This disclosure generally relates to a contact lens having a thin silicon chip integrated therein and methods for assembling the silicon chip within the contact lens.
Silicon chips are generally assembled using flip chip bonding or wire bonding. Flip chip bonding is a method for interconnecting semiconductor devices to external circuitry (e.g., a circuit board or another chip or wafer), with solder bumps that have been deposited onto chip pads. The solder bumps are deposited on the chip pads on a top side of the wafer during a final wafer processing step. In order to mount the chip to external circuitry it is flipped over so that its top side faces down, and aligned so that its pads align with matching pads on an external circuit. The solder bumps are then melted to complete interconnects. In wire bonding, the chip is mounted to external circuitry in an upright position and wires are used to interconnect the chip pads to external circuitry. However, these silicon chip assembly methods are not suitable for assembling silicon chips on or within a contact lens. Furthermore, standard chips are too thick to fit onto a contact lens.
Various aspects are now described with reference to the drawings, wherein like reference numerals are used to refer to like elements throughout. In the following description, for purposes of explanation, numerous specific details are set forth in order to provide a more thorough understanding of one or more aspects. It is evident, however, that such aspects can be practiced without these specific details. In other instances, structures and devices are shown in block diagram form in order to facilitate describing one or more aspects.
In one or more aspects, the disclosed subject matter relates to methods for manufacturing a contact lens having an integrated circuit integrated therein or thereon. In an aspect, the method involves creating a plurality of lens contact pads on a lens substrate and creating a plurality of chip contact pads on an integrated circuit element or chip, such as a silicon chip. Assembly bonding material is then applied to the plurality of lens contact pads or the plurality of chip contact pads. The chip is then bonded to the lens substrate via the assembly bonding material whereby the lens contact pads are aligned with the chip contact pads.
After the chip is bonded to the lens substrate, the lens substrate is formed into a contact lens. In an aspect, prior to forming the lens substrate into a contact lens, the chip is sealed onto the lens substrate. The lens substrate is then cut into a ring shape and molded to match curvature of an eye over which the contact lens is to be worn. The molded lens substrate is then embedded into a hydrogel to form the contact lens.
In some aspects, the plurality of chip contact pads are formed as metal lines on the chip using photolithography. Similarly, the plurality of lens contact pads can be formed as metal lines on the lens substrate using photolithography. Yet in other aspects, the plurality of lens contact pads are formed as a plurality of metal squares having a length of about 100 microns or less.
The subject methods enable assembly of thin silicon chips within a contact lens without use of bumped pads and standard chips. In some embodiments, the disclosed methods involve thinning a silicon ship substrate down to a thickness of less than about 100 microns (e.g., within the range of 20-100 microns thick) and then dicing the thinned substrate into chips smaller than 1 mm on each side. It is to be appreciated that these noted ranges/sizes are merely exemplary, and any suitable thickness or size can be employed in accordance with embodiments described herein. Metal lines are patterned onto a chip and/or a lens substrate to create contact pads for the chip and/or the lens substrate. The metal lines also serve as wires to connect other chips and/or other electrical components of the contact lens (e.g. antennas, sensors, light illuminating diodes (LEDS), and etc.).
In various embodiments, in order to assemble a chip to the lens substrate, a small amount of low temperature assembly bonding material is placed onto contact pads of either the lens substrate or the chip using a syringe. The contact pads of the chip are then aligned with the contact pads of the lens substrate and the chip is bonded to the lens substrate using the solder material. For example, the lens substrate can include multiple contact pads that can be segmented into multiple assembly sites for assembling a chip thereto. Once respective contact pads of a particular assembly site on the lens substrate are covered with solder material, the contact pads of the chip are aligned with the lens substrate contact pads in the assembly site and the chip is bonded to the assembly site using a flip-chip bonder. The flip-chip bonder tool aligns the chip contact pads with the lens substrate contact pads and applies pressure along with temperature to create a mechanical and electrical connection between the chip and the lens substrate.
After the chip is bonded to the lens substrate, the chip can be sealed onto the lens substrate with a substance (e.g. parylene) to make the lens substrate biocompatible and to hold the chip in place. The lens substrate can then be formed into a contact lens. For example, in an aspect, the lens substrate is cut into a ring shape. The ring shape can include indentations on the inner and/or outer edges of the ring to facilitate molding of the ring and to reduce wrinkling. The ring is then molded to match curvature of the eye. The ring is further embedded into hydrogel to complete the contact lens assembly process.
With reference to
As generally described herein, chip 102 is silicon chip that can be employed by contact lens 100 to facilitate electrical operations of the contact lens. In particular, chip 102 can perform various computing and logic functions of contact lens 102. Further, although not shorn in the figures, it is to be appreciated that contact lenses disclosed herein can include multiple electrical components that connect to silicon chip 102. For example, contact lenses disclosed herein can include sensors, antennas, LEDs, power sources, and etc. In addition, although contact lens 100 (and additional contact lenses described herein) is depicted having a single silicon chip 102, it should be appreciated than contact lens 100 (and additional contact lenses described herein) can be provided having a plurality of chips 102 integrated therein.
