Complication avoidance in microsurgery (neurosurgery, opthalmology, otorhinolaryngology, limb and digit reattachment) is crucial, and minimizes patient morbidity and health care costs. Current operative techniques rely on human surgeons, who have variable skill and dexterity. They also have physiological limits to their precision, tactile sensibility and stamina. Furthermore, the precise localization of brain pathology and neural structures is often difficult to achieve during surgery due to brain shifts and deformations as the operation progresses. While Intra-operative Magnetic Resonance Imaging (iMRI) has been used to monitor brain deformations, the surgeon currently has no effective way to use the iMRI data to enhance the precision and dexterity of surgery. They are compelled to rely on old techniques, and do not take advantage of these exquisite, updated images. Consequently, the quality of the surgery and outcomes is variable, and too often sub-optimal.
Surgical robots have the potential to increase the consistency and quality of neurosurgery, and when used in conjunction with the advanced diagnostic imaging capabilities of iMRI, can offer dramatic improvements. Unfortunately, there are no surgical robots that provide the surgeon with an ambidextrous and precise surgical system that uses updated iMRI patient data to achieve accurate image-guided surgery. In addition, there is no surgical robot with force sensing technology that is compatible with MRI systems.
Traditional surgery relies on the physician's surgical skills and dexterity and ability to localize structures in the body. Surgical robots have recently been developed to address the physical human issues such as fatigue and tremor in procedures. These systems were specifically developed for Minimally Invasive Surgery (MIS) or “key-hole” general surgery, orthopaedics and stereotactic neurosurgery.
The Intuitive Surgical Inc. da Vinci and Computer Motion ZEUS robots are examples of MIS robots. MIS robots are not suitable for neurosurgery since they require a portal in the body and lack the required dexterity and ability to reposition to different surgical worksites. Furthermore, neither system is MR compatible nor is there any force feedback capability. One patent on this development is U.S. Pat. No. 6,394,998 of Wallace et al issued May 28 2002.
The da Vinci system is archetypal for general surgical robots. It has an articulated endowrist at the end of its two 7 mm diameter ‘working’ arms. A more stable camera arm with two lenses (allowing stereoscopic images) is also inserted through an 8 mm portal. The end-effectors can manipulate instruments with tips as small as 2 mm. They have seven degrees of freedom (three at the wrist). The surgeon controls the robot through a console placed in the operating room, allowing control of both the external and internal surgical environments. The surgeon's interface has instrument controllers that can filter tremor and decrease the scale of motion. Foot pedals expand the surgeon's repertoire, allowing tissue coagulation and irrigation. Visual feedback is through a proprietary stereoscopic display, called Surgical Immersion™. FDA approval has been obtained for thoracoscopic, abdominal and prostate procedures. Over one hundred da Vinci systems have been sold, and have been used to perform cholecystectomies, Nissen fundoplications, adrenalectomies, nephrectomies, mitral valve repairs, coronary artery bypass grafting and prostatectomies.
Surgical robots in orthopaedics may be classified as positioning or machining aids. Robodoc, used for hip replacement surgery, is an example of the latter. Again, they lack the dexterity, MR compatibility and force sensing needed for neurosurgery. The first-generation Robodoc was developed by IBM and the University of California Davis campus. The system was initially tested on 26 dogs in 1990. A second-generation Robodoc was built by Integrated Surgical Systems, and human trials conducted. In contrast, Kienzle developed a positioning device for total knee replacement (TKR). It locates the tibia and femur, and correctly positions the drill guide for the surgeon. Guide blocks are inserted into the drill holes, allowing the surgeon to accurately prepare the patient's bones for joint implantation. A similar system, named the Acrobot, has been developed by the Imperial College group and is designed for accurate machining of bone surfaces in TKR surgery. All the systems mentioned depend on preoperatively placed fiducial markers. Patents on this development are U.S. Pat. Nos. 5,695,500; 5,397,323 (both Taylor) U.S. Pat. Nos. 5,086,401; and 5,408,409 (both Glassman) issued in 1992 to 1997.
Robots designed for neurosurgical applications are generally restricted to positioning and holding instruments for simple procedures such as stereotactic biopsies.
In 1991, Drake reported the use of a PUMA 200 robot as a neurosurgical retractor in the resection of six thalamic astrocytomas. It is the same machine that was first used by Kwoh in 1985 to perform stereotactic biopsies. The robot has revolute joints and has six DOF. Individual joints are moved by DC servomotors, and their position and velocity tracked by optical encoders. The robot arm could be programmed to move into position, or manually manipulated in a passive mode. Its repeatability was measured at 0.05 mm, and error of accuracy at 2 mm. Its pneumatic gripper was used to clasp a brain retractor only. The cases were all performed with a BRW stereotactic frame in place, secured to the same rigid structure as the PUMA arm. This allows for stable transformation of stereotactic to robotic coordinates. Target coordinates were transferred to a computer work station with 3D CT images, enabling the brain retractor to be accurately placed in relation to the lesion. Progress in developing this system was limited by the inability to rapidly render updated 3D brain images in the operating room. The recent convergence of advanced computing, software and iMR imaging now allows us to initiate sophisticated neurorobotics.
A six DOF robot has also been used by Benabid from 1987 to position brain cannulae. It is attached to a stereotactic frame, and can use spatially encoded data from Xray, CT, MR imaging and angiography to plot its path. These images are also fused with digitized brain atlases to assist in surgical planning. Hundreds of stereotactic cases have been performed, including endoscopy (1-3). Similarly, URS (Universal Robotic Systems) has developed a six DOF hexapod robot called Evolution 1 for brain and spinal surgery. This system is based on a parallel actuator configuration, which provides it with high positional accuracy and large payload capacity. The positional accuracy is essential for stereotactic procedures and the high payload capacity may make Evolution 1 particularly well suited for drilling applications such as pedicle screw placements in the spine.
A simulation tool for neurosurgery, ROBO-SIM, has recently been developed. Patient imaging data is entered and the surgical target and corridor can be selected and planned. Virtual constraints are determined, creating no-go zones. The system can be connected to a robotic arm, NEUROBOT, which holds and positions an endoscope for the surgeon. NEUROBOT has four degrees of freedom if pivoted around the burr-hole. At this time, there are no published reports of it being used on patients. It is attached to a stereotactic frame, and can use spatially encoded data from Xray, CT, MR imaging and angiography to plot its path. Again, the systems have only one robotic arm and cannot emulate a human surgeon.
A dextrous robot called the Robot-Assisted Microsurgery system (RAMS), was developed by NASA's Jet Propulsion Laboratory. The mechanical subsystem is a six-DOF robot slave arm driven by tendons. This allows a large work envelope. It is designed to have 10 microns positioning accuracy. The master input device also has six tendon-driven joints. Simulated force feedback has been used, and it has potential to be used tele-robotically. RAMS is capable of being used to enhance various types of microsurgery, including opthalmology. Although RAMS has the required dexterity, it is still a single arm system lacking the ability to reposition itself over a large worksite. It is also not MR compatible and has no direct force feedback sensing capability and is not image-guided. Patents on this development are U.S. Pat. Nos. 5,784,542; 5,710,870; 6,385,509 and 6,233,504 all of Das and Ohm et al issued in 1998, 2001 and 2002.
The only MR compatible ‘robot’ is a simple experimental system developed by Chinzei and at the Brigham and Women's Hospital in Boston, USA. The robot consists of a passive instrument holder attached to Cartesian translational stages. The limited capabilities of the device caused it to fall into disuse.
