAGGUGC	1857	GCACCUUC CUGAUGAG GNNNNNNNNC CGAA AUUAUGAA	6013
2567	GACCAACUU GGAAGUCA	2554	UGACUUCC CUGAUGAG GNNNNNNNNC CGAA AGUUGGUC	6708
2574	UUGGAAGUC AUUAUCCU	2555	AGGAUAAU CUGAUGAG GNNNNNNNNC CGAA ACUUCCAA	6709
2577	GAAGUCAUU AUCCUCGU	2556	ACGAGGAU CUGAUGAG GNNNNNNNNC CGAA AUGACUUC	6710
2578	AAGUCAUUA UCCUCGUC	2557	GACGAGGA CUGAUGAG GNNNNNNNNC CGAA AAUGACUU	6711
2580	GUCAUUAUC CUCGUCGG	2558	CCGACGAG CUGAUGAG GNNNNNNNNC CGAA AUAAUGAC	6712
2583	AUUAUCCUC GUCGGCAC	2559	GUGCCGAC CUGAUGAG GNNNNNNNNC CGAA AGGAUAAU	6713
2586	AUCCUCGUC GGCACUGC	2560	GCAGUGCC CUGAUGAG GNNNNNNNNC CGAA ACGAGGAU	6714
2601	GCAGUGAUU GCCAUGUU	2561	AACAUGGC CUGAUGAG GNNNNNNNNC CGAA AUCACUGC	6715
2609	UGCCAUGUU CUUCUGGC	1867	GCCAGAAG CUGAUGAG GNNNNNNNNC CGAA ACAUGGCA	6023
2610	GCCAUGUUC UUCUGGCU	1868	AGCCAGAA CUGAUGAG GNNNNNNNNC CGAA AACAUGGC	6024
2612	CAUGUUCUU CUGGCUCC	2562	GGAGCCAG CUGAUGAG GNNNNNNNNC CGAA AGAACAUG	6716
2613	AUGUUCUUC UGGCUCCU	2563	AGGAGCCA CUGAUGAG GNNNNNNNNC CGAA AAGAACAU	6717
2619	UUCUGGCUC CUUCUUGU	2564	ACAAGAAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGAA	6027
2622	UGGCUCCUU CUUGUCAU	2565	AUGACAAG CUGAUGAG GNNNNNNNNC CGAA AGGAGCCA	6718
2623	GGCUCCUUC UUGUCAUU	2566	AAUGACAA CUGAUGAG GNNNNNNNNC CGAA AAGGAGCC	6719
2625	CUCCUUCUU GUCAUUGU	2567	ACAAUGAC CUGAUGAG GNNNNNNNNC CGAA AGAAGGAG	6720
2628	CUUCUUGUC AUUGUCCU	2568	AGGACAAU CUGAUGAG GNNNNNNNNC CGAA ACAAGAAG	6721
2631	CUUGUCAUU GUCCUACG	2569	CGUAGGAC CUGAUGAG GNNNNNNNNC CGAA AUGACAAG	6722
2634	GUCAUUGUC CUACGGAC	2570	GUCCGUAG CUGAUGAG GNNNNNNNNC CGAA ACAAUGAC	6723
2637	AUUGUCCUA CGGACCGU	2571	ACGGUCCG CUGAUGAG GNNNNNNNNC CGAA AGGACAAU	6724
2646	CGGACCGUU AAGCGGGC	2572	GCCCGCUU CUGAUGAG GNNNNNNNNC CGAA ACGGUCCG	6725
2647	GGACCGUUA AGCGGGCC	1880	GGCCCGCU CUGAUGAG GNNNNNNNNC CGAA AACGGUCC	6036
2681	GACAGGCUA CUUGUCUA	2573	UAGACAAG CUGAUGAG GNNNNNNNNC CGAA AGCCUGUC	6726
2684	AGGCUACUU GUCUAUUG	2574	CAAUAGAC CUGAUGAG GNNNNNNNNC CGAA AGUAGCCU	6727
2687	CUACUUGUC UAUUGUCA	2575	UGACAAUA CUGAUGAG GNNNNNNNNC CGAA ACAAGUAG	6728
2689	ACUUGUCUA UUGUCAUG	2576	CAUGACAA CUGAUGAG GNNNNNNNNC CGAA AGACAAGU	6729
2691	UUGUCUAUU GUCAUGGA	2577	UCCAUGAC CUGAUGAG GNNNNNNNNC CCAA AUAGACAA	6730
2694	UCUAUUGUC AUGGAUCC	2578	GGAUCCAU CUGAUGAG GNNNNNNNNC CGAA ACAAUAGA	6731
2701	UCAUGGAUC CAGAUGAA	1886	UUCAUCUG CUGAUGAG GNNNNNNNNC CGAA AUCCAUGA	6042
2711	AGAUGAAUU GCCCUUGG	2579	CCAAGGGC CUGAUGAG GNNNNNNNNC CGAA AUUCAUCU	6732
2717	AUUGCCCUU GGAUGAGC	2580	GCUCAUCC CUGAUGAG GNNNNNNNNC CGAA AGGGCAAU	6733
2738	UGAACGCUU GCCUUAUG	2581	CAUAAGGC CUGAUGAG GNNNNNNNNC CGAA AGCGUUCA	6734
2743	GCUUGCCUU AUGAUGCC	2582	GGCAUCAU CUGAUGAG GNNNNNNNNC CGAA AGGCAAGC	6735
2744	CUUGCCUUA UGAUGCCA	2583	UGGCAUCA CUGAUGAG GNNNNNNNNC CGAA AAGGCAAG	6736
2765	GUGGGAAUU CCCCAGGG	2584	CCCUGGGG CUGAUGAG GNNNNNNNNC CGAA AUUCCCAC	6737
2766	UGGGAAUUC CCCAGGGA	2585	UCCCUGGG CUGAUGAG GNNNNNNNNC CGAA AAUUCCCA	6738
2787	CUGAAACUA GGAAAACC	2586	GGUUUUCC CUGAUGAG GNNNNNNNNC CGAA AGUUUCAG	6739
2797	GAAAACCUC UUGGCCGC	2587	GCGGCCAA CUGAUGAG GNNNNNNNNC CGAA AGGUUUUC	6740
2799	AAACCUCUU GGCCGCGG	2588	CCGCGGCC CUGAUGAG GNNNNNNNNC CGAA AGAGGUUU	6741
2813	CGGUGCCUU CGGCCAAG	2589	CUUGGCCG CUGAUGAG GNNNNNNNNC CGAA AGGCACCG	6742
2814	GGUGCCUUC GGCCAAGU	2590	ACUUGGCC CUGAUGAG GNNNNNNNNC CGAA AAGGCACC	6743
2826	CAAGUGAUU GAGGCAGA	2591	UCUGCCUC CUGAUGAG GNNNNNNNNC CGAA AUCACUUG	6744
2839	CAGACGCUU UUGGAAUU	2592	AAUUCCAA CUGAUGAG GNNNNNNNNC CGAA AGCGUCUG	6745
2840	AGACGCUUU UGGAAUUG	2593	CAAUUCCA CUGAUGAG GNNNNNNNNC CGAA AAGCGUCU	6746
2841	GACGCUUUU GGAAUUGA	2594	UCAAUUCC CUGAUGAG GNNNNNNNNC CGAA AAAGCGUC	6747
2847	UUUGGAAUU GACAAGAC	1903	GUCUUGUC CUGAUGAG GNNNNNNNNC CGAA AUUCCAAA	6059
2863	CAGCGACUU GCAAAACA	2595	UGUUUUGC CUGAUGAG GNNNNNNNNC CGAA AGUCGCUG	6748
2874	AAAACAGUA GCCGUCAA	2596	UUGACGGC CUGAUGAG GNNNNNNNNC CGAA ACUGUUUU	6749
2880	GUAGCCGUC AAGAUGUU	2597	AACAUCUU CUGAUGAG GNNNNNNNNC CGAA ACGGCUAC	6750
2888	CAAGAUGUU GAAAGAAG	2598	CUUCUUUC CUGAUGAG GNNNNNNNNC CGAA ACAUCUUG	6751
2917	GCGAGCAUC GAGCCCUC	2599	GAGGGCUC CUGAUGAG GNNNNNNNNC CGAA AUGCUCGC	6752
2925	CGAGCCCUC AUGUCUGA	2600	UCAGACAU CUGAUGAG GNNNNNNNNC CGAA AGGGCUCG	6753
2930	CCUCAUGUC UGAACUCA	2601	UGAGUUCA CUGAUGAG GNNNNNNNNC CGAA ACAUGAGG	6754
2937	UCUGAACUC AAGAUCCU	1912	AGGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGUUCAGA	6068
2943	CUCAAGAUC CUCAUCCA	2602	UGGAUGAG CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	6755
2946	AAGAUCCUC AUCCACAU	2603	AUGUGGAU CUGAUGAG GNNNNNNNNC CGAA AGGAUCUU	6756
2949	AUCCUCAUC CACAUUGG	2604	CCAAUGUG CUGAUGAG GNNNNNNNNC CGAA AUGAGGAU	6757
2955	AUCCACAUU GGUCACCA	2605	UGGUGACC CUGAUGAG GNNNNNNNNC CGAA AUGUGGAU	6758
2959	ACAUUGGUC ACCAUCUC	2606	GAGAUGGU CUGAUGAG GNNNNNNNNC CGAA ACCAAUGU	6759
2965	GUCACCAUC UCAAUGUG	1920	CACAUUGA CUGAUGAG GNNNNNNNNC CGAA AUGGUGAC	6076
2967	CACCAUCUC AAUGUGGU	1921	ACCACAUU CUGAUGAG GNNNNNNNNC CGAA AGAUGGUG	6077
2982	GUGAACCUC CUAGGCGC	2607	GCGCCUAG CUGAUGAG GNNNNNNNNC CGAA AGGUUCAC	6760
2985	AACCUCCUA GGCGCCUG	2608	CAGGCGCC CUGAUGAG GNNNNNNNNC CGAA AGGAGGUU	6761
3013	GAGGGCCUC UCAUGGUG	2609	CACCAUGA CUGAUGAG GNNNNNNNNC CGAA AGGCCCUC	6762
3015	GGGCCUCUC AUGGUGAU	2610	AUCACCAU CUGAUGAG GNNNNNNNNC CGAA AGAGGCCC	6763
3024	AUGGUGAUU GUGGAAUU	1928	AAUUCCAC CUGAUGAG GNNNNNNNNC CGAA AUCACCAU	6084
3032	UGUGCAAUU CUGCAAGU	2611	ACUUGCAG CUGAUGAG GNNNNNNNNC CGAA AUUCCACA	6764
3033	GUGGAAUUC UGCAAGUU	2612	AACUUGCA CUGAUGAG GNNNNNNNNC CGAA AAUUCCAC	6765
3041	CUGCAACUU UGGAAACC	2613	GGUUUCCA CUGAUGAG GNNNNNNNNC CGAA ACUUGCAG	6766
3042	UGCAAGUUU GGAAACCU	2614	AGGUUUCC CUGAUGAG GNNNNNNNNC CGAA AACUUGCA	6767
3051	GGAAACCUA UCAACUUA	2615	UAAGUUGA CUGAUGAG GNNNNNNNNC CGAA AGGUUUCC	6768
3053	AAACCUAUC AACUUACU	2616	AGUAAGUU CUGAUGAG GNNNNNNNNC CGAA AUAGGUUU	6769
3058	UAUCAACUU ACUUACGG	2617	CCGUAAGU CUGAUGAG GNNNNNNNNC CGAA AGUUGAUA	6770
3059	AUCAACUUA CUUACGGG	2618	CCCGUAAG CUGAUGAG GNNNNNNNNC CGAA AAGUUGAU	6771
3062	AACUUACUU ACGGGGCA	2619	UGCCCCGU CUGAUGAG GNNNNNNNNC CGAA AGUAACUU	6772
3063	ACUUACUUA CGGGGCAA	2620	UUGCCCCG CUGAUGAG GNNNNNNNNC CGAA AAGUAAGU	6773
3083	AAAUGAAUU UGUUCCCU	2621	AGGGAACA CUGAUGAG GNNNNNNNNC CGAA AUUCAUUU	6774
3084	AAUGAAUUU GUUCCCUA	2622	UAGGGAAC CUGAUGAG GNNNNNNNNC CGAA AAUUCAUU	6775
3087	GAAUUUGUU CCCUAUAA	2623	UUAUAGGG CUGAUGAG GNNNNNNNNC CGAA ACAAAUUC	6776
3088	AAUUUGUUC CCUAUAAG	2624	CUUAUAGG CUGAUGAG GNNNNNNNNC CGAA AACAAAUU	6777
3092	UGUUCCCUA UAAGAGCA	2625	UGCUCUUA CUGAUGAG GNNNNNNNNC CGAA AGGGAACA	6778
3094	UUCCCUAUA AGAGCAAA	2626	UUUGCUCU CUGAUGAG GNNNNNNNNC CGAA AUAGGGAA	6779
3113	GGCACGCUU CCGCCAGG	2627	CCUGGCGG CUGAUGAG GNNNNNNNNC CGAA AGCGUGCC	6780
3114	GCACGCUUC CGCCAGGG	2628	CCCUGGCG CUGAUGAG GNNNNNNNNC CGAA AAGCGUGC	6781
3131	CAAGGACUA CGUUGGGG	2629	CCCCAACG CUGAUGAG GNNNNNNNNC CGAA AGUCCUUG	6782
3135	GACUACGUU GGGGAGCU	2630	AGCUCCCC CUGAUGAG GNNNNNNNNC CGAA ACGUAGUC	6783
3144	GGGGAGCUC UCCGUGGA	2631	UCCACGGA CUGAUGAG GNNNNNNNNC CGAA AGCUCCCC	6784
3146	GGAGCUCUC CGUGGAUC	2632	GAUCCACG CUGAUGAG GNNNNNNNNC CGAA AGAGCUCC	6785
3154	CCGUGGAUC UGAAAAGA	2633	UCUUUUCA CUGAUGAG GNNNNNNNNC CGAA AUCCACGG	6786
3167	AAGACGCUU GGACAGCA	2634	UGCUGUCC CUGAUGAG GNNNNNNNNC CGAA AGCGUCUU	6787
3177	GACAGCAUC ACCAGCAG	2635	CUGCUGGU CUGAUGAG GNNNNNNNNC CGAA AUGCUGUC	6788
3194	CCAGAGCUC UGCCAGCU	2636	AGCUGGCA CUGAUGAG GNNNNNNNNC CGAA AGCUCUGG	6789
3203	UGCCAGCUC AGGCUUUG	2637	CAAAGCCU CUGAUGAG GNNNNNNNNC CGAA AGCUGGCA	6790
3209	CUCAGGCUU UCUUGAGG	2638	CCUCAACA CUGAUGAG GNNNNNNNNC CGAA AGCCUGAG	6791
3210	UCAGGCUUU GUUGAGGA	2639	UCCUCAAC CUGAUGAG GNNNNNNNNC CGAA AAGCCUGA	6792
3213	GGCUUUGUU GAGGAGAA	2640	UUCUCCUC CUGAUGAG GNNNNNNNNC CGAA ACAAAGCC	6793
3224	GGAGAAAUC GCUCAGUG	2641	CACUGAGC CUGAUGAG GNNNNNNNNC CGAA AUUUCUCC	6794
3228	AAAUCGCUC AGUGAUGU	2642	ACAUCACU CUGAUGAG GNNNNNNNNC CGAA AGCGAUUU	6795
3237	AGUGAUGUA GAGGAAGA	2643	UCUUCCUC CUGAUGAG GNNNNNNNNC CGAA ACAUCACU	4658
3253	AAGAAGCUU CUGAAGAA	2644	UUCUUCAG CUGAUGAG GNNNNNNNNC CGAA AGCUUCUU	6796
3254	AGAAGCUUC UGAAGAAC	2645	GUUCUUCA CUGAUGAG GNNNNNNNNC CGAA AAGCUUCU	6797
3266	AGAACUGUA CAAGGACU	2646	AGUCCUUG CUGAUGAG GNNNNNNNNC CGAA ACAGUUCU	6798
3275	CAAGGACUU CCUGACCU	2647	AGGUCAGG CUGAUGAG GNNNNNNNNC CGAA AGUCCUUG	6799
3276	AAGGACUUC CUGACCUU	1962	AAGGUCAG CUGAUGAG GNNNNNNNNC CGAA AAGUCCUU	6118
3284	CCUGACCUU GGAGCAUC	1963	GAUGCUCC CUGAUGAG GNNNNNNNNC CGAA AGGUCAGG	6119
3292	UGGAGCAUC UCAUCUGU	1964	ACAGAUGA CUGAUGAG GNNNNNNNNC CGAA AUGCUCCA	6120
3294	GAGCAUCUC AUCUGUUA	1965	UAACAGAU CUGAUGAG GNNNNNNNNC CGAA AGAUGCUC	6121
3297	CAUCUCAUC UGUUACAG	1966	CUGUAACA CUGAUGAG GNNNNNNNNC CGAA AUGAGAUG	6122
3301	UCAUCUGUU ACAGCUUC	1967	GAAGCUGU CUGAUGAG GNNNNNNNNC CGAA ACAGAUGA	6123
3302	CAUCUGUUA CAGCUUCC	1968	GGAAGCUG CUGAUGAG GNNNNNNNNC CGAA AACAGAUG	6124
3308	UUACAGCUU CCAAGUGG	1969	CCACUUGG CUGAUGAG GNNNNNNNNC CGAA AGCUGUAA	6125
3309	UACAGCUUC CAAGUGGC	1970	GCCACUUG CUGAUGAG GNNNNNNNNC CGAA AAGCUGUA	6126
3319	AAGUGGCUA AGGGCAUG	1971	CAUGCCCU CUGAUGAG GNNNNNNNNC CGAA AGCCACUU	6127
3332	CAUGGAGUU CUUGGCAU	1972	AUGCCAAG CUGAUGAG GNNNNNNNNC CGAA ACUCCAUG	6128
3333	AUGGAGUUC UUGGCAUC	1973	GAUGCCAA CUGAUGAG GNNNNNNNNC CGAA AACUCCAU	6129
3335	GGAGUUCUU GGCAUCAA	2648	UUGAUGCC CUGAUGAG GNNNNNNNNC CGAA AGAACUCC	6800
3341	CUUGGCAUC AAGGAAGU	2649	ACUUCCUU CUGAUGAG GNNNNNNNNC CGAA AUGCCAAG	6801
3352	GGAAGUGUA UCCACAGG	2650	CCUGUGGA CUGAUGAG GNNNNNNNNC CGAA ACACUUCC	6802
3354	AAGUGUAUC CACAGGGA	1977	UCCCUGUG CUGAUGAG GNNNNNNNNC CGAA AUACACUU	6133
3381	CGAAACAUU CUCCUAUC	2651	GAUAGGAG CUGAUGAG GNNNNNNNNC CGAA AUGUUUCG	6803
3382	GAAACAUUC UCCUAUCG	2652	CGAUAGGA CUGAUGAG GNNNNNNNNC CGAA AAUGUUUC	6804
3384	AACAUUCUC CUAUCGGA	2653	UCCGAUAG CUGAUGAG GNNNNNNNNC CGAA AGAAUGUU	6805
3387	AUUCUCCUA UCGGAGAA	2654	UUCUCCGA CUGAUGAG GNNNNNNNNC CGAA AGGAGAAU	6806
3389	UCUCCUAUC GGAGAAGA	2655	UCUUCUCC CUGAUGAG GNNNNNNNNC CGAA AUAGGAGA	6807
3405	AAUGUGGUU AAGAUCUG	2656	CAGAUCUU CUGAUGAG GNNNNNNNNC CGAA ACCACAUU	6808
3406	AUGUGGUUA AGAUCUGU	2657	ACAGAUCU CUGAUGAG GNNNNNNNNC CGAA AACCACAU	6809
3411	GUUAAGAUC UGUGACUU	2658	AAGUCACA CUGAUGAG GNNNNNNNNC CGAA AUCUUAAC	6810
3419	CUGUGACUU CGGCUUGG	2659	CCAAGCCG CUGAUGAG GNNNNNNNNC CGAA AGUCACAG	6811
3420	UGUGACUUC GGCUUGGC	2660	GCCAAGCC CUGAUGAG GNNNNNNNNC CGAA AAGUCACA	6144
3425	CUUCGGCUU GGCCCGGG	2661	CCCGGGCC CUGAUGAG GNNNNNNNNC CGAA AGCCGAAG	6812
3438	CGGGACAUU UAUAAAGA	2662	UCUUUAUA CUGAUGAG GNNNNNNNNC CGAA AUGUCCCG	6813
3439	GGGACAUUU AUAAAGAC	2663	GUCUUUAU CUGAUGAG GNNNNNNNNC CGAA AAUGUCCC	6814
3440	GGACAUUUA UAAAGACC	2664	GGUCUUUA CUGAUGAG GNNNNNNNNC CGAA AAAUGUCC	6815
3442	ACAUUUAUA AAGACCCG	2665	CGGGUCUU CUGAUGAG GNNNNNNNNC CGAA AUAAAUGU	6816
3454	ACCCGGAUU AUGUCAGA	2666	UCUGACAU CUGAUGAG GNNNNNNNNC CGAA AUCCGGGU	6817
3455	CCCGGAUUA UGUCAGAA	2667	UUCUGACA CUGAUGAG GNNNNNNNNC CGAA AAUCCGGG	6818
3459	GAUUAUGUC AGAAAAGG	1998	CCUUUUCU CUGAUGAG GNNNNNNNNC CGAA ACAUAAUC	6154
3480	GCCCGACUC CCUUUGAA	2668	UUCAAAGG CUGAUGAG GNNNNNNNNC CGAA AGUCGGGC	6819
3484	GACUCCCUU UGAAGUGG	2669	CCACUUCA CUGAUGAG GNNNNNNNNC CGAA AGGGAGUC	6820
3485	ACUCCCUUU GAAGUGGA	2670	UCCACUUC CUGAUGAG GNNNNNNNNC CGAA AAGGGAGU	6821
3510	GAAACCAUU UUUGACAG	2671	CUGUCAAA CUGAUGAG GNNNNNNNNC CGAA AUGGUUUC	6822
3511	AAACCAUUU UUGACAGA	2672	UCUGUCAA CUGAUGAG GNNNNNNNNC CGAA AAUGGUUU	6823
3512	AACCAUUUU UGACAGAG	2673	CUCUGUCA CUGAUGAG GNNNNNNNNC CGAA AAAUGGUU	6824
3513	ACCAUUUUU GACAGAGU	2674	ACUCUGUC CUGAUGAG GNNNNNNNNC CGAA AAAAUGGU	6825
3522	GACAGAGUA UACACAAU	2675	AUUGUGUA CUGAUGAG GNNNNNNNNC CGAA ACUCUGUC	6826
3524	CAGAGUAUA CACAAUUC	2676	GAAUUGUG CUGAUGAG GNNNNNNNNC CGAA AUACUCUG	6827
3531	UACACAAUU CAGAGCGA	2677	UCGCUCUG CUGAUGAG GNNNNNNNNC CGAA AUUGUGUA	6828
3532	ACACAAUUC AGAGCGAU	2678	AUCGCUCU CUGAUGAG GNNNNNNNNC CGAA AAUUGUGU	6829
3548	UGUGUGGUC UUUCGGUG	2679	CACCGAAA CUGAUGAG GNNNNNNNNC CGAA ACCACACA	6830
3550	UGUGGUCUU UCGGUGUG	2680	CACACCGA CUGAUGAG GNNNNNNNNC CGAA AGACCACA	6831
3551	GUGGUCUUU CGGUGUGU	2681	ACACACCG CUGAUGAG GNNNNNNNNC CGAA AAGACCAC	6832
3552	UGGUCUUUC GGUGUGUU	2682	AACACACC CUGAUGAG GNNNNNNNNC CGAA AAAGACCA	6833
3560	CGGUGUGUU GCUCUGGG	2683	CCCAGAGC CUGAUGAG GNNNNNNNNC CGAA ACACACCG	6834
3564	GUGUUGCUC UGGGAAAU	2684	AUUUCCCA CUGAUGAG GNNNNNNNNC CGAA AGCAACAC	6835
3573	UGGGAAAUA UUUUCCUU	2017	AAGGAAAA CUGAUGAG GNNNNNNNNC CGAA AUUUCCCA	6173
3575	GGAAAUAUU UUCCUUAG	2018	CUAAGGAA CUGAUGAG GNNNNNNNNC CGAA AUAUUUCC	6174
3576	GAAAUAUUU UCCUUAGG	2019	CCUAAGGA CUGAUGAG GNNNNNNNNC CGAA AAUAUUUC	6175
3577	AAAUAUUUU CCUUAGGU	2020	ACCUAAGG CUGAUGAG GNNNNNNNNC CGAA AAAUAUUU	6176
3578	AAUAUUUUC CUUAGGUG	2021	CACCUAAG CUGAUGAG GNNNNNNNNC CGAA AAAAUAUU	6177
3581	AUUUUCCUU AGGUGCCU	2685	AGGCACCU CUGAUGAG GNNNNNNNNC CGAA AGGAAAAU	6836
3582	UUUUCCUUA GGUGCCUC	2686	GAGGCACC CUGAUGAG GNNNNNNNNC CGAA AAGGAAAA	6837
3590	AGGUGCCUC CCCAUACC	2687	GGUAUGGG CUGAUGAG GNNNNNNNNC CGAA AGGCACCU	6838
3596	CUCCCCAUA CCCUGGGG	2688	CCCCAGGG CUGAUGAG GNNNNNNNNC CGAA AUGGGGAG	6839
3606	CCUGGGGUC AAGAUUGA	2689	UCAAUCUU CUGAUGAG GNNNNNNNNC CGAA ACCCCAGG	6185
3612	GUCAAGAUU GAUGAAGA	2690	UCUUCAUC CUGAUGAG GNNNNNNNNC CGAA AUCUUGAC	6840
3623	UGAAGAAUU UUGUAGGA	2691	UCCUACAA CUGAUGAG GNNNNNNNNC CGAA AUUCUUCA	6841
3624	GAAGAAUUU UGUAGGAG	2692	CUCCUACA CUGAUGAG GNNNNNNNNC CGAA AAUUCUUC	6842
3625	AAGAAUUUU GUAGGAGA	2693	UCUCCUAC CUGAUGAG GNNNNNNNNC CGAA AAAUUCUU	6843
3628	AAUUUUGUA GGAGAUUG	2694	CAAUCUCC CUGAUGAG GNNNNNNNNC CGAA ACAAAAUU	6844
3635	UAGGAGAUU GAAAGAAG	2695	CUUCUUUC CUGAUGAG GNNNNNNNNC CGAA AUCUCCUA	6845
3649	AAGGAACUA GAAUGCGG	2696	CCGCAUUC CUGAUGAG GNNNNNNNNC CGAA AGUUCCUU	6846
3661	UGCGGGCUC CUGACUAC	2697	GUAGUCAG CUGAUGAG GNNNNNNNNC CGAA AGCCCGCA	6847
3668	UCCUGACUA CACUACCC	2698	GGGUAGUG CUGAUGAG GNNNNNNNNC CGAA AGUCAGGA	6848
3673	ACUACACUA CCCCAGAA	2699	UUCUGGGG CUGAUGAG GNNNNNNNNC CGAA AGUGUAGU	6849
3686	AGAAAUGUA CCAGACCA	2041	UGGUCUGG CUGAUGAG GNNNNNNNNC CGAA ACAUUUCU	6197
3734	GAGACCCUC GUUUUCAG	2700	CUGAAAAC CUGAUGAG GNNNNNNNNC CGAA AGGGUCUC	6850
3737	ACCCUCGUU UUCAGAGU	2701	ACUCUGAA CUGAUGAG GNNNNNNNNC CGAA ACGAGGGU	6851
3738	CCCUCGUUU UCAGAGUU	2702	AACUCUGA CUGAUGAG GNNNNNNNNC CGAA AACGAGGG	6852
3739	CCUCGUUUU CAGAGUUG	2703	CAACUCUG CUGAUGAG GNNNNNNNNC CGAA AAACGAGG	6853
3740	CUCGUUUUC AGAGUUGG	2704	CCAACUCU CUGAUGAG GNNNNNNNNC CGAA AAAACGAG	6854
3746	UUCAGAGUU GGUGGAGC	2705	GCUCCACC CUGAUGAG GNNNNNNNNC CGAA ACUCUGAA	6855
3757	UGGAGCAUU UGGGAAAC	2706	GUUUCCCA CUGAUGAG GNNNNNNNNC CGAA AUGCUCCA	6856
3758	GGAGCAUUU GGGAAACC	2707	GGUUUCCC CUGAUGAG GNNNNNNNNC CGAA AAUGCUCC	6857
3768	GGAAACCUC CUGCAAGC	2708	GCUUGCAG CUGAUGAG GNNNNNNNNC CGAA AGGUUUCC	6858
3803	CAAAGACUA UAUUGUUC	2709	GAACAAUA CUGAUGAG GNNNNNNNNC CGAA AGUCUUUG	6859
3805	AAGACUAUA UUGUUCUU	2710	AAGAACAA CUGAUGAG GNNNNNNNNC CGAA AUAGUCUU	6860
3807	GACUAUAUU GUUCUUCC	2711	GGAAGAAC CUGAUGAG GNNNNNNNNC CGAA AUAUAGUC	6861
3810	UAUAUUGUU CUUCCAAU	2712	AUUGGAAG CUGAUGAG GNNNNNNNNC CGAA ACAAUAUA	6862
3811	AUAUUGUUC UUCCAAUG	2713	CAUUGGAA CUGAUGAG GNNNNNNNNC CGAA AACAAUAU	6863
3813	AUUGUUCUU CCAAUGUC	2714	GACAUUGG CUGAUGAG GNNNNNNNNC CGAA AGAACAAU	6864
3814	UUGUUCUUC CAAUGUCA	2715	UGACAUUG CUGAUGAG GNNNNNNNNC CGAA AAGAACAA	6865
3821	UCCAAUGUC AGAGACAC	2716	GUGUCUCU CUGAUGAG GNNNNNNNNC CGAA ACAUUGGA	6866
3847	AAGAGGAUU CUGGACUC	2065	GAGUCCAG CUGAUGAG GNNNNNNNNC CGAA AUCCUCUU	6221
3848	AGAGGAUUC UGGACUCU	2066	AGAGUCCA CUGAUGAG GNNNNNNNNC CGAA AAUCCUCU	6222
3855	UCUGGACUC UCCCUGCC	2717	GGCAGGGA CUGAUGAG GNNNNNNNNC CGAA AGUCCAGA	6867
3857	UGGACUCUC CCUGCCUA	2718	UAGGCAGG CUGAUGAG GNNNNNNNNC CGAA AGAGUCCA	6868
3865	CCCUGCCUA CCUCACCU	2719	AGGUGAGG CUGAUGAG GNNNNNNNNC CGAA AGGCAGGG	6869
3869	GCCUACCUC ACCUGUUU	2071	AAACAGGU CUGAUGAG GNNNNNNNNC CGAA AGGUAGGC	6227
3876	UCACCUGUU UCCUGUAU	2072	AUACAGGA CUGAUGAG GNNNNNNNNC CGAA ACAGGUGA	6228
3877	CACCUGUUU CCUGUAUG	2073	CAUACAGG CUGAUGAG GNNNNNNNNC CGAA AACAGGUG	6229
3878	ACCUGUUUC CUGUAUGG	2074	CCAUACAG CUGAUGAG GNNNNNNNNC CGAA AAACAGGU	6230
3883	UUUCCUGUA UGGAGGAA	2720	UUCCUCCA CUGAUGAG GNNNNNNNNC CGAA ACAGGAAA	6870
3914	CCCCAAAUU CCAUUAUG	2077	CAUAAUGG CUGAUGAG GNNNNNNNNC CGAA AUUUGGGG	6233
3915	CCCAAAUUC CAUUAUGA	2078	UCAUAAUG CUGAUGAG GNNNNNNNNC CGAA AAUUUGGG	6234
3919	AAUUCCAUU AUGACAAC	2079	GUUGUCAU CUGAUGAG GNNNNNNNNC CGAA AUGGAAUU	6235
3920	AUUCCAUUA UGACAACA	2080	UGUUGUCA CUGAUGAG GNNNNNNNNC CGAA AAUGGAAU	6236
3939	GCAGGAAUC AGUCAUUA	2721	UAAUGACU CUGAUGAG GNNNNNNNNC CGAA AUUCCUGC	6871
3943	GAAUCAGUC AUUAUCUC	2722	GAGAUAAU CUGAUGAG GNNNNNNNNC CGAA ACUGAUUC	6872
3946	UCAGUCAUU AUCUCCAG	2723	CUGGAGAU CUGAUGAG GNNNNNNNNC CGAA AUGACUGA	6873
3947	CAGUCAUUA UCUCCAGA	2724	UCUGGAGA CUGAUGAG GNNNNNNNNC CGAA AAUGACUG	6874
3949	GUCAUUAUC UCCAGAAC	2725	GUUCUGGA CUGAUGAG GNNNNNNNNC CGAA AUAAUGAC	6875
3951	CAUUAUCUC CAGAACAG	2726	CUGUUCUG CUGAUGAG GNNNNNNNNC CGAA AGAUAAUG	6876
3961	AGAACAGUA AGCGAAAG	2085	CUUUCGCU CUGAUGAG GNNNNNNNNC CGAA ACUGUUCU	6241
3987	GUGAGUGUA AAAACAUU	2086	AAUGUUUU CUGAUGAG GNNNNNNNNC CGAA ACACUCAC	6242
3995	AAAAACAUU UGAAGAUA	2087	UAUCUUCA CUGAUGAG GNNNNNNNNC CGAA AUGUUUUU	6243
3996	AAAACAUUU GAAGAUAU	2088	AUAUCUUC CUGAUGAG GNNNNNNNNC CGAA AAUGUUUU	6244
4003	UUGAAGAUA UCCCAUUG	2727	CAAUGGGA CUGAUGAG GNNNNNNNNC CGAA AUCUUCAA	6877
4005	GAAGAUAUC CCAUUGGA	2728	UCCAAUGG CUGAUGAG GNNNNNNNNC CGAA AUAUCUUC	6878
4010	UAUCCCAUU GGAGGAAC	2729	GUUCCUCC CUGAUGAG GNNNNNNNNC CGAA AUGGGAUA	6879
4026	CCAGAAGUA AAAGUGAU	2730	AUCACUUU CUGAUGAG GNNNNNNNNC CGAA ACUUCUGG	6880
4035	AAAGUGAUC CCAGAUGA	2731	UCAUCUGG CUGAUGAG GNNNNNNNNC CGAA AUCACUUU	6881
4068	GGGAUGGUC CUUGCAUC	2732	GAUGCAAG CUGAUGAG GNNNNNNNNC CGAA ACCAUCCC	6882
4071	AUGGUCCUU GCAUCAGA	2733	UCUGAUGC CUGAUGAG GNNNNNNNNC CGAA AGGACCAU	6883
4076	CCUUGCAUC AGAAGAGC	2734	GCUCUUCU CUGAUGAG GNNNNNNNNC CGAA AUGCAAGG	6884
4093	UGAAAACUC UGGAAGAC	2735	GUCUUCCA CUGAUGAG GNNNNNNNNC CGAA AGUUUUCA	6257
4112	GAACAAAUU AUCUCCAU	2736	AUGGAGAU CUGAUGAG GNNNNNNNNC CGAA AUUUGUUC	6885
4113	AACAAAUUA UCUCCAUC	2737	GAUGGAGA CUGAUGAG GNNNNNNNNC CGAA AAUUUGUU	6886
4115	CAAAUUAUC UCCAUCUU	2105	AAGAUGGA CUGAUGAG GNNNNNNNNC CGAA AUAAUUUG	6261
4117	AAUUAUCUC CAUCUUUU	2106	AAAAGAUG CUGAUGAG GNNNNNNNNC CGAA AGAUAAUU	6262
4121	AUCUCCAUC UUUUGGUG	2107	CACCAAAA CUGAUGAG GNNNNNNNNC CGAA AUGGAGAU	6263
4123	CUCCAUCUU UUGGUGGA	2108	UCCACCAA CUGAUGAG GNNNNNNNNC CGAA AGAUGGAG	6264
4124	UCCAUCUUU UGGUGGAA	2109	UUCCACCA CUGAUGAG GNNNNNNNNC CGAA AAGAUGGA	6265
4125	CCAUCUUUU GGUGGAAU	2110	AUUCCACC CUGAUGAG GNNNNNNNNC CGAA AAAGAUGG	6266
4144	UGCCCAGUA AAAGCAGG	2738	CCUGCUUU CUGAUGAG GNNNNNNNNC CGAA ACUGGGCA	6887
4157	CAGGGAGUC UGUGGCCU	2739	AGGCCACA CUGAUGAG GNNNNNNNNC CGAA ACUCCCUG	6888
4166	UGUGGCCUC GGAAGGCU	2740	AGCCUUCC CUGAUGAG GNNNNNNNNC CGAA AGGCCACA	6889
4175	GGAAGGCUC CAACCAGA	2741	UCUGGUUG CUGAUGAG GNNNNNNNNC CGAA AGCCUUCC	6890
4193	CAGUGGCUA CCAGUCUG	2742	CAGACUGG CUGAUGAG GNNNNNNNNC CGAA AGCCACUG	6891
4199	CUACCAGUC UGGGUAUC	2743	GAUACCCA CUGAUGAG GNNNNNNNNC CGAA ACUGGUAG	6892
4205	GUCUGGGUA UCACUCAG	2744	CUGAGUGA CUGAUGAG GNNNNNNNNC CGAA ACCCAGAC	6893
4207	CUGGGUAUC ACUCAGAU	2745	AUCUGAGU CUGAUGAG GNNNNNNNNC CGAA AUACCCAG	6894
4211	GUAUCACUC AGAUGACA	2746	UGUCAUCU CUGAUGAG GNNNNNNNNC CGAA AGUGAUAC	6895
4235	CACCGUGUA CUCCAGCG	2747	CGCUGGAG CUGAUGAG GNNNNNNNNC CGAA ACACGGUG	6896
4238	CGUGUACUC CAGCGACG	2748	CGUCGCUG CUGAUGAG GNNNNNNNNC CGAA AGUACACG	6897
4257	GCAGGACUU UUAAAGAU	2749	AUCUUUAA CUGAUGAG GNNNNNNNNC CGAA AGUCCUGC	6898
4258	CAGGACUUU UAAAGAUG	2750	CAUCUUUA CUGAUGAG GNNNNNNNNC CGAA AAGUCCUG	6899
4259	AGGACUUUU AAAGAUGG	2751	CCAUCUUU CUGAUGAG GNNNNNNNNC CGAA AAAGUCCU	6900
4260	GGACUUUUA AAGAUGGU	2752	ACCAUCUU CUGAUGAG GNNNNNNNNC CGAA AAAAGUCC	6901
4281	GCUGCAGUU CACGCUGA	2753	UCAGCGUG CUGAUGAG GNNNNNNNNC CGAA ACUGCAGC	6902
4282	CUGCAGUUC ACGCUGAC	2754	GUCAGCGU CUGAUGAG GNNNNNNNNC CGAA AACUGCAG	6903
4292	CGCUGACUC AGGGACCA	2755	UGGUCCCU CUGAUGAG GNNNNNNNNC CGAA AGUCAGCG	6904
4311	CUGCAGCUC ACCUCCUG	2756	CAGGAGGU CUGAUGAG GNNNNNNNNC CGAA AGCUGCAG	6905
4316	GCUCACCUC CUGUUUAA	2757	UUAAACAG CUGAUGAG GNNNNNNNNC CGAA AGGUGAGC	6906
4321	CCUCCUGUU UAAAUGGA	2758	UCCAUUUA CUGAUGAG GNNNNNNNNC CGAA ACAGGAGG	6907
4322	CUCCUGUUU AAAUGGAA	2759	UUCCAUUU CUGAUGAG GNNNNNNNNC CGAA AACAGGAG	6908
4323	UCCUGUUUA AAUGGAAG	2760	CUUCCAUU CUGAUGAG GNNNNNNNNC CGAA AAACAGGA	6909
4336	GAAGUGGUC CUGUCCCG	2761	CGGGACAG CUGAUGAG GNNNNNNNNC CGAA ACCACUUC	6910
4341	GGUCCUGUC CCGGCUCC	2762	GGAGCCGG CUGAUGAG GNNNNNNNNC CGAA ACAGGACC	6911
4348	UCCCGGCUC CGCCCCCA	2763	UGGGGGCG CUGAUGAG GNNNNNNNNC CGAA AGCCGGGA	6912
4360	CCCCAACUC CUGGAAAU	2764	AUUUCCAG CUGAUGAG GNNNNNNNNC CGAA AGUUGGGG	6913
4369	CUGGAAAUC ACGAGAGA	2765	UCUCUCGU CUGAUGAG GNNNNNNNNC CGAA AUUUCCAG	6914
4387	GUGCUGCUU AGAUUUUC	2766	GAAAAUCU CUGAUGAG GNNNNNNNNC CGAA AGCAGCAC	6915
4388	UGCUGCUUA GAUUUUCA	2767	UGAAAAUC CUGAUGAG GNNNNNNNNC CGAA AAGCAGCA	6916
4392	GCUUAGAUU UUCAAGUG	2768	CACUUGAA CUGAUGAG GNNNNNNNNC CGAA AUCUAAGC	6917
4393	CUUAGAUUU UCAAGUGU	2769	ACACUUGA CUGAUGAG GNNNNNNNNC CGAA AAUCUAAG	6918
4394	UUAGAUUUU CAAGUGUU	2770	AACACUUG CUGAUGAG GNNNNNNNNC CGAA AAAUCUAA	6919
4395	UAGAUUUUC AAGUGUUG	2771	CAACACUU CUGAUGAG GNNNNNNNNC CGAA AAAAUCUA	6920
4402	UCAAGUGUU GUUCUUUC	2772	GAAAGAAC CUGAUGAG GNNNNNNNNC CGAA ACACUUGA	6921
4405	AGUGUUGUU CUUUCCAC	2146	GUGGAAAG CUGAUGAG GNNNNNNNNC CGAA ACAACACU	6302
4406	GUGUUGUUC UUUCCACC	2147	GGUGGAAA CUGAUGAG GNNNNNNNNC CGAA AACAACAC	6303
4408	GUUGUUCUU UCCACCAC	2773	GUGGUGGA CUGAUGAG GNNNNNNNNC CGAA AGAACAAC	6922
4409	UUGUUCUUU CCACCACC	2774	GGUGGUGG CUGAUGAG GNNNNNNNNC CGAA AAGAACAA	6923
4410	UGUUCUUUC CACCACCC	2775	GGGUGGUG CUGAUGAG GNNNNNNNNC CGAA AAAGAACA	6924
4425	CCGGAAGUA GCCACAUU	2776	AAUGUGGC CUGAUGAG GNNNNNNNNC CGAA ACUUCCGG	6925
4433	AGCCACAUU UGAUUUUC	2777	GAAAAUCA CUGAUGAG GNNNNNNNNC CGAA AUGUGGCU	6926
4434	GCCACAUUU GAUUUUCA	2778	UGAAAAUC CUGAUGAG GNNNNNNNNC CGAA AAUGUGGC	6927
4438	CAUUUGAUU UUCAUUUU	2779	AAAAUGAA CUGAUGAG GNNNNNNNNC CGAA AUCAAAUG	6928
4439	AUUUGAUUU UCAUUUUU	2780	AAAAAUGA CUGAUGAG GNNNNNNNNC CGAA AAUCAAAU	6929
4440	UUUGAUUUU CAUUUUUG	2781	CAAAAAUG CUGAUGAG GNNNNNNNNC CGAA AAAUCAAA	6930
4441	UUGAUUUUC AUUUUUGG	2782	CCAAAAAU CUGAUGAG GNNNNNNNNC CGAA AAAAUCAA	6931
4444	AUUUUCAUU UUUGGAGG	2783	CCUCCAAA CUGAUGAG GNNNNNNNNC CGAA AUGAAAAU	6932
4445	UUUUCAUUU UUGGAGGA	2784	UCCUCCAA CUGAUGAG GNNNNNNNNC CGAA AAUGAAAA	6933
4446	UUUCAUUUU UGGAGGAG	2785	CUCCUCCA CUGAUGAG GNNNNNNNNC CGAA AAAUGAAA	6934
4447	UUCAUUUUU GGAGGAGG	2786	CCUCCUCC CUGAUGAG GNNNNNNNNC CGAA AAAAUGAA	6935
4461	AGGGACCUC AGACUGCA	2787	UGCAGUCU CUGAUGAG GNNNNNNNNC CGAA AGGUCCCU	6936
4477	AAGGAGCUU GUCCUCAG	2788	CUGAGGAC CUGAUGAG GNNNNNNNNC CGAA AGCUCCUU	6937
4480	GAGCUUGUC CUCAGGGC	2789	GCCCUGAG CUGAUGAG GNNNNNNNNC CGAA ACAAGCUC	6938
4483	CUUGUCCUC AGGGCAUU	2790	AAUGCCCU CUGAUGAG GNNNNNNNNC CGAA AGGACAAG	6939
4491	CAGGGCAUU UCCAGAGA	2791	UCUCUGGA CUGAUGAG GNNNNNNNNC CGAA AUGCCCUG	6940
4492	AGGGCAUUU CCAGAGAA	2792	UUCUCUGG CUGAUGAG GNNNNNNNNC CGAA AAUGCCCU	6941
4493	GGGCAUUUC CAGAGAAG	2793	CUUCUCUG CUGAUGAG GNNNNNNNNC CGAA AAAUGCCC	6942
4528	GAAUGUGUU GACUCUAC	2794	GUAGAGUC CUGAUGAG GNNNNNNNNC CGAA ACACAUUC	6943
4530	UGUUGACUC UACUCUCU	2795	AGAGAGUA CUGAUGAG GNNNNNNNNC CGAA AGUCAACA	6944
4532	UUGACUCUA CUCUCUUU	2796	AAAGAGAG CUGAUGAG GNNNNNNNNC CGAA AGAGUCAA	6945
4535	ACUCUACUC UCUUUUCC	2797	GGAAAAGA CUGAUGAG GNNNNNNNNC CGAA AGUAGAGU	6946
4537	UCUACUCUC UUUUCCAU	2798	AUGGAAAA CUGAUGAG GNNNNNNNNC CGAA AGAGUAGA	6947
4539	UACUCUCUU UUCCAUUC	2799	GAAUGGAA CUGAUGAG GNNNNNNNNC CGAA AGAGAGUA	6948
4540	ACUCUCUUU UCCAUUCA	2800	UGAAUGGA CUGAUGAG GNNNNNNNNC CGAA AAGAGAGU	6949
4541	CUCUCUUUU CCAUUCAU	2801	AUGAAUGG CUGAUGAG GNNNNNNNNC CGAA AAAGAGAG	6950
4542	UCUCUUUUC CAUUCAUU	2802	AAUGAAUG CUGAUGAG GNNNNNNNNC CGAA AAAAGAGA	6951
4546	UUUUCCAUU CAUUUAAA	2803	UUUAAAUG CUGAUGAG GNNNNNNNNC CGAA AUGGAAAA	6952
4547	UUUCCAUUC AUUUAAAA	2804	UUUUAAAU CUGAUGAG GNNNNNNNNC CGAA AAUGGAAA	6953
4550	CCAUUCAUU UAAAAGUC	2805	GACUUYUA CUGAUGAG GNNNNNNNNC CGAA AUGAAUGG	6954
4551	CAUUCAUUU AAAAGUCC	2806	GGACUUUU CUGAUGAG GNNNNNNNNC CGAA AAUGAAUG	6955
4552	AUUCAUUUA AAAGUCCU	2807	AGGACUUU CUGAUGAG GNNNNNNNNC CGAA AAAUGAAU	6956
4558	UUAAAAGUC CUAUAUAA	2808	UUAUAUAG CUGAUGAG GNNNNNNNNC CGAA ACUUUUAA	6957
4561	AAAGUCCUA UAUAAUGU	2809	ACAUUAUA CUGAUGAG GNNNNNNNNC CGAA AGGACUUU	6958
4563	AGUCCUAUA UAAUGUGC	2810	GCACAUUA CUGAUGAG GNNNNNNNNC CGAA AUAGGACU	6959
4565	UCCUAUAUA AUGUGCCC	2811	GGGCACAU CUGAUGAG GNNNNNNNNC CGAA AUAUAGGA	6960
4583	GCUGUGGUC UCACUACC	2812	GGUAGUGA CUGAUGAG GNNNNNNNNC CGAA ACCACAGC	6961
4585	UGUGGUCUC ACUACCAG	2813	CUGGUAGU CUGAUGAG GNNNNNNNNC CGAA AGACCACA	6962
4589	GUCUCACUA CCAGUUAA	2814	UUAACUGG CUGAUGAG GNNNNNNNNC CGAA AGUGAGAC	6963
4595	CUACCAGUU AAAGCAAA	2815	UUUGCUUU CUGAUGAG GNNNNNNNNC CGAA ACUGGUAG	6964
4596	UACCAGUUA AAGCAAAA	2816	UUUUGCUU CUGAUGAG GNNNNNNNNC CGAA AACUGGUA	696S
4609	AAAAGACUU UCAAACAC	2817	GUGUUUGA CUGAUGAG GNNNNNNNNC CGAA AGUCUUUU	6966
4610	AAAGACUUU CAAACACG	2818	CGUGUUUG CUGAUGAG GNNNNNNNNC CGAA AAGUCUUU	6967
4611	AAGACUUUC AAACACGU	2819	ACGUGUUU CUGAUGAG GNNNNNNNNC CGAA AAAGUCUU	6968
4625	CGUGGACUC UGUCCUCC	2820	GGAGGACA CUGAUGAG GNNNNNNNNC CGAA AGUCCACG	6969
4629	GACUCUGUC CUCCAAGA	2821	UCUUGGAG CUGAUGAG GNNNNNNNNC CGAA ACAGAGUC	6970
4632	UCUGUCCUC CAAGAAGU	2822	ACUUCUUG CUGAUGAG GNNNNNNNNC CGAA AGGACAGA	6971
4654	CGGCACCUC UGUGAAAC	2823	GUUUCACA CUGAUGAG GNNNNNNNNC CGAA AGGUGCCG	6972
4668	AACUGGAUC GAAUGGGC	2824	GCCCAUUC CUGAUGAG GNNNNNNNNC CGAA AUCCAGUU	6973
4683	GCAAUGCUU UGUGUGUU	2825	AACACACA CUGAUGAG GNNNNNNNNC CGAA AGCAUUGC	6974
4684	CAAUGCUUU GUGUGUUG	2826	CAACACAC CUGAUGAG GNNNNNNNNC CGAA AAGCAUUG	6975
4691	UUGUGUGUU GAGGAUGG	2827	CCAUCCUC CUGAUGAG GNNNNNNNNC CGAA ACACACAA	6976
4709	UGAGAUGUC CCAGGGCC	2828	GGCCCUGG CUGAUGAG GNNNNNNNNC CGAA ACAUCUCA	6977
4722	GGCCGAGUC UGUCUACC	2829	GGUAGACA CUGAUGAG GNNNNNNNNC CGAA ACUCGGCC	6978
4726	GAGUCUGUC UACCUUGG	2830	CCAAGGUA CUGAUGAG GNNNNNNNNC CGAA ACAGACUC	6979
4728	GUCUGUCUA CCUUGGAG	2831	CUCCAAGG CUGAUGAG GNNNNNNNNC CGAA AGACAGAC	6980
4732	GUCUACCUU GGAGGCUU	2832	AAGCCUCC CUGAUGAG GNNNNNNNNC CGAA AGGUAGAC	6981
4740	UGGAGGCUU UGUGGAGG	2833	CCUCCACA CUGAUGAG GNNNNNNNNC CGAA AGCCUCCA	6982
4741	GGAGGCUUU GUGGAGGA	2834	UCCUCCAC CUGAUGAG GNNNNNNNNC CGAA AAGCCUCC	6983
4758	UGCGGGCUA UGAGCCAA	2835	UUGGCUCA CUGAUGAG GNNNNNNNNC CGAA AGCCCGCA	6984
4771	CCAAGUGUU AAGUGUGG	2836	CCACACUU CUGAUGAG GNNNNNNNNC CGAA ACACUUGG	6985
4772	CAAGUGUUA AGUGUGGG	2837	CCCACACU CUGAUGAG GNNNNNNNNC CGAA AACACUUG	6986
4811	GCGCAAGUC GCUCGGAG	2838	CUCCGAGC CUGAUGAG GNNNNNNNNC CGAA ACUUGCGC	6987
4815	AAGUCGCUC GGAGAGCG	2839	CGCUCUCC CUGAUGAG GNNNNNNNNC CGAA AGCGACUU	6988
4826	AGAGCGGUU GGAGCCUG	2840	CAGGCUCC CUGAUGAG GNNNNNNNNC CGAA ACCGCUCU	6989
4844	AGAUGCAUU GUGCUGGC	2841	GCCAGCAC CUGAUGAG GNNNNNNNNC CGAA AUGCAUCU	6990
4854	UGCUGGCUC UGGUGGAG	2842	CUCCACCA CUGAUGAG GNNNNNNNNC CGAA AGCCAGCA	6991
4870	GGUGGGCUU GUGGCCUG	2843	CAGGCCAC CUGAUGAG GNNNNNNNNC CGAA AGCCCACC	6992
4880	UGGCCUGUC AGGAAACG	2844	CGUUUCCU CUGAUGAG GNNNNNNNNC CGAA ACAGGCCA	6993
4908	GGCAGGGUU UGGUUUUG	2845	CAAAACCA CUGAUGAG GNNNNNNNNC CGAA ACCCUGCC	6994
4909	GCAGGGUUU GGUUUUGG	2846	CCAAAACC CUGAUGAG GNNNNNNNNC CGAA AACCCUGC	6995
4913	GGUUUGGUU UUGGAAGG	2847	CCUUCCAA CUGAUGAG GNNNNNNNNC CGAA ACCAAACC	6996
4914	GUUUGGUUU UGGAAGGU	2848	ACCUUCCA CUGAUGAG GNNNNNNNNC CGAA AACCAAAC	6997
4915	UUUGGUUUU GGAAGGUU	2849	AACCUUCC CUGAUGAG GNNNNNNNNC CGAA AAACCAAA	6998
4923	UGGAAGGUU UGCGUGCU	2850	AGCACGCA CUGAUGAG GNNNNNNNNC CGAA ACCUUCCA	6999
4924	GGAAGGUUU GCGUGCUC	2851	GAGCACGC CUGAUGAG GNNNNNNNNC CGAA AACCUUCC	7000
4932	UGCGUGCUC UUCACAGU	2852	ACUGUGAA CUGAUGAG GNNNNNNNNC CGAA AGCACGCA	7001
4934	CGUGCUCUU CACAGUCG	2853	CGACUGUG CUGAUGAG GNNNNNNNNC CGAA AGAGCACG	7002
4935	GUGCUCUUC ACAGUCGG	2854	CCGACUGU CUGAUGAG GNNNNNNNNC CGAA AAGAGCAC	7003
4941	UUCACAGUC GGGUUACA	2855	UGUAACCC CUGAUGAG GNNNNNNNNC CGAA ACUGUGAA	7004
4946	AGUCGGGUU ACAGGCGA	2856	UCGCCUGU CUGAUGAG GNNNNNNNNC CGAA ACCCGACU	7005
4947	GUCGGGUUA CAGGCGAG	2857	CUCGCCUG CUGAUGAG GNNNNNNNNC CGAA AACCCGAC	7006
4957	AGGCGAGUU CCCUGUGG	2858	CCACAGGG CUGAUGAG GNNNNNNNNC CGAA ACUCGCCU	7007
4958	GGCGAGUUC CCUGUGGC	2859	GCCACAGG CUGAUGAG GNNNNNNNNC CGAA AACUCGCC	7008
4969	UGUGGCGUU UCCUACUC	2860	GAGUAGGA CUGAUGAG GNNNNNNNNC CGAA ACGCCACA	7009
4970	GUGGCGUUU CCUACUCC	2861	GGAGUAGG CUGAUGAG GNNNNNNNNC CGAA AACGCCAC	7010
4971	UGGCGUUUC CUACUCCU	2862	AGGAGUAG CUGAUGAG GNNNNNNNNC CGAA AAACGCCA	7011
4974	CGUUUCCUA CUCCUAAU	2863	AUUAGGAG CUGAUGAG GNNNNNNNNC CGAA AGGAAACG	7012
4977	UUCCUACUC CUAAUGAG	2864	CUCAUUAG CUGAUGAG GNNNNNNNNC CGAA AGUAGGAA	7013
4980	CUACUCCUA AUGAGAGU	2865	ACUCUCAU CUGAUGAG GNNNNNNNNC CGAA AGGAGUAG	7014
4989	AUGAGAGUU CCUUCCGG	2866	CCGGAAGG CUGAUGAG GNNNNNNNNC CGAA ACUCUCAU	7015
4990	UGAGAGUUC CUUCCGGA	2867	UCCGGAAG CUGAUGAG GNNNNNNNNC CGAA AACUCUCA	7016
4993	GAGUUCCUU CCGGACUC	2868	GAGUCCGG CUGAUGAG GNNNNNNNNC CGAA AGGAACUC	7017
4994	AGUUCCUUC CGGACUCU	2869	AGAGUCCG CUGAUGAG GNNNNNNNNC CGAA AAGGAACU	7018
5001	UCCGGACUC UUACGUGU	2870	ACACGUAA CUGAUGAG GNNNNNNNNC CGAA AGUCCGGA	7019
5003	CGGACUCUU ACGUGUCU	2871	AGACACGU CUGAUGAG GNNNNNNNNC CGAA AGAGUCCG	7020
5004	GGACUCUUA CGUGUCUC	2872	GAGACACG CUGAUGAG GNNNNNNNNC CGAA AAGAGUCC	7021
5010	UUACGUGUC UCCUGGCC	2873	GGCCAGGA CUGAUGAG GNNNNNNNNC CGAA ACACGUAA	7022
5012	ACGUGUCUC CUGGCCUG	2874	CAGGCCAG CUGAUGAG GNNNNNNNNC CGAA AGACACGU	7023
5046	AUGCAGCUU GCUCCUUC	2875	GAAGGAGC CUGAUGAG GNNNNNNNNC CGAA AGCUGCAU	7024
5050	AGCUUGCUC CUUCCUCA	2876	UGAGGAAG CUGAUGAG GNNNNNNNNC CGAA AGCAAGCU	7025
5053	UUGCUCCUU CCUCAUCU	2877	AGAUGAGG CUGAUGAG GNNNNNNNNC CGAA AGGAGCAA	7026
5054	UGCUCCUUC CUCAUCUC	2878	GAGAUGAG CUGAUGAG GNNNNNNNNC CGAA AAGGAGCA	7027
5057	UCCUUCCUC AUCUCUCA	2879	UGAGAGAU CUGAUGAG GNNNNNNNNC CGAA AGGAAGGA	7028
5060	UUCCUCAUC UCUCAGGC	2880	GCCUGAGA CUGAUGAG GNNNNNNNNC CGAA AUGAGGAA	7029
5062	CCUCAUCUC UCAGGCUG	2881	CAGCCUGA CUGAUGAG GNNNNNNNNC CGAA AGAUGAGG	7030
5064	UCAUCUCUC AGGCUGUG	2882	CACAGCCU CUGAUGAG GNNNNNNNNC CGAA AGAGAUGA	7031
5076	CUGUGCCUU AAUUCAGA	2883	UCUGAAUU CUGAUGAG GNNNNNNNNC CGAA AGGCACAG	7032
5077	UGUGCCUUA AUUCAGAA	2884	UUCUGAAU CUGAUGAG GNNNNNNNNC CGAA AAGGCACA	7033
5080	GCCUUAAUU CAGAACAC	2885	GUGUUCUG CUGAUGAG GNNNNNNNNC CGAA AUUAAGGC	7034
5081	CCUUAAUUC AGAACACC	2886	GGUGUUCU CUGAUGAG GNNNNNNNNC CGAA AAUUAAGG	7035
5105	AGGAACGUC GGCAGAGG	2887	CCUCUGCC CUGAUGAG GNNNNNNNNC CGAA ACGUUCCU	7036
5116	CAGAGGCUC CUGACGGG	2888	CCCGUCAG CUGAUGAG GNNNNNNNNC CGAA AGCCUCUG	7037
5135	CGAAGAAUU GUGAGAAC	2889	GUUCUCAC CUGAUGAG GNNNNNNNNC CGAA AUUCUUCG	7038
5156	CAGAAACUC AGGGUUUC	2890	GAAACCCU CUGAUGAG GNNNNNNNNC CGAA AGUUUCUG	7039
5162	CUCAGGGUU UCUGCUGG	2891	CCAGCAGA CUGAUGAG GNNNNNNNNC CGAA ACCCUGAG	7040
5163	UCAGGGUUU CUGCUGGG	2892	CCCAGCAG CUGAUGAG GNNNNNNNNC CGAA AACCCUGA	7041
5164	CAGGGUUUC UGCUGGGU	2893	ACCCAGCA CUGAUGAG GNNNNNNNNC CGAA AAACCCUG	7042
5203	UGGCAGGUC UGAGGGUU	2894	AACCCUCA CUGAUGAG GNNNNNNNNC CGAA ACCUGCCA	7043
5211	CUGAGGGUU CUCUGUCA	2895	UGACAGAG CUGAUGAG GNNNNNNNNC CGAA ACCCUCAG	7044
5212	UGAGGGUUC UCUGUCAA	2896	UUGACAGA CUGAUGAG GNNNNNNNNC CGAA AACCCUCA	7045
5214	AGGGUUCUC UGUCAAGU	2897	ACUUGACA CUGAUGAG GNNNNNNNNC CGAA AGAACCCU	7046
5218	UUCUCUGUC AAGUGGCG	2898	CGCCACUU CUGAUGAG GNNNNNNNNC CGAA ACAGAGAA	7047
5229	GUGGCGGUA AAGGCUCA	2899	UGAGCCUU CUGAUGAG GNNNNNNNNC CGAA ACCGCCAC	7048
5226	UAAAGGCUC AGGCUGGU	2900	ACCAGCCU CUGAUGAG GNNNNNNNNC CGAA AGCCUUUA	7049
5247	GCUGGUGUU CUUCCUCU	2901	AGAGGAAG CUGAUGAG GNNNNNNNNC CGAA ACACCAGC	7050
5248	CUGGUGUUC UUCCUCUA	2902	UAGAGGAA CUGAUGAG GNNNNNNNNC CGAA AACACCAG	7051
5250	GGUGUUCUU CCUCUAUC	2903	GAUAGAGG CUGAUGAG GNNNNNNNNC CGAA AGAACACC	7052
5251	GUGUUCUUC CUCUAUCU	2904	AGAUAGAG CUGAUGAG GNNNNNNNNC CGAA AAGAACAC	7053
5254	UUCUUCCUC UAUCUCCA	2905	UGGAGAUA CUGAUGAG GNNNNNNNNC CGAA AGGAAGAA	7054
5256	CUUCCUCUA UCUCCACU	2906	AGUGGAGA CUGAUGAG GNNNNNNNNC CGAA AGAGGAAG	7055
5258	UCCUCUAUC UCCACUCC	2907	GGAGUGGA CUGAUGAG GNNNNNNNNC CGAA AUAGAGGA	7056
5260	CUCUAUCUC CACUCCUG	2908	CAGGAGUG CUGAUGAG GNNNNNNNNC CGAA AGAUAGAG	7057
5265	UCUCCACUC CUGUCAGG	2909	CCUGACAG CUGAUGAG GNNNNNNNNC CGAA AGUGGAGA	7058
5270	ACUCCUGUC AGGCCCCC	2910	GGGGGCCU CUGAUGAG GNNNNNNNNC CGAA ACAGGAGU	7059
5283	CCCCAAGUC CUCAGUAU	2911	AUACUGAG CUGAUGAG GNNNNNNNNC CGAA ACUUGGGG	7060
5286	CAAGUCCUC AGUAUUUU	2912	AAAAUACU CUGAUGAG GNNNNNNNNC CGAA AGGACUUG	7061
5290	UCCUCAGUA UUUUAGCU	2913	AGCUAAAA CUGAUGAG GNNNNNNNNC CGAA ACUGAGGA	7062
5292	CUCAGUAUU UUAGCUUU	2914	AAAGCUAA CUGAUGAG GNNNNNNNNC CGAA AUACUGAG	7063
5293	UCAGUAUUU UAGCUUUG	2915	CAAAGCUA CUGAUGAG GNNNNNNNNC CGAA AAUACUGA	7064
5294	CAGUAUUUU AGCUUUGU	2916	ACAAAGCU CUGAUGAG GNNNNNNNNC CGAA AAAUACUG	7065
5295	AGUAUUUUA GCUUUGUG	2917	CACAAAGC CUGAUGAG GNNNNNNNNC CGAA AAAAUACU	7066
5299	UUUUAGCUU UGUGGCUU	2918	AAGCCACA CUGAUGAG GNNNNNNNNC CGAA AGCUAAAA	7067
5300	UUUAGCUUU GUGGCUUC	2919	GAAGCCAC CUGAUGAG GNNNNNNNNC CGAA AAGCUAAA	7068
5307	UUGUGGCUU CCUGAUGG	2920	CCAUCAGG CUGAUGAG GNNNNNNNNC CGAA AGCCACAA	7069
5308	UGUGGCUUC CUGAUGGC	2921	GCCAUCAG CUGAUGAG GNNNNNNNNC CGAA AAGCCACA	7070
5325	AGAAAAAUC UUAAUUGG	2922	CCAAUUAA CUGAUGAG GNNNNNNNNC CGAA AUUUUUCU	7071
5327	AAAAAUCUU AAUUGGUU	2923	AACCAAUU CUGAUGAG GNNNNNNNNC CGAA AGAUUUUU	7072
5328	AAAAUCUUA AUUGGUUG	2924	CAACCAAU CUGAUGAG GNNNNNNNNC CGAA AAGAUUUU	7073
5331	AUCUUAAUU GGUUGGUU	2925	AACCAACC CUGAUGAG GNNNNNNNNC CGAA AUUAAGAU	7074
5335	UAAUUGGUU GGUUUGCU	2926	AGCAAACC CUGAUGAG GNNNNNNNNC CGAA ACCAAUUA	7075
5339	UGGUUGGUU UGCUCUCC	2927	GGAGAGCA CUGAUGAG GNNNNNNNNC CGAA ACCAACCA	7076
5340	GGUUGGUUU GCUCUCCA	2928	UGGAGAGC CUGAUGAG GNNNNNNNNC CGAA AACCAACC	7077
5344	GGUUUGCUC UCCAGAUA	2929	UAUCUGGA CUGAUGAG GNNNNNNNNC CGAA AGCAAACC	7078
5346	UUUGCUCUC CAGAUAAU	2930	AUUAUCUG CUGAUGAG GNNNNNNNNC CGAA AGAGCAAA	7079
5352	CUCCAGAUA AUCACUAG	2931	CUAGUGAU CUGAUGAG GNNNNNNNNC CGAA AUCUGGAG	7080
5355	CAGAUAAUC ACUAGCCA	2932	UGGCUAGU CUGAUGAG GNNNNNNNNC CGAA AUUAUCUG	7081
5359	UAAUCACUA GCCAGAUU	2933	AAUCUGGC CUGAUGAG GNNNNNNNNC CGAA AGUGAUUA	7082
5367	AGCCAGAUU UCGAAAUU	2934	AAUUUCGA CUGAUGAG GNNNNNNNNC CGAA AUCUGGCU	7083
5368	GCCAGAUUU CGAAAUUA	2935	UAAUUUCG CUGAUGAG GNNNNNNNNC CGAA AAUCUGGC	7084
5369	CCAGAUUUC GAAAUUAC	2936	GUAAUUUC CUGAUGAG GNNNNNNNNC CGAA AAAUCUGG	7085
5375	UUCGAAAUU ACUUUUUA	2937	UAAAAAGU CUGAUGAG GNNNNNNNNC CGAA AUUUCGAA	7086
5376	UCGAAAUUA CUUUUUAG	2938	CUAAAAAG CUGAUGAG GNNNNNNNNC CGAA AAUUUCGA	7087
5379	AAAUUACUU UUUAGCCG	2939	CGGCUAAA CUGAUGAG GNNNNNNNNC CGAA AGUAAUUU	7088
5380	AAUUACUUU UUAGCCGA	2940	UCGGCUAA CUGAUGAG GNNNNNNNNC CGAA AAGUAAUU	7089
5381	AUUACUUUU UAGCCGAG	2941	CUCGGCUA CUGAUGAG GNNNNNNNNC CGAA AAAGUAAU	7090
5382	UUACUUUUU AGCCGAGG	2942	CCUCGGCU CUGAUGAG GNNNNNNNNC CGAA AAAAGUAA	7091
5383	UACUUUUUA GCCGAGGU	2943	ACCUCGGC CUGAUGAG GNNNNNNNNC CGAA AAAAAGUA	7092
5392	GCCGAGGUU AUGAUAAC	2944	GUUAUCAU CUGAUGAG GNNNNNNNNC CGAA ACCUCGGC	7093
5393	CCGAGGUUA UGAUAACA	2945	UGUUAUCA CUGAUGAG GNNNNNNNNC CGAA AACCUCGG	7094
5398	GUUAUGAUA ACAUCUAC	2946	GUAGAUGU CUGAUGAG GNNNNNNNNC CGAA AUCAUAAC	7095
5403	GAUAACAUC UACUGUAU	2947	AUACAGUA CUGAUGAG GNNNNNNNNC CGAA AUGUUAUC	7096
5405	UAACAUCUA CUGUAUCC	2948	GGAUACAG CUGAUGAG GNNNNNNNNC CGAA AGAUGUUA	7097
5410	UCUACUGUA UCCUUUAG	2949	CUAAAGGA CUGAUGAG GNNNNNNNNC CGAA ACAGUAGA	7098
5412	UACUGUAUC CUUUAGAA	2950	UUCUAAAG CUGAUGAG GNNNNNNNNC CGAA AUACAGUA	7099
5415	UGUAUCCUU UAGAAUUU	2951	AAAUUCUA CUGAUGAG GNNNNNNNNC CGAA AGGAUACA	7100
5416	GUAUCCUUU AGAAUUUU	2952	AAAAUUCU CUGAUGAG GNNNNNNNNC CGAA AAGGAUAC	7101
5417	UAUCCUUUA GAAUUUUA	2953	UAAAAUUC CUGAUGAG GNNNNNNNNC CGAA AAAGGAUA	7102
5422	UUUAGAAUU UUAACCUA	2954	UAGGUUAA CUGAUGAG GNNNNNNNNC CGAA AUUCUAAA	7103
5423	UUAGAAUUU UAACCUAU	2955	AUAGGUUA CUGAUGAG GNNNNNNNNC CGAA AAUUCUAA	7104
5424	UAGAAUUUU AACCUAUA	2956	UAUAGGUU CUGAUGAG GNNNNNNNNC CGAA AAAUUCUA	7105
5425	AGAAUUUUA ACCUAUAA	2957	UUAUAGGU CUGAUGAGGcsCCGUUAGGCCGAA AAAAUUCU	7106
5430	UUUAACCUA UAAAACUA	2958	UAGUUUUA CUGAUGAG GNNNNNNNNC CGAA AGGUUAAA	7107
5432	UAACCUAUA AAACUAUG	2959	CAUAGUUU CUGAUGAG GNNNNNNNNC CGAA AUAGGUUA	7108
5438	AUAAAACUA UGUCUACU	2960	AGUAGACA CUGAUGAG GNNNNNNNNC CGAA AGUUUUAU	7109
5442	AACUAUGUC UACUGGUU	2961	AACCAGUA CUGAUGAG GNNNNNNNNC CGAA ACAUAGUU	7110
5444	CUAUGUCUA CUGGUUUC	2962	GAAACCAG CUGAUGAG GNNNNNNNNC CGAA AGACAUAG	7111
5450	CUACUGGUU UCUGCCUG	2963	CAGGCAGA CUGAUGAG GNNNNNNNNC CGAA ACCAGUAG	7112
5451	UACUGGUUU CUGCCUGU	2964	ACAGGCAG CUGAUGAG GNNNNNNNNC CGAA AACCAGUA	7113
5452	ACUGGUUUC UGCCUGUG	2965	CACAGGCA CUGAUGAG GNNNNNNNNC CGAA AAACCAGU	7114
Where “X” represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be ≧ 2 base-pairs.
Underlined region can be any X sequence or linker, as described herein.