In an embodiment, silicon chip 102 is a piece of almost pure silicon having a size smaller than standard silicon chips employed in standard computing devices. For example, while most computing devices employ silicon chips that are one square centimeter and have a thickness of about 1 millimeter, chip 102 can have a size of about 1 square millimeter and a thickness less than 100 microns. In an aspect, silicon chip 102 contains a plurality (up to millions) of transistors and other small electronic circuit components, packed and interconnected in layers beneath the surface of the chip. The surface of the silicon chip can further include a grid of metallic lines etched thereon which are used to make electrical connections to other components of the chip 102 and/or the contact lens 100
The lens substrate layer 214 having the silicon chip 206 and the contact lens material layer 216 can be combined in a variety of manners. In an aspect, in order to combine the lens substrate layer 214 and the contact lens material layer 216, the lens substrate can be dipped into liquid contact lens material 216. In another aspect, in order to combine the lens substrate layer 214 and the contact lens material layer 216, the lens substrate 214 can be coated/covered with lens contact material 216 on one or both sides of the lens substrate. Still in other aspects, in order to combine the lens substrate layer 214 and the contact lens material layer 216, the lens substrate 214 can be pressed into and/or bonded with one or more layers of lens contact material 216.
The lens substrate layer 214 and the lens material layer(s) 216 can include various materials. In an aspect, the lens substrate layer 214 and the lens material layer 216 comprise the same material. In another aspect, the lens substrate layer 214 and the lens material layer comprise different materials. The lens substrate layer 214 can include any suitable material that enables fixation of contact pads to the material (e.g. metal pads and/or metal lines) and fixation of a chip 206 to the contact pads.
Some exemplary material that can be employed as the lens substrate layer material 214 include but are not limited to a soft polymer material including but not limited to, a hydrogel, a silicone based hydrogel, a polyacrlyamide, or a hydrophilic polymer. For example, in an aspect, contact lens substrate layer 214 is formed from a substrate material that includes at least one of a crosslinked hydrogel comprising hydrophilic monomers (e.g. N-Vinylpyrrolidone, 1-Ethenyl-2-pyrrolidone,N,N-dimethylacrylamide, 2-hydroxyethyl methacrylate, hydroxyethyl acrylate, methacrylic acid and acrylic acid), a strengthening agent, a ultraviolent light (UV) blocker, or a tint. In another aspect, contact lens substrate layer 214 is formed from a substrate material that includes at least of a one silicone hydrogel (e.g. crosslinked hydrogels containing silicone macromers and monomers, as well as hydrophilic monomers that absorb water). In yet another aspect, contact lens substrate layer 214 is formed from a substrate material that includes one or more rigid materials including but not limited to, a silicone polymer, polymethyl methacrylate, or rigid gas permeable materials.
The lens material layer 216 can include any suitable material that provides support for the lens substrate layer 214, contain/embed the lens substrate layer 214 and/or otherwise form a structural and/or functional body of the contact lens. Some exemplary materials that can be employed as the lens material layer 216 can include but are not limited to a soft polymer material including but not limited to, a hydrogel, a silicone based hydrogel, a polyacrlyamide, or a hydrophilic polymer. For example, in an aspect, lens material layer 216 is formed from a substrate material that includes at least one of a crosslinked hydrogel comprising hydrophilic monomers (e.g. N-Vinylpyrrolidone, 1-Ethenyl-2-pyrrolidone,N,N-dimethylacrylamide, 2-hydroxyethyl methacrylate, hydroxyethyl acrylate, methacrylic acid and acrylic acid), a strengthening agent, a ultraviolent light (UV) blocker, or a tint. In another aspect, lens material layer 216 is formed from a substrate material that includes at least of a one silicone hydrogel (e.g. crosslinked hydrogels containing silicone macromers and monomers, as well as hydrophilic monomers that absorb water). In yet another aspect, lens material layer 216 is formed from a substrate material that includes one or more rigid materials including but not limited to, a silicone polymer, polymethyl methacrylate, or rigid gas permeable materials.
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In an aspect, the surface of chip 304 on which the metal lines are formed, surface 406, is a substantially flat polymer layer provided on the chip 304. According to this aspect, the metal lines 402 are patterned onto the substantially flat polymer layer using photolithography. For example, the polymer layer can include but is not limited to parylene, polyimide, and polyethylene terephthalate (PET).
Contact lens substrate 418 is also presented having lens contact pads located on a surface thereof. In an aspect, lens contact pads provide the contact points for electrically and/or physically connecting the substrate 418 with the chip 304 and/or electrically connecting other electrical components provided within a contact lens in which the lens substrate 418 is integrated, to the chip 304. In an aspect, traditional metal chip contact pads 414 can be created on a surface of lens substrate 418. For example, metal chip pads in the form of small and thin sheets of metal in the shape of squares or rectangles can be formed on a surface of the lens substrate 418 to create the lens contact pads. Such metal contact pads can have sides less than 100 microns.
However, in another aspect, metals lines 416 are patterned onto a surface of contact lens substrate 418 in a same or similar fashion as metal lines 402 patterned on chip 304. For example, metal lines 416 can be patterned onto a surface of lens substrate 418 using photolithography. As with metal lines 402, metal lines 416 can serve as lens contact pads for the lens substrate 418 and also serve as wires to connect the chip 304 to other chips and/or components of a contact lens (e.g. antennas, sensors, LEDs, and etc.) in which the chip 304 is integrated. In addition, although intersecting parallel metal lines 416 are shown forming a grid pattern on substrate 418 such a line configuration is merely depicted for exemplary purposes. In particular, lines 416 can be formed in any pattern, in includes patterns having non-intersecting lines and patterns having non-parallel lines.