The progress of clinical neurological sciences has depended on accurate cerebral localization and imaging technology. Over the past century, advances in cerebral imaging including contrast angiography, pneumoencephalography, and in more recent decades, ultrasound imaging, CT, MRI and frameless stereotactic navigation technology have revolutionized cerebral localization. Neurosurgery's dependence on imaging technology is epitomized by the recent flurry of iMR imaging systems developed to provide MR images during a neurosurgical procedure. Since 1996, multiple MR systems and related technologies have been developed, with over 3000 neurosurgical procedures performed worldwide. The systems possess magnet field strengths ranging from 0.12 to 1.5 Tesla, associated with varying degrees of intrusion into standard neurosurgical, anaesthetic and nursing procedures and protocols.
According to one aspect of the invention there is a provided an apparatus for use in surgical procedures comprising:
The device described in more detail hereinafter is a surgeon-operated robotic system for neurosurgery that is compatible with a Magnetic Resonance (MR) imaging system. The system allows a microsurgeon to manipulate tools tele-robotically from a control room adjacent to the operating theatre, or at a considerable distance (e.g. intercontinental and low earth orbit), and works with a specialized set of modified tools based on a subset of the standard neurosurgical tool set. The robot and tools provide 16 degrees-of freedom (DOF) movement and consists of two independently controlled surgical arms (each with eight DOF) and a camera system to view the work-site. Its function is integrated with a microscope which is placed behind the robot base, except when the robot is in stereotaxy mode and has moved down the bore of the MRI system.
The arrangement described provides a safe surgical robot that:
The robotic system has two basic modes of operation: microsurgery, and stereotactic surgery. Cranial stereotactic procedures will take place within the bore of the magnet. Microsurgical procedures will be performed outside the magnet and will involve other staff working co-operatively with the robotic system.
The use of robotics in microsurgery allows for precise motions that can be guided by microscope and/or MR images obtained during the surgical procedure, and represents a significant advance in this field. The robot will be used for parts of the procedure that require precise, tremor free motions or geometric accuracy, and as a link between the MR images and physical reality.
The system consists of a Neurosurgical Robot, a System Controller and a Surgical Workstation. The physician controls the neurosurgical robot, located in the Operating Room, via a Surgical Workstation located in a separate Control Room.
The workstation consists of the Human-Machine Interface (HMI), computer processors, and recording devices. The HMI includes two hand controllers that are used to control the spatial position and actuation of the surgical tools grasped by each arm. The surgical workstation is equipped with 4 display panels and one binocular display: one showing the 3D MR image of the brain and a real-time position of the surgical tool within the operating site; a computer status display showing system data of the robotic system; a real-time color view of the operative site captured by a field of view camera system; a 2D high resolution display of the operative field, and a 3D binocular display of the operative field. Both of the microscope displays are interfaced with high resolution cameras mounted on the right and left ocular channels of a standard surgical microscope. An additional display provides system data and control settings. The workstation contains recording devices to store intra-operative MRI and video imagery and system data. An electrical cable harness connects the robot to the System Controller. The controller translates the workstation and hand-controller commands into inputs for the robotic arm motor drives and sensors. The System Controller contains the servo-control electronics that independently move and position the robot arms. The System Controller also includes an interface for the optical joint encoders and thermistors. The backbone of the System Controller is an elaborate array of software modules and electrical hardware. The architecture of the System Controller is designed to enhance safety by single fault tolerant software and redundant electrical back-up.
The robot consists of two articulated arms with dexterous mechanical manipulators that grasp and move surgical tools attached to the arm end-effectors.
For precise tool positioning, each of the surgical arms has eight DOF. The arms are each independently small enough to operate within the confines of the working diameter of the IMRIS closed bore magnet and the device can be operated to select one or the other arm. Both can work simultaneously within an open magnet of either vertical or horizontal design. They provide frame-less stereotactic functionality when registered to fiducial markers on the head or spine. Such fiducial markers may comprise a component which can be mounted on the patient and define artifacts which can be viewed in the MR image. Such MR viewable objects are usually spherical and are made from an MR responsive material which thus generates a readily visible artifact on the MR image. Other types of optical and MR responsive objects can be used. These targets are localized and registered using a robot base-mounted mechanical digitizing arm. The images defined by the MR system can be registered relative to the arms of the robot allowing the surgeon to place the tools at the required location as determined by the MR analysis.
The robot is mounted on a vertically adjustable mobile base, moved into position for the surgical procedure, and mechanically secured using locking wheels. The robot can be positioned to function as an assistant or the primary surgeon. The mobile base enables the robot to be integrated into any operative environment equipped with the appropriate electronic and mechanical interfaces.
Surgical tools are manually inserted into the arm end-effectors. The location and orientation of the tool tip relative to the surgical target will have an accuracy of approximately one-millimeter when relying on frameless navigation alone. Further refinement of toll tip placement is based on the surgeon assessing the stereoscopic, magnified field of view provided by the binoculars at the workstation. The final accuracy achieved is therefore only limited by the combination of the spatial resolution of our visual system (rods and cones) with 30 micron resolution that our robot has achieved on breadboard testing. The location of the tool tip can be continuously monitored using the internal arm joint angles and the virtual display of the tool acquired from iMRI.
The robot and field camera are designed to be compatible with the MR environment. Compatibility ensures that the robot produces minimal MRI artifact and conversely, the operation of the robot is not disturbed by the strong electromagnetic fields generated by the MR system. All equipment exposed to the MR field uses compatible materials, components and design practices such as:
The robot drive mechanisms use an Ultrasonic piezo-electric actuator technology.
The arms and surgical tools are made of MR-compatible materials.
All electronics are RF and magnetically shielded.
Optical force sensors/strain gauges are attached to the tool interfaces to provide force-feedback inputs. The sensors are MR compatible, immune to electromagnetic interference and possess high sensitivity and fast measurement update rates.
The workstation controls the arms by transforming commands from the hand controllers and transmitting them to the Main Controller. The hand controllers act as virtual tools for the surgeon. The motion commands are filtered to remove hand tremor and typically scaled down so, for example, a 10 cm displacement of the controller would result in a tool tip displacement of 5 mm. As a safety measure, the arms are only activated if a hand switch is depressed. This will avoid inadvertent movement of the arms caused by an accidental bumping of the hand controller. In addition to providing commands to the robot, the workstation receives feedback from the robot, the Main Controller, the MR system and other devices.
The workstation has three display types: Video, MRI and Control. The video recordings of the surgical worksite are taken by stereo cameras mounted on the surgical microscope and displayed on a high resolution 2D display and a 3D binocular display, providing the surgeon with a sense of depth. A third video display is used to show a video image of the operating room. The MRI display shows the patient's imaging data with a virtual tool position superimposed on the image. This enables the surgeon to view and track the tool in real-time, thereby facilitating image-guided surgery. The MRI can be enhanced by the administration of intravenous contrast agents to show the lesion and its relationship to adjacent structures. Lastly, the Control display is used to monitor the control systems of the robot.
Surgical simulation software on the workstation allows the surgeon to plan the point of cranial trepanation and calculate safe trajectories for the surgical corridor. Virtual ‘no-go’ boundaries can be defined by the surgeon, preventing inadvertent injury to neural elements. The procedure can be practiced in virtual mode by the surgeon. This will be particularly useful when performing a rare procedure, as well as in helping to teach trainee neurosurgeons.
The following sections outline the systems, electromechanical, and workstation components and specifications.
The workstation consists of the crucial Human-Machine Interface (HMI), computer processors, and recording devices. The HMI includes two hand-controllers used to control the motion and position of the surgical tools grasped by each arm. The surgeon has multiple surgical displays: one showing the 3D MR image of the brain and a real-time position of the surgical tool within the operating site, and the other a real-time color view of the surgical site captured by the surgical microscope. A third display will provide system data and control settings. The workstation contains recording devices to store intra-operative video imagery and system data. An electrical cable harness connects the robot to the Main Controller. The controller translates the workstation and hand-controller commands into inputs for the robotic arm motor drives. The Main Controller contains the servo-control electronics that independently move and position the robot arms. The Main Controller also includes an interface for the optical joint encoders and thermistors. The backbone of the Main Controller is an elaborate array of software modules and electrical hardware. The architecture of the Main Controller is designed to enhance safety by single fault tolerant software and redundant electrical back-up.
