Claims
- 1. An oligonucleotide having the sequence of SEQ ID NO: 6, wherein at least one adenosine nucleotide is replaced with a thymidine, cytidine or guanosine nucleotide; at least one thymidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide; at least one guanosine nucleotide is replaced with an adenosine, thymidine or cytidine nucleotide or at least one cytidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide.
- 2. An RNA compound between about 8 and 80 nucleobases in length targeted to HCV genomic or messenger RNA, wherein said compound specifically hybridizes with said HCV genomic or mRNA and inhibits the expression of HCV.
- 3. The compound of claim 2 comprising between about 12 and 50 nucleobases in length.
- 4. The compound of claim 2 comprising between about 15 and 30 nucleobases in length.
- 5. The compound of claim 2, wherein said compound comprises SEQ ID NO: 6.
- 6. The compound of claim 2, wherein said compound is double stranded.
- 7. A double stranded RNA compound having SEQ ID NO: 6.
- 8. The compound of claim 7, wherein at least one adenosine nucleotide is replaced with a thymidine, cytidine or guanosine nucleotide; at least one uridine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide; at least one guanosine nucleotide is replaced with an adenosine, thymidine or cytidine nucleotide or at least one cytidine nucleotide is replaced with an adenosine, cytidine or guanosine nucleotide
INTRODUCTION
[0001] This application is a continuation-in-part of U.S. Ser. No. 09/853,409, filed May 11, 2001, which is a continuation-in-part of U.S. Ser. No. 09/690,936 filed Oct. 18, 2000, which is a continuation of U.S. Ser. No. 08/988,321, filed Dec. 10, 1997, now issued as U.S. Pat. No. 6,174,868, which is a continuation-in-part of U.S. Ser. No. 08/650,093, filed May 17, 1996, now issued as U.S. Pat. No. 6,391,542, which is a continuation-in-part of U.S. Ser. No. 08/452,841 filed May 30, 1995, now issued as U.S. Pat. No. 6,423,489, which in turn is a continuation-in-part of U.S. Ser. No. 08/397,220, filed Mar. 9, 1995, now issued as U.S. Pat. No. 6,284,458, which is the U.S. National Phase filing of PCT/JP93/01293 filed Sep. 10, 1993, which is a continuation-in-part of U.S. Ser. No. 07/945,289, filed Sep. 10, 1992, which is now abandoned.
Continuations (1)
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Number |
Date |
Country |
Parent |
08988321 |
Dec 1997 |
US |
Child |
09690936 |
Oct 2000 |
US |
Continuation in Parts (6)
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Number |
Date |
Country |
Parent |
09853409 |
May 2001 |
US |
Child |
10454293 |
Jun 2003 |
US |
Parent |
09690936 |
Oct 2000 |
US |
Child |
09853409 |
May 2001 |
US |
Parent |
08650093 |
May 1996 |
US |
Child |
08988321 |
Dec 1997 |
US |
Parent |
08452841 |
May 1995 |
US |
Child |
08650093 |
May 1996 |
US |
Parent |
08397220 |
Mar 1995 |
US |
Child |
08452841 |
May 1995 |
US |
Parent |
07945289 |
Sep 1992 |
US |
Child |
08397220 |
Mar 1995 |
US |