In an aspect, the lens substrate and/or a surface of lens substrate 418 on which the metal lines 416 are formed is a substantially flat polymer layer. According to this aspect, the metal lines 416 are patterned onto the substantially flat polymer layer using photolithography. For example, the polymer layer can include but is not limited to parylene, polyimide, and polyethylene terephthalate (PET).
It should be appreciated that both traditional metal contact pads 414 and metal line contact pads 416 are provided on lens substrate 418 merely for exemplary purposes. Further, although only a partial area of the lens substrate 418 is presented having contact pads thereon, it should be appreciated that any portion of the substrate 418 can be provided with contact pads. For example, the entire surface of the substrate 418 can be patterned with metal lines or square metal pads. According to this example, a subset of the metal lines/metal pads can be selectively employed as the contact pads for assembly of a chip thereon. In other words, a subset of the metal lines/metal pads can be selectively employed as an assembly site for assembly of a chip thereon and the substrate can be provided with a plurality of potential assembly sites. As used herein, the term assembly site refers to an area of substrate 418 having lens contact pads that can be aligned with the contact pads of a chip.
In order to attach silicon chip 304 to contact lens substrate 418, an assembly bonding material (not shown) is applied to either the chip or the lens substrate 418. In an aspect, the assembly bonding material includes an anisotropic conductive film (ACF) or an anisotropic conductive paste (ACP). ACF and ACP are materials that establish a conducting path when pressed between two metal pads, such as a lens contact pad and a chip contact pad. According to this aspect, an ACF or ACP is applied over an entire assembly site on the substrate 418 (and/or the chip) having lens (or chip) contact pads therein so as to cover the contact pads and the area between and around the contact pads. With this aspect, assembly bonding material does not need to be applied to the contact pads individually.
After application of the ACF or ACP, the silicon chip 304 is then flipped over, following arrow 408, so that the surface 406 of the silicon chip 304 having the chip contact pads (e.g. the surface having the metal lines 402) faces a surface of the contact lens substrate 418 having the lens contact pads thereon. Dashed lines 402 presented on flipped chip 304 are indicative of the metal lines 402 now on the underside 306 of the chip. The chip 304 is then lowered onto the substrate 418 and the chip contact pads are aligned with the lens contact pads. The chip 304 is then assembled onto the lens substrate via pressing the chip 304 onto the ACF or ACP and heating the chip 304/substrate 418 assembly to cure or solidify the chip 304 connection with the substrate 418. In particular, the ACP or ACF is activated in order to secure chip 304 to substrate 418 in part by the heating. For example, activation of an ACP or ACF can include boiling a flux out of the ACP or ACF to create a conductive path between the chip contact pads and lens contact pads and to create an adhesive (e.g. an underfill) material that bonds chip 304 to substrate 418. In an aspect, heating of the of the chip 304/substrate 418 assembly is performed so that conduction results in a single direction so that the contact pads do not short.
In another aspect, the assembly bonding material includes a solder solution or solder paste. According to this aspect, solder solution or solder paste (not shown) is applied to either the chip contact pads or the lens contact pads in a particular assembly site. In an aspect, the solder solution/paste is applied to respective ones of either the chip contact pads or the lens contact pads using a syringe. The silicon chip 304 is then flipped over, following arrow 408, so that the surface 406 of the silicon chip 304 having the chip contact pads (e.g. the surface having the metal lines 402) faces a surface of the contact lens substrate 418 having the lens contact pads thereon. Dashed lines 402 presented on flipped chip 304 are indicative of the metal lines 402 now on the underside 306 of the chip. The chip 304 is then lowered onto the substrate 418 and the chip contact pads are aligned with the lens contact pads. Head and pressure are then applied to at least one of the chip 304 or the lens substrate 418 so that the solder solution is flowed and solidified so as to bond the chip 304 to the lens substrate 418. Arrow 410 shows an example where the chip 304 is bonded to an assembly site on the substrate 418 that comprises metal squares as contact pads. Arrow 412 shows an example where the chip 304 is bonded to an assembly site on the substrate 418 that comprises metal lines as contact pads.
In some aspects, an underfill is applied to the lens substrate/chip complex in order to hold the chip 304 onto the substrate 418. In particular, connections established between the chip 304 and the substrate 418 can be relatively weak when using a solder solution/paste as the assembly bonding material. Accordingly, an underfill material can be applied between the chip 304 and the substrate so as to flow around the respective solder pads and solidified solder material to further facilitate bonding of the chip 304 to the substrate. The underfill can include a non-conductive or substantially non-conductive material such as an epoxy or adhesive.
In an aspect, flipping 408, alignment of chip 304 with contact pads on lens substrate 418, and bonding is performed using a flip chip bonder. As used herein, the term flip chip bonder refers to a tool that performs functions and features of traditional flip chip bonding methods, including at least flipping of chip 304, alignment of chip 304 with substrate 418, and application of heat and pressure to chip 304 and substrate 418 such that the chip 304 and the substrate 418 bond via the solder solution provided there between.
In an aspect, the assembly bonding material that is applied to the lens substrate or chip is a low activation temperature material. For example, in some aspects, the assembly bonding material includes an ACF or an ACP that has a low activation temperature, such as below 200° C. In other aspects, the assembly bonding material includes a solder material that has a low melting point, such as below 200° C. In another aspect, the assembly bonding material can have an activation temperature or boiling point less than 150° C. In another aspect, the assembly bonding material can have an activation temperature or boiling point less than 100° C. In yet another aspect, the assembly bonding material can have an activation temperature or boiling point less less than 85° C. Still in yet another aspect, the assembly bonding material can have an activation temperature or boiling point less than 65° C.