TABLE VII
Mouse flt-1 VEGF Receptor-Hairpin Ribozyme and Substrate Sequence 5
		Seq ID		Seq ID
Pos	Substrate	No	HP Ribozyme	No
74	GGGCCCA GAC UGUGUCCC	2966	GGGACACA AGAA GGGCCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7115
88	UCCCGCA GCC GGGAUAAC	2967	GUUAUCCC AGAA GCGGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7116
105	CCUGGCU GAC CCGAUUCC	2968	GGAAUCGG AGAA GCCAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7117
110	CUGACCC GAU UCCGCGGA	2969	UCCGCGGA AGAA GGUCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7118
125	GGACACC GCU GACAGCCG	2970	CGGCUGUC AGAA GUGUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7119
132	GCUGACA GCC GCGGCUGG	2971	CCAGCCGC AGAA GUCAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7120
138	AGCCGCG GCU GGAGCCAG	2972	CUGGCUCC AGAA GCGGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7121
175	CUCCCCG GUC UUGCGCUG	2973	CAGCGCAA AGAA GGGGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7122
199	CCAUACC GCC UCUGUGAC	2974	GUCACAGA AGAA GUAUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7123
309	GCUAGCU GUC GCUCUGUG	2975	CACAGAGC AGAA GCUAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7124
342	CCGAGCC GCC UCUGUGGG	2976	CCCACAGA AGAA GCUCGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7125
434	CCCUUCA GAU UACUUGCA	2977	UGCAAGUA AGAA GAAGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7126
630	CUCCACU GUU UAUGUCUA	2978	UAGACAUA AGAA GUGGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7127
655	GAUUACA GAU CACCAUUC	2979	GAAUGGUG AGAA GUAAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7128
739	AUCCCCU GCC GAGGGUCG	2980	CGACCCUC AGAA GGGGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7129
807	UGUUCCG GAU GGAAACAG	2981	CUGUUUCC AGAA GGAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7130
920	CCUAUCA GUC UAUCAUGU	2982	ACAUGAUA AGAA GAUAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7131
1002	GCUAUCU GCC GGAGAAAA	2983	UUUUCUCC AGAA GAUAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7132
1229	GUGGACG GAU GAUCAAGA	2984	UCUUGAUC AGAA GUCCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7133
1365	UUACCCA GCU CCUGAUAU	2985	AUAUCAGG AGAA GGGUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7134
1556	CACCCCA GAU CGGUGAGA	2986	UCUCACCG AGAA GGGGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7135
1629	AUGCACA GUC UACGCCAA	2987	UUGGCGUA AGAA GUGCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7136
1687	GAAGCCU GCU CCUACAGA	2988	UCUGUAGG AGAA GGCUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7137
1696	UCCUACA GAC CCGGCCAA	2989	UUGGCCGG AGAA GUAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7138
1796	AUGCCCU GAU UGAAGGAA	2990	UUCCUUCA AGAA GGGCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7139
1950	GCAACCU GCU GCCCAGCC	2991	GGCUGGGC AGAA GGUUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7140
1953	ACCUGCU GCC CAGCCAAC	2992	GUUGGCUG AGAA GCAGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7141
1985	UGUCCCU GUU GUGCACUG	2993	CAGUGCAC AGAA GGGACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7142
2055	AACAUCG GUC CACAUGGG	2994	CCCAUGUG AGAA GAUGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7143
2082	CACACCA GUU UGCAAGAA	2995	UUCUUGCA AGAA GGUGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6343
2208	UUGCUCU GCU CAAGAUAA	2996	UUAUCUUG AGAA GAGCAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7144
2252	UCAAACA GCU CAUCAUCC	2997	GGAUGAUG AGAA GUUUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7145
2444	GGAACCU GAC UAUCCGCA	2998	UGCGGAUA AGAA GGUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7146
2639	UCCUACG GAC CGUUAAGC	2999	GCUUAACG AGAA GUAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7147
2703	GGAUCCA GAU GAAUUGCC	3000	GGCAAUUC AGAA GGAUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7148
2777	GGGACCG GCU GAAACUAG	3001	CUAGUUUC AGAA GGUCCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7149
2832	UGAGGCA GAC GCUUUUGG	3002	CCAAAAGC AGAA GCCUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7150
3199	UCUGCCA GCU CAGGCUUU	3003	AAAGCCUG AGAA GGCAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7151
3278	ACUUCCU GAC CUUGGAGC	2199	GCUCCAAG AGAA GGAAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6355
3304	UGUUACA GCU UCCAAGUG	2200	CACUUGGA AGAA GUAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6356
3421	GACUUCG GCU UGGCCCGG	3004	CCGGGCCA AGAA GAAGUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7152
3450	AGACCCG GAU UAUGUCAG	3005	CUGACAUA AGAA GGGUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7153
3475	GAUGCCC GAC UCCCUUUG	3006	CAAAGGGA AGAA GGCAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7154
3663	GGCUCCU GAC UACACUAC	3007	GUAGUGUA AGAA GGAGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7155
3689	UGUACCA GAC CAUGCUGG	2203	CCAGCAUG AGAA GGUACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6359
3703	CUGGACU GCU GGCAUGAG	3008	CUCAUGCC AGAA GUCCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7156
3860	UCUCCCU GCC UACCUCAC	3009	GUGAGGUA AGAA GGGAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7157
3873	CUCACCU GUU UCCUGUAU	2206	AUACAGGA AGAA GGUGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6362
4038	GAUCCCA GAU GACAGCCA	3010	UGGCUGUC AGAA GGGAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7158
4181	CCAACCA GAC CAGUGGCU	3011	AGCCACUG AGAA GGUUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7159
4196	GCUACCA GUC UGGGUAUC	3012	GAUACCCA AGAA GGUAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7160
4212	UCACUCA GAU GACACAGA	3013	UCUGUGUC AGAA GAGUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	6367
4278	UGCUGCA GUU CACGCUGA	3014	UCAGCGUG AGAA GCAGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7161
4287	UCACGCU GAC UCAGGGAC	3015	GUCCCUGA AGAA GCGUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUddUA	7162
4307	CACUGCA GCU CACCUCCU	3016	AGGAGGUG AGAA GCAGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7163
4318	ACCUCCU GUU UAAAUGGA	3017	UCCAUUUA AGAA GGAGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7164
4338	UGGUCCU GUC CCGGCUCC	3018	GGAGCCGG AGAA GGACCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7165
4344	UGUCCCG GCU CCGCCCCC	3019	GGGGGCGG AGAA GGGACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7166
4349	CGGCUCC GCC CCCAACUC	3020	GAGUUGGG AGAA GAGCCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7167
4383	AGGUGCU GCU UAGAUUUU	3021	AAAAUCUA AGAA GCACCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7168
4462	GACCUCA GAC UGCAAGGA	3022	UCCUUGCA AGAA GAGGUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7169
4574	GUGCCCU GCU GUGGUCUC	3023	GAGACCAC AGAA GGGCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7170
4626	GGACUCU GUC CUCCAAGA	3024	UCUUGGAG AGAA GAGUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7171
4723	CGAGUCU GUC UACCUUGG	3025	CCAAGGUA AGAA GACUCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7172
4823	GAGAGCG GUU GGAGCCUG	3026	CAGGCUCC AGAA GCUCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7173
4836	GCCUGCA GAU GCAUUGUG	3027	CACAAUGC AGAA GCAGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7174
4896	AAAGGCG GCC GGCAGGGU	3028	ACCCUGCC AGAA GCCUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7175
4938	CUUCACA GUC GGGUUACA	3029	UGUAACCC AGAA GUGAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7176
4996	CCUUCCG GAC UCUUACGU	3030	ACGUAAGA AGAA GGAAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7177
5042	UGAUGCA GCU UGCUCCUU	3031	AAGGAGCA AGAA GCAUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7178
5118	GGCUCCU GAC GGGGCCGA	3032	UCGGCCCC AGAA GGAGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7179
5165	GGUUUCU GCU GGGUGGAG	3033	CUCCACCC AGAA GAAACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7180
5310	GCUUCCU GAU GGCAGAAA	3034	UUUCUGCC AGAA GGAAGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7181
5363	CUAGCCA GAU UUCGAAAU	3035	AUUUCGAA AGAA GGCUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7182
5453	GGUUUCU GCC UGUGUGCU	3036	AGCACACA AGAA GAAACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	7183