The robot is configured as a yaw plane manipulator to reduce the number of joints affected by gravity. It consists of two articulated arms with dexterous mechanical manipulators that grasp and move surgical tools attached to the arm end-effectors. A vision system consisting of an MR compatible camera system and white LED lights is mounted on the base and manually adjusted.
For precise tool positioning, the surgical arms have 8-DOF per arm (including tool actuation). The arms are small enough to individually operate within the confines of the 68-cm working diameter of the 1.5 T magnet. The robot is mounted on a mobile base, moved into position for the surgical procedure, and mechanically secured using wheel brakes. The robot can be positioned to function as an assistant or the primary surgeon. The mobile base enables the robot to be integrated into any operative environment equipped with the appropriate electronic and mechanical interfaces.
Surgical tools are manually inserted in the arm end-effectors. For microsurgical procedures, standard tools such as forceps, needle drivers, suction, micro-scissors and dissectors are created to fit the end-effectors. The tool actuation mechanism is comprised of a mobile ring surrounding the tool handle, the vertical movement of which controls tool actuation. Circular movement of a gear mechanism generates tool rotation. Based on the end-effector configuration, a novel micro-scissor design was implemented. For stereotactic procedures, a linear drive mechanism was designed to provide accurate insertion and targeting of a cannula and introducer. Each tool is equipped with an identifier bar and color code to automatically configure software 3D models. The models are used to calculate the location and orientation of the tool tip relative to the surgical target to an accuracy of one-millimeter. This absolute accuracy is limited by the resolution of inputs from the spatially encoded MR data and also the registration method. The registration method involves calibrating the robot coordinate frame to the MR image of the patient using MR fiducials and mechanical digitizing points. The location of the tool tip is continuously monitored using a kinematic model combined with internal arm-joint angles and the virtual display of the tool acquired from iMRI or other imaging modalities such as 3D ultrasound. The tool position is calibrated mechanically and checked against its position determined from updated MR images. An incremental tool tip resolution of 30 microns can be obtained.
The robot and field of view camera are designed to be compatible with the MR environment. Compatibility ensures the robot produces minimal MRI artifact and conversely, the operation of the robot is not disturbed by the strong electromagnetic fields generated by the MR system. All equipment exposed to the MR field utilizes compatible materials and components including:
Piezoelectric motors are used for the robot drive mechanisms. They have the advantage of being non-magnetic, self-braking, MR-compatible, and able to meet the operating time specifications.
Material selection is critical for robot stiffness and MR compatibility. The upper and lower arm structural components are made of titanium and PEEK (Polyetheretherketone) respectively. Both materials have a very high resistivity, permitting placement inside the RF coil during transmission with minimal degradation of the coil quality factor. The intra-operative magnet and RF coil can accommodate titanium and PEEK in the imaging volume without significant loss of performance.
All electronics are RF and magnetically shielded and located as far from the high intensity fields as practical.
A three DOF optical force sensor system is used to provide haptic feedback to the surgeon. The design is based on the photo-elastic effect to measure strains in materials under stress. The end-effector is equipped with deformable flexures providing an interface for the surgical tools. Each flexure is positioned mutually perpendicular and contains its own optical strain sensor. This arrangement allows strains to be measured at the flexure surfaces. These strain measurements are used to calculate tool tip forces in the X, Y, Z directions, which are then sent back to the workstation hand controllers.
The Surgical Workstation incorporates a computer processor, two hand-controllers to manipulate the robot arms, a controller for positioning the microscope and lights, three types of display, and data recorders. The interface is designed to maximize ergonomic comfort and minimize surgeon fatigue.
In addition to providing commands to the robot, the workstation receives feedback from the robot, the Main Controller, the MR system, and other devices. The type of information received includes: Video from the stereo camera viewing the surgical work site via the microscope; preoperative and iMR image data; tool position and motion data from the robot controller; force-sensing (haptic) data from each arm; diagnostic or error messages from the robot controller; simultaneous talk/listen voice communication with operative staff; and patient physiologic data.
The workstation controls the arms by transforming commands from the hand-controllers and transmitting them to the Main Controller. The hand-controllers act as virtual tools for the surgeon and have 6-Degrees-of-Freedom (DOF) with 3-DOF positional force feedback. The system has a large workspace and high force feedback fidelity. Motion commands are filtered to remove hand tremor and typically scaled down. For example, a 10-cm displacement of the controller could result in a tool tip displacement of 5 mm. As a safety measure, the arms are only activated if a hand switch is depressed. This avoids inadvertent movement of the arms caused by an accidental bumping of the hand-controller. The user interface of the hand-controller has been designed to maximize ergonomic comfort.
The Video display presents a 3D stereoscopic view of the surgical site providing the surgeon with a sense of depth. Two precision aligned video cameras are fitted to the right and left ocular channels of a standard surgical microscope. Camera signals are presented on a proprietary high-resolution virtual stereomicroscope (binoculars) at the workstation. The same camera signal is displayed on a 2D-HDTV (High Definition Television) screen. The HDTV is positioned above the binoculars and serves as an alternative visual display for the surgeon and as a primary display for surgical staff and students. The binocular display was chosen over conventional 3D stereoscopic displays with polarization glasses to minimize the effects of ghosting and also to increase contrast and color depth of the image. The microscope is equipped with a support stand capable of motorized tilt of the microscope head. These mechanized features of the microscope allow the surgeon to remotely adjust the microscope head from the Surgical Workstation. Magnification and working distance can be controlled from the Workstation.
The MRI display shows a virtual tool position superimposed on the images. This enables the surgeon to view and track the tool in real-time, thereby facilitating image-guided surgery. The MRI is enhanced to show the lesion and its relationship to adjacent structures in both 2- and 3-dimensions.
The Control Panel display will show the following data:
The image guidance system of robot provides the surgeon a means of navigation, target localization and collision avoidance. Surgical simulation software on the workstation allows the surgeon to plan the point of cranial trepanation and calculate safe trajectories for the surgical corridor. Virtual boundaries defined by the surgeon prevent inadvertent injury to neural elements. Simulated procedures can be practiced in virtual mode by the surgeon.
Registration of the robot is performed using a pre-operative MRI scan and MR fiducial targets that remain near the surgical field throughout the operation. The registration between the robot and the fiducials is accomplished using a compact 3-D digital coordinate measurement arm (digitizer) located on the base of the robot. The surgical assistant uses the digitizer arm to measure the coordinates of touch points on registration targets located near the surgical field. The coordinates are transmitted to the workstation, which uses the data to calculate the geometric coordinate transformation.
It is a purely passive device and is exclusively controlled by an experienced surgeon at the workstation. An additional surgeon will also be scrubbed for microsurgical cases and will be able to manually intervene if ever needed. Audio communication between the robot operator and the OR team will be provided, and a video display of the worksite and MRI display duplicated in the OR. The robot's work envelope is tailored to a specific procedure, and suitably restricted. In addition to this, no-go zones are programmed into the proposed operation during the surgical planning phase. The software controlling the robot insists on continuous input from the surgeon, and a dead-man switch (safety interlock) also requires ongoing activation to prevent a lockdown. A user selectable limit is set via the software that will limit the amount of force that can be applied and can be affected by a current limit set at the servo level. If actuators fail, intrinsic braking will automatically freeze the robot. The actuators themselves are designed to function at low torque and force levels, reducing the risk of tissue injury. This has the added benefit of using small, light motors that enhance robot balance and dexterity. End-effector/tool motion will also be considerably slowed down when operating within a microsurgical corridor. It can perform dissection at a pace of 1 mm/sec or be accelerated to as much as 200 mm/sec when outside the work envelope and reaching out for tool changes. The transition to faster speeds will require two sequential but different electronic commands to prevent accidental speeding. The mobile iMRI also has inbuilt braking systems and moves at slow speeds as it approaches patients. Unplanned power interruption results in ‘default’ freezing of movements, and personnel can deliberately cut power through strategically placed emergency stop (E-Stop) buttons.