Some exemplary low temperature solder solutions/pastes that can be employed as the assembly bonding material can include but are not limited to solutions or pastes having varying ratios of indium, tin, and/or bismuth. For example, indium alloy number 19 from Indium Corp. can be employed as an exemplary solder solution and has a ration of 51% In, 32.5% Bi, and 16.5 Sn with a melting temperature of about 60° C. In an aspect, an employed solder solution/paste is lead-free so as not to disrupt an eye in which a contact lens, having a chip 304 integrated therein, is worn. In some aspects, the solder solution can also be mixed with a flux or acidic solution (such as HCL and water) to prevent or reduce oxidation of the solder solution. Some exemplary fluxes can include but are not limited to TACFlux® 020B and Indalloy Flux #4-OA from Indium Corp. Additionally, a commercially available solder solution can be employed as the assembly bonding material that is formed as a paste suspended in a solder solution, such NC-SMQ®90 Solder Paste from Indium Corp.
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The contact lens substrate 1102 is used to form a contact lens form 1112. In an aspect, the contact lens substrate 1102 is molded into a shape of a contact lens form 1112. (e.g. a round and curved shape). In particular, the contact lens substrate 1102 is molded to match the curvature of an eye in which the contact lens is to be worn. In some aspects, in order to facilitate molding the contact lens substrate 1102, the contact lens substrate 1102 is cut into a shape that can be formed into the shape of a contact lens. For example, as seen in
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This application is a continuation of U.S. patent application Ser. No. 14/025,581, filed Sep. 12, 2013, which is a continuation of U.S. patent application Ser. No. 13/627,574, filed Sep. 26, 2012. The foregoing applications are hereby incorporated by reference in their entirety.
Number | Name | Date | Kind |
---|---|---|---|
3958560 | March | May 1976 | A |
4014321 | March | Mar 1977 | A |
4055378 | Feneberg et al. | Oct 1977 | A |
4122942 | Wolfson | Oct 1978 | A |
4136250 | Mueller et al. | Jan 1979 | A |
4143949 | Chen | Mar 1979 | A |
4153641 | Deichert et al. | May 1979 | A |
4214014 | Hofer et al. | Jul 1980 | A |
4309085 | Morrison | Jan 1982 | A |
4312575 | Peyman et al. | Jan 1982 | A |
4401371 | Neefe | Aug 1983 | A |
4463149 | Ellis | Jul 1984 | A |
4555372 | Kunzler et al. | Nov 1985 | A |
4604479 | Ellis | Aug 1986 | A |
4632844 | Yanagihara et al. | Dec 1986 | A |
4686267 | Ellis et al. | Aug 1987 | A |
4740533 | Su et al. | Apr 1988 | A |
4826936 | Ellis | May 1989 | A |
4996275 | Ellis et al. | Feb 1991 | A |
4997770 | Giles et al. | Mar 1991 | A |
5032658 | Baron et al. | Jul 1991 | A |
5034461 | Lai et al. | Jul 1991 | A |
5070215 | Bambury et al. | Dec 1991 | A |
5135297 | Valint et al. | Aug 1992 | A |
5177165 | Valint et al. | Jan 1993 | A |
5177168 | Baron et al. | Jan 1993 | A |
5219965 | Valint et al. | Jun 1993 | A |
5260000 | Nandu et al. | Nov 1993 | A |
5271875 | Appleton et al. | Dec 1993 | A |
5310779 | Lai | May 1994 | A |
5321108 | Kunzler et al. | Jun 1994 | A |
5326584 | Kamel et al. | Jul 1994 | A |
5336797 | McGee et al. | Aug 1994 | A |
5346976 | Ellis et al. | Sep 1994 | A |
5358995 | Lai et al. | Oct 1994 | A |
5364918 | Valint et al. | Nov 1994 | A |
5387662 | Kunzler et al. | Feb 1995 | A |
5449729 | Lai | Sep 1995 | A |
5472436 | Fremstad | Dec 1995 | A |
5512205 | Lai | Apr 1996 | A |
5585871 | Linden | Dec 1996 | A |
5610252 | Bambury et al. | Mar 1997 | A |
5616757 | Bambury et al. | Apr 1997 | A |
5682210 | Weirich | Oct 1997 | A |
5708094 | Lai et al. | Jan 1998 | A |
5710302 | Kunzler et al. | Jan 1998 | A |
5714557 | Kunzler et al. | Feb 1998 | A |
5726733 | Lai et al. | Mar 1998 | A |
5760100 | Nicholson et al. | Jun 1998 | A |
5908906 | Kunzler et al. | Jun 1999 | A |
5981669 | Valint et al. | Nov 1999 | A |
6087941 | Ferraz et al. | Jul 2000 | A |
6131580 | Ratner et al. | Oct 2000 | A |
6193369 | Valint et al. | Feb 2001 | B1 |
6200626 | Grobe et al. | Mar 2001 | B1 |