TABLE VIII
Mouse flt -1 VEGF Receptor-Hammerhead Ribozyme and Substrate Sequence
		Seq		Seq
		ID		ID
Pos	Substrate	No	HH Ribozyme Sequence	No
17	GGCCGCGUC UUGCUCAC	3037	GUGAGCAA CUGAUGAG GNNNNNNNNC CGAA ACGCGGCC	7184
19	CCGCGUCUU GCUCACCA	3038	UGGUGAGC CUGAUGAG GNNNNNNNNC CGAA AGACGCGG	7185
23	GUCUUGCUC ACCAUGGU	3039	ACCAUGGU CUGAUGAG GNNNNNNNNC CGAA AGCAAGAC	7186
32	ACCAUGGUC AGCUGCUG	3040	CAGCAGCU CUGAUGAG GNNNNNNNNC CGAA ACCAUGGU	7187
53	ACCGCGGUC UUGCCUUA	3041	UAAGGCAA CUGAUGAG GNNNNNNNNC CGAA ACCGCGGU	7188
55	CGCGGUCUU GCCUUACG	3042	CGUAAGGC CUGAUGAG GNNNNNNNNC CGAA AGACCGCG	7189
60	UCUUGCCUU ACGCGCUG	3043	CAGCGCGU CUGAUGAG GNNNNNNNNC CGAA AGGCAAGA	7190
61	CUUGCCUUA CGCGCUGC	3044	GCAGCGCG CUGAUGAG GNNNNNNNNC CGAA AAGGCAAG	7191
71	GCGCUGCUC GGGUGUCU	3045	AGACACCC CUGAUGAG GNNNNNNNNC CGAA AGCAGCGC	7192
78	UCGGGUGUC UGCUUCUC	3046	GAGAAGCA CUGAUGAG GNNNNNNNNC CGAA ACACCCGA	7193
83	UGUCUGCUU CUCACAGG	25	ACUGUGAG CUGAUGAG GNNNNNNNNC CGAA AGCAGACA	4181
84	GUCUGCUUC UCACAGGA	26	UCCUGUGA CUGAUGAG GNNNNNNNNC CGAA AAGCAGAC	4182
86	CUGCUUCUC ACAGGAUA	3047	UAUCCUGU CUGAUGAG GNNNNNNNNC CGAA AGAAGCAG	7194
94	CACAGGAUA UGGCUCAG	3048	CUGAGCCA CUGAUGAG GNNNNNNNNC CGAA AUCCUGUG	7195
100	AUAUGGCUC AGGGUCGA	3049	UCGACCCU CUGAUGAG GNNNNNNNNC CGAA AGCCAUAU	7196
106	CUCAGGGUC GAAGUUAA	3050	UUAACUUC CUGAUGAG GNNNNNNNNC CGAA ACCCUGAG	7197
112	GUCGAAGUU AAAAGUGC	3051	GCAGUUUU CUGAUGAG GNNNNNNNNC CGAA ACUUCGAC	7198
113	UCGAAGUUA AAAGUGCC	3052	GGCACUUU CUGAUGAG GNNNNNNNNC CGAA AACUUCGA	7199
132	AACUGAGUU AUAAAGGC	37	GCCUUUUA CUGAUGAG GNNNNNNNNC CGAA ACUCAGUU	4193
133	ACUGAGUUU AAAAGGCA	38	UGCCUUUU CUGAUGAG GNNNNNNNNC CGAA AACUCAGU	4194
134	CUGAGUUUC AAAGGCAC	39	GUGCCUUU CUGAUGAG GNNNNNNNNC CGAA AAACUCAG	4195
152	CAGCAUGUC AUGCAAGC	3053	GCUUGCAU CUGAUGAG GNNNNNNNNC CGAA ACAUGCUG	7200
171	GCCAGACUC UCUUUCUC	3054	GAGAAAGA CUGAUGAG GNNNNNNNNC CGAA AGUCUGGC	7201
173	CAGACUCUC UUUCUCAA	3055	UUGAGAAA CUGAUGAG GNNNNNNNNC CGAA AGAGUCUG	7202
175	GACUCUCUU UCUCAAGU	3056	ACUUGAGA CUGAUGAG GNNNNNNNNC CGAA AGAGAGUC	7203
176	ACUCUCUUU CUCAAGUG	3057	CACUUGAG CUGAUGAG GNNNNNNNNC CGAA AAGAGAGU	7204
177	CUCUCUUUC UCAAGUGC	3058	GCACUUGA CUGAUGAG GNNNNNNNNC CGAA AAAGAGAG	7205
179	CUCUUUCUC AAGUGCAG	3059	CUGCACUU CUGAUGAG GNNNNNNNNC CGAA AGAAAGAG	7206
205	AGCCCACUC AUGGUCUC	3060	GAGACCAU CUGAUGAG GNNNNNNNNC CGAA AGUGGGCU	7207
211	CUCAUGGUC UCUGCCCA	3061	UGGGCAGA CUGAUGAG GNNNNNNNNC CGAA ACCAUGAG	7208
213	CAUGGUCUC UGCCCACG	3062	CGUGGGCA CUGAUGAG GNNNNNNNNC CGAA AGACCAUG	7209
254	CUGAGCAUC ACUCCCCC	3063	GGGGGAGU CUGAUGAG GNNNNNNNNC CGAA AUGCUCAG	7210
258	GCAUCACUC CCCCAUCG	3064	CGAUGGGG CUGAUGAG GNNNNNNNNC CGAA AGUGAUGC	7211
265	UCCCCCAUC GGCCUGUG	3065	CACAGGCC CUGAUGAG GNNNNNNNNC CGAA AUGGGGGA	7212
282	GGAGGGAUA ACAGGCAA	3066	UUGCCUGU CUGAUGAG GNNNNNNNNC CGAA AUCCCUCC	7213
292	CAGGCAAUU CUGCAGCA	3067	UGCUGCAG CUGAUGAG GNNNNNNNNC CGAA AUUGCCUG	7214
293	AGGCAAUUC UGCAGCAC	3068	GUGCUGCA CUGAUGAG GNNNNNNNNC CGAA AAGGUCCU	7215
304	CAGCACCUU GACCUUGG	3069	CCAAGGUC CUGAUGAG GNNNNNNNNC CGAA AGGUGCUG	7216
310	CUUGACCUU GGACACGG	3070	GGCUCUGG CUGAUGAG GNNNNNNNNC CGAA AGGUCAAG	7217
341	ACGGGCCUC UACACCUG	3071	CAGGUGUA CUGAUGAG GNNNNNNNNC CGAA AGGCCCGU	7218
343	GGGCCUCUA CACCUGUA	3072	UACAGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGGCCC	7219
351	ACACCUGUA GAUACCUC	3073	GAGGUAUC CUGAUGAG GNNNNNNNNC CGAA ACAGGUGU	7220
355	CUGUAGAUA CCUCCCUA	3074	UAGGGAGG CUGAUGAG GNNNNNNNNC CGAA AUCUACAG	7221
359	AGAUACCUC CCUACAUC	3075	GAUGUAGG CUGAUGAG GNNNNNNNNC CGAA AGGUAUCU	7222
363	ACCUCCCUA CAUCUACU	3076	AGUAGAUG CUGAUGAG GNNNNNNNNC CGAA AGGGAGGU	7223
367	CCCUACAUC UACUUCGA	3077	UCGAAGUA CUGAUGAG GNNNNNNNNC CGAA AUGUAGGG	7224
369	CUACAUCUA CUUCGAAG	3078	CUUCGAAG CUGAUGAG GNNNNNNNNC CGAA AGAUGUAG	7225
372	CAUCUACUU CGAAGAAA	3079	UUUCUUCG CUGAUGAG GNNNNNNNNC CGAA AGUAGAUG	7226
373	AUCUACUUC GAAGAAAA	3080	UUUUCUUC CUGAUGAG GNNNNNNNNC CGAA AAGUAGAU	7227
394	AGCGGAAUC UUCAAUCU	3081	AGAUUGAA CUGAUGAG GNNNNNNNNC CGAA AUUCCGCU	7228
396	CGGAAUCUU CAAUCUAC	3082	GUAGAUUG CUGAUGAG GNNNNNNNNC CGAA AGAUUCCG	7229
397	GGAAUCUUC AAUCUACA	3083	UGUAGAUU CUGAUGAG GNNNNNNNNC CGAA AAGAUUCC	7230
401	UCUUCAAUC UACAUAUU	3084	AAUAUGUA CUGAUGAG GNNNNNNNNC CGAA AUUGAAGA	7231
403	UUCAAUCUA CAUAUUUG	3085	CAAAUAUG CUGAUGAG GNNNNNNNNC CGAA AGAUUGAA	7232
407	AUCUACAUA UUUGUUAG	3086	CUAACAAA CUGAUGAG GNNNNNNNNC CGAA AUGUAGAU	7233
409	CUACAUAUU UGUUAGUG	3087	CACUAACA CUGAUGAG GNNNNNNNNC CGAA AUAUGUAG	7234
410	UACAUAUUU GUUAGUGA	3088	UCACUAAC CUGAUGAG GNNNNNNNNC CGAA AAUAUGUA	7235
413	AUAUUUGUU AGUGAUGC	3089	GCAUCACU CUGAUGAG GNNNNNNNNC CGAA ACAAAUAU	7236
414	UAUUUGUUA GUGAUGCA	3090	UGCAUCAC CUGAUGAG GNNNNNNNNC CGAA AACAAAUA	7237
429	CAGGGAGUC CUUUCAUA	3091	UAUGCCCG CUGAUGAG GNNNNNNNNC CGAA ACUCCCUG	7238
432	GGAGUCCUU UCAUAGAG	3092	CUCUAUGA CUGAUGAG GNNNNNNNNC CGAA AGGACUCC	7239
433	GAGUCCUUU CAUAGAGA	3093	UCUCUAUG CUGAUGAG GNNNNNNNNC CGAA AACCACUC	7240
434	AGUCCUUUC AUAGAGAU	3094	AUCUCUAU CUGAUGAG GNNNNNNNNC CGAA AAAGGACU	7241
437	CCUUUCAUA GAGAUGCA	3095	UGCAUCUC CUGAUGAG GNNNNNNNNC CGAA AUGAAAGG	7242
455	ACUGACAUA CCCAAACU	3096	AGUUUGGG CUGAUGAG GNNNNNNNNC CGAA AUGUCAGU	7243
464	CCCAAACUU GUGCACAU	3097	AUGUGCAC CUGAUGAG GNNNNNNNNC CGAA AGUUUGGG	7244
491	AGACAGCUC AUCAUCCC	3098	GGGAUGAU CUGAUGAG GNNNNNNNNC CGAA AGCUGUCU	7245
494	CAGCUCAUC AUCCCCUG	3099	CAGGGGAU CUGAUGAG GNNNNNNNNC CGAA AUGAGCUG	7246
497	CUCAUCAUC CCCUGCCG	3100	CGGCAGGG CUGAUGAG GNNNNNNNNC CGAA AUGAUGAG	7247
514	GGUGACGUC ACCCAACG	3101	CGUUGGGU CUGAUGAG GNNNNNNNNC CGAA ACGUCACC	7248
524	CCCAACGUC ACAGUCAC	3102	GUGACUGU CUGAUGAG GNNNNNNNNC CGAA ACGUUGGG	7249
530	GUCACAGUC ACCCUAAA	3103	UUUAGGGU CUGAUGAG GNNNNNNNNC CGAA ACUGUGAC	7250
536	GUCACCCUA AAAAAGUU	3104	AACUUUUU CUGAUGAG GNNNNNNNNC CGAA AGGGUGAC	7251
544	AAAAAAGUU UCCAUUUG	3105	CAAAUGGA CUGAUGAG GNNNNNNNNC CGAA ACUUUUUU	7252
545	AAAAAGUUU CCAUUUGA	3106	UCAAAUGG CUGAUGAG GNNNNNNNNC CGAA AACUUUUU	7253
546	AAAAGUUUC CAUUUGAU	3107	AUCAAAUG CUGAUGAG GNNNNNNNNC CGAA AAACUUUU	7254
550	GUUUCCAUU UGAUACUC	3108	GAGUAUCA CUGAUGAG GNNNNNNNNC CGAA AUGGAAAC	7255
551	UUUCCAUUU GAUACUCU	3109	AGAGUAUC CUGAUGAG GNNNNNNNNC CGAA AAUCCAAA	7256
555	CAUUUGAUA CUCUUACC	3110	GGUAAGAG CUGAUGAG GNNNNNNNNC CGAA AUCAAAUG	7257
558	UUGAUACUC UUACCCCU	3111	AGGGGUAA CUGAUGAG GNNNNNNNNC CGAA AGUAUCAA	7258
560	GAUACUCUU ACCCCUGA	3112	UCAGGGGU CUGAUGAG GNNNNNNNNC CGAA AGAGUAUC	7259
561	AUACUCUUA CCCCUGAU	3113	AUCAGGGG CUGAUGAG GNNNNNNNNC CGAA AAGAGUAU	7260
581	CAAAGAAUA ACAUGGGA	3114	UCCCAUGU CUGAUGAG GNNNNNNNNC CGAA AUUCUUUG	7261
594	GGGACAGUA GGAGAGGC	3115	GCCUCUCC CUGAUGAG GNNNNNNNNC CGAA ACUGUCCC	7262
604	GAGAGGCUU UAUAAUAG	3116	CUAUUAUA CUGAUGAG GNNNNNNNNC CGAA AGCCUCUC	7263
605	AGAGGCUUU AUAAUAGC	3117	GCUAUUAU CUGAUGAG GNNNNNNNNC CGAA AAGCCUCU	7264
606	GAGGCUUUA UAAUAGCA	3118	UGCUAUUA CUGAUGAG GNNNNNNNNC CGAA AAAGCCUC	7265
608	GGCUUUAUA AUAGCAAA	3119	UUUGCUAU CUGAUGAG GNNNNNNNNC CGAA AUAAAGCC	7266
611	UUUAUAAUA GCAAAUGC	3120	GCAUUUGC CUGAUGAG GNNNNNNNNC CGAA AUUAUAAA	7267
625	UGCAACGUA CAAAGAGA	3121	UCUCUUUG CUGAUGAG GNNNNNNNNC CGAA ACGUUGCA	7268
635	AAAGAGAUA GGACUGCU	3122	AGCAGUCC CUGAUGAG GNNNNNNNNC CGAA AUCUCUUU	7269
662	GCCACCGUC AACGGGCA	3123	UGCCCGUU CUGAUGAG GNNNNNNNNC CGAA ACGGUGGC	7270
676	GCACCUGUA CCAGACAA	3124	UUGUCUGG CUGAUGAG GNNNNNNNNC CGAA ACAGGUGC	7271
688	GACAAACUA UCUGACCC	3125	GGGUCAGA CUGAUGAG GNNNNNNNNC CGAA AGUUUGUC	7272
690	CAAACUAUC UGACCCAU	3126	AUGGGUCA CUGAUGAG GNNNNNNNNC CGAA AUAGUUUG	7273
699	UGACCCAUC GGCAGACC	3127	GGUCUGCC CUGAUGAG GNNNNNNNNC CGAA AUGGGUCA	7274
711	AGACCAAUA CAAUCCUA	3128	UAGGAUUG CUGAUGAG GNNNNNNNNC CGAA AUUGGUCU	7275
716	AAUACAAUC CUAGAUGU	3129	ACAUCUAG CUGAUGAG GNNNNNNNNC CGAA AUUGUAUU	7276
719	ACAAUCCUA GAUGUCCA	3130	UGGACAUC CUGAUGAG GNNNNNNNNC CGAA AGGAUUGU	7277
725	CUAGAUGUC CAAAUACG	3131	CGUAUUUG CUGAUGAG GNNNNNNNNC CGAA ACAUCUAG	7278
731	GUCCAAAUA CGCCCGCC	3132	GGCGGGCG CUGAUGAG GNNNNNNNNC CGAA AUUUGGAC	7279
758	AGACUGCUC CACGGGCA	3133	UGCCCGUG CUGAUGAG GNNNNNNNNC CGAA AGCAGUCU	7280
771	GGCAGACUC UUGUCCUC	3134	GAGGACAA CUGAUGAG GNNNNNNNNC CGAA AGUCUGCC	7281
773	CAGACUCUU GUCCUCAA	3135	UUCAGGAC CUGAUGAG GNNNNNNNNC CGAA AGAGUCUG	7282
776	ACUCUUGUC CUCAACUG	3136	CAGUUGAG CUGAUGAG GNNNNNNNNC CGAA ACAAGAGU	7283
779	CUUGUCCUC AACUGCAC	3137	GUGCAGUU CUGAUGAG GNNNNNNNNC CGAA AGGACAAG	7284
803	ACGGAGCUC AAUACGAG	3138	CUCGUAUU CUGAUGAG GNNNNNNNNC CGAA AGCUCCGU	7285
807	AGCUCAAUA CGAGGGUG	3139	CACCCUCG CUGAUGAG GNNNNNNNNC CGAA AUUGAGCU	7286
831	GCUGGAAUU ACCCUGGU	3140	ACCAGGGU CUGAUGAG GNNNNNNNNC CGAA AUUCCAGC	7287
832	CUGGAAUUA CCCUGGUA	3141	UACCAGGG CUGAUGAG GNNNNNNNNC CGAA AAUUCCAG	7288
840	ACCCUGGUA AAGCAACU	3142	AGUUGCUU CUGAUGAG GNNNNNNNNC CGAA ACCAGGGU	7289
849	AAGCAACUA AGAGAGCA	3143	UGCUCUCU CUGAUGAG GNNNNNNNNC CGAA AGUUGCUU	7290
859	GAGAGCAUC UAUAAGGC	3144	GCCUUAUA CUGAUGAG GNNNNNNNNC CGAA AUGCUCUC	7291
861	GAGCAUCUA UAAGGCAG	3145	CUGCCUUA CUGAUGAG GNNNNNNNNC CGAA AGAUGCUC	7292
863	GCAUCUAUA AGGCAGCG	3146	CGCUGCCU CUGAUGAG GNNNNNNNNC CGAA AUAGAUGC	7293
875	CAGCGGAUU GACCGGAG	3147	CUCCGGUC CUGAUGAG GNNNNNNNNC CGAA AUCCGCUG	7294
888	GGAGCCAUU CCCACAAC	3148	GUUGUGGG CUGAUGAG GNNNNNNNNC CGAA AUGGCUCC	7295
889	GAGCCAUUC CCACAACA	3149	UGUUGUGG CUGAUGAG GNNNNNNNNC CGAA AAUGGCUC	7296
904	CAAUGUGUU CCACAGUG	3150	CACUGUGG CUGAUGAG GNNNNNNNNC CGAA ACACAUUG	7297
905	AAUGUGUUC CACAGUGU	3151	ACACUGUG CUGAUGAG GNNNNNNNNC CGAA AACACAUU	7298
914	CACAGUGUU CUUAAGAU	3152	AUCUUAAG CUGAUGAG GNNNNNNNNC CGAA ACACUGUG	7299
915	ACAGUGUUC UUAAGAUC	3153	GAUCUUAA CUGAUGAG GNNNNNNNNC CGAA AACACUGU	7300
917	AGUGUUCUU AAGAUCAA	3154	UUGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGAACACU	7301
918	GUGUUCUUA AGAUCAAC	3155	GUUGAUCU CUGAUGAG GNNNNNNNNC CGAA AAGAACAC	7302
923	CUUAAGAUC AACAAUGU	3156	ACAUUGUU CUGAUGAG GNNNNNNNNC CGAA AUCUUAAG	7303
953	AAGGGGCUC UACACCUG	3157	CAGGUGUA CUGAUGAG GNNNNNNNNC CGAA AGCCCCUU	7304
955	GGGGCUCUA CACCUGUC	3158	GACAGGUG CUGAUGAG GNNNNNNNNC CGAA AGAGCCCC	7305
963	ACACCUGUC GCGUGAAG	3159	CUUCACGC CUGAUGAG GNNNNNNNNC CGAA ACAGGUGU	7306
979	GAGUGGGUC CUCGUUCC	3160	GGAACGAG CUGAUGAG GNNNNNNNNC CGAA ACCCACUC	7307
982	UGGGUCCUC GUUCCAGU	3161	ACUGGAAC CUGAUGAG GNNNNNNNNC CGAA AGGACCCA	7308
985	GUCCUCGUU CCAGUCUU	3162	AAGACUGG CUGAUGAG GNNNNNNNNC CGAA ACGAGGAC	7309
986	UCCUCGUUC CAGUCUUU	3163	AAAGACUG CUGAUGAG GNNNNNNNNC CGAA AACGAGGA	7310
991	GUUCCAGUC UUUCAACA	3164	UGUUGAAA CUGAUGAG GNNNNNNNNC CGAA ACUGGAAC	7311
993	UCCAGUCUU UCAACACC	3165	GGUGUUGA CUGAUGAG GNNNNNNNNC CGAA AGACUGGA	7312
994	CCUGUCUUU CAACACCU	3166	AGGUGUUG CUGAUGAG GNNNNNNNNC CGAA AAGACUGG	7313
995	CAGUCUUUC AACACCUC	3167	GAGGUGUU CUGAUGAG GNNNNNNNNC CGAA AAAGACUG	7314
1003	CAACACCUC CGUGCAUG	3168	CAUGCACG CUGAUGAG GNNNNNNNNC CGAA AGGUGUUG	7315
1015	GCAUGUGUA UCAAAAAG	3169	CUUUUUCA CUGAUGAG GNNNNNNNNC CGAA ACACAUGC	7316
1027	AAAAGGAUU CAUCAGUG	3170	CACUGAUG CUGAUGAG GNNNNNNNNC CGAA AUCCUUUU	7317
1028	AAAGGAUUC AUCAGUGU	3171	ACACUGAU CUGAUGAG GNNNNNNNNC CGAA AAUCCUUU	7318
1031	GGAUUCAUC AGUGUGAA	3172	UUCACACU CUGAUGAG GNNNNNNNNC CGAA AUGAAUCC	7319
1044	UGAAACAUC GGAAGCAG	3173	CUGCUUCC CUGAUGAG GNNNNNNNNC CGAA AUGUUUCA	7320
1084	AAGACGGUC CUAUCGGC	3174	GCCGAUAG CUGAUGAG GNNNNNNNNC CGAA ACCGUCUU	7321
1087	ACGGUCCUA UCGGCUGU	3175	ACAGCCGA CUGAUGAG GNNNNNNNNC CGAA AGGACCGU	7322
1089	GGUCCUAUC GGCUGUCC	3176	GGACAGCC CUGAUGAG GNNNNNNNNC CGAA AUAGGACC	7323
1096	UCGGCUGUC CAUGAAAG	3177	CUUUCAUG CUGAUGAG GNNNNNNNNC CGAA ACAGCCGA	7324
1114	GAAGGCCUU CCCCUCCC	3178	GGGAGGGG CUGAUGAG GNNNNNNNNC CGAA AGGCCUUC	7325
1115	AAGGCCUUC CCCUCCCC	3179	GGGGAGGG CUGAUGAG GNNNNNNNNC CGAA AAGGCCUU	7326
1120	CUUCCCCUC CCCAGAAA	3180	UUUCUGGG CUGAUGAG GNNNNNNNNC CGAA AGGGGAAG	7327
1130	CCAGAAAUC GUAUGGUU	3181	AACCAUAC CUGAUGAG GNNNNNNNNC CGAA AUUUCUGG	7328
1133	GAAAUCGUA UGGUUAAA	3182	UUUAACCA CUGAUGAG GNNNNNNNNC CGAA ACGAUUUC	7329
1138	CGUAUGGUU AAAAGAUG	3183	CAUCUUUU CUGAUGAG GNNNNNNNNC CGAA ACCAUACG	7330
1139	GUAUGGUUA AAAGAUGG	210	CCAUCUUU CUGAUGAG GNNNNNNNNC CGAA AACCAUAC	4366
1150	AGAUGGCUC GCCUGCAA	3184	UUGCAGGC CUGAUGAG GNNNNNNNNC CGAA AGCCAUCU	7331
1162	UGCAACAUU GAAGUCUG	3185	CAGACUUC CUGAUGAG GNNNNNNNNC CGAA AUGUUGCA	7332
1168	AUUGAAGUC UGCUCGCU	3186	AGCGAGCA CUGAUGAG GNNNNNNNNC CGAA ACUUCAAU	7333
1173	AGUCUGCUC GCUAUUUG	3187	CAAAUAGC CUGAUGAG GNNNNNNNNC CGAA AGCAGACU	7334
1177	UGCUCGCUA UUUGGUAC	3188	GUACCAAA CUGAUGAG GNNNNNNNNC CGAA AGCGAGCA	7335
1179	CUCGCUAUU UGGUACAU	3189	AUGUACCA CUGAUGAG GNNNNNNNNC CGAA AUAGCGAG	7336
1180	UCGCUAUUU GGUACAUG	3190	CAUGUACC CUGAUGAG GNNNNNNNNC CGAA AAUAGCGA	7337
1184	UAUUUGGUA CAUGGCUA	3191	UAGCCAUG CUGAUGAG GNNNNNNNNC CGAA ACCAAAUA	7338
1192	ACAUGGCUA CUCAUUAA	3192	UUAAUGAG CUGAUGAG GNNNNNNNNC CGAA AGCCAUGU	7339
1195	UGGCUACUC AUUAAUUA	3193	UAAUUAAU CUGAUGAG GNNNNNNNNC CGAA AGUAGCCA	7340
1198	CUACUCAUU AAUUAUCA	3194	UGAUAAUU CUGAUGAG GNNNNNNNNC CGAA AUGAGUAG	7341
1199	UACUCAUUA AUUAUCAA	3195	UUGAUAAU CUGAUGAG GNNNNNNNNC CGAA AAUGAGUA	7342
1202	UCAUUAAUU AUCAAAGA	3196	UCUUUGAU CUGAUGAG GNNNNNNNNC CGAA AUUAAUGA	7343
1203	CAUUAAUUA UCAAAGAU	3197	AUCUUUGA CUGAUGAG GNNNNNNNNC CGAA AAUUAAUG	7344
1205	UUAAUUAUC AAAGAUGU	3198	ACAUCUUU CUGAUGAG GNNNNNNNNC CGAA AUAAUUAA	7345
1237	AGGGGACUA UACGAUCU	3199	AGAUCGUA CUGAUGAG GNNNNNNNNC CGAA AGUCCCCU	7346
1239	GGGACUAUA CGAUCUUG	3200	CAAGAUCG CUGAUGAG GNNNNNNNNC CGAA AUAGUCCC	7347
1244	UAUACGAUC UUGCUGGG	3201	CCCAGCAA CUGAUGAG GNNNNNNNNC CGAA AUCGUAUA	7348
1246	UACGAUCUU GCUGGGCA	3202	UGCCCAGC CUGAUGAG GNNNNNNNNC CGAA AGAUCGUA	7349
1256	CUGGGCAUA AAGCAGUC	3203	GACUGCUU CUGAUGAG GNNNNNNNNC CGAA AUGCCCAG	7350
1264	AAAGCAGUC AAGGCUAU	3204	AUAGCCUU CUGAUGAG GNNNNNNNNC CGAA ACUGCUUU	7351
1271	UCAAGGCUA UUUAAAAA	3205	UUUUUAAA CUGAUGAG GNNNNNNNNC CGAA AGCCUUGA	7352
1273	AAGGCUAUU UAAAAACC	3206	GGUUUUUA CUGAUGAG GNNNNNNNNC CGAA AUAGCCUU	7353
1274	AGGCUAUUU AAAAACCU	3207	AGGUUUUU CUGAUGAG GNNNNNNNNC CGAA AAUAGCCU	7354
1275	GGCUAUUUA AAAACCUC	3208	GAGGUUUU CUGAUGAG GNNNNNNNNC CGAA AAAUAGCC	7355
1283	AAAAACCUC ACUGCCAC	237	GUGGCAGU CUGAUGAG GNNNNNNNNC CGAA AGGUUUUU	4393
1293	CUGCCACUC UCAUUGUA	3209	UACAAUGA CUGAUGAG GNNNNNNNNC CGAA AGUGGCAG	7356
1295	GCCACUCUC AUUGUAAA	3210	UUUACAAU CUGAUGAG GNNNNNNNNC CGAA AGAGUGGC	7357
1298	ACUCUCAUU GUAAACGA	3211	ACGUUUAC CUGAUGAG GNNNNNNNNC CGAA AUGAGAGU	7358
1301	CUCAUUGUA AACGUGAA	3212	UUCACGUU CUGAUGAG GNNNNNNNNC CGAA ACAAUGAG	7359
1314	UGAAACCUC AGAUCUAC	3213	GUAGAUCU CUGAUGAG GNNNNNNNNC CGAA AGGUUUCA	7360
1319	CCUCAGAUC UACGAAAA	3214	UUUUCGUA CUGAUGAG GNNNNNNNNC CGAA AUCUGAGG	7361
1321	UCAGAUCUA CGAAAAGU	3215	ACUUUUCG CUGAUGAG GNNNNNNNNC CGAA AGAUCUGA	7362
1330	CGAAAAGUC CGUCUCCU	3216	AGGACACG CUGAUGAG GNNNNNNNNC CGAA ACUUUUCG	7363
1336	GUCCGUGUC CUCGCUUC	3217	GAAGCGAG CUGAUGAG GNNNNNNNNC CGAA ACACGGAC	7364
1339	CGUGUCCUC GCUUCCAA	3218	UUGGAAGC CUGAUGAG GNNNNNNNNC CGAA AGGACACG	7365
1343	UCCUCGCUU CCAAGCCC	3219	GGGCUUGG CUGAUGAG GNNNNNNNNC CGAA AGCGACCA	7366
1344	CCUCGCUUC CAAGCCCA	3220	UGGGCUUG CUGAUGAG GNNNNNNNNC CGAA AAGCGAGG	7367
1356	GCCCACCUC UCUAUCCG	3221	CGGAUAGA CUGAUGAG GNNNNNNNNC CGAA AGGUGGGC	7368
1358	CCACCUCUC UAUCCGCU	3222	AGCGGAUA CUGAUGAG GNNNNNNNNC CGAA AGAGGUGG	7369
1360	ACCUCUCUA UCCGCUGG	3223	CCAGCGGA CUGAUGAG GNNNNNNNNC CGAA AGAGAGGU	7370
1362	CUCUCUAUC CGCUGGGC	3224	GCCCAGCG CUGAUGAG GNNNNNNNNC CGAA AUAGAGAG	7371
1382	AGACAAGUC CUCACUUG	3225	CAAGUGAG CUGAUGAG GNNNNNNNNC CGAA ACUUGUCU	7372
1385	CAAGUCCUC ACUUGCAC	3226	GUGCAAGU CUGAUGAG GNNNNNNNNC CGAA AGGACUUG	7373
1389	UCCUCACUU GCACCGUG	3227	CACGGUGC CUGAUGAG GNNNNNNNNC CGAA AGUGAGGA	7374
1399	CACCGUGUA UGGCAUCC	3228	GGAUGCCA CUGAUGAG GNNNNNNNNC CGAA AGAGGGUG	7375
1406	UAUGGCAUG CCUCGGCC	3229	GGCCGAGG CUGAUGAG GNNNNNNNNC CGAA AUGCCAUA	7376
1410	GCAUCCCUC GGCCAACA	3230	UGUUGGCC CUGAUGAG GNNNNNNNNC CGAA AGGGAUGC	7377
1421	CCAACAAUC ACGUGGCU	3231	AGCCACGU CUGAUGAG GNNNNNNNNC CGAA AUUCUUGG	7378
1430	ACGUGGCUC UGGCACCC	3232	GGGUGCCA CUGAUGAG GNNNNNNNNC CGAA AGCCACGU	7379
1443	ACCCCUGUC ACCACAAU	3233	AUUGUGGU CUGAUGAG GNNNNNNNNC CGAA ACAGGGGU	7380
1452	ACCACAAUC ACUCCAAA	3234	UUUGGAGU CUGAUGAG GNNNNNNNNC CGAA AUUGUGGU	7381
1456	CAAUCACUC CAAAGAAA	3235	UUUCUUUG CUGAUGAG GNNNNNNNNC CGAA AGUGAUUG	7382
1468	AGAAACCUA UGACUUCU	3236	AGAAGUCA CUGAUGAG GNNNNNNNNC CGAA ACCUUUCU	7383
1474	GUAUGACUU CUGCACUG	3237	CAGUGCAG CUGAUGAG GNNNNNNNNC CGAA AGUCAUAC	7384
1475	UAUGACUUC UGCACUGA	3238	UCAGUGCA CUGAUGAG GNNNNNNNNC CGAA AAGUCUAU	7385
1495	UGAAGAAUC CUUUAUCC	3239	GGAUAAAG CUGAUGAG GNNNNNNNNC CGAA AUUCUUCA	7386
1498	AGAAUCCUU UAUCCUGG	3240	CCAGGAUA CUGAUGAG GNNNNNNNNC CGAA AGGAUUCA	7387
1499	GAAUCCUUU AUCCUGGA	3241	UCCAGGAU CUGAUGAG GNNNNNNNNC CGAA AAGGAUUC	7388
1500	AAUCCUUUA UCCUGGAU	3242	AUCCAGGA CUGAUGAG GNNNNNNNNC CGAA AAACCAUU	7389
1502	UCCUUUAUC CUGGAUCC	3243	GGAUCCAG CUGAUGAG GNNNNNNNNC CGAA AUAAAGGA	7390
1509	UCCUGGAUC CCAGCAGC	3244	GCUGCUGG CUGAUGAG GNNNNNNNNC CGAA AUCCAGGA	7391
1522	CAGCAACUU AGGAAACA	3245	UGUUUCCU CUGAUGAG GNNNNNNNNC CGAA AGUUGCUG	7392
1523	AGCAACUUA CCAAACAG	3246	CUGUUUCC CUGAUGAG GNNNNNNNNC CGAA AAGUUGCU	7393
1535	AACAGAAUU GAGAGCAU	280	AUGCUCUC CUGAUGAG GNNNNNNNNC CGAA AUUCUGUU	4436
1544	GAGAGCAUC UCUCAGCG	3247	CGCUGAGA CUGAUGAG GNNNNNNNNC CGAA AUGCUCUC	7394
1546	GAGCAUCUC UCAGCGCA	3248	UGCGCUCA CUGAUGAG GNNNNNNNNC CGAA AGAUGCUC	7395
1548	GCAUCUCUC AGCGCAUG	3249	CAUGCGCU CUGAUGAG GNNNNNNNNC CGAA AGAGAUGC	7396
1562	AUGACGGUC AUAGAAGG	3250	CCUUCUAU CUGAUGAG GNNNNNNNNC CGAA ACCGUCAU	7397
1565	ACGGUCAUA GAAGGAAC	3251	GUUCCUUC CUGAUGAG GNNNNNNNNC CGAA AUGACCGU	7398
1578	GAACAAAUA AGACGGUU	3252	AACCGUCU CUGAUGAG GNNNNNNNNC CGAA AUUUGUUC	7399
1586	AAGACGGUU AGCACAUU	3253	AAUGUGCU CUGAUGAG GNNNNNNNNC CGAA ACCGUCUU	7400
1587	AGACGGUUA GCACAUUG	3254	CAAUGUGC CUGAUGAG GNNNNNNNNC CGAA AACCGUCU	7401
1594	UAGCACAUU GGUGGUGG	3255	CCACCACC CUGAUGAG GNNNNNNNNC CGAA AUGUGCUA	7402
1609	GGCUGACUC UCAGACCC	3256	GGGUCUGA CUGAUGAG GNNNNNNNNC CGAA AGUCAGCC	7403
1611	CUGACUCUC AGACCCCU	3257	AGGGGUCU CUGAUGAG GNNNNNNNNC CGAA AGAGUCAG	7404
1625	CCUGGAAUC UACAGCUG	3258	CAGCUGUA CUGAUGAG GNNNNNNNNC CGAA AUUCCAGG	7405
1627	UGGAAUCUA CAGCUGCC	3259	GGCAGCUG CUGAUGAG GNNNNNNNNC CGAA AGAUUCCA	7406
1642	CCGGGCCUU CAAUAAAA	3260	UUUUAUUG CUGAUGAG GNNNNNNNNC CGAA AGGCCCGG	7407
1643	CGGGCCUUC AAUAAAAU	3261	AUUUUAUU CUGAUGAG GNNNNNNNNC CGAA AAGGCCCG	7408
1647	CCUUCAAUA AAAUAGGG	3262	CCCUAUUU CUGAUGAG GNNNNNNNNC CGAA AUUCAAGG	7409
1652	AAUAAAAUA GGGACUGU	3263	ACAGUCCC CUGAUGAG GNNNNNNNNC CGAA AUUUUAUU	7410
1673	AGAAACAUA AAAUUUUA	3264	UAAAAUUU CUGAUGAG GNNNNNNNNC CGAA AUGUUUCU	7411
1678	CAUAAAAUU UUAUGUCA	3265	UGACAUAA CUGAUGAG GNNNNNNNNC CGAA AUUUUAUG	7412
1679	AUAAAAUUU UAUGUCAC	3266	GUGACAUA CUGAUGAG GNNNNNNNNC CGAA AAUUUUAU	7413
1680	UAAAAUUUU AUGUCACA	3267	UGUGACAU CUGAUGAG GNNNNNNNNC CGAA AAAUUUUA	7414
1681	AAAAUUUUA UGUCACAG	3268	CUGUGACA CUGAUGAG GNNNNNNNNC CGAA AAAAUUUU	7415
1685	UUUUAUGUC ACAGAUGU	3269	ACAUCUGU CUGAUGAG GNNNNNNNNC CGAA ACAUAAAA	7416
1705	GAAUGGCUU UCACGUUU	3270	AAACGUCA CUGAUGAG GNNNNNNNNC CGAA AGCCAUUC	7417
1706	AAUGGCUUU CACGUUUC	3271	GAAACGUG CUGAUGAG GNNNNNNNNC CGAA AAGCCAUU	7418
1707	AUGGCUUUC ACGUUUCC	3272	GGAAACGU CUGAUGAG GNNNNNNNNC CGAA AAAGCCAU	7419
1712	UUUCACGUU UCCUUGGA	3273	UCCAAGGA CUGAUGAG GNNNNNNNNC CGAA ACGUGAAA	7420
1713	UUCACGUUU CCUUGGAA	3274	UUCCAAGG CUGAUGAG GNNNNNNNNC CGAA AACGUCAA	7421
1714	UCACGUUUC CUUGGAAA	3275	UUUCCAAG CUGAUGAG GNNNNNNNNC CGAA AAACGUGA	7422
1717	CGUUUCCUU GGAAAAGA	3276	UCUUUUCC CUGAUGAG GNNNNNNNNC CGAA AGGAAACG	7423
1756	GAAACUGUC CUGUGUGG	3277	CCACACAG CUGAUGAG GNNNNNNNNC CGAA ACAGUUUC	7424
1766	UGUGUGGUC AAUAAAUU	3278	AAUUUAUU CUGAUGAG GNNNNNNNNC CGAA ACCACACA	7425
1770	UGGUCAAUA AAUUCCUG	3279	CA55AAUU CUGAUGAG GNNNNNNNNC CGAA AUUGACCA	7426
1774	CAAUAAAUU CCUGUACA	3280	UGUACAGG CUGAUGAG GNNNNNNNNC CGAA AUUUAUUG	7427
1775	AAUAAAUUC CUGUACAG	3281	CUGUACAG CUGAUGAG GNNNNNNNNC CGAA AAUUUAUU	7428
1780	AUUCCUGUA CAGAGACA	3282	UGUCUCUG CUGAUGAG GNNNNNNNNC CGAA ACAGGAAU	7429
1790	AGAGACAUU ACCUGGAC	3283	AUCCAGGU CUGAUGAG GNNNNNNNNC CGAA AUGUCUCU	7430
1791	GAGACAUUA CCUGGAUU	3284	AAUCCAGG CUGAUGAG GNNNNNNNNC CGAA AAUGUCUC	7431
1799	ACCUGGAUU CUGCUACG	3285	CGUAGCAG CUGAUGAG GNNNNNNNNC CGAA AUCCAGGU	7432
1800	CCUGGAUUC UGCUACGG	3286	CCGUAGCA CUGAUGAG GNNNNNNNNC CGAA AAUCCAGG	7433
1805	AUUCUGCUA CGGACACU	3287	ACUGUCCG CUGAUGAG GNNNNNNNNC CGAA AGCAGAAU	7434
1814	CGGACAGUU AACAACAG	3288	CUGUUGUU CUGAUGAG GNNNNNNNNC CGAA ACUGUCCG	7435
1815	GGACAGUUA ACAACAGA	3289	UCUGUUGU CUGAUGAG GNNNNNNNNC CGAA AACUGUCC	7436
1836	UGCACCAUA GUAUCAGC	3290	GCUGAUAC CUGAUGAG GNNNNNNNNC CGAA AUGGUGCA	7437
1839	ACCAUAGUA UCAGCAAG	3291	CUUGCUGA CUGAUGAG GNNNNNNNNC CGAA ACUAUGGU	7438
1841	CAUAGUAUC AGCAAGCA	3292	UGCUUGCU CUGAUGAG GNNNNNNNNC CGAA AUACUAUG	7439
1866	CCACCACUC AAGAUUAC	3293	GUAAUCUU CUGAUGAG GNNNNNNNNC CGAA AGUGGUGG	7440
1872	CUCAAGAUU ACUCCAUC	3294	GAUGGAGU CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	7441
1873	UCAAGAUUA CUCCAUCA	3295	UGAUGGAG CUGAUGAG GNNNNNNNNC CGAA AAUCUUGA	7442
1876	AGAUUACUC CAUCACUC	3296	GAGUGAUG CUGAUGAG GNNNNNNNNC CGAA AGUAAGCU	7443
1880	UACUCCUAC ACUCUGAA	3297	UUCAGAGU CUGAUGAG GNNNNNNNNC CGAA AUGGAGUA	7444
1884	CCAUCACUC UGAACCUU	3298	AAGGUUCA CUGAUGAG GNNNNNNNNC CGAA AGUGAUGG	7445
1892	CUGAACCUU GUCAUCAA	3299	UUGAUGAC CUGAUGAG GNNNNNNNNC CGAA AGGUUCAG	7446
1895	AACCUUGUC AUCAAGAA	3300	UUCUUGAU CUGAUGAG GNNNNNNNNC CGAA ACAAGGUU	7447
1898	CUUGUCAUC AAGAACGU	3301	ACGUUCUU CUGAUGAG GNNNNNNNNC CGAA AUGACAAG	7448
1909	GAACGUGUC UCUAGAAG	3302	CUUCUAGA CUGAUGAG GNNNNNNNNC CGAA ACACGUUC	7449
1911	ACGUGUCUC UAGAAGAC	3303	GUCUUCUA CUGAUGAG GNNNNNNNNC CGAA AGACACGU	7450
1913	GUGUCUCUA GAAGACUC	3304	GAGUCUUC CUGAUGAG GNNNNNNNNC CGAA AGAGACAC	7451
1921	AGAAGACUC GGGCACCU	3305	AGGUGCCC CUGAUGAG GNNNNNNNNC CGAA AGUCUUCU	7452
1930	GGGCACCUA UGCGUGCA	3306	UGCACGCA CUGAUGAG GNNNNNNNNC CGAA AGGUGCCC	7453
1952	AGGAACAUA UACACAGG	3307	CCUGUGUA CUGAUGAG GNNNNNNNNC CGAA AUGUUCCU	7454
1954	GAACAUAUA CACAGGGG	3308	CCCCUGUG CUGAUGAG GNNNNNNNNC CGAA AUAUGUUC	7455
1970	GAAGACAUC CUUCGGAA	3309	UUCCGAAG CUGAUGAG GNNNNNNNNC CGAA AUGUCUUC	7456
1973	GACAUCCUU CGGAAGAC	3310	GUCUUCCG CUGAUGAG GNNNNNNNNC CGAA AGGAUGUC	7457
1974	ACAUCCUUC GGAAGACA	3311	UGUCUUCC CUGAUGAG GNNNNNNNNC CGAA AAGGAUGU	7458
1988	ACAGAAGUU C7CGUUAG	3312	CUAACGAG CUGAUGAG GNNNNNNNNC CGAA ACUUCUGU	7459
1989	CAGAAGUUC UCGUUAGA	3313	UCUAACGA CUGAUGAG GNNNNNNNNC CGAA AACUUCUG	7460
1991	GAAGUUCUC GUUAGAGA	3314	UCUCUAAC CUGAUGAG GNNNNNNNNC CGAA AGAACUUC	7461
1994	GUUCUCGUU AGAGAUUC	3315	GAAUCUCU CUGAUGAG GNNNNNNNNC CGAA ACGAGAAC	7462
1995	UUCUCGUUA GAGAUUCG	3316	CGAAUCUC CUGAUGAG GNNNNNNNNC CGAA AACGACAA	7463
2001	UUAGAGAUU CGGAAGCG	3317	CGCUUCCG CUGAUGAG GNNNNNNNNC CGAA AUCUCUAA	7464
2002	UAGAGAUUC GGAAGCGC	3318	GCGCUUCC CUGAUGAG GNNNNNNNNC CGAA AAUCUCUA	7465
2021	CACCUGCUU CAAAACCU	3319	AGGUUUUG CUGAUGAG GNNNNNNNNC CGAA AGCAGGUG	7466
2022	ACCUGCUUC AAAACCUC	3320	GAGGUUUU CUGAUGAG GNNNNNNNNC CGAA AAGCAGGU	7467
2030	CAAAACCUC AGUGACUA	3321	UAGUCACU CUGAUGAG GNNNNNNNNC CGAA AGGUUUUG	7468
2038	CAGUGACUA CGACCUCU	3322	AGACCUCG CUGAUGAG GNNNNNNNNC CGAA AGUCACUG	7469
2045	UACGAGGUC UCCAUCAG	3323	CUGAUGGA CUGAUGAG GNNNNNNNNC CGAA ACCUCGUA	7470
2047	CGAGGUCUC CAUCAGUG	3324	CACUGAUG CUGAUGAG GNNNNNNNNC CGAA AGACCUCG	7471
2051	GUCUCCAUC AGUGGCUC	3325	GAGCCACU CUGAUGAG GNNNNNNNNC CGAA AUGGAGAC	7472
2059	CAGUGGCUC UACGACCU	3326	AGGUCGUA CUGAUGAG GNNNNNNNNC CGAA AGCCACUG	7473
2061	GUGGCUCUA CGACCUUA	3327	UAAGGUCG CUGAUGAG GNNNNNNNNC CGAA AGAGCCAC	7474
2068	UACGACCUU AGACUGUC	3328	GACAGUAU CUGAUGAG GNNNNNNNNC CGAA AGGUCGUA	7475
2069	ACGACCUUA GACUGUCA	3329	UGACAGUC CUGAUGAG GNNNNNNNNC CGAA AAGGUCGU	7476
2076	UAGACUGUC AAGCUAGA	3330	UCUAGCUU CUGAUGAG GNNNNNNNNC CGAA ACAGUCUA	7477
2082	GUCAAGCUA GAGGUGUC	3331	GACACCUC CUGAUGAG GNNNNNNNNC CGAA AGCUUGAC	7478
2090	AGAGGUGUC CCCGCGCC	3332	GGCGCGGG CUGAUGAG GNNNNNNNNC CGAA ACACCUCU	7479
2100	CCGCGCCUC AGAUCACU	3333	AGUGAUCU CUGAUGAG GNNNNNNNNC CGAA AGGCGCGG	7480
2105	CCUCAGAUC ACUUGGUU	378	AACCAAGU CUGAUGAG GNNNNNNNNC CGAA AUCUGAGG	4534
2109	AGAUCACUU GGUUCAAA	3334	UUUGAACC CUGAUGAG GNNNNNNNNC CGAA AGUGAUCU	7481
2113	CACUUGGUU CAAAAACA	3335	UGUUUUUG CUGAUGAG GNNNNNNNNC CGAA ACCAAGUG	7482
2114	ACUUGGUUC AAAAACAA	3336	UUGUUUUU CUGAUGAG GNNNNNNNNC CGAA AACCAAGU	4537
2132	CACAAAAUA CAACAAGA	383	UCUUGUUG CUGAUGAG GNNNNNNNNC CGAA AUUUUGUG	4539
2150	CCGGGAAUU AUUUUAGG	3337	CCUAAAAU CUGAUGAG GNNNNNNNNC CGAA AUUCCCGG	7483
2151	CGGGAAUUA UUUUAGGA	3338	UCCUAAAA CUGAUGAG GNNNNNNNNC CGAA AAUUCCCG	7484
2153	GGAAUUAUU UUAGGACC	386	GGUCCUAA CUGAUGAG GNNNNNNNNC CGAA AUAAUUCC	4542
2154	GAAUUAUUU UAGGACCA	387	UGGUCCUA CUGAUGAG GNNNNNNNNC CGAA AAUAAUUC	4543
2155	AAUUAUUUU AGGACCAG	388	CUGGUCCU CUGAUGAG GNNNNNNNNC CGAA AAAUAAUU	4544