Clinical curbs also minimize patient risk. The current robot is excluded from performing skull exposure, as this would be a relatively difficult task for a robot but is efficiently accomplished by a surgeon. Similarly, burr-holes and bone-flaps are executed by surgeons.
The system provides an MR-compatible ambidextrous robotic system capable of microsurgery and stereotaxy. With additional surgical toolsets this system lends itself to other disciplines including plastic, opthalmological and ENT surgery. The system has a uni-dexterous configuration for deployment within a magnet bore allowing updated image guidance for stereotactic procedures. This configuration provides additional range of motion within the magnet bore. Complex microsurgery, where both robotic arms are employed, is performed outside the magnet under supervision of a scrubbed surgeon. This will also facilitate safety and tool changing.
The system has been created de novo for the specific purpose of performing microsurgery and stereotaxy. This includes standard techniques such as micro-dissection, thermo-coagulation, and fine suturing. Procedures such as tumor resection and aneurysm clipping are possible. The design of the robot is inclusive and versatile however, and is ideal in other microsurgical specialties such as opthalmology. The fine dexterity and low payload of the end-effectors precludes their use in gross manipulation of tissue and bone, as these tasks are more readily suited to humans. Other unique features include MRI-compatibility as tested at 3 T, and a mechanical navigation system. This makes the system the first truly image-guided surgical robot. It is also the only surgical robot with eight-DOF per arm (including tool actuation). Although this is significantly less than human DOF, it exceeds the six-DOF required to position a tool precisely in space and then orient it in the desired plane. Unnecessary DOF result in cumulative instability while insufficient DOF result in limited positioning of the manipulator. Surgeons performing microsurgery will instinctively eliminate redundant DOF by fixing their shoulder and elbow joints, but retain adequate dexterity in the hands and wrists to perform delicate microsurgery. The manipulators were designed to have the necessary dexterity to perform these same tasks.
The system provides the first authentic force feedback system in surgery. Coupled with an exceptional visual system, based on military optics, and auditory feedback from the surgical site, the system recreates the sound, sight and feel of conventional neurosurgery. The haptic sensibility component will also be useful for simulating rare procedures, and teaching neurosurgical residents.
One embodiment of the invention will be described in conjunction with the accompanying drawings in which:
Further details of the above generally described system are shown in the attached drawings 1 through 17.
An overview of the system is shown in
The work station includes a number of displays including a first display 16 for the MRI image, a second display 17 for the microscope image and a third display 18 for the system status. Further the work station includes two hand controllers schematically indicated at 19 and an input interface 20 allowing the surgeon to control the systems from the work station while reviewing the displays. The work station further includes a computer or processor 21, a data recording system 22 and a power supply 23.
The display 17 includes a stereoscopic display 17A which provides a simulated microscope for viewing the images generated by the stereo-microscope system 13. Further the display 17 includes a monitor 17B which displays a two dimensional screen image from the microscope system 13.
The robot manipulator 10 includes a field camera 24 which provides an image on a monitor 25 at the work station.
Turning to
The stereo microscope system is of a type which is commercially available and can be mounted on a suitable support adjacent the patient for viewing the necessary site. The stereo microscope includes two separate imaging systems one for each channel which are transmitted through suitable connection to the display 17 at the work station. Thus the surgeon can view through the microscope display 17A the three dimensional image in the form of a conventional microscope and can in addition see a two dimensional image displayed on the monitor 17B.
Similarly the magnetic resonance imaging system 14 is of a conventional construction and systems are available from a number of manufacturers. The systems are of course highly complicated and include their own control systems which are not part of the present invention so that the present workstation requires only the display of the image on the monitor 16 where that image is correlated to the position of the tool as described hereinafter.
The hand controllers 19 are also of a commercially available construction available from a number of different sources and comprise 6 degrees of freedom movable arms which can be carefully manipulated by the surgeon including end shafts 19A which can be rotated by the surgeon to simulate the rotation of the tool as described hereinafter. An actuator switch 19B on the tool allows the surgeon to operate the actuation of the tool on the robot as described hereinafter.
The robot manipulator shown in general in
In
As shown in
For convenience of illustration, the structure of the arms is shown schematically in
It will be noted that the axes 134, 139 and 145 are all vertical so that the weight of the supported components has no effect on the joint and there is no requirement for power input to maintain the position of the supported component to counteract its weight.
With regard to the horizontal joint 147, there is nominally a component of the weight of the tool which is applied to cause rotation around the axis 147. However the tool is located close to the axis 147 so that there is little turning moment around the axis 147 resulting in very little weight is applied onto joint 144. Thus the weight component to be rotated around the axis 147 is minimized thus minimizing the amount of force necessary to counteract the weight.
With regard to the axis 140 and the joint 138, it will be noted that the tool and the links 141 and 146 are arranged so that the center of gravity is approximately on the axis 140 thus ensuring the requirement to counteract the weight of those components since those components provide minimum moment around the axis 140.
With regard to the joint 132 and the axis 133, the weight applied to the joint 132 from the link 135 depends upon the position of the joint 137. Thus if the link 141 is aligned with the link 135 then the center of gravity of the cantilevered components from the joint 132 lie substantially on the axis 133 thus minimizing the moment around the axis 133. However it is necessary of course to operate the system that the joint 137 turn the link 141 around the axis 139 thus providing a cantilever effect to one side of the axis 133. However again this moment around the axis 133 is minimized by the selection of the system so that the arm normally operates with the center gravity of the portion of the arm outboard of the link 135 minimized.
Thus the forces required to provide rotation around the various axes is minimized and the forces required to maintain the position when stationary against gravity is minimized.
This minimization of the forces on the system allows the use of MRI compatible motors to drive rotation of one joint component relative to the other around the respective axes.
The arrangement described above allows the use of piezoelectric motors to drive the joints. Such piezoelectric motors are commercially available and utilize the reciprocation effect generated by a piezoelectric crystal to rotate by a ratchet effect a drive disc which is connected by gear coupling to the components of the joint to effect the necessary relative rotation.
An open view of a typical joint is shown in
The joint shown in
A suitable construction of the motors and links for the arms to embody the schematic arrangements shown in
Turning now to
The robot therefore can be used in the two arm arrangement for microsurgery in an unrestricted area outside of the closed bore magnet or for microsurgery within an open bore of a magnet should the arrangement of the magnet be suitable to provide the field of operation necessary for the two arms to operate. The two arms therefore can be used with separate tools to affect surgical procedures as described above. Such an arrangement in shown in
Within the bore of a closed magnet, there is insufficient room to receive both arms of the device so that the single arm can be used to effect stereotactic procedures. Such procedures include the insertion of a probe or cannula into a required location within the brain of the patient using the real time magnetic resonance images to direct the location and direction of the tool. Thus the single arm system can be used to carry out whatever procedures are possible with the single arm but procedures requiring two arms must be carried out by removing the patient from the closed bore moving the patient to a required location where sufficient field of operation is available, restoring the robot to its two arm configuration with the table top 112 removed and locating the robot at the required position relative to the patient and the operating table.
In
The registration system 15 (see
The same fiducial markers can be used in the MRI system even when the robot is not used in the MRI system for carrying out any procedures so that the image generated on the MRI system is registered relative to the fiducial markers or points located on the head of the patient.