6213604 | Valint et al. | Apr 2001 | B1 |
6312393 | Abreu | Nov 2001 | B1 |
6348507 | Heiler et al. | Feb 2002 | B1 |
6366794 | Moussy et al. | Apr 2002 | B1 |
6423001 | Abreu | Jul 2002 | B1 |
6428839 | Kunzler et al. | Aug 2002 | B1 |
6431705 | Linden | Aug 2002 | B1 |
6440571 | Valint et al. | Aug 2002 | B1 |
6450642 | Jethmalani et al. | Sep 2002 | B1 |
6532298 | Cambier et al. | Mar 2003 | B1 |
6550915 | Grobe, III | Apr 2003 | B1 |
6570386 | Goldstein | May 2003 | B2 |
6579235 | Abita et al. | Jun 2003 | B1 |
6599559 | McGee et al. | Jul 2003 | B1 |
6614408 | Mann | Sep 2003 | B1 |
6630243 | Valint et al. | Oct 2003 | B2 |
6638563 | McGee et al. | Oct 2003 | B2 |
6726322 | Andino et al. | Apr 2004 | B2 |
6735328 | Helbing et al. | May 2004 | B1 |
6779888 | Marmo | Aug 2004 | B2 |
6793500 | Budell et al. | Sep 2004 | B1 |
6804560 | Nisch et al. | Oct 2004 | B2 |
6851805 | Blum et al. | Feb 2005 | B2 |
6885818 | Goldstein | Apr 2005 | B2 |
6918178 | Chao | Jul 2005 | B2 |
6939299 | Petersen et al. | Sep 2005 | B1 |
6980842 | March et al. | Dec 2005 | B2 |
7018040 | Blum et al. | Mar 2006 | B2 |
7131945 | Fink et al. | Nov 2006 | B2 |
7169106 | Fleischman et al. | Jan 2007 | B2 |
7398119 | Lambert et al. | Jul 2008 | B2 |
7423801 | Kaufman et al. | Sep 2008 | B2 |
7429465 | Muller et al. | Sep 2008 | B2 |
7441892 | Hsu | Oct 2008 | B2 |
7443016 | Tsai et al. | Oct 2008 | B2 |
7450981 | Jeon | Nov 2008 | B2 |
7639845 | Utsunomiya | Dec 2009 | B2 |
7654671 | Glynn | Feb 2010 | B2 |
7699465 | Dootjes et al. | Apr 2010 | B2 |
7728949 | Clarke et al. | Jun 2010 | B2 |
7751896 | Graf et al. | Jul 2010 | B2 |
7799243 | Mather et al. | Sep 2010 | B2 |
7809417 | Abreu | Oct 2010 | B2 |
7863722 | Chua | Jan 2011 | B2 |
7878650 | Fritsch et al. | Feb 2011 | B2 |
7885698 | Feldman | Feb 2011 | B2 |
7907931 | Hartigan et al. | Mar 2011 | B2 |
7926940 | Blum et al. | Apr 2011 | B2 |
7931832 | Pugh et al. | Apr 2011 | B2 |
7964390 | Rozakis et al. | Jun 2011 | B2 |
8080187 | Tepedino, Jr. et al. | Dec 2011 | B2 |
8096654 | Amirparviz et al. | Jan 2012 | B2 |
8118752 | Hetling et al. | Feb 2012 | B2 |
8142016 | Legerton et al. | Mar 2012 | B2 |
8224415 | Budiman | Jul 2012 | B2 |
8960899 | Etzkorn | Feb 2015 | B2 |
20020193674 | Fleischman et al. | Dec 2002 | A1 |
20030179094 | Abreu | Sep 2003 | A1 |
20040027536 | Blum et al. | Feb 2004 | A1 |
20040116794 | Fink et al. | Jun 2004 | A1 |
20050045589 | Rastogi et al. | Mar 2005 | A1 |
20050221276 | Rozakis et al. | Oct 2005 | A1 |
20070016074 | Abreu | Jan 2007 | A1 |
20070030443 | Chapoy et al. | Feb 2007 | A1 |
20070121065 | Cox et al. | May 2007 | A1 |
20070188710 | Hetling et al. | Aug 2007 | A1 |
20080108181 | Chan et al. | May 2008 | A1 |
20080208335 | Blum et al. | Aug 2008 | A1 |
20080218696 | Mir | Sep 2008 | A1 |
20080296758 | Wu | Dec 2008 | A1 |
20090033863 | Blum et al. | Feb 2009 | A1 |
20090036761 | Abreu | Feb 2009 | A1 |
20090057164 | Minick et al. | Mar 2009 | A1 |
20090076367 | Sit et al. | Mar 2009 | A1 |
20090118604 | Phan et al. | May 2009 | A1 |
20090189830 | Deering et al. | Jul 2009 | A1 |
20090196460 | Jakobs et al. | Aug 2009 | A1 |
20090197395 | Nakamura | Aug 2009 | A1 |
20100001926 | Amirparviz et al. | Jan 2010 | A1 |
20100013114 | Bowers et al. | Jan 2010 | A1 |
20100016704 | Naber et al. | Jan 2010 | A1 |
20100028559 | Yan et al. | Feb 2010 | A1 |
20100072643 | Pugh et al. | Mar 2010 | A1 |
20100103368 | Amirparviz et al. | Apr 2010 | A1 |
20100109175 | Pugh et al. | May 2010 | A1 |
20100110372 | Pugh et al. | May 2010 | A1 |
20100113901 | Zhang et al. | May 2010 | A1 |
20100133510 | Kim et al. | Jun 2010 | A1 |
20100249548 | Muller | Sep 2010 | A1 |
20100258952 | Fjelstad | Oct 2010 | A1 |
20110015512 | Pan et al. | Jan 2011 | A1 |
20110028807 | Abreu | Feb 2011 | A1 |
20110040161 | Abreu | Feb 2011 | A1 |
20110055317 | Vonog et al. | Mar 2011 | A1 |
20110084834 | Sabeta | Apr 2011 | A1 |
20110116035 | Fritsch et al. | May 2011 | A1 |
20110157541 | Peyman | Jun 2011 | A1 |
20110157544 | Pugh et al. | Jun 2011 | A1 |
20110184271 | Veciana et al. | Jul 2011 | A1 |
20110254158 | Kaylani et al. | Oct 2011 | A1 |
20110274680 | Mazed et al. | Nov 2011 | A1 |