2156	AUUAUUUUA GGACCAGG	389	CCUGGUCC CUGAUGAG GNNNNNNNNC CGAA AAAAUAAU	4545
2179	CACGCUAUU UAUUGAAA	390	UUUCAAUA CUGAUGAG GNNNNNNNNC CGAA ACAGCGUG	4546
2180	ACGCUGUUU AUUGAAAG	391	CUUUCAAU CUGAUGAG GNNNNNNNNC CGAA AACAGCGU	4547
2181	CGCUGUUUA UUGAAAGA	392	UCUUUCAA CUGAUGAG GNNNNNNNNC CGAA AAACAGCG	4548
2183	CUGUUUAUU GAAAGAGU	393	ACUCUUUC CUGAUGAG GNNNNNNNNC CGAA AUAAACAG	4549
2192	GAAAGAGUC ACAGAGGA	3339	UCCUCUGU CUGAUGAG GNNNNNNNNC CGAA ACUCUUUC	7485
2213	GAGGGUGUC UAUAGGUG	3340	CACCUAUA CUGAUGAG GNNNNNNNNC CGAA ACACCCUC	7486
2215	GGGUGUCUA UAGGUGCC	3341	GGCACCUA CUGAUGAG GNNNNNNNNC CGAA AGACACCC	7487
2217	GUGUCUAUA GGUGCCGA	3342	UCGGCACC CUGAUGAG GNNNNNNNNC CGAA AUAGACAC	7488
2263	CGCAGCCUA CCUCACCG	3343	CGGUGAGG CUGAUGAG GNNNNNNNNC CGAA AGGCUGCG	7489
2267	GCCUACCUC ACCGUGCA	3344	UGCACGGU CUGAUGAG GNNNNNNNNC CGAA AGGUAGGC	7490
2284	AGGAACCUC AGACAAGU	3345	ACUUGUCU CUGAUGAG GNNNNNNNNC CGAA AGGUUCCU	7491
2293	AGACAAGUC AAACCUGG	3346	CCAGGUUU CUGAUGAG GNNNNNNNNC CGAA ACUUGUCU	7492
2309	GAGCUGAUC ACGCUCAC	3347	GUGAGCGU CUGAUGAG GNNNNNNNNC CGAA AUCAGCUC	7493
2315	AUCACGCUC ACGUGCAC	3348	GUGCACGU CUGAUGAG GNNNNNNNNC CGAA AGCGUGAU	7494
2342	GCGACCCUC UUUUGGCU	3349	AGCCAAAA CUGAUGAG GNNNNNNNNC CGAA AGGGUCGC	7495
2344	GACCCUCUU UUGGCUCC	3350	GGAGCCAA CUGAUGAG GNNNNNNNNC CGAA AGAGGGUC	7496
2345	ACCCUCUUU UGGCUCCU	3351	AGGAGCCA CUGAUGAG GNNNNNNNNC CGAA AAGAGGGU	7497
2346	CCCUCUUUU GGCUCCUU	3352	AAGGAGCC CUGAUGAG GNNNNNNNNC CGAA AAAGAGGG	7498
2351	UUUUGGCUC CUUCUAAC	3353	GUUAGAAG CUGAUGAG GNNNNNNNNC CGAA AGCCAAAA	7499
2354	UGGCUCCUU CUAACUCU	3354	AGAGUUAG CUGAUGAG GNNNNNNNNC CGAA AGGAGCCA	7500
2355	GGCUCCUUC UAACUCUC	3355	GAGAGUUA CUGAUGAG GNNNNNNNNC CGAA AAGGAGCC	7501
2357	CUCCUUCUA ACUCUCUU	3356	AAGAGAGU CUGAUGAG GNNNNNNNNC CGAA AGAAGGAG	7502
2361	UUCUAACUC UCUUCAUC	3357	GAUGAAGA CUGAUGAG GNNNNNNNNC CGAA AGUUAGAA	7503
2363	CUAACUCUC UUCAUCAG	3358	CUGAUGAA CUGAUGAG GNNNNNNNNC CGAA AGAGUUAG	7504
2365	AACUCUCUU CAUCAGAA	3359	UUCUGAUG CUGAUGAG GNNNNNNNNC CGAA AGAGACUU	7505
2366	ACUCUCUUC AUCAGAAA	3360	UUUCUGAU CUGAUGAG GNNNNNNNNC CGAA AAGAGAGU	7506
2369	CUCUUCAUC AGAAAACU	3361	AGUUUUCU CUGAUGAG GNNNNNNNNC CGAA AUGAAGAG	7507
2386	GAAGCGGUC UUCUUCCG	3362	CGGAAGAA CUGAUGAG GNNNNNNNNC CGAA ACCGCUUC	7508
2388	AGCGGUCUU CUUCCGAA	3363	UUCGGAAG CUGAUGAG GNNNNNNNNC CGAA AGACCGCU	7509
2389	GCGGUCUUC UUCCGAAG	3364	CUUCGGAA CUGAUGAG GNNNNNNNNC CGAA AAGACCGC	7510
2391	GGUCUUCUU CCGAAGUC	3365	UACUUCGG CUGAUGAG GNNNNNNNNC CGAA AGAAGACC	7511
2392	GUCUUCUUC CGAAGUAA	3366	UUACUUCG CUGAUGAG GNNNNNNNNC CGAA AAGAAGAC	7512
2399	UCCGAAGUA AACACAGA	3367	UCUGUCUU CUGAUGAG GNNNNNNNNC CGAA ACUUCGGA	7513
2410	GACAGACUA CCUGUCAA	3368	UUGACAGG CUGAUGAG GNNNNNNNNC CGAA AGUCUGUC	7514
2416	CUACCUGUC AAUCAUUA	3369	UAAUGAUU CUGAUGAG GNNNNNNNNC CGAA ACAGGUAG	7515
2420	CUGUCAAUC AUUAUGGA	3370	UCCAUCCU CUGAUGAG GNNNNNNNNC CGAA AUUGACAG	7516
2423	UCAAUCAUU AUGGACCC	3371	GGGUCCAU CUGAUGAG GNNNNNNNNC CGAA AUGAUUGA	7517
2424	CAAUCAUUA UGGACCCA	3372	UGGGUCCA CUGAUGAG GNNNNNNNNC CGAA AAUGAUUG	7518
2441	GAUGAAGUU CCCCUGGA	3373	UCCAGGGG CUGAUGAG GNNNNNNNNC CGAA ACUUCAUC	7519
2442	AUGAAGUUC CCCUGGAU	3374	AUCCAGGG CUGAUGAG GNNNNNNNNC CGAA AACUUCAU	7520
2473	GCUGCCCUA UGAUGCCA	3375	UGGCAUCA CUGAUGAG GNNNNNNNNC CGAA AGGGCAGC	7521
2494	GUGGGAGUU UGCACGGG	3376	CCCGUGCA CUGAUGAG GNNNNNNNNC CGAA ACUCCCAC	7522
2495	UGGGAGUUU GCACGGGA	3377	UCCCGUGC CUGAUGAG GNNNNNNNNC CGAA AACUCCCA	7523
2516	CUGAAACUA GGCAAAUC	3378	GAUUUGGC CUGAUGAG GNNNNNNNNC CGAA AGUUUCAG	7524
2524	AGGCAAAUC GCUCGGAA	3379	UUCCGAGC CUGAUGAG GNNNNNNNNC CGAA AUUUGCCU	7525
2528	AAAUCGCUC GGAAGAGG	3380	CCUCUUCC CUGAUGAG GNNNNNNNNC CGAA AGCGAUUU	7526
2541	GAGGGGCUU UUGGGAAA	3381	UUUCCCAA CUGAUGAG GNNNNNNNNC CGAA AGCCCCUC	7527
2542	AGGGGCUUU UGGGAAAG	3382	CUUUCCCA CUGAUGAG GNNNNNNNNC CGAA AAGCCCCU	7528
2543	GGGGCUUUU GGGAAAGU	3383	ACUUUCCC CUGAUGAG GNNNNNNNNC CGAA AAAGCCCC	7529
2552	GGGAAAGUC GUUCAAGC	3384	GCUUGAAC CUGAUGAG GNNNNNNNNC CGAA ACUUUCCC	7530
2555	AAACUCGUU CAAGCCUC	3385	GAGGCUUG CUGAUGAG GNNNNNNNNC CGAA ACGACUUU	7531
2556	AAGUCGUUC AAGCCUCU	3386	AGAGGCUU CUGAUGAG GNNNNNNNNC CGAA AACGACUU	7532
2563	UCAAGCCUC UGCAUUUG	3387	CAAAUGCA CUGAUGAG GNNNNNNNNC CGAA AGGCUUGA	7533
2569	CUCUGCAUU UGGCAUUA	3388	UAAUGCCA CUGAUGAG GNNNNNNNNC CGAA AUGCAGAG	7534
2570	UCUGCAUUU GGCAUUAA	3389	UUAAUGCC CUGAUGAG GNNNNNNNNC CGAA AAUCCAGA	7535
2576	UUUGGCAUU AAGAAAUC	457	GAUUUCUU CUGAUGAG GNNNNNNNNC CGAA AUCGCAAA	4613
2577	UUGGCAUUA AGAAAUCA	458	UGAUUUCU CUGAUGAG GNNNNNNNNC CGAA AAUGCCAA	4614
2584	UAAGAAAUC ACCCACCU	3390	AGGUGGGU CUGAUGAG GNNNNNNNNC CGAA AUUUCUUA	7536
2617	GAAGAUGUU GAAAGAGG	3391	CCUCUUUC CUGAUGAG GNNNNNNNNC CGAA ACAUCUUC	7537
2644	CAGUGAGUA CAAAGCUC	3392	GAGCUUUG CUGAUGAG GNNNNNNNNC CGAA ACUCACUG	7538
2652	ACAAAGCUC UGUUGACC	3393	GGUCAUCA CUGAUGAG GNNNNNNNNC CGAA AGCUUUGU	7539
2666	ACCGAACUC AAGAUCUU	3394	AAGAUCUU CUGAUGAG GNNNNNNNNC CGAA AGUUCGGU	7540
2672	CUCAAGAUC UUGACCCA	3395	UGGGUCAA CUGAUGAG GNNNNNNNNC CGAA AUCUUGAG	7541
2674	CAAGAUCUU GACCCACA	3396	UGUGGGUC CUGAUGAG GNNNNNNNNC CGAA AGAUCUUG	7542
2684	ACCCACAUC GGCCAUCA	3397	UGAUGGCC CUGAUGAG GNNNNNNNNC CGAA AUCUGGGU	7543
2691	UCGGCGAUC AUCUGAAU	3398	AUUCAGAU CUGAUGAG GNNNNNNNNC CGAA AUGUCCGA	7544
2694	GCCAUCAUC UGAAUGUG	3399	CACAUUCA CUGAUGAG GNNNNNNNNC CGAA AUGGUGGC	7545
2705	AAUGUGGUU AACCUCCU	3400	AGGAGGUU CUGAUGAG GNNNNNNNNC CGAA ACCACAUU	7546
2706	AUGUGGUUA ACCUCCUG	3401	ACGGAGGU CUGAUGAG GNNNNNNNNC CGAA ACCAACAU	7547
2711	GUUAACCUC CUGGGAGC	3402	GCUCCCAG CUGAUGAG GNNNNNNNNC CGAA AACCUAAC	7548
2742	GAGGGCCUC UGACGGUG	470	CACCAUCA CUGAUGAG GNNNNNNNNC CGAA AGGCCCUC	4626
2753	AUGGUGAUC GUGGAAUA	3403	UAUUCCAC CUGAUGAG GNNNNNNNNC CGAA AUCACCAU	7549
2761	CGUGGAAUA CUGCAAAU	3404	AUUUGCAG CUGAUGAG GNNNNNNNNC CGAA AUCACACG	7550
2770	CUGCAAAUA CGGAAACC	3405	GGUUUCCG CUGAUGAG GNNNNNNNNC CGAA AUUCGCAG	7551
2782	AAACCUGUC CAACUACC	3406	GGUAGUUG CUGAUGAG GNNNNNNNNC CGAA AUUUGUUU	7552
2788	GUCCAACUA CCUCAAGA	3407	UCUUGAGG CUGAUGAG GNNNNNNNNC CGAA ACAGGGAC	7553
2792	AACUACCUC AAGAGCAA	479	UUGCUCUU CUGAUGAG GNNNNNNNNC CGAA AGUUAGUU	4635
2809	ACGUGACUU AUUCUGUC	3408	GACAGAAU CUGAUGAG GNNNNNNNNC CGAA AGGUACGU	7554
2810	CGUCACUUA CCGUGUCU	3409	AGACAGAA CUGAUGAG GNNNNNNNNC CGAA AGUCCACG	7555
2812	UGACUUAUU CUGUCUCA	3410	UGAGACAG CUGAUGAG GNNNNNNNNC CGAA AUAAGUCA	7556
2813	GACUUAUUC UGUCUCAA	3411	UUGAGACA CUGAUGAG GNNNNNNNNC CGAA AUAAAGUC	7557
2817	UAUUCUGUC UCAACAAG	3412	CUUGUUGA CUGAUGAG GNNNNNNNNC CGAA ACAGAAUA	7558
2819	UUCUGUCUC AACAUGGA	3413	UCCUUGUU CUGAUGAG GNNNNNNNNC CGAA ACAGAGAA	7559
2836	CGCAGCCUU GCAUAUGG	3414	CCAUAUGC CUGAUGAG GNNNNNNNNC CGAA AGGCUGCG	7560
2841	CCUUGCAUA UGGAGCUC	3415	GAGCUCCA CUGAUGAG GNNNNNNNNC CGAA AUGCAAGG	7561
2849	AUGGAGCUC AAGAAAGA	3416	UCUUUCUU CUGAUGAG GNNNNNNNNC CGAA AGCUCCAU	7562
2900	CCCCGCCUA GACAGUGU	3417	AGAGUGUC CUGAUGAG GNNNNNNNNC CGAA AGGCGGGG	7563
2909	GACAGUGUC AGCAGCUC	3418	GAGCUGCU CUGAUGAG GNNNNNNNNC CGAA ACACUGUC	7564
2917	CAGCAGCUC AAGUGUCA	3419	UGACACUU CUGAUGAG GNNNNNNNNC CGAA AGCUGCUG	7565
2924	UCAAGUGUC ACCAGCUC	3420	GAGCUGGU CUGAUGAG GNNNNNNNNC CGAA ACACUUGA	7566
2932	CACCAGCUC CAGCUUCC	3421	GGAAGCUG CUGAUGAG GNNNNNNNNC CGAA AGCUGGUG	7567
2938	CUCCAGCUU CCCUGAAG	3422	CUUCAGGG CUGAUGAG GNNNNNNNNC CGAA AGCUGGAG	7568
2939	UCCAGCUUC CCUGAAGA	3423	UCUUCAGG CUGAUGAG GNNNNNNNNC CGAA AAGCUGGA	7569
2982	ACGAGGAUU ACAGUGAG	3424	CUCACUGU CUGAUGAG GNNNNNNNNC CGAA AUCCUCGU	7570
2983	CGAGGAUUA CAGUGAGA	3425	UCUCACUG CUGAUGAG GNNNNNNNNC CGAA AAUCCUCG	7571
2993	AGUGAGAUC UCCAAGCA	3426	UGCUUGGA CUGAUGAG GNNNNNNNNC CGAA AUCUCACU	7572
2995	UGAGAUCUC CAAGCAGC	3427	GCUGCUUG CUGAUGAG GNNNNNNNNC CGAA AGAUCUCA	7573
3008	CAGCCCCUC ACCAUGGA	3428	UCCAUGGU CUGAUGAG GNNNNNNNNC CGAA AGGGGCUG	7574
3026	GACCUGAUU UCCUACAG	3429	GUCUAGGA CUGAUGAG GNNNNNNNNC CGAA AUCAGGUC	7575
3027	ACCUGAUUU CCUACAGU	3430	ACUGUAGG CUGAUGAG GNNNNNNNNC CGAA AAUCAGGU	7576
3028	CCUGAUUUC CUACAGUU	3431	AACUGUAG CUGAUGAG GNNNNNNNNC CGAA AAAUCAGG	7577
3031	GAUUUCCUA CAGUUUCC	3432	GGAAACUG CUGAUGAG GNNNNNNNNC CGAA AGGAAAUC	7578
3036	CCUACAGUU UCCAAGUG	3433	CACUUGGA CUGAUGAG GNNNNNNNNC CGAA ACUGUAGG	7579
3037	CUACAGUUU CCAAGUGG	3434	CCACUUGG CUGAUGAG GNNNNNNNNC CGAA AACUGUAG	7580
3038	UACAGUUUC CAAGUGGC	3435	GCCACUUG CUGAUGAG GNNNNNNNNC CGAA AAACUGUA	4675
3061	CAUGGAGUU UCUGUCCU	3436	AGGACAGA CUGAUGAG GNNNNNNNNC CGAA ACUCCAUG	7581
3062	AUGGAGUUU CUGUCCUC	3437	GAGGACAG CUGAUGAG GNNNNNNNNC CGAA AACUCCAU	7582
3063	UGGAGUUUC UGUCCUCC	3438	GGAGGACA CUGAUGAG GNNNNNNNNC CGAA AAACUCCA	7583
3067	GUUUUUGUC CUCCAGAA	3439	UUCUGGAG CUGAUGAG GNNNNNNNNC CGAA ACAGAAAC	7584
3070	UCUGUCCUC CAGAAAGU	3440	ACUUUCUG CUGAUGAG GNNNNNNNNC CGAA AGGACAGA	7585
3083	AAGUGCAUU CAUCGGGU	526	UCCCGAUG CUGAUGAG GNNNNNNNNC CGAA AUGCACUU	4682
3084	AGUGCAUUC AUCGGGAC	527	GUCCCGAU CUGAUGAG GNNNNNNNNC CGAA AAUGCACU	4683
3087	GCAUUCAUC GGGACCUG	528	CAGGUCCC CUGAUGAG GNNNNNNNNC CGAA AUGAAUGC	4684
3110	AGAAACAUC CUUUUAUC	3441	GAUAAAAG CUGAUGAG GNNNNNNNNC CGAA AUGUUUCU	4685
3113	AACAUCCUU UUAUCUGA	3442	UCAGAUAA CUGAUGAG GNNNNNNNNC CGAA AGGAUGUU	7586
3114	ACAUCCUUU UAUCUGAG	3443	CUCAGAUA CUGAUGAG GNNNNNNNNC CGAA AAGGAUGU	7587
3115	CAUCCUUUU AUCUGAGA	3444	UCUCAGAU CUGAUGAG GNNNNNNNNC CGAA AAAGGAUG	7588
3116	AUCCUUUUA UCUGAGAA	3445	UUCUCAGA CUGAUGAG GNNNNNNNNC CGAA AAAAGGAU	7589
3118	CCUUUUAUC UGAGAACA	3446	UGUUCUCA CUGAUGAG GNNNNNNNNC CGAA AUAAAAGG	7590
3140	GUGAAGAUU UGCGACUU	3447	AAGUCGCA CUGAUGAG GNNNNNNNNC CGAA AUCUUCAC	7591
3141	UGAAGAUUU GCGACUUU	3448	AAAGUCGC CUGAUGAG GNNNNNNNNC CGAA AAUCUUCA	7592
3148	UUGCGACUU UGGCCUGG	3449	CCAGGCCA CUGAUGAG GNNNNNNNNC CGAA AGUCGCAA	7593
3149	UGCGACUUU GGCCUGGC	3450	GCCAGGCC CUGAUGAG GNNNNNNNNC CGAA AAGUCGCA	7594
3165	CCCGGGAUA UUUAUAAG	542	CUUAUAAA CUGAUGAG GNNNNNNNNC CGAA AUCCCGGG	4698
3167	CGGGAUAUU UAUAAGAA	543	UUCUUAUA CUGAUGAG GNNNNNNNNC CGAA AUAUCCCG	4699
3168	GGGAUAUUU AUAAGAAC	544	GUUCUUAU CUGAUGAG GNNNNNNNNC CGAA AAUAUCCC	4700
3169	GGAUAUUUA UAAGAACC	545	GGUUCUUA CUGAUGAG GNNNNNNNNC CGAA AAAUAUCC	4701
3171	AUAUUUAUA AGAACCCU	3451	AGGGUUCU CUGAUGAG GNNNNNNNNC CGAA AUAAAUAU	7595
3183	ACCCUGAUU AUGUGAGG	3452	CCUCACAU CUGAUGAG GNNNNNNNNC CGAA AUCAGGGU	7596
3184	CCCUGUAAU UGUGAGGA	3453	UCCUCACA CUGAUGAG GNNNNNNNNC CGAA AAUCAGGG	7597
3201	GAGGAGAUA CUCGACUU	3454	AAGUCGAG CUGAUGAG GNNNNNNNNC CGAA AUCUCCUC	7598
3204	GAGAUACUC GACUUCCC	3455	GGGAAGUC CUGAUGAG GNNNNNNNNC CGAA AGUAUCUC	7599
3209	ACUCGACUU CCCCUAAA	3456	UUUAGGGG CUGAUGAG GNNNNNNNNC CGAA AGUCGAGU	7600
3210	CUCGACUUC CCCUAAAA	3457	UUUUAGGG CUGAUGAG GNNNNNNNNC CGAA AAGUCGAG	7601
3215	CUUCCCCUA AAAUGGAU	3458	AUCCAUUU CUGAUGAG GNNNNNNNNC CGAA AGGGGAAG	7602
3228	GGAUGGCUC CUGAAUCC	3459	GGAUUCAG CUGAUGAG GNNNNNNNNC CGAA AGCCAUCC	7603
3235	UCCAGAAUC CAUCUUUG	3460	CAAAGAUG CUGAUGAG GNNNNNNNNC CGAA AUUCAGGA	7604
3239	GAAUCCAUC UUUGACAA	3461	UUGUCAAA CUGAUGAG GNNNNNNNNC CGAA AUGGAUUC	7605
3241	AUCCAUCUU UGACAAGG	3462	CCUUGUCA CUGAUGAG GNNNNNNNNC CGAA AGAUGGAU	7606
3242	UCCAUCUUU GACAAGGU	3463	ACCUUGUC CUGAUGAG GNNNNNNNNC CGAA AAGAUGGA	7607
3251	GACAAGGUC UACAGCAC	3464	GUGCUGUA CUGAUGAG GNNNNNNNNC CGAA ACCUUGUC	7608
3253	CAAGGUCUA CAGCACCA	3465	UGGUGCUG CUGAUGAG GNNNNNNNNC CGAA AGACCUUG	7609
3277	UGUGUGGUC CUAUGGCG	3466	CGCCAUAG CUGAUGAG GNNNNNNNNC CGAA ACCACACA	7610
3280	GUGGUCCUA UGGCGUGU	3467	ACACGCCA CUGAUGAG GNNNNNNNNC CGAA AGGACCAC	7611
3289	UGGCGUGUU GCUGUGGG	3468	CCCACAGC CUGAUGAG GNNNNNNNNC CGAA ACACGCCA	7612
3302	UGGGAGAUC UUCUCCUU	3469	AAGGAGAA CUGAUGAG GNNNNNNNNC CGAA AUCUCCCA	7613
3304	GGAGAUCUU CUCCUCAG	3470	CUAAGGAG CUGAUGAG GNNNNNNNNC CGAA AGAUCUCC	7614
3305	GAGAUCUUC UCCUUAGG	3471	CCUAAGGA CUGAUGAG GNNNNNNNNC CGAA AAGAUCUC	7615
3307	GAUCUUCUC CUUAGGGG	3472	CCCCUAAG CUGAUGAG GNNNNNNNNC CGAA AGAAGAUC	7616
3310	CUUCUCCUU AGGGGGUU	3473	AACCCCCU CUGAUGAG GNNNNNNNNC CGAA AGGAGAAG	7617
3311	UUCUCCUUA GGGGGUUC	3474	GAACCCCC CUGAUGAG GNNNNNNNNC CGAA AAGGAGAA	7618
3318	UAGGGGGUU CUCCAUAC	3475	GUAUGGAG CUGAUGAG GNNNNNNNNC CGAA ACCCCCUA	7619
3319	AGGGGGUUC UCCAUACC	3476	GGUAUGGA CUGAUGAG GNNNNNNNNC CGAA AACCCCCU	7620
3321	GGGGUUCUC CAUACCCA	3477	UGGGUAUG CUGAUGAG GNNNNNNNNC CGAA AGAACCCC	7621
3325	UUCUCCAUA CCCAGGAG	3478	CUCCUGGG CUGAUGAG GNNNNNNNNC CGAA AUGGAGAA	7622
3352	UGAAGACUU CUGUAGCC	3479	GGCUGCAG CUGAUGAG GNNNNNNNNC CGAA AGUCUUCA	7623
3353	GAAGACUUC UGCAGCCG	3480	CGGCUGCA CUGAUGAG GNNNNNNNNC CGAA AAGUCUUC	7624
3397	CCCGGAGUA UGCCACAC	3481	GUGUGGCA CUGAUGAG GNNNNNNNNC CGAA AGUCCGGG	7625
3413	CCUGAAAUC UACCAAAU	3482	AUUUGGUA CUGAUGAG GNNNNNNNNC CGAA AUUUCAGG	7626
3415	UGAAAUCUA CCAAAUCA	3483	UGAUUUGG CUGAUGAG GNNNNNNNNC CGAA AGAUUUCA	7627
3422	UACCAAAUC AUGUUGGA	3484	UCCAACAU CUGAUGAG GNNNNNNNNC CGAA AUUUGGUA	7628
3427	AAUCAUGUU GGAUUGCU	3485	AGCAAUCC CUGAUGAG GNNNNNNNNC CGAA AGAUGAUU	7629
3432	UGUUGGAUU GCUGGCAC	3486	GUGCCAGC CUGAUGAG GNNNNNNNNC CGAA AUCCAACA	7630
3466	GCCCCGGUU UGCUGAAC	3487	GUUCAGCA CUGAUGAG GNNNNNNNNC CGAA ACCGGGGC	7631
3467	CCCCGGUUU GCUGAACU	3488	AGUUCAGC CUGAUGAG GNNNNNNNNC CGAA AACCGGGG	7632
3476	GCUGAACUU GUGGAGAA	3489	UUCUCCAC CUGAUGAG GNNNNNNNNC CGAA ACUUCAGC	7633
3488	GAGAAACUU GGUGACCU	3490	AGGUCACC CUGAUGAG GNNNNNNNNC CGAA AGUUUCUC	7634
3500	GACCUGCUU CAAGCCAA	3491	UUGGCUUG CUGAUGAG GNNNNNNNNC CGAA AGCAGGUC	7635
3501	ACCUGCUUC AAGCCAAC	3492	GUUGGCUU CUGAUGAG GNNNNNNNNC CGAA AAGCAGGU	7636
3512	GCCAACGUC CAACAGGA	3493	UCCUGUUG CUGAUGAG GNNNNNNNNC CGAA ACGUUGGC	7637
3531	GGAAAGAUU ACAUCCCC	3494	GGGGAUGU CUGAUGAG GNNNNNNNNC CGAA AUCUUUCC	7638
3532	GAAAGAUUA CAUCCCCC	3495	GGGGGAUG CUGAUGAG GNNNNNNNNC CGAA AAUCUUUC	7639
3536	GAUUACAUC CCCCUCAA	3496	UUGAGGGG CUGAUGAG GNNNNNNNNC CGAA AUGUAAUC	7640
3542	AUCCCCCUC AAUGCCAU	3497	AUGGCAUU CUGAUGAG GNNNNNNNNC CGAA AGGGGGAU	7641
3551	AAUGCCAUA CUGACUAG	3498	CUAGUCAG CUGAUGAG GNNNNNNNNC CGAA AUGGCAUU	7642
3558	UACAGACUA GAAACAGU	3499	ACUGUUUC CUGAUGAG GNNNNNNNNC CGAA AGUCAGUA	7643
3567	GAAACAGUA GCUUCACA	3500	UGUGAAGC CUGAUGAG GNNNNNNNNC CGAA ACUGUUUC	7644
3571	CAGUAGCUU CACAUACU	3501	AGUAUGUG CUGAUGAG GNNNNNNNNC CGAA AGCUACUG	7645
3572	AGUAGCUUC ACAUACUC	3502	GAGUAUGU CUGAUGAG GNNNNNNNNC CGAA AAGCUACU	7646
3577	CUUCACAUA CUCGACCC	3503	GGGUCGAG CUGAUGAG GNNNNNNNNC CGAA AUGUGAAG	7647
3580	CACAUACUC GACCCCCA	3504	UGGGGGUC CUGAUGAG GNNNNNNNNC CGAA AGUCUGUG	7648
3592	CCCCACCUU CUCUGAGG	3505	CCUCAGAG CUGAUGAG GNNNNNNNNC CGAA AGGUGGGG	7649
3593	CCCACCUUC UCUGAGGA	3506	UCCUCAGA CUGAUGAG GNNNNNNNNC CGAA AAGGUGGG	7650
3595	CACCUUCUC UGAGGACC	3507	GGUCCUCA CUGAUGAG GNNNNNNNNC CGAA AGAAGGUG	7651
3605	GAGGACCUU UUCAAGGA	3508	UCCUUGAA CUGAUGAG GNNNNNNNNC CGAA AGGUCCUC	7652
3606	AGGACCUUU UCAAGGAC	3509	GUCCUUGA CUGAUGAG GNNNNNNNNC CGAA AAGGUCCU	7653
3607	GGACCUUUU CAAGGACG	3510	CGUCCUUG CUGAUGAG GNNNNNNNNC CGAA AAAGGUCC	7654
3608	GACCUUUUC AAGGACGG	3511	CCGUCCUU CUGAUGAG GNNNNNNNNC CGAA AAAAGGUC	7655
3619	GGACGGCUU UGCAGAUC	3512	GAUCUGCA CUGAUGAG GNNNNNNNNC CGAA AGCCGUCC	7656
3620	GACGGCUUU GCAGAUCC	3513	GGAUCUGC CUGAUGAG GNNNNNNNNC CGAA AAGCCGUC	7657
3627	UUGCAGAUC CACAUUUU	3514	AAAAUGUG CUGAUGAG GNNNNNNNNC CGAA AUCUGCAA	7658
3633	AUCCACAUU UUCAUUCC	3515	GGAAUGAA CUGAUGAG GNNNNNNNNC CGAA AUGUGGAU	7659
3634	UCCACAUUU UCAUUCCG	3516	CGGAAUGA CUGAUGAG GNNNNNNNNC CGAA AAUGUGGA	7660
3635	CCACAUUUU CAUUCCGG	3517	CCGGAAUG CUGAUGAG GNNNNNNNNC CGAA AAAUGUGG	7661
3636	CACAUUUUC AUUCCGGA	3518	UCCGGAAU CUGAUGAG GNNNNNNNNC CGAA AAAAUGUG	7662
3639	AUUUUCAUU CCGGAAGC	3519	GCUUCCGG CUGAUGAG GNNNNNNNNC CGAA AUGAAAAU	7663
3640	UUUUCAUUC CGGAAGCU	3520	AGCUUCCG CUGAUGAG GNNNNNNNNC CGAA AAUGAAAA	7664
3649	CGGAAGCUC UGAUGAUG	3521	CAUCAUCA CUGAUGAG GNNNNNNNNC CGAA AGCUUCCG	7665
3664	UGUGAGAUA UGUAAACG	3522	CGUUUACA CUGAUGAG GNNNNNNNNC CGAA AUCUCACA	7666
3668	AGAUAUGUA AACGCUUU	3523	AAAGCGUU CUGAUGAG GNNNNNNNNC CGAA ACAUAUCU	7667
3675	UAAACGCUU UCAAAUUC	3524	GAAUUUGA CUGAUGAG GNNNNNNNNC CGAA AGCGUUUA	7668
3676	AAACGCUUU CAAAUUCA	3525	UGAAUUUG CUGAUGAG GNNNNNNNNC CGAA AAGCGUUU	7669
3677	AACGCUUUC AAAUUCAU	3526	AUGAAUUU CUGAUGAG GNNNNNNNNC CGAA AAAGCGUU	7670
3682	UUUCAAAUU CAUGAGCC	3527	GGCUCAUG CUGAUGAG GNNNNNNNNC CGAA AUUUGAAA	7671
3683	UUCAAAUUC AUGAGCCU	3528	AGGCUCAU CUGAUGAG GNNNNNNNNC CGAA AAUUUGAA	7672
3701	GAAAGAAUC AAAACCUU	637	AAGGUUUU CUGAUGAG GNNNNNNNNC CGAA AUUCUUUC	4793
3709	CAAAACCUU UGAGGAGC	3529	GCUCCUCA CUGAUGAG GNNNNNNNNC CGAA AGGUUUUG	7673
3710	AAAACCUUU GAGGAGCU	3530	AGCUCCUC CUGAUGAG GNNNNNNNNC CGAA AAGGUUUU	7674
3719	GAGGAGCUU UCACCGAA	3531	UUCGGUGA CUGAUGAG GNNNNNNNNC CGAA AGCUCCUC	7675
3720	AGGAGCUUU CACCGAAC	3532	GUUCGGUG CUGAUGAG GNNNNNNNNC CGAA AAGCUCCU	7676
3721	GGAGCUUUC ACCGAACU	3533	AGUUCGGU CUGAUGAG GNNNNNNNNC CGAA AAAGCUCC	7677
3730	ACCGAACUC CACCUCCA	3534	UGGAGGUG CUGAUGAG GNNNNNNNNC CGAA AGUUCGGU	7678
3736	CUCCACCUC CAUGUUUG	3535	CAAACAUG CUGAUGAG GNNNNNNNNC CGAA AGGUGGAG	7679
3742	CUCCAUGUU UGAGGACU	3536	AGUCCUCA CUGAUGAG GNNNNNNNNC CGAA ACAUGGAG	7680
3743	UCCAUGUUU GAGGACUA	3537	UAGUCCUC CUGAUGAG GNNNNNNNNC CGAA AACAUGGA	7681
3751	UGAGGACUA UCAGCUGG	3538	CCAGCUGA CUGAUGAG GNNNNNNNNC CGAA AGUCCUCA	7682
3753	AGGACUAUC AGCUGGAC	3539	GUCCAGCU CUGAUGAG GNNNNNNNNC CGAA AUAGUCCU	7683
3765	UGGACACUA GCACUCUG	3540	CAGAGUGC CUGAUGAG GNNNNNNNNC CGAA AGUGUCCA	7684
3771	CUAGCACUC UGCUGGGC	3541	GCCCAGCA CUGAUGAG GNNNNNNNNC CGAA AGUGCUAG	7685
3781	GCUGGGCUC CCCCUUGC	3542	GCAAGGGG CUGAUGAG GNNNNNNNNC CGAA AGCCCAGC	7686
3787	CUCCCCCUU GCUGAAGC	3543	GCUUCAGC CUGAUGAG GNNNNNNNNC CGAA AGGGGGAG	7687
3799	GAAGCGGUU CACCUGGA	3544	UCCAGGUG CUGAUGAG GNNNNNNNNC CGAA ACCGCUUC	7688
3800	AAGCGGUUC ACCUGGAC	3545	GUCCAGGU CUGAUGAG GNNNNNNNNC CGAA AACCGCUU	7689
3829	CAAGGCCUC CAUGAAGA	3546	UCUUCAUG CUGAUGAG GNNNNNNNNC CGAA AGGCCUUG	7690
3839	AUGAAGAUA GACUUGAG	3547	CUCAAGUC CUGAUGAG GNNNNNNNNC CGAA AUCUUCAU	7691
3844	GAUAGACUU GAGAAUAG	3548	CUAUUCUC CUGAUGAG GNNNNNNNNC CGAA AGUCUAUC	7692
3851	UUGAGAAUA GCGAGUAA	3549	UUACUCGC CUGAUGAG GNNNNNNNNC CGAA AUUCUCAA	7693
3858	UAGCGAGUA AAAGCAAG	3550	CUUGCUUU CUGAUGAG GNNNNNNNNC CGAA ACUCGCUA	7694
3878	GCGGGACUU UCCGAUCU	3551	AGAUCGGA CUGAUGAG GNNNNNNNNC CGAA AGUCCCGC	7695
3879	CGGGACUUU CCGAUCUG	3552	CAGAUCGG CUGAUGAG GNNNNNNNNC CGAA AAGUCCCG	7696
3880	GGGACUUUC CGAUCUGC	3553	GCAGAUCG CUGAUGAG GNNNNNNNNC CGAA AAAGUCCC	7697
3885	UUUCCGAUC UGCCGAGG	3554	CCUCGGCA CUGAUGAG GNNNNNNNNC CGAA AUCGGAAA	7698
3901	GCCCAGCUU CUGCUUCU	3555	AGAAGCAG CUGAUGAG GNNNNNNNNC CGAA AGCUGGGC	7699
3902	CCCAGCUUC UGCUUCUC	3556	GAGAAGCA CUGAUGAG GNNNNNNNNC CGAA AAGCUGGG	7700
3907	CUUCUGCUU CUCCAGCU	3557	AGCUGGAG CUGAUGAG GNNNNNNNNC CGAA AGCAGAAG	7701
3908	UUCUGCUUC UCCAGCUG	3558	CAGCUGGA CUGAUGAG GNNNNNNNNC CGAA AAGCAGAA	7702
3910	CUGCUUCUC CAGCUGUG	3559	CACAGCUG CUGAUGAG GNNNNNNNNC CGAA AGAAGCAG	7703
3926	GGCCACAUC AGGCCCGU	3560	ACGGGCCU CUGAUGAG GNNNNNNNNC CGAA AUGUGGCC	7704
3949	CGAUGAAUC UGAGCUGG	3561	CCAGCUCA CUGAUGAG GNNNNNNNNC CGAA AUUCAUCG	7705
3967	AAAGGAGUC CUGCUGUU	3562	AACAGCAG CUGAUGAG GNNNNNNNNC CGAA ACUCCUUU	7706
3975	CCUGCUGUU CUCCACCC	3563	GGGUGGAG CUGAUGAG GNNNNNNNNC CGAA ACAGCAGG	7707
3976	CUGCUGUUC UCCACCCC	3564	GGGGUGGA CUGAUGAG GNNNNNNNNC CGAA AACAGCAG	7708
3978	GCUGUUCUC CACCCCCA	3565	UGGGGGUG CUGAUGAG GNNNNNNNNC CGAA AGAACAGC	7709
3991	CCCAGACUA CAACUCCG	3566	CGGAGUUG CUGAUGAG GNNNNNNNNC CGAA AGUCUGGG	7710
3997	CUACAACUC CGUGGUGU	3567	ACACCACG CUGAUGAG GNNNNNNNNC CGAA AGUUGUAG	7711
4006	CGUGGUGUU GUACUCCU	3568	AGGAGUAC CUGAUGAG GNNNNNNNNC CGAA ACACCACG	7712
4009	GGUGUUGUA CUCCUCCC	3569	GGGAGGAG CUGAUGAG GNNNNNNNNC CGAA ACAACACC	7713
4012	GUUGUACUC CUCCCCGC	3570	GCGGGGAG CUGAUGAG GNNNNNNNNC CGAA AGUACAAC	7714
4015	GUACUCCUC CCCGCCCG	3571	CGGGCGGG CUGAUGAG GNNNNNNNNC CGAA AGGAGUAC	7715
4027	GCCCGCCUA AAGCUUCU	3572	AGAAGCUU CUGAUGAG GNNNNNNNNC CGAA AGGCGGGC	7716
4033	CUAAAGCUU CUCACCAG	3573	CUGGUGAG CUGAUGAG GNNNNNNNNC CGAA AGCUUUAG	7717
4034	UAAAGCUUC UCACCAGC	3574	GCUGGUGA CUGAUGAG GNNNNNNNNC CGAA AAGCUUUA	7718
4036	AAGCUUCUC ACCAGCCC	3575	GGGCUGGU CUGAUGAG GNNNNNNNNC CGAA AGAAGCUU	7719
4066	CUGACAGUA UUAUACAU	3576	AUGUAUAA CUGAUGAG GNNNNNNNNC CGAA ACUGUCAG	7720
4068	GACAGUAUU AUACAUCU	3577	AGAUGUAU CUGAUGAG GNNNNNNNNC CGAA AUACUGUC	7721
4069	ACAGUAUUA UACAUCUA	3578	UAGAUGUA CUGAUGAG GNNNNNNNNC CGAA AAUACUGU	7722
4071	AGUAUUAUA CAUCUAUG	3579	CAUAGAUG CUGAUGAG GNNNNNNNNC CGAA AUAAUACU	7723
4075	UUAUACAUC UAUGAGUU	3580	AACUCAUA CUGAUGAG GNNNNNNNNC CGAA AUGUAUAA	7724
4077	AUACAUCUA UGAGUUUA	3581	UAAACUCA CUGAUGAG GNNNNNNNNC CGAA AGAUGUAU	7725
4083	CUAUGAGUU UACACCUA	3582	UAGGUGUA CUGAUGAG GNNNNNNNNC CGAA ACUCAUAG	7726
4084	UAUGAGUUU ACACCUAU	3583	AUAGGUGU CUGAUGAG GNNNNNNNNC CGAA AACUCAUA	7727
4085	AUGAGUUUA CACCUAUU	3584	AAUAGGUG CUGAUGAG GNNNNNNNNC CGAA AAACUCAU	7728
4091	UUACACCUA UUCCGCUC	3585	GAGCGGAA CUGAUGAG GNNNNNNNNC CGAA AGGUGUAA	7729
4093	ACACCUAUU CCGCUCCA	3586	UGGAGCGG CUGAUGAG GNNNNNNNNC CGAA AUAGGUGU	7730
4094	CACCUAUUC CGCUCCAC	3587	GUGGAGCG CUGAUGAG GNNNNNNNNC CGAA AAUAGGUG	7731
4099	AUUCCGCUC CACAGGAG	3588	CUCCUGUG CUGAUGAG GNNNNNNNNC CGAA AGCGGAAU	7732
4117	CAGCUGCUU UUCGUGAC	3589	GUCACGAA CUGAUGAG GNNNNNNNNC CGAA AGCAGCUG	7733
4118	AGCUGCUUU UCGUGACC	3590	GGUCACGA CUGAUGAG GNNNNNNNNC CGAA AAGCAGCU	7734
4119	GCUGCUUUU CGUGACCU	3591	AGGUCACG CUGAUGAG GNNNNNNNNC CGAA AAAGCAGC	7735
4120	CUGCUUUUC GUGACCUU	3592	AAGGUCAC CUGAUGAG GNNNNNNNNC CGAA AAAAGCAG	7736
4128	CGUGACCUU UAAUCGUG	3593	CACGAUUA CUGAUGAG GNNNNNNNNC CGAA AGGUCACG	7737
4129	GUGACCUUU AAUCGUGC	3594	GCACGAUU CUGAUGAG GNNNNNNNNC CGAA AAGGUCAC	7738
4130	UGACCUUUA AUCGUGCU	3595	AGCACGAU CUGAUGAG GNNNNNNNNC CGAA AAAGGUCA	7739
4133	CCUUUAAUC GUGCUUUU	3596	AAAAGCAC CUGAUGAG GNNNNNNNNC CGAA AUUAAAGG	7740
4139	AUCGUGCUU UUUUGUUU	3597	AAACAAAA CUGAUGAG GNNNNNNNNC CGAA AGCACGAU	7741
4140	UCGUGCUUU UUUGUUUU	3598	AAAACAAA CUGAUGAG GNNNNNNNNC CGAA AAGCACGA	7742
4141	CGUGCUUUU UUGUUUUU	3599	AAAAACAA CUGAUGAG GNNNNNNNNC CGAA AAAGCACG	7743
4142	GUGCUUUUU UGUUUUUU	3600	AAAAAACA CUGAUGAG GNNNNNNNNC CGAA AAAAGCAC	7744
4143	UGCUUUUUU GUUUUUUG	3601	CAAAAAAC CUGAUGAG GNNNNNNNNC CGAA AAAAAGCA	7745
4146	UUUUUUGUU UUUUGUUU	3602	AAACAAAA CUGAUGAG GNNNNNNNNC CGAA ACAAAAAA	7746
4147	UUUUUGUUU UUUGUUUU	3603	AAAACAAA CUGAUGAG GNNNNNNNNC CGAA AACAAAAA	7747
4148	UUUUGUUUU UUGUUUUG	3604	CAAAACAA CUGAUGAG GNNNNNNNNC CGAA AAACAAAA	7748
4149	UUUGUUUUU UGUUUUGU	3605	ACAAAACA CUGAUGAG GNNNNNNNNC CGAA AAAACAAA	7749
4150	UUGUUUUUU GUUUUGUU	3606	AACAAAAC CUGAUGAG GNNNNNNNNC CGAA AAAAACAA	7750
4153	UUUUUUGUU UUGUUUGU	3607	ACAAACAA CUGAUGAG GNNNNNNNNC CGAA ACAAAAAA	7751
4154	UUUUUGUUU UGUUUGUU	3608	AACAAACA CUGAUGAG GNNNNNNNNC CGAA AACAAAAA	7752
4155	UUUUGUUUU GUUUGUUG	3609	CAACAAAC CUGAUGAG GNNNNNNNNC CGAA AAACAAAA	7753
4158	UGUUUUGUU UGUUGUUG	3610	CAACAACA CUGAUGAG GNNNNNNNNC CGAA ACAAAACA	7754
4159	GUUUUGUUU GUUGUUGC	3611	GCAACAAC CUGAUGAG GNNNNNNNNC CGAA AACAAAAC	7755
4162	UUGUUUGUU GUUGCUGU	3612	ACAGCAAC CUGAUGAG GNNNNNNNNC CGAA ACAAACAA	7756
4165	UUUGUUGUU GCUGUUUU	3613	AAAACAGC CUGAUGAG GNNNNNNNNC CGAA ACAACAAA	7757
4171	GUUGCUGUU UUGACUAA	3614	UUAGUCAA CUGAUGAG GNNNNNNNNC CGAA ACAGCAAC	7758
4172	UUGCUGUUU UGACUAAC	3615	GUUAGUCA CUGAUGAG GNNNNNNNNC CGAA AACAGCAA	7759
4173	UGCUGUUUU GACUAACA	3616	UGUUAGUC CUGAUGAG GNNNNNNNNC CGAA AAACAGCA	7760
4178	UUUUGACUA ACAAGAAU	737	AUUCUUGU CUGAUGAG GNNNNNNNNC CGAA AGUCAAAA	4893
4189	AAGAAUGUA ACCCCAGU	3617	ACUGGGGU CUGAUGAG GNNNNNNNNC CGAA ACAUUCUU	7761
4198	ACCCCAGUU AGUGACGU	3618	ACGUCACU CUGAUGAG GNNNNNNNNC CGAA ACUGGGGU	7762
4199	CCCCAGUUA GUGACGUG	3619	CACGUCAC CUGAUGAG GNNNNNNNNC CGAA AACUGGGG	7763
4216	UGAAGAAUA CUAUUGUU	3620	AACAAUAG CUGAUGAG GNNNNNNNNC CGAA AUUCUUCA	7764
4219	AGAAUACUA UUGUUAGA	3621	UCUAACAA CUGAUGAG GNNNNNNNNC CGAA AGUAUUCU	7765
4221	AAUACUAUU GUUAGAGA	3622	UCUCUAAC CUGAUGAG GNNNNNNNNC CGAA AUAGUAUU	7766
4224	ACUAUUGUU AGAGAAAU	3623	AUUUCUCU CUGAUGAG GNNNNNNNNC CGAA ACAAUAGU	7767
4225	CUAUUGUUA GAGAAAUC	3624	GAUUUCUC CUGAUGAG GNNNNNNNNC CGAA AACAAUAG	7768
4233	AGAGAAAUC CCCCCCGC	3625	GCGGGGGG CUGAUGAG GNNNNNNNNC CGAA AUUUCUCU	7769
4249	CAAAGCCUC AGGGUAAC	3626	GUUACCCU CUGAUGAG GNNNNNNNNC CGAA AGGCUUUG	7770
4255	CUCAGGGUA ACCUGGAC	3627	GUCCAGGU CUGAUGAG GNNNNNNNNC CGAA ACCCUGAG	7771
4282	AGGUGCCUC UGGCGACC	3628	GGUCGCCA CUGAUGAG GNNNNNNNNC CGAA AGGCACCU	7772
4323	CCCACCCUC CCUGCAGC	3629	GCUGCAGG CUGAUGAG GNNNNNNNNC CGAA AGGGUGGG	7773
4341	GUGGGACUA GAGGCAGU	3630	ACUGCCUC CUGAUGAG GNNNNNNNNC CGAA AGUCCCAC	7774
4350	GAGGCAGUA AGCCCAUU	3631	AAUGGGCU CUGAUGAG GNNNNNNNNC CGAA ACUGCCUC	7775
4358	AAGCCCAUU AGCUCAUG	3632	CAUGAGCU CUGAUGAG GNNNNNNNNC CGAA AUGGGCUU	7776
4359	AGCCCAUUA GCUCAUGG	3633	CCAUGAGC CUGAUGAG GNNNNNNNNC CGAA AAUGGGCU	7777
4363	CAUUAGCUC AUGGCUGC	3634	GCAGCCAU CUGAUGAG GNNNNNNNNC CGAA AGCUAAUG	7778
4387	GACCUGCUC UGUCUCUC	3635	GAGAGACA CUGAUGAG GNNNNNNNNC CGAA AGCAGGUC	7779
4391	UGCUCUGUC UCUCUUAU	3636	AUAAGAGA CUGAUGAG GNNNNNNNNC CGAA ACAGAGCA	7780