As shown in
At the operating position on the table 32 is located the microscope 33 on the stand 34 which is moved to position the microscope to view the operating site at the operating location on the table 32.
The registration system 15 includes a stand 37 carrying a registration probe and associated control system 38 with the probe including a probe tip 39. The registration system 38 is mounted at a fixed position so that the location of the probe tip 39 in X, Y and Z coordinates can be located and determined by the registration system for communication to the controller 12.
Thus, with the patient fixed in place by the clamp 35, the position of each of the fiducial markers 36 is identified by the tip 39 thus providing to the system the co-ordinates of that fiducial marker. In addition the instantaneous position of the tip of the tool 26 is input into the same system thus registering the tool tip relative to the fiducial markers and therefore relative to the image displayed on the monitor 16.
The system is therefore operated so that the controller 12 operates to move the tool tip to a required position and at the same time indicates to the display system the actual location of the tool tip in the registered space defined by the fiducial markers and displayed on the monitor 16. The surgeon is therefore able to view the location of the tool tip on the monitor 16 relative to the previously obtained image and maintain the registration of those images.
In procedures carried out during the MR imaging process, the tool tip can be formed in manner which allows it to be visible in the image so that the surgeon obtains a real time image from the MRI system which locates the tool tip relative to the volume of interest visible on the monitor displaying the image.
The end effector is shown in
The tool support mechanism 148 allows rotation around the longitudinal axis 42 of the tool by a drive gear 42 actuated by a further motor P. Thus the tool, while held on the axis 42 can be rotated around its length to move the tip 40 of the tool around the axis.
Actuation of the tool is effected by moving the actuator 149 longitudinally of the axis 42. For this purpose the actuator 149 is mounted on a slide 43 carried in a track 44 and driven by a suitable mechanism along the track 44 so as to accurately locate the position of the actuator 149 along the length of the tool.
In the example shown in
Detection of the forces is applied on the tip 40 by an object engaged by the tip 40 is effected by top and bottom flexure detection components 52 and 53. Thus the actuator 148 is mounted on the top flexure component which is arranged to detect forces along the axis 42. The bottom flexure component is attached to the actuator 149 and is used to detect side to side and front to back forces in the X, Y plane.
Suitable flexure detection components are commercially available and different types can be used. For use in the magnet, however, the detection components must be MRI compatible.
One suitable example of a flexure detection system is that which uses a known optical detection system. Thus the flexure component includes a member which is flexed in response to the forces and the flexure of which changes the characteristics of reflected light within the member. Fiber optic cables supply a light source and receive the light component from the reflection, communicating the reflected light through the arm to a control module within the cabinet of the robot. Thus forces flexing the member in response to engagement of the tip of the tool with an object are communicated to the control module within the cabinet which converts the reflected light to an electrical signal proportional to the forces applied.
The control module in the cabinet communicates the electrical signals proportional to the forces to the controller 12 of the system. These forces are then amplified using conventional amplification systems and applied to the hand controllers so as to provide the previously described haptic effect to the surgeon at the hand controllers.
In
In
In
This patent application is a continuation of co-pending application Ser. No. 11/480,701 filed on Jul. 3, 2006, which is a continuation of application Ser. No. 10/639,692 filed on Aug. 13, 2003, now U.S. Pat. No. 7,155,316, which claims priority to U.S. Provisional Patent Application No. 60/402,724 filed on Aug. 13, 2002; each of these applications is incorporated by reference in its entirety. This patent application is also co-pending with application Ser. No. 11/562,768 filed on Nov. 22, 2006 and Ser. No. 11/735,983 filed on Apr. 16, 2007.
Number | Name | Date | Kind |
---|---|---|---|
3171549 | Orloff | Mar 1965 | A |
3241687 | Orloff | Mar 1966 | A |
3818154 | Presentey | Jun 1974 | A |
3923166 | Fletcher et al. | Dec 1975 | A |
4068156 | Johnson et al. | Jan 1978 | A |
4239431 | Davini | Dec 1980 | A |
4252360 | Gallaher | Feb 1981 | A |
4283165 | Vertut | Aug 1981 | A |
4300198 | Davini | Nov 1981 | A |
4598311 | Bellina | Jul 1986 | A |
4600357 | Coules | Jul 1986 | A |
4636137 | Lemelson | Jan 1987 | A |
4686698 | Tompkins et al. | Aug 1987 | A |
4704915 | Friesen et al. | Nov 1987 | A |
4706120 | Slaughter et al. | Nov 1987 | A |
4722056 | Roberts et al. | Jan 1988 | A |
4736826 | White et al. | Apr 1988 | A |
4758692 | Roeser et al. | Jul 1988 | A |
4766775 | Hodge | Aug 1988 | A |
4776230 | Susnjara | Oct 1988 | A |
4791934 | Brunnett | Dec 1988 | A |
4990839 | Schonlau | Feb 1991 | A |
4993912 | King et al. | Feb 1991 | A |
5004457 | Wyatt et al. | Apr 1991 | A |
5006122 | Wyatt et al. | Apr 1991 | A |
5038089 | Szakaly | Aug 1991 | A |
5047701 | Takarada et al. | Sep 1991 | A |
5053975 | Tsuchihashi et al. | Oct 1991 | A |