20110286064 | Burles et al. | Nov 2011 | A1 |
20110298794 | Freedman | Dec 2011 | A1 |
20120026458 | Qiu et al. | Feb 2012 | A1 |
20120038881 | Amirparviz et al. | Feb 2012 | A1 |
20120041287 | Goodall et al. | Feb 2012 | A1 |
20120041552 | Chuck et al. | Feb 2012 | A1 |
20120069254 | Burton | Mar 2012 | A1 |
20120074598 | Kalz | Mar 2012 | A1 |
20120075168 | Osterhout et al. | Mar 2012 | A1 |
20120075574 | Pugh et al. | Mar 2012 | A1 |
20120078071 | Bohm et al. | Mar 2012 | A1 |
20120088258 | Bishop et al. | Apr 2012 | A1 |
20120092612 | Binder et al. | Apr 2012 | A1 |
20120109296 | Fan | May 2012 | A1 |
20120177576 | Hu | Jul 2012 | A1 |
20120201755 | Rozakis et al. | Aug 2012 | A1 |
20120206691 | Iwai | Aug 2012 | A1 |
20120214899 | Lee et al. | Aug 2012 | A1 |
20120235277 | Pugh et al. | Sep 2012 | A1 |
20120245444 | Otis et al. | Sep 2012 | A1 |
20120259188 | Besling | Oct 2012 | A1 |
20120320334 | Ho et al. | Dec 2012 | A1 |
Number | Date | Country |
---|---|---|
0369942 | May 1990 | EP |
0686372 | Dec 1995 | EP |
1061874 | Dec 2000 | EP |
1818008 | Aug 2007 | EP |
1947501 | Jul 2008 | EP |
1617757 | Aug 2009 | EP |
2457122 | May 2012 | EP |
2000-315855 | Nov 2000 | JP |
2003-195230 | Jul 2003 | JP |
2012-507748 | Mar 2012 | JP |
2015-515115 | May 2015 | JP |
201137433 | Nov 2011 | TW |
201235385 | Sep 2012 | TW |
9504609 | Feb 1995 | WO |
0116641 | Mar 2001 | WO |
0134312 | May 2001 | WO |
03065876 | Aug 2003 | WO |
2004060431 | Jul 2004 | WO |
2004064629 | Aug 2004 | WO |
2006015315 | Feb 2006 | WO |
2009094643 | Jul 2009 | WO |
2010051225 | May 2010 | WO |
2010105728 | Sep 2010 | WO |
2010133317 | Nov 2010 | WO |
2011011344 | Jan 2011 | WO |
2011034592 | Mar 2011 | WO |
2011035228 | Mar 2011 | WO |
2011035262 | Mar 2011 | WO |
2011083105 | Jul 2011 | WO |
2011163080 | Dec 2011 | WO |
2012035429 | Mar 2012 | WO |
2012037455 | Mar 2012 | WO |
2012051167 | Apr 2012 | WO |
2012051223 | Apr 2012 | WO |
2012052765 | Apr 2012 | WO |
Entry |
---|
Badugu et al., “A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring,” Journal of Fluorescence, Sep. 2003, pp. 371-374, vol. 13, No. 5. |
Carlson et al., “A 20 mV Input Boost Converter With Efficient Digital Control for Thermoelectric Energy Harvesting,” IEEE Journal of Solid-State Circuits, Apr. 2010, pp. 741-750, vol. 45, No. 4. |
Chu et al., “Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents,” Biomed Microdevices, 2011, pp. 603-611, vol. 13. |
Chu et al., “Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment,” Talanta, 2011, pp. 960-965, vol. 83. |
Ho et al., “Contact Lens With Integrated Inorganic Semiconductor Devices,” MEMS 2008. IEEE 21st International Conference on. IEEE, 2008., pp. 403-406. |
Lähdesmäki et al., “Possibilities for Continuous Glucose Monitoring by a Functional Contact Lens,” IEEE Instrumentation & Measurement Magazine, Jun. 2010, pp. 14-17. |
Lingley et al., “A contact lens with integrated micro solar cells,” Microsyst Technol, 2012, pp. 453-458, vol. 18. |
Parviz, Babak A., “For Your Eyes Only,” IEEE Spectrum, Sep. 2009, pp. 36-41. |
Saeedi, E. et al., “Self-assembled crystalline semiconductor optoelectronics on glass and plastic,” J. Micromech. Microeng., 2008, pp. 1-7, vol. 18. |
Saeedi et al., “Self-Assembled Inorganic Micro-Display on Plastic,” Micro Electro Mechanical Systems, 2007. MEMS. IEEE 20th International Conference on. IEEE, 2007., pp. 755-758. |
Sensimed Triggerfish, Sensimed Brochure, 2010, 10 pages. |
Shih, Yi-Chun et al., “An Inductorless DC-DC Converter for Energy Harvesting With a 1.2-μW Bandgap-Referenced Output Controller,” IEEE Transactions on Circuits and Systems—II: Express Briefs, Dec. 2011, pp. 832-836, vol. 58, No. 12. |
Shum et al., “Functional modular contact lens,” Proc. of SPIE, 2009, pp. 73970K-1 to 73970K-8, vol. 7397. |
Stauth et al., “Self-assembled single-crystal silicon circuits on plastic,” PNAS, Sep. 19, 2006, pp. 13922-13927, vol. 103, No. 38. |
Yao, H. et al., “A contact lens with integrated telecommunication circuit and sensors for wireless and continuous tear glucose monitoring,” J. Micromech. Microeng., 2012, pp. 1-10, vol. 22. |