4393	CUCUGUCUC UCUUAUGG	3637	CCAUAAGA CUGAUGAG GNNNNNNNNC CGAA AGACAGAG	7781
4395	CUGUCUCUC UUAUGGAG	3638	CUCCAUAA CUGAUGAG GNNNNNNNNC CGAA AGAGACAG	7782
4397	GUCUCUCUU AUGGAGGA	3639	UCCUCCAU CUGAUGAG GNNNNNNNNC CGAA AGAGAGAC	7783
4398	UCUCUCUUA UGGAGGAA	3640	UUCCUCCA CUGAUGAG GNNNNNNNNC CGAA AAGAGAGA	7784
4445	AAAAGGCUU UGGGAUGC	3641	GCAUCCCA CUGAUGAG GNNNNNNNNC CGAA AGCCUUUU	7785
4446	AAAGGCUUU GGGAUGCG	3642	CGCAUCCC CUGAUGAG GNNNNNNNNC CGAA AAGCCUUU	7786
4456	GGAUGCGUC CGUCCUGU	3643	ACAGGACG CUGAUGAG GNNNNNNNNC CGAA ACGCAUCC	7787
4460	GCGUCCGUC CUGUGGAG	3644	CUCCACAG CUGAUGAG GNNNNNNNNC CGAA ACGGACGC	7788
4487	AGGGGGCUC CGCUAUGC	3645	GCAUAGCG CUGAUGAG GNNNNNNNNC CGAA AGCCCCCU	7789
4492	GCUCCGCUA UGCCACUU	3646	AAGUGGCA CUGAUGAG GNNNNNNNNC CGAA AGCGGAGC	7790
4500	AUGCCACUU CAGUGACU	3647	AGUCACUG CUGAUGAG GNNNNNNNNC CGAA AGUGGCAU	7791
4501	UGCCACUUC AGUGACUU	3648	AAGUCACU CUGAUGAG GNNNNNNNNC CGAA AAGUGGCA	7792
4509	CAGUGACUU CUCACUCC	3649	GGAGUGAG CUGAUGAG GNNNNNNNNC CGAA AGUCACUG	7793
4510	AGUGACUUC UCACUCCU	3650	AGGAGUGA CUGAUGAG GNNNNNNNNC CGAA AAGUCACU	7794
4512	UGACUUCUC ACUCCUGG	3651	CCAGGAGU CUGAUGAG GNNNNNNNNC CGAA AGAAGUCA	7795
4516	UUCUCACUC CUGGCCUC	3652	GAGGCCAG CUGAUGAG GNNNNNNNNC CGAA AGUGAGAA	7796
4524	CCUGGCCUC CGCUGUUU	3653	AAACAGCG CUGAUGAG GNNNNNNNNC CGAA AGGCCAGG	7797
4531	UCCGCUGUU UCGGGCCC	3654	GGGCCCGA CUGAUGAG GNNNNNNNNC CGAA ACAGCGGA	7798
4532	CCGCUGUUU CGGGCCCC	3655	GGGGCCCG CUGAUGAG GNNNNNNNNC CGAA AACAGCGG	7799
4533	CGCUGUUUC GGGCCCCC	3656	GGGGGCCC CUGAUGAG GNNNNNNNNC CGAA AAACAGCG	7800
4543	GGCCCCCUU CCAAGAGG	3657	CCUCUUGG CUGAUGAG GNNNNNNNNC CGAA AGGGGGCC	7801
4544	GCCCCCUUC CAAGAGGU	3658	ACCUCUUG CUGAUGAG GNNNNNNNNC CGAA AAGGGGGC	7802
4553	CAAGAGGUA UCAGAGCA	3659	UGCUCUGA CUGAUGAG GNNNNNNNNC CGAA ACCUCUUG	7803
4555	AGAGGUAUC AGAGCAGA	3660	UCUGCUCU CUGAUGAG GNNNNNNNNC CGAA AUACCUCU	7804
4577	AGGGACGUU UCCUAGAC	3661	GUCUAGGA CUGAUGAG GNNNNNNNNC CGAA ACGUCCCU	7805
4578	GGGACGUUU CCUAGACC	3662	GGUCUAGG CUGAUGAG GNNNNNNNNC CGAA AACGUCCC	7806
4579	GGACGUUUC CUAGACCA	3663	UGGUCUAG CUGAUGAG GNNNNNNNNC CGAA AAACGUCC	7807
4582	CGUUUCCUA GACCAGGG	3664	CCCUGGUC CUGAUGAG GNNNNNNNNC CGAA AGGAAACG	7808
4598	GCACAUGUU CUCGGGAA	3665	UUCCCGAG CUGAUGAG GNNNNNNNNC CGAA ACAUGUGC	7809
4599	CACAUGUUC UCGGGAAC	3666	GUUCCCGA CUGAUGAG GNNNNNNNNC CGAA AACAUGUG	7810
4601	CAUGUUCUC GGGAACCA	3667	UGGUUCCC CUGAUGAG GNNNNNNNNC CGAA AGAACAUG	7811
4614	ACCACAGUU AAUCUUAA	3668	UUAAGAUU CUGAUGAG GNNNNNNNNC CGAA ACUGUGGU	7812
4615	CCACAGUUA AUCUUAAA	3669	UUUAAGAU CUGAUGAG GNNNNNNNNC CGAA AACUGUGG	7813
4618	CAGUUAAUC UUAAAUCU	3670	AGAUUUAA CUGAUGAG GNNNNNNNNC CGAA AUUAACUG	7814
4620	GUUAAUCUU AAAUCUUU	3671	AAAGAUUU CUGAUGAG GNNNNNNNNC CGAA AGAUUAAC	7815
4621	UUAAUCUUA AAUCUUUU	3672	AAAAGAUU CUGAUGAG GNNNNNNNNC CGAA AAGAUUAA	7816
4625	UCUUAAAUC UUUUCCCG	3673	CGGGAAAA CUGAUGAG GNNNNNNNNC CGAA AUUUAAGA	7817
4627	UUAAAUCUU UUCCCGGG	3674	CCCGGGAA CUGAUGAG GNNNNNNNNC CGAA AGAUUUAA	7818
4628	UAAAUCUUU UCCCGGGA	3675	UCCCGGGA CUGAUGAG GNNNNNNNNC CGAA AAGAUUUA	7819
4629	AAAUCUUUU CCCGGGAG	3676	CUCCCGGG CUGAUGAG GNNNNNNNNC CGAA AAAGAUUU	7820
4630	AAUCUUUUC CCGGGAGU	3677	ACUCCCGG CUGAUGAG GNNNNNNNNC CGAA AAAAGAUU	7821
4639	CCGGGAGUC UUCUGUUG	3678	CAACAGAA CUGAUGAG GNNNNNNNNC CGAA ACUCCCGG	7822
4641	GGGAGUCUU CUGUUGUC	3679	GACAACAG CUGAUGAG GNNNNNNNNC CGAA AGACUCCC	7823
4642	GGAGUCUUC UGUUGUCU	3680	AGACAACA CUGAUGAG GNNNNNNNNC CGAA AAGACUCC	7824
4646	UCUUCUGUU GUCUGUUU	3681	AAACAGAC CUGAUGAG GNNNNNNNNC CGAA ACAGAAGA	7825
4649	UCUGUUGUC UGUUUACC	3682	GGUAAACA CUGAUGAG GNNNNNNNNC CGAA ACAACAGA	7826
4653	UUGUCUGUU UACCAUCC	3683	GGAUGGUA CUGAUGAG GNNNNNNNNC CGAA ACAGACAA	7827
4654	UGUCUGUUU ACCAUCCA	3684	UGGAUGGU CUGAUGAG GNNNNNNNNC CGAA AACAGACA	7828
4655	GUCUGUUUA CCAUCCAA	3685	UUGGAUGG CUGAUGAG GNNNNNNNNC CGAA AAACAGAC	7829
4660	UUUACCAUC CAAAGCAU	3686	AUGCUUUG CUGAUGAG GNNNNNNNNC CGAA AUGGUAAA	7830
4669	CAAAGCAUA UUUAACAU	3687	AUGUUAAA CUGAUGAG GNNNNNNNNC CGAA AUGCUUUG	7831
4671	AAGCAUAUU UAACAUGU	3688	ACAUGUUA CUGAUGAG GNNNNNNNNC CGAA AUAUGCUU	7832
4672	AGCAUAUUU AACAUGUG	3689	CACAUGUU CUGAUGAG GNNNNNNNNC CGAA AAUAUGCU	7833
4673	GCAUAUUUA ACAUGUGU	3690	ACACAUGU CUGAUGAG GNNNNNNNNC CGAA AAAUAUGC	7834
4682	ACAUGUGUC AGUGGGGG	3691	CCCCCACU CUGAUGAG GNNNNNNNNC CGAA ACACAUGU	7835
4698	GUGGCGCUU GGCUUCUG	3692	CAGAAGCC CUGAUGAG GNNNNNNNNC CGAA AGCGCCAC	7836
4703	GCUUGGCUU CUGAGGCC	3693	GGCCUCAG CUGAUGAG GNNNNNNNNC CGAA AGCCAAGC	7837
4704	CUUGGCUUC UGAGGCCA	3694	UGGCCUCA CUGAUGAG GNNNNNNNNC CGAA AAGCCAAG	7838
4720	AGAGCCAUC AUCAGUUC	3695	GAACUGAU CUGAUGAG GNNNNNNNNC CGAA AUGGCUCU	7839
4723	GCCAUCAUC AGUUCCUC	3696	GAGGAACU CUGAUGAG GNNNNNNNNC CGAA AUGAUGGC	7840
4727	UCAUCAGUU CCUCUAGU	3697	ACUAGAGG CUGAUGAG GNNNNNNNNC CGAA ACUGAUGA	7841
4728	CAUCAGUUC CUCUAGUG	3698	CACUAGAG CUGAUGAG GNNNNNNNNC CGAA AACUGAUG	7842
4731	CAGUUCCUC UAGUGAGA	3699	UCUCACUA CUGAUGAG GNNNNNNNNC CGAA AGGAACUG	7843
4733	GUUCCUCUA GUGAGAUG	3700	CAUCUCAC CUGAUGAG GNNNNNNNNC CGAA AGAGGAAC	7844
4745	AGAUGCAUU GAGGUCAU	3701	AUGACCUC CUGAUGAG GNNNNNNNNC CGAA AUGCAUCU	7845
4751	AUUGAGGUC AUACCCAA	3702	UUGGGUAU CUGAUGAG GNNNNNNNNC CGAA ACCUCAAU	7846
4754	GAGGUCAUA CCCAAGCU	3703	AGCUUGGG CUGAUGAG GNNNNNNNNC CGAA AUGACCUC	7847
4763	CCCAAGCUU GCAGGCCU	3704	AGGCCUGC CUGAUGAG GNNNNNNNNC CGAA AGCUUGGG	7848
4777	CCUGACCUU CGCAUACU	3705	AGUAUGCG CUGAUGAG GNNNNNNNNC CGAA AGGUCAGG	7849
4778	CUGACCUUC GCAUACUG	3706	CAGUAUGC CUGAUGAG GNNNNNNNNC CGAA AAGGUCAG	7850
4783	CUUCGCAUA CUGCUCAC	3707	GUGAGCAG CUGAUGAG GNNNNNNNNC CGAA AUGCGAAG	7851
4789	AUACUGCUC ACGGGGAG	3708	CUCCCCGU CUGAUGAG GNNNNNNNNC CGAA AGCAGUAU	7852
4799	CGGGGAGUU AAGUGGUC	3709	GACCACUU CUGAUGAG GNNNNNNNNC CGAA ACUCCCCG	7853
4800	GGGGAGUUA AGUGGUCC	3710	GGACCACU CUGAUGAG GNNNNNNNNC CGAA AACUCCCC	7854
4807	UAAGUGGUC CAGUUUGG	3711	CCAAACUG CUGAUGAG GNNNNNNNNC CGAA ACCACUUA	7855
4812	GGUCCAGUU UGGCCUAG	3712	CUAGGCCA CUGAUGAG GNNNNNNNNC CGAA ACUGGACC	7856
4813	GUCCAGUUU GGCCUAGU	3713	ACUAGGCC CUGAUGAG GNNNNNNNNC CGAA AACUGGAC	7857
4819	UUUGGCCUA GUAAGGUU	3714	AACCUUAC CUGAUGAG GNNNNNNNNC CGAA AGGCCAAA	7858
4822	GGCCUAGUA AGGUUGCC	3715	GGCAACCU CUGAUGAG GNNNNNNNNC CGAA ACUAGGCC	7859
4827	AGUAAGGUU GCCUACUG	3716	CAGUAGGC CUGAUGAG GNNNNNNNNC CGAA ACCUUACU	7860
4832	GGUUGCCUA CUGAUGGG	3717	CCCAUCAG CUGAUGAG GNNNNNNNNC CGAA AGGCAACC	7861
4843	GAUGGGCUC AAAAGCCA	3718	UGGCUUUU CUGAUGAG GNNNNNNNNC CGAA AGCCCAUC	7862
4855	AGCCACAUU UUAAACAG	3719	CUGUUUAA CUGAUGAG GNNNNNNNNC CGAA AUGUGGCU	7863
4856	GCCACAUUU UAAACAGG	3720	CCUGUUUA CUGAUGAG GNNNNNNNNC CGAA AAUGUGGC	7864
4857	CCACAUUUU AAACAGGU	3721	ACCUGUUU CUGAUGAG GNNNNNNNNC CGAA AAAUGUGG	7865
4858	CACAUUUUA AACAGGUU	3722	AACCUGUU CUGAUGAG GNNNNNNNNC CGAA AAAAUGUG	7866
4866	AAACAGGUU UUAUCUCA	3723	UGAGAUAA CUGAUGAG GNNNNNNNNC CGAA ACCUGUUU	7867
4867	AACAGGUUU UAUCUCAA	3724	UUGAGAUA CUGAUGAG GNNNNNNNNC CGAA AACCUGUU	7868
4868	ACAGGUUUU AUCUCAAG	3725	CUUGAGAU CUGAUGAG GNNNNNNNNC CGAA AAACCUGU	7869
4869	CAGGUUUUA UCUCAAGU	3726	ACUUGAGA CUGAUGAG GNNNNNNNNC CGAA AAAACCUG	7870
4871	GGUUUUAUC UCAAGUAU	3727	AUACUUGA CUGAUGAG GNNNNNNNNC CGAA AUAAAACC	7871
4873	UUUUAUCUC AAGUAUUA	3728	UAAUACUU CUGAUGAG GNNNNNNNNC CGAA AGAUAAAA	7872
4878	UCUCAAGUA UUAAUAUA	3729	UAUAUUAA CUGAUGAG GNNNNNNNNC CGAA ACUUGAGA	7873
4880	UCAAGUAUU AAUAUAUA	3730	UAUAUAUU CUGAUGAG GNNNNNNNNC CGAA AUACUUGA	7874
4881	CAAGUAUUA AUAUAUAG	3731	CUAUAUAU CUGAUGAG GNNNNNNNNC CGAA AAUACUUG	7875
4884	GUAUUAAUA UAUAGACA	3732	UGUCUAUA CUGAUGAG GNNNNNNNNC CGAA AUUAAUAC	7876
4886	AUUAAUAUA UAGACAAG	3733	CUUGUCUA CUGAUGAG GNNNNNNNNC CGAA AUAUUAAU	7877
4888	UAAUAUAUA GACAAGAC	3734	GUCUUGUC CUGAUGAG GNNNNNNNNC CGAA AUAUAUUA	7878
4900	AAGACACUU AUGCAUUA	3735	UAAUGCAU CUGAUGAG GNNNNNNNNC CGAA AGUGUCUU	7879
4901	AGACACUUA UGCAUUAU	3736	AUAAUGCA CUGAUGAG GNNNNNNNNC CGAA AAGUGUCU	7880
4907	UUAUGCAUU AUCCUGUU	3737	AACAGGAU CUGAUGAG GNNNNNNNNC CGAA AUGCAUAA	7881
4908	UAUGCAUUA UCCUGUUU	3738	AAACAGGA CUGAUGAG GNNNNNNNNC CGAA AAUGCAUA	7882
4910	UGCAUUAUC CUGUUUUA	3739	UAAAACAG CUGAUGAG GNNNNNNNNC CGAA AUAAUGCA	7883
4915	UAUCCUGUU UUAUAUAU	3740	AUAUAUAA CUGAUGAG GNNNNNNNNC CGAA ACAGGAUA	7884
4916	AUCCUGUUU UAUAUAUC	3741	GAUAUAUA CUGAUGAG GNNNNNNNNC CGAA AACAGGAU	7885
4917	UCCUGUUUU AUAUAUCC	3742	GGAUAUAU CUGAUGAG GNNNNNNNNC CGAA AAACAGGA	7886
4918	CCUGUUUUA UAUAUCCA	3743	UGGAUAUA CUGAUGAG GNNNNNNNNC CGAA AAAACAGG	7887
4920	UGUUUUAUA UAUCCAAU	3744	AUUGGAUA CUGAUGAG GNNNNNNNNC CGAA AUAAAACA	7888
4922	UUUUAUAUA UCCAAUGA	3745	UCAUUGGA CUGAUGAG GNNNNNNNNC CGAA AUAUAAAA	7889
4924	UUAUAUAUC CAAUGAAU	3746	AUUCAUUG CUGAUGAG GNNNNNNNNC CGAA AUAUAUAA	7890
4933	CAAUGAAUA UAACUGGG	3747	CCCAGUUA CUGAUGAG GNNNNNNNNC CGAA AUUCAUUG	7891
4935	AUGAAUAUA ACUGGGGC	3748	GCCCCAGU CUGAUGAG GNNNNNNNNC CGAA AUAUUCAU	7892
4948	GGGCGAGUU AAGAGUCA	3749	UGACUCUU CUGAUGAG GNNNNNNNNC CGAA ACUCGCCC	7893
4949	GGCGAGUUA AGAGUCAU	3750	AUGACUCU CUGAUGAG GNNNNNNNNC CGAA AACUCGCC	7894
4955	UUAAGAGUC AUGGUCUA	3751	UAGACCAU CUGAUGAG GNNNNNNNNC CGAA ACUCUUAA	7895
4961	GUCAUGGUC UAGAAAAG	3752	CUUUUCUA CUGAUGAG GNNNNNNNNC CGAA ACCAUGAC	7896
4963	CAUGGUCUA GAAAAGGG	3753	CCCUUUUC CUGAUGAG GNNNNNNNNC CGAA AGACCAUG	7897
4974	AAAGGGGUU UCUCUGUA	3754	UACAGAGA CUGAUGAG GNNNNNNNNC CGAA ACCCCUUU	7898
4975	AAGGGGUUU CUCUGUAC	3755	GUACAGAG CUGAUGAG GNNNNNNNNC CGAA AACCCCUU	7899
4976	AGGGGUUUC UCUGUACC	3756	GGUACAGA CUGAUGAG GNNNNNNNNC CGAA AAACCCCU	7900
4978	GGGUUUCUC UGUACCCA	3757	UGGGUACA CUGAUGAG GNNNNNNNNC CGAA AGAAACCC	7901
4982	UUCUCUGUA CCCAAAUC	3758	GAUUUGGG CUGAUGAG GNNNNNNNNC CGAA ACAGAGAA	7902
4990	ACCCAAAUC GGGCUGGU	3759	ACCAGCCC CUGAUGAG GNNNNNNNNC CGAA AUUUGGGU	7903
4999	GGGCUGGUU GGACCAAG	3760	CUUGGUCC CUGAUGAG GNNNNNNNNC CGAA ACCAGCCC	7904
5029	AGAGUGGUU GUCCCAGC	3761	GCUGGGAC CUGAUGAG GNNNNNNNNC CGAA ACCACUCU	7905
5032	GUGGUUGUC CCAGCUAU	3762	AUAGCUGG CUGAUGAG GNNNNNNNNC CGAA ACAACCAC	7906
5039	UCCCAGCUA UAGUUACU	3763	AGUAACUA CUGAUGAG GNNNNNNNNC CGAA AGCUGGGA	7907
5041	CCAGCUAUA GUUACUAA	3764	UUAGUAAC CUGAUGAG GNNNNNNNNC CGAA AUAGCUGG	7908
5044	GCUAUAGUU ACUAAACU	3765	AGUUUAGU CUGAUGAG GNNNNNNNNC CGAA ACUAUAGC	7909
5045	CUAUAGUUA CUAAACUA	3766	UAGUUUAG CUGAUGAG GNNNNNNNNC CGAA AACUAUAG	7910
5048	UAGUUACUA AACUACUC	3767	GAGUAGUU CUGAUGAG GNNNNNNNNC CGAA AGUAACUA	7911
5053	ACUAAACUA CUCACCCA	3768	UGGGUGAG CUGAUGAG GNNNNNNNNC CGAA AGUUUAGU	7912
5056	AAACUACUC ACCCAAAG	3769	CUUUGGGU CUGAUGAG GNNNNNNNNC CGAA AGUAGUUU	7913
5066	CCCAAAGUU GGGACCUC	3770	GAGGUCCC CUGAUGAG GNNNNNNNNC CGAA ACUUUGGG	7914
5074	UGGGACCUC ACUGGCUU	3771	AAGCCAGU CUGAUGAG GNNNNNNNNC CGAA AGGUCCCA	7915
5082	CACUGGCUU CUCUUUAC	3772	GUAAAGAG CUGAUGAG GNNNNNNNNC CGAA AGCCAGUG	7916
5083	ACUGGCUUC UCUUUACU	3773	AGUAAAGA CUGAUGAG GNNNNNNNNC CGAA AAGCCAGU	7917
5085	UGGCUUCUC UUUACUUC	3774	GAAGUAAA CUGAUGAG GNNNNNNNNC CGAA AGAAGCCA	7918
5087	GCUUCUCUU UACUUCAU	3775	AUGAAGUA CUGAUGAG GNNNNNNNNC CGAA AGAGAAGC	7919
5088	CUUCUCUUU ACUUCAUC	3776	GAUGAAGU CUGAUGAG GNNNNNNNNC CGAA AAGAGAAG	7920
5089	UUCUCUUUA CUUCAUCA	3777	UGAUGAAG CUGAUGAG GNNNNNNNNC CGAA AAAGAGAA	7921
5092	UCUUUACUU CAUCAUGG	3778	CCAUGAUG CUGAUGAG GNNNNNNNNC CGAA AGUAAAGA	7922
5093	CUUUACUUC AUCAUGGA	3779	UCCAUGAU CUGAUGAG GNNNNNNNNC CGAA AAGUAAAG	7923
5096	UACUUCAUC AUGGAUUU	3780	AAAUCCAU CUGAUGAG GNNNNNNNNC CGAA AUGAAGUA	7924
5103	UCAUGGAUU UCACCAUC	3781	GAUGGUGA CUGAUGAG GNNNNNNNNC CGAA AUCCAUGA	7925
5104	CAUGGAUUU CACCAUCC	3782	GGAUGGUG CUGAUGAG GNNNNNNNNC CGAA AAUCCAUG	7926
5105	AUGGAUUUC ACCAUCCC	3783	GGGAUGGU CUGAUGAG GNNNNNNNNC CGAA AAAUCCAU	7927
5111	UUCACCAUC CCAAGGCA	3784	UGCCUUGG CUGAUGAG GNNNNNNNNC CGAA AUGGUGAA	7928
5122	AAGGCAGUC UGAGAGGA	3785	UCCUCUCA CUGAUGAG GNNNNNNNNC CGAA ACUGCCUU	7929
5134	GAGGAGCUA AAGAGUAU	3786	AUACUCUU CUGAUGAG GNNNNNNNNC CGAA AGCUCCUC	7930
5141	UAAAGAGUA UCAGCCCA	3787	UGGGCUGA CUGAUGAG GNNNNNNNNC CGAA ACUCUUUA	7931
5143	AAGAGUAUC AGCCCAUA	3788	UAUGGGCU CUGAUGAG GNNNNNNNNC CGAA AUACUCUU	7932
5151	CAGCCCAUA UUUAUUAA	3789	UUAAUAAA CUGAUGAG GNNNNNNNNC CGAA AUGGGCUG	7933
5153	GCCCAUAUU UAUUAAGC	3790	GCUUAAUA CUGAUGAG GNNNNNNNNC CGAA AUAUGGGC	7934
5154	CCCAUAUUU AUUAAGCA	3791	UGCUUAAU CUGAUGAG GNNNNNNNNC CGAA AAUAUGGG	7935
5155	CCAUAUUUA UUAAGCAC	3792	GUGCUUAA CUGAUGAG GNNNNNNNNC CGAA AAAUAUGG	7936
5157	AUAUUUAUU AAGCACUU	3793	AAGUGCUU CUGAUGAG GNNNNNNNNC CGAA AUAAAUAU	7937
5158	UAUUUAUUA AGCACUUU	3794	AAAGUGCU CUGAUGAG GNNNNNNNNC CGAA AAUAAAUA	7938
5165	UAAGCACUU UAUGCUCC	3795	GGAGCAUA CUGAUGAG GNNNNNNNNC CGAA AGUGCUUA	7939
5166	AAGCACUUU AUGCUCCU	3796	AGGAGCAU CUGAUGAG GNNNNNNNNC CGAA AAGUGCUU	7940
5167	AGCACUUUA UGCUCCUU	3797	AAGGAGCA CUGAUGAG GNNNNNNNNC CGAA AAAGUGCU	7941
5172	UUUAUGCUC CUUGGCAC	3798	GUGCCAAG CUGAUGAG GNNNNNNNNC CGAA AGCAUAAA	7942
5175	AUGCUCCUU GGCACAGC	3799	GCUGUGCC CUGAUGAG GNNNNNNNNC CGAA AGGAGCAU	7943
5195	UGAUGUGUA AUUUAUGC	3800	GCAUAAAU CUGAUGAG GNNNNNNNNC CGAA ACACAUCA	7944
5198	UGUGUAAUU UAUGCAAG	3801	CUUGCAUA CUGAUGAG GNNNNNNNNC CGAA AUUACACA	7945
5199	GUGUAAUUU AUGCAAGC	3802	GCUUGCAU CUGAUGAG GNNNNNNNNC CGAA AAUUACAC	7946
5200	UGUAAUUUA UGCAAGCU	3803	AGCUUGCA CUGAUGAG GNNNNNNNNC CGAA AAAUUACA	7947
5209	UGCAAGCUC CCUCUCCA	3804	UGGAGAGG CUGAUGAG GNNNNNNNNC CGAA AGCUUGCA	7948
5213	AGCUCCCUC UCCAGCUA	3805	UAGCUGGA CUGAUGAG GNNNNNNNNC CGAA AGGGAGCU	7949
5215	CUCCCUCUC CAGCUAGG	3806	CCUAGCUG CUGAUGAG GNNNNNNNNC CGAA AGAGGGAG	7950
5221	CUCCAGCUA GGACUCAG	3807	CUGAGUCC CUGAUGAG GNNNNNNNNC CGAA AGCUGGAG	7951
5227	CUAGGACUC AGGAUAUU	3808	AAUAUCCU CUGAUGAG GNNNNNNNNC CGAA AGUCCUAG	7952
5233	CUCAGGAUA UUAGUCAA	3809	UUGACUAA CUGAUGAG GNNNNNNNNC CGAA AUCCUGAG	7953
5235	CAGGAUAUU AGUCAAUG	3810	CAUUGACU CUGAUGAG GNNNNNNNNC CGAA AUAUCCUG	7954
5236	AGGAUAUUA GUCAAUGA	3811	UCAUUGAC CUGAUGAG GNNNNNNNNC CGAA AAUAUCCU	7955
5239	AUAUUAGUC AAUGAGCC	3812	GGCUCAUU CUGAUGAG GNNNNNNNNC CGAA ACUAAUAU	5095
5250	UGAGCCAUC AAAAGGAA	3813	UUCCUUUU CUGAUGAG GNNNNNNNNC CGAA AUGGCUCA	7956
5273	AAAAACCUA UCUUAUUU	3814	AAAUAAGA CUGAUGAG GNNNNNNNNC CGAA AGGUUUUU	7957
5275	AAACCUAUC UUAUUUUC	3815	GAAAAUAA CUGAUGAG GNNNNNNNNC CGAA AUAGGUUU	7958
5277	ACCUAUCUU AUUUUCAU	3816	AUGAAAAU CUGAUGAG GNNNNNNNNC CGAA AGAUAGGU	7959
5278	CCUAUCUUA UUUUCAUC	3817	GAUGAAAA CUGAUGAG GNNNNNNNNC CGAA AAGAUAGG	7960
5280	UAUCUUAUU UUCAUCUG	3818	CAGAUGAA CUGAUGAG GNNNNNNNNC CGAA AUAAGAUA	7961
5281	AUCUUAUUU UCAUCUGU	3819	ACAGAUGA CUGAUGAG GNNNNNNNNC CGAA AAUAAGAU	7962
5282	UCUUAUUUU CAUCUGUU	3820	AACAGAUG CUGAUGAG GNNNNNNNNC CGAA AAAUAAGA	7963
5283	CUUAUUUUC AUCUGUUU	3821	AAACAGAU CUGAUGAG GNNNNNNNNC CGAA AAAAUAAG	7964
5286	AUUUUCAUC UGUUUCAU	3822	AUGAAACA CUGAUGAG GNNNNNNNNC CGAA AUGAAAAU	7965
5290	UCAUCUGUU UCAUACCU	3823	AGGUAUGA CUGAUGAG GNNNNNNNNC CGAA ACAGAUGA	7966
5291	CAUCUGUUU CAUACCUU	3824	AAGGUAUG CUGAUGAG GNNNNNNNNC CGAA AACAGAUG	7967
5292	AUCUGUUUC AUACCUUG	3825	CAAGGUAU CUGAUGAG GNNNNNNNNC CGAA AAACAGAU	7968
5295	UGUUUCAUA CCUUGUCU	3826	AGACAAGG CUGAUGAG GNNNNNNNNC CGAA AUGAAACA	7969
5299	UCAUACCUU GUCUGGGG	3827	CCCCAGAC CUGAUGAG GNNNNNNNNC CGAA AGGUAUGA	7970
5302	UACCUUGUC UGGGGUCU	3828	AGACCCCA CUGAUGAG GNNNNNNNNC CGAA ACAAGGUA	7971
5309	UCUGGGGUC UAAUGACG	3829	CGUCAUUA CUGAUGAG GNNNNNNNNC CGAA ACCCCAGA	7972
5311	UGGGGUCUA AUGACGAU	3830	AUCGUCAU CUGAUGAG GNNNNNNNNC CGAA AGACCCCA	7973
5331	AACAGGGUA GACAUGGG	3831	CCCAUGUC CUGAUGAG GNNNNNNNNC CGAA ACCCUGUU	7974
5350	GACAGGGUA GAAAAGGG	3832	CCCUUUUC CUGAUGAG GNNNNNNNNC CGAA ACCCUGUC	7975
5367	UGCCCGCUC UUUGGGGU	3833	ACCCCAAA CUGAUGAG GNNNNNNNNC CGAA AGCGGGCA	7976
5369	CCCGCUCUU UGGGGUCU	3834	AGACCCCA CUGAUGAG GNNNNNNNNC CGAA AGAGCGGG	7977
5370	CCGCUCUUU GGGGUCUA	3835	UAGACCCC CUGAUGAG GNNNNNNNNC CGAA AAGAGCGG	7978
5376	UUUGGGGUC UAGAGAUG	3836	CAUCUCUA CUGAUGAG GNNNNNNNNC CGAA ACCCCAAA	7979
5378	UGGGGUCUA GAGAUGAG	3837	CUCAUCUC CUGAUGAG GNNNNNNNNC CGAA AGACCCCA	7980
5395	CCCUGGGUC UCUAAAAU	3838	AUUUUAGA CUGAUGAG GNNNNNNNNC CGAA ACCCAGGG	7981
5397	CUGGGUCUC UAAAAUGG	3839	CCAUUUUA CUGAUGAG GNNNNNNNNC CGAA AGACCCAG	7982
5399	GGGUCUCUA AAAUGGCU	3840	AGCCAUUU CUGAUGAG GNNNNNNNNC CGAA AGAGACCC	7983
5408	AAAUGGCUC UCUUAGAA	3841	UUCUAAGA CUGAUGAG GNNNNNNNNC CGAA AGCCAUUU	7984
5410	AUGGCUCUC UUAGAAGU	3842	ACUUCUAA CUGAUGAG GNNNNNNNNC CGAA AGAGCCAU	7985
5412	GGCUCUCUU AGAAGUUG	3843	CAACUUCU CUGAUGAG GNNNNNNNNC CGAA AGAGAGCC	7986
5413	GCUCUCUUA GAAGUUGU	3844	ACAACUUC CUGAUGAG GNNNNNNNNC CGAA AAGAGAGC	7987
5419	UUAGAAGUU GUAUGUGC	3845	GCACAUAC CUGAUGAG GNNNNNNNNC CGAA ACUUCUAA	7988
5422	GAAGUUGUA UGUGCAAA	3846	UUUGCACA CUGAUGAG GNNNNNNNNC CGAA ACAACUUC	7989
5432	GUGCAAAUU AUGGUCUG	3847	CAGACCAU CUGAUGAG GNNNNNNNNC CGAA AUUUGCAC	7990
5433	UGCAAAUUA UGGUCUGU	3848	ACAGACCA CUGAUGAG GNNNNNNNNC CGAA AAUUUGCA	7991
5438	AUUAUGGUC UGUGUGCU	3849	AGCACACA CUGAUGAG GNNNNNNNNC CGAA ACCAUAAU	7992
5447	UGUGUGCUU AGGUCGUG	3850	CACGACCU CUGAUGAG GNNNNNNNNC CGAA AGCACACA	7993
5448	GUGUGCUUA GGUCGUGC	3851	GCACGACC CUGAUGAG GNNNNNNNNC CGAA AAGCACAC	7994
5452	GCUUAGGUC GUGCACAC	3852	GUGUGCAC CUGAUGAG GNNNNNNNNC CGAA ACCUAAGC	7995
5475	GAGCCGGUC ACAGCUGG	3853	CCAGCUGU CUGAUGAG GNNNNNNNNC CGAA ACCGGCUC	7996
5497	CGAUGAAUA GCUGCUUU	3854	AAAGCAGC CUGAUGAG GNNNNNNNNC CGAA AUUCAUCG	7997
5504	UAGCUGCUU UGGGAGAG	3855	CUCUCCCA CUGAUGAG GNNNNNNNNC CGAA AGCAGCUA	7998
5505	AGCUGCUUU GGGAGAGC	3856	GCUCUCCC CUGAUGAG GNNNNNNNNC CGAA AAGCAGCU	7999
5524	AGCAUGCUA GCCACUUA	3857	UAAGUGGC CUGAUGAG GNNNNNNNNC CGAA AGCAUGCU	8000
5531	UAGCCACUU AAUUCUCU	3858	AGAGAAUU CUGAUGAG GNNNNNNNNC CGAA AGUGGCUA	8001
5532	AGCCACUUA AUUCUCUG	3859	CAGAGAAU CUGAUGAG GNNNNNNNNC CGAA AAGUGGCU	8002
5535	CACUUAAUU CUCUGACC	3860	GGUCAGAG CUGAUGAG GNNNNNNNNC CGAA AUUAAGUG	8003
5536	ACUUAAUUC UCUGACCG	3861	CGGUCAGA CUGAUGAG GNNNNNNNNC CGAA AAUUAAGU	8004
5538	UUAAUUCUC UGACCGGG	3862	CCCGGUCA CUGAUGAG GNNNNNNNNC CGAA AGAAUUAA	8005
5554	GCCAGCAUC AUGGGUAC	3863	GUACCCAU CUGAUGAG GNNNNNNNNC CGAA AUGCUGGC	8006
5561	UCAUGGGUA CCUGCUCC	3864	GGAGCAGG CUGAUGAG GNNNNNNNNC CGAA ACCCAUGA	8007
5568	UACCUGCUC CCCUGUGU	3865	ACACAGGG CUGAUGAG GNNNNNNNNC CGAA AGCAGGUA	8008
5577	CCCUGUGUA CCCCAUCC	3866	GGAUGGGG CUGAUGAG GNNNNNNNNC CGAA ACACAGGG	8009
5584	UACCCCAUC CUUAAGGU	3867	ACCUUAAG CUGAUGAG GNNNNNNNNC CGAA AUGGGGUA	8010
5587	CCCAUCCUU AAGGUUUU	3868	AAAACCUU CUGAUGAG GNNNNNNNNC CGAA AGGAUGGG	8011
5588	CCAUCCUUA AGGUUUUC	3869	GAAAACCU CUGAUGAG GNNNNNNNNC CGAA AAGGAUGG	8012
5593	CUUAAGGUU UUCUGUCU	3870	AGACAGAA CUGAUGAG GNNNNNNNNC CGAA ACCUUAAG	8013
5594	UUAAGGUUU UCUGUCUG	3871	CAGACAGA CUGAUGAG GNNNNNNNNC CGAA AACCUUAA	8014
5595	UAAGGUUUU CUGUCUGA	3872	UCAGACAG CUGAUGAG GNNNNNNNNC CGAA AAACCUUA	8015
5596	AAGGUUUUC UGUCUGAU	3873	AUCAGACA CUGAUGAG GNNNNNNNNC CGAA AAAACCUU	8016
5600	UUUUCUGUC UGAUGAGA	3874	UCUCAUCA CUGAUGAG GNNNNNNNNC CGAA ACAGAAAA	8017
5627	AGUGCAAUC CCCACUGA	3875	UCAGUGGG CUGAUGAG GNNNNNNNNC CGAA AUUGCACU	8018
5660	CUGUGGCUC UUGGUGCA	3876	UGCACCAA CUGAUGAG GNNNNNNNNC CGAA AGCCACAG	8019
5662	GUGGCUCUU GGUGCACU	3877	AGUGCACC CUGAUGAG GNNNNNNNNC CGAA AGAGCCAC	8020
5671	GGUGCACUC ACCAGCCA	3878	UGGCUGGU CUGAUGAG GNNNNNNNNC CGAA AGUGCACC	8021
5685	CCAGGACUA GACAAGUA	3879	UACUUGUC CUGAUGAG GNNNNNNNNC CGAA AGUCCUGG	8022
5693	AGACAAGUA GGAAAGGG	3880	CCCUUUCC CUGAUGAG GNNNNNNNNC CGAA ACUUGUCU	8023
5704	AAAGGGCUU CUAGCCAC	3881	GUGGCUAG CUGAUGAG GNNNNNNNNC CGAA AGCCCUUU	8024
5705	AAGGGCUUC UAGCCACA	3882	UGUGGCUA CUGAUGAG GNNNNNNNNC CGAA AAGCCCUU	8025
5707	GGGCUUCUA GCCACACU	3883	AGUGUGGC CUGAUGAG GNNNNNNNNC CGAA AGAAGCCC	8026
5731	AAGAAAAUC AGGUAGGG	3884	CCCUACCU CUGAUGAG GNNNNNNNNC CGAA AUUUUCUU	8027
5736	AAUCAGGUA GGGCUGGC	3885	GCCAGCCC CUGAUGAG GNNNNNNNNC CGAA ACCUGAUU	8028
5754	AAAGACAUC UUUGUCCA	3886	UGGACAAA CUGAUGAG GNNNNNNNNC CGAA AUGUCUUU	8029
5756	AGACAUCUU UGUCCAUU	3887	AAUGGACA CUGAUGAG GNNNNNNNNC CGAA AGAUGUCU	8030
5757	GACAUCUUU GUCCAUUC	3888	GAAUGGAC CUGAUGAG GNNNNNNNNC CGAA AAGAUGUC	8031
5760	AUCUUUGUC CAUUCGCA	3889	UGCGAAUG CUGAUGAG GNNNNNNNNC CGAA ACAAAGAU	8032
5764	UUGUCCAUU CGCAAAAG	3890	CUUUUGCG CUGAUGAG GNNNNNNNNC CGAA AUGGACAA	8033
5765	UGUCCAUUC GCAAAAGC	3891	GCUUUUGC CUGAUGAG GNNNNNNNNC CGAA AAUGGACA	8034
5775	CAAAAGCUC UUGUCGGC	3892	GCCGACAA CUGAUGAG GNNNNNNNNC CGAA AGCUUUUG	8035
5777	AAAGCUCUU GUCGGCUG	3893	CAGCCGAC CUGAUGAG GNNNNNNNNC CGAA AGAGCUUU	8036
5780	GCUCUUGUC GGCUGCAG	3894	CUGCAGCC CUGAUGAG GNNNNNNNNC CGAA ACAAGAGC	8037
5794	CAGUGUGUA AGUCAGGC	3895	GCCUGACU CUGAUGAG GNNNNNNNNC CGAA ACACACUG	8038
5798	GUGUAAGUC AGGCGAUG	3896	CAUCGCCU CUGAUGAG GNNNNNNNNC CGAA ACUUACAC	8039
5818	CAGAGGCUA CCAGAGAA	3897	UUCUCUGG CUGAUGAG GNNNNNNNNC CGAA AGCCUCUG	8040
5852	CCUGAGGUU UCUCAUCC	3898	GGAUGAGA CUGAUGAG GNNNNNNNNC CGAA ACCUCAGG	8041
5853	CUGAGGUUU CUCAUCCA	3899	UGGAUGAG CUGAUGAG GNNNNNNNNC CGAA AACCUCAG	8042
5854	UGAGGUUUC UCAUCCAG	3900	CUGGAUGA CUGAUGAG GNNNNNNNNC CGAA AAACCUCA	8043
5856	AGGUUUCUC AUCCAGAU	3901	AUCUGGAU CUGAUGAG GNNNNNNNNC CGAA AGAAACCU	8044
5859	UUUCUCAUC CAGAUAUC	3902	GAUAUCUG CUGAUGAG GNNNNNNNNC CGAA AUGAGAAA	8045
5865	AUCCAGAUA UCCAGCAA	3903	UUGCUGGA CUGAUGAG GNNNNNNNNC CGAA AUCUGGAU	8046
5867	CCAGAUAUC CAGCAAUU	3904	AAUUGCUG CUGAUGAG GNNNNNNNNC CGAA AUAUCUGG	8047
5875	CCAGCAAUU GGGGGGUG	3905	CACCCCCC CUGAUGAG GNNNNNNNNC CGAA AUUGCUGG	8048
5896	AAGACCAUA GAUGGUCC	3906	GGACCAUC CUGAUGAG GNNNNNNNNC CGAA AUGGUCUU	8049
5903	UAGAUGGUC CUGUAUUA	3907	UAAUACAG CUGAUGAG GNNNNNNNNC CGAA ACCAUCUA	8050
5908	GGUCCUGUA UUAUUCCG	3908	CGGAAUAA CUGAUGAG GNNNNNNNNC CGAA ACAGGACC	8051
5910	UCCUGUAUU AUUCCGAU	3909	AUCGGAAU CUGAUGAG GNNNNNNNNC CGAA AUACAGGA	8052
5911	CCUGUAUUA UUCCGAUU	3910	AAUCGGAA CUGAUGAG GNNNNNNNNC CGAA AAUACAGG	8053
5913	UGUAUUAUU CCGAUUUU	3911	AAAAUCGG CUGAUGAG GNNNNNNNNC CGAA AUAAUACA	8054
5914	GUAUUAUUC CGAUUUUA	3912	UAAAAUCG CUGAUGAG GNNNNNNNNC CGAA AAUAAUAC	8055
5919	AUUCCGAUU UUAAUAAU	3913	AUUAUUAA CUGAUGAG GNNNNNNNNC CGAA AUCGGAAU	8056
5920	UUCCGAUUU UAAUAAUC	3914	GAUUAUUA CUGAUGAG GNNNNNNNNC CGAA AAUCGGAA	8057
5921	UCCGAUUUU AAUAAUCU	3915	AGAUUAUU CUGAUGAG GNNNNNNNNC CGAA AAAUCGGA	8058
5922	CCGAUUUUA AUAAUCUA	3916	UAGAUUAU CUGAUGAG GNNNNNNNNC CGAA AAAAUCGG	8059
5925	AUUUUAAUA AUCUAAUU	3917	AAUUAGAU CUGAUGAG GNNNNNNNNC CGAA AUUAAAAU	8060
5928	UUAAUAAUC UAAUUCGU	3918	ACGAAUUA CUGAUGAG GNNNNNNNNC CGAA AUUAUUAA	8061
5930	AAUAAUCUA AUUCGUGA	3919	UCACGAAU CUGAUGAG GNNNNNNNNC CGAA AGAUUAUU	8062
5933	AAUCUAAUU CGUGAUCA	3920	UGAUCACG CUGAUGAG GNNNNNNNNC CGAA AUUAGAUU	8063
5934	AUCUAAUUC GUGAUCAU	3921	AUGAUCAC CUGAUGAG GNNNNNNNNC CGAA AAUUAGAU	8064
5940	UUCGUGAUC AUUAAGAG	3922	CUCUUAAU CUGAUGAG GNNNNNNNNC CGAA AUCACGAA	8065
5943	GUGAUCAUU AAGAGACU	3923	AGUCUCUU CUGAUGAG GNNNNNNNNC CGAA AUGAUCAC	8066
5944	UGAUCAUUA AGAGACUU	3924	AAGUCUCU CUGAUGAG GNNNNNNNNC CGAA AAUGAUCA	8067
5952	AAGAGACUU UAGUAAAU	3925	AUUUACUA CUGAUGAG GNNNNNNNNC CGAA AGUCUCUU	8068
5953	AGAGACUUU AGUAAAUG	3926	CAUUUACU CUGAUGAG GNNNNNNNNC CGAA AAGUCUCU	8069
5954	GAGACUUUA GUAAAUGU	3927	ACAUUUAC CUGAUGAG GNNNNNNNNC CGAA AAAGUCUC	8070
5957	ACUUUAGUA AAUGUCCC	3928	GGGACAUU CUGAUGAG GNNNNNNNNC CGAA ACUAAAGU	8071
5963	GUAAAUGUC CCUUUUCC	3929	GGAAAAGG CUGAUGAG GNNNNNNNNC CGAA ACAUUUAC	8072
5967	AUGUCCCUU UUCCCACA	3930	UGUGGGAA CUGAUGAG GNNNNNNNNC CGAA AGGGACAU	8073
5968	UGUCCCUUU UCCCACAA	3931	UUGUGGGA CUGAUGAG GNNNNNNNNC CGAA AAGGGACA	8074
5969	GUCCCUUUU CCCACAAA	3932	UUUGUGGG CUGAUGAG GNNNNNNNNC CGAA AAAGGGAC	8075
5970	UCCCUUUUC CCACAAAA	3933	UUUUGUGG CUGAUGAG GNNNNNNNNC CGAA AAAAGGGA	8076
5981	ACAAAAGUA AAGAAAAG	3934	CUUUUCUU CUGAUGAG GNNNNNNNNC CGAA ACUUUUGU	8077
5992	GAAAAGCUA UCGGGAUU	3935	AAUCCCGA CUGAUGAG GNNNNNNNNC CGAA AGCUUUUC	8078
5994	AAAGCUAUC GGGAUUCU	3936	AGAAUCCC CUGAUGAG GNNNNNNNNC CGAA AUAGCUUU	8079
6000	AUCGGGAUU CUCUGGUU	3937	AACCAGAG CUGAUGAG GNNNNNNNNC CGAA AUCCCGAU	8080
6001	UCGGGAUUC UCUGGUUC	3938	GAACCAGA CUGAUGAG GNNNNNNNNC CGAA AAUCCCGA	8081
6003	GGGAUUCUC UGGUUCUG	3939	CAGAACCA CUGAUGAG GNNNNNNNNC CGAA AGAAUCCC	8082
6008	UCUCUGGUU CUGCUUAA	3940	UUAAGCAG CUGAUGAG GNNNNNNNNC CGAA ACCAGAGA	8083
6009	CUCUGGUUC UGCUUAAA	3941	UUUAAGCA CUGAUGAG GNNNNNNNNC CGAA AACCAGAG	8084
6014	GUUCUGCUU AAAGACUU	3942	AAGUCUUU CUGAUGAG GNNNNNNNNC CGAA AGCAGAAC	8085
6015	UUCUGCUUA AAGACUUA	3943	UAAGUCUU CUGAUGAG GNNNNNNNNC CGAA AAGCAGAA	8086
6022	UAAAGACUU AGCUUUGG	3944	CCAAAGCU CUGAUGAG GNNNNNNNNC CGAA AGUCUUUA	8087
6023	AAAGACUUA GCUUUGGA	3945	UCCAAAGC CUGAUGAG GNNNNNNNNC CGAA AAGUCUUU	8088
6027	ACUUAGCUU UGGAGCCU	3946	AGGCUCCA CUGAUGAG GNNNNNNNNC CGAA AGCUAAGU	8089
6028	CUUAGCUUU GGAGCCUA	3947	UAGGCUCC CUGAUGAG GNNNNNNNNC CGAA AAGCUAAG	8090
6036	UGGAGCCUA UGAAAGUU	3948	AACUUUCA CUGAUGAG GNNNNNNNNC CGAA AGGCUCCA	8091
6044	AUGAAAGUU GAUCAGCC	3949	GGCUGAUC CUGAUGAG GNNNNNNNNC CGAA ACUUUCAU	8092
Where “X” represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be ≧2 base-pairs.
Underlined region can be any X sequence or linker, as described herein.