5078140 | Kwoh | Jan 1992 | A |
5086401 | Glassman et al. | Feb 1992 | A |
5094241 | Allen | Mar 1992 | A |
5116180 | Fung et al. | May 1992 | A |
5142931 | Menahem | Sep 1992 | A |
5177563 | Everett et al. | Jan 1993 | A |
5184601 | Putman | Feb 1993 | A |
5187796 | Wang et al. | Feb 1993 | A |
5223776 | Radke et al. | Jun 1993 | A |
5227707 | Mitomi et al. | Jul 1993 | A |
5251127 | Raab | Oct 1993 | A |
5265486 | Hartman et al. | Nov 1993 | A |
5279309 | Taylor et al. | Jan 1994 | A |
5299288 | Glassman et al. | Mar 1994 | A |
5305203 | Raab | Apr 1994 | A |
5305652 | Zimmer | Apr 1994 | A |
5332013 | Sugita et al. | Jul 1994 | A |
5343385 | Joskowicz et al. | Aug 1994 | A |
5343391 | Mushabac | Aug 1994 | A |
5347616 | Minami | Sep 1994 | A |
5351676 | Putman | Oct 1994 | A |
5368015 | Wilk | Nov 1994 | A |
5371836 | Mitomi et al. | Dec 1994 | A |
5382885 | Salcudean et al. | Jan 1995 | A |
5383454 | Bucholz | Jan 1995 | A |
5389101 | Heilbrun et al. | Feb 1995 | A |
5389865 | Jacobus et al. | Feb 1995 | A |
5397323 | Taylor et al. | Mar 1995 | A |
5402801 | Taylor | Apr 1995 | A |
5408409 | Glassman et al. | Apr 1995 | A |
5413454 | Movsesian | May 1995 | A |
5417210 | Funda et al. | May 1995 | A |
5441505 | Nakamura | Aug 1995 | A |
5445166 | Taylor | Aug 1995 | A |
5459382 | Jacobus et al. | Oct 1995 | A |
5494034 | Schlondorff et al. | Feb 1996 | A |
5515478 | Wang | May 1996 | A |
5524180 | Wang et al. | Jun 1996 | A |
5541622 | Engle et al. | Jul 1996 | A |
5542028 | Minami | Jul 1996 | A |
5553198 | Wang et al. | Sep 1996 | A |
5562012 | Nishi et al. | Oct 1996 | A |
5570992 | Lemelson | Nov 1996 | A |
5572999 | Funda et al. | Nov 1996 | A |
5624398 | Smith et al. | Apr 1997 | A |
5628315 | Vilsmeier et al. | May 1997 | A |
5629594 | Jacobus et al. | May 1997 | A |
5630431 | Taylor | May 1997 | A |
5642805 | Tefft | Jul 1997 | A |
5643268 | Vilsmeier | Jul 1997 | A |
5647554 | Ikegami et al. | Jul 1997 | A |
5657429 | Wang et al. | Aug 1997 | A |
5682886 | Delp et al. | Nov 1997 | A |
5682890 | Kormos et al. | Nov 1997 | A |
5691898 | Rosenberg et al. | Nov 1997 | A |
D387427 | Bucholz et al. | Dec 1997 | S |
5695500 | Taylor et al. | Dec 1997 | A |
5695501 | Carol et al. | Dec 1997 | A |
5702406 | Vilsmeier et al. | Dec 1997 | A |
5709219 | Chen et al. | Jan 1998 | A |
5710870 | Ohm et al. | Jan 1998 | A |
5735278 | Hoult et al. | Apr 1998 | A |
5748767 | Raab | May 1998 | A |
5749362 | Funda et al. | May 1998 | A |
5754741 | Wang et al. | May 1998 | A |
5762458 | Wang et al. | Jun 1998 | A |
5766126 | Anderson | Jun 1998 | A |
5769861 | Vilsmeier | Jun 1998 | A |
5781705 | Endo | Jul 1998 | A |
5784542 | Ohm et al. | Jul 1998 | A |
5792135 | Madhani et al. | Aug 1998 | A |
5794621 | Hogan et al. | Aug 1998 | A |
5797900 | Madhani et al. | Aug 1998 | A |
5797924 | Schulte et al. | Aug 1998 | A |
5799055 | Peshkin et al. | Aug 1998 | A |
5800423 | Jensen | Sep 1998 | A |
5807377 | Madhani et al. | Sep 1998 | A |
5815640 | Wang et al. | Sep 1998 | A |
5817084 | Jensen | Oct 1998 | A |
5820623 | Ng | Oct 1998 | A |
5823960 | Young et al. | Oct 1998 | A |
5828813 | Ohm | Oct 1998 | A |
5841950 | Wang et al. | Nov 1998 | A |
5851183 | Bucholz | Dec 1998 | A |
5855583 | Wang et al. | Jan 1999 | A |
5868675 | Henrion et al. | Feb 1999 | A |
5871018 | Delp et al. | Feb 1999 | A |
5871445 | Bucholz | Feb 1999 | A |
5876325 | Mizuno et al. | Mar 1999 | A |
5878193 | Wang et al. | Mar 1999 | A |
5887121 | Funda et al. | Mar 1999 | A |
5889507 | Engle et al. | Mar 1999 | A |
5891034 | Bucholz | Apr 1999 | A |
5907487 | Rosenberg et al. | May 1999 | A |
5907664 | Wang et al. | May 1999 | A |
5911036 | Wright et al. | Jun 1999 | A |
5943914 | Morimoto et al. | Aug 1999 | A |
5950629 | Taylor et al. | Sep 1999 | A |
5953196 | Zimmermann | Sep 1999 | A |
5970499 | Smith et al. | Oct 1999 | A |
5971976 | Wang et al. | Oct 1999 | A |
5971997 | Guthrie et al. | Oct 1999 | A |
5976156 | Taylor et al. | Nov 1999 | A |
6000297 | Morimoto et al. | Dec 1999 | A |
6001108 | Wang et al. | Dec 1999 | A |
6006127 | Van Der Brug et al. | Dec 1999 | A |
6007550 | Wang et al. | Dec 1999 | A |
6013087 | Adams et al. | Jan 2000 | A |
6016607 | Morimoto et al. | Jan 2000 | A |
6024695 | Taylor et al. | Feb 2000 | A |
6033415 | Mittelstadt et al. | Mar 2000 | A |
6035228 | Yanof et al. | Mar 2000 | A |
6052611 | Yanof et al. | Apr 2000 | A |
6063095 | Wang et al. | May 2000 | A |
6069932 | Peshkin et al. | May 2000 | A |
6083163 | Wegner et al. | Jul 2000 | A |
6096004 | Meglan et al. | Aug 2000 | A |
6102850 | Wang et al. | Aug 2000 | A |
6104158 | Jacobus et al. | Aug 2000 | A |
6106511 | Jensen | Aug 2000 | A |
6132368 | Cooper | Oct 2000 | A |
6132441 | Grace | Oct 2000 | A |
6149592 | Yanof et al. | Nov 2000 | A |
6167292 | Badano et al. | Dec 2000 | A |
6178345 | Vilsmeier et al. | Jan 2001 | B1 |
6184868 | Shahoian et al. | Feb 2001 | B1 |
6197017 | Brock et al. | Mar 2001 | B1 |
6201984 | Funda et al. | Mar 2001 | B1 |
6205411 | DiGioia et al. | Mar 2001 | B1 |
6223067 | Vilsmeier et al. | Apr 2001 | B1 |
6226566 | Funda et al. | May 2001 | B1 |
6231526 | Taylor et al. | May 2001 | B1 |
6233504 | Das et al. | May 2001 | B1 |
6234045 | Kaiser | May 2001 | B1 |
6235038 | Hunter et al. | May 2001 | B1 |
6236875 | Bucholz et al. | May 2001 | B1 |
6238384 | Peer | May 2001 | B1 |
6244809 | Wang et al. | Jun 2001 | B1 |
6246200 | Blumenkranz et al. | Jun 2001 | B1 |
6271833 | Rosenberg et al. | Aug 2001 | B1 |
RE37374 | Roston et al. | Sep 2001 | E |
6292713 | Jouppi et al. | Sep 2001 | B1 |
6298262 | Franck et al. | Oct 2001 | B1 |
6312435 | Wallace et al. | Nov 2001 | B1 |
6322567 | Mittelstadt et al. | Nov 2001 | B1 |