Yao, H. et al., “A Dual Microscal Glucose Sensor on a Contact Lens, Tested in Conditions Mimicking the Eye,” Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on. IEEE, 2011, pp. 25-28. |
Yao et al., “A contact lens with embedded sensor for monitoring tear glucose level,” Biosensors and Bioelectronics, 2011, pp. 3290-3296, vol. 26. |
Yao, H. et al., “A Soft Hydrogel Contact Lens with an Encapsulated Sensor for Tear Glucose Monitoring,” Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on. IEEE, 2012, pp. 769-772. |
Yeager et al., “A 9 μA, Addressable Gen2 Sensor Tag for Biosignal Acquistion,” IEEE Journal of Solid-State Circuits, Oct. 2010, pp. 2198-2209, vol. 45, No. 10. |
Zhang et al., “Design for Ultra-Low Power Biopotential Amplifiers for Biosignal Acquistion Applications,” IEEE Transactions on Biomedical Circuits and Systems, 2012, pp. 344-355, vol. 6, No. 4. |
Baxter, “Capacitive Sensors,” 2000, 17 pages. |
“Polyvinylidene fluoride,” Wikipedia, http://en.wikipedia.org/wiki/Polyvinylidene—fluoride, Last accessed Mar. 30, 2012, 4 pages. |
Unpublished U.S. Appl. No. 13/240,994, Titled “See-Through Display With Infrared Eye-Tracker,” filed Sep. 22, 2011, 38 pages. |
Unpublished U.S. Appl. No. 13/209,706, Titled “Optical Display System and Method with Gaze Tracking,” filed Aug. 15, 2011, 30 pages. |
Adler, “What types of statistical analysis do scientists use most often?” O'Reilly Community, Jan. 15, 2010, 2 pages, http://broadcast.oreilly.com/2010/01/what-types-of-statistical-anal.html, Last accessed Sep. 4, 2012. |
Bull, “Different Types of Statistical Analysis,” Article Click, Feb. 4, 2008, 4 pages, http://www.articleclick.com/Article/Different-Types-Of-Statistical-Analysis/968252, Last accessed Sep. 4, 2012. |
“Understanding pH measurement,” Sensorland, 8 pages, http://www.sensorland.com/HowPage037.html, Last accessed Sep. 6, 2012. |
“Regression analysis,” Wikipedia, 11 pages, http://en.wikipedia.org/wiki/Regression—analysis, Last accessed Sep. 6, 2012. |
“Statistics,” Wikipedia, 10 pages, http://en.wikipedia.org/wiki/Statistics, Last accessed Sep. 6, 2012. |
“Nonlinear regression,” Wikipedia, 4 pages, http://en.wikipedia.org/wiki/Nonlinear—regression, Last accessed Sep. 10, 2012. |
“Linear regression,” Wikipedia, 15 pages, http://en.wikipedia.org/wiki/Linear—regression, Last accessed Sep. 10, 2012. |
“Integrated circuit,” Wikipedia, 9 pages, http://en.wikipedia.org/wiki/Integrated—circuit, Last accessed Sep. 10, 2012. |
“Photolithography,” Wikipedia, 8 pages, http://en.wikipedia.org/wiki/Photolithography, Last accessed Sep. 10, 2012. |
“Alcohol Detection Technologies: Present and Future,” American Beverage Institute, 9 pages. |
Harding, et al., “Alcohol Toxicology for Prosecutors: Targeting Hardcore Impaired Drivers,” American Prosecutors Research Institute, Jul. 2003, 40 pages. |
Quick, “Color-changing electrochromic lens technology has fashion and military applications,” Gizmag, Jul. 12, 2011, http://www.gizmag.com/electrochromic-lens-technology/19191/, Last accessed Apr. 12, 2012, 4 pages. |
Chu, “Contact Lenses that Respond to Light,” Technology Review, Nov. 10, 2009, http://www.technologyreview.com/printer—friendly—article—aspx?id=23922, Last accessed Apr. 12, 2012, 2 pages. |
International Searching Authority, International Search Report and Written Opinion for PCT/US2013/059256 mailed Dec. 10, 2013, 10 pages. |
Kim et al., “Oral Alcohol Administration Disturbs Tear Film and Ocular Surface,” American Academy of Ophthalmology, 2012, 7 pages. |
Bionic contact lens ‘to project emails before eyes,’ http://www.kurzweilai.netforums/topic/bionic-contact-lens-to-project-emails-before-eyes, Last accessed Mar. 14, 2012, 2 pages. |
Brahim, et al., “Polypyrrole-hydrogel composites for the construction of clinically important biosensors,” 2002, Biosensors & Bioelectronics, pp. 53-59, vol. 17. |
Chen, et al., “Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors,” Journal of Microelectromechanical Systems, Dec. 2008, pp. 1342-1351, vol. 17, No. 6. |
Chu, et al., “Soft Contact-lens Sensor for Monitoring Tear Sugar as Novel Wearable Device of Body Sensor Network,” http://www.ksi edu/seke/dms11/DMS/2—Kohji—Mitsubayashi.pdf, Last accessed Jul. 27, 2012, 4 pages. |