TABLE IX
Mouse flt1 VEGF Receptor-Hairpin Ribozyme and Substrate Sequence
		Seq ID		Seq ID
Pos	Substrate	No	HP Ribozyme	No
33	AUGGUCA GCU GCUGGGAC	3950	GUCCCAGC AGAA GACCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8093
36	GUCAGCU GCU GGGACACC	3951	GGUGUCCC AGAA GCUGAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8094
50	CACCGCG GUC UUGCCUUA	3952	UAAGGCAA AGAA GCGGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8095
67	ACGCGCU GCU CGGGUGUC	3953	GACACCCG AGAA GCGCGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8096
79	GGUGUCU GCU UCUCACAG	3954	CUGUGAGA AGAA GACACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8097
166	CAGGCCA GAC UCUCUUUC	3955	GAAAGAGA AGAA GGCCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8098
197	GGAGGCA GCC CACUCAUG	3956	CAUGAGUG AGAA GCCUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8099
214	GGUCUCU GCC CACGACCG	3957	CGGUCGUG AGAA GAGACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8100
266	CCCAUCG GCC UGUGGGAG	3958	CUCCCACA AGAA GAUGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8101
487	GAAGACA GCU CAUCAUCC	3959	GGAUGAUG AGAA GUCUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8102
501	AUCCCCU GCC GGGUGACG	3960	CGUCACCC AGAA GGGGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8103
566	UACCCCU GAU GGGCAAAG	3961	CUUUGCCC AGAA GGGGUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8104
640	UAGGACU GCU GAACUGCG	3962	CGCAGUUC AGAA GUCCUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8105
691	ACUAUCU GAC CCAUCGGC	3963	GCCGAUGG AGAA GAUAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8106
703	AUCGGCA GAC CAAUACAA	3964	UUGUAUUG AGAA GCCGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8107
736	UACGCCC GCC GAGCCCAG	3965	CUGGGCUC AGAA GGCGUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8108
754	UGAGACU GCU CCACGGGC	3966	GCCCGUGG AGAA GUCUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8109
766	ACGGGCA GAC UCUUGUCC	3967	GGACAAGA AGAA GCCCGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8110
871	GGCAGCG GAU UGACCGGA	3968	UCCGGUCA AGAA GCUGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8111
960	UACACCU GUC GCGUGAAG	3969	CUUCACGC AGAA GGUGUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8112
988	CGUUCCA GUC UUUCAACA	3970	UGUUGAAA AGAA GGAACG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8113
1051	GGAAGCA GCC GGUGCAGG	3971	CCUGCACC AGAA GCUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8114
1081	GAAGACG GUC CUAUCGGC	3972	GCCGAUAG AGAA GUCUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8115
1090	CCUAUCG GCU GUCCAUGA	3973	UCAUGGAC AGAA GAUAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8116
1093	AUCGGCU GUC CAUGAAAG	3974	CUUUCAUG AGAA GCCGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8117
1169	GAAGUCU GCU CGCUAUUU	3975	AAAUAGCG AGAA GACUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8118
1315	AACCUCA GAU CUACGAAA	3976	UUUCGUAG AGAA GAGGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8119
1363	UCUAUCC GCU GGGCAGCA	3977	UGCUGCCC AGAA GAUAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8120
1604	GGUGGCU GAC UCUCAGAC	3978	GUCUGAGA AGAA GCCACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8121
1612	ACUCUCA GAC CCCUGGAA	3979	UUCCAGGG AGAA GAGAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8122
1629	AUCUACA GCU GCCGGGCC	3980	GGCCCGGC AGAA GUAGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8123
1632	UACAGCU GCC GGGCCUUC	3981	GAAGGCCC AGAA GCUGUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8124
1688	UGUCACA GAU GUGCCGAA	3982	UUCGGCAC AGAA GUGACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8125
1730	GAUGCCA GCC GAAGGAGA	3983	UCUCCUUC AGAA GGCAUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8126
1753	UGAAACU GUC CUGUGUGG	3984	CCACACAG AGAA GUUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8127
2017	CACACCU GCU UCAAAACC	3985	GGUUUUGA AGAA GGUGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8128
2101	CGCCUCA GAU CACUUGGU	3986	ACCAAGUG AGAA GAGGCG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8129
2176	GCACGCU GUU UAUUGAAA	1441	UUUCAAUA AGAA GCGUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5597
2258	AAGCGCA GCC UACCUCAC	3987	GUGAGGUA AGAA GCGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8130
2305	UGGAGCU GAU CACGCUCA	3988	UGAGCGUG AGAA GCUCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8131
2383	UGAAGCG GUC UUCUUCCG	3989	CGGAAGAA AGAA GCUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8132
2405	AAAGACA GAC UACCUGUC	3990	GACAGGUA AGAA GUCUUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8133
2432	GGACCCA GAU GAAGUUCC	1445	GGAACUUC AGAA GGGUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5601
2464	GUGAACG GCU GCCCUAUG	3991	CAUAGGGC AGAA GUUCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8134
2467	AACGGCU GCC CUAUGAUG	3992	CAUCAUAG AGAA GCCGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8135
2592	CCCACCU GCC GGACUGUG	3993	CACAGUCC AGAA GGUGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8136
2596	CCUGCCG GAC UGUGGCUG	3994	CAGCCACA AGAA GGCAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8137
2653	AAGCUCU GAU GACCGAAC	3995	GUUCGGUC AGAA GAGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8138
2743	GGCCUCU GAU GGUGAUCG	3996	CGAUCACC AGAA GAGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8139
2779	GAAACCU GUC CAACUACC	3997	GGUAGUUG AGAA GGUUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8140
2814	UUAUUCU GUC UCAACAAG	3998	CUUGUUGA AGAA GAAUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8141
2831	GGACGCA GCC UUGCAUAU	3999	AUAUGCAA AGAA GCGUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8142
2895	AAGCCCC GCC UAGACAGU	4000	ACUGUCUA AGAA GGGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8143
2913	GUCAGCA GCU CAAGUGUC	4001	GACACUUG AGAA GCUGAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8144
2928	GUCACCA GCU CCAGCUUC	4002	GAAGCUGG AGAA GGUGAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8145
2934	AGCUCCA GCU UCCCUGAA	4003	UUCAGGGA AGAA GGAGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8146
3001	CCAAGCA GCC CCUCACCA	4004	UGGUGAGG AGAA GCUUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8147
3022	AAGACCU GAU UUCCUACA	4005	UGUAGGAA AGAA GGUCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8148
3033	UCCUACA GUU UCCAAGUG	4006	CACUUGGA AGAA GUAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8149
3064	AGUUUCU GUC CUCCAGAA	4007	UUCUGGAG AGAA GAAACU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8150
3179	GAACCCU GAU UAUGUGAG	4008	CUCACAUA AGAA GGGUUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	5613
3357	UUCUGCA GCC GCCUGAAG	4009	CUUCAGGC AGAA GCAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8151
3360	UGCAGCC GCC UGAAGGAA	4010	UUCCUUCA AGAA GCUGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8152
3379	GCAUGCG GAU GAGAACCC	4011	GGGUUCUC AGAA GCAUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8153
3463	GGCCCCG GUU UGCUGAAC	4012	GUUCAGCA AGAA GGGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8154
3496	GUGACCU GCU UCAAGCCA	4013	UGGCUUGA AGAA GGUCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8155
3553	CCAUACU GAC UAGAAACA	4014	UGUUUCUA AGAA GUAUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8156
3615	AAGGACG GCU UUGCAGAU	4015	AUCUGCAA AGAA GUCCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8157
3623	CUUUGCA GAU CCACAUUU	4016	AAAUGUGG AGAA GCAAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8158
3650	AAGCUCU GAU GAUGUGAG	4017	CUCACAUC AGAA GAGCUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8159
3754	ACUAUCA GCU GGACACUA	4018	UAGUGUCC AGAA GAUAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8160
3772	GCACUCU GCU GGGCUCCC	4019	GGGAGCCC AGAA GAGUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8161
3796	UGAAGCG GUU CACCUGGA	4020	UCCAGGUG AGAA GCUUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8162
3881	ACUUUCC GAU CUGCCGAG	4021	CUCGGCAG AGAA GAAAGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8163
3886	CCGAUCU GCC GAGGCCCA	4022	UGGGCCUC AGAA GAUCGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8164
3897	AGGCCCA GCU UCUGCUUC	4023	GAAGCAGA AGAA GGGCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8165
3903	AGCUUCU GCU UCUCCAGC	4024	GCUGGAGA AGAA GAAGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8166
3912	UUCUCCA GCU GUGGCCAC	4025	GUGGCCAC AGAA GGAGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8167
3969	GAGUCCU GCU GUUCUCCA	4026	UGGAGAAC AGAA GGACUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8168
3972	UCCUGCU GUU CUCCACCC	4027	GGGUGGAG AGAA GCAGGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8169
3986	ACCCCCA GAC UACAACUC	4028	GAGUUGUA AGAA GGGGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8170
4018	CCUCCCC GCC CGCCUAAA	4029	UUUAGGCG AGAA GGGAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8171
4022	CCCGCCC GCC UAAAGCUU	4030	AAGCUUUA AGAA GGCGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8172
4040	CUCACCA GCC CCGACAAC	4031	GUUGUCGG AGAA GGUGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8173
4053	ACAACCA GCC CCUGACAG	4032	CUGUCAGG AGAA GGUUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8174
4095	CUAUUCC GCU CCACAGGA	4033	UCCUGUGG AGAA GAAUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8175
4110	GGAGCCA GCU GCUUUUCG	4034	CGAAAAGC AGAA GGCUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8176
4113	GCCAGCU GCU UUUCGUGA	4035	UCACGAAA AGAA GCUGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8177
4168	UGUUGCU GUU UUGACUAA	4036	UUAGUCAA AGAA GCAACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8178
4290	GGCGACC GCC CGCCCACC	4037	GGUGGGCG AGAA GUCGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8179
4294	ACCGCCC GCC CACCGGCC	4038	GGCCGGUG AGAA GGCGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8180
4329	CCCUGCA GCU GUGGGACU	4039	AGUCCCAC AGAA GCAGGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8181
4378	AUGCACU GAC CUGCUCUG	4040	CAGAGCAG AGAA GUGCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8182
4383	CUGACCU GCU CUGUCUCU	4041	AGAGACAG AGAA GGUCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8183
4388	CUGCUCU GUC UCUCUUAU	4042	AUAAGAGA AGAA GAGCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8184
4457	UGCGUCC GUC CUGUGGAG	4043	CUCCACAG AGAA GACGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8185
4525	GGCCUCC GCU GUUUCGGG	4044	CCCGAAAC AGAA GAGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8186
4528	CUCCGCU GUU UCGGGCCC	4045	GGGCCCGA AGAA GCGGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8187
4643	GUCUUCU GUU GUCUGUUU	4046	AAACAGAC AGAA GAAGAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8188
4650	GUUGUCU GUU UACCAUCC	4047	GGAUGGUA AGAA GACAAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8189
4724	AUCAUCA GUU CCUCUAGU	4048	ACUAGAGG AGAA GAUGAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8190
4771	CAGGCCU GAC CUUCGCAU	4049	AUGCGAAG AGAA GGCCUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8191
4785	GCAUACU GCU CACGGGGA	4050	UCCCCGUG AGAA GUAUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8192
4809	UGGUCCA GUU UGGCCUAG	4051	CUAGGCCA AGAA GGACCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8193
4834	GCCUACU GAU GGGCUCAA	4052	UUGAGCCC AGAA GUAGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8194
4912	UUAUCCU GUU UUAUAUAU	4053	AUAUAUAA AGAA GGAUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8195
5119	CAAGGCA GUC UGAGAGGA	4054	UCCUCUCA AGAA GCCUUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8196
5144	AGUAUCA GCC CAUAUUUA	4055	UAAAUAUG AGAA GAUACU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8197
5287	UUCAUCU GUU UCAUACCU	4056	AGGUAUGA AGAA GAUGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8198
5363	GGUGCCC GCU CUUUGGGG	4057	CCCCAAAG AGAA GGCACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8199
5462	CACACCU GCC GGAGCCGG	4058	CCGGCUCC AGAA GGUGUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8200
5478	GGUCACA GCU GGGCAGAC	4059	GUCUGCCC AGAA GUGACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8201
5486	CUGGGCA GAC GAUGAAUA	4060	UAUUCAUC AGAA GCCCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8202
5500	AAUAGCU GCU UUGGGAGA	4061	UCUCCCAA AGAA GCUAUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8203
5539	AUUCUCU GAC CGGGCCAG	4062	CUGGCCCG AGAA GAGAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8204
5564	GGUACCU GCU CCCCUGUG	4063	CACAGGGG AGAA GGUACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8205
5597	GUUUUCU GUC UGAUGAGA	4064	UCUCAUCA AGAA GAAAAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8206
5601	UCUGUCU GAU GAGACUGG	4065	CCAGUCUC AGAA GACAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8207
5639	UGAGACA GCC UGCAGCCC	4066	GGGCUGCA AGAA GUCUCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8208
5646	GCCUGCA GCC CACUGUGG	4067	CCACAGUG AGAA GCAGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8209
5781	CUUGUCG GCU GCAGUGUG	4068	CACACUGC AGAA GACAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8210
5829	AGAAACG GAU GAGAACAG	4069	CUGUUCUC AGAA GUUUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8211
5842	AACAGCA GCC UGAGGUUU	4070	AAACCUCA AGAA GCUGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8212
5915	UUAUUCC GAU UUUAAUAA	4071	UUAUUAAA AGAA GAAUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8213
6010	UGGUUCU GCU UAAAGACU	4072	AGUCUUUA AGAA GAACCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA	8214