6323842 | Krukovsky | Nov 2001 | B1 |
6331181 | Tierney et al. | Dec 2001 | B1 |
6347240 | Foley et al. | Feb 2002 | B1 |
6348911 | Rosenberg et al. | Feb 2002 | B1 |
6348912 | Smith | Feb 2002 | B1 |
6349245 | Finlay | Feb 2002 | B1 |
6351659 | Vilsmeier | Feb 2002 | B1 |
6359614 | McVicar | Mar 2002 | B1 |
6364888 | Niemeyer et al. | Apr 2002 | B1 |
6379302 | Kessman et al. | Apr 2002 | B1 |
6385509 | Das et al. | May 2002 | B2 |
6393340 | Funda et al. | May 2002 | B2 |
6394998 | Wallace et al. | May 2002 | B1 |
6398726 | Ramans et al. | Jun 2002 | B1 |
6400979 | Stoianovici et al. | Jun 2002 | B1 |
6409735 | Andre et al. | Jun 2002 | B1 |
6424856 | Vilsmeier et al. | Jul 2002 | B1 |
6424885 | Niemeyer et al. | Jul 2002 | B1 |
6428547 | Vilsmeier et al. | Aug 2002 | B1 |
6432112 | Brock et al. | Aug 2002 | B2 |
6434416 | Mizoguchi et al. | Aug 2002 | B1 |
6436107 | Wang et al. | Aug 2002 | B1 |
6441577 | Blumenkranz et al. | Aug 2002 | B2 |
6451027 | Cooper et al. | Sep 2002 | B1 |
6459926 | Nowlin et al. | Oct 2002 | B1 |
6463361 | Wang et al. | Oct 2002 | B1 |
6470236 | Ohtsuki | Oct 2002 | B2 |
6490467 | Bucholz et al. | Dec 2002 | B1 |
6491691 | Morley et al. | Dec 2002 | B1 |
6491699 | Henderson et al. | Dec 2002 | B1 |
6491701 | Tierney et al. | Dec 2002 | B2 |
6493608 | Niemeyer | Dec 2002 | B1 |
6496099 | Wang et al. | Dec 2002 | B2 |
6516046 | Frohlich et al. | Feb 2003 | B1 |
6522906 | Salisbury et al. | Feb 2003 | B1 |
6522949 | Ikeda et al. | Feb 2003 | B1 |
6527443 | Vilsmeier et al. | Mar 2003 | B1 |
6546277 | Franck et al. | Apr 2003 | B1 |
6547782 | Taylor | Apr 2003 | B1 |
6551325 | Neubauer et al. | Apr 2003 | B2 |
6554844 | Lee et al. | Apr 2003 | B2 |
6561993 | Adapathya et al. | May 2003 | B2 |
6565554 | Niemeyer | May 2003 | B1 |
6574355 | Green | Jun 2003 | B2 |
6584174 | Schubert et al. | Jun 2003 | B2 |
6587750 | Gerbi et al. | Jul 2003 | B2 |
6590171 | Wolf et al. | Jul 2003 | B1 |
6594552 | Nowlin et al. | Jul 2003 | B1 |
6597971 | Kanno | Jul 2003 | B2 |
6609022 | Vilsmeier et al. | Aug 2003 | B2 |
6620173 | Gerbi et al. | Sep 2003 | B2 |
6639789 | Beger | Oct 2003 | B2 |
6642686 | Ruch | Nov 2003 | B1 |
6645196 | Nixon et al. | Nov 2003 | B1 |
6646541 | Wang et al. | Nov 2003 | B1 |
6659939 | Moll et al. | Dec 2003 | B2 |
6661571 | Shioda et al. | Dec 2003 | B1 |
6675069 | Uratani | Jan 2004 | B2 |
6675070 | Lapham | Jan 2004 | B2 |
6676669 | Charles et al. | Jan 2004 | B2 |
6676684 | Morley et al. | Jan 2004 | B1 |
6678583 | Nasr et al. | Jan 2004 | B2 |
6681151 | Weinzimmer et al. | Jan 2004 | B1 |
6684129 | Salisbury et al. | Jan 2004 | B2 |
6685698 | Morley et al. | Feb 2004 | B2 |
6690999 | Kimura | Feb 2004 | B2 |
6694162 | Hartlep | Feb 2004 | B2 |
6694164 | Glossop | Feb 2004 | B2 |
6695786 | Wang et al. | Feb 2004 | B2 |
6697044 | Shahoian et al. | Feb 2004 | B2 |
6699177 | Wang et al. | Mar 2004 | B1 |
6702805 | Stuart | Mar 2004 | B1 |
6708184 | Smith et al. | Mar 2004 | B2 |
6714629 | Vilsmeier | Mar 2004 | B2 |
6714839 | Salisbury et al. | Mar 2004 | B2 |
6720988 | Gere et al. | Apr 2004 | B1 |
6722053 | Henry et al. | Apr 2004 | B2 |
6723106 | Charles et al. | Apr 2004 | B1 |
6724922 | Vilsmeier | Apr 2004 | B1 |
6725078 | Bucholz et al. | Apr 2004 | B2 |
6728599 | Wright et al. | Apr 2004 | B2 |
6730021 | Vassiliades, Jr. et al. | May 2004 | B2 |
6731988 | Green | May 2004 | B1 |
6746443 | Morley et al. | Jun 2004 | B1 |
6748298 | Heiligensetzer | Jun 2004 | B2 |
6755338 | Hahnen et al. | Jun 2004 | B2 |
6757586 | Milojevic et al. | Jun 2004 | B2 |
6758843 | Jensen | Jul 2004 | B2 |
6763284 | Watanabe et al. | Jul 2004 | B2 |
6764445 | Ramans et al. | Jul 2004 | B2 |
6766204 | Niemeyer et al. | Jul 2004 | B2 |
6772002 | Schmidt et al. | Aug 2004 | B2 |
6772053 | Niemeyer | Aug 2004 | B2 |
6776526 | Zeiss | Aug 2004 | B2 |
6781569 | Gregorio et al. | Aug 2004 | B1 |
6783524 | Anderson et al. | Aug 2004 | B2 |
6785572 | Yanof et al. | Aug 2004 | B2 |
6785593 | Wang et al. | Aug 2004 | B2 |
6786896 | Madhani et al. | Sep 2004 | B1 |
6788018 | Blumenkranz | Sep 2004 | B1 |
6788999 | Green | Sep 2004 | B2 |
6793653 | Sanchez et al. | Sep 2004 | B2 |
6799065 | Niemeyer | Sep 2004 | B1 |
6799088 | Wang et al. | Sep 2004 | B2 |
6801008 | Jacobus et al. | Oct 2004 | B1 |
6804547 | Pelzer et al. | Oct 2004 | B2 |
6804581 | Wang et al. | Oct 2004 | B2 |
6810281 | Brock et al. | Oct 2004 | B2 |
6816755 | Habibi et al. | Nov 2004 | B2 |
6817972 | Snow | Nov 2004 | B2 |
6817974 | Cooper et al. | Nov 2004 | B2 |
6827712 | Tovey et al. | Dec 2004 | B2 |
6830174 | Hillstead et al. | Dec 2004 | B2 |
6836700 | Greene et al. | Dec 2004 | B2 |
6836703 | Wang et al. | Dec 2004 | B2 |
6837883 | Moll et al. | Jan 2005 | B2 |
6839612 | Sanchez et al. | Jan 2005 | B2 |
6840938 | Morley et al. | Jan 2005 | B1 |
6843793 | Brock et al. | Jan 2005 | B2 |
6845295 | Cheng et al. | Jan 2005 | B2 |
6845296 | Ban et al. | Jan 2005 | B2 |
6850817 | Green | Feb 2005 | B1 |
6852107 | Wang et al. | Feb 2005 | B2 |
6853856 | Yanof et al. | Feb 2005 | B2 |
6860878 | Brock | Mar 2005 | B2 |
6865253 | Blumhofer et al. | Mar 2005 | B2 |
6865411 | Erbel et al. | Mar 2005 | B2 |
6866671 | Tierney et al. | Mar 2005 | B2 |
6871117 | Wang et al. | Mar 2005 | B2 |
6873867 | Vilsmeier | Mar 2005 | B2 |
6879880 | Nowlin et al. | Apr 2005 | B2 |
6889073 | Lampman et al. | May 2005 | B2 |
6889116 | Jinno | May 2005 | B2 |
6892112 | Wang et al. | May 2005 | B2 |
6898484 | Lemelson et al. | May 2005 | B2 |
6899705 | Niemeyer | May 2005 | B2 |
6905460 | Wang et al. | Jun 2005 | B2 |
6905491 | Wang et al. | Jun 2005 | B1 |
6907318 | Passmore et al. | Jun 2005 | B2 |
6911916 | Wang et al. | Jun 2005 | B1 |
6925357 | Wang et al. | Aug 2005 | B2 |