“Contact Lenses: Look Into My Eyes,” The Economist, Jun. 2, 2011 , http://www.economist.com/node/18750624/print, Last accessed Mar. 13, 2012, 8 pages. |
Haders, “New Controlled Release Technologies Broaden Opportunities for Ophthalmic Therapies,” Drug Delivery Technology, Jul./Aug. 2009, pp. 48-53, vol. 8, No. 7. |
Holloway, “Microsoft developing electronic contact lens to monitor blood sugar,” Gizmag, Jan. 5, 2012, http://www.gizmag.com/microsoft-electronic-diabetic-contact-lens/20987/, Last accessed Mar. 13, 2012. 5 pages. |
Huang, et al., “Wrinkling of Ultrathin Polymer Films,” Mater. Res. Soc. Symp. Proc., 2006, 6 pages, vol. 924, Materials Research Society. |
Hurst, David “How contact lenses could help save your life,” Mail Online, Apr. 19, 2010, http://www.dailymail.co.uk/health/ article-1267345/How-contact-lenses-help-save-life.html, Last accessed Jul. 27, 2012. |
Liao et al., “A 3-μW CMOS Glucose Sensor for Wireless Contact-Lens Tear Glucose Monitoring ,” IEEE Journal of Solid-State Circuits, Jan. 2012, pp. 335-344, vol. 47, No. 1. |
Liao, et al., “A 3μW Wirelessly Powered CMOS Glucose Sensor for an Active Contact Lens,” 2011 IEEE International Solid-State Circuits Conference, Session 2, Feb. 21, 2011, 3 pages. |
Lingley et al., “A Single-Pixel Wireless Contact Lens Display,” Journal of Micromechanics and Microengineering, 2011, pp. 1-8. |
Lingley et al., “Multipurpose integrated active contact lenses,” SPIE, 2009, 2 pages. |
Liu, et al., “Miniature Amperometric Self-Powered Continuous Glucose Sensor with Linear Response,” Analytical Chemistry, 2012, 7 pages. |
Loncar, et al., “Design and Fabrication of Silicon Photonic Crystal Optical Waveguides,” Journal of Lightwave Technology, Oct. 2000, pp. 1402-1411, vol. 18, No. 10. |
Murdan, “Electro-responsive drug delivery from hydrogels,” Journal of Controlled Release, 2003, pp. 1-17, vol. 92. |
Pandey, et al., “A Fully Integrated RF-Powered Contact Lens With a Single Element Display,” IEEE Transactions on Biomedical Circuits and Systems, Dec. 2010, pp. 454-461, vol. 4, No. 6. |
Parviz, Babak A., “Augmented Reality in a Contact Lens,” IEEE Spectrum, Sep. 2009, http://spectrum.ieee.org/biomedical/bionics/augmented-reality-in-a-contact-lens/0, Last accessed Mar. 14, 2012, 6 pages. |
Selner, et al., “Novel Contact Lens Electrode Array for Multi-electrode Electroretinography (meERG),” IEEE, 2011, 2 pages. |
Singh et al., “Novel Approaches in Formulation and Drug Delivery using Contact Lenses,” Journal of Basic and Clinical Pharmacy, May 2011, pp. 87-101, vol. 2, Issue 2. |
Thomas et al., “Functional Contact Lenses for Remote Health Monitoring in Developing Countries,” IEEE Global Humanitarian Technology Conference, 2011, pp. 212-217, IEEE Computer Society. |
Tweedie et al., “Contact creep compliance of viscoelastic materials via nanoindentation,” J. Mater. Res., Jun. 2006, pp. 1576-1589, vol. 21, No. 2, Materials Research Society. |
Wall, Kristen, “Active contact lens that lets you see like the Terminator patented,” Feb. 10, 2012, http://vvww.patexia.com/feed/active-contact-lens-that-lets-you-see-like-the-terminator-patented-2407, Last accessed Mar. 28, 2012, 5 pages. |
Zarbin, et al., “Nanotechnology in ophthalmology,” Can J Ophthalmol, 2010, pp. 457-476, vol. 45, No. 5. |
Fujiwara et al., “Deterioration Mechanism of Flip Chip Attachment Using an Anisotropic Conductive Film and Design Technology for High Reliability,” 2002 Electronic Components and Technology Conference, May 28, 2002, pp. 1124-1129. |
European Patent Office, Supplementary European Search Report mailed on Mar. 23, 2016, issued in connection with European Application No. 13 84 2053, 12 pages. |
Japanese Patent Office, Office Action mailed on Apr. 13, 2016, issued in connection with Japanese Application No. JP 2015-534523, 6 pages. |
Number | Date | Country | |
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20150212340 A1 | Jul 2015 | US |
Number | Date | Country | |
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Parent | 14025581 | Sep 2013 | US |
Child | 14678198 | US | |
Parent | 13627574 | Sep 2012 | US |
Child | 14025581 | US |