TABLE X
Homologous Hammerhead Ribozyme Target Sites Between
Human flt-1 and KDR RNA
nt.	flt-1	Seq	nt.	KDR	Seq
Position	Target Sequence	ID No	Position	Target Sequence	ID No
3388	CCGGGAU A UUUAUAA	4073	3151	CCGGGAUAUUUAUAA	4073
2174	AAUGUAU A CACAGGG	4074	3069	AgUGUAUcCACAGGG	4116
2990	UGCAAAU A UGGAAAU	4075	2756	UGCAAAUuUGGAAAc	4117
2693	CUCCCUU A UGAUGCC	4076	2459	CUgCCUUAUGAUGCC	4118
2981	GUUGAAU A CUGCAAA	4077	2747	GUgGAAUuCUGCAAA	4119
1359	UAUGGUU A AAAGAUG	4078	2097	UgUGGUUuAAAGAUa	4120
3390	GGGAUAU U UAUAAGA	4079	3153	GGGAUAUUUAUAAag	4121
3391	GGAUAUU U AUAAGAA	4080	3154	GGAUAUUUAUAAagA	4122
2925	ACGUGGU U AACCUGC	4081	2691	AuGUGGUcAACCUuC	4123
7140	UAUUUCU A GUCAUGA	4082	2340	UAcUUCUuGUCAUcA	4124
1785	CAAUAAU A GAAGGAA	4083	1515	CucUAAUuGAAGGAA	4125
2731	GAGACUU A AACUGGG	4084	768	uuGACUUcAACUGGG	4126
3974	GAUGACU A CCAGGGC	4085	1466	GAgGACUuCCAGGGa	4127
6590	UUAAUGU A GAAAGAA	4086	2603	aaAAUGUuGAAAGAA	4128
6705	GCCAUUU A UGACAAA	4087	3227	aCaAUUUuUGACAgA	4129
974	GUCAAAU U ACUUAGA	4088	147	uUCAAAUUACUUgcA	4130
1872	AUAAAGU U GGGACUG	4089	1602	AcAAAGUcGGGAgaG	4131
2333	ACUUGGU U UAAAAAC	4090	1088	AaaUGGUaUAAAAAu	4132
2775	AAGUGGU U CAAGCAU	4091	1745	AcaUGGUaCAAGCuU	4133
3533	UUCUCCU U AGGUGGG	4092	3296	UUuUCCUUAGGUGcu	4134
3534	UCUCCUU A GGUGGGU	4093	3297	UUUCCUUAGGUGcuU	4135
3625	GUACUCU A CUCCUGA	4094	4054	GagCUCUcCUCCUGu	4136
1814	AGCACCU U GGUUGUG	4095	1059	AGuACCUUGGUUacc	4137
2744	GGCAAAU C ACUUGGA	4096	147	uuCAAAUuACUUGcA	4130
2783	CAAGCAU C AGCAUUU	4097	796	gAAGCAUCAGCAUaa	4138
3613	GAGAGCU C CUGAGUA	4098	2968	GgaAGCUCCUGAagA	4139
4052	AAGGCCU C GCUCAAG	4099	1923	ucuGCCUuGCUCAAG	4140
5305	UCUCCAU A UCAAAAC	4100	456	ggUCCAUuUCAAAuC	4141
7158	AUGUAUU U UGUAUAC	4101	631	gUcUAUUaUGUAcAu	4142
1836	CUAGAAU U UCUGGAA	4102	1007	aUgGAAUcUCUGGug	4143
2565	CUCUCUU C UGGCUCC	4103	2328	uguUCUUCUGGCUaC	4144
4250	CUGUACU C CACCCCA	4104	3388	uUaUACUaCACCagA	4145
7124	ACAUGGU U UGGUCCU	4105	3778	cagUGGUaUGGUuCU	4146
436	AUGGUCU U UGCCUGA	4106	1337	AcGGUCUaUGCCauu	4147
2234	GCACCAU A CCUCCUG	4107	1344	augCCAUuCCUCCcc	4148
2763	GGGCUUU U GGAAAAG	4108	990	uuGCUUUUGGAAguG	4149
4229	CCAGACU A CAACUCG	4109	767	auuGACUuCAACUgG	4150
5301	GUUUUCU C CAUAUCA	4110	3307	ugcUUCUCCAUAUCc	4151
6015	AGAAUGU A UGCCUCU	4111	1917	AcuAUGUcUGCCUug	4152
6095	AUUCCCU A GUGAGCC	4112	1438	AUaCCCUuGUGAaga	4153
6236	UGUUGUU C CUCUUCU	4113	76	UagUGUUuCUCUUga	4154
5962	GCUUCCU U UUAUCCA	4114	3099	auaUCCUcUUAUCgg	4155
7629	UAUAUAU U CUCUGCU	4115	3096	gAaAUAUcCUCUuaU	4156
Lowercase letters are used to represent sequence variance between flt-1 and KDR RNA