6928490 | Bucholz et al. | Aug 2005 | B1 |
6933695 | Blumenkranz | Aug 2005 | B2 |
6936001 | Snow | Aug 2005 | B1 |
6948398 | Dybro | Sep 2005 | B2 |
6949106 | Brock et al. | Sep 2005 | B2 |
6951535 | Ghodoussi et al. | Oct 2005 | B2 |
6963792 | Green | Nov 2005 | B1 |
6965812 | Wang et al. | Nov 2005 | B2 |
6968224 | Kessman et al. | Nov 2005 | B2 |
6974449 | Niemeyer | Dec 2005 | B2 |
6985766 | Braun et al. | Jan 2006 | B2 |
6987504 | Rosenberg et al. | Jan 2006 | B2 |
6994703 | Wang et al. | Feb 2006 | B2 |
6996456 | Cordell et al. | Feb 2006 | B2 |
6999852 | Green | Feb 2006 | B2 |
7006895 | Green | Feb 2006 | B2 |
7018386 | Nakamura | Mar 2006 | B2 |
7023423 | Rosenberg | Apr 2006 | B2 |
7025064 | Wang et al. | Apr 2006 | B2 |
7025761 | Wang et al. | Apr 2006 | B2 |
7027892 | Wang et al. | Apr 2006 | B2 |
7035716 | Harris et al. | Apr 2006 | B2 |
7038657 | Rosenberg et al. | May 2006 | B2 |
7039500 | Milojevic et al. | May 2006 | B2 |
7043338 | Jinno | May 2006 | B2 |
7046765 | Wong et al. | May 2006 | B2 |
7048745 | Tierney et al. | May 2006 | B2 |
7063479 | Chinzei | Jun 2006 | B2 |
7074179 | Wang et al. | Jul 2006 | B2 |
7076286 | Mizoguchi et al. | Jul 2006 | B2 |
7083571 | Wang et al. | Aug 2006 | B2 |
7103144 | Wong et al. | Sep 2006 | B2 |
7103145 | Wong et al. | Sep 2006 | B2 |
7107090 | Salisbury et al. | Sep 2006 | B2 |
7107124 | Green | Sep 2006 | B2 |
7125403 | Julian et al. | Oct 2006 | B2 |
7155315 | Niemeyer et al. | Dec 2006 | B2 |
7155316 | Sutherland et al. | Dec 2006 | B2 |
7160308 | Otsuka et al. | Jan 2007 | B2 |
7169141 | Brock et al. | Jan 2007 | B2 |
7198630 | Lipow | Apr 2007 | B2 |
7204168 | Najafi et al. | Apr 2007 | B2 |
7209788 | Nicolelis et al. | Apr 2007 | B2 |
7239301 | Liberty et al. | Jul 2007 | B2 |
7239940 | Wang et al. | Jul 2007 | B2 |
7297142 | Brock | Nov 2007 | B2 |
7331967 | Lee et al. | Feb 2008 | B2 |
20010012932 | Peer | Aug 2001 | A1 |
20010020200 | Das et al. | Sep 2001 | A1 |
20010025183 | Shahidi | Sep 2001 | A1 |
20010037064 | Shahidi | Nov 2001 | A1 |
20020042620 | Julian et al. | Apr 2002 | A1 |
20020058929 | Green | May 2002 | A1 |
20020091374 | Cooper | Jul 2002 | A1 |
20020103476 | Madhani et al. | Aug 2002 | A1 |
20020120252 | Brock et al. | Aug 2002 | A1 |
20020128661 | Brock et al. | Sep 2002 | A1 |
20020128662 | Brock et al. | Sep 2002 | A1 |
20020138082 | Brock et al. | Sep 2002 | A1 |
20020165524 | Sanchez et al. | Nov 2002 | A1 |
20020186299 | Cofer | Dec 2002 | A1 |
20020188293 | Manxo | Dec 2002 | A1 |
20030018323 | Wallace et al. | Jan 2003 | A1 |
20030023191 | Tripp | Jan 2003 | A1 |
20030040758 | Wang et al. | Feb 2003 | A1 |
20030045888 | Brock et al. | Mar 2003 | A1 |
20030050527 | Fox et al. | Mar 2003 | A1 |
20030055410 | Evans et al. | Mar 2003 | A1 |
20030060808 | Wilk | Mar 2003 | A1 |
20030065311 | Wang et al. | Apr 2003 | A1 |
20030083648 | Wang et al. | May 2003 | A1 |
20030083650 | Wang et al. | May 2003 | A1 |
20030083673 | Tierney et al. | May 2003 | A1 |
20030109780 | Coste-Maniere et al. | Jun 2003 | A1 |
20030109877 | Morley et al. | Jun 2003 | A1 |
20030114962 | Niemeyer | Jun 2003 | A1 |
20030135204 | Lee et al. | Jul 2003 | A1 |
20030139733 | Wang et al. | Jul 2003 | A1 |
20030167061 | Schlegel et al. | Sep 2003 | A1 |
20030176948 | Green | Sep 2003 | A1 |
20030191455 | Sanchez et al. | Oct 2003 | A1 |
20030216715 | Moll et al. | Nov 2003 | A1 |
20040024385 | Stuart | Feb 2004 | A1 |
20040039485 | Niemeyer et al. | Feb 2004 | A1 |
20040077939 | Graumann | Apr 2004 | A1 |
20040106916 | Quaid et al. | Jun 2004 | A1 |
20040119682 | Levine et al. | Jun 2004 | A1 |
20040151218 | Branzoi et al. | Aug 2004 | A1 |
20040162564 | Charles et al. | Aug 2004 | A1 |
20040167515 | Petersen et al. | Aug 2004 | A1 |
20040176751 | Weitzner et al. | Sep 2004 | A1 |
20040242993 | Tajima | Dec 2004 | A1 |
20040243147 | Lipow | Dec 2004 | A1 |
20040243176 | Hahnen et al. | Dec 2004 | A1 |
20040267254 | Manzo et al. | Dec 2004 | A1 |
20050016822 | Mowatt et al. | Jan 2005 | A1 |
20050027397 | Niemeyer | Feb 2005 | A1 |
20050038416 | Wang et al. | Feb 2005 | A1 |
20050075536 | Otsuka et al. | Apr 2005 | A1 |
20050092122 | Markert et al. | May 2005 | A1 |
20050107680 | Kopf et al. | May 2005 | A1 |
20050119790 | Sanchez et al. | Jun 2005 | A1 |
20050128186 | Shahoian et al. | Jun 2005 | A1 |
20050154295 | Quistgaard et al. | Jul 2005 | A1 |
20050166413 | Crampton | Aug 2005 | A1 |
20050174324 | Liberty et al. | Aug 2005 | A1 |
20050195166 | Cooper et al. | Sep 2005 | A1 |
20050200324 | Guthart et al. | Sep 2005 | A1 |
20050204851 | Morley et al. | Sep 2005 | A1 |
20050216033 | Lee et al. | Sep 2005 | A1 |
20050228365 | Wang et al. | Oct 2005 | A1 |
20060030840 | Nowlin et al. | Feb 2006 | A1 |
20060036264 | Selover et al. | Feb 2006 | A1 |
20060047365 | Ghodoussi et al. | Mar 2006 | A1 |
20060087746 | Lipow | Apr 2006 | A1 |
20060100642 | Yang et al. | May 2006 | A1 |
20060122496 | George et al. | Jun 2006 | A1 |
20060142657 | Quaid et al. | Jun 2006 | A1 |
20060149418 | Anvari | Jul 2006 | A1 |
20060161136 | Anderson et al. | Jul 2006 | A1 |
20060161137 | Orban et al. | Jul 2006 | A1 |
20060161138 | Orban et al. | Jul 2006 | A1 |
Number | Date | Country |
---|---|---|
2246369 | Mar 1997 | CA |
0886786 | Mar 1997 | EP |
WO 9313916 | Jul 1993 | WO |
WO 9958055 | Nov 1999 | WO |
WO 0033723 | Jun 2000 | WO |
WO 02065933 | Aug 2002 | WO |
Number | Date | Country | |
---|---|---|---|
20080161830 A1 | Jul 2008 | US |
Number | Date | Country | |
---|---|---|---|
60402724 | Aug 2002 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 11480701 | Jul 2006 | US |
Child | 12027043 | US | |
Parent | 10639692 | Aug 2003 | US |
Child | 11480701 | US |