SEQUENCE LISTING
The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO
web site (http://seqdata.uspto.gov/sequence.html?DocID=06818447B1). An electronic copy of the “Sequence Listing” will also be available from the
USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Claims

1. An enzymatic nucleic acid molecule, comprising a sequence complementary to any of the substrate sequences identified as SEQ ID NO:1597, 1641, 1892, 2086, or 2119.

2. The enzymatic nucleic acid molecule of claim 1, wherein said enzymatic nucleic acid molecule is a ribozyme.

3. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule is in a hammerhead motif.

4. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule is in a hairpin, hepatitis Delta virus, group I intron, VS nucleic acid or RNase P nucleic acid motif.

5. The enzymatic nucleic acid molecule of claim 1, wherein said enzymatic nucleic acid molecule comprises between 12 and 100 bases complementary to the RNA of KDR receptor.

6. The enzymatic nucleic acid molecule of claim 5, wherein said enzymatic nucleic acid molecule comprises between 14 and 24 bases complementary to the RNA of KDR receptor.

7. A mammalian cell comprising the enzymatic nucleic acid molecule of claim 1, wherein said mammalian cell is not a living human.

8. The mammalian cell of claim 7, wherein said mammalian cell is a human cell.

9. An expression vector comprising nucleic acid sequence encoding one or more of the enzymatic nucleic acid molecules of claim 1.

10. A mammalian cell comprising an expression vector of claim 9, wherein said mammalian cell is not a living human.

11. The mammalian cell of claim 10, wherein said mammalian cell is a human cell.

12. An enzymatic nucleic acid molecule comprising any ribozyme sequence identified as SEQ ID NO:5753, 5797, 6048, 6242, or 